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Leptin receptor Gln223Arg and Lys109Arg polymorphisms may be associated with HBV‐related hepatocellular carcinoma risk: A system review and meta‐analysis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-18 Xiaofeng Dong, Mengjie Zou, Chunxing Li, Honglin Luo, Shaoliang Zhu, Zheng Gong
Increasing evidence has suggested a strong association of hepatocellular carcinoma (HCC) susceptibility and Gln223Arg (rs1137101) and Lys109Arg (rs1137100) polymorphisms in leptin receptor (LEPR) genes. To provide a quantitative assessment for such correlation, we reviewed all related systems and conducted meta‐analysis for case and control researches. A literature search of Web of Science, EMBASE
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Critical role of endoplasmic reticulum stress on bisphenol A‐induced cytotoxicity in human keratinocyte HaCaT cells Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-17 Sou Hyun Kim, Dong Wan Kang, Doyoung Kwon, Young‐Suk Jung
Bisphenol A (BPA) is widely used in plastic and paper products, and its exposure can occur through skin contact or oral ingestion. The hazardous effects of BPA absorbed through the skin may be more severe; however, few studies have investigated the skin toxicity of BPA. This study investigated the effects of BPA on human epidermal keratinocyte cell lines, which is relevant for skin exposure. BPA treatment
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Deciphering the prognostic landscape of osteosarcoma: Integrating the roles of hippo pathway genes, programmed cell death, and the tumor immune microenvironment Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-16 Huayan Ma, Yuxian Zhang, Jing Li, Tiantian Xie, Zhi Zhao
Osteosarcoma is a highly aggressive cancer prevalent among adolescents and young adults, notorious for its tendency to metastasize to the lungs. This research delves into the molecular foundations of osteosarcoma by examining the role of the Hippo signaling pathway and its interaction with the tumor immune microenvironment (TME). Through analysis of transcriptomic data from the TARGET‐OS dataset and
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Single‐cell and bulk RNA‐sequencing reveal SPP1 and CXCL12 as cell‐to‐cell communication markers to predict prognosis in lung adenocarcinoma Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-16 Zengtuan Xiao, Zhe Nian, Mengzhe Zhang, Zuo Liu, Pengpeng Zhang, Zhenfa Zhang
Lung adenocarcinoma (LUAD) generally presents as an immunosuppressive microenvironment. The characteristics of cell‐to‐cell communication in the LUAD microenvironment has been unclear. In this study, the LUAD bulk RNA‐seq data and single‐cell RNA‐seq data were retrieved from public dataset. Differential expression genes (DEGs) between LUAD tumor and adjacent non‐tumor tissues were calculated by limma
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Teaghrelin protected dopaminergic neurons in MPTP‐induced Parkinson's disease animal model by promoting PINK1/Parkin‐mediated mitophagy and AMPK/SIRT1/PGC1‐α‐mediated mitochondrial biogenesis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-16 Cian‐Fen Jhuo, Chun‐Jung Chen, Jason T.C. Tzen, Wen‐Ying Chen
Mitochondrial dysfunction, a common cellular hallmark in both familial and sporadic forms of Parkinson's disease (PD), is assumed to play a significant role in pathologic development and progression of the disease. Teaghrelin, a unique bioactive compound in some oolong tea varieties, has been demonstrated to protect SH‐SY5Y cells against 1‐methyl‐4‐phenylpyridinium induced neurotoxicity by binding
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Deciphering programmed cell death mechanisms in osteosarcoma for prognostic modeling Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-16 Jingyang Chen, Tengdi Fan, Lingxiao Pan, Hanshi Yang
Osteosarcoma (OS), known for its high recurrence and metastasis rates, poses a significant challenge in oncology. Our research investigates the role of programmed cell death (PCD) genes in OS and develops a prognostic model using advanced bioinformatics. We analyzed single‐cell sequencing data from the Gene Expression Omnibus (GEO) database to identify subpopulations, distinguish malignant from non‐malignant
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Comprehensive analysis of lung adenocarcinoma: Unveiling differential gene expression, survival‐linked genes, subtype stratification, and immune landscape implications Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-15 Yong Xi, Liu Xi, Jian Tan, Chaoqun Yu, Weiyu Shen, Bentong Yu
This study offers a detailed exploration of lung adenocarcinoma (LUAD), addressing its heterogeneity and treatment challenges through a multi‐faceted analysis that includes gene expression, genetic subtyping, pathway analysis, immune assessment, and drug sensitivity. It identifies 165 genes with significant expression differences and 46 genes associated with survival, revealing insights into oxidative
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Nephroprotective effects of coriander (Coriandrum sativum) leaves aqueous extracts in aristolochic acid‐intoxicated zebrafish embryos Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-13 Jen‐Ning Tsai, Yun‐Hsin Wang, Po‐Ju Lin, Chiung‐Fang Chang, Chiao‐Yin Sun, Yau‐Hung Chen
Coriander is a notable medicinal plant known for its diverse properties, including anti‐inflammatory, antioxidant, anticancer, analgesic, and anti‐diabetic effects. Despite its recognized health benefits, research on its nephroprotective properties is limited. This study aimed to investigate the potential nephroprotective properties of an aqueous extract derived from coriander leaves using an aristolochic
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Voacangine mitigates oxidative stress and neuroinflammation in middle cerebral artery occlusion‐induced cerebral ischemia/reperfusion injury by averting the NF‐κBp65/MAPK signaling pathways in rats Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-12 Bo Xu, Hua Wu, Wei Guo, Shaik Althaf Hussain, Tian Wang
Ischemic stroke is a leading cause of human mortality. Cerebral ischemia–reperfusion injury (CI/RI) is a primary cause of stroke. Ischemia–reperfusion (I/R) resulting in oxidative stress and inflammatory events may lead to severe neuronal impairments. Thus, anti‐oxidative and anti‐inflammatory mediators that can alleviate post‐I/R neuronal injuries are required for the treatment of CI/RI. An alkaloid
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Potato protein hydrolysate inhibits RANKL‐induced osteoclast development by inhibiting osteoclastogenic genes via the NF‐κB/MAPKs signaling pathways Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-12 Yi‐Ju Chen, Yen‐Hua He, Yun‐Hsin Lo, Hong‐Siang Yang, Mosleh Mohammad Abomughaid, K. J. Senthil Kumar, Wan‐Teng Lin
In recent times, there has been growing attention towards exploring the nutritional and functional aspects of potato protein, along with its diverse applications. In the present study, we examined the anti‐osteoclast properties of potato protein hydrolysate (PP902) in vitro. Murine macrophages (RAW264.7) were differentiated into osteoclasts by receptor activator of nuclear factor‐κB ligand (RANKL)
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A prognostic model established using bile acid genes to predict the immunity and survival of patients with gastrointestinal cancer Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-12 Xin Wu, Peifa Liu, Qing Wang, Linde Sun, Yu Wang
BackgroundThe metabolism of abnormal bile acids (BAs) is implicated in the initiation and development of gastrointestinal (GI) cancer. However, there was a lack of research on the molecular mechanisms of BAs metabolism in GI.MethodsGenes involved in BAs metabolism were excavated from public databases of The Cancer Genome Atlas (TCGA) database, Gene Expression Omnibus (GEO) database, and Molecular Signatures
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The immune landscape and prognostic analysis of CXCL8 immune‐related genes in cervical squamous cell carcinoma Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-10 Xiaoqian Zhang, Jian Yang, Qianqian Feng, Liping Gu, Gongzhao Qin, Chen Cheng, Shunyu Hou, Zhouhong Shi
Cervical squamous cell carcinoma (CESC), one of the most common malignancies in women, imposes a significant burden on women's health worldwide. Despite extensive research, the molecular and pathogenic mechanisms of cervical squamous cell carcinoma and CESC remain unclear. This study aimed to explore the immune‐related genes, immune microenvironment infiltration, and prognosis of CESC, providing a
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Role of formyl peptide receptor 2 in steatosis of L02 cells exposed to Mono‐(2‐ethylhexyl) phthalate Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-10 Xuemin Feng, Ruxuan Zhang, Xiaohan Miao, Xu Li, Jianwei Cui, Hang Xu, Xiaoqi Fang, Chunkui Zhou, Lin Ye, Liting Zhou
Mono‐(2‐ethylhexyl) phthalate (MEHP) can accumulate in the liver and then lead to hepatic steatosis, while the underlying mechanism remains unclear. Inflammation plays an important role in the disorder of hepatic lipid metabolism. This study aims to clarify the role of the inflammatory response mediated by formyl peptide receptor 2 (FPR2) in steatosis of L02 cells exposed to MEHP. L02 cells were exposed
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Interleukin‐4 inhibits the hypothalamic appetite control by modulating the insulin‐AKT and JAK‐STAT signaling in leptin mutant mice Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-10 Shu‐Mei Chen, Chiao‐Wan Hsiao, Yen‐Ju Chen, Chen‐Jee Hong, Jung‐Chun Lin, Ching‐Ping Yang, Yih‐Hsin Chang
Our previous research identified interleukin‐4 (IL‐4) as a key regulator of glucose/lipid metabolism, circulatory leptin levels, and insulin action, suggesting its potential as a therapeutic target for obesity and related complications. This study aimed to further elucidate the role of IL‐4 in regulating hypothalamic appetite‐controlling neuropeptides using leptin dysfunctional Leptin145E/145E mice
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Zinc finger Protein207 orchestrates glioma migration through regulation of epithelial‐mesenchymal transition Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-09 Chao Zhao, Yuduo Guo, Yujia Chen, Guanjie Shang, Dixiang Song, Jun Wang, Jingjing Yang, Hongwei Zhang
BackgroundGlioma represents the predominant primary malignant brain tumor. For several years, molecular profiling has been instrumental in the management and therapeutic stratification of glioma, providing a deeper understanding of its biological complexity. Accumulating evidence unveils the putative involvement of zinc finger proteins (ZNFs) in cancer. This study aimed to elucidate the role and significance
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Research on the toxicological prognostic significance of age‐related genes in endometrial cancer unveiling key factors in patient prognosis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-09 Yongchao Yin, Qian Niu, Zhiqiang Wei, Yefei Wang, Gang Li, Weican Zhang, Kai Guo, Xinyu Yao
This study investigates the influence of aging‐related genes on endometrial cancer, a prominent gynecological malignancy with rising incidence and mortality. By analyzing gene expression differences between cancerous and normal endometrial tissues, 42 aging‐related genes were identified as differentially expressed. Utilizing the TCGA‐UCEC sample, consensus clustering divided the samples into two molecular
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Advancing predictive markers in lung adenocarcinoma: A machine learning‐based immunotherapy prognostic prediction signature Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-09 Zhongyan Li, Shengbin Pei, Yanjuan Wang, Ge Zhang, Haoran Lin, Shiyang Dong
The prognosis of lung adenocarcinoma (LUAD) is generally poor. Immunotherapy has emerged as a promising therapeutic modality, demonstrating remarkable potential for substantially prolonging the overall survival of individuals afflicted with LUAD. However, there is currently a lack of reliable signatures for identifying patients who would benefit from immunotherapy. We conducted a comparative analysis
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miR‐29b‐3p targetedly regulates VEGF to inhibit tumor progression and cisplatin resistance through Nrf2/HO‐1 signaling pathway in non‐small cell lung cancer Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-08 Zhen Sun, Mingming Ren, Jieting Niu, Guojie Tang, Yanguang Li, Fanyi Kong, Xiang Song
BackgroundsNon‐small cell lung carcinoma (NSCLC) is a common type of lung cancer. Prior investigations have elucidated the pivotal role of miR‐29b‐3p in restraining tumor growth and metastasis. Nonetheless, it remains to be determined whether miR‐29b‐3p can effectively suppress NSCLC progression and enhance the sensitivity of NSCLC cells to cisplatin. This investigation sought to determine the mechanism
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PTPN7 mediates macrophage‐polarization and determines immunotherapy in gliomas: A single‐cell sequencing analysis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-06 Xiang Ji, Jingsong Cheng, Jing Su, Rong Wen, Qi Zhang, Guodong Liu, Yun Peng, Jinning Mao
BackgroundProtein tyrosine phosphatase non‐receptor type 7 (PTPN7) is a signaling molecule that regulates a multitude of cellular processes, spanning cell proliferation, cellular differentiation, the mitotic cycle, and oncogenic metamorphosis. However, the characteristic of PTPN7 in the glioma microenvironment has yet to be elucidated.MethodsThe prognostic value, genomic features, immune characteristics
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Decreases in the number of microglia and neural circuit dysfunction elicited by developmental exposure to neonicotinoid pesticides in mice Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-06 Kaede Namba, Takashi Tominaga, Yasuhiro Ishihara
Neonicotinoids are insecticides widely used in the world. Although neonicotinoids are believed to be toxic only to insects, their developmental neurotoxicity in mammals is a concern. Therefore, we examined the effects of developmental exposure to neonicotinoids on immune system in the brain and post‐developmental behaviors in this study. Imidacloprid or clothianidin was orally administered to dams
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Integrative analysis of the bladder cancer from a cell cycle NCAM1 perspective at both single cell and bulk resolution Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-06 Xiangju Zeng, Hao Su, Ziqi Liu, Yinhuai Wang, Zhijie Lu, Shunhua Cheng
IntroductionBladder cancer (BLCA) is a prevalent and deadly form of urinary cancer, and there is a need for effective therapies, particularly for muscle‐invasive bladder cancer (MIBC). Cell cycle inhibitors show promise in restoring control of the cell cycle in BLCA cells, but their clinical prognosis evaluation is limited.MethodsTranscriptome and scRNA‐seq data were collected from the Cancer Genome
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Identification of potential therapeutic targets for breast cancer using Mendelian randomization analysis and drug target prediction Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-06 Zhulan Huang, Hongping Zheng, Haiyu Wang, Haojie Ning, Aiwen Che, Cuidan Cai
Breast cancer stands as the foremost cause of cancer‐related mortality among women, presenting a substantial economic impact on society. The limitations in current therapeutic options, coupled with poor patient tolerance, underscore the urgent need for novel treatments. Our study embarked on a genomic association exploration of breast cancer, leveraging whole‐genome sequencing data from the Finngen
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RNA modification‐related EIF4G2 is an immunotherapy determinant in osteosarcoma: A single‐cell sequencing analysis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-05 Haocheng Qin, Shu Yang, Zhennan Feng, Song Wu, Ting Cai, Zijing Xie, Hai Hu
The clinical outcomes of osteosarcoma are relatively dismal. As immunotherapy has revolutionized treatment for solid tumors, exploring novel immunotherapy‐related therapeutic targets for osteosarcoma is important. In this study, we aimed to establish the connection between RNA modification and immunotherapy in osteosarcoma to identify novel therapeutic targets. An RNA modification‐related signature
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Single‐cell transcriptome sequencing analysis reveals intra‐tumor heterogeneity in esophageal squamous cell carcinoma Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-04 Yuanliu Nie, Guangyue Yao, Yanjun Wei, Sheng Wu, Wentao Zhang, Xiaoying Xu, Qiang Li, Fengge Zhou, Zhe Yang
Esophageal squamous cell carcinoma (ESCC) is a prevalent malignant tumor of the digestive system that poses a significant threat to human life and health. It is crucial to thoroughly investigate the mechanisms of esophageal carcinogenesis and identify potential key molecular events in its carcinogenesis. Single‐cell transcriptome sequencing is an emerging technology that has gained prominence in recent
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Globular adiponectin induces esophageal adenocarcinoma cell pyroptosis via the miR‐378a‐3p/UHRF1 axis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-04 Jun Wang, Yan Cheng, Yin Xiaoran, Fengrong Chen, Wu Jie, Huang Yahui, Wang Yue, Liu Dong, Luo Yumei, Feng Cheng, Zhang Libo, Zhang Jun
BackgroundAntiapoptosis is a major factor in the resistance of tumor cells to chemotherapy and radiotherapy. Thus, activation of cell pyroptosis may be an effective option to deal with antiapoptotic cancers such as esophageal adenocarcinoma (EAC).MethodsDifferential expression of ubiquitin‐like versus PHD and ring finger structural domain 1 (UHRF1) in EAC and near normal tissues was analyzed, as well
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How renal toxins respond to renal function deterioration and oral toxic adsorbent in pH‐controlled releasing capsule Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-04 Wen‐Sheng Liu, Shih‐Shin Liang, Mei‐Mei Cheng, Ming‐Tsan Wu, Szu‐Yuan Li, Tien‐Tien Cheng, Tsung‐Yun Liu, Ching‐Yao Tsai, Yen‐Ting Lai, Chien‐Hung Lin, Hsiang‐Tsui Wang, Han‐Hsing Tsou
The number of patients with chronic kidney disease (CKD) is increasing. Oral toxin adsorbents may provide some value. Several uremic toxins, including indoxyl sulfate (IS), p‐cresol (PCS), acrolein, per‐ and poly‐fluoroalkyl substances (PFAS), and inflammation markers (interleukin 6 [IL‐6] and tumor necrosis factor [TNF]‐alpha) have been shown to be related to CKD progression. A total of 81 patients
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Mitochondria‐associated endoplasmic reticulum membranes involve in oxidative stress‐induced intestinal barrier injury and mitochondrial dysfunction under diquat exposing Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-03 Feiyang Gou, Fengzhou Cai, Xin Li, Qian Lin, Jiang Zhu, Minjie Yu, Shaokui Chen, Jianjun Lu, Caihong Hu
Many factors induced by environmental toxicants have made oxidative stress a risk factor for the intestinal barrier injury and growth restriction, which is serious health threat for human and livestock and induces significant economic loss. It is well‐known that diquat‐induced oxidative stress is implicated in the intestinal barrier injury. Although some studies have shown that mitochondria are the
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Ketamine induces insomnia‐like symptom of zebrafish at environmentally relevant concentrations by mediating GABAergic synapse Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-03 Tingting Guo, Yuhang He, Shengqiang Mao, Ying Yang, Hongguan Xie, Sifan Zhang, Shuiping Dai
Although the stimulative effects on the normal behaviors of fish posed by ketamine (KET) were well‐studied, the adverse effects on the behavioral functions induced by KET at nighttime were unknown. Here, we used zebrafish larvae as a model exposed to KET (10, 50, 100, and 250 ng/L) at environmental levels for 21 days. The behavioral functions at nighttime, morphological changes during exposure stage
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Asiatic acid inhibits osteosarcoma cell migration and invasion via the AKT/Sp1/MMP1 axis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-03 Yat‐Yin Law, Hsiang‐Lin Lee, Chu‐Liang Lin, Pei‐Ni Chen, Pei‐Han Wang, Yi‐Hsien Hsieh, Chien‐Min Chen
Osteosarcoma is a malignant bone tumor affecting adolescents and children. No effective treatment is currently available. Asiatic acid (AA), a triterpenoid compound found in Centella asiatica, possesses anti‐tumor, anti‐inflammatory, and anti‐oxidant properties in various types of tumor cells. This study aims to determine whether AA exerts antitumor effects in human osteosarcoma cells. Our results
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Correction to “The protective activity of nanomicelle curcumin in bisphenol A‐induced cardiotoxicity following subacute exposure in rats.” Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-03
Valokola MG, Karimi G, Razavi BM, et al. The protective activity of nanomicelle curcumin in bisphenol A-induced cardiotoxicity following subacute exposure in rats. Environ Toxicol. 2019; 34: 319–329. https://doi.org/10.1002/tox.22687 In paragraph 2 of the “Materials and Methods” section, the text, “Each group consisted of 6 rats.” was incorrect. This should have read: “Each group consisted of 4-8 rats
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Elucidating the role of FOS in modulating the immune microenvironment through fibroblast and myeloid cell regulation in locoregional recurrent HNSCC Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-03 Shaokun Liu, Boxuan Han, Ru Wang, Jugao Fang
BackgroundHead and neck squamous cell carcinoma (HNSCC) presents a significant clinical challenge, particularly due to its high propensity for locoregional recurrence. Current research underscores the need to unravel the complex interactions within the tumor microenvironment. This study addresses the critical gap in understanding how FOS modulates the immune landscape in HNSCC, with a focus on its
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Melatonin promotes cell cycle progression of neural stem cells subjected to manganese via Nurr1 Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-02 Nan Chen, Han Zhou, Bin He, Sen Peng, Feng Ding, Qi‐Hao Liu, Zhuo Ma, Wei Liu, Bin Xu
Excessive exposure to manganese (Mn) through drinking water and food during pregnancy significantly heightens the likelihood of neurodevelopmental damage in offspring. Multiple studies have indicated that melatonin (Mel) may help to relieve neurodevelopmental disorders caused by Mn, but potential mechanisms underlying this effect require further exploration. Here, we utilized primary neural stem cells
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Development of gene panel for predicting recurrence in early‐stage cervical cancer patients Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-02 Yun Ma, Weipei Zhu
Cervical cancer (CC) is a common malignancy affecting women worldwide. Our objective was to develop a consensus‐based gene panel using multi‐omics data that could effectively predict recurrence in early‐stage cervical cancer patients. We utilized the “Multi‐Omics Consensus Integration Analysis (MOVICS)” package for consensus clustering design to integrate multiple omics datasets and improve the molecular
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Sensitivity of cholinesterases and carboxylesterases to pharmaceutical products in Tinca tinca Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-01 Ana‐Lourdes Oropesa, Blanca González‐Sánchez, Fernando J. Beltrán
Discharges to the aquatic environment of pharmaceuticals represent a hazard to the aquatic organisms. Subchronic assay with 17‐alpha‐ethinylestradiol (EE2) and in vitro essays with pharmaceuticals of environmental concern were conducted to examine the sensitivity of tissue acetylcholinesterase (AChE) and carboxylesterase (CbE) activities of Tinca tinca to them. Subchronic exposure to 17‐alpha‐EE2 caused
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Pachymic acid activates TP53INP2/TRAF6/caspase‐8 pathway to promote apoptosis in renal cell carcinoma cells Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-01 Xunjia Li, An He, Chengxuan Liu, Ying Li, Yan Luo, Weijian Xiong, Weiqi Nian, Deyu Zuo
While pachymic acid (PA), a key component of Poria cocos (Schw.), has demonstrated anti‐tumor effects in lung, breast, and pancreatic cancers, its impact on renal cell carcinoma (RCC) is unclear. This study evaluated the effect of PA on proliferation, migration, and apoptosis in human renal cancer A498 and ACHN cells as well as in cancer xenograft mice using wound scratch test, Western blotting, and
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LncRNA FRMD6‐AS1/miR‐491‐5p/USP13 pathway attenuated ferroptosis and contributed to liver fibrosis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-01 Ziqiang Li, Weilong Zou, Xiangren Jin, Yang Wang
Liver fibrosis is an invertible pathophysiologic process featured by excessive accumulation of extracellular matrix (ECM) which injures liver cells and activates hepatic stellate cells (HSCs). Besides, inducing ferroptosis in activated HSCs can alleviate liver fibrosis. LncRNAs modulate ferroptosis in activated HSCs and ECM deposition in liver fibrosis. However, the role of lncRNA FRMD6‐AS1 in liver
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Platycodi radix aqueous extract salvages doxorubicin‐induced senescence by mitochondrial reactive oxygen species reduction in umbilical cord matrix stem cells Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-01 Pei‐Ying Lee, Maria Angelina Sitorus, Chia‐Hua Kuo, Bruce Chi‐Kang Tsai, Wei‐Wen Kuo, Kuan‐Ho Lin, Shang‐Yeh Lu, Yueh‐Min Lin, Tsung‐Jung Ho, Chih‐Yang Huang
Platycodi radix is a widely used herbal medicine that contains numerous phytochemicals beneficial to health. The health and biological benefits of P. radix have been found across various diseases. The utilization of umbilical cord stromal stem cells, derived from Wharton's jelly of the human umbilical cord, has emerged as a promising approach for treating degenerative diseases. Nevertheless, growing
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Hedgehog pathway negatively regulated depleted uranium‐induced nephrotoxicity Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-28 Xueying Xie, Guoquan Fu, Yuxin Liu, Caixia Fan, Shanshan Tan, Huarong Huang, Junyan Yan, Lifang Jin
Depleted uranium (DU) retains the radiological toxicities, which accumulates preferentially in the kidneys. Hedgehog (Hh) pathway plays a critical role in tissue injury. However, the role of Hh in DU‐induced nephrotoxicity was still unclear. This study was carried out to investigate the effect of Gli2, which was an important transcription effector of Hh signaling, on DU induced nephrotoxicity. To clarify
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Immunotoxicity of ionic liquid [C14mim]BF4 in rats Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-28 Manyu Shu, Pengzhen Tan, Yueyue Ge, Xingxing Tian, Hongmei Xu
Ionic liquid tetrafluoroborated‐1‐tetradecyl‐3‐methylimidazole salt ([C14mim]BF4) immunotoxicity was investigated in rats using three exposure groups (12.5, 25, and 50 mg kg−1), one recovery group (50 mg kg−1), and a control group without any treatment. The findings demonstrated that, at low doses, [C14mim]BF4 could raise WBC, NEU, and MID and lysozyme levels as well as spleen T‐lymphocyte stimulation
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Circ_0027791 contributes to the growth and immune evasion of hepatocellular carcinoma via the miR‐496/programmed cell death ligand 1 axis in an m6A‐dependent manner Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-28 Furong Yu, Peifei Fang, Yonghong Fang, Daojun Chen
Emerging evidence indicates the critical roles of circular RNAs in the development of multiple cancers, containing hepatocellular carcinoma (HCC). Herein, our present research reported the biological function and mechanism of circ_0027791 in HCC progression. Circ_0027791, microRNA‐496 (miR‐496), programmed cell death ligand 1 (PDL1), and methyltransferase‐like 3 (METTL3) levels were detected by real‐time
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Nephroprotective effects of silymarin and its fabricated nanoparticles against aluminum‐induced oxidative stress, hyperlipidemia, and genotoxicity Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-28 Fatma M. El‐Demerdash, Manal M. Ahmed, Raghda A. El‐Sayed, Tarek M. Mohemed, Marian N. Gerges
BackgroundAluminum (Al) is a ubiquitous element with proven nephrotoxicity. Silymarin (SM) is a mixture of polyphenolic components extracted from Silybum marianum and exhibited protective influences. However, SM bioactivity can be enhanced by its incorporation in chitosan (CS) through the use of nanotechnology. This work proposed to assess the protective influence of SM and its loaded chitosan nanoparticles
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Exploring gene biomarkers and targeted drugs for ferroptosis and cuproptosis in osteosarcoma: A bioinformatic approach Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-28 Yingnan Ji, Lv Liu, Yu Liu, Yudong Ma, Zhenhua Ji, Xiaodan Wu, Qi Zhu
Osteosarcoma predominantly affects adolescents and young adults and is characterized as a malignant bone tumor. In recent decades, substantial advancements have been achieved in both diagnosing and treating osteosarcoma. Resulting in enhanced survival rates. Despite these advancements, the intricate relationship between ferroptosis and cuproptosis genes in osteosarcoma remains inadequately understood
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Epigenetic activation of METTL14 promotes docetaxel resistance in prostate cancer by promoting pri‐microRNA‐129 maturation Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-28 Cheng Wu, Chunqing Miao, Songlin Zhou, Ping‐an Chang, Bin He, Xunrong Zhou, Qingsheng Tang
The development of resistance to Docetaxel (DTX) compromises its therapeutic efficacy and worsens the prognosis of prostate cancer (PCa), while the underlying regulatory mechanism remains poorly understood. In this study, METTL14 was found to be upregulated in DTX‐resistant PCa cells and PCa tissues exhibiting progressive disease during DTX therapy. Furthermore, overexpression of METTL14 promoted the
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Regulatory T cells subgroups in the tumor microenvironment cannot be overlooked: Their involvement in prognosis and treatment strategy in melanoma Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-26 Wenyi Huang, Byeong Seop Kim, Yichi Zhang, Li Lin, Gang Chai, Zhijie Zhao
BackgroundMelanoma, the most lethal form of skin cancer, presents substantial challenges despite effective surgical interventions for in situ lesions. Regulatory T cells (Tregs) wield a pivotal immunomodulatory influence within the tumor microenvironment, yet their impact on melanoma prognosis and direct molecular interactions with melanoma cells remain elusive. This investigation employs single‐cell
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Sinapic acid protects against lead acetate‐induced lung toxicity by reducing oxidative stress, apoptosis, inflammation, and endoplasmic reticulum stress damage Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-26 Nurhan Akaras, Sefa Kucukler, Cihan Gur, Mustafa Ileriturk, Fatih Mehmet Kandemir
Lead acetate (PbAc) is a compound that produces toxicity in many tissues after exposure. Sinapic acid (SNP) possesses many biological and pharmacological properties. This study aimed to investigate the efficacy of SNP on the toxicity of PbAc in lung tissue. PbAc was administered orally at 30 mg/kg and SNP at 5 or 10 mg/kg for 7 days. Biochemical, genetic, and histological methods were used to investigate
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The inhibition of MARCO by PolyG alleviates pulmonary fibrosis via regulating mitochondrial function in a silicotic rat model Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-25 Meiyu Chang, Ning Li, Qiang Zhou, Yaomin Yan, Weiwei Xu, Yingzheng Zhao, Sanqiao Yao
Silicon dioxide (SiO2)‐induced pulmonary fibrosis is potentially associated with the impairment of mitochondrial function. Previous research found that inhibition of macrophage receptor with collagenous structure (MARCO) could alleviate particle‐induced lung injury by regulating phagocytosis and mitigating mitochondrial damage. The present study aims to explore the underlying anti‐fibrosis mechanism
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Regulatory mechanism of the Glabrene against non‐small cell lung cancer by suppressing FGFR3 Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-22 Miao He, Huiling Wu, Lingjing Hu, Nan Liu, Guoduo Zhang, Shumei Wang
BackgroundNon‐small cell lung cancer (NSCLC) is a highly malignant tumor with limited effective treatment options. This study aimed to investigate the regulatory mechanism of Glabrene on NSCLC through its interaction with FGFR3.MethodsHCC827 cells were implanted into nude mice and treated with Glabrene. Tumor volume was monitored at 0, 3, 6, and 9 days after medical treatment. Tissue analysis included
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Hibifolin protected pro‐inflammatory response and oxidative stress in LPS‐induced acute lung injury through antioxidative enzymes and the AMPK2/Nrf‐2 pathway Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-21 Yung‐Lun Ni, Huan‐Ting Shen, Yan‐Yan Ng, Shih‐Pin Chen, Shiuan‐Shinn Lee, Ching‐Chi Tseng, Yung‐Chuan Ho, Yu‐Hsiang Kuan
ALI is a grave medical ailment that manifests as abrupt inflammation of the lungs and diminished oxygen levels. It poses a considerable challenge to the medical fraternity, with elevated rates of morbidity and mortality. Our research endeavors to investigate the potential of hibifolin, a flavonoid glucuronide, imbued with potent antioxidant properties, and its molecular mechanism to combat LPS‐induced
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Discovery of the tryptanthrin‐derived indoloquinazoline as an anti‐breast cancer agent via ERK/JNK activation Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-21 Chih‐Shiang Chang, Li‐Yuan Bai, Chang‐Fang Chiu, Jing‐Lan Hu, Jing‐Ru Weng
Tryptanthrin, an alkaloid applied in traditional Chinese medicine, exhibits a variety of pharmacological activities. This study aimed to investigate the anti‐tumor activity of the tryptanthrin derivative (8‐cyanoindolo[2,1‐b]quinazoline‐6,12‐dione [CIQ]) in breast cancer cells. In both MDA‐MB‐231 and MCF‐7 breast cancer cells, CIQ inhibited cell viability and promoted caspase‐dependent apoptosis. At
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Comprehensive prognostic assessment in kidney cancer: A multidimensional approach analyzing Fufang Sanling granules, genetic variants, and immune infiltration Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-21 Junlan Zhu, Yun Ye, Xin Zhao, Meiling Wu, Xuyao Wang, Peng Shu, Jian Liu, Xingguo Zhang
This study delves into the potential therapeutic benefits of Fufang Sanling Granules for kidney cancer, focusing on their active components and the underlying mechanisms of their interaction with cancer‐related targets. By constructing a drug‐active component‐target network based on eight herbs, key active compounds such as kaempferol, quercetin, and linolenic acid were identified, suggesting their
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Arsenic exposure induced renal fibrosis via regulation of mitochondrial dynamics and the NLRP3‐TGF‐β1/SMAD signaling pathway Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-21 Miaomiao Ren, Jing Li, Zehua Xu, Bingru Nan, Hongying Gao, Heng Wang, Yi Lin, Heqing Shen
Environmental arsenic exposure is one of the major global public health problems. Studies have shown that arsenic exposure can cause renal fibrosis, but the underlying mechanism is still unclear. Integrating the in vivo and in vitro models, this study investigated the potential molecular pathways for arsenic‐induced renal fibrosis. In this study, SD rats were treated with 0, 5, 25, 50, and 100 mg/L
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Integrative analysis of bulk RNA‐seq and scRNA‐seq data indicates the prognostic and immunologic values of SERPINH1 in glioma Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-20 Shiqiang Hou, Yinan Chen, Chunjing Jin, Ning Lin
BackgroundSERPINH1 is abnormally expressed in multiple cancers and is associated with malignant progression. However, few reports detail its role in the etiopathogenesis of glioma. Hence, the aim of this article was to investigate the potential value of SERPINH1 in glioma using an integrative analysis.MethodsData of RNA‐seq and scRNA‐seq was obtained and evaluated using online databases. The expression
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Targeting the PI3K/pAKT/mTOR/NF‐κB/FOXO3a signaling pathway for suppressing the development of hepatocellular carcinoma in rats: Role of the natural remedic Suaeda vermiculata forssk Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-20 Mohamed S. Abdel‐Bakky, Hamdoon A. Mohammed, Nesreen I. Mahmoud, Elham Amin, Mansour Alsharidah, Osamah Al Rugaie, Mohamed G. Ewees
Liver malignancy is well recognized as a prominent health concern, with numerous treatment options available. Natural products are considered a renewable source, providing inspiring chemical moieties that could be used for cancer treatment. Suaeda vermiculata Forssk has traditionally been employed for management of hepatic conditions, including liver inflammation, and liver cirrhosis, as well as to
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Effect of chlorpyrifos‐exposure on the expression levels of CYP genes in Daphnia magna and examination of a possibility that an up‐regulated clan 3 CYP, CYP360A8, reacts with pesticides Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-20 Shinpei Ohnuki, Shinichi Tokishita, Masaki Kojima, Shoko Fujiwara
Daphnia magna is a test organism used for ecological risk assessments of pesticides, but little is known about the expression levels of cytochrome P450s (CYP)s and their changes after pesticide exposure in the less than 24‐h‐olds used for ecotoxicity tests. In this study, D. magna juveniles were exposed to 0.2 μg/L of chlorpyrifos under the conditions for acute immobilization test as specified by the
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The stimulation of exosome generation by visfatin polarizes M2 macrophages and enhances the motility of chondrosarcoma Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-18 Chang‐Yu Song, Chih‐Ying Wu, Chih‐Yang Lin, Chun‐Hao Tsai, Hsien‐Te Chen, Yi‐Chin Fong, Li‐Chai Chen, Chih‐Hsin Tang
Chondrosarcoma is a malignant bone tumor that arises from abnormalities in cartilaginous tissue and is associated with lung metastases. Extracellular vesicles called exosomes are primarily used as mediators of intercellular signal transmission to control tumor metastasis. Visfatin is an adipokine reported to enhance tumor metastasis, but its relationship with exosome generation in chondrosarcoma motility
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Down‐regulating lncRNA KCNQ1OT1 relieves type II alveolar epithelial cell apoptosis during one‐lung ventilation via modulating miR‐129‐5p/HMGB1 axis induced pulmonary endothelial glycocalyx Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Zhenghuan Song, Zhongqiu Wang, Jiaqin Cai, Yihu Zhou, Yueyi Jiang, Jing Tan, Lianbin Gu
ObjectiveEndothelial glycocalyx (EG) maintains vascular homeostasis and is destroyed after one‐lung ventilation (OLV)‐induced lung injury. Long noncoding RNAs (lncRNAs) are critically involved in various lung injuries. This study aimed to investigate the role and regulatory mechanism of KCNQ1 overlapping transcript 1 (KCNQ1OT1) in OLV‐induced lung injury and LPS‐induced type II alveolar epithelial
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Exploring the tumor microenvironment: Chemokine‐related genes and immunotherapy/chemotherapy response in clear‐cell renal cell carcinoma Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Yuhao Meng, Chen Zhang, Tongfei Fu, Jiaheng He, Junsong Wu, Yongli Zhan
BackgroundThe treatment of clear‐cell renal cell carcinoma (ccRCC) remains challenge. Chemokines laid impact on the proliferation and metastasis of cancer cells. The objective was to identify the chemokine‐related genes and construct a prognostic model for ccRCC.MethodsBulk transcriptomic data (n = 531), single‐cell RNA sequencing (scRNA‐seq) dataset GSE159115, and other validation cohorts were acquired
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LncRNA MRAK052509 competitively adsorbs miR‐204‐3p to regulate silica dust‐induced EMT process Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Liu Xuan, Jiao Zi‐ming, Tian Xue‐yan, Hu Wen‐xuan, Wang Fa‐xuan
Silicosis is a systemic disease caused by long‐term inhalation of free SiO2 and retention in the lungs. At present, it is still the most important occupational health hazard disease in the world. Existing studies have shown that non‐coding RNA can also participate in complex fibrosis regulatory networks. However, its role in regulating silicotic fibrosis is still unclear. In this study, we constructed
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Protein phosphatase 2A modulation and connection with miRNAs and natural products Environ. Toxicol. (IF 4.5) Pub Date : 2024-03-16 Ya‐Ting Chuang, Ching‐Yu Yen, Jen‐Yang Tang, Fang‐Rong Chang, Yi‐Hong Tsai, Kuo‐Chuan Wu, Tsu‐Ming Chien, Hsueh‐Wei Chang
Protein phosphatase 2A (PP2A), a heterotrimeric holoenzyme (scaffolding, catalytic, and regulatory subunits), regulates dephosphorylation for more than half of serine/threonine phosphosites and exhibits diverse cellular functions. Although several studies on natural products and miRNAs have emphasized their impacts on PP2A regulation, their connections lack systemic organization. Moreover, only part