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Bounds on the Ultrasensitivity of Biochemical Reaction Cascades Bull. Math. Biol. (IF 3.5) Pub Date : 2024-04-18 Marcello Pajoh-Casco, Abishek Vinujudson, German Enciso
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Integrating Diversity, Equity, and Inclusion into Preclinical, Clinical, and Public Health Mathematical Models Bull. Math. Biol. (IF 3.5) Pub Date : 2024-04-16 Justin Sheen, Lee Curtin, Stacey Finley, Anna Konstorum, Reginald McGee, Morgan Craig
Mathematical modelling applied to preclinical, clinical, and public health research is critical for our understanding of a multitude of biological principles. Biology is fundamentally heterogeneous, and mathematical modelling must meet the challenge of variability head on to ensure the principles of diversity, equity, and inclusion (DEI) are integrated into quantitative analyses. Here we provide a
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A Mathematical Model of TCR-T Cell Therapy for Cervical Cancer Bull. Math. Biol. (IF 3.5) Pub Date : 2024-04-16 Zuping Wang, Heyrim Cho, Peter Choyke, Doron Levy, Noriko Sato
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Minimal Mechanisms of Microtubule Length Regulation in Living Cells Bull. Math. Biol. (IF 3.5) Pub Date : 2024-04-16 Anna C. Nelson, Melissa M. Rolls, Maria-Veronica Ciocanel, Scott A. McKinley
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Understanding and Quantifying Network Robustness to Stochastic Inputs Bull. Math. Biol. (IF 3.5) Pub Date : 2024-04-12 Hwai-Ray Tung, Sean D. Lawley
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Mathematical Modelling of Parasite Dynamics: A Stochastic Simulation-Based Approach and Parameter Estimation via Modified Sequential-Type Approximate Bayesian Computation Bull. Math. Biol. (IF 3.5) Pub Date : 2024-04-10 Clement Twumasi, Joanne Cable, Andrey Pepelyshev
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Mathematical Models of Early Hepatitis B Virus Dynamics in Humanized Mice Bull. Math. Biol. (IF 3.5) Pub Date : 2024-04-09 Stanca M. Ciupe, Harel Dahari, Alexander Ploss
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Advice to a Young Mathematical Biologist Bull. Math. Biol. (IF 3.5) Pub Date : 2024-04-09 Paul A. Roberts
This paper offers advice to early-mid career researchers in Mathematical Biology from ten past and current Presidents of the Society for Mathematical Biology. The topics covered include deciding if a career in academia is right for you; finding and working with a mentor; building collaborations and working with those from other disciplines; formulating a research question; writing a paper; reviewing
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Dynamics of Information Flow and Task Allocation of Social Insect Colonies: Impacts of Spatial Interactions and Task Switching Bull. Math. Biol. (IF 3.5) Pub Date : 2024-04-06
Abstract Models of social interaction dynamics have been powerful tools for understanding the efficiency of information spread and the robustness of task allocation in social insect colonies. How workers spatially distribute within the colony, or spatial heterogeneity degree (SHD), plays a vital role in contact dynamics, influencing information spread and task allocation. We used agent-based models
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Optimal Rotation Age in Fast Growing Plantations: A Dynamical Optimization Problem Bull. Math. Biol. (IF 3.5) Pub Date : 2024-04-06
Abstract Forest plantations are economically and environmentally relevant, as they play a key role in timber production and carbon capture. It is expected that the future climate change scenario affects forest growth and modify the rotation age for timber production. However, mathematical models on the effect of climate change on the rotation age for timber production remain still limited. We aim to
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Artificial Neural Network Prediction of COVID-19 Daily Infection Count Bull. Math. Biol. (IF 3.5) Pub Date : 2024-04-01
Abstract This study addresses COVID-19 testing as a nonlinear sampling problem, aiming to uncover the dependence of the true infection count in the population on COVID-19 testing metrics such as testing volume and positivity rates. Employing an artificial neural network, we explore the relationship among daily confirmed case counts, testing data, population statistics, and the actual daily case count
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Combinatorial Cooperativity in miR200-Zeb Feedback Network can Control Epithelial–Mesenchymal Transition Bull. Math. Biol. (IF 3.5) Pub Date : 2024-03-30 Mubasher Rashid, Brasanna M. Devi, Malay Banerjee
Carcinomas often utilize epithelial-mesenchymal transition (EMT) programs for cancer progression and metastasis. Numerous studies report SNAIL-induced miR200/Zeb feedback circuit as crucial in regulating EMT by placing cancer cells in at least three phenotypic states, viz. epithelial (E), hybrid (h-E/M), mesenchymal (M), along the E-M phenotypic spectrum. However, a coherent molecular-level understanding
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Second-Order Effects of Chemotherapy Pharmacodynamics and Pharmacokinetics on Tumor Regression and Cachexia Bull. Math. Biol. (IF 3.5) Pub Date : 2024-03-28
Abstract Drug dose response curves are ubiquitous in cancer biology, but these curves are often used to measure differential response in first-order effects: the effectiveness of increasing the cumulative dose delivered. In contrast, second-order effects (the variance of drug dose) are often ignored. Knowledge of second-order effects may improve the design of chemotherapy scheduling protocols, leading
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Inferring Parameters of Pyramidal Neuron Excitability in Mouse Models of Alzheimer’s Disease Using Biophysical Modeling and Deep Learning Bull. Math. Biol. (IF 3.5) Pub Date : 2024-03-25 Soheil Saghafi, Timothy Rumbell, Viatcheslav Gurev, James Kozloski, Francesco Tamagnini, Kyle C. A. Wedgwood, Casey O. Diekman
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Enumeration of Rooted Binary Unlabeled Galled Trees Bull. Math. Biol. (IF 3.5) Pub Date : 2024-03-22 Lily Agranat-Tamir, Shaili Mathur, Noah A. Rosenberg
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NIAID/SMB Workshop on Multiscale Modeling of Infectious and Immune-Mediated Diseases Bull. Math. Biol. (IF 3.5) Pub Date : 2024-03-21
Abstract On July 19th, 2023, the National Institute of Allergy and Infectious Diseases co-organized a workshop with the Society of Mathematical Biology, with the authors of this paper as the organizing committee. The workshop, “Bridging multiscale modeling and practical clinical applications in infectious diseases” sought to create an environment for mathematical modelers, statisticians, and infectious
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Impact of Resistance on Therapeutic Design: A Moran Model of Cancer Growth Bull. Math. Biol. (IF 3.5) Pub Date : 2024-03-19 Mason S. Lacy, Adrianne L. Jenner
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Modeling of Mouse Experiments Suggests that Optimal Anti-Hormonal Treatment for Breast Cancer is Diet-Dependent Bull. Math. Biol. (IF 3.5) Pub Date : 2024-03-18 Tuğba Akman, Lisa M. Arendt, Jürgen Geisler, Vessela N. Kristensen, Arnoldo Frigessi, Alvaro Köhn-Luque
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$$R_0$$ May Not Tell Us Everything: Transient Disease Dynamics of Some SIR Models Over Patchy Environments Bull. Math. Biol. (IF 3.5) Pub Date : 2024-03-15 Ao Li, Xingfu Zou
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Nonlinear Regression Modelling: A Primer with Applications and Caveats Bull. Math. Biol. (IF 3.5) Pub Date : 2024-03-15
Abstract Use of nonlinear statistical methods and models are ubiquitous in scientific research. However, these methods may not be fully understood, and as demonstrated here, commonly-reported parameter p-values and confidence intervals may be inaccurate. The gentle introduction to nonlinear regression modelling and comprehensive illustrations given here provides applied researchers with the needed
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Discretised Flux Balance Analysis for Reaction–Diffusion Simulation of Single-Cell Metabolism Bull. Math. Biol. (IF 3.5) Pub Date : 2024-03-06 Yin Hoon Chew, Fabian Spill
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A Mathematical Model of Stroma-Supported Allometric Tumor Growth Bull. Math. Biol. (IF 3.5) Pub Date : 2024-03-06 Rachel Leander, Greg Owanga, David Nelson, Yeqian Liu
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Modelling the Effects of Growth and Remodelling on the Density and Structure of Cancellous Bone Bull. Math. Biol. (IF 3.5) Pub Date : 2024-03-04 Brianna L. Martin, Karen J. Reynolds, Nicola L. Fazzalari, Murk J. Bottema
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Parameter Identifiability in PDE Models of Fluorescence Recovery After Photobleaching Bull. Math. Biol. (IF 3.5) Pub Date : 2024-03-02 Maria-Veronica Ciocanel, Lee Ding, Lucas Mastromatteo, Sarah Reichheld, Sarah Cabral, Kimberly Mowry, Björn Sandstede
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First Passage Times of Long Transient Dynamics in Ecology Bull. Math. Biol. (IF 3.5) Pub Date : 2024-02-23 Grant R. Poulsen, Claire E. Plunkett, Jody R. Reimer
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3D Genome Reconstruction from Partially Phased Hi-C Data Bull. Math. Biol. (IF 3.5) Pub Date : 2024-02-22
Abstract The 3-dimensional (3D) structure of the genome is of significant importance for many cellular processes. In this paper, we study the problem of reconstructing the 3D structure of chromosomes from Hi-C data of diploid organisms, which poses additional challenges compared to the better-studied haploid setting. With the help of techniques from algebraic geometry, we prove that a small amount
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Order-of-Mutation Effects on Cancer Progression: Models for Myeloproliferative Neoplasm Bull. Math. Biol. (IF 3.5) Pub Date : 2024-02-16 Yue Wang, Blerta Shtylla, Tom Chou
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Impacts of Vaccination and Severe Acute Respiratory Syndrome Coronavirus 2 Variants Alpha and Delta on Coronavirus Disease 2019 Transmission Dynamics in Four Metropolitan Areas of the United States Bull. Math. Biol. (IF 3.5) Pub Date : 2024-02-14 Abhishek Mallela, Ye Chen, Yen Ting Lin, Ely F. Miller, Jacob Neumann, Zhili He, Kathryn E. Nelson, Richard G. Posner, William S. Hlavacek
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Optimal Control with RdCVFL for Degenerating Photoreceptors Bull. Math. Biol. (IF 3.5) Pub Date : 2024-02-12 Kathryn Wifvat, Erika T. Camacho, Matthias Kawski, Thierry Léveillard, Stephen Wirkus
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A Model for Membrane Degradation Using a Gelatin Invadopodia Assay Bull. Math. Biol. (IF 3.5) Pub Date : 2024-02-12 Giorgia Ciavolella, Nathalie Ferrand, Michéle Sabbah, Benoît Perthame, Roberto Natalini
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Distinguishing Between Long-Transient and Asymptotic States in a Biological Aggregation Model Bull. Math. Biol. (IF 3.5) Pub Date : 2024-02-11 Jonathan R. Potts, Kevin J. Painter
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Infectious Disease in the Workplace: Quantifying Uncertainty in Transmission Bull. Math. Biol. (IF 3.5) Pub Date : 2024-02-01 Jonathan I. D. Hamley, Guido Beldi, Daniel Sánchez-Taltavull
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A Generalized Kinetic Model of Fractional Order Transport Dynamics with Transit Time Heterogeneity in Microvascular Space Bull. Math. Biol. (IF 3.5) Pub Date : 2024-02-01 Stefan Hindel
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Ranked Subtree Prune and Regraft Bull. Math. Biol. (IF 3.5) Pub Date : 2024-01-31
Abstract Phylogenetic trees are a mathematical formalisation of evolutionary histories between organisms, species, genes, cancer cells, etc. For many applications, e.g. when analysing virus transmission trees or cancer evolution, (phylogenetic) time trees are of interest, where branch lengths represent times. Computational methods for reconstructing time trees from (typically molecular) sequence data
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Lyme Disease Models of Tick-Mouse Dynamics with Seasonal Variation in Births, Deaths, and Tick Feeding Bull. Math. Biol. (IF 3.5) Pub Date : 2024-01-31 Kateryna Husar, Dana C. Pittman, Johnny Rajala, Fahad Mostafa, Linda J. S. Allen
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Making Your Own Luck: Weak Vertical Swimming Improves Dispersal Success for Coastal Marine Larvae Bull. Math. Biol. (IF 3.5) Pub Date : 2024-01-28 Alexander D. Meyer, Alan Hastings, John L. Largier
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A Kinetic Finite Volume Discretization of the Multidimensional PIDE Model for Gene Regulatory Networks Bull. Math. Biol. (IF 3.5) Pub Date : 2024-01-22 Mihály A. Vághy, Irene Otero-Muras, Manuel Pájaro, Gábor Szederkényi
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Turing Instabilities are Not Enough to Ensure Pattern Formation Bull. Math. Biol. (IF 3.5) Pub Date : 2024-01-22 Andrew L. Krause, Eamonn A. Gaffney, Thomas Jun Jewell, Václav Klika, Benjamin J. Walker
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Understanding the Interplay of CAR-NK Cells and Triple-Negative Breast Cancer: Insights from Computational Modeling Bull. Math. Biol. (IF 3.5) Pub Date : 2024-01-19 Abazar Arabameri, Samaneh Arab
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A Countable-Type Branching Process Model for the Tug-of-War Cancer Cell Dynamics Bull. Math. Biol. (IF 3.5) Pub Date : 2024-01-18 Ren-Yi Wang, Marek Kimmel
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Predicting Radiotherapy Patient Outcomes with Real-Time Clinical Data Using Mathematical Modelling Bull. Math. Biol. (IF 3.5) Pub Date : 2024-01-18 Alexander P. Browning, Thomas D. Lewin, Ruth E. Baker, Philip K. Maini, Eduardo G. Moros, Jimmy Chaudell, Helen M. Byrne, Heiko Enderling
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Sexual Dimorphism in Substrate Metabolism During Exercise Bull. Math. Biol. (IF 3.5) Pub Date : 2024-01-16 Stéphanie M. C. Abo, Elisa Casella, Anita T. Layton
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Bat Motion can be Described by Leap Frogging Bull. Math. Biol. (IF 3.5) Pub Date : 2024-01-10 Lucy Henley, Owen Jones, Fiona Mathews, Thomas E. Woolley
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A Semi-Markov Approach to Study a Group of Kinesin Motors Bull. Math. Biol. (IF 3.5) Pub Date : 2024-01-06 Lifeng Han, John Fricks
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Turing Pattern Formation in Reaction-Cross-Diffusion Systems with a Bilayer Geometry Bull. Math. Biol. (IF 3.5) Pub Date : 2024-01-03 Antoine Diez, Andrew L. Krause, Philip K. Maini, Eamonn A. Gaffney, Sungrim Seirin-Lee
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Dynamics of Lotka–Volterra Competition Patch Models in Streams with Two Branches Bull. Math. Biol. (IF 3.5) Pub Date : 2024-01-05 Weiwei Liu, Jie Liu, Shanshan Chen
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Local Identifiability Analysis, Parameter Subset Selection and Verification for a Minimal Brain PBPK Model Bull. Math. Biol. (IF 3.5) Pub Date : 2024-01-03 Kamala Dadashova, Ralph C. Smith, Mansoor A. Haider
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Connecting Agent-Based Models with High-Dimensional Parameter Spaces to Multidimensional Data Using SMoRe ParS: A Surrogate Modeling Approach Bull. Math. Biol. (IF 3.5) Pub Date : 2023-12-30 Daniel R. Bergman, Kerri-Ann Norton, Harsh Vardhan Jain, Trachette Jackson
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Generation of Orchard and Tree-Child Networks Bull. Math. Biol. (IF 3.5) Pub Date : 2023-12-20 Gabriel Cardona, Gerard Ribas, Joan Carles Pons
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Dynamics of a Mosquito Egg-Larvae Model with Seasonality Bull. Math. Biol. (IF 3.5) Pub Date : 2023-12-18 Jesús Bellver-Arnau, Alessandro Margheri, Carlota Rebelo
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Formation and Growth of Co-Culture Tumour Spheroids: New Compartment-Based Mathematical Models and Experiments Bull. Math. Biol. (IF 3.5) Pub Date : 2023-12-13 Ryan J. Murphy, Gency Gunasingh, Nikolas K. Haass, Matthew J. Simpson
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Models for Implant-Induced Capsular Contracture Post Breast Cancer Surgery Bull. Math. Biol. (IF 3.5) Pub Date : 2023-12-13 Cheryl Dyck, Kathryn V. Isaac, Leah Edelstein-Keshet
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Towards Inferring Network Properties from Epidemic Data Bull. Math. Biol. (IF 3.5) Pub Date : 2023-12-08 Istvan Z. Kiss, Luc Berthouze, Wasiur R. KhudaBukhsh
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Information-Theoretic Analysis of a Model of CAR-4-1BB-Mediated NFκB Activation Bull. Math. Biol. (IF 3.5) Pub Date : 2023-12-01 Vardges Tserunyan, Stacey Finley
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Novel Aspects in Pattern Formation Arise from Coupling Turing Reaction–Diffusion and Chemotaxis Bull. Math. Biol. (IF 3.5) Pub Date : 2023-12-01 Camile Fraga Delfino Kunz, Alf Gerisch, James Glover, Denis Headon, Kevin John Painter, Franziska Matthäus
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Pattern Formation in Mesic Savannas Bull. Math. Biol. (IF 3.5) Pub Date : 2023-11-27 Denis Patterson, Simon Levin, Ann Carla Staver, Jonathan Touboul
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Empirical Quantification of Predictive Uncertainty Due to Model Discrepancy by Training with an Ensemble of Experimental Designs: An Application to Ion Channel Kinetics Bull. Math. Biol. (IF 3.5) Pub Date : 2023-11-24 Joseph G. Shuttleworth, Chon Lok Lei, Dominic G. Whittaker, Monique J. Windley, Adam P. Hill, Simon P. Preston, Gary R. Mirams
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Optimizing Antimicrobial Treatment Schedules: Some Fundamental Analytical Results Bull. Math. Biol. (IF 3.5) Pub Date : 2023-11-23 Guy Katriel
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Temporary Cross-Immunity as a Plausible Driver of Asynchronous Cycles of Dengue Serotypes Bull. Math. Biol. (IF 3.5) Pub Date : 2023-11-14 Tak Fung, Hannah E. Clapham, Ryan A. Chisholm
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Optimization Therapy by Coupling Intermittent Androgen Suppression with Impulsive Chemotherapy for a Prostate Cancer Model Bull. Math. Biol. (IF 3.5) Pub Date : 2023-11-07 Yongzhen Pei, Yunfei Lv, Changguo Li, Dandan Fang