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Sweet regulation – The emerging immunoregulatory roles of hexoses J. Adv. Res. (IF 10.7) Pub Date : 2024-04-15 Junjie Xu, Yuening Zhao, Randall Tyler Mertens, Yimin Ding, Peng Xiao
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CircHIPK3 targets DRP1 to mediate hydrogen peroxide-induced necroptosis of vascular smooth muscle cells and atherosclerotic vulnerable plaque formation J. Adv. Res. (IF 10.7) Pub Date : 2024-04-15 Xiaolu Li, Yanyan Yang, Zhibin Wang, Xiaotong Lin, Xiuxiu Fu, Xiangqin He, Meixin Liu, Jian-Xun Wang, Tao Yu, Pin Sun
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FGF21 ameliorates septic liver injury by restraining proinflammatory macrophages activation through the autophagy/HIF-1α axis J. Adv. Res. (IF 10.7) Pub Date : 2024-04-09 Junjie Zhu, Zhouxiang Jin, Jie Wang, Zhaohang Wu, Tianpeng Xu, Gaozan Tong, Enzhao Shen, Junfu Fan, Chunhui Jiang, Jiaqi Wang, Xiaokun Li, Weitao Cong, Li Lin
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Ginger exosome-like nanoparticle-derived miRNA therapeutics: A strategic inhibitor of intestinal inflammation J. Adv. Res. (IF 10.7) Pub Date : 2024-04-06 Ling Yan, Yaqi Cao, Linhai Hou, Tianyu Luo, Meiqi Li, Shengjie Gao, Lei Wang, Kangliang Sheng, Lei Zheng
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Sedanolide alleviates DSS-induced colitis by modulating the intestinal FXR-SMPD3 pathway in mice J. Adv. Res. (IF 10.7) Pub Date : 2024-04-04 Shengjie Li, Aoxiang Zhuge, Hui Chen, Shengyi Han, Jian Shen, Kaicen Wang, Jiafeng Xia, He Xia, Shiman Jiang, Youhe Wu, Lanjuan Li
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Advances in molecular mechanisms and therapeutic strategies for central nervous system diseases based on gut microbiota imbalance J. Adv. Res. (IF 10.7) Pub Date : 2024-04-03 Wei Tao, Yanren Zhang, Bingbin Wang, Saiqun Nie, Li Fang, Jian Xiao, Yanqing Wu
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Understanding multicomponent low molecular weight gels from gelators to networks J. Adv. Res. (IF 10.7) Pub Date : 2024-04-01 Liangchun Li, Renlin Zheng, Rongqin Sun
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Exercise-Induced Reduction of IGF1R Sumoylation Attenuates Neuroinflammation in APP/PS1 Transgenic Mice J. Adv. Res. (IF 10.7) Pub Date : 2024-03-31 Yisheng Chen, Xiaofeng Chen, Zhiwen Luo, Xueran Kang, Yunshen Ge, Renwen Wan, Qian Wang, Zhihua Han, Fangqi Li, Zhongcheng Fan, Yuchun Xie, Beijie Qi, Xintao Zhang, Zhenwei Yang, John H Zhang, Danping Liu, Yuzhen Xu, Dongyan Wu, Shiyi Chen
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Low-frequency magnetic field therapy for glioblastoma: Current advances, mechanisms, challenges and future perspectives J. Adv. Res. (IF 10.7) Pub Date : 2024-03-31 Yinlong Liu, Qisheng Tang, Quan Tao, Hui Dong, Zhifeng Shi, Liangfu Zhou
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Comprehensive insights into potential roles of purinergic P2 receptors on diseases: Signaling pathways involved and potential therapeutics J. Adv. Res. (IF 10.7) Pub Date : 2024-03-31 Yanshuo Guo, Tianqi Mao, Yafei Fang, Hui Wang, Jiayue Yu, Yifan Zhu, Shige Shen, Mengze Zhou, Huanqiu Li, Qinghua Hu
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Erianin serves as an NFATc1 inhibitor to prevent breast cancer-induced osteoclastogenesis and bone destruction J. Adv. Res. (IF 10.7) Pub Date : 2024-03-30 Jiehuang Zheng, Weili He, Yan Chen, Lihong Li, Qinghe Liang, Wenqi Dai, Ruopeng Li, Fengsheng Chen, Ziye Chen, Yanhui Tan, Xiaojuan Li
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PPARs in atherosclerosis: The spatial and temporal features from mechanism to druggable targets J. Adv. Res. (IF 10.7) Pub Date : 2024-03-29 Yi Zheng, Mingyan Shao, Yanfei Zheng, Wenlong Sun, Si Qin, Ziwei Sun, Linghui Zhu, Yuanyuan Guan, Qi Wang, Yong Wang, Lingru Li
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Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome J. Adv. Res. (IF 10.7) Pub Date : 2024-03-27 Po-Jen Chen, Shun-Hua Chen, Yu-Li Chen, Yi-Hsuan Wang, Cheng-Yu Lin, Chun-Hong Chen, Yung-Fong Tsai, Tsong-Long Hwang
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Decoding and reconstructing disease relations between dry eye and depression: a multimodal investigation comprising meta-analysis, genetic pathways and Mendelian randomization J. Adv. Res. (IF 10.7) Pub Date : 2024-03-27 Kao-Jung Chang, Hsin-Yu Wu, Pin-Hsuan Chiang, Yu-Tien Hsu, Pei-Yu Weng, Ting-Han Yu, Cheng-Yi Li, Yu-Hsiang Chen, He-Jhen Dai, Han-Ying Tsai, Yu-Jung Chang, You-Ren Wu, Yi-Ping Yang, Cheng-Ta Li, Chih-Chien Hsu, Shih-Jen Chen, Yu-Chun Chen, Ching-Yu Cheng, Ai-Ru Hsieh, Shih-Hwa Chiou
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Long-term and short-term cardiovascular disease mortality among patients of 21 non-metastatic cancers J. Adv. Res. (IF 10.7) Pub Date : 2024-03-26 Tianwang Guan, Olivia Monteiro, Dongting Chen, Zehao Luo, Kaiyi Chi, Zhihao Li, Yinglan Liang, Zhenxing Lu, Yanting Jiang, Jinming Yang, Wenrui Lin, Min Yi, Kang Zhang, Caiwen Ou
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Multiplexed PLGA scaffolds with nitric oxide-releasing zinc oxide and melatonin-modulated extracellular vesicles for severe chronic kidney disease J. Adv. Res. (IF 10.7) Pub Date : 2024-03-25 Won-Kyu Rhim, Jiwon Woo, Jun Yong Kim, Eun Hye Lee, Seung-Gyu Cha, Da-Seul Kim, Seung-Woon Baek, Chun Gwon Park, Bum Soo Kim, Tae Gyun Kwon, Dong Keun Han
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Rapid discrimination and ratio quantification of mixed antibiotics in aqueous solution through integrative analysis of SERS spectra via CNN combined with NN-EN model J. Adv. Res. (IF 10.7) Pub Date : 2024-03-24 Quan Yuan, Lin-Fei Yao, Jia-Wei Tang, Zhang-Wen Ma, Jing-Yi Mou, Xin-Ru Wen, Muhammad Usman, Xiang Wu, Liang Wang
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Kurarinone regulates Th17/Treg balance and ameliorates autoimmune uveitis via Rac1 inhibition J. Adv. Res. (IF 10.7) Pub Date : 2024-03-24 Chenyang Gu, Yidan Liu, Jianjie Lv, Chun Zhang, Zhaohao Huang, Qi Jiang, Yuehan Gao, Tianyu Tao, Yuhan Su, Binyao Chen, Renbing Jia, Xiuxing Liu, Wenru Su
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The J bs-5YP peptide can alleviate dementia in senile mice by restoring the transcription of Slc40a1 to secrete the excessive iron from brain J. Adv. Res. (IF 10.7) Pub Date : 2024-03-23 Zhenyou Zou, Fengyao Wu, Liguan Chen, Hua Yao, Zengxian Wang, Yongfeng Chen, Ming Qi, Yang Jiang, Longhua Tang, Xinying Gan, Lingjia Kong, Zhicheng Yang, Xiaolan Huang, Wei Shu, Bixue Li, Xinyu Tan, Liwen Huang, Shi Bai, Lijuan Wu, Jinping Mo, Huilin Hu, Huihua Liu, Ruyi Zou, Yuhua Wei
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Preparation of human astrocytes with potent therapeutic functions from human pluripotent stem cells using ventral midbrain patterning J. Adv. Res. (IF 10.7) Pub Date : 2024-03-22 Ye Rim Nam, Minji Kang, Minji Kim, Min Jong Seok, Yunseon Yang, Young Eun Han, Soo-Jin Oh, Do Gyeong Kim, Hyeon Son, Mi-Yoon Chang, Sang-Hun Lee
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Extracellular vesicles derived from Lactobacillus johnsonii promote gut barrier homeostasis by enhancing M2 macrophage polarization J. Adv. Res. (IF 10.7) Pub Date : 2024-03-18 Shiyu Tao, Jinping Fan, Jingjing Li, Zhifeng Wu, Yong Yao, Zhenyu Wang, Yujun Wu, Xiangdong Liu, Yingping Xiao, Hong Wei
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The efferocytosis process in aging: Supporting evidence, mechanisms, and therapeutic prospects for age-related diseases J. Adv. Res. (IF 10.7) Pub Date : 2024-03-17 Meng Zhang, Jin Wei, Yu Sun, Chang He, Shiyin Ma, Xudong Pan, Xiaoyan Zhu
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Efficient chemo-immunotherapy leveraging minimalist electrostatic complex nanoparticle as “in situ” vaccine integrated tumor ICD and immunoagonist J. Adv. Res. (IF 10.7) Pub Date : 2024-03-16 Yunfei Han, Mingxia Jiang, Yanju Sun, Wenqiang Chen, Yanli Zhao, Xiuwen Guan, Weifen Zhang
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The role of extracellular vesicles in non-alcoholic steatohepatitis: Emerging mechanisms, potential therapeutics and biomarkers J. Adv. Res. (IF 10.7) Pub Date : 2024-03-15 Qianrong Wang, Xiangning Tang, Yu Wang, Danyi Zhang, Xia Li, Shanshan Liu
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Nuclear transport of phosphorylated LanCL2 promotes invadopodia formation and tumor progression of glioblastoma by activating STAT3/Cortactin signaling J. Adv. Res. (IF 10.7) Pub Date : 2024-03-15 Hua-fu Zhao, Yun-sheng Liu, Jing Wang, Chang-peng Wu, Xiu-ming Zhou, Lin-rong Cai, Jing Liu, Xiao-jia Liu, Yan-wen Xu, Wei-ping Li, Guo-dong Huang
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Sonic hedgehog restrains the ubiquitin-dependent degradation of SP1 to inhibit neuronal/glial senescence associated phenotypes in chemotherapy-induced peripheral neuropathy via the TRIM25-CXCL13 axis J. Adv. Res. (IF 10.7) Pub Date : 2024-03-12 Ying Zou, Shu Wu, Qian Hu, Haoxian Zhou, Yuanlong Ge, Zhenyu Ju, Shengkang Luo
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Polyphenols synergistic drugs to ameliorate non-alcoholic fatty liver disease via signal pathway and gut microbiota: A review J. Adv. Res. (IF 10.7) Pub Date : 2024-03-11 Hongcai Li, Jingjing Liang, Mengzhen Han, Zhenpeng Gao
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Hybridization-based discovery of novel quinazoline-2-indolinone derivatives as potent and selective PI3Kα inhibitors J. Adv. Res. (IF 10.7) Pub Date : 2024-03-11 Changqun Liu, Yuening Cao, Yi Zuo, Chaozheng Zhang, Senmiao Ren, Xin Zhang, Chuanqi Wang, Yingjie Zeng, Jie Ling, Yilan Liu, Zixian Chen, Xiujun Cao, Zhengzhi Wu, Chuantao Zhang, Jun Lu
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Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms J. Adv. Res. (IF 10.7) Pub Date : 2024-03-09 Yue Xiao, Yingxuan Feng, Jianxin Zhao, Wei Chen, Wenwei Lu
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Gut microbiome-derived bacterial extracellular vesicles in patients with solid tumours J. Adv. Res. (IF 10.7) Pub Date : 2024-03-07 Surbhi Mishra, Mysore Vishakantegowda Tejesvi, Jenni Hekkala, Jenni Turunen, Niyati Kandikanti, Anna Kaisanlahti, Marko Suokas, Sirpa Leppä, Pia Vihinen, Hanne Kuitunen, Kaisa Sunela, Jussi Koivunen, Arja Jukkola, Ilja Kalashnikov, Päivi Auvinen, Okko-Sakari Kääriäinen, T. Peñate Medina, O. Peñate Medina, Juha Saarnio, Sanna Meriläinen, Tero Rautio, Raila Aro, Reetta Häivälä, Juho Suojanen, Mikael
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The epidermal lipid-microbiome loop and immunity: Important players in atopic dermatitis J. Adv. Res. (IF 10.7) Pub Date : 2024-03-07 Junchao Wu, Lisha Li, Tingrui Zhang, Jiaye Lu, Zongguang Tai, Quangang Zhu, Zhongjian Chen
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Unlocking melanoma Suppression: Insights from Plasma-Induced potent miRNAs through PI3K-AKT-ZEB1 axis J. Adv. Res. (IF 10.7) Pub Date : 2024-03-04 Pradeep Bhartiya, Apurva Jaiswal, Manorma Negi, Neha Kaushik, Eun Ha Choi, Nagendra Kumar Kaushik
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Metformin blocks BIK1-mediated CPK28 phosphorylation and enhances plant immunity J. Adv. Res. (IF 10.7) Pub Date : 2024-03-03 Yazhou Bao, Qian Zhang, Hai Zhu, Yong Pei, Yaning Zhao, Yixin Li, Peiyun Ji, Dandan Du, Hao Peng, Guangyuan Xu, Xiaodan Wang, Zhiyuan Yin, Gan Ai, Xiangxiu Liang, Daolong Dou
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NCAPD3 promotes diffuse large B-cell lymphoma progression through modulating SIRT1 expression in an H3K9 monomethylation-dependent manner J. Adv. Res. (IF 10.7) Pub Date : 2024-03-02 Tiange Lu, Juan Yang, Yiqing Cai, Mengfei Ding, Zhuoya Yu, Xiaosheng Fang, Xiangxiang Zhou, Xin Wang
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Baicalein induces apoptosis by inhibiting the glutamine-mTOR metabolic pathway in lung cancer J. Adv. Res. (IF 10.7) Pub Date : 2024-03-02 Jingyang Li, Di Zhang, Shaohui Wang, Peng Yu, Jiayi Sun, Yi Zhang, Xianli Meng, Juan Li, Li Xiang
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Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway J. Adv. Res. (IF 10.7) Pub Date : 2024-03-02 Tingting Zhang, Mengmeng Zhu, Jialing Ma, Zhenghong Liu, Zhidan Zhang, Meijie Chen, Yaping Zhao, Huaxin Li, Shengnan Wang, Xiaoning Wei, Wenwen Zhang, Xiaoxiao Yang, Peter J. Little, Danielle Kamato, Hao Hu, Yajun Duan, Baotong Zhang, Jianbo Xiao, Suowen Xu, Yuanli Chen
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Machine learning and genetic algorithm-guided directed evolution for the development of antimicrobial peptides J. Adv. Res. (IF 10.7) Pub Date : 2024-03-01 Heqian Zhang, Yihan Wang, Yanran Zhu, Pengtao Huang, Qiandi Gao, Xiaojie Li, Zhaoying Chen, Yu Liu, Jiakun Jiang, Yuan Gao, Jiaquan Huang, Zhiwei Qin
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Salidroside promotes pro-angiogenesis and repair of blood brain barrier via Notch/ITGB1 signal path in CSVD Model J. Adv. Res. (IF 10.7) Pub Date : 2024-02-28 Tu Zhilan, Zhang Zengyu, Jin Pengpeng, Yang Hualan, Li Chao, Xi Yan, Guo Zimin, Hou Shuangxing, Li Weiwei
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MCU complex: Exploring emerging targets and mechanisms of mitochondrial physiology and pathology J. Adv. Res. (IF 10.7) Pub Date : 2024-02-27 Jin Wang, Jinyong Jiang, Haoliang Hu, Linxi Chen
The integral roles of the MCU complex in pathophysiological processes, and the relationship between agonists, inhibitors, and traditional Chinese medicine monomers related to the MCU complex.
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Exploring the impacts of senescence on implantation and early embryonic development using totipotent cell-derived blastoids J. Adv. Res. (IF 10.7) Pub Date : 2024-02-24 Yuxin Luo, Chenrui An, Ke Zhong, Ping Zhou, Dan Li, Hui Liu, Qing Guo, Wei Wei, Hen Pan, Zheying Min, Rong Li, Yang Yu, Yong Fan
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AdipoRon ameliorates the progression of heart failure with preserved ejection fraction via mitigating lipid accumulation and fibrosis J. Adv. Res. (IF 10.7) Pub Date : 2024-02-20 Wuping Tan, Yijun Wang, Siyi Cheng, Zhihao Liu, Mengjie Xie, Lingpeng Song, Qinfang Qiu, Xiaofei Wang, Zeyan Li, Tianyuan Liu, Fuding Guo, Jun Wang, Xiaoya Zhou
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Melatonin alleviates high temperature exposure induced fetal growth restriction via the gut-placenta-fetus axis in pregnant mice J. Adv. Res. (IF 10.7) Pub Date : 2024-02-20 Jia-Jin Wu, Xiaoyu Zheng, Caichi Wu, Wen Ma, Yibo Wang, Jun Wang, Yulong Wei, Xiangfang Zeng, Shihai Zhang, Wutai Guan, Fang Chen
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Targeting lipid metabolism of macrophages: A new strategy for tumor therapy J. Adv. Res. (IF 10.7) Pub Date : 2024-02-18 Nan Shao, Hui Qiu, Jing Liu, Daimin Xiao, Juanjuan Zhao, Chao Chen, Jiajia Wan, Mengmeng Guo, Guiyou Liang, Xu Zhao, Lin Xu
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A narrative review about cognitive impairment in metabolic Dysfunction–Associated liver disease (MASLD): Another matter to face through a holistic approach J. Adv. Res. (IF 10.7) Pub Date : 2024-02-17 Marica Meroni, Miriam Longo, Erika Paolini, Paola Dongiovanni
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The BET inhibitor JQ1 targets fat metabolism and counteracts obesity J. Adv. Res. (IF 10.7) Pub Date : 2024-02-15 Claudia Fornelli, Alessia Sofia Cento, Lorenzo Nevi, Raffaella Mastrocola, Gustavo Ferreira Alves, Giuseppina Caretti, Massimo Collino, Fabio Penna
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Recent advances in integrated solar cell/supercapacitor devices: Fabrication, strategy and perspectives J. Adv. Res. (IF 10.7) Pub Date : 2024-02-13 Qiaoling Zhang, Guodong Li, Fen Qiao
From the microscopic mechanism of different functional unit materials to the energy conversion and storage mechanism of macroscopic integrated devices, the design of highly efficient and stable integrated SCSD, the law of improving solar energy conversion and storage performance by supercapacitors and solar cell stacks were systematically discussed.
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Single-cell transcriptomic profiling of heart reveals ANGPTL4 linking fibroblasts and angiogenesis in heart failure with preserved ejection fraction J. Adv. Res. (IF 10.7) Pub Date : 2024-02-11 Guoxing Li, Huilin Zhao, Zhe Cheng, Junjin Liu, Gang Li, Yongzheng Guo
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DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD J. Adv. Res. (IF 10.7) Pub Date : 2024-02-10 Yuan Zhan, Qian Huang, Zhesong Deng, Shanshan Chen, Ruonan Yang, Jiaheng Zhang, Yating Zhang, Maocuo Peng, Jixing Wu, Yiya Gu, Zhilin Zeng, Jungang Xie
Cigarette smoke decreases DNA methylation level of GADD45B promoter in bronchial epithelial cell, thereby promotes GADD45B expression. Subsequently, GADD45B upregulation can directly promote release of inflammatory cytokines through phosphorylation of p38, and can also promote cell senescence by interacting with FOS, which furtherly aggravates inflammation via phosphorylating p38.
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High SERS performance of functionalized carbon dots in the detection of dye contaminants J. Adv. Res. (IF 10.7) Pub Date : 2024-02-09 Yanqiu Yang, Lingru Kong, Yong Ding, Lixin Xia, Shuo Cao, Peng Song
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Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel disease J. Adv. Res. (IF 10.7) Pub Date : 2024-02-09 Jinling Li, Ting Luo, Dou Wang, Yao Zhao, Yuanxiang Jin, Guiling Yang, Xin Zhang
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New molecular mechanisms to explain the neuroprotective effects of insulin-like growth factor II in a cellular model of Parkinson’s disease J. Adv. Res. (IF 10.7) Pub Date : 2024-02-08 Silvana-Yanina Romero-Zerbo, Nadia Valverde, Silvia Claros, Pablo Zamorano-Gonzalez, Federica Boraldi, Francesco-Demetrio Lofaro, Estrella Lara, Jose Pavia, Maria Garcia-Fernandez, Belen Gago, Elisa Martin-Montañez
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Collecting duct NCOR1 controls blood pressure by regulating mineralocorticoid receptor J. Adv. Res. (IF 10.7) Pub Date : 2024-02-08 Ke Sun, Yong-Li Wang, Chen-Chen Hou, Da Shang, Lin-Juan Du, Lan Bai, Xing-Yu Zhang, Chuan-Ming Hao, Sheng-Zhong Duan
Schematic illustration of NCOR1 function in collecting duct cells. Collecting duct NCOR1 is involved in BP regulation by interacting with MR and then down-regulating the expression of ENaC genes. Spironolactone or amiloride treatment ameliorates the exacerbating effects of collecting duct NCOR1 deficiency on hypertension.
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Identification of a transcription factor AoMsn2 of the Hog1 signaling pathway contributes to fungal growth, development and pathogenicity in Arthrobotrys oligospora J. Adv. Res. (IF 10.7) Pub Date : 2024-02-07 Qianqian Liu, Kexin Jiang, Shipeng Duan, Na Zhao, Yanmei Shen, Lirong Zhu, Ke-Qin Zhang, Jinkui Yang
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The future of plant based green carbon dots as cancer Nanomedicine: From current progress to future Perspectives and beyond J. Adv. Res. (IF 10.7) Pub Date : 2024-02-05 Hong Hui Jing, Ali A. Shati, Mohammad Y. Alfaifi, Serag Eldin I. Elbehairi, Sreenivasan Sasidharan
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BPA and low-Se exacerbate apoptosis and mitophagy in chicken pancreatic cells by regulating the PTEN/PI3K/AKT/mTOR pathway J. Adv. Res. (IF 10.7) Pub Date : 2024-02-03 Wenying Sun, Yutian Lei, Zhihui Jiang, Kun Wang, Huanyi Liu, Tong Xu
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The role of transcription factors in the crosstalk between cancer-associated fibroblasts and tumor cells J. Adv. Res. (IF 10.7) Pub Date : 2024-02-02 Xiaoyan Zhang, Meng Zhang, Hui Sun, Xu Wang, Xin Wang, Weiqi Sheng, Midie Xu
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Glycosidic linkages of fungus polysaccharides influence the anti-inflammatory activity in mice J. Adv. Res. (IF 10.7) Pub Date : 2024-02-02 Qin Yuan, Wen Liu, Wei Hao, Yi Chen, Yaqin Xiao, Hongyi Li, Mingju Shui, Ding-Tao Wu, Shengpeng Wang
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Studying changes in the dynamical patterns in two physical models involving new Caputo operator J. Adv. Res. (IF 10.7) Pub Date : 2024-02-02 A.E. Matouk
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Mechanisms and therapeutic implications of selective autophagy in nonalcoholic fatty liver disease J. Adv. Res. (IF 10.7) Pub Date : 2024-02-01 Suwei Jin, Yujia Li, Tianji Xia, Yongguang Liu, Shanshan Zhang, Hongbo Hu, Qi Chang, Mingzhu Yan
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Cellular and physiological functions of SGR family in gravitropic response in higher plants J. Adv. Res. (IF 10.7) Pub Date : 2024-02-01 Yuhan Cho, Yujeong Kim, Hyebi Lee, Sundong Kim, Jaehee Kang, Ulhas S. Kadam, Soon Ju Park, Woo Sik Chung, Jong Chan Hong