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Self-actuating inflammation responsive hydrogel microsphere formulation for controlled drug release in rheumatoid arthritis (RA): Animal trials and study in human fibroblast like synoviocytes (hFLS) of RA patients Biomater. Adv. (IF 7.9) Pub Date : 2024-04-16 Raghuraj Singh, Krishna Jadhav, Rohit Kamboj, Hitesh Malhotra, Eupa Ray, Agrim Jhilta, Varun Dhir, Rahul Kumar Verma
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Targeted drug-loaded peptides induce tumor cell apoptosis and immunomodulation to increase antitumor efficacy Biomater. Adv. (IF 7.9) Pub Date : 2024-04-16 Hongjie Li, Peirong Zhang, Xiaomeng Yuan, Shan Peng, Xingyue Yang, Yuxia Li, Zhen Shen, Jingkun Bai
Immunotherapy is an emerging approach for the treatment of solid tumors. Although chemotherapy is generally considered immunosuppressive, specific chemotherapeutic agents can induce tumor immunity. In this study, we developed a targeted, acid-sensitive peptide nanoparticle (DT/Pep1) to deliver doxorubicin (DOX) and triptolide (TPL) to breast cancer cells the enhanced permeability and retention (EPR)
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Glioblastoma mechanobiology at multiple length scales Biomater. Adv. (IF 7.9) Pub Date : 2024-04-15 Raghu Vamsi Kondapaneni, Sumiran Kumar Gurung, Pinaki S. Nakod, Kasra Goodarzi, Venu Yakati, Nicholas A. Lenart, Shreyas S. Rao
Glioblastoma multiforme (GBM), a primary brain cancer, is one of the most aggressive forms of human cancer, with a very low patient survival rate. A characteristic feature of GBM is the diffuse infiltration of tumor cells into the surrounding brain extracellular matrix (ECM) that provide biophysical, topographical, and biochemical cues. In particular, ECM stiffness and composition is known to play
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High-strength double-network silk fibroin based hydrogel loaded with Icariin and BMSCs to inhibit osteoclasts and promote osteogenic differentiation to enhance bone repair Biomater. Adv. (IF 7.9) Pub Date : 2024-04-12 Huiling Liu, Yang Jiao, T. Forouzanfar, Gang Wu, Rui Guo, Haiyan Lin
Large bone defects cause significant clinical challenges due to the lack of optimal grafts for effective regeneration. The tissue engineering way that requires the combination of biomaterials scaffold, stem cells and proper bioactive factors is a prospective method for large bone repair. Here, we synthesized a three-arm host-guest supramolecule (HGSM) to covalently crosslinking with the naturally derived
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Chemistry matters: A side-by-side comparison of two chemically distinct methacryloylated dECM bioresins for vat photopolymerization Biomater. Adv. (IF 7.9) Pub Date : 2024-04-07 Ahed Almalla, Laura Elomaa, Nora Fribiczer, Timm Landes, Peng Tang, Zeinab Mahfouz, Beate Koksch, Karl Herbert Hillebrandt, Igor Maximilian Sauer, Dag Heinemann, Sebastian Seiffert, Marie Weinhart
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“A lactose-modified chitosan accelerates chondrogenic differentiation in mesenchymal stem cells spheroids” Biomater. Adv. (IF 7.9) Pub Date : 2024-04-04 F. Scognamiglio, C. Pizzolitto, M. Romano, G. Teti, S. Zara, M. Conz, I. Donati, D. Porrelli, M. Falconi, E. Marsich
Spheroids derived from human mesenchymal stem cells (hMSCs) are of limited use for cartilage regeneration, as the viability of the cells progressively decreases during the period required for chondrogenic differentiation (21 days). In this work, spheroids based on hMSCs and a lactose-modified chitosan (CTL) were formed by seeding cells onto an air-dried coating of CTL. The polymer coating can inhibit
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A composite hydrogel loaded with the processed pyritum promotes bone repair via stimulate the osteogenic differentiation of BMSCs Biomater. Adv. (IF 7.9) Pub Date : 2024-04-02 Xingyu Zhu, Huanjin Liu, Chunmei Mei, Fugui Chen, Mengyu Guo, Chenxu Wei, Dan Wang, Meimei Luo, Xiaofang Hu, Yuwei Zhao, Fangyu Hao, Changcan Shi, Weidong Li
Tissue engineering shows promise in repairing extensive bone defects. The promotion of proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) by biological scaffolds has a significant impact on bone regeneration outcomes. In this study we used an injectable hydrogel, known as aminated mesoporous silica gel composite hydrogel (MSNs-NH@GelMA), loaded with a natural
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Remarkable enhancement of cinnamaldehyde antimicrobial activity encapsulated in capped mesoporous nanoparticles: A new “nanokiller” approach in the era of antimicrobial resistance Biomater. Adv. (IF 7.9) Pub Date : 2024-03-26 Ángela Morellá-Aucejo, Serena Medaglia, María Ruiz-Rico, Ramón Martínez-Máñez, María Dolores Marcos, Andrea Bernardos
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Dynamic light-responsive RhoA activity regulates mechanosensitive stem cell fate decision in 3D matrices Biomater. Adv. (IF 7.9) Pub Date : 2024-03-25 Jieung Baek, Sanjay Kumar, David V. Schaffer
The behavior of stem cells is regulated by mechanical cues in their niche that continuously vary due to extracellular matrix (ECM) remodeling, pulsated mechanical stress exerted by blood flow, and/or cell migration. However, it is still unclear how dynamics of mechanical cues influence stem cell lineage commitment, especially in a 3D microenvironment where mechanosensing differs from that in a 2D microenvironment
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Aerosolization of poly(sulfobetaine) microparticles that encapsulate therapeutic antibodies Biomater. Adv. (IF 7.9) Pub Date : 2024-03-25 Songpei Xie, Amir Erfani, Saeed Manouchehri, Joshua Ramsey, Clint Aichele
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Antibacterial and self-healing sepiolite-based hybrid hydrogel for hemostasis and wound healing Biomater. Adv. (IF 7.9) Pub Date : 2024-03-23 Yizhi Jiang, Li Wang, Wangdan Qi, Peisheng Yin, Xiang Liao, Yuze Luo, Yanhuai Ding
The process of wound healing necessitates a specific environment, thus prompting extensive research into the utilization of hydrogels for this purpose. While numerous hydrogel structures have been investigated, the discovery of a self-healing hydrogel possessing favorable biocompatibility, exceptional mechanical properties, and effective hemostatic and antibacterial performance remains uncommon. In
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Wireless electrostimulation for cancer treatment: An integrated nanoparticle/coaxial fiber mesh platform Biomater. Adv. (IF 7.9) Pub Date : 2024-03-22 Leonor Resina, Fábio F.F. Garrudo, Carlos Alemán, Teresa Esteves, Frederico Castelo Ferreira
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ROS mediated Cu[Fe(CN)5NO] nanoparticles for triple negative breast cancer: A detailed study in preclinical mouse model Biomater. Adv. (IF 7.9) Pub Date : 2024-03-21 Sanchita Tripathy, Shagufta Haque, Swapnali Londhe, Sourav Das, Caroline Celine Norbert, Yogesh Chandra, Bojja Sreedhar, Chitta Ranjan Patra
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AS1411 aptamer/RGD dual functionalized theranostic chitosan-PLGA nanoparticles for brain cancer treatment and imaging Biomater. Adv. (IF 7.9) Pub Date : 2024-03-20 Mahima Chauhan, Sonali, Saurabh Shekhar, Bhavna Yadav, Vandana Garg, Rohit Dutt, Abhishesh Kumar Mehata, Pooja Goswami, Biplob Koch, Madaswamy S. Muthu, Rahul Pratap Singh
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Encapsulation of the growth factor neurotrophin-3 in heparinised poloxamer hydrogel stabilises bioactivity and provides sustained release Biomater. Adv. (IF 7.9) Pub Date : 2024-03-20 Svenja Meissner, Shaun Rees, Linh Nguyen, Bronwen Connor, David Barker, Bruce Harland, Brad Raos, Darren Svirskis
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Electrochemical polishing, characterisation and in vitro evaluation of additively manufactured CoCr stents with personalised designs Biomater. Adv. (IF 7.9) Pub Date : 2024-03-20 Ran He, Xuezhi Cao, Enzoh Langi, Lukas Masseling, Felix Vogt, Liguo Zhao
Additive manufacturing (AM) technology has paved the way for manufacturing personalised stents. However, there is a notable gap in comprehensive microstructure analyses and evaluations of the AM CoCr stents using advanced methodologies. To address this gap, this study focuses on investigating the microstructure and performance of personalised CoCr stents manufactured through micro-laser powder bed
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Improved hydration property of tissue adhesive/hemostatic microparticle based on hydrophobically-modified Alaska pollock gelatin Biomater. Adv. (IF 7.9) Pub Date : 2024-03-19 Shima Ito, Kazuhiro Nagasaka, Hiyori Komatsu, Debabrata Palai, Akihiro Nishiguchi, Tetsushi Taguchi
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Application of Doxorubicin-loaded PLGA nanoparticles targeting both tumor cells and cancer-associated fibroblasts on 3D human skin equivalents mimicking melanoma and cutaneous squamous cell carcinoma Biomater. Adv. (IF 7.9) Pub Date : 2024-03-17 Yuanyuan He, Shidi Wu, Marion Rietveld, Maarten Vermeer, Luis J. Cruz, Christina Eich, Abdoelwaheb El Ghalbzouri
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Fast-relaxing hydrogels with reversibly tunable mechanics for dynamic cancer cell culture Biomater. Adv. (IF 7.9) Pub Date : 2024-03-15 Yee Yee Khine, Han Nguyen, Favour Afolabi, Chien-Chi Lin
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The importance of mechanical and biological cues of tympanic membrane grafts to ensure optimal regeneration Biomater. Adv. (IF 7.9) Pub Date : 2024-03-11 Oriana Nobus, Laurens Parmentier, Pieter Livens, Pieter Muyshondt, Krystyna Szewcyk, Christel Jacobs, Dorien Verdoodt, Leen Pieters, Quinten Thijssen, Bo Van Durme, Anne Vral, Joris Dirckx, Vincent Van Rompaey, Sandra Van Vlierberghe
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Angiogenesis in bone tissue engineering via ceramic scaffolds: A review of concepts and recent advancements Biomater. Adv. (IF 7.9) Pub Date : 2024-03-11 Farnoosh Abdollahi, Mahshid Saghatchi, Amirhosein Paryab, Adrine Malek Khachatourian, Emma D. Stephens, Muhammet S. Toprak, Maryam Badv
Due to organ donor shortages, long transplant waitlists, and the complications/limitations associated with auto and allotransplantation, biomaterials and tissue-engineered models are gaining attention as feasible alternatives for replacing and reconstructing damaged organs and tissues. Among various tissue engineering applications, bone tissue engineering has become a promising strategy to replace
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Hydrogels with dual sensitivity to temperature and pH in physiologically relevant ranges as supports for versatile controlled cell detachment Biomater. Adv. (IF 7.9) Pub Date : 2024-03-08 Rubén García-Sobrino, Irene Ruiz-Blas, Carolina García, Helmut Reinecke, Carlos Elvira, Juan Rodríguez-Hernández, Enrique Martínez-Campos, Alberto Gallardo
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Material matters: Degradation products affect regenerating Schwann cells Biomater. Adv. (IF 7.9) Pub Date : 2024-03-08 Kendell M. Pawelec, Jeremy M.L. Hix, Erik M. Shapiro
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Naturally sourced amphiphilic peptides as paclitaxel vehicles for breast cancer treatment Biomater. Adv. (IF 7.9) Pub Date : 2024-03-05 Rongli Chen, Ergang Liu, Yuefei Fang, Nan Gao, Meng Zhang, Xiaoru Zhang, Wanying Chen, Chuxin Liang, Yu Zhang, Yongzhuo Huang
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Evaluating the photodynamic efficacy of nebulized curcumin-loaded liposomes prepared by thin-film hydration and dual centrifugation: In vitro and in ovo studies Biomater. Adv. (IF 7.9) Pub Date : 2024-03-04 Lena Bender, Abdallah M. Ayoub, Jan Schulze, Muhammad Umair Amin, Damiano Librizzi, Konrad H. Engelhardt, Valeri Roschenko, Behrooz H. Yousefi, Jens Schäfer, Eduard Preis, Udo Bakowsky
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In vitro development and optimization of cell-laden injectable bioprinted gelatin methacryloyl (GelMA) microgels mineralized on the nanoscale Biomater. Adv. (IF 7.9) Pub Date : 2024-03-02 Mauricio Gonçalves da Costa Sousa, Gabriela de Souza Balbinot, Ramesh Subbiah, Rahul Madathiparambil Visalakshan, Anthony Tahayeri, Maria Elisa Lima Verde, Avathamsa Athirasala, Genevieve Romanowicz, Robert E. Guldberg, Luiz E. Bertassoni
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Unlocking apoptosis in triple negative breast cancer: Harnessing “glutamine trap” to amplify the efficacy of lapatinib-loaded mixed micelles Biomater. Adv. (IF 7.9) Pub Date : 2024-03-02 Rohan Ghadi, Kaushik Kuche, Tushar Date, Bhargavi Nallamothu, Dasharath Chaudhari, Sanyog Jain
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Development of novel hybrid 3D-printed degradable artificial joints incorporating electrospun pharmaceutical- and growth factor-loaded nanofibers for small joint reconstruction Biomater. Adv. (IF 7.9) Pub Date : 2024-02-28 Yung-Heng Hsu, Ying-Chao Chou, Chao-Lin Chen, Yi-Hsun Yu, Chia-Jung Lu, Shih-Jung Liu
Small joint reconstruction remains challenging and can lead to prosthesis-related complications, mainly due to the suboptimal performance of the silicone materials used and adverse host reactions. In this study, we developed hybrid artificial joints using three-dimensional printing (3D printing) for polycaprolactone (PCL) and incorporated electrospun nanofibers loaded with drugs and biomolecules for
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Functional nanomaterials as photosensitizers or delivery systems for antibacterial photodynamic therapy Biomater. Adv. (IF 7.9) Pub Date : 2024-02-28 Ruijiao Yan, Meijun Zhan, Jingchen Xu, Qiang Peng
Bacterial infection is a global health problem that closely related to various diseases threatening human life. Although antibiotic therapy has been the mainstream treatment method for various bacterial infectious diseases for decades, the increasing emergence of bacterial drug resistance has brought enormous challenges to the application of antibiotics. Therefore, developing novel antibacterial strategies
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Hyaluronic acid-based hydrogels with tunable mechanics improved structural and contractile properties of cells Biomater. Adv. (IF 7.9) Pub Date : 2024-02-28 Šimon Klimovič, Deborah Beckerová, Jakub Věžník, Daniil Kabanov, Karel Lacina, Sarka Jelinkova, Jaromír Gumulec, Vladimír Rotrekl, Jan Přibyl
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Biodegradable and 3D printable lysine functionalized polycaprolactone scaffolds for tissue engineering applications Biomater. Adv. (IF 7.9) Pub Date : 2024-02-28 Sonali S. Naik, Arun Torris, Namita R. Choudhury, Naba K. Dutta, Kiran Sukumaran Nair
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Crown-ether threaded covalent organic polyrotaxane framework (COPF) towards synergistic crown/Zn2+/photothermal/photodynamic antibacterial and infected wound healing therapy Biomater. Adv. (IF 7.9) Pub Date : 2024-02-26 Shaoyu Wang, Jing Zhang, Lichao Chu, Hongquan Xiao, Changqing Miao, Zhengxuan Pan, Yanan Qiao, Zengyao Wang, Baolong Zhou
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In vivo assessment of marine vs bovine origin collagen-based composite scaffolds promoting bone regeneration in a New Zealand rabbit model Biomater. Adv. (IF 7.9) Pub Date : 2024-02-26 Gabriela S. Diogo, María Permuy, Catarina F. Marques, Cármen G. Sotelo, Ricardo I. Pérez-Martín, Julia Serra, Pio González, Fernando Munõz, Rogério P. Pirraco, Rui L. Reis, Tiago H. Silva
The ability of human tissues to self-repair is limited, which motivates the scientific community to explore new and better therapeutic approaches to tissue regeneration. The present manuscript provides a comparative study between a marine-based composite biomaterial, and another composed of well-established counterparts for bone tissue regeneration. Blue shark skin collagen was combined with bioapatite
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Ionized jet deposition of silver nanostructured coatings: Assessment of chemico-physical and biological behavior for application in orthopedics Biomater. Adv. (IF 7.9) Pub Date : 2024-02-25 Gabriela Graziani, Daniele Ghezzi, Marco Boi, Nicola Baldini, Enrico Sassoni, Martina Cappelletti, Giorgio Fedrizzi, Melania Maglio, Francesca Salamanna, Matilde Tschon, Lucia Martini, Stefano Zaffagnini, Milena Fini, Maria Sartori
Infection is one of the main issues connected to implantation of biomedical devices and represents a very difficult issue to tackle, for clinicians and for patients. This study aimed at tackling infection through antibacterial nanostructured silver coatings manufactured by Ionized Jet Deposition (IJD) for application as new and advanced coating systems for medical devices. Films composition and morphology
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Glutathione - IR 797 coupled Casein Nano-Trojan for augmenting the therapeutic efficacy of camptothecin in highly invasive triple negative breast cancer Biomater. Adv. (IF 7.9) Pub Date : 2024-02-23 Sajmina Khatun, Monika Pebam, Sri Amruthaa Sankaranarayanan, Sunil Venkanna Pogu, Veeresh Shetty Bantal, Aravind Kumar Rengan
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Enhancing neuroinduction activity of PLCL-based nerve conduits through native epineurium integration Biomater. Adv. (IF 7.9) Pub Date : 2024-02-23 Xiao Li, Xiaoyan Mao, Meihan Tao, Fang Liang, Xiaohong Tian, Jun Fan, Xiaohong Wang, Tianhao Yu, Qiang Ao
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3D-printed near-infrared-light-responsive on-demand drug-delivery scaffold for bone regeneration Biomater. Adv. (IF 7.9) Pub Date : 2024-02-22 Dong Qinyuan, Wan Zhuqing, Li Qing, Liu Yunsong, Zhang Ping, Zhang Xiao, Niu Yuting, Liu Hao, Zhou Yongsheng, Lv Longwei
Although several bioactive 3D-printed bone scaffolds loaded with multiple kinds of biomolecules for enhanced bone regeneration have been recently developed, the manipulation of on-demand release profiles of different biomolecules during bone regeneration remains challenging. Herein, a 3D-printed dual-drug-loaded biomimetic scaffold to regulate the host stem cell recruitment and osteogenic differentiation
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Towards bone regeneration: Understanding the nucleating ability of proline-rich peptides in biomineralisation Biomater. Adv. (IF 7.9) Pub Date : 2024-02-21 Øystein Øvrebø, Angela De Lauretis, Qianli Ma, Ståle Petter Lyngstadaas, Giuseppe Perale, Ola Nilsen, Filippo Rossi, Håvard J. Haugen
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Uncovering the relationship between macrophages and polypropylene surgical mesh Biomater. Adv. (IF 7.9) Pub Date : 2024-02-15 Nicholas T.H. Farr, Victoria L. Workman, Sanad Saad, Sabiniano Roman, Vanessa Hearnden, Christopher R. Chapple, Craig Murdoch, Cornelia Rodenburg, Sheila MacNeil
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Functionality of macrophages encapsulated in porcine decellularized adipose matrix hydrogels and interaction with Candida albicans Biomater. Adv. (IF 7.9) Pub Date : 2024-02-13 Mónica Cicuéndez, Andrea García-Lizarribar, Laura Casarrubios, María José Feito, Francisco Javier Fernández-San-Argimiro, Nerea García-Urkia, Olatz Murua, Iratxe Madarieta, Beatriz Olalde, Rosalía Diez-Orejas, María Teresa Portolés
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A versatile theranostic magnetic polydopamine iron oxide NIR laser-responsive nanosystem containing doxorubicin for chemo-photothermal therapy of melanoma Biomater. Adv. (IF 7.9) Pub Date : 2024-02-12 Mahvash Dehghankhold, Fatemeh Ahmadi, Navid Nezafat, Mehdi Abedi, Pooya Iranpour, Amirreza Dehghanian, Omid Koohi-Hosseinabadi, Amin Reza Akbarizadeh, Zahra Sobhani
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In vitro neuronal and glial response to magnetically stimulated piezoelectric poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV)/cobalt ferrite (CFO) microspheres Biomater. Adv. (IF 7.9) Pub Date : 2024-02-10 Tiffany S. Pinho, Jorge Ribeiro Cibrão, Deolinda Silva, Sandra Barata-Antunes, Jonas Campos, João L. Afonso, Belém Sampaio-Marques, Clarisse Ribeiro, André S. Macedo, Pedro Martins, Cristiana B. Cunha, Senentxu Lanceros-Mendez, António J. Salgado
Polymer biomaterials are being considered for tissue regeneration due to the possibility of resembling different extracellular matrix characteristics. However, most current scaffolds cannot respond to physical-chemical modifications of the cell microenvironment. Stimuli-responsive materials, such as electroactive smart polymers, are increasingly gaining attention once they can produce electrical potentials
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Dual cross-linked COL1/HAp bionic gradient scaffolds containing human amniotic mesenchymal stem cells promote rotator cuff tendon–bone interface healing Biomater. Adv. (IF 7.9) Pub Date : 2024-02-09 Xiaomei Dai, Meijuan Yuan, Yuxia Yang, Mengbo Dang, Jian Yang, Junli Shi, Dianwei Liu, Mingjun Li, Hang Yao, Wenyong Fei
The tendon-bone interface heals through scar tissue, while the lack of a natural interface gradient structure and collagen fibre alignment leads to the occurrence of retearing. Therefore, the promotion of tendon healing has become the focus of regenerative medicine. The purpose of this study was to develop a gradient COL1/ hydroxyapatite (HAp) biomaterial loaded with human amniotic mesenchymal stem
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Corrigendum to “Additive manufacturing of Ni-free Ti-based shape memory alloys: A review” [Biomater. Adv. Volume 158 (2024) 213774] Biomater. Adv. (IF 7.9) Pub Date : 2024-02-06 Tania Vilella, Daniel Rodríguez, Gemma Fargas
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Corrigendum to “Modification of the small intestinal submucosa membrane with oligopeptides screened from intrinsically disordered regions to promote angiogenesis and accelerate wound healing” [Biomater. Adv. 148 (2023) 213360] Biomater. Adv. (IF 7.9) Pub Date : 2024-02-06 Shiqing Ma, Yilin Yang, Yuzhu Mu, Huizhen Peng, Pengfei Wei, Wei Jing, Cheng Peng, Xiangning Liu, Bo Zhao, Mingxiang Cai, Zihao Liu, Xueqiao Yu, Jiayin Deng
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Engineered platelet-based immune engager for tumor post-surgery treatment Biomater. Adv. (IF 7.9) Pub Date : 2024-02-03 Mo Chen, Jinniu Zhang, Huangjuan Li, Yueyang Deng, Yun Huang, Wenhao Shen, Yixing Zeng, Tianyuan Ci
Tumor metastasis and recurrence are principal reasons for the high mortality and poor prognosis of cancers. Inefficient engagement between T cell and tumor cell, as well as the universal existence of immune checkpoints, are important factors to the limited immunological surveillance of the immune systems to tumor cells. Herein, an immune engager based on engineered platelets with CD3 antibody modification
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Mechanistic insights into the spontaneous induction of bone formation Biomater. Adv. (IF 7.9) Pub Date : 2024-02-02 Ugo Ripamonti, Raquel Duarte
The grand discovery of morphogens, or “”, revealed that tissue morphogenesis is initiated by soluble molecular signals or morphogens primarily belonging to the transforming growth factor-β (TGF-β) supergene family. The regenerative potential of bone rests on its extracellular matrix, which is the repository of several morphogens that tightly control cellular differentiating pathways, cellular matrix
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Thermal spray processes influencing surface chemistry and in-vitro hemocompatibility of hydroxyapatite-based orthopedic implants Biomater. Adv. (IF 7.9) Pub Date : 2024-01-28 Deep Shankar, K. Jayaganesh, Niranjan Gowda, K.S. Lakshmi, K.J. Jayanthi, Sudhakar C. Jambagi
Orthopedic implants made from titanium are a popular choice in the medical field because of their remarkable strength-to-weight ratio. Nevertheless, they may not interact well with human blood, resulting in thrombosis and hemolysis. In fact, non-hemocompatibility is believed to be responsible for about 31 % of medical device failures in the US alone, requiring painful and expensive revision surgery
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3D printed barium titanate/calcium silicate composite biological scaffold combined with structural and material properties Biomater. Adv. (IF 7.9) Pub Date : 2024-01-26 Junnan Wu, Chen Jiao, Hanjiao Yu, Syed Mesum Raza Naqvi, Mengxing Ge, Kunzhan Cai, Huixin Liang, Jing Liu, Jianfeng Zhao, Zongjun Tian, Dongsheng Wang, Lida Shen
In the case of a large bone defect, the human endogenous electrical field is no longer sufficient. Therefore, it is necessary to support structural electrical bone scaffolds. Barium titanate (BT) has received much attention in bone tissue engineering applications due to its biocompatibility and ability to maintain charged surfaces. However, its processability is poor and it does not have the biological
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Polydopamine based photothermal/photodynamic synchronous coating modified intraocular lens for efficient and safer posterior capsule opacification prevention Biomater. Adv. (IF 7.9) Pub Date : 2024-01-24 Qiuna Fang, Chen Qin, Lan Duo, Fan Fei, Qingqing Jia, Hao Chen, Quankui Lin
Posterior capsule opacification (PCO), as one of the most common late complications after intraocular lens (IOL) implantation in cataract surgery, seriously affects patients' postoperative vision and surgical satisfaction, and can only be treated by laser incision of the posterior capsule. Although drug eluting coating modification have been proved to inhibit PCO effectively, the complicated coating
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In vitro cytotoxicity of magnetic-fluorescent bioactive glasses on SaOS-2, MC3T3-E1, BJ fibroblast cells, their hemolytic activity, and sorafenib release behavior Biomater. Adv. (IF 7.9) Pub Date : 2024-01-24 Aylin M. Deliormanlı, Begüm Rahman, Harika Atmaca
In the study, the fabrication of superparamagnetic-fluorescent bioactive glasses in the form of the particle, nanofiber, and 3D scaffolds was performed by including maghemite (γ-FeO) nanoparticles and photoluminescent rare earth element ions (Eu, Gd, and Yb) using sol-gel, electrospinning, and robocasting techniques, respectively. The cytotoxicity of the magnetic-fluorescent bioactive glasses on osteosarcoma
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Mechanical, bioactive, and long-lasting antibacterial properties of a Ti scaffold with gradient pores releasing iodine ions Biomater. Adv. (IF 7.9) Pub Date : 2024-01-24 Mahmoud Gallab, Phuc Thi Minh Le, Seine A. Shintani, Hiroaki Takadama, Morihiro Ito, Hisashi Kitagaki, Tomiharu Matsushita, Shintaro Honda, Yaichiro Okuzu, Shunsuke Fujibayashi, Seiji Yamaguchi
The ideal bone implant would effectively prevent aseptic as well as septic loosening by minimizing stress shielding, maximizing bone ingrowth, and preventing implant-associated infections. Here, a novel gradient-pore-size titanium scaffold was designed and manufactured to address these requirements. The scaffold features a larger pore size (900 μm) on the top surface, gradually decreasing to small
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A sustainable strategy for generating highly stable human skin equivalents based on fish collagen Biomater. Adv. (IF 7.9) Pub Date : 2024-01-24 Shi Hua Tan, Shaoqiong Liu, Swee Hin Teoh, Carine Bonnard, David Leavesley, Kun Liang
Tissue engineered skin equivalents are increasingly recognized as potential alternatives to traditional skin models such as human skin or animal skin models. However, most of the currently investigated human skin equivalents (HSEs) are constructed using mammalian collagen which can be expensive and difficult to extract. Fish skin is a waste product produced by fish processing industries and identified
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Hybrid gelatin-ascorbyl phosphate scaffolds accelerate diabetic wound healing via ROS scavenging, angiogenesis and collagen remodeling Biomater. Adv. (IF 7.9) Pub Date : 2024-01-21 Zhen Zhang, Chunlin Huang, Shiyao Guan, Liying Wang, Hanxiao Yin, Junqiang Yin, Jie Liu, Jun Wu
Skin wound healing, particularly diabetic wound healing, is challenging in clinical management. Impaired wound healing is associated with persistent oxidative stress, altered inflammatory responses, unsatisfactory angiogenesis and epithelialization. Magnesium ascorbyl phosphate (MAP), which is an ascorbic acid derivative and active ingredient in cosmetics, has been reported to scavenge , and is considered
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Gold nanoparticles decorated on MOF derived Cu5Zn8 hollow porous carbon nanocubes for magnetic resonance imaging guided tumor microenvironment-mediated synergistic chemodynamic and photothermal therapy Biomater. Adv. (IF 7.9) Pub Date : 2024-01-20 Senthilkumar Thirumurugan, Pranjyan Dash, Rajalakshmi Sakthivel, Yu-Chien Lin, Ying-Sui Sun, Ching-Po Lin, An-Ni Wang, Xinke Liu, Udesh Dhawan, Ren-Jei Chung
Combining chemodynamic therapy (CDT) with photothermal therapy (PTT) has developed as a promising approach for cancer treatment, as it enhances therapeutic efficiency through redox reactions and external laser induction. In this study, we designed metal organic framework (MOF) -derived CuZn/HPCNC through a carbonization process and decorated them with gold nanoparticles (Au@CuZn/HPCNC). The resulting
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Lab on chip based self-adjustable liposomes for rapid wound healing: An in depth in vitro, in vivo and higher dose toxicity investigation Biomater. Adv. (IF 7.9) Pub Date : 2024-01-19 Rahul Maheshwari, Piyush Ghode, Mayank Sharma
Thanks to microfluidic technology, different nano-delivery systems are becoming clinically viable. Using a novel and rapid microfluidic hydrodynamic focusing (MHF) method (lipids on chip) we developed self-adaptable liposomes (SLs) containing cefpodoxime proxetil (CP) for the treatment of skin infections caused by . SLs were optimized using different flow rate ratios in the MHF method and the final
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Zwitterion mediated anti-protein adsorption on polypropylene mesh to reduce inflammation for efficient hernia repair Biomater. Adv. (IF 7.9) Pub Date : 2024-01-19 Ying Mao, Qian Wang, Huiru Zhang, Yan Li, Lu Wang
The effectiveness of polypropylene (PP) mesh is often compromised by severe inflammation. Engineering anti-inflammatory coatings has significant implications for PP mesh to repair unwanted hernias. Here, we presented a facile strategy to develop an anti-fouling coating consisting of zwitterionic poly(carboxybetaine methacrylate) (PCBMA), which could prohibit protein adsorption to endow PP mesh with
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CD44 targeted-chondroitin sulfate nanoparticles: Fine-tuning hydrophobic groups to enhance in vitro pH-responsiveness and in vivo efficacy for advanced breast cancer treatment Biomater. Adv. (IF 7.9) Pub Date : 2024-01-18 Nayereh Azimijou, Reza Karimi-Soflou, Akbar Karkhaneh
The design of tumor-targeting nanoparticles with precisely controlled physical-biological properties may improve the delivery of chemotherapeutic agents. This study introduces pH-sensitive chondroitin sulfate-cholesterol (ChS-Chol) nano-assemblies for targeted intracellular doxorubicin (Dox) delivery in breast cancer treatment. Various ChS-Chol copolymers were synthesized, yielding self-assembling
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Optimizing the fabrication of electrospun nanofibers of prochlorperazine for enhanced dissolution and permeation properties Biomater. Adv. (IF 7.9) Pub Date : 2024-01-18 Hasham Shafi, D.V. Siva Reddy, Rumaisa Rashid, Trisha Roy, Shabnam Kawoosa, G.N. Bader, Chakradhar JVUS, Abdalla Abdal-hay, Mushtaq A. Beigh, Shafquat Majeed, Nisar Ahmad Khan, Faheem A. Sheikh
Despite being an approved antiemetic for more than five decades, the clinical usefulness of prochlorperazine is limited by its low solubility and inconsistent absorption in the gastrointestinal tract, which presents challenges for nanotherapeutic interventions. Here, we report the preparation of a highly soluble and permeable nanofiber formulation of prochlorperazine using the Quality-by-Design approach
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Biomaterial engineering for cell transplantation Biomater. Adv. (IF 7.9) Pub Date : 2024-01-17 Amirmasoud Samadi, Ali Moammeri, Shamim Azimi, Bexi M. Bustillo-Perez, M. Rezaa Mohammadi
The current paradigm of medicine is mostly designed to block or prevent pathological events. Once the disease-led tissue damage occurs, the limited endogenous regeneration may lead to depletion or loss of function for cells in the tissues. Cell therapy is rapidly evolving and influencing the field of medicine, where in some instances attempts to address cell loss in the body. Due to their biological