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Three-Dimensional Morphology of Polymeric Membranes from Electron Tomography Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2024-03-01 Masoud Ghasemi, Michael Geitner, Agatha O'Connell, Enrique D. Gomez
Recent advances in the water–energy landscape hinge upon our improved understanding of the complex morphology of materials involved in water treatment and energy production. Due to their versatility and tunability for applications ranging from drug delivery to fuel cells, polymeric systems will play a crucial role in shaping the future of water–energy nexus applications. Electron tomography (ET) stands
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Biofilms for Production of Chemicals and Energy Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2024-02-21 Janek Weiler, Miriam Edel, Johannes Gescher
The twenty-first century will be the century of biology. This is not only because of breakthrough advances in molecular biology tools but also because we need to reinvent our economy based on the biological principles of energy efficiency and sustainability. Consequently, new tools for production routines must be developed to help produce platform chemicals and energy sources based on sustainable resources
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Mechanism-Driven Design of Multispecific Antibodies for Targeted Disease Treatment Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2024-01-26 Justyn Fine, Bunyarit Meksiriporn, Jiacheng Tan, Jamie B. Spangler
Antibody-based therapeutics constitute a rapidly growing class of pharmaceutical compounds. However, monoclonal antibodies, which specifically engage only one target, often lack the mechanistic intricacy to treat complex diseases. To expand the utility of antibody therapies, significant efforts have been invested in designing multispecific antibodies, which engage multiple targets using a single molecule
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Models for Decarbonization in the Chemical Industry Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2024-01-25 Yuan Yao, Kai Lan, Thomas E. Graedel, Narasimha D. Rao
Various technologies and strategies have been proposed to decarbonize the chemical industry. Assessing the decarbonization, environmental, and economic implications of these technologies and strategies is critical to identifying pathways to a more sustainable industrial future. This study reviews recent advancements and integration of systems analysis models, including process analysis, material flow
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Designing Multivalent and Multispecific Biologics Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2023-12-08 Jennifer J. Kang, Ayako Ohoka, Casim A. Sarkar
In the era of precision medicine, multivalent and multispecific therapeutics present a promising approach for targeted disease intervention. These therapeutics are designed to interact with multiple targets simultaneously, promising enhanced efficacy, reduced side effects, and resilience against drug resistance. We dissect the principles guiding the design of multivalent biologics, highlighting challenges
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Reassessing the Standard Chemotaxis Framework for Understanding Biased Migration in Helicobacter pylori Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2023-12-04 Jyot D. Antani, Aakansha Shaji, Rachit Gupta, Pushkar P. Lele
Helicobacter pylori infections are a major cause of peptic ulcers and gastric cancers. The development of robust inflammation in response to these flagellated, motile bacteria is correlated with poor prognosis. Chemotaxis plays a crucial role in H. pylori colonization, enabling the bacteria to swim toward favorable chemical environments. Unlike the model species of bacterial chemotaxis, Escherichia
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Nonconjugated Redox-Active Polymers: Electron Transfer Mechanisms, Energy Storage, and Chemical Versatility Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2023-06-08 Ting Ma, Alexandra D. Easley, Ratul Mitra Thakur, Khirabdhi T. Mohanty, Chen Wang, Jodie L. Lutkenhaus
The storage of electric energy in a safe and environmentally friendly way is of ever-growing importance for a modern, technology-based society. With future pressures predicted for batteries that contain strategic metals, there is increasing interest in metal-free electrode materials. Among candidate materials, nonconjugated redox-active polymers (NC-RAPs) have advantages in terms of cost-effectiveness
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RNAs as Sensors of Oxidative Stress in Bacteria Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2023-06-08 Ryan Buchser, Phillip Sweet, Aparna Anantharaman, Lydia Contreras
Oxidative stress is an important and pervasive physical stress encountered by all kingdoms of life, including bacteria. In this review, we briefly describe the nature of oxidative stress, highlight well-characterized protein-based sensors (transcription factors) of reactive oxygen species that serve as standards for molecular sensors in oxidative stress, and describe molecular studies that have explored
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Engineering Innovations, Challenges, and Opportunities for Lignocellulosic Biorefineries: Leveraging Biobased Polymer Production Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2023-04-11 Alison J. Shapiro, Robert M. O'Dea, Sonia C. Li, Jamael C. Ajah, Garrett F. Bass, Thomas H. Epps
Alternative polymer feedstocks are highly desirable to address environmental, social, and security concerns associated with petrochemical-based materials. Lignocellulosic biomass (LCB) has emerged as one critical feedstock in this regard because it is an abundant and ubiquitous renewable resource. LCB can be deconstructed to generate valuable fuels, chemicals, and small molecules/oligomers that are
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Role of International Oil Companies in the Net-Zero Emission Energy Transition Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2023-03-21 Dirk J. Smit, Joseph B. Powell
Scientific and engineering capabilities in hydrocarbon supply chains developed over decades in international oil and gas companies (IOCs) uniquely position these companies to drive rapid scale-up and transition to a net-zero emission economy. Flexible large-scale production of energy carriers such as hydrogen, ammonia, methanol, and other synthetic fuels produced with low- or zero-emission renewable
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Combining Machine Learning with Physical Knowledge in Thermodynamic Modeling of Fluid Mixtures Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2023-03-21 Fabian Jirasek, Hans Hasse
Thermophysical properties of fluid mixtures are important in many fields of science and engineering. However, experimental data are scarce in this field, so prediction methods are vital. Different types of physical prediction methods are available, ranging from molecular models over equations of state to models of excess properties. These well-established methods are currently being complemented by
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Electrochemical Manufacturing Routes for Organic Chemical Commodities Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2023-03-17 Ricardo Mathison, Alexandra L. Ramos Figueroa, Casey Bloomquist, Miguel A. Modestino
Electrochemical synthesis of organic chemical commodities provides an alternative to conventional thermochemical manufacturing and enables the direct use of renewable electricity to reduce greenhouse gas emissions from the chemical industry. We discuss electrochemical synthesis approaches that use abundant carbon feedstocks for the production of the largest petrochemical precursors and basic organic
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Active Colloids as Models, Materials, and Machines Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2023-03-17 Kyle J.M. Bishop, Sibani Lisa Biswal, Bhuvnesh Bharti
Active colloids use energy input at the particle level to propel persistent motion and direct dynamic assemblies. We consider three types of colloids animated by chemical reactions, time-varying magnetic fields, and electric currents. For each type, we review the basic propulsion mechanisms at the particle level and discuss their consequences for collective behaviors in particle ensembles. These microscopic
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Outsmarting Pathogens with Antibody Engineering Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2023-03-14 Ahlam N. Qerqez, Rui P. Silva, Jennifer A. Maynard
There is growing interest in identifying antibodies that protect against infectious diseases, especially for high-risk individuals and pathogens for which no vaccine is yet available. However, pathogens that manifest as opportunistic or latent infections express complex arrays of virulence-associated proteins and are adept at avoiding immune responses. Some pathogens have developed strategies to selectively
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Drying Drops of Colloidal Dispersions Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2023-03-14 Sumesh P. Thampi, Madivala G. Basavaraj
Drying drops of colloidal dispersions have attracted attention from researchers since the nineteenth century. The multiscale nature of the problem involving physics at different scales, namely colloidal and interfacial phenomena as well as heat, mass, and momentum transport processes, combined with the seemingly simple yet nontrivial shape of the drops makes drying drop problems rich and interesting
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Scale-Up of Photochemical Reactions: Transitioning from Lab Scale to Industrial Production Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2023-03-13 Stefan D.A. Zondag, Daniele Mazzarella, Timothy Noël
In the past two decades, we have witnessed a rapid emergence of new and powerful photochemical and photocatalytic synthetic methods. Although these methods have been used mostly on a small scale, there is a growing need for efficient scale-up of photochemistry in the chemical industry. This review summarizes and contextualizes the advancements made in the past decade regarding the scale-up of photo-mediated
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Everything You Wanted to Know about Deep Eutectic Solvents but Were Afraid to Be Told Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2023-03-08 Dinis O. Abranches, João A.P. Coutinho
Are deep eutectic solvents (DESs) a promising alternative to conventional solvents? Perhaps, but their development is hindered by a plethora of misconceptions. These are carefully analyzed here, beginning with the very meaning of DESs, which has strayed far beyond its original scope of eutectic mixtures of Lewis or Brønsted acids and bases. Instead, a definition that is grounded on thermodynamic principles
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Peptide-Based Vectors: A Biomolecular Engineering Strategy for Gene Delivery Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2023-03-08 Sandeep Urandur, Millicent O. Sullivan
From the first clinical trial by Dr. W.F. Anderson to the most recent US Food and Drug Administration–approved Luxturna (Spark Therapeutics, 2017) and Zolgensma (Novartis, 2019), gene therapy has revamped thinking and practice around cancer treatment and improved survival rates for adult and pediatric patients with genetic diseases. A major challenge to advancing gene therapies for a broader array
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In Situ/Operando Characterization Techniques of Electrochemical CO2 Reduction Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2023-03-08 Bjorn Hasa, Yaran Zhao, Feng Jiao
Electrocatalytic conversion of carbon dioxide to valuable chemicals and fuels driven by renewable energy plays a crucial role in achieving net-zero carbon emissions. Understanding the structure–activity relationship and the reaction mechanism is significant for tuning electrocatalyst selectivity. Therefore, characterizing catalyst dynamic evolution and reaction intermediates under reaction conditions
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Engineering Next-Generation CAR-T Cells: Overcoming Tumor Hypoxia and Metabolism Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-06-21 Torahito A. Gao, Yvonne Y. Chen
T cells engineered to express chimeric antigen receptors (CARs) have shown remarkable success in treating B-cell malignancies, reflected by multiple US Food and Drug Administration–approved CAR-T cell products currently on the market. However, various obstacles have thus far limited the use of approved products and constrained the efficacy of CAR-T cell therapy against solid tumors. Overcoming these
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Liquid-Phase Transmission Electron Microscopy for Reliable In Situ Imaging of Nanomaterials Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-06-21 Jongbaek Sung, Yuna Bae, Hayoung Park, Sungsu Kang, Back Kyu Choi, Joodeok Kim, Jungwon Park
Liquid-phase transmission electron microscopy (LPTEM) is a powerful in situ visualization technique for directly characterizing nanomaterials in the liquid state. Despite its successful application in many fields, several challenges remain in achieving more accurate and reliable observations. We present LPTEM in chemical and biological applications, including studies for the morphological transformation
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Transformation of Biopharmaceutical Manufacturing Through Single-Use Technologies: Current State, Remaining Challenges, and Future Development Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-06-21 Jasmin J. Samaras, Martina Micheletti, Weibing Ding
Single-use technologies have transformed conventional biopharmaceutical manufacturing, and their adoption is increasing rapidly for emerging applications like antibody–drug conjugates and cell and gene therapy products. These disruptive technologies have also had a significant impact during the coronavirus disease 2019 pandemic, helping to advance process development to enable the manufacturing of
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Engineering Next-Generation CAR-T Cells: Overcoming Tumor Hypoxia and Metabolism Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-06-10 Torahito A. Gao, Yvonne Y. Chen
T cells engineered to express chimeric antigen receptors (CARs) have shown remarkable success in treating B-cell malignancies, reflected by multiple US Food and Drug Administration–approved CAR-T cell products currently on the market. However, various obstacles have thus far limited the use of approved products and constrained the efficacy of CAR-T cell therapy against solid tumors. Overcoming these
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Liquid-Phase Transmission Electron Microscopy for Reliable In Situ Imaging of Nanomaterials Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-06-10 Jongbaek Sung, Yuna Bae, Hayoung Park, Sungsu Kang, Back Kyu Choi, Joodeok Kim, Jungwon Park
Liquid-phase transmission electron microscopy (LPTEM) is a powerful in situ visualization technique for directly characterizing nanomaterials in the liquid state. Despite its successful application in many fields, several challenges remain in achieving more accurate and reliable observations. We present LPTEM in chemical and biological applications, including studies for the morphological transformation
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Transformation of Biopharmaceutical Manufacturing Through Single-Use Technologies: Current State, Remaining Challenges, and Future Development Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-06-10 Jasmin J. Samaras, Martina Micheletti, Weibing Ding
Single-use technologies have transformed conventional biopharmaceutical manufacturing, and their adoption is increasing rapidly for emerging applications like antibody–drug conjugates and cell and gene therapy products. These disruptive technologies have also had a significant impact during the coronavirus disease 2019 pandemic, helping to advance process development to enable the manufacturing of
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Hydrogen Production and Its Applications to Mobility Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-04-13 Andres Gonzalez-Garay, Mai Bui, Diego Freire Ordóñez, Michael High, Adam Oxley, Nadine Moustafa, Paola A. Sáenz Cavazos, Piera Patrizio, Nixon Sunny, Niall Mac Dowell, Nilay Shah
Hydrogen has been identified as one of the key elements to bolster longer-term climate neutrality and strategic autonomy for several major countries. Multiple road maps emphasize the need to accelerate deployment across its supply chain and utilization. Being one of the major contributors to global CO2 emissions, the transportation sector finds in hydrogen an appealing alternative to reach sustainable
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Zeolitic Imidazolate Framework Membranes: Novel Synthesis Methods and Progress Toward Industrial Use Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-04-13 Dennis T. Lee, Peter Corkery, Sunghwan Park, Hae-Kwon Jeong, Michael Tsapatsis
In the last decade, zeolitic imidazolate frameworks (ZIFs) have been studied extensively for their potential as selective separation membranes. In this review, we highlight unique structural properties of ZIFs that allow them to achieve certain important separations, like that of propylene from propane, and summarize the state of the art in ZIF thin-film deposition on porous substrates and their modification
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Medical 3D Printing: Tools and Techniques, Today and Tomorrow Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-04-06 Kelsey Willson, Anthony Atala
Three-dimensional printing is a still-emerging technology with high impact for the medical community, particularly in the development of tissues for the clinic. Many types of printers are under development, including extrusion, droplet, melt, and light-curing technologies. Herein we discuss the various types of 3D printers and their strengths and weaknesses concerning tissue engineering. Despite the
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Lessons from Biomass Valorization for Improving Plastic-Recycling Enzymes Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-04-04 Margarida Gomes, Yannick Rondelez, Ludwik Leibler
Synthetic polymers such as plastics exhibit numerous advantageous properties that have made them essential components of our daily lives, with plastic production doubling every 15 years. The relatively low cost of petroleum-based polymers encourages their single use and overconsumption. Synthetic plastics are recalcitrant to biodegradation, and mismanagement of plastic waste leads to their accumulation
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Multilevel Mesoscale Complexities in Mesoregimes: Challenges in Chemical and Biochemical Engineering Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-04-04 Jianhua Chen, Ying Ren, Wen Lai Huang, Lin Zhang, Jinghai Li
This review discusses the complex behaviors in diverse chemical and biochemical systems to elucidate their commonalities and thus help develop a mesoscience methodology to address the complexities in even broader topics. This could possibly build a new scientific paradigm for different disciplines and could meanwhile provide effective tools to tackle the big challenges in various fields, thus paving
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Blockchain Technology in the Chemical Industry Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-04-01 Xiaochi Zhou, Markus Kraft
This article presents a review of the application of blockchain and blockchain-based smart contracts in the chemical and related industries. We introduce the basic concepts of blockchain and smart contracts and explain how some of their features are enabled. We review several typical or novel applications of blockchain and smart contract technologies and their enabling concepts and underlying technologies
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Technological Options for Direct Air Capture: A Comparative Process Engineering Review Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-04-01 Xiaowei Wu, Ramanan Krishnamoorti, Praveen Bollini
The direct capture of CO2 from ambient air presents a means of decelerating the growth of global atmospheric CO2 concentrations. Considerations relating to process engineering are the focus of this review and have received significantly less attention than those relating to the design of materials for direct air capture (DAC). We summarize minimum thermodynamic energy requirements, second law efficiencies
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Nanotherapeutics and the Brain Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-03-23 Andrea Joseph, Elizabeth Nance
Brain disease remains a significant health, social, and economic burden with a high failure rate of translation of therapeutics to the clinic. Nanotherapeutics have represented a promising area of technology investment to improve drug bioavailability and delivery to the brain, with several successes for nanotherapeutic use for central nervous system disease that are currently in the clinic. However
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Machine Learning for the Discovery, Design, and Engineering of Materials Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-03-23 Chenru Duan, Aditya Nandy, Heather J. Kulik
Machine learning (ML) has become a part of the fabric of high-throughput screening and computational discovery of materials. Despite its increasingly central role, challenges remain in fully realizing the promise of ML. This is especially true for the practical acceleration of the engineering of robust materials and the development of design strategies that surpass trial and error or high-throughput
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The Critical Role of Process Analysis in Chemical Recycling and Upcycling of Waste Plastics Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-03-23 Scott R. Nicholson, Julie E. Rorrer, Avantika Singh, Mikhail O. Konev, Nicholas A. Rorrer, Alberta C. Carpenter, Alan J. Jacobsen, Yuriy Román-Leshkov, Gregg T. Beckham
There is an urgent need for new technologies to enable circularity for synthetic polymers, spurred by the accumulation of waste plastics in landfills and the environment and the contributions of plastics manufacturing to climate change. Chemical recycling is a promising means to convert waste plastics into molecular intermediates that can be remanufactured into new products. Given the growing interest
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Optogenetics Illuminates Applications in Microbial Engineering Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-03-23 Shannon M. Hoffman, Allison Y. Tang, José L. Avalos
Optogenetics has been used in a variety of microbial engineering applications, such as chemical and protein production, studies of cell physiology, and engineered microbe–host interactions. These diverse applications benefit from the precise spatiotemporal control that light affords, as well as its tunability, reversibility, and orthogonality. This combination of unique capabilities has enabled a surge
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Advances in Manufacturing Cardiomyocytes from Human Pluripotent Stem Cells Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-03-23 Martha E. Floy, Fathima Shabnam, Aaron D. Simmons, Vijesh J. Bhute, Gyuhyung Jin, Will A. Friedrich, Alexandra B. Steinberg, Sean P. Palecek
The emergence of human pluripotent stem cell (hPSC) technology over the past two decades has provided a source of normal and diseased human cells for a wide variety of in vitro and in vivo applications. Notably, hPSC-derived cardiomyocytes (hPSC-CMs) are widely used to model human heart development and disease and are in clinical trials for treating heart disease. The success of hPSC-CMs in these applications
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Direct Air Capture of CO2Using Solvents Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-03-19 Radu Custelcean
Large-scale deployment of negative emissions technologies (NETs) that permanently remove CO2from the atmosphere is now considered essential for limiting the global temperature increase to less than 2°C by the end of this century. One promising NET is direct air capture (DAC), a technology that employs engineered chemical processes to remove atmospheric carbon dioxide, potentially at the scale of billions
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Biopharmaceutical Manufacturing: Historical Perspectives and Future Directions Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-03-18 Alana C. Szkodny, Kelvin H. Lee
This review describes key milestones related to the production of biopharmaceuticals—therapies manufactured using recombinant DNA technology. The market for biopharmaceuticals has grown significantly since the first biopharmaceutical approval in 1982, and the scientific maturity of the technologies used in their manufacturing processes has grown concomitantly. Early processes relied on established
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Airborne Transmission of SARS-CoV-2: Evidence and Implications for Engineering Controls Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-03-18 V. Faye McNeill
Since late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally, causing a pandemic (coronavirus disease 2019, or COVID-19) with dire consequences, including widespread death, long-term illness, and societal and economic disruption. Although initially uncertain, evidence is now overwhelming that SARS-CoV-2 is transmitted primarily through small respiratory droplets
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Interferometric Probing of Physical and Chemical Properties of Solutions: Noncontact Investigation of Liquids Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-03-18 Cornelia Eder, Heiko Briesen
Interferometry is a highly versatile tool for probing physical and chemical phenomena. In addition to the benefit of noncontact investigations, even spatially resolved information can be obtained by choosing a suitable setup. This review presents the evolution of the various setups that have evolved since the first interferometers were developed in the mid-nineteenth century and highlights the benefits
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Machine Learning–Assisted Design of Material Properties Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-03-18 Sanket Kadulkar, Zachary M. Sherman, Venkat Ganesan, Thomas M. Truskett
Designing functional materials requires a deep search through multidimensional spaces for system parameters that yield desirable material properties. For cases where conventional parameter sweeps or trial-and-error sampling are impractical, inverse methods that frame design as a constrained optimization problem present an attractive alternative. However, even efficient algorithms require time- and
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Flow Chemistry: A Sustainable Voyage Through the Chemical Universe en Route to Smart Manufacturing Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-03-09 Amanda A. Volk, Zachary S. Campbell, Malek Y.S. Ibrahim, Jeffrey A. Bennett, Milad Abolhasani
Microfluidic devices and systems have entered many areas of chemical engineering, and the rate of their adoption is only increasing. As we approach and adapt to the critical global challenges we face in the near future, it is important to consider the capabilities of flow chemistry and its applications in next-generation technologies for sustainability, energy production, and tailor-made specialty
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Biosynthesis of Isonitrile- and Alkyne-Containing Natural Products Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-03-03 Antonio Del Rio Flores, Colin C. Barber, Maanasa Narayanamoorthy, Di Gu, Yuanbo Shen, Wenjun Zhang
Natural products are a diverse class of biologically produced compounds that participate in fundamental biological processes such as cell signaling, nutrient acquisition, and interference competition. Unique triple-bond functionalities like isonitriles and alkynes often drive bioactivity and may serve as indicators of novel chemical logic and enzymatic machinery. Yet, the biosynthetic underpinnings
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Data-Driven Design and Autonomous Experimentation in Soft and Biological Materials Engineering Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2022-03-03 Andrew L. Ferguson, Keith A. Brown
This article reviews recent developments in the applications of machine learning, data-driven modeling, transfer learning, and autonomous experimentation for the discovery, design, and optimization of soft and biological materials. The design and engineering of molecules and molecular systems have long been a preoccupation of chemical and biomolecular engineers using a variety of computational and
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Small-Scale Phenomena in Reactive Bubbly Flows: Experiments, Numerical Modeling, and Applications Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2021-06-07 Michael Schlüter, Sonja Herres-Pawlis, Ulrich Nieken, Ute Tuttlies, Dieter Bothe
Improving the yield and selectivity of chemical reactions is one of the challenging tasks in paving the way for a more sustainable and climate-friendly economy. For the industrially highly relevant gas–liquid reactions, this can be achieved by tailoring the timescales of mixing to the requirements of the reaction. Although this has long been known for idealized reactors and time- and space-averaged
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Crystal Structure Prediction Methods for Organic Molecules: State of the Art Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2021-06-07 David H. Bowskill, Isaac J. Sugden, Stefanos Konstantinopoulos, Claire S. Adjiman, Constantinos C. Pantelides
The prediction of the crystal structures that a given organic molecule is likely to form is an important theoretical problem of significant interest for the pharmaceutical and agrochemical industries, among others. As evidenced by a series of six blind tests organized over the past 2 decades, methodologies for crystal structure prediction (CSP) have witnessed substantial progress and have now reached
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Recent Developments in Solvent-Based Fluid Separations Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2021-06-07 Boelo Schuur, Thomas Brouwer, Lisette M.J. Sprakel
The most important developments in solvent-based fluid separations, separations involving at least one fluid phase, are reviewed. After a brief introduction and discussion on general solvent trends observed in all fields of application, several specific fields are discussed. Important solvent trends include replacement of traditional molecular solvents by ionic liquids and deep eutectic solvents and
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Reactive Flows in Porous Media: Challenges in Theoretical and Numerical Methods Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2021-06-07 Anthony J.C. Ladd, Piotr Szymczak
We review theoretical and computational research, primarily from the past 10 years, addressing the flow of reactive fluids in porous media. The focus is on systems where chemical reactions at the solid–fluid interface cause dissolution of the surrounding porous matrix, creating nonlinear feedback mechanisms that can often lead to greatly enhanced permeability. We discuss insights into the evolution
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Dynamic Control of Metabolism Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2021-06-07 Cynthia Ni, Christina V. Dinh, Kristala L.J. Prather
Metabolic engineering reprograms cells to synthesize value-added products. In doing so, endogenous genes are altered and heterologous genes can be introduced to achieve the necessary enzymatic reactions. Dynamic regulation of metabolic flux is a powerful control scheme to alleviate and overcome the competing cellular objectives that arise from the introduction of these production pathways. This review
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Liquid–Liquid Chromatography: Current Design Approaches and Future Pathways Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2021-06-07 Raena Morley, Mirjana Minceva
Since its first appearance in the 1960s, solid support–free liquid–liquid chromatography has played an ever-growing role in the field of natural products research. The use of the two phases of a liquid biphasic system, the mobile and stationary phases, renders the technique highly versatile and adaptable to a wide spectrum of target molecules, from hydrophobic to highly polar small molecules to proteins
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Storage of Carbon Dioxide in Saline Aquifers: Physicochemical Processes, Key Constraints, and Scale-Up Potential Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2021-06-07 Philip S. Ringrose, Anne-Kari Furre, Stuart M.V. Gilfillan, Samuel Krevor, Martin Landrø, Rory Leslie, Tip Meckel, Bamshad Nazarian, Adeel Zahid
CO2 storage in saline aquifers offers a realistic means of achieving globally significant reductions in greenhouse gas emissions at the scale of billions of tonnes per year. We review insights into the processes involved using well-documented industrial-scale projects, supported by a range of laboratory analyses, field studies, and flow simulations. The main topics we address are (a) the significant
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Stepping on the Gas to a Circular Economy: Accelerating Development of Carbon-Negative Chemical Production from Gas Fermentation Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2021-06-07 Nick Fackler, Björn D. Heijstra, Blake J. Rasor, Hunter Brown, Jacob Martin, Zhuofu Ni, Kevin M. Shebek, Rick R. Rosin, Séan D. Simpson, Keith E. Tyo, Richard J. Giannone, Robert L. Hettich, Timothy J. Tschaplinski, Ching Leang, Steven D. Brown, Michael C. Jewett, Michael Köpke
Owing to rising levels of greenhouse gases in our atmosphere and oceans, climate change poses significant environmental, economic, and social challenges globally. Technologies that enable carbon capture and conversion of greenhouse gases into useful products will help mitigate climate change by enabling a new circular carbon economy. Gas fermentation usingcarbon-fixing microorganisms offers an economically
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Polymer-Infiltrated Nanoparticle Films Using Capillarity-Based Techniques: Toward Multifunctional Coatings and Membranes Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2021-06-07 R. Bharath Venkatesh, Neha Manohar, Yiwei Qiang, Haonan Wang, Hong Huy Tran, Baekmin Q. Kim, Anastasia Neuman, Tian Ren, Zahra Fakhraai, Robert A. Riggleman, Kathleen J. Stebe, Kevin Turner, Daeyeon Lee
Polymer-infiltrated nanoparticle films (PINFs) are a new class of nanocomposites that offer synergistic properties and functionality derived from unusually high fractions of nanomaterials. Recently, two versatile techniques,capillary rise infiltration (CaRI) and solvent-driven infiltration of polymer (SIP), have been introduced that exploit capillary forces in films of densely packed nanoparticles
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Tough Double Network Hydrogel and Its Biomedical Applications Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2021-06-07 Takayuki Nonoyama, Jian Ping Gong
Soft and wet hydrogels have many similarities to biological tissues, though their mechanical fragility had been one of the biggest obstacles in biomedical applications. Studies and developments in double network (DN) hydrogels have elucidated how to create tough gels universally based on sacrificial bond principles and opened a path for biomedical application of hydrogels in regenerative medicine and
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Wearable and Implantable Soft Bioelectronics: Device Designs and Material Strategies Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2021-06-07 Sung-Hyuk Sunwoo, Kyoung-Ho Ha, Sangkyu Lee, Nanshu Lu, Dae-Hyeong Kim
High-performance wearable and implantable devices capable of recording physiological signals and delivering appropriate therapeutics in real time are playing a pivotal role in revolutionizing personalized healthcare. However, the mechanical and biochemical mismatches between rigid, inorganic devices and soft, organic human tissues cause significant trouble, including skin irritation, tissue damage
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Solid-Binding Proteins: Bridging Synthesis, Assembly, and Function in Hybrid and Hierarchical Materials Fabrication Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2021-06-07 Karthik Pushpavanam, Jinrong Ma, Yifeng Cai, Nada Y. Naser, François Baneyx
There is considerable interest in the development of hybrid organic–inorganic materials because of the potential for harvesting the unique capabilities that each system has to offer. Proteins are an especially attractive organic component owing to the high amount of chemical information encoded in their amino acid sequence, their amenability to molecular and computational (re)design, and the many structures
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Phagosome–Bacteria Interactions from the Bottom Up Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2021-06-07 Darshan M. Sivaloganathan, Mark P. Brynildsen
When attempting to propagate infections, bacterial pathogens encounter phagocytes that encase them in vacuoles called phagosomes. Within phagosomes, bacteria are bombarded with a plethora of stresses that often lead to their demise. However, pathogens have evolved numerous strategies to counter those host defenses and facilitate survival. Given the importance of phagosome–bacteria interactions to infection
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Bottom-Up Synthesis of Artificial Cells: Recent Highlights and Future Challenges Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2021-06-07 Ivan Ivanov, Sebastián López Castellanos, Severo Balasbas III, Lado Otrin, Nika Marušič, Tanja Vidaković-Koch, Kai Sundmacher
The bottom-up approach in synthetic biology aims to create molecular ensembles that reproduce the organization and functions of living organisms and strives to integrate them in a modular and hierarchical fashion toward the basic unit of life—the cell—and beyond. This young field stands on the shoulders of fundamental research in molecular biology and biochemistry, next to synthetic chemistry, and
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RNA Engineering for Public Health: Innovations in RNA-Based Diagnostics and Therapeutics Annu. Rev. Chem. Biomol. Eng. (IF 8.4) Pub Date : 2021-06-07 Walter Thavarajah, Laura M. Hertz, David Z. Bushhouse, Chloé M. Archuleta, Julius B. Lucks
RNA is essential for cellular function: From sensing intra- and extracellular signals to controlling gene expression, RNA mediates a diverse and expansive list of molecular processes. A long-standing goal of synthetic biology has been to develop RNA engineering principles that can be used to harness and reprogram these RNA-mediated processes to engineer biological systems to solve pressing global challenges