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Promiscuous G-protein activation by the calcium-sensing receptor Nature (IF 64.8) Pub Date : 2024-04-17 Hao Zuo, Jinseo Park, Aurel Frangaj, Jianxiang Ye, Guanqi Lu, Jamie J. Manning, Wesley B. Asher, Zhengyuan Lu, Guo-bin Hu, Liguo Wang, Joshua Mendez, Edward Eng, Zhening Zhang, Xin Lin, Robert Grassucci, Wayne A. Hendrickson, Oliver B. Clarke, Jonathan A. Javitch, Arthur D. Conigrave, Qing R. Fan
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Control of neuronal excitation–inhibition balance by BMP–SMAD1 signalling Nature (IF 64.8) Pub Date : 2024-04-17 Zeynep Okur, Nadia Schlauri, Vassilis Bitsikas, Myrto Panopoulou, Raul Ortiz, Michaela Schwaiger, Kajari Karmakar, Dietmar Schreiner, Peter Scheiffele
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DNA glycosylases provide antiviral defence in prokaryotes Nature (IF 64.8) Pub Date : 2024-04-17 Amer A. Hossain, Ying Z. Pigli, Christian F. Baca, Søren Heissel, Alexis Thomas, Vincent K. Libis, Ján Burian, Joshua S. Chappie, Sean F. Brady, Phoebe A. Rice, Luciano A. Marraffini
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Hybrid speciation driven by multilocus introgression of ecological traits Nature (IF 64.8) Pub Date : 2024-04-17 Neil Rosser, Fernando Seixas, Lucie M. Queste, Bruna Cama, Ronald Mori-Pezo, Dmytro Kryvokhyzha, Michaela Nelson, Rachel Waite-Hudson, Matt Goringe, Mauro Costa, Marianne Elias, Clarisse Mendes Eleres de Figueiredo, André Victor Lucci Freitas, Mathieu Joron, Krzysztof Kozak, Gerardo Lamas, Ananda R. P. Martins, W. Owen McMillan, Jonathan Ready, Nicol Rueda-Muñoz, Camilo Salazar, Patricio Salazar, Stefan
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Methane emission from a cool brown dwarf Nature (IF 64.8) Pub Date : 2024-04-17 Jacqueline K. Faherty, Ben Burningham, Jonathan Gagné, Genaro Suárez, Johanna M. Vos, Sherelyn Alejandro Merchan, Caroline V. Morley, Melanie Rowland, Brianna Lacy, Rocio Kiman, Dan Caselden, J. Davy Kirkpatrick, Aaron Meisner, Adam C. Schneider, Marc Jason Kuchner, Daniella Carolina Bardalez Gagliuffi, Charles Beichman, Peter Eisenhardt, Christopher R. Gelino, Ehsan Gharib-Nezhad, Eileen Gonzales
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Stepwise activation of a metabotropic glutamate receptor Nature (IF 64.8) Pub Date : 2024-04-17 Kaavya Krishna Kumar, Haoqing Wang, Chris Habrian, Naomi R. Latorraca, Jun Xu, Evan S. O’Brien, Chensong Zhang, Elizabeth Montabana, Antoine Koehl, Susan Marqusee, Ehud Y. Isacoff, Brian K. Kobilka
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The economic commitment of climate change Nature (IF 64.8) Pub Date : 2024-04-17 Maximilian Kotz, Anders Levermann, Leonie Wenz
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Neural crest origin of sympathetic neurons at the dawn of vertebrates Nature (IF 64.8) Pub Date : 2024-04-17 Brittany M. Edens, Jan Stundl, Hugo A. Urrutia, Marianne E. Bronner
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Refining the impact of genetic evidence on clinical success Nature (IF 64.8) Pub Date : 2024-04-17 Eric Vallabh Minikel, Jeffery L. Painter, Coco Chengliang Dong, Matthew R. Nelson
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Seismological evidence for a multifault network at the subduction interface Nature (IF 64.8) Pub Date : 2024-04-17 Caroline Chalumeau, Hans Agurto-Detzel, Andreas Rietbrock, Michael Frietsch, Onno Oncken, Monica Segovia, Audrey Galve
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Biogeographic response of marine plankton to Cenozoic environmental changes Nature (IF 64.8) Pub Date : 2024-04-17 Anshuman Swain, Adam Woodhouse, William F. Fagan, Andrew J. Fraass, Christopher M. Lowery
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Control of working memory by phase–amplitude coupling of human hippocampal neurons Nature (IF 64.8) Pub Date : 2024-04-17 Jonathan Daume, Jan Kamiński, Andrea G. P. Schjetnan, Yousef Salimpour, Umais Khan, Michael Kyzar, Chrystal M. Reed, William S. Anderson, Taufik A. Valiante, Adam N. Mamelak, Ueli Rutishauser
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Network-level encoding of local neurotransmitters in cortical astrocytes Nature (IF 64.8) Pub Date : 2024-04-17 Michelle K. Cahill, Max Collard, Vincent Tse, Michael E. Reitman, Roberto Etchenique, Christoph Kirst, Kira E. Poskanzer
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Corner- and edge-mode enhancement of near-field radiative heat transfer Nature (IF 64.8) Pub Date : 2024-04-17 Lei Tang, Lívia M. Corrêa, Mathieu Francoeur, Chris Dames
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Brain endothelial GSDMD activation mediates inflammatory BBB breakdown Nature (IF 64.8) Pub Date : 2024-04-17 Chao Wei, Wei Jiang, Ruiyu Wang, Haoyu Zhong, Huabin He, Xinwei Gao, Shilin Zhong, Fengting Yu, Qingchun Guo, Li Zhang, Lisa D. J. Schiffelers, Bin Zhou, Martin Trepel, Florian I. Schmidt, Minmin Luo, Feng Shao
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Stripped-envelope supernova light curves argue for central engine activity Nature (IF 64.8) Pub Date : 2024-04-17 Ósmar Rodríguez, Ehud Nakar, Dan Maoz
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Environmental drivers of increased ecosystem respiration in a warming tundra Nature (IF 64.8) Pub Date : 2024-04-17 S. L. Maes, J. Dietrich, G. Midolo, S. Schwieger, M. Kummu, V. Vandvik, R. Aerts, I. H. J. Althuizen, C. Biasi, R. G. Björk, H. Böhner, M. Carbognani, G. Chiari, C. T. Christiansen, K. E. Clemmensen, E. J. Cooper, J. H. C. Cornelissen, B. Elberling, P. Faubert, N. Fetcher, T. G. W. Forte, J. Gaudard, K. Gavazov, Z. Guan, J. Guðmundsson, R. Gya, S. Hallin, B. B. Hansen, S. V. Haugum, J.-S. He, C. Hicks
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Machine learning reveals the control mechanics of an insect wing hinge Nature (IF 64.8) Pub Date : 2024-04-17 Johan M. Melis, Igor Siwanowicz, Michael H. Dickinson
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Digital colloid-enhanced Raman spectroscopy by single-molecule counting Nature (IF 64.8) Pub Date : 2024-04-17 Xinyuan Bi, Daniel M. Czajkowsky, Zhifeng Shao, Jian Ye
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Streptomyces umbrella toxin particles block hyphal growth of competing species Nature (IF 64.8) Pub Date : 2024-04-17 Qinqin Zhao, Savannah Bertolli, Young-Jun Park, Yongjun Tan, Kevin J. Cutler, Pooja Srinivas, Kyle L. Asfahl, Citlali Fonesca-García, Larry A. Gallagher, Yaqiao Li, Yaxi Wang, Devin Coleman-Derr, Frank DiMaio, Dapeng Zhang, S. Brook Peterson, David Veesler, Joseph D. Mougous
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Laser spectroscopy of triply charged 229Th isomer for a nuclear clock Nature (IF 64.8) Pub Date : 2024-04-17 Atsushi Yamaguchi, Yudai Shigekawa, Hiromitsu Haba, Hidetoshi Kikunaga, Kenji Shirasaki, Michiharu Wada, Hidetoshi Katori
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Light-wave-controlled Haldane model in monolayer hexagonal boron nitride Nature (IF 64.8) Pub Date : 2024-04-15 Sambit Mitra, Álvaro Jiménez-Galán, Mario Aulich, Marcel Neuhaus, Rui E. F. Silva, Volodymyr Pervak, Matthias F. Kling, Shubhadeep Biswas
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Necroptosis blockade prevents lung injury in severe influenza Nature (IF 64.8) Pub Date : 2024-04-10 Avishekh Gautam, David F. Boyd, Sameer Nikhar, Ting Zhang, Ioannis Siokas, Lee-Ann Van de Velde, Jessica Gaevert, Victoria Meliopoulos, Bikash Thapa, Diego A. Rodriguez, Kathy Q. Cai, Chaoran Yin, Daniel Schnepf, Julius Beer, Carly DeAntoneo, Riley M. Williams, Maria Shubina, Brandi Livingston, Dingqiang Zhang, Mark D. Andrake, Seungheon Lee, Raghavender Boda, Anantha L. Duddupudi, Jeremy Chase Crawford
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FOXO1 is a master regulator of memory programming in CAR T cells Nature (IF 64.8) Pub Date : 2024-04-10 Alexander E. Doan, Katherine P. Mueller, Andy Y. Chen, Geoffrey T. Rouin, Yingshi Chen, Bence Daniel, John Lattin, Martina Markovska, Brett Mozarsky, Jose Arias-Umana, Robert Hapke, In-Young Jung, Alice Wang, Peng Xu, Dorota Klysz, Gabrielle Zuern, Malek Bashti, Patrick J. Quinn, Zhuang Miao, Katalin Sandor, Wenxi Zhang, Gregory M. Chen, Faith Ryu, Meghan Logun, Junior Hall, Kai Tan, Stephan A. Grupp
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Giant energy storage and power density negative capacitance superlattices Nature (IF 64.8) Pub Date : 2024-04-09 Suraj S. Cheema, Nirmaan Shanker, Shang-Lin Hsu, Joseph Schaadt, Nathan M. Ellis, Matthew Cook, Ravi Rastogi, Robert C. N. Pilawa-Podgurski, Jim Ciston, Mohamed Mohamed, Sayeef Salahuddin
Dielectric electrostatic capacitors1, due to their ultrafast charge-discharge capability, are attractive for high power energy storage applications. Along with ultrafast operation, on-chip integration can enable miniaturized energy storage devices for emerging autonomous microelectronics and microsystems2-5. Additionally, state-of-the-art miniaturized electrochemical energy storage systems – microsupercapacitors
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Selenium alloyed tellurium oxide for amorphous p-channel transistors Nature (IF 64.8) Pub Date : 2024-04-10 Ao Liu, Yong-Sung Kim, Min Gyu Kim, Youjin Reo, Taoyu Zou, Taesu Choi, Sai Bai, Huihui Zhu, Yong-Young Noh
Compared to polycrystalline semiconductors, amorphous semiconductors offer inherent cost-effective, simplicity, and uniform manufacturing. Traditional amorphous hydrogenated Si falls short in electrical properties, necessitating the exploration of new materials. The creation of high-mobility amorphous n-type metal oxides, such as a-InGaZnO1, and their integration into thin-film transistors (TFTs) have
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ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D Nature (IF 64.8) Pub Date : 2024-04-10 Gang Du, Liam B. Healy, Liron David, Caitlin Walker, Tarick J. El-Baba, Corinne A. Lutomski, Byoungsook Goh, Bowen Gu, Xiong Pi, Pascal Devant, Pietro Fontana, Ying Dong, Xiyu Ma, Rui Miao, Arumugam Balasubramanian, Robbins Puthenveetil, Anirban Banerjee, Hongbo R. Luo, Jonathan C. Kagan, Sungwhan F. Oh, Carol V. Robinson, Judy Lieberman, Hao Wu
Gasdermin D (GSDMD) is the common effector for cytokine secretion and pyroptosis downstream of inflammasome activation and was previously shown to form large transmembrane pores upon cleavage by inflammatory caspases to generate the GSDMD N-terminal domain (GSDMD-NT)1-10. Here we report that GSDMD Cys191 is S-palmitoylated and palmitoylation is required for pore formation. S-palmitoylation, which does
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Ghost roads and the destruction of Asia-Pacific tropical forests Nature (IF 64.8) Pub Date : 2024-04-10 Jayden E. Engert, Mason J. Campbell, Joshua E. Cinner, Yoko Ishida, Sean Sloan, Jatna Supriatna, Mohammed Alamgir, Jaime Cislowski, William F. Laurance
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Force-controlled release of small molecules with a rotaxane actuator Nature (IF 64.8) Pub Date : 2024-04-10 Lei Chen, Robert Nixon, Guillaume De Bo
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Sex differences orchestrated by androgens at single-cell resolution Nature (IF 64.8) Pub Date : 2024-04-10 Fei Li, Xudong Xing, Qiqi Jin, Xiang-Ming Wang, Pengfei Dai, Ming Han, Huili Shi, Ze Zhang, Xianlong Shao, Yunyi Peng, Yiqin Zhu, Jiayi Xu, Dan Li, Yu Chen, Wei Wu, Qiao Wang, Chen Yu, Luonan Chen, Fan Bai, Dong Gao
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Emergence of fractal geometries in the evolution of a metabolic enzyme Nature (IF 64.8) Pub Date : 2024-04-10 Franziska L. Sendker, Yat Kei Lo, Thomas Heimerl, Stefan Bohn, Louise J. Persson, Christopher-Nils Mais, Wiktoria Sadowska, Nicole Paczia, Eva Nußbaum, María del Carmen Sánchez Olmos, Karl Forchhammer, Daniel Schindler, Tobias J. Erb, Justin L. P. Benesch, Erik G. Marklund, Gert Bange, Jan M. Schuller, Georg K. A. Hochberg
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FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy Nature (IF 64.8) Pub Date : 2024-04-10 Jack D. Chan, Christina M. Scheffler, Isabelle Munoz, Kevin Sek, Joel N. Lee, Yu-Kuan Huang, Kah Min Yap, Nicole Y. L. Saw, Jasmine Li, Amanda X. Y. Chen, Cheok Weng Chan, Emily B. Derrick, Kirsten L. Todd, Junming Tong, Phoebe A. Dunbar, Jiawen Li, Thang X. Hoang, Maria N. de Menezes, Emma V. Petley, Joelle S. Kim, Dat Nguyen, Patrick S. K. Leung, Joan So, Christian Deguit, Joe Zhu, Imran G. House
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Mid-ocean ridge unfaulting revealed by magmatic intrusions Nature (IF 64.8) Pub Date : 2024-04-10 Jean-Arthur Olive, Göran Ekström, W. Roger Buck, Zhonglan Liu, Javier Escartín, Manon Bickert
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Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids Nature (IF 64.8) Pub Date : 2024-04-10 Jean-Philippe Auger, Max Zimmermann, Maria Faas, Ulrich Stifel, David Chambers, Brenda Krishnacoumar, R. Verena Taudte, Charlotte Grund, Gitta Erdmann, Carina Scholtysek, Stefan Uderhardt, Oumaima Ben Brahim, Mónica Pascual Maté, Cornelia Stoll, Martin Böttcher, Katrin Palumbo-Zerr, Matthew S. J. Mangan, Maria Dzamukova, Markus Kieler, Melanie Hofmann, Stephan Blüml, Gernot Schabbauer, Dimitrios Mougiakakos
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Cell-type-resolved mosaicism reveals clonal dynamics of the human forebrain Nature (IF 64.8) Pub Date : 2024-04-10 Changuk Chung, Xiaoxu Yang, Robert F. Hevner, Katie Kennedy, Keng Ioi Vong, Yang Liu, Arzoo Patel, Rahul Nedunuri, Scott T. Barton, Geoffroy Noel, Chelsea Barrows, Valentina Stanley, Swapnil Mittal, Martin W. Breuss, Johannes C. M. Schlachetzki, Stephen F. Kingsmore, Joseph G. Gleeson
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Phononic switching of magnetization by the ultrafast Barnett effect Nature (IF 64.8) Pub Date : 2024-04-10 C. S. Davies, F. G. N. Fennema, A. Tsukamoto, I. Razdolski, A. V. Kimel, A. Kirilyuk
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Distal colonocytes targeted by C. rodentium recruit T-cell help for barrier defence Nature (IF 64.8) Pub Date : 2024-04-10 Carlene L. Zindl, C. Garrett Wilson, Awalpreet S. Chadha, Lennard W. Duck, Baiyi Cai, Stacey N. Harbour, Yoshiko Nagaoka-Kamata, Robin D. Hatton, Min Gao, David A. Figge, Casey T. Weaver
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FSC-certified forest management benefits large mammals compared to non-FSC Nature (IF 64.8) Pub Date : 2024-04-10 Joeri A. Zwerts, E. H. M. Sterck, Pita A. Verweij, Fiona Maisels, Jaap van der Waarde, Emma A. M. Geelen, Georges Belmond Tchoumba, Hermann Frankie Donfouet Zebaze, Marijke van Kuijk
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Ligand efficacy modulates conformational dynamics of the µ-opioid receptor Nature (IF 64.8) Pub Date : 2024-04-10 Jiawei Zhao, Matthias Elgeti, Evan S. O’Brien, Cecília P. Sár, Amal EI Daibani, Jie Heng, Xiaoou Sun, Elizabeth White, Tao Che, Wayne L. Hubbell, Brian K. Kobilka, Chunlai Chen
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Direct observation of a magnetic-field-induced Wigner crystal Nature (IF 64.8) Pub Date : 2024-04-10 Yen-Chen Tsui, Minhao He, Yuwen Hu, Ethan Lake, Taige Wang, Kenji Watanabe, Takashi Taniguchi, Michael P. Zaletel, Ali Yazdani
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A hybrid topological quantum state in an elemental solid Nature (IF 64.8) Pub Date : 2024-04-10 Md Shafayat Hossain, Frank Schindler, Rajibul Islam, Zahir Muhammad, Yu-Xiao Jiang, Zi-Jia Cheng, Qi Zhang, Tao Hou, Hongyu Chen, Maksim Litskevich, Brian Casas, Jia-Xin Yin, Tyler A. Cochran, Mohammad Yahyavi, Xian P. Yang, Luis Balicas, Guoqing Chang, Weisheng Zhao, Titus Neupert, M. Zahid Hasan
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Terahertz electric-field-driven dynamical multiferroicity in SrTiO3 Nature (IF 64.8) Pub Date : 2024-04-10 M. Basini, M. Pancaldi, B. Wehinger, M. Udina, V. Unikandanunni, T. Tadano, M. C. Hoffmann, A. V. Balatsky, S. Bonetti
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Bitter taste receptor activation by cholesterol and an intracellular tastant Nature (IF 64.8) Pub Date : 2024-04-10 Yoojoong Kim, Ryan H. Gumpper, Yongfeng Liu, D. Dewran Kocak, Yan Xiong, Can Cao, Zhijie Deng, Brian E. Krumm, Manish K. Jain, Shicheng Zhang, Jian Jin, Bryan L. Roth
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Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer Nature (IF 64.8) Pub Date : 2024-04-08 Urszula N. Wasko, Jingjing Jiang, Tanner C. Dalton, Alvaro Curiel-Garcia, A. Cole Edwards, Yingyun Wang, Bianca Lee, Margo Orlen, Sha Tian, Clint A. Stalnecker, Kristina Drizyte-Miller, Marie Menard, Julien Dilly, Stephen A. Sastra, Carmine F. Palermo, Marie C. Hasselluhn, Amanda R. Decker-Farrell, Stephanie Chang, Lingyan Jiang, Xing Wei, Yu C. Yang, Ciara Helland, Haley Courtney, Yevgeniy Gindin
Broad-spectrum RAS inhibition holds the potential to benefit roughly a quarter of human cancer patients whose tumors are driven by RAS mutations1,2. RMC-7977 is a highly selective inhibitor of the active GTP-bound forms of KRAS, HRAS, and NRAS, with affinity for both mutant and wild type (WT) variants (RAS(ON) multi-selective)3. As >90% of human pancreatic ductal adenocarcinoma (PDAC) cases are driven
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The PARTNER trial of neoadjuvant olaparib in triple-negative breast cancer Nature (IF 64.8) Pub Date : 2024-04-08 Jean E. Abraham, Karen Pinilla, Alimu Dayimu, Louise Grybowicz, Nikolaos Demiris, Caron Harvey, Lynsey M. Drewett, Rebecca Lucey, Alexander Fulton, Anne N. Roberts, Joanna R. Worley, Anita Chhabra, Wendi Qian, Anne-Laure Vallier, Richard M. Hardy, Steve Chan, Tamas Hickish, Devashish Tripathi, Ramachandran Venkitaraman, Mojca Persic, Shahzeena Aslam, Daniel Glassman, Sanjay Raj, Annabel Borley, Jeremy
PARTNER is a prospective, phase II-III, randomised controlled clinical trial, which recruited patients with Triple Negative Breast Cancer (TNBC)1,2, who were gBRCA wild type (gBRCAwt)3. Patients (n=559) were randomised on a 1:1 basis to neoadjuvant carboplatin with paclitaxel +/- olaparib 150mg twice daily, days 3 to 14, for 4 cycles (gap schedule olaparib, research arm) followed by 3 cycles of anthracycline
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Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy Nature (IF 64.8) Pub Date : 2024-04-08 Matthew Holderfield, Bianca J. Lee, Jingjing Jiang, Aidan Tomlinson, Kyle J. Seamon, Alessia Mira, Enrico Patrucco, Grace Goodhart, Julien Dilly, Yevgeniy Gindin, Nuntana Dinglasan, Yingyun Wang, Lick Pui Lai, Shurui Cai, Lingyan Jiang, Nicole Nasholm, Nataliya Shifrin, Cristina Blaj, Harshit Shah, James W. Evans, Nilufar Montazer, Oliver Lai, Jade Shi, Ethan Ahler, Elsa Quintana, Stephanie Chang,
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Complexity of avian evolution revealed by family-level genomes Nature (IF 64.8) Pub Date : 2024-04-01 Josefin Stiller, Shaohong Feng, Al-Aabid Chowdhury, Iker Rivas-González, David A. Duchêne, Qi Fang, Yuan Deng, Alexey Kozlov, Alexandros Stamatakis, Santiago Claramunt, Jacqueline M. T. Nguyen, Simon Y. W. Ho, Brant C. Faircloth, Julia Haag, Peter Houde, Joel Cracraft, Metin Balaban, Uyen Mai, Guangji Chen, Rongsheng Gao, Chengran Zhou, Yulong Xie, Zijian Huang, Zhen Cao, Zhi Yan, Huw A. Ogilvie, Luay
Despite tremendous efforts in the past decades, relationships among main avian lineages remain heavily debated without a clear resolution. Discrepancies have been attributed to diversity of species sampled, phylogenetic method, and the choice of genomic regions 1–3. Here, we address these issues by analyzing genomes of 363 bird species 4 (218 taxonomic families, 92% of total). Using intergenic regions
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Molecular insights into capsular polysaccharide secretion Nature (IF 64.8) Pub Date : 2024-04-03 Jeremi Kuklewicz, Jochen Zimmer
Capsular polysaccharides (CPSs) fortify the cell boundaries of many commensal and pathogenic bacteria1. Through the ABC-transporter-dependent biosynthesis pathway, CPSs are synthesized intracellularly on a lipid anchor and secreted across the cell envelope by the KpsMT ABC transporter associated with the KpsE and KpsD subunits1,2. Here we use structural and functional studies to uncover crucial steps
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Shell buckling for programmable metafluids Nature (IF 64.8) Pub Date : 2024-04-03 Adel Djellouli, Bert Van Raemdonck, Yang Wang, Yi Yang, Anthony Caillaud, David Weitz, Shmuel Rubinstein, Benjamin Gorissen, Katia Bertoldi
The pursuit of materials with enhanced functionality has led to the emergence of metamaterials—artificially engineered materials whose properties are determined by their structure rather than composition. Traditionally, the building blocks of metamaterials are arranged in fixed positions within a lattice structure1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19. However, recent research has revealed
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Fossils document evolutionary changes of jaw joint to mammalian middle ear Nature (IF 64.8) Pub Date : 2024-04-03 Fangyuan Mao, Chi Zhang, Jicheng Ren, Tao Wang, Guofu Wang, Fakui Zhang, Thomas Rich, Patricia Vickers-Rich, Jin Meng
The dual jaw joint of Morganucodon1,2 consists of the dentary–squamosal joint laterally and the articular–quadrate one medially. The articular–quadrate joint and its associated post-dentary bones constitute the precursor of the mammalian middle ear. Fossils documenting the transition from such a precursor to the mammalian middle ear are poor, resulting in inconsistent interpretations of this hallmark
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Mechanical activation opens a lipid-lined pore in OSCA ion channels Nature (IF 64.8) Pub Date : 2024-04-03 Yaoyao Han, Zijing Zhou, Ruitao Jin, Fei Dai, Yifan Ge, Xisan Ju, Xiaonuo Ma, Sitong He, Ling Yuan, Yingying Wang, Wei Yang, Xiaomin Yue, Zhongwen Chen, Yadong Sun, Ben Corry, Charles D. Cox, Yixiao Zhang
OSCA/TMEM63 channels are the largest known family of mechanosensitive channels1,2,3, playing critical roles in plant4,5,6,7 and mammalian8,9 mechanotransduction. Here we determined 44 cryogenic electron microscopy structures of OSCA/TMEM63 channels in different environments to investigate the molecular basis of OSCA/TMEM63 channel mechanosensitivity. In nanodiscs, we mimicked increased membrane tension
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Phase-change memory via a phase-changeable self-confined nano-filament Nature (IF 64.8) Pub Date : 2024-04-03 See-On Park, Seokman Hong, Su-Jin Sung, Dawon Kim, Seokho Seo, Hakcheon Jeong, Taehoon Park, Won Joon Cho, Jeehwan Kim, Shinhyun Choi
Phase-change memory (PCM) has been considered a promising candidate for solving von Neumann bottlenecks owing to its low latency, non-volatile memory property and high integration density1,2. However, PCMs usually require a large current for the reset process by melting the phase-change material into an amorphous phase, which deteriorates the energy efficiency2,3,4,5. Various studies have been conducted
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Improving prime editing with an endogenous small RNA-binding protein Nature (IF 64.8) Pub Date : 2024-04-03 Jun Yan, Paul Oyler-Castrillo, Purnima Ravisankar, Carl C. Ward, Sébastien Levesque, Yangwode Jing, Danny Simpson, Anqi Zhao, Hui Li, Weihao Yan, Laine Goudy, Ralf Schmidt, Sabrina C. Solley, Luke A. Gilbert, Michelle M. Chan, Daniel E. Bauer, Alexander Marson, Lance R. Parsons, Britt Adamson
Prime editing enables the precise modification of genomes through reverse transcription of template sequences appended to the 3′ ends of CRISPR–Cas guide RNAs1. To identify cellular determinants of prime editing, we developed scalable prime editing reporters and performed genome-scale CRISPR-interference screens. From these screens, a single factor emerged as the strongest mediator of prime editing:
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The variation and evolution of complete human centromeres Nature (IF 64.8) Pub Date : 2024-04-03 Glennis A. Logsdon, Allison N. Rozanski, Fedor Ryabov, Tamara Potapova, Valery A. Shepelev, Claudia R. Catacchio, David Porubsky, Yafei Mao, DongAhn Yoo, Mikko Rautiainen, Sergey Koren, Sergey Nurk, Julian K. Lucas, Kendra Hoekzema, Katherine M. Munson, Jennifer L. Gerton, Adam M. Phillippy, Mario Ventura, Ivan A. Alexandrov, Evan E. Eichler
Human centromeres have been traditionally very difficult to sequence and assemble owing to their repetitive nature and large size1. As a result, patterns of human centromeric variation and models for their evolution and function remain incomplete, despite centromeres being among the most rapidly mutating regions2,3. Here, using long-read sequencing, we completely sequenced and assembled all centromeres
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Bridging structural and cell biology with cryo-electron microscopy Nature (IF 64.8) Pub Date : 2024-04-03 Eva Nogales, Julia Mahamid
Most life scientists would agree that understanding how cellular processes work requires structural knowledge about the macromolecules involved. For example, deciphering the double-helical nature of DNA revealed essential aspects of how genetic information is stored, copied and repaired. Yet, being reductionist in nature, structural biology requires the purification of large amounts of macromolecules
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Interim analyses of a first-in-human phase 1/2 mRNA trial for propionic acidaemia Nature (IF 64.8) Pub Date : 2024-04-03 Dwight Koeberl, Andreas Schulze, Neal Sondheimer, Gerald S. Lipshutz, Tarekegn Geberhiwot, Lerong Li, Rajnish Saini, Junxiang Luo, Vanja Sikirica, Ling Jin, Min Liang, Mary Leuchars, Stephanie Grunewald
Propionic acidaemia is a rare disorder caused by defects in the propionyl-coenzyme A carboxylase α or β (PCCA or PCCB) subunits that leads to an accumulation of toxic metabolites and to recurrent, life-threatening metabolic decompensation events. Here we report interim analyses of a first-in-human, phase 1/2, open-label, dose-optimization study and an extension study evaluating the safety and efficacy
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Heat flows enrich prebiotic building blocks and enhance their reactivity Nature (IF 64.8) Pub Date : 2024-04-03 Thomas Matreux, Paula Aikkila, Bettina Scheu, Dieter Braun, Christof B. Mast
The emergence of biopolymer building blocks is a crucial step during the origins of life1,2,3,4,5,6. However, all known formation pathways rely on rare pure feedstocks and demand successive purification and mixing steps to suppress unwanted side reactions and enable high product yields. Here we show that heat flows through thin, crack-like geo-compartments could have provided a widely available yet
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Structural basis of Integrator-dependent RNA polymerase II termination Nature (IF 64.8) Pub Date : 2024-04-03 Isaac Fianu, Moritz Ochmann, James L. Walshe, Olexandr Dybkov, Joseph Neos Cruz, Henning Urlaub, Patrick Cramer
The Integrator complex can terminate RNA polymerase II (Pol II) in the promoter-proximal region of genes. Previous work has shed light on how Integrator binds to the paused elongation complex consisting of Pol II, the DRB sensitivity-inducing factor (DSIF) and the negative elongation factor (NELF) and how it cleaves the nascent RNA transcript1, but has not explained how Integrator removes Pol II from
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A brain-specific angiogenic mechanism enabled by tip cell specialization Nature (IF 64.8) Pub Date : 2024-04-03 Giel Schevenels, Pauline Cabochette, Michelle America, Arnaud Vandenborne, Line De Grande, Stefan Guenther, Liqun He, Marc Dieu, Basile Christou, Marjorie Vermeersch, Raoul F. V. Germano, David Perez-Morga, Patricia Renard, Maud Martin, Michael Vanlandewijck, Christer Betsholtz, Benoit Vanhollebeke
Vertebrate organs require locally adapted blood vessels1,2. The gain of such organotypic vessel specializations is often deemed to be molecularly unrelated to the process of organ vascularization. Here, opposing this model, we reveal a molecular mechanism for brain-specific angiogenesis that operates under the control of Wnt7a/b ligands—well-known blood–brain barrier maturation signals3,4,5. The control
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An optical tweezer array of ultracold polyatomic molecules Nature (IF 64.8) Pub Date : 2024-04-03 Nathaniel B. Vilas, Paige Robichaud, Christian Hallas, Grace K. Li, Loïc Anderegg, John M. Doyle
Polyatomic molecules have rich structural features that make them uniquely suited to applications in quantum information science1,2,3, quantum simulation4,5,6, ultracold chemistry7 and searches for physics beyond the standard model8,9,10. However, a key challenge is fully controlling both the internal quantum state and the motional degrees of freedom of the molecules. Here we demonstrate the creation