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Deciphering the prognostic landscape of osteosarcoma: Integrating the roles of hippo pathway genes, programmed cell death, and the tumor immune microenvironment Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-16 Huayan Ma, Yuxian Zhang, Jing Li, Tiantian Xie, Zhi Zhao
Osteosarcoma is a highly aggressive cancer prevalent among adolescents and young adults, notorious for its tendency to metastasize to the lungs. This research delves into the molecular foundations of osteosarcoma by examining the role of the Hippo signaling pathway and its interaction with the tumor immune microenvironment (TME). Through analysis of transcriptomic data from the TARGET‐OS dataset and
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Single‐cell and bulk RNA‐sequencing reveal SPP1 and CXCL12 as cell‐to‐cell communication markers to predict prognosis in lung adenocarcinoma Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-16 Zengtuan Xiao, Zhe Nian, Mengzhe Zhang, Zuo Liu, Pengpeng Zhang, Zhenfa Zhang
Lung adenocarcinoma (LUAD) generally presents as an immunosuppressive microenvironment. The characteristics of cell‐to‐cell communication in the LUAD microenvironment has been unclear. In this study, the LUAD bulk RNA‐seq data and single‐cell RNA‐seq data were retrieved from public dataset. Differential expression genes (DEGs) between LUAD tumor and adjacent non‐tumor tissues were calculated by limma
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Teaghrelin protected dopaminergic neurons in MPTP‐induced Parkinson's disease animal model by promoting PINK1/Parkin‐mediated mitophagy and AMPK/SIRT1/PGC1‐α‐mediated mitochondrial biogenesis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-16 Cian‐Fen Jhuo, Chun‐Jung Chen, Jason T.C. Tzen, Wen‐Ying Chen
Mitochondrial dysfunction, a common cellular hallmark in both familial and sporadic forms of Parkinson's disease (PD), is assumed to play a significant role in pathologic development and progression of the disease. Teaghrelin, a unique bioactive compound in some oolong tea varieties, has been demonstrated to protect SH‐SY5Y cells against 1‐methyl‐4‐phenylpyridinium induced neurotoxicity by binding
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Deciphering programmed cell death mechanisms in osteosarcoma for prognostic modeling Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-16 Jingyang Chen, Tengdi Fan, Lingxiao Pan, Hanshi Yang
Osteosarcoma (OS), known for its high recurrence and metastasis rates, poses a significant challenge in oncology. Our research investigates the role of programmed cell death (PCD) genes in OS and develops a prognostic model using advanced bioinformatics. We analyzed single‐cell sequencing data from the Gene Expression Omnibus (GEO) database to identify subpopulations, distinguish malignant from non‐malignant
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Comprehensive analysis of lung adenocarcinoma: Unveiling differential gene expression, survival‐linked genes, subtype stratification, and immune landscape implications Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-15 Yong Xi, Liu Xi, Jian Tan, Chaoqun Yu, Weiyu Shen, Bentong Yu
This study offers a detailed exploration of lung adenocarcinoma (LUAD), addressing its heterogeneity and treatment challenges through a multi‐faceted analysis that includes gene expression, genetic subtyping, pathway analysis, immune assessment, and drug sensitivity. It identifies 165 genes with significant expression differences and 46 genes associated with survival, revealing insights into oxidative
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Nephroprotective effects of coriander (Coriandrum sativum) leaves aqueous extracts in aristolochic acid‐intoxicated zebrafish embryos Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-13 Jen‐Ning Tsai, Yun‐Hsin Wang, Po‐Ju Lin, Chiung‐Fang Chang, Chiao‐Yin Sun, Yau‐Hung Chen
Coriander is a notable medicinal plant known for its diverse properties, including anti‐inflammatory, antioxidant, anticancer, analgesic, and anti‐diabetic effects. Despite its recognized health benefits, research on its nephroprotective properties is limited. This study aimed to investigate the potential nephroprotective properties of an aqueous extract derived from coriander leaves using an aristolochic
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Voacangine mitigates oxidative stress and neuroinflammation in middle cerebral artery occlusion‐induced cerebral ischemia/reperfusion injury by averting the NF‐κBp65/MAPK signaling pathways in rats Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-12 Bo Xu, Hua Wu, Wei Guo, Shaik Althaf Hussain, Tian Wang
Ischemic stroke is a leading cause of human mortality. Cerebral ischemia–reperfusion injury (CI/RI) is a primary cause of stroke. Ischemia–reperfusion (I/R) resulting in oxidative stress and inflammatory events may lead to severe neuronal impairments. Thus, anti‐oxidative and anti‐inflammatory mediators that can alleviate post‐I/R neuronal injuries are required for the treatment of CI/RI. An alkaloid
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Potato protein hydrolysate inhibits RANKL‐induced osteoclast development by inhibiting osteoclastogenic genes via the NF‐κB/MAPKs signaling pathways Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-12 Yi‐Ju Chen, Yen‐Hua He, Yun‐Hsin Lo, Hong‐Siang Yang, Mosleh Mohammad Abomughaid, K. J. Senthil Kumar, Wan‐Teng Lin
In recent times, there has been growing attention towards exploring the nutritional and functional aspects of potato protein, along with its diverse applications. In the present study, we examined the anti‐osteoclast properties of potato protein hydrolysate (PP902) in vitro. Murine macrophages (RAW264.7) were differentiated into osteoclasts by receptor activator of nuclear factor‐κB ligand (RANKL)
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A prognostic model established using bile acid genes to predict the immunity and survival of patients with gastrointestinal cancer Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-12 Xin Wu, Peifa Liu, Qing Wang, Linde Sun, Yu Wang
BackgroundThe metabolism of abnormal bile acids (BAs) is implicated in the initiation and development of gastrointestinal (GI) cancer. However, there was a lack of research on the molecular mechanisms of BAs metabolism in GI.MethodsGenes involved in BAs metabolism were excavated from public databases of The Cancer Genome Atlas (TCGA) database, Gene Expression Omnibus (GEO) database, and Molecular Signatures
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The immune landscape and prognostic analysis of CXCL8 immune‐related genes in cervical squamous cell carcinoma Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-10 Xiaoqian Zhang, Jian Yang, Qianqian Feng, Liping Gu, Gongzhao Qin, Chen Cheng, Shunyu Hou, Zhouhong Shi
Cervical squamous cell carcinoma (CESC), one of the most common malignancies in women, imposes a significant burden on women's health worldwide. Despite extensive research, the molecular and pathogenic mechanisms of cervical squamous cell carcinoma and CESC remain unclear. This study aimed to explore the immune‐related genes, immune microenvironment infiltration, and prognosis of CESC, providing a
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Role of formyl peptide receptor 2 in steatosis of L02 cells exposed to Mono‐(2‐ethylhexyl) phthalate Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-10 Xuemin Feng, Ruxuan Zhang, Xiaohan Miao, Xu Li, Jianwei Cui, Hang Xu, Xiaoqi Fang, Chunkui Zhou, Lin Ye, Liting Zhou
Mono‐(2‐ethylhexyl) phthalate (MEHP) can accumulate in the liver and then lead to hepatic steatosis, while the underlying mechanism remains unclear. Inflammation plays an important role in the disorder of hepatic lipid metabolism. This study aims to clarify the role of the inflammatory response mediated by formyl peptide receptor 2 (FPR2) in steatosis of L02 cells exposed to MEHP. L02 cells were exposed
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Interleukin‐4 inhibits the hypothalamic appetite control by modulating the insulin‐AKT and JAK‐STAT signaling in leptin mutant mice Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-10 Shu‐Mei Chen, Chiao‐Wan Hsiao, Yen‐Ju Chen, Chen‐Jee Hong, Jung‐Chun Lin, Ching‐Ping Yang, Yih‐Hsin Chang
Our previous research identified interleukin‐4 (IL‐4) as a key regulator of glucose/lipid metabolism, circulatory leptin levels, and insulin action, suggesting its potential as a therapeutic target for obesity and related complications. This study aimed to further elucidate the role of IL‐4 in regulating hypothalamic appetite‐controlling neuropeptides using leptin dysfunctional Leptin145E/145E mice
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Zinc finger Protein207 orchestrates glioma migration through regulation of epithelial‐mesenchymal transition Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-09 Chao Zhao, Yuduo Guo, Yujia Chen, Guanjie Shang, Dixiang Song, Jun Wang, Jingjing Yang, Hongwei Zhang
BackgroundGlioma represents the predominant primary malignant brain tumor. For several years, molecular profiling has been instrumental in the management and therapeutic stratification of glioma, providing a deeper understanding of its biological complexity. Accumulating evidence unveils the putative involvement of zinc finger proteins (ZNFs) in cancer. This study aimed to elucidate the role and significance
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Research on the toxicological prognostic significance of age‐related genes in endometrial cancer unveiling key factors in patient prognosis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-09 Yongchao Yin, Qian Niu, Zhiqiang Wei, Yefei Wang, Gang Li, Weican Zhang, Kai Guo, Xinyu Yao
This study investigates the influence of aging‐related genes on endometrial cancer, a prominent gynecological malignancy with rising incidence and mortality. By analyzing gene expression differences between cancerous and normal endometrial tissues, 42 aging‐related genes were identified as differentially expressed. Utilizing the TCGA‐UCEC sample, consensus clustering divided the samples into two molecular
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Advancing predictive markers in lung adenocarcinoma: A machine learning‐based immunotherapy prognostic prediction signature Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-09 Zhongyan Li, Shengbin Pei, Yanjuan Wang, Ge Zhang, Haoran Lin, Shiyang Dong
The prognosis of lung adenocarcinoma (LUAD) is generally poor. Immunotherapy has emerged as a promising therapeutic modality, demonstrating remarkable potential for substantially prolonging the overall survival of individuals afflicted with LUAD. However, there is currently a lack of reliable signatures for identifying patients who would benefit from immunotherapy. We conducted a comparative analysis
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Nanoplastics aggravated TDCIPP-induced transgenerational developmental neurotoxicity in zebrafish depending on the involvement of the dopamine signaling pathway Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-09 Xin Ren, Zhibo Liu, Ruiqi Zhang, Yuting Shao, Xiaoyue Duan, Bo Sun, Xuesong Zhao
Plastics pose a hazard to the environment. Although plastics have toxicity, microplastics (MPs) and nanoplastics (NPs) are capable of interacting with the rest pollutants in the environment, so they serve as the carriers and interact with organic pollutants to modulate their toxicity, thus resulting in unpredictable ecological risks. PS-NPs and TDCIPP were used expose from 2 h post-fertilization (hpf)
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miR‐29b‐3p targetedly regulates VEGF to inhibit tumor progression and cisplatin resistance through Nrf2/HO‐1 signaling pathway in non‐small cell lung cancer Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-08 Zhen Sun, Mingming Ren, Jieting Niu, Guojie Tang, Yanguang Li, Fanyi Kong, Xiang Song
BackgroundsNon‐small cell lung carcinoma (NSCLC) is a common type of lung cancer. Prior investigations have elucidated the pivotal role of miR‐29b‐3p in restraining tumor growth and metastasis. Nonetheless, it remains to be determined whether miR‐29b‐3p can effectively suppress NSCLC progression and enhance the sensitivity of NSCLC cells to cisplatin. This investigation sought to determine the mechanism
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PTPN7 mediates macrophage‐polarization and determines immunotherapy in gliomas: A single‐cell sequencing analysis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-06 Xiang Ji, Jingsong Cheng, Jing Su, Rong Wen, Qi Zhang, Guodong Liu, Yun Peng, Jinning Mao
BackgroundProtein tyrosine phosphatase non‐receptor type 7 (PTPN7) is a signaling molecule that regulates a multitude of cellular processes, spanning cell proliferation, cellular differentiation, the mitotic cycle, and oncogenic metamorphosis. However, the characteristic of PTPN7 in the glioma microenvironment has yet to be elucidated.MethodsThe prognostic value, genomic features, immune characteristics
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Decreases in the number of microglia and neural circuit dysfunction elicited by developmental exposure to neonicotinoid pesticides in mice Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-06 Kaede Namba, Takashi Tominaga, Yasuhiro Ishihara
Neonicotinoids are insecticides widely used in the world. Although neonicotinoids are believed to be toxic only to insects, their developmental neurotoxicity in mammals is a concern. Therefore, we examined the effects of developmental exposure to neonicotinoids on immune system in the brain and post‐developmental behaviors in this study. Imidacloprid or clothianidin was orally administered to dams
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Integrative analysis of the bladder cancer from a cell cycle NCAM1 perspective at both single cell and bulk resolution Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-06 Xiangju Zeng, Hao Su, Ziqi Liu, Yinhuai Wang, Zhijie Lu, Shunhua Cheng
IntroductionBladder cancer (BLCA) is a prevalent and deadly form of urinary cancer, and there is a need for effective therapies, particularly for muscle‐invasive bladder cancer (MIBC). Cell cycle inhibitors show promise in restoring control of the cell cycle in BLCA cells, but their clinical prognosis evaluation is limited.MethodsTranscriptome and scRNA‐seq data were collected from the Cancer Genome
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Identification of potential therapeutic targets for breast cancer using Mendelian randomization analysis and drug target prediction Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-06 Zhulan Huang, Hongping Zheng, Haiyu Wang, Haojie Ning, Aiwen Che, Cuidan Cai
Breast cancer stands as the foremost cause of cancer‐related mortality among women, presenting a substantial economic impact on society. The limitations in current therapeutic options, coupled with poor patient tolerance, underscore the urgent need for novel treatments. Our study embarked on a genomic association exploration of breast cancer, leveraging whole‐genome sequencing data from the Finngen
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Impact of endocrine-active compounds on adrenal androgen production in pigs during neonatal period Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-06 Katarzyna Knapczyk-Stwora, Aleksandra Kozlowska, Damian Jastrzabek, Malgorzata Grzesiak, Maria Slomczynska, Marek Koziorowski
This study investigated the impact of neonatal exposure to endocrine-active compounds (EACs): flutamide (antiandrogen), 4--octylphenol (an estrogenic compound), and methoxychlor (an organochlorine insecticide exhibiting estrogenic, antiestrogenic and antiandrogenic activities) on androgen production within porcine adrenal glands. The expression of genes related to androgen synthesis and the level of
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Variation of total alpha and beta activities and Rn-222 concentrations in the water supply system of an Italian volcanic region: How safe is tap water for human consumption? J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-05 Antonio Iannone, Stefano Albanese, Annalise Guarino, Maurizio Ambrosino, Giancarlo Germano, Giancarlo De Tullio, Domenico Cicchella
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Comprehensive bioremediation effect of phosphorus-mineralized bacterium Enterobacter sp. PMB-5 on cadmium contaminated soil-crop system J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-05 Huayan Huang, Ling Lei, Yuxian Shangguan, Jiannan Jian, Jingtong Dai, Yang Wang, Heng Xu, Huakang Liu
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RNA modification‐related EIF4G2 is an immunotherapy determinant in osteosarcoma: A single‐cell sequencing analysis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-05 Haocheng Qin, Shu Yang, Zhennan Feng, Song Wu, Ting Cai, Zijing Xie, Hai Hu
The clinical outcomes of osteosarcoma are relatively dismal. As immunotherapy has revolutionized treatment for solid tumors, exploring novel immunotherapy‐related therapeutic targets for osteosarcoma is important. In this study, we aimed to establish the connection between RNA modification and immunotherapy in osteosarcoma to identify novel therapeutic targets. An RNA modification‐related signature
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Growth and physiological responses of submerged macrophytes to linear alkylbenzene sulfonate (LAS) Environ. Toxicol. Pharmacol. (IF 4.3) Pub Date : 2024-04-05 Cui-Min Han, Wen-Hua You
The potential toxic effects of linear alkylbenzene sulfonate (LAS), widely used in commercial detergents and cleaners, on submerged macrophytes remain unclear. We conducted a two-week exposure experiment to investigate LAS toxicity on five submerged macrophytes (four native and one exotic), focusing on their growth and physiological responses. The results showed that lower concentrations of LAS (<
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Molecular imprinting-based triple-emission ratiometric fluorescence sensor with aggregation-induced emission effect for visual detection of doxycycline J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-04 Jiaqi Miao, Jialuo Yu, Xinming Zhao, Xinru Chen, Congzheng Zhu, Xin Cao, Yan Huang, Bowei Li, Yixuan Wu, Lingxin Chen, Xiaoyan Wang
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Complete biodegradation of tetrabromobisphenol A through sequential anaerobic reductive dehalogenation and aerobic oxidation J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-04 Guiping Liu, Songmeng Liu, Jie Yang, Xiaoyang Zhang, Lianghua Lu, Hongxia Xu, Shujun Ye, Jichun Wu, Jiandong Jiang, Wenjing Qiao
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Swellable microneedle-coupled light-addressable photoelectrochemical sensor for in-situ tracking of multiple pesticides pollution in vivo J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-04 Jinmiao Wang, Yanwen Liu, Cheng Yu, Xinmeng Wang, Juan Wang
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Deterioration phenomenon of Pb-contaminated aqueous solution remediation and enhancement mechanism of nano-hydroxyapatite-assisted biomineralization J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-04 Yi-Xin Xie, Wen-Chieh Cheng, Zhong-Fei Xue, Md Mizanur Rahman, Lin Wang
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Rational design of a hydrophilic nanoarray-structured electro-Fenton membrane for antibiotics removal and fouling mitigation: An intensified catalysis process in an oxygen vacancy‐mediated cathodic microreactor J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-04 Liu Yang, Jing Zhao, Daliang Xu, Xinsheng Luo, Yonghui Han, Xiaobin Tang, Heng Liang
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Single‐cell transcriptome sequencing analysis reveals intra‐tumor heterogeneity in esophageal squamous cell carcinoma Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-04 Yuanliu Nie, Guangyue Yao, Yanjun Wei, Sheng Wu, Wentao Zhang, Xiaoying Xu, Qiang Li, Fengge Zhou, Zhe Yang
Esophageal squamous cell carcinoma (ESCC) is a prevalent malignant tumor of the digestive system that poses a significant threat to human life and health. It is crucial to thoroughly investigate the mechanisms of esophageal carcinogenesis and identify potential key molecular events in its carcinogenesis. Single‐cell transcriptome sequencing is an emerging technology that has gained prominence in recent
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Globular adiponectin induces esophageal adenocarcinoma cell pyroptosis via the miR‐378a‐3p/UHRF1 axis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-04 Jun Wang, Yan Cheng, Yin Xiaoran, Fengrong Chen, Wu Jie, Huang Yahui, Wang Yue, Liu Dong, Luo Yumei, Feng Cheng, Zhang Libo, Zhang Jun
BackgroundAntiapoptosis is a major factor in the resistance of tumor cells to chemotherapy and radiotherapy. Thus, activation of cell pyroptosis may be an effective option to deal with antiapoptotic cancers such as esophageal adenocarcinoma (EAC).MethodsDifferential expression of ubiquitin‐like versus PHD and ring finger structural domain 1 (UHRF1) in EAC and near normal tissues was analyzed, as well
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How renal toxins respond to renal function deterioration and oral toxic adsorbent in pH‐controlled releasing capsule Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-04 Wen‐Sheng Liu, Shih‐Shin Liang, Mei‐Mei Cheng, Ming‐Tsan Wu, Szu‐Yuan Li, Tien‐Tien Cheng, Tsung‐Yun Liu, Ching‐Yao Tsai, Yen‐Ting Lai, Chien‐Hung Lin, Hsiang‐Tsui Wang, Han‐Hsing Tsou
The number of patients with chronic kidney disease (CKD) is increasing. Oral toxin adsorbents may provide some value. Several uremic toxins, including indoxyl sulfate (IS), p‐cresol (PCS), acrolein, per‐ and poly‐fluoroalkyl substances (PFAS), and inflammation markers (interleukin 6 [IL‐6] and tumor necrosis factor [TNF]‐alpha) have been shown to be related to CKD progression. A total of 81 patients
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Comparison of gut toxicity and microbiome effects in zebrafish exposed to polypropylene microplastics: Interesting effects of UV-weathering on microbiome J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-03 Jin Soo Choi, Hakwon Yoon, Yunwi Heo, Tae Hee Kim, June-Woo Park
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The effects of co-existing acridine on adsorption-desorption behavior of carbazole in soils: Co-sorption and mechanism insight J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-03 Xueqi Zhang, Jianwei Li, Mengting Li, Wei Zhang, Yuting Wang, Qiming Xian
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Multi-pathways-mediated mechanisms of selenite reduction and elemental selenium nanoparticles biogenesis in the yeast-like fungus Aureobasidium melanogenum I15 J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-03 Si-Jia Xue, Xin-Tong Zhang, Xiao-Chen Li, Fang-Yuan Zhao, Xian Shu, Wen-Wen Jiang, Jin-Yong Zhang
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Multiplexed colorimetry collaborated with smartphone-based image analysis for simultaneous and fast visualization of dyes in both environmental and food samples J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-03 Shuangshou Wang, Yuwen Ding, Lu Zhang, Wenhao Yang, Tianyou Geng, Tong Li, Tingxuan Yan, Yang Chen, Tao Ma, Yu Wu, Jin Ye, Daojin Li
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Mitochondria‐associated endoplasmic reticulum membranes involve in oxidative stress‐induced intestinal barrier injury and mitochondrial dysfunction under diquat exposing Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-03 Feiyang Gou, Fengzhou Cai, Xin Li, Qian Lin, Jiang Zhu, Minjie Yu, Shaokui Chen, Jianjun Lu, Caihong Hu
Many factors induced by environmental toxicants have made oxidative stress a risk factor for the intestinal barrier injury and growth restriction, which is serious health threat for human and livestock and induces significant economic loss. It is well‐known that diquat‐induced oxidative stress is implicated in the intestinal barrier injury. Although some studies have shown that mitochondria are the
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Ketamine induces insomnia‐like symptom of zebrafish at environmentally relevant concentrations by mediating GABAergic synapse Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-03 Tingting Guo, Yuhang He, Shengqiang Mao, Ying Yang, Hongguan Xie, Sifan Zhang, Shuiping Dai
Although the stimulative effects on the normal behaviors of fish posed by ketamine (KET) were well‐studied, the adverse effects on the behavioral functions induced by KET at nighttime were unknown. Here, we used zebrafish larvae as a model exposed to KET (10, 50, 100, and 250 ng/L) at environmental levels for 21 days. The behavioral functions at nighttime, morphological changes during exposure stage
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Asiatic acid inhibits osteosarcoma cell migration and invasion via the AKT/Sp1/MMP1 axis Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-03 Yat‐Yin Law, Hsiang‐Lin Lee, Chu‐Liang Lin, Pei‐Ni Chen, Pei‐Han Wang, Yi‐Hsien Hsieh, Chien‐Min Chen
Osteosarcoma is a malignant bone tumor affecting adolescents and children. No effective treatment is currently available. Asiatic acid (AA), a triterpenoid compound found in Centella asiatica, possesses anti‐tumor, anti‐inflammatory, and anti‐oxidant properties in various types of tumor cells. This study aims to determine whether AA exerts antitumor effects in human osteosarcoma cells. Our results
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Correction to “The protective activity of nanomicelle curcumin in bisphenol A‐induced cardiotoxicity following subacute exposure in rats.” Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-03
Valokola MG, Karimi G, Razavi BM, et al. The protective activity of nanomicelle curcumin in bisphenol A-induced cardiotoxicity following subacute exposure in rats. Environ Toxicol. 2019; 34: 319–329. https://doi.org/10.1002/tox.22687 In paragraph 2 of the “Materials and Methods” section, the text, “Each group consisted of 6 rats.” was incorrect. This should have read: “Each group consisted of 4-8 rats
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Elucidating the role of FOS in modulating the immune microenvironment through fibroblast and myeloid cell regulation in locoregional recurrent HNSCC Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-03 Shaokun Liu, Boxuan Han, Ru Wang, Jugao Fang
BackgroundHead and neck squamous cell carcinoma (HNSCC) presents a significant clinical challenge, particularly due to its high propensity for locoregional recurrence. Current research underscores the need to unravel the complex interactions within the tumor microenvironment. This study addresses the critical gap in understanding how FOS modulates the immune landscape in HNSCC, with a focus on its
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Nationwide occurrence and discharge mass load of per- and polyfluoroalkyl substances in effluent and biosolids: A snapshot from 75 wastewater treatment plants across Australia J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-02 Hue T. Nguyen, Phong K. Thai, Sarit L. Kaserzon, Jake W. O'Brien, Jochen F. Mueller
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Emerging threat: Antimicrobial resistance proliferation during epidemics — A case study of the SARS-CoV-2 pandemic in South Brazil J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-02 Raizza Zorman Marques, Keite da Silva Nogueira, Ana Paula de Oliveira Tomaz, Philippe Juneau, Shanquan Wang, Marcelo Pedrosa Gomes
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Persistent pollution of genetic materials in a typical laboratory environment J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-02 Xue Li, Ce Liu, Dongbin Wang, Jianguo Deng, Yuntao Guo, Yicheng Shen, Shuwen Yang, John S. Ji, Haiyun Luo, Jingwei Bai, Jingkun Jiang
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Bioreduction of chromate in a syngas-based membrane biofilm reactor J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-02 Chenkai Niu, Xinyu Zhao, Danting Shi, Yifeng Ying, Mengxiong Wu, Chun-Yu Lai, Jianhua Guo, Shihu Hu, Tao Liu
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Novel insights into the kinetics and mechanism of arsenopyrite bio-dissolution enhanced by pyrite J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-02 Duo-Rui Zhang, Rui-Yong Zhang, Xue-Tai Zhu, Wei-Bao Kong, Chun Cao, Lei Zheng, Eva Pakostova
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Advancing microplastic surveillance through photoacoustic imaging and deep learning techniques J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-02 Mengyuan Huang, Kaitai Han, Wu Liu, Zijun Wang, Xi Liu, Qianjin Guo
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Light-induced degradation of dimethylmercury in different natural waters J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-02 Yingying Chen, Qingzhe Zhang, Lian Zhang, Xinning Liu, Yanwei Li, Runzeng Liu, Yingjun Wang, Yue Song, Yanbin Li, Yongguang Yin, Yong Cai
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Melatonin promotes cell cycle progression of neural stem cells subjected to manganese via Nurr1 Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-02 Nan Chen, Han Zhou, Bin He, Sen Peng, Feng Ding, Qi‐Hao Liu, Zhuo Ma, Wei Liu, Bin Xu
Excessive exposure to manganese (Mn) through drinking water and food during pregnancy significantly heightens the likelihood of neurodevelopmental damage in offspring. Multiple studies have indicated that melatonin (Mel) may help to relieve neurodevelopmental disorders caused by Mn, but potential mechanisms underlying this effect require further exploration. Here, we utilized primary neural stem cells
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Development of gene panel for predicting recurrence in early‐stage cervical cancer patients Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-02 Yun Ma, Weipei Zhu
Cervical cancer (CC) is a common malignancy affecting women worldwide. Our objective was to develop a consensus‐based gene panel using multi‐omics data that could effectively predict recurrence in early‐stage cervical cancer patients. We utilized the “Multi‐Omics Consensus Integration Analysis (MOVICS)” package for consensus clustering design to integrate multiple omics datasets and improve the molecular
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Quantitative and rapid detection of nanoplastics labeled by luminescent metal phenolic networks using surface-enhanced Raman scattering J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-01 Haoxin Ye, Ehsan Banayan Esfahani, Ivy Chiu, Madjid Mohseni, Guang Gao, Tianxi Yang
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Both nanoplastic and iron mineral types determine their heteroaggregation: Aggregation kinetics and interface process J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-01 Ning Liu, Yu Kong, Xuesong Cao, Le Yue, Zhenyu Wang, Xiaona Li
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An aberration-free line scan confocal Raman imager and type classification and distribution detection of microplastics J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-01 Changwei Jiao, Jiaqi Liao, Sailing He
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Phthalate acid esters: A review of aquatic environmental occurrence and their interactions with plants J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-01 Jiefeng Liang, Xiaomeng Ji, Xiaoxia Feng, Pinjie Su, Wenzhuo Xu, Qingzhe Zhang, Zhihua Ren, Yiling Li, Qingqing Zhu, Guangbo Qu, Runzeng Liu
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A powerful method for In Situ and rapid detection of trace nanoplastics in water—Mie scattering J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-01 Lei Mou, Qinzhou Zhang, Ruilong Li, Yaxian Zhu, Yong Zhang
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Organic photoelectrochemical transistor aptasensor for dual-mode detection of DEHP with CRISPR-Cas13a assisted signal amplification J. Hazard. Mater. (IF 13.6) Pub Date : 2024-04-01 Haowei Zhang, Miao Zhang, Yunlei Zhou, Zhen Qiao, Lanlan Gao, Lulu Cao, Huanshun Yin, Minghui Wang
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Sensitivity of cholinesterases and carboxylesterases to pharmaceutical products in Tinca tinca Environ. Toxicol. (IF 4.5) Pub Date : 2024-04-01 Ana‐Lourdes Oropesa, Blanca González‐Sánchez, Fernando J. Beltrán
Discharges to the aquatic environment of pharmaceuticals represent a hazard to the aquatic organisms. Subchronic assay with 17‐alpha‐ethinylestradiol (EE2) and in vitro essays with pharmaceuticals of environmental concern were conducted to examine the sensitivity of tissue acetylcholinesterase (AChE) and carboxylesterase (CbE) activities of Tinca tinca to them. Subchronic exposure to 17‐alpha‐EE2 caused