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Cyclodepsipeptides: Isolation, Bioactivities, Biosynthesis and Total Synthesis Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2024-02-22 Ning Chen, Xue Tian, Bing Liu, Ting Zhu, Jintong Zhao, Ting Li
: Cyclodepsipeptides, mainly derived from marine organisms and soil microorganisms, are amphiphilic molecules consisting of short oligopeptides with fatty acid tails attached to form a macrocyclic structure. Studies on the activity of cyclodepsipeptides have shown that they have cytotoxicity, antibacterial and anthelmintic effects, and are widely used in biological control, drug development, environmental
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Advances in Chemical Epigenetic Modification Methods in the Study of Fungal Secondary Metabolites Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2024-02-02 Bing Liu, Yuxin Wang, Ning Chen, Chenxue Li, Jintong Zhao, Ting Li
: The secondary metabolites produced by fungi are an important resource for new drug development, and the biosynthesis of fungal secondary metabolites is closely related to the epigenetic status of the chromosomes in which their gene clusters are located. However, the induction of fungal silencing of gene expression is one of the challenges faced at this stage. Chemical epigenetic modification is a
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An Overview of Diverse Biological Activities of Cinnoline Scaffold Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2024-02-02 Mohammad Asif, Mamdouh Allahyani, Abdulelah Aljuaid, Mazen M. Almehmadi, Ahad Alsaiari, Abdulaziz Alsharif
: The cinnoline nucleus is a bicyclic ring and is an isosteric precursor to quinolone or isoquinoline. Cinnoline analogs are aromatic heterocyclic compounds having diverse therapeutic activities, such as antimicrobial, analgesic, anti-inflammatory, anti-tuberculosis, antimalarial, anticonvulsant, antioxidant, anticancer, antihypertensive, anti-anxiety, and other activities. This heterocyclic nucleus
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Neuropharmacological Potential of Different Piperazine Analogs: A Recent Prospective Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2024-02-02 Mamdouh Allahyani, Mazen Almehmadi, Ahad Amer Alsaiari, Mohammad Asif, Sachin Kumar
: Heterocyclic moiety is a key part of some enzymes and vitamins and plays a vital role in various biochemical and enzymatic processes. Piperazine ring is a heterocyclic moiety present in various well-known drugs and is effective against different types of diseases by acting on a variety of receptors. Various piperazine analogs possess diverse biological activities, especially in central nervous system
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Last Decades’ Overview on Tandem Catalysis: Intrigue in Organo-metallic Chemistry Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2024-02-01 Jyoti Kuchhadiya, khushal kapadiya
: Catalytic transformations have been observed in every reaction to provide a specific product and to formulate regio and stereo-selective adducts in well-defined pathways. Among various catalytic processes used in current chemistry, tandem catalysis has been proven to be an effective technology by applying the technology for better and time-saving ways of production. It has shown its usability in
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Electrosynthesis of Sugar Derivatives Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2024-02-01 Cintia Santiago, Natividad Bejarano Rengel, Pablo Fernández, Agustin Ponzinibbio
: The last decades have witnessed significant advances in the synthesis of bioactive carbohydrates. As in all fields of organic synthesis, the search for more environmentally friendly alternative synthetic methods is a current and expanding concern. Consequently, electrochemical organic synthesis has emerged as an efficient and sustainable methodology. Herein, we present recent developments in the
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A Systematic Review of Electrochemical Sensing Devices Based on Metal-organic Frameworks for the Identification of Tumor Biomarkers Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2024-02-01 Aiany Maria Queiroz Felix, Karen Loraine Macena Santos, Severino Alves Júnior, Maria Danielly Lima Oliveira, César Augusto Souza de Andrade
Background:: Electrochemical sensors have attracted enormous interest in recent decades due to their relatively simple synthesis process, the possibility of modifications in their composition, and their wide application in detecting analytes. Method:: To achieve excellent performance, materials used in its construction must facilitate the transfer of electrons and provide a large surface area and excellent
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An Attractive and Comprehensive Review on C-O Bond Formation: Nanomagnetic Recoverable Catalysts to Access Diaryl Ethers via C-O Cross-coupling Reactions Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2024-01-25 Marim Alwan, Shaymaa Abed Hussein, Usama S. Altimari, Mustafa Humam Sami, Ashour H. Dawood, Benien M. Ridha, Ali H. Alsalamy, Mosstafa Kazemi
: The simple separation of magnetic nanocatalysts from the reaction mixture using only an external magnet caused a huge revolution in catalysis, particularly in organic synthesis. Diaryl ethers (compounds containing (Ar-O-Ar linkages) are one of the most important and prominent compounds and are widely found in natural products and pharmaceutical and biological molecules. The C-O cross-coupling or
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Biological Activities of Aurones: A Brief Summary Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2024-01-11 Qiang Zhu, Xing Zheng, Yan Tan, Zhongqin Luo, Xu Yao, Hongfei Chen
: Aurones are structural isomers of flavones and flavonols with the basic C6–C3–C6 skeleton arranged as (Z)-2-benzylidenebenzofuran-3(2H)-one, which contain an exocyclic carbon-carbon double bond bridging the benzofuranone and phenyl rings. In aurone, a chalcone-like group is closed into a 5-membered ring instead of the 6-membered ring more typical of flavonoids, which forms the core for a family of
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Synthesis, Reactions and Biological Activity of Pyrimido [5, 4-c] Quinolines based on (Thio)Barbituric Acid and their Analogous (Part IV) Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2024-01-11 Ameen Abu-Hashem, Taha Ameen, Emad El-Telbani, Hoda A.R. Hussein, Moustafa Gouda
: Pyrimido [5, 4-c] quinolone derivatives are significant synthetic targets that show numerous interesting biological activities. The pyrimido [4, 5-b] quinoline is the most famous source of these derivatives, which has been used in medicine to antitumor and target different diseases. Since the segregation of quinoline derivatives, many synthetic methodologies were advanced for their synthesis. Despite
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A Review on the Role of Sea Salt in Food and its Applications for Human Health Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2024-01-11 Thi-Kien Dao, Trong-The Nguyen, Ngoc-Thanh Vu
: Sea salt is a widely used ingredient in culinary practices around the world. Beyond its flavor-enhancing properties, sea salt has been recognized for its potential health benefits. This review aimed to explore the role of sea salt in food and its applications for promoting human health. We have discussed the composition and production of sea salt, its culinary uses, and its impact on various aspects
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Functionalization of semi-conductive interfaces with cucurbit[n]urils Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2024-01-05 Andisiwe Ngwekazi, Christopher Arendse, Priscilla Baker
: Cucurbiturils are a class of macrocyclic compounds with highly polar carbonyl portals and a hydrophobic cavity. They are usually utilized as efficient host molecules in supramolecular chemistry applications due to their high binding affinity for positively charged or cationic compounds. This review investigates the application of CB[n] immobilization at semi-conductive interfaces to produce electrochemical
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Recent Advances in the Construction of Coumarin or Quinolin-2-ones Compounds via Radical Cascade Reactions Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2024-01-05 Shuo Zhang, Wei Tang, Kai Zhou, Xiao-Xiao Huan, Zhi-Wei Chen
: Free radical reactions occupy an important position in synthetic organic chemistry as well as medicinal chemistry, significantly complementing and extending the synthesis of coumarin or quinolin-2-one compounds. Moreover, the use of constructing coumarin or quinolin-2-one compounds functionalized at the C3 position has certain advantages over traditional noble metalcatalyzed or high-temperature cyclization
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Asciminib - ABL Kinase Inhibitor in the Treatment of Philadelphia Chromosome Positive Chronic Myeloid Leukemia: Chemistry and Pharmacology Perspectives Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-10-19 Umang Shah, Prachi Patel, Alkesh Patel, Dhruvi Gajjar, Mehul Patel, Nilay Solanki, Swayamprakash Patel, Ashish Patel, Rajesh Maheshwari
: Asciminib, also known as ACP-196, is the FDA-approved low-molecular ABL kinase inhibitor. The ABL kinase is a non-receptor tyrosine kinase that helps in cell growth and survival and is a key player in the development of chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL). The BCR-ABL fusion protein, which is formed by chromosomal translocation
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Introduction to a New Technique in Organic Synthesis: Recent Advances in Aqueous Reactions of Sparingly Soluble High-Melting Point Substrates Promoted by Granular Polytetrafluoroethylene Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-10-11 Linlin Xing, Yong Zhang, Taixuan Jia, Chunbao Li
: Water, a kind of abundant natural resource, is considered to be a green and desirable solvent for reasons of its low cost, high safety and environmental friendliness. This review article aims to briefly introduce the methodologies that have utilized water as reaction media under the aid of granular polytetrafluoroethylene (PTFE) to mediate reactions of a series of water-insoluble and high melting
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Xanthates and Dithiocarbamates: Synthesis, Characterization and Application in Flotation Processes Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-10-11 Nadezhda V. Vchislo, Ekaterina A. Verochkina, Igor B. Rozentsveig, Alexander E. Burdonov
: It is known that flotation is the main method of extracting non-ferrous metals. The need of modern society for precious metals is constantly growing, and deposits of easily reversible ores are being depleted. Therefore, the improvement of the reagent regime and the search for new flotation reagents is an urgent task. We analyzed the literature data on the synthesis and use of common collectors such
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Photochemistry of Riboflavin: The Primary Transients Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-09-19 Igor V. Khudyakov
: Primary photoreactions of riboflavin (Rf) are considered. The goal was to present data on the transients formed under photoexcitation of Rf: excited singlet and triplet states, triplet reactions with the formation of Rf neutral free radicals, and a radical anion. The absorption spectra of transients are presented, as are the rate constants of their decay. Special attention is devoted to Rf in water
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Epigrammatic Review on Heterocyclic Moiety Pyrazole: Applications and Synthesis Routes Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-09-19 Sapna Jain
Heterocyclic compounds are amongst the most promising and versatile classes of biologically important molecules. One of the heterocycle molecules is pyrazole with a five-membered heterocyclic ring with two neighboring nitrogen. Pyrazole and its derivatives have shown a broad range of biological applications like antibacterial, antifungal, antiviral, anti-inflammatory, anti-cancerous, and herbicidal
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Recent Advances in Total Synthesis of Tetrahydroisoquinoline Alkaloids Quinocarcin and Lemonomycin Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-09-19 Ju Guo, Yang Yang, Lanhua Shen, Jingyi Li, Fuan Li, Sifan Wang
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Synthetic Approaches and Reactions of 2-(Arylidene)benzo[b]thiophen-3(2H)one-1,1-dioxides Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-09-11 RAJ KUMAR, Subrata Barick, Manvendra Kumar
: 2-(Arylidene)benzo[b]thiophen-3(2H)one 1,1-dioxides are oxidized form of thioaurones. Various methods have been reported for their synthesis, e.g., a) condensation of benzo[b]thiophen-3(2H)one 1,1-dioxides with aryl aldehydes under acidic or basic conditions, b) oxidation of thioaurones with hydrogen peroxide or sodium perborate tetrahydrate, c) from the catalytic reaction of iodonium ylides with
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Natural Existence and Bioactivity of Flavonoids: Synthetic Strategies and Mechanistic Pathways Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-09-08 Shivangi Sharma, Pankaj Kumar Mishra, Shivendra Singh
: A class of chemicals known as flavonoids is widely distributed in various portions of plants, cereals, and vegetables. They have varied phenolic structures and these flavonoid molecules are known for the well-being improvement in living things. Today, a wide range of pharmaceutical, medicinal, & cosmetic materials possessed these key ingredients, known as flavonoids. Flavonoids can modulate the bioactivity
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Recent Advances in Transition Metal Catalyzed Synthesis of C3-Substitution-free 2-Oxindole Derivatives Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-09-06 Partha Pratim Das, Debapratim Das
2-Oxindole unit is one of the most important scaffolds found in several alkaloids, natural products, antitumor agents, pharmaceutically important compounds, etc. Molecules containing the 2- oxindole moiety were first isolated from the cat claw plant, widely distributed in the Amazon jungle. It has now been demonstrated that these molecules are present in a wide range of chemicals derived from plant
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A Review on Synthesis, Characterization, and Pharmacological Properties of Some Sydnone Derivatives Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-09-01 Takallum Khan, Ritu Yadav, Amul Kumar Kesharwani, Karuna Chourasia
: The mesoionic compounds have great importance due to their dipolar nature. They are versatile synthons in synthetic chemistry and possess various chemotherapeutic activities. The most important moiety found in mesoionic compounds is the sydnone ring system. Sydnone derivatives have stimulated much interest among synthetic researchers as a result of their unique dipolar, mesoionic character. This
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Anti-inflammatory alkaloids targeting IL-1 against Respiratory Viral infections: A Special insight into drug development against SARS-CoV 2 Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-08-22 Salma Batool, Laiba Asim, Jin Zhang, Fawad Raffaq Qureshi, Rahman Shah Zaib Saleem
: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest viruses among respiratory viruses which resulted in COVID-19 pandemic. The virus gets transmitted by the nasal route and moves down to the trachea, bronchi, and then to the lungs. Once replicated inside the alveolar cells, the SARS-CoV-2 makes the membrane of the alveolar sac porous, which causes the leaking of plasma
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Diphenyl Ethers: Isolation, Bioactivities and Biosynthesis Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-08-09 Bing Liu, Yuxin Wang, Ning Chen, Chenxue Li, Jintong Zhao, Ting Li
Diphenyl ethers (DPEs) are mainly produced by microorganisms and plants. The chemical structure of DPEs is relatively simple, and all of these compounds have the structure of biphenyl ethers in their chemical structure, the difference being the difference in the substituents on the benzene ring. Several recent studies have shown antibacterial, antioxidant, antitumor, antitumor, antihemolytic, neuroprotective
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Metal-based Ionic Liquids and Solid-loaded Catalysts in Fuel Oil Desulfurization: A Review Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-08-03 Anqi Niu, Hang Xu, Qinlin Yuan, Fengmin Wu, Xuefeng Wei
Metal-based ionic liquids (MILs) have the advantages of designability, efficiency, stability, and regenerative cycle and can efficiently convert thiophene and its derivatives, which are important for the production of
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Hydrogen bonding in triflamide and its derivatives Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-07-25 Irina V. Sterkhova, Bagrat A. Shainyan
: This review focuses on studying hydrogen bonds in triflamide derivatives, the supramolecular structures formed in a crystal, solution, and gas phase, and the relationship between structural, spectral data and quantum chemical calculation data.
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Recent Progress in Synthetic Chemistry and Biological Activities of Pyrimido[ 4,5-b] Quinoline Derivatives (Part III) Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-07-20 Moustafa A. Gouda, Ameen A. Abu-Hashem, Tahah A. Ameen, Mohammed A. Salem, Ateyatallah Aljuhani
Amongst heterocyclic compounds, quinoline and pyrimidine are advantaged scaffolds that appear as significant assembly motifs for the development of new drug entities. Moreover, quinolinepyrimidine- inspired hybrids have a number of biological characteristics that are known. In addition, many pyrimido[4,5-b]quinoline ring systems (PyQs4,5-b), specifically concerning medicinal chemistry, have been reported
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Recent Advances in Synthesis and Applications of Organic Ionic Saltsbased Sensor Arrays Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-07-20 Pawanpreet Kaur, Anupama Parmar, Harish Kumar Chopra
Sensor arrays contain a group of sensors, improve observations with new dimensions, provide better estimations, and additional parameters in comparison to the individual selective sensor. The array-based sensing technique provides good performance to respond to various gaseous or liquid analytes. Room temperature ionic liquids (RTILs) (melting point
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Alkaloids and Polyketides from Mangrove Associated Fungi viz. Aspergillus sp. and Penicillium sp. and Fusarium sp.: A review Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-07-19 Abhay B. Fulke, Avinash Awashank, Supriya Tilvi
: In-depth research is being carried out on mangrove communities, which are regarded as significant habitats for biodiversity, in order to find novel secondary metabolites with useful pharmaceutical and medicinal uses. According to a growing number of articles that point to the enormous potential of this ecological niche, mangrove-associated fungi are acknowledged as a rich source of bioactive chemicals
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Dichlorophosphoryl Isocyanate: Synthesis, Chemical Reactions, and Biological Activity of its Derivatives Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-07-17 Faten Medini, Lotfi Mohamed Aroua, Nejib Ben Hussein Mekni
Dichlorophosphoryl isocyanate (DCPI) is the most basic and easy phosphoric isocyanate substrate that introduces organic moieties. Synthesized since 1954, the DCPI has a high reactivity toward primary and secondary alkyl, alcohols, phenols, thiols, and amines via the nucleophilic addition reaction on the carbon atom of the isocyanate group. In addition to their synthesis, the resulting products undergo
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Diverse Heterocyclic Molecules Targeting Oxidative Stress as Therapeutic Effects Against Various Neurological Diseases Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-07-13 Mohammad Asif, Saad Alghamdi, Ahmed Kabrah, Elshiekh Babiker Khidir, Issa Saad Al-Moraya
: Heterocyclic compounds are the most common and diverse group of organic substances. Heterocyclic compounds are rapidly increasing in number as a result of intensive synthetic research as well as their value in other synthetic procedures. More than 90% of medications contain heterocyclic rings, and a wide range of medicinal chemistry applications make use of these substances. There are always unique
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Chemistry and Biological Activity of Thieno[3,4-b]quinoline, Thieno[3,4-c] quinolone, Thieno[3,2-g]quinoline and Thieno[2,3-g]quinoline Derivatives: A Review (Part IX) Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-07-07 Ameen A. Abu-Hashem, Ahmed A.M. Abdelgawad, Moustafa A. Gouda
Over the previous decades, thieno-quinoline derivatives have acquired great interest due to their synthetic and biological applications. These reports have been disclosed on Thienoquinoline synthesis such as thieno[3,4-b]quinoline; thieno[3,4-c]quinolone; thieno [3,2-g]quinoline; thieno[2,3-g] quinoline; spiro-thieno[2,3-g]quinoline; benzo[b]thiophen-iso- quinoline derivatives, and therefore in the
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Biginelli Reaction: A Multi-Component Type of Reaction and Synthetic Advancement in the Synthesis of Bioactive Dihydropyrimidinone Derivatives Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-07-07 Ramesh Ambatwar, Vaibhav Gupta, Sumit Kumar, Gopal L. Khatik
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1-Cyanoacetylthiosemicarbazides: Recent Advances in their Synthesis, Reactivity in Heterocyclization, and Bio-Applications Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-07-07 Samir Bondock, Nada Alabbad, Aisha Hossana, Moaz Abdou
The synthesis of 1-cyanoacetylthiosemicarbazides is at the apex attention of researchers due to their multifaced reactivity as versatile precursors in the synthesis of mono-, bi-, and fused_heterocyclic compounds as well as metal complexes. Despite this, no comprehensive survey was, so far, dedicated to the synthesis, chemical transformation, and bioactivities of this relevant family of synthetic organic
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Research Progress on Activity and Biosynthesis of Diketopiperazines Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-07-03 Bing Liu, Ruiyang Lu, Ning Chen, Hongliang Yuan, Jintong Zhao, Yuechen Zhao
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Recent Progress for the Synthesis of Pyrrole Derivatives – An Update Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-06-26 Dharti Patel, Drashti Shah, Krishi Patel, Ayush Patel, Tushar Bambharoliya, Anjali Mahavar, Ashish Patel
Pyrrole is a versatile heterocyclic moiety exhibiting a wide range of pharmacological actions with high therapeutic value. The importance of pyrrole in the pharmaceutical field lies in its versatility, selectivity, and biocompatibility, and these properties make it a valuable tool for drug design and development. The pyrrole moiety is a fundamental building block for many biologically active molecules
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Chemistry of Thieno [2,3-h]-/[3,2-h] Quinoline and Thieno [2,3-f]-/[3,2-f] Quinoline Derivatives Part (x), Reactivities, and Biological Activities Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-06-23 Moustafa A. Gouda, Nahlah A. Al-Hadhrami, Amin A. Abu-Hashem, Ahmed A.M. Abdelgawad, Mohamed A. Salem
Several thieno [2,3-h] /[3,2-h] quinolines and thieno [2,3-f] /[3,2-f] quinolines (TQs) are discussed in this review from a few perspectives, including various preparation and processing methods employing cutting-edge machinery. The preparation of (TQs), from 4-(5)aminobenzothiophene, 2(3)chloromethylthiophene, 2(3)thienylboric acid, and other chemical reagents is illustrated via a number of chemical
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New Strategies in the Chemical Control of Fusarium oxysporum Using Synthetic Bioisosteres of Secondary Metabolites: A Review of the Synthetic Methods for Novel Compounds with Potential Antifungal Activity Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-06-22 Paola Borrego-Muñoz, Ericsson Coy-Barrera, Diego Quiroga
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Developments in Synthesis Strategies of Spiro-Barbiturate Compounds: A Classified Study Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-06-22 Devanshi Magoo, Anju Srivastava, Shruti Gupta, Reena Jain, Soma Mondal Ghorai, Yashna Dawer, Sumedha Sengupta, Soni Rani
Spiro compounds being multi-cyclic systems linked by a single atom, have distinct three dimensionalities, and prominently hold a position of interest in the fields of synthetic and medicinal chemistry, pharmacology, material sciences and physics. Spirobarbiturate compounds which incorporate barbituric ring derivatives into spirocyclic structures have emerged as attractive synthetic targets for drug
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Quinoline and Analogs: Insight into the Synthesis, Biological Activity, Structure-Activity Relationship, and Interaction with Targets Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-06-21 Upendra Kumar, Rajnish Kumar, Avijit Mazumder, Salahuddin, Himanshu Singh, Ranjeet Yadav, Greesh Kumar
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Ionic Liquids as a Non-conventional Catalyst for the Synthesis of N-heterocycles Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-06-21 Pradeep Pratap Singh, Saraswati Kanodia, Ambika
Ionic liquids (ILs) have emerged as one of the potential alternates of organic solvents in chemistry. Nitrogen-containing heterocyclic compounds are the important structural motifs of some bioactive compounds. A variety of ILs, such as first-generation, second-generation, and thirdgeneration ILs have been used in the synthesis of various types of nitrogen-containing heterocyclic compounds, such as
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Advances in Chemistry of 2-(Piperazin-1-yl) Quinoline (Part IV) Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-06-19 Ghada G. El-Bana, Moustafa A. Gouda
This review described the preparation of 2-(piperazin-1-yl) quinoline derivatives from 2- haloquinolines and anilides, which underwent alkylation, arylation, acylation, and reductive amination to form the 2-piprazinoquinolines. 2-(Piperazin-1-yl) quinoline used as building blocks for the synthesis of polyfunctionalized heterocyclic compounds with pharmacological interest.
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Zinc Acetate in Organic Synthesis and Catalysis: A Review Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-06-12 Mohammed Mujahid Alam, Ravi Varala, Vittal Seema
Among the many zinc salts that can be found, zinc acetate is one of the readily available, affordable, low-hazardous Lewis acids. It can be referred to as a multifunctional catalyst due to its unique physical and chemical properties, which show that they are effective in enabling a variety of synthetic transformations in both organic synthesis and catalysis. This review included noteworthy innovations
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Azo Based Chromogenic Sensor: An Approach for Naked Eye Detection of Biologically Relevant Anions and Metal Cations Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-06-12 Kanchan Ramsingh Damade, Dhananjay Hiraman More
It was previously reported that azo compounds are vigorous and chemically stable compounds and well-known chromophores. Having different chromophores, the azo dyes act as probing units for capturing the charged particles either by electron transfer or deprotonation mechanisms. The probing efficiency usually exhibits in the magnitude of variations in UV absorbance, NMR peaks and visually observed color
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A Decennial Update on the Applications of Trifluroacetic Acid Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-06-08 Mohammed Mujahid Alam, Ravi Varala, Vittal Seema
Since its discovery at the beginning of the 20th century, trifluoroacetic acid, commonly known as TFA, has seen extensive application in organic synthesis both as a solvent and as a catalyst/ reagent. TFA can be used to facilitate a wide variety of chemical transformations, including rearrangements, functional group deprotections, condensations, hydroarylations and trifluoroalkylations, among others
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Chemistry of Thieno[2,3-c]quinoline Derivatives Part (VII), Reactivities, and Biological Activities Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-06-05 Moustafa A. Gouda, Rayan M. Alansari, Ameen A. Abu-Hashem, Abdel-Rahman B.A. El-Gazzar, Ahmed A.M. Abdelgawad, Mohammed A. Salem
In this review, numerous thieno[2,3-c]quinoline derivatives (TQs2, 3-c) are presented from a variety of angles, including various preparation and processing techniques, using cutting-edge equipment. Numerous chemical processes in this review demonstrate how (TQs2, 3-c) were made from arylamines, ketones, aldehydes, carboxylic acids, and other chemical reagents. The amidation, tandem C-C and C-N bond
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Functional Modification of Meta-aramid: A Review Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-05-12 Zheng Zhang, Xiaoyan Wang, Changhai Xu, Yang Jiang, Jinmei Du
Meta-aramid is a high-performance polymer based on amide aromatic rings, which has excellent properties because of its amide bonds and rigid aromaticity. Meta-aramid has been widely used in the fields of transportation, energy, communication, high-performance protective clothing, military, and aerospace due to its extraordinary thermal stability, mechanical properties, and chemical structural stability
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Gold-catalyzed Reactions of Substituted 1,5-diynes: Recent Advances and their Chemistry Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-05-08 Perla Bharath Kumar, Kongara Damodar, Kanaparthy Suneel
Diynes are identified as exceptionally potent and superior substrates in gold-catalyzed organic transformations. Gold (I) and gold (III) complexes exhibit unique activity towards diynes, encouraging the nucleophilic addition of different functional groups both inter and intra- molecularly. In this review, particularly, we focused on recent advances in gold-catalyzed reactions of 1,5-diynes along with
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A Mini Review on Practical Synthesis of Muscimol and its Fluorinated Analogues Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-05-04 Mohd Abdul Fatah Abdul manan
: Since the isolation and structural determination of muscimol, diverse chemical synthetic methods have been developed for the synthesis of the compound and its fluorinated derivatives such as fluoromuscimol and trifluoromethylmuscimol. These classes of compounds have been extensively employed as important building blocks in the design of drugs and pharmaceutical compounds with a broad spectrum of
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Transition Metal-free α-C-H Functionalization of Tertiary Amines Catalysed/ Promoted by Acids: A Brief Review Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-04-28 Mohit L. Deb, Pranjal K. Baruah
C-H Functionalization of α-carbon of tertiary amines has been of great importance for the past two decades as N-heterocycles can be synthesized by this approach and these heterocycles are highly useful as drugs or drug precursors in the pharmaceutical industry. In this review article, we have summarized only the α-C-H functionalization reactions of tertiary amines that are catalysed or promoted by
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Organocatalyzed Stereoselective Glycosylation: An Overview of the Last Decade Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-04-28 Mildred López, Cecilia Anaya de Parrodi, Gabriela Huelgas, José Daniel Lozada-Ramírez
Even though there has been an important evolution in the synthesis of oligosaccharides, the efficient and stereoselective study of glycosidic bonds through non-toxic, moderate, and inexpensive techniques is one of the most challenging fields in organic synthesis. Glycosyl reactions play a fundamental role in biological material and structure-activity relationships, having numerous medicinal chemistry
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Occurrence, Isolation, Pharmacological Potential, Metabolism, and Toxicity of Myristicin: A Naturally Occurring Alkoxy-Substituted Allylbenzene Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-04-27 Vishaldeep Kaur, Sonia Kaushal, Heena, Divya Utreja
Background: Natural products are secondary metabolites obtained from plants, animals, and microorganisms with diverse chemical structures resulting in diverse biological functions and drug-like properties. Objective: This review article summarizes in detail the occurrence, detection, isolation, various pharmacological properties, metabolism, and toxicity of a natural compound i.e., 5-Allyl-1-methoxy-
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Direct Catalytic Conversion of Aldehydes to Nitriles Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-04-27 Fathiy Mutalabisin, Mohd Rafie Johan, Nader Ghaffari Khaligh
Nitriles are employed in many academic and industrial fields, especially organic synthesis. They are crucial precursors to synthesize aldehydes, amines, amides, carboxylic acids, and tetrazoles. There are many routes to synthesize nitriles from various species such as aldehydes, alcohols and amines. This review summarized the recently developed direct conversion of aldehydes to nitriles, focusing on
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Metformin, Chlorpropamide, and Glibenclamide: Interactions with Metal Ions and Cyclodextrins Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-04-07 Jeovani González-Barbosa, Adrián Ricardo Hipólito-Nájera, Rodolfo Gómez-Balderas, Norma Rodríguez-Laguna, Rosario Moya-Hernández
In the field of Chemistry, it is essential to study molecules with biological activity on chronic degenerative diseases to design drugs that help to improve the health of people with diseases such as diabetes, arterial hypertension, rheumatoid arthritis, cancer, among others; and that in turn may have fewer side effects. Diabetes mellitus is a serious metabolic disorder that affects millions of people
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Synthesis and Biological Activities of Heterocyclic Hybrids Containing Piperidine and Pyridine Moieties: Recent Developments Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-04-04 Gangotri Pemawat, Ayushi Bhatnagar, Rama Kanwar Khangarot
Piperidine and pyridine nuclei are essential heterocyclic systems and act as an essential underpinning for agriculture, medicines, industries, etc. The development of novel methods for the synthesis of these exemplary heterocyclic compounds and their respective hybrids, which show a wide range of biological activities, is a very fascinating theme. The derivatives of these pervasive nuclei are used
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A Review of Functional Composite Materials using PSZ-based Siliconnitride Preceramic Polymer Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-03-15 Jing Xue, Lijuan Zhang, Yongzhao Hou, Dong Wang, Ling Li, Guangwu Wen, Jing Wang
The silicon-nitride ceramics gain a lot of interest for applications under severe conditions due to their thermal stability, thermal shock resistance and chemical stability arising from the threedimensional lattice structure. The silicon-nitride ceramics can be synthesized from silicon-nitride preceramic polymers based on polysilazane (PSZ), as the ability to fabricate ceramic components of specific
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Synthesis and Applications of N-Alkoxymethylated Azaheterocycles Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-03-15 Humaira Y. Gondal, Muhammad Nisar, Zain M. Cheema, Kiran Iqbal, Akhtar Munir, Sadia Zaidi, Ahmed Abbas Khan
Alkoxmethyl heterocycles play a significant role as bioactive compounds in pharmaceutical and bifunctional ligands in synthetic organic chemistry. N-Alkoxmethylation can lead toward multipurpose mixed acetals, natural product precursors, and task-specific functionalized ionic liquids. This report provides a comprehensive account of the synthesis and perspectives applications of alkoxymethyl azaheterocycles
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Tetra-n-Butyl Ammonium Fluoride (TBAF) as an Efficient Catalyst Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-03-01 Mohammed A. Salem, Mohamed H. Helal, Mohammed Al-Ghorbani, Ahmed D.H. Deeb, Eman A. Baz, Moustafa A. Gouda
Tetra-n-butylammonium fluoride (TBAF) is an organic compound with the formula C16H36FN. It can exist as anhydrous or hydrated (C16H42FNO3). It is soluble in water and THF and utilized as a base in the preparation of triple monoamine reuptake inhibitors, conjugated dienoic acid esters, and polyacetylenic glucosides. This review aims to summarize the chemistry of TBAF.
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Synthesis of Oxa-bridged Medium-Sized Carbocyclic Rings Mini-Rev. Org. Chem. (IF 2.3) Pub Date : 2023-03-01 Min-Shou Wang, Min Pu, Xu Li
Natural products with oxa-bridged medium-sized carbocyclic ring structure units play an important role in nature. Therefore, developing novel and efficient methods is essential for synthesizing complex natural products containing oxygen-bridged rings. In this article, progress toward the synthesis of oxygen-bridged seven and eight-membered rings is reviewed in terms of the strategies employed.