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How a spreadsheet helped me to land my dream job Nature (IF 64.8) Pub Date : 2024-03-28
A shared spreadsheet, passed from generation to generation, helps graduate students in management navigate the academic job market. Whatever your field of study, you can make one, too.
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Video: Cancer-busting vaccines Nature (IF 64.8) Pub Date : 2024-03-27
Treatments that could train the immune system to identify and destroy cancer cells are on the way.
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No sweat: Moisture-wicking device keeps wearable-tech dry Nature (IF 64.8) Pub Date : 2024-03-27
Breathable patch could allow for comfortable and multifunctional wearable electronics.
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CGRP sensory neurons promote tissue healing via neutrophils and macrophages Nature (IF 64.8) Pub Date : 2024-03-27 Yen-Zhen Lu, Bhavana Nayer, Shailendra Kumar Singh, Yasmin K. Alshoubaki, Elle Yuan, Anthony J. Park, Kenta Maruyama, Shizuo Akira, Mikaël M. Martino
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Formation of memory assemblies through the DNA-sensing TLR9 pathway Nature (IF 64.8) Pub Date : 2024-03-27 Vladimir Jovasevic, Elizabeth M. Wood, Ana Cicvaric, Hui Zhang, Zorica Petrovic, Anna Carboncino, Kendra K. Parker, Thomas E. Bassett, Maria Moltesen, Naoki Yamawaki, Hande Login, Joanna Kalucka, Farahnaz Sananbenesi, Xusheng Zhang, Andre Fischer, Jelena Radulovic
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Five million years of Antarctic Circumpolar Current strength variability Nature (IF 64.8) Pub Date : 2024-03-27 Frank Lamy, Gisela Winckler, Helge W. Arz, Jesse R. Farmer, Julia Gottschalk, Lester Lembke-Jene, Jennifer L. Middleton, Michèlle van der Does, Ralf Tiedemann, Carlos Alvarez Zarikian, Chandranath Basak, Anieke Brombacher, Levin Dumm, Oliver M. Esper, Lisa C. Herbert, Shinya Iwasaki, Gaston Kreps, Vera J. Lawson, Li Lo, Elisa Malinverno, Alfredo Martinez-Garcia, Elisabeth Michel, Simone Moretti, Christopher
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Optomechanical realization of the bosonic Kitaev chain Nature (IF 64.8) Pub Date : 2024-03-27 Jesse J. Slim, Clara C. Wanjura, Matteo Brunelli, Javier del Pino, Andreas Nunnenkamp, Ewold Verhagen
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TRBC1-targeting antibody–drug conjugates for the treatment of T cell cancers Nature (IF 64.8) Pub Date : 2024-03-27 Tushar D. Nichakawade, Jiaxin Ge, Brian J. Mog, Bum Seok Lee, Alexander H. Pearlman, Michael S. Hwang, Sarah R. DiNapoli, Nicolas Wyhs, Nikita Marcou, Stephanie Glavaris, Maximilian F. Konig, Sandra B. Gabelli, Evangeline Watson, Cole Sterling, Nina Wagner-Johnston, Sima Rozati, Lode Swinnen, Ephraim Fuchs, Drew M. Pardoll, Kathy Gabrielson, Nickolas Papadopoulos, Chetan Bettegowda, Kenneth W. Kinzler
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Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity Nature (IF 64.8) Pub Date : 2024-03-27 Jason B. Ross, Lara M. Myers, Joseph J. Noh, Madison M. Collins, Aaron B. Carmody, Ronald J. Messer, Erica Dhuey, Kim J. Hasenkrug, Irving L. Weissman
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Structural basis of exoribonuclease-mediated mRNA transcription termination Nature (IF 64.8) Pub Date : 2024-03-27 Yuan Zeng, Hong-Wei Zhang, Xiao-Xian Wu, Yu Zhang
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High-fidelity spin qubit operation and algorithmic initialization above 1 K Nature (IF 64.8) Pub Date : 2024-03-27 Jonathan Y. Huang, Rocky Y. Su, Wee Han Lim, MengKe Feng, Barnaby van Straaten, Brandon Severin, Will Gilbert, Nard Dumoulin Stuyck, Tuomo Tanttu, Santiago Serrano, Jesus D. Cifuentes, Ingvild Hansen, Amanda E. Seedhouse, Ensar Vahapoglu, Ross C. C. Leon, Nikolay V. Abrosimov, Hans-Joachim Pohl, Michael L. W. Thewalt, Fay E. Hudson, Christopher C. Escott, Natalia Ares, Stephen D. Bartlett, Andrea Morello
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Controlling the helicity of light by electrical magnetization switching Nature (IF 64.8) Pub Date : 2024-03-27 Pambiang Abel Dainone, Nicholas Figueiredo Prestes, Pierre Renucci, Alexandre Bouché, Martina Morassi, Xavier Devaux, Markus Lindemann, Jean-Marie George, Henri Jaffrès, Aristide Lemaitre, Bo Xu, Mathieu Stoffel, Tongxin Chen, Laurent Lombez, Delphine Lagarde, Guangwei Cong, Tianyi Ma, Philippe Pigeat, Michel Vergnat, Hervé Rinnert, Xavier Marie, Xiufeng Han, Stephane Mangin, Juan-Carlos Rojas-Sánchez
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Graphene nanoribbons grown in hBN stacks for high-performance electronics Nature (IF 64.8) Pub Date : 2024-03-27 Bosai Lyu, Jiajun Chen, Sen Wang, Shuo Lou, Peiyue Shen, Jingxu Xie, Lu Qiu, Izaac Mitchell, Can Li, Cheng Hu, Xianliang Zhou, Kenji Watanabe, Takashi Taniguchi, Xiaoqun Wang, Jinfeng Jia, Qi Liang, Guorui Chen, Tingxin Li, Shiyong Wang, Wengen Ouyang, Oded Hod, Feng Ding, Michael Urbakh, Zhiwen Shi
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A figure of merit for efficiency roll-off in TADF-based organic LEDs Nature (IF 64.8) Pub Date : 2024-03-27 S. Diesing, L. Zhang, E. Zysman-Colman, I. D. W. Samuel
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The complex polyploid genome architecture of sugarcane Nature (IF 64.8) Pub Date : 2024-03-27 A. L. Healey, O. Garsmeur, J. T. Lovell, S. Shengquiang, A. Sreedasyam, J. Jenkins, C. B. Plott, N. Piperidis, N. Pompidor, V. Llaca, C. J. Metcalfe, J. Doležel, P. Cápal, J. W. Carlson, J. Y. Hoarau, C. Hervouet, C. Zini, A. Dievart, A. Lipzen, M. Williams, L. B. Boston, J. Webber, K. Keymanesh, S. Tejomurthula, S. Rajasekar, R. Suchecki, A. Furtado, G. May, P. Parakkal, B. A. Simmons, K. Barry, R
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Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF Nature (IF 64.8) Pub Date : 2024-03-27 Sandi Radko-Juettner, Hong Yue, Jacquelyn A. Myers, Raymond D. Carter, Alexis N. Robertson, Priya Mittal, Zhexin Zhu, Baranda S. Hansen, Katherine A. Donovan, Moritz Hunkeler, Wojciech Rosikiewicz, Zhiping Wu, Meghan G. McReynolds, Shourya S. Roy Burman, Anna M. Schmoker, Nada Mageed, Scott A. Brown, Robert J. Mobley, Janet F. Partridge, Elizabeth A. Stewart, Shondra M. Pruett-Miller, Behnam Nabet
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Climate velocities and species tracking in global mountain regions Nature (IF 64.8) Pub Date : 2024-03-27 Wei-Ping Chan, Jonathan Lenoir, Guan-Shuo Mai, Hung-Chi Kuo, I-Ching Chen, Sheng-Feng Shen
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Revealing uncertainty in the status of biodiversity change Nature (IF 64.8) Pub Date : 2024-03-27 T. F. Johnson, A. P. Beckerman, D. Z. Childs, T. J. Webb, K. L. Evans, C. A. Griffiths, P. Capdevila, C. F. Clements, M. Besson, R. D. Gregory, G. H. Thomas, E. Delmas, R. P. Freckleton
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The complex circumstellar environment of supernova 2023ixf Nature (IF 64.8) Pub Date : 2024-03-27 E. A. Zimmerman, I. Irani, P. Chen, A. Gal-Yam, S. Schulze, D. A. Perley, J. Sollerman, A. V. Filippenko, T. Shenar, O. Yaron, S. Shahaf, R. J. Bruch, E. O. Ofek, A. De Cia, T. G. Brink, Y. Yang, S. S. Vasylyev, S. Ben Ami, M. Aubert, A. Badash, J. S. Bloom, P. J. Brown, K. De, G. Dimitriadis, C. Fransson, C. Fremling, K. Hinds, A. Horesh, J. P. Johansson, M. M. Kasliwal, S. R. Kulkarni, D. Kushnir
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Single-cell multiplex chromatin and RNA interactions in ageing human brain Nature (IF 64.8) Pub Date : 2024-03-27 Xingzhao Wen, Zhifei Luo, Wenxin Zhao, Riccardo Calandrelli, Tri C. Nguyen, Xueyi Wan, John Lalith Charles Richard, Sheng Zhong
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A three-dimensional liquid diode for soft, integrated permeable electronics Nature (IF 64.8) Pub Date : 2024-03-27 Binbin Zhang, Jiyu Li, Jingkun Zhou, Lung Chow, Guangyao Zhao, Ya Huang, Zhiqiang Ma, Qiang Zhang, Yawen Yang, Chun Ki Yiu, Jian Li, Fengjun Chun, Xingcan Huang, Yuyu Gao, Pengcheng Wu, Shengxin Jia, Hu Li, Dengfeng Li, Yiming Liu, Kuanming Yao, Rui Shi, Zhenlin Chen, Bee Luan Khoo, Weiqing Yang, Feng Wang, Zijian Zheng, Zuankai Wang, Xinge Yu
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Interchain-expanded extra-large-pore zeolites Nature (IF 64.8) Pub Date : 2024-03-27 Zihao Rei Gao, Huajian Yu, Fei-Jian Chen, Alvaro Mayoral, Zijian Niu, Ziwen Niu, Xintong Li, Hua Deng, Carlos Márquez-Álvarez, Hong He, Shutao Xu, Yida Zhou, Jun Xu, Hao Xu, Wei Fan, Salvador R. G. Balestra, Chao Ma, Jiazheng Hao, Jian Li, Peng Wu, Jihong Yu, Miguel A. Camblor
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Evidence for chiral graviton modes in fractional quantum Hall liquids Nature (IF 64.8) Pub Date : 2024-03-27 Jiehui Liang, Ziyu Liu, Zihao Yang, Yuelei Huang, Ursula Wurstbauer, Cory R. Dean, Ken W. West, Loren N. Pfeiffer, Lingjie Du, Aron Pinczuk
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High-threshold and low-overhead fault-tolerant quantum memory Nature (IF 64.8) Pub Date : 2024-03-27 Sergey Bravyi, Andrew W. Cross, Jay M. Gambetta, Dmitri Maslov, Patrick Rall, Theodore J. Yoder
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A brainstem–hypothalamus neuronal circuit reduces feeding upon heat exposure Nature (IF 64.8) Pub Date : 2024-03-27 Marco Benevento, Alán Alpár, Anna Gundacker, Leila Afjehi, Kira Balueva, Zsofia Hevesi, János Hanics, Sabah Rehman, Daniela D. Pollak, Gert Lubec, Peer Wulff, Vincent Prevot, Tamas L. Horvath, Tibor Harkany
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Thermonuclear explosions on neutron stars reveal the speed of their jets Nature (IF 64.8) Pub Date : 2024-03-27 Thomas D. Russell, Nathalie Degenaar, Jakob van den Eijnden, Thomas Maccarone, Alexandra J. Tetarenko, Celia Sánchez-Fernández, James C. A. Miller-Jones, Erik Kuulkers, Melania Del Santo
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Daily briefing: Tweeting about your paper doesn’t boost citations Nature (IF 64.8) Pub Date : 2024-03-27
Posting about a paper on X seems to boost engagement but not citations. Plus, researchers pinpoint humans’ first home outside Africa and what the science says about the Baltimore bridge collapse.
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The real time-travel paradox was the friends we made along the way Nature (IF 64.8) Pub Date : 2024-03-27
Life at the cutting edge.
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Climate change has slowed Earth’s rotation — and could affect how we keep time Nature (IF 64.8) Pub Date : 2024-03-27
The effect of melting polar ice could delay the need for a ‘leap second’ by three years.
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Divisive Sun-dimming study at Harvard cancelled: what’s next? Nature (IF 64.8) Pub Date : 2024-03-27
As the climate crisis rages on, advocacy for testing controversial solar geoengineering technology is ramping up.
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The surprising history of the Southern Ocean’s super current Nature (IF 64.8) Pub Date : 2024-03-27 Natalie J. Burls
Reconstructions of the strength of the Antarctic circumpolar current.
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Anti-ageing antibodies revive the immune system Nature (IF 64.8) Pub Date : 2024-03-27 Yasar Arfat T. Kasu, Robert A. J. Signer
Rejuvenating an aged immune system with antibody therapy.
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Maple-scented cacti and pom-pom cats: how pranking at work can lift lab spirits Nature (IF 64.8) Pub Date : 2024-03-27
Whether for April Fools’ Day or year-round, practical jokes allow scientists to tap into creative thinking while building group camaraderie.
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In This Issue Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-03-26
Proceedings of the National Academy of Sciences, Volume 121, Issue 13, March 2024.
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Legume seed system performance in sub-Saharan Africa: barriers, opportunities, and scaling options. A review Agron. Sustain. Dev. (IF 7.3) Pub Date : 2024-03-26 Caitlin Breen, Noel Ndlovu, Peter C. McKeown, Charles Spillane
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How farmer preferences and climate change beliefs shape BMP adoption Agric. Syst. (IF 6.6) Pub Date : 2024-03-28 Sarah Van Wyngaarden, Sven Anders, Debra Davidson
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The propensity for covalent organic frameworks to template polymer entanglement Science (IF 56.9) Pub Date : 2024-03-22 S. Ephraim Neumann, Junpyo Kwon, Cornelius Gropp, Le Ma, Raynald Giovine, Tianqiong Ma, Nikita Hanikel, Kaiyu Wang, Tiffany Chen, Shaan Jagani, Robert O. Ritchie, Ting Xu, Omar M. Yaghi
The introduction of molecularly woven three-dimensional (3D) covalent organic framework (COF) crystals into polymers of varying types invokes different forms of contact between filler and polymer. Whereas the combination of woven COFs with amorphous and brittle polymethyl methacrylate results in surface interactions, the use of the liquid-crystalline polymer polyimide induces the formation of polymer-COF
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Tweeting your research paper boosts engagement but not citations Nature (IF 64.8) Pub Date : 2024-03-27
Analysis of a random selection of papers shared on social media showed no causative link between posting and citations.
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Cancer-vaccine trials give reasons for optimism Nature (IF 64.8) Pub Date : 2024-03-27
Therapeutic vaccines could provide a transformative shot in the arm for cancer treatment.
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Journal editors are resigning en masse: what do these group exits achieve? Nature (IF 64.8) Pub Date : 2024-03-27
Editorial rebellions seem to be on the rise, as researchers seek more control over scholarly communication.
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How does a cancer vaccine work? Nature (IF 64.8) Pub Date : 2024-03-27
After decades of slow progress, therapeutic vaccines that direct the immune system to attack tumours could soon become a fixture of cancer treatment.
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These levitating bubbles are long-lived and puncture-proof Nature (IF 64.8) Pub Date : 2024-03-26
Soap bubbles bombarded with ultrasonic waves rise into mid-air and can survive being stabbed with a needle.
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Daily briefing: Weird new electron behaviour thrills physicists Nature (IF 64.8) Pub Date : 2024-03-26
The first experiments have shown that electrons can behave as if they had fractional charges. Plus, how birds gesture ‘after you’ to their mate and the real story of how the Big Bang got its name.
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The beauty of what science can do when urgently needed Nature (IF 64.8) Pub Date : 2024-03-26
Working amid New York City’s pandemic response inspired Nili Ostrov’s approach to expanding the list of organisms that can be used in synthetic biology and engineering.
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Abortion-pill challenge provokes doubt from US Supreme Court Nature (IF 64.8) Pub Date : 2024-03-26
Lawsuit could roll back access to mifepristone, a drug widely used to induce abortion in the United States.
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A delay that makes wireless communication faster Nature (IF 64.8) Pub Date : 2024-03-26
A 3D waveguide on a chip adds delays to multifrequency telecommunication signals so they all arrive at the same time, undistorted.
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Daily briefing: Pregnancy advances your ‘biological’ age’ Nature (IF 64.8) Pub Date : 2024-03-25
Being pregnant can increase a person’s ‘biological age’ by a couple of years — but giving birth reverses these changes. Plus, urban vegetable gardens have a shocking carbon footprint.
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Daily briefing: How PhD assessment needs to change Nature (IF 64.8) Pub Date : 2024-03-22
What Briefing readers think about how doctoral degrees should be evaluated. Plus, the X-factor in bird song that makes males irresistible and why like-charged particles can sometimes attract.
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Reaction amplification with a gain: Triplet exciton–mediated quantum chain using mixed crystals with a tailor-made triplet sensitizer Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-03-27 Indrajit Paul, Krzysztof A. Konieczny, Roberto Chavez, Miguel A. Garcia-Garibay
Photochemical valence bond isomerization of a crystalline Dewar benzene ( DB ) diacid monoanion salt with an acetophenone-linked piperazinium cation that serves as an intramolecular triplet energy sensitizer ( DB-AcPh-Pz ) exhibits a quantum chain reaction with as many as 450 product molecules per photon absorbed (Φ ≈ 450). By contrast, isomorphous crystals of the DB diacid monosalt of an ethylbenzene-linked
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Defining T cell receptor repertoires using nanovial-based binding and functional screening Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-03-27 Doyeon Koo, Zhiyuan Mao, Robert Dimatteo, Miyako Noguchi, Natalie Tsubamoto, Jami McLaughlin, Wendy Tran, Sohyung Lee, Donghui Cheng, Joseph de Rutte, Giselle Burton Sojo, Owen N. Witte, Dino Di Carlo
The ability to selectively bind to antigenic peptides and secrete effector molecules can define rare and low-affinity populations of cells with therapeutic potential in emerging T cell receptor (TCR) immunotherapies. We leverage cavity-containing hydrogel microparticles, called nanovials, each coated with peptide-major histocompatibility complex (pMHC) monomers to isolate antigen-reactive T cells.
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Maintenance of persistent transmission of a plant arbovirus in its insect vector mediated by the Toll-Dorsal immune pathway Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-03-27 Yu-Juan He, Gang Lu, Bo-Jie Xu, Qian-Zhuo Mao, Yu-Hua Qi, Gao-Yang Jiao, Hai-Tao Weng, Yan-Zhen Tian, Hai-Jian Huang, Chuan-Xi Zhang, Jian-Ping Chen, Jun-Min Li
Throughout evolution, arboviruses have developed various strategies to counteract the host’s innate immune defenses to maintain persistent transmission. Recent studies have shown that, in addition to bacteria and fungi, the innate Toll-Dorsal immune system also plays an essential role in preventing viral infections in invertebrates. However, whether the classical Toll immune pathway is involved in
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Structural and electronic transformations of GeSe 2 glass under high pressures studied by X-ray absorption spectroscopy Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-03-27 Emin Mijit, Murat Durandurdu, João Elias F. S. Rodrigues, Angela Trapananti, S. Javad Rezvani, Angelika Dorothea Rosa, Olivier Mathon, Tetsuo Irifune, Andrea Di Cicco
Pressure-induced transformations in an archetypal chalcogenide glass (GeSe 2 ) have been investigated up to 157 GPa by X-ray absorption spectroscopy (XAS) and molecular dynamics (MD) simulations. Ge and Se K-edge XAS data allowed simultaneous tracking of the correlated local structural and electronic changes at both Ge and Se sites. Thanks to the simultaneous analysis of extended X-ray absorption fine
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Multi-axis fields boost SABRE hyperpolarization Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-03-27 Jacob R. Lindale, Loren L. Smith, Mathew W. Mammen, Shannon L. Eriksson, Lucas M. Everhart, Warren S. Warren
The inherently low signal-to-noise ratio of NMR and MRI is now being addressed by hyperpolarization methods. For example, iridium-based catalysts that reversibly bind both parahydrogen and ligands in solution can hyperpolarize protons (SABRE) or heteronuclei (X-SABRE) on a wide variety of ligands, using a complex interplay of spin dynamics and chemical exchange processes, with common signal enhancements
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Needs for a conceptual bridge between biological domestication and early food globalization Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-03-27 Xinyi Liu, Martin Jones
The past 15 y has seen much development in documentation of domestication of plants and animals as gradual traditions spanning millennia. There has also been considerable momentum in understanding the dispersals of major domesticated taxa across continents spanning thousands of miles. The two processes are often considered within different theoretical strains. What is missing from our repertoire of
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Causal functional maps of brain rhythms in working memory Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-03-27 Miles Wischnewski, Taylor A. Berger, Alexander Opitz, Ivan Alekseichuk
Human working memory is a key cognitive process that engages multiple functional anatomical nodes across the brain. Despite a plethora of correlative neuroimaging evidence regarding the working memory architecture, our understanding of critical hubs causally controlling overall performance is incomplete. Causal interpretation requires cognitive testing following safe, temporal, and controllable neuromodulation
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RCHY1 and OPTN are required for melanophagy, selective autophagy of melanosomes Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-03-27 Ki Won Lee, Ki-jun Ryu, Minju Kim, Seyeon Lim, Jisu Kim, Jeong Yoon Kim, Cheol Hwangbo, Jiyun Yoo, Yong-Yeon Cho, Kwang Dong Kim
Melanosomes are specific organelles dedicated to melanin synthesis and accumulation in melanocytes. Autophagy is suggestively involved in melanosome degradation, although the potential underlying molecular mechanisms remain elusive. In selective autophagy, autophagy receptors and E3-ligases are the key factors conferring cargo selectivity. In B16F10 cells, β-mangostin efficiently induced melanosome
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Elasticity and rheology of auxetic granular metamaterials Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-03-27 Daan Haver, Daniel Acuña, Shahram Janbaz, Edan Lerner, Gustavo Düring, Corentin Coulais
The flowing, jamming, and avalanche behavior of granular materials is satisfyingly universal and vexingly hard to tune: A granular flow is typically intermittent and will irremediably jam if too confined. Here, we show that granular metamaterials made from particles with a negative Poisson’s ratio yield more easily and flow more smoothly than ordinary granular materials. We first create a collection
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Trimethylamine-N-oxide depletes urea in a peptide solvation shell Proc. Natl. Acad. Sci. U.S.A. (IF 11.1) Pub Date : 2024-03-27 Mazin Nasralla, Harrison Laurent, Oliver L. G. Alderman, Thomas F. Headen, Lorna Dougan
Trimethylamine-N-oxide (TMAO) and urea are metabolites that are used by some marine animals to maintain their cell volume in a saline environment. Urea is a well-known denaturant, and TMAO is a protective osmolyte that counteracts urea-induced protein denaturation. TMAO also has a general protein-protective effect, for example, it counters pressure-induced protein denaturation in deep-sea fish. These
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Modelling the effects of potential climate change on the dynamics of multi-species mountain pastures: A case study in Gran Paradiso National Park, Italy Agric. Syst. (IF 6.6) Pub Date : 2024-03-27 S. Morgese, F. Casale, E. Movedi, R. Confalonieri, D. Bocchiola
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Developing causal loop diagrams for the perusal of soil health in agricultural practices – A case study of rice nursery cultivation practices in India Agric. Syst. (IF 6.6) Pub Date : 2024-03-27 Shraddha Vekhande, Bakul Rao