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Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology Sci. Transl. Med. (IF 17.1) Pub Date : 2024-04-17 Hoang Van Phan, Alexandra Tsitsiklis, Cole P. Maguire, Elias K. Haddad, Patrice M. Becker, Seunghee Kim-Schulze, Brian Lee, Jing Chen, Annmarie Hoch, Harry Pickering, Patrick van Zalm, Matthew C. Altman, Alison D. Augustine, Carolyn S. Calfee, Steve Bosinger, Charles B. Cairns, Walter Eckalbar, Leying Guan, Naresh Doni Jayavelu, Steven H. Kleinstein, Florian Krammer, Holden T. Maecker, Al Ozonoff,
Age is a major risk factor for severe coronavirus disease 2019 (COVID-19), yet the mechanisms behind this relationship have remained incompletely understood. To address this, we evaluated the impact of aging on host immune response in the blood and the upper airway, as well as the nasal microbiome in a prospective, multicenter cohort of 1031 vaccine-naïve patients hospitalized for COVID-19 between
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Climate change and health: understanding mechanisms will inform mitigation and prevention strategies Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Diddier Prada, Andrea A. Baccarelli, Allison Kupsco, Robbie M. Parks
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Post-election responsibilities for public health in the Democratic Republic of the Congo Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Faraan O. Rahim, William C. Lieber, Julian T. Hertz, Bruce Shinga Wembulua, Patrick A. Ndeba, Richard M. Lukelwa
Since gaining independence in 1960, the Democratic Republic of the Congo (DRC) has faced a complicated series of challenges marked by armed conflict, political instability and economic hardships. Tensions in the DRC are on an escalating trajectory as the Congolese army and its allied militias battle with the March 23 Movement group in North and South Kivu. Attempts to restore peace through the Nairobi
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Opportunities and challenges following approval of resmetirom for MASH liver disease Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Jeffrey V. Lazarus, Dana Ivancovsky Wajcman, Henry E. Mark, Zobair M. Younossi, Christopher J. Kopka, Nevin Cohen, Meena B. Bansal, Michael Betel, Paul N. Brennan
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An autoantibody signature predictive for multiple sclerosis Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Colin R. Zamecnik, Gavin M. Sowa, Ahmed Abdelhak, Ravi Dandekar, Rebecca D. Bair, Kristen J. Wade, Christopher M. Bartley, Kerry Kizer, Danillo G. Augusto, Asritha Tubati, Refujia Gomez, Camille Fouassier, Chloe Gerungan, Colette M. Caspar, Jessica Alexander, Anne E. Wapniarski, Rita P. Loudermilk, Erica L. Eggers, Kelsey C. Zorn, Kirtana Ananth, Nora Jabassini, Sabrina A. Mann, Nicholas R. Ragan,
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Causal machine learning for predicting treatment outcomes Nat. Med. (IF 82.9) Pub Date : 2024-04-19 Stefan Feuerriegel, Dennis Frauen, Valentyn Melnychuk, Jonas Schweisthal, Konstantin Hess, Alicia Curth, Stefan Bauer, Niki Kilbertus, Isaac S. Kohane, Mihaela van der Schaar
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Doctors should not be simply the ghost in the machine BMJ (IF 105.7) Pub Date : 2024-04-19 Matt Morgan, Kieran Walsh
> “Sometimes the questions are complicated and the answers are simple.” > > Dr Seuss Saying the word “finals” to any doctor fills them with a range of emotions, even though the old “big bang” exam at the end of training has largely disappeared. Now it seems the General Medical Council (GMC) wants to rationalise medical examinations even further. In its recent statement on the future of medical education
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Why hospital capacity is more complex than bed capacity BMJ (IF 105.7) Pub Date : 2024-04-18 Kamran Abbasi
It’s easy and somewhat commonplace to liken healthcare to a widget factory, to boil it down to inputs and outputs; to capacity, productivity, and efficiency. I was reminded of this at last week’s international quality and safety forum, jointly hosted by BMJ and the Institute for Healthcare Improvement. The event was held at the ExCel, London’s homage to the austere corridor world of Blake’s 7 —and
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Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human Sci. Transl. Med. (IF 17.1) Pub Date : 2024-04-17 Jason D. Roh, Claire Castro, Andy Z. Yu, Sarosh Rana, Sajid Shahul, Kathryn J. Gray, Michael C. Honigberg, Melanie Ricke-Hoch, Yoshiko Iwamoto, Ashish S. Yeri, Robert Kitchen, Justin Baldovino Guerra, Ryan Hobson, Vinita Chaudhari, Bliss Chang, Amy Sarma, Carolin Lerchenmüller, Zeina R. Al Sayed, Carmen Diaz Verdugo, Peng Xia, Niv Skarbianskis, Amit Zeisel, Johann Bauersachs, James L. Kirkland, S.
Peripartum cardiomyopathy (PPCM) is an idiopathic form of pregnancy-induced heart failure associated with preeclampsia. Circulating factors in late pregnancy are thought to contribute to both diseases, suggesting a common underlying pathophysiological process. However, what drives this process remains unclear. Using serum proteomics, we identified the senescence-associated secretory phenotype (SASP)
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Development and validation of a new algorithm for improved cardiovascular risk prediction Nat. Med. (IF 82.9) Pub Date : 2024-04-18 Julia Hippisley-Cox, Carol A. C. Coupland, Mona Bafadhel, Richard E. K. Russell, Aziz Sheikh, Peter Brindle, Keith M. Channon
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Targeting KRAS in cancer Nat. Med. (IF 82.9) Pub Date : 2024-04-18 Anupriya Singhal, Bob T. Li, Eileen M. O’Reilly
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An Omicron-specific, self-amplifying mRNA booster vaccine for COVID-19: a phase 2/3 randomized trial Nat. Med. (IF 82.9) Pub Date : 2024-04-18 Amit Saraf, Rohan Gurjar, Swarnendu Kaviraj, Aishwarya Kulkarni, Durgesh Kumar, Ruta Kulkarni, Rashmi Virkar, Jayashri Krishnan, Anjali Yadav, Ekta Baranwal, Ajay Singh, Arjun Raghuwanshi, Praveen Agarwal, Laxman Savergave, Sanjay Singh
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Fair Allocation of GLP-1 and Dual GLP-1–GIP Receptor Agonists N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-17 Ezekiel J. Emanuel, Johan L. Dellgren, Matthew S. McCoy, and Govind Persad From the Department of Medical Ethics and Health Policy, Perelman School of Medicine, University of Pennsylvania, Philadelphia (E.J.E., J.L.D., M.S.M.), the Bergen Center for Ethics and Priority Setting, University of Bergen, Bergen, Norway (E.J.E., J.L.D., M.S.M., G.P.), and the Sturm College of Law, University of Denver, Denver
A shortage of GLP-1 receptor agonists and other drugs raises questions about how limited supplies should be allocated. A proposed framework could guide governments, professional societies, and phys...
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Injured, Not Sidelined N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-18
This season finale examines the moral injury that the current U.S. health care system inflicts on physicians and trainees — and how they may be able to offer care that aligns with their values.
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Case 12-2024: A 58-Year-Old Woman with Confusion, Aphasia, and Abnormal Head Imaging N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-18 Richard C. Cabot, Eric S. Rosenberg, David M. Dudzinski, Meridale V. Baggett, Kathy M. Tran, Dennis C. Sgroi, Jo-Anne O. Shepard, Emily K. McDonald, and Tara Corpuz, Jenny J. Linnoila, Otto Rapalino, Melissa A. Walker, and Maria Martinez-Lage From the Department of Neurology, University of Pittsburgh Medical Center, University of Pittsburgh School of Medicine, Pittsburgh (J.J.L.), and the Departments
A 58-year-old woman was transferred to the hospital after 16 months of waxing and waning confusion and aphasia and evolving changes on MRI of the head. A diagnosis was made.
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Aortic Coarctation N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-18 Bailang Chen, and Minxin Wei The University of Hong Kong–Shenzhen Hospital, Shenzhen, China
A 35-year-old man received an incidental diagnosis of hypertension during a routine medical assessment. Computed tomographic angiography revealed aortic coarctation.
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Adjuvant Immunotherapy for Kidney Cancer — A New Strategy with New Challenges N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-18 Martin H. Voss, and Robert J. Motzer From Memorial Sloan Kettering Cancer Center, New York.
Surgery with curative intent constitutes the standard of care for patients with advanced renal-cell carcinoma, yet more than 50% of patients with high-risk features will have disease recurrence. Tw...
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Outbreak of Listeriosis Associated with Consumption of Vegan Cheese N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-18 Alexandre Leclercq Institut Pasteur, Paris, France, Mathieu Tourdjman Santé Publique France, Saint-Maurice, France, Wesley Mattheus Sciensano, Brussels, Belgium, Ingrid Friesema Rijksinstituut voor Volksgezondheid en Milieu, Utrecht, the Netherlands, Nina M. van Sorge Amsterdam UMC, Amsterdam, the Netherlands, Sven Halbedel, and Hendrik Wilking Robert Koch Institute, Berlin, Germany, Marc Lecuit Institut
Plant-based cheeses are marketed as safe alternatives to raw-milk cheese for populations at high risk for foodborne infection. Listeriosis cases in Europe, including in pregnancy, were linked to co...
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On Calling N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-18
To the Editor: Rosenbaum’s cri de coeur in her Medicine and Society article (Feb. 1 issue)1 omits the role of physicians in the genesis of our present system. Before the post–World War II era, Amer...
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Four-Drug Therapy for Multiple Myeloma N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-18
To the Editor: In the PERSEUS trial reported by Sonneveld et al. (Jan. 25 issue),1 transplantation-eligible patients with newly diagnosed multiple myeloma were assigned to receive either subcutaneo...
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Stroke Prevention in Subclinical Atrial Fibrillation N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-18
To the Editor: In the ARTESIA trial involving patients with subclinical atrial fibrillation, Healey and colleagues (Jan. 11 issue)1 compared apixaban with aspirin with respect to stroke or systemic...
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Peripartum Cardiomyopathy N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-18
To the Editor: The review of peripartum cardiomyopathy by Arany (Jan. 11 issue)1 suggests that hormonal changes are the main culprit underlying the condition. In light of the widely held opinion th...
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Retinoblastoma Origins and Destinations N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-18 Dan L. Longo, David Cobrinik From the Vision Center, Department of Surgery, and Saban Research Institute, Children’s Hospital Los Angeles, and the Departments of Ophthalmology and Biochemistry and Molecular Medicine, Roski Eye Institute, and Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California — both in Los Angeles.
The study of retinoblastoma has led to fundamental insights into carcinogenesis, cell-cycle regulation, the genetic basis of cancer, and tumor-suppressor genes, as well as to advances in therapy.
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Overall Survival with Adjuvant Pembrolizumab in Renal-Cell Carcinoma N. Engl. J. Med. (IF 158.5) Pub Date : 2024-04-18 Toni K. Choueiri, Piotr Tomczak, Se Hoon Park, Balaji Venugopal, Tom Ferguson, Stefan N. Symeonides, Jaroslav Hajek, Yen-Hwa Chang, Jae-Lyun Lee, Naveed Sarwar, Naomi B. Haas, Howard Gurney, Piotr Sawrycki, Mauricio Mahave, Marine Gross-Goupil, Tian Zhang, John M. Burke, Gurjyot Doshi, Bohuslav Melichar, Evgeniy Kopyltsov, Ajjai Alva, Stephane Oudard, Delphine Topart, Hans Hammers, Hiroshi Kitamura
Adjuvant pembrolizumab therapy after surgery for renal-cell carcinoma was approved on the basis of a significant improvement in disease-free survival in the KEYNOTE-564 trial. Whether the results r...
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Multiple adverse outcomes associated with antipsychotic use in people with dementia: population based matched cohort study BMJ (IF 105.7) Pub Date : 2024-04-17 Pearl L H Mok, Matthew J Carr, Bruce Guthrie, Daniel R Morales, Aziz Sheikh, Rachel A Elliott, Elizabeth M Camacho, Tjeerd van Staa, Anthony J Avery, Darren M Ashcroft
Objective To investigate risks of multiple adverse outcomes associated with use of antipsychotics in people with dementia. Design Population based matched cohort study. Setting Linked primary care, hospital and mortality data from Clinical Practice Research Datalink (CPRD), England. Population Adults (≥50 years) with a diagnosis of dementia between 1 January 1998 and 31 May 2018 (n=173 910, 63.0% women)
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Mental health support for doctors—a vital yet fragile lifeline BMJ (IF 105.7) Pub Date : 2024-04-18 Lucy Hanington
Even as a doctor myself, it's easy to take other doctors for granted. As a population, we have come to assume that we will be cared for in our hour of need, spoilt by the ready provision of the NHS. But the NHS succeeds because of those who work for it. As an institution it relies on professionals who go above and beyond again and again, who have sacrificed years of their lives to studying and striving
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Partha Kar: We need to level up all staff, not level down doctors BMJ (IF 105.7) Pub Date : 2024-04-18 Partha Kar
After years of underfunding, being undervalued, and issues around pay and working conditions, something finally seems to have changed for doctors. Whisper it softly, but there seem to be signs that they’re acting more collectively against changes they disagree with in the healthcare system. I suspect that much of the credit must go to the younger generation, for speaking up and pushing back against
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The use of continuous glucose monitoring devices in non-diabetic adults … and other research BMJ (IF 105.7) Pub Date : 2024-04-18 Tom Nolan
Tom Nolan reviews this week’s research The market for continuous glucose monitoring (CGM) devices now goes well beyond just being used for people with diabetes. They’re advertised as a means of getting a “deeper understanding” of your body and getting to the “root cause” of health problems. Dubious claims aside, a study in Nature Medicine highlights the need for clarity on how to interpret fasting
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Treating psychosis . . . and other stories BMJ (IF 105.7) Pub Date : 2024-04-18 British Medical Journal Publishing Group
The calming properties of chlorpromazine, the first major tranquilliser, were noticed almost by accident in the early 1950s by a French surgeon who was experimenting with it as a preparation for anaesthesia. Despite the lack of clinical trials, the drug was rapidly taken up by psychiatrists for the treatment of schizophrenia and mania, which allowed them to abandon insulin induced comas, shock treatments
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A large oronasal defect BMJ (IF 105.7) Pub Date : 2024-04-18 Manuel Schoch, Christoph Schlegel
A man in his late 50s with a history of regular cocaine use reported dysphagia, weight loss, and sticking chewing gum to his hard palate to stop food entering his nose (fig 1). On examination he had a nasal voice …
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Urgent action and legislation are needed to tackle overseas bariatric and cosmetic tourism BMJ (IF 105.7) Pub Date : 2024-04-17 Daniel J Chivers, William Watkinson, Humairaa Asmal, Joseph Stallard
We were pleased to read the article highlighting the ongoing problem of complications from overseas surgery.1 Our department has seen several patients with emergency complications associated with cosmetic tourism in the past year. The most common reasons for seeking surgery abroad are inability to access NHS care and inability to afford private UK alternatives.2 Most patients presenting with complications
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AI is unlikely to revolutionise GP access BMJ (IF 105.7) Pub Date : 2024-04-18 Dylan Summers
Mathew has great hopes for the use of artificial intelligence (AI) in GP triage.1 The question I would like her to consider is: is she willing to rely on it unsupervised? At the practice I work at, …
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Can a worker cooperative model of social care improve the patient experience and reduce pressure on GPs? BMJ (IF 105.7) Pub Date : 2024-04-18 Sally Howard
Chronically underfunded and with hundreds of thousands of roles vacant, social care is in crisis, piling pressure on frontline services and GPs. One solution comes from an old idea: a care workers’ cooperative. Sally Howard reports For years, Kate Smyth found that getting help through private social care providers for basic tasks, such as dressing and washing, was “a nightmare.” The West Yorkshire
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Health under the spotlight in India’s 2024 election BMJ (IF 105.7) Pub Date : 2024-04-18 Kamala Thiagarajan
India’s marathon 2024 election process sees several health matters coming to the fore, including universal healthcare, the health workforce, and infrastructure. Kamala Thiagarajan reports When Parth Sharma, a community medicine doctor at the Maulana Azad Medical College in New Delhi, travelled to Tandi, a Himalayan village in the northern Indian state of Himachal Pradesh, he noticed the strong internet
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A girl with circular erythema on the forearm BMJ (IF 105.7) Pub Date : 2024-04-18 Ying Gu, Rui He, Bin Zhang
An 11 year old girl was referred to the dermatology clinic with circular urticarial lesions mainly on the forearm of the non-dominant arm (fig1, left panel). The lesions appeared every morning and lasted for 2-3 hours accompanied by pain. During hospital admission two weeks previously, the patient had been told the lesions were due to vasculitis. She received a course of systemic glucocorticoid treatment
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Use of antipsychotics in adults with dementia BMJ (IF 105.7) Pub Date : 2024-04-17 Raya Elfadel Kheirbek, Cristina LaFon
New study identifies a wider range of associated harm The linked study by Mok and colleagues (doi:10.1136/bmj-2023-076268) provides new insights into the risks associated with use of antipsychotics in dementia care.1 This population based matched cohort design compared the incidence of serious adverse outcomes, including stroke, venous thromboembolism, myocardial infarction, heart failure, fracture
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Duration of cardiopulmonary resuscitation and outcomes for adults with in-hospital cardiac arrest: retrospective cohort study BMJ (IF 105.7) Pub Date : 2024-04-18 British Medical Journal Publishing Group
In the visual abstract of this research paper by Okubo and colleagues (BMJ 2024;384:e076019, doi:10.1136/bmj-2024-076019 …
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TRIPOD+AI statement: updated guidance for reporting clinical prediction models that use regression or machine learning methods BMJ (IF 105.7) Pub Date : 2024-04-18 British Medical Journal Publishing Group
In this paper by Collins and colleagues ( BMJ 2024;385:e078378, doi:10.1136/bmj-2023-078378, published 16 April 2024), …
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What Is Hepatitis D Infection? JAMA (IF 120.7) Pub Date : 2024-04-18 Rebecca Voelker
This JAMA Patient Page describes hepatitis D infection and its risk factors, outcomes of acute and chronic infection, diagnosis, treatment, and prevention.
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“The Patient” JAMA (IF 120.7) Pub Date : 2024-04-18 Katie A. Thure
When a resident announced that “the patient has no chance of surviving,” a medical student, in this narrative medicine essay, has pondered for years how her mother could have been so reduced and advocates using patients’ names when summarizing their conditions.
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The fasciola cinereum of the hippocampal tail as an interventional target in epilepsy Nat. Med. (IF 82.9) Pub Date : 2024-04-17 Ryan M. Jamiolkowski, Quynh-Anh Nguyen, Jordan S. Farrell, Ryan J. McGinn, David A. Hartmann, Jeff J. Nirschl, Mateo I. Sanchez, Vivek P. Buch, Ivan Soltesz
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Nicotine e-cigarettes: considerations for healthcare providers Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Benjamin A. Toll, Tracy T. Smith, Brian A. King
Tobacco use continues to be the leading cause of preventable disease and death in the United States. There are no safe tobacco products; however, the health risks for tobacco products exist on a continuum, with combustible products such as cigarettes being the most harmful. Decades of research have documented that cigarette smoking harms nearly every organ of the body; cigarette smoke contains nearly
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A framework for implementing patient-reported outcomes in clinical care: the PROTEUS-practice guide Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Norah L. Crossnohere, Nicola Anderson, Judith Baumhauer, Melanie Calvert, Rebecca Esparza, Sandi Gulbransen, Lotte Haverman, Yuchen Li, Carolyn Petersen, Ameeta Retzer, Christopher Sidey-Gibbons, Angela M. Stover, Elissa Thorner, Garrett Ursin, Galina Velikova, Elliott Sparkman Walker, Michael Brundage, Claire Snyder
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Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Marie-France Hivert, Frédérique White, Catherine Allard, Kaitlyn James, Sana Majid, François Aguet, Kristin G. Ardlie, Jose C. Florez, Andrea G. Edlow, Luigi Bouchard, Pierre-Étienne Jacques, S. Ananth Karumanchi, Camille E. Powe
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Prediction of tumor origin in cancers of unknown primary origin with cytology-based deep learning Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Fei Tian, Dong Liu, Na Wei, Qianqian Fu, Lin Sun, Wei Liu, Xiaolong Sui, Kathryn Tian, Genevieve Nemeth, Jingyu Feng, Jingjing Xu, Lin Xiao, Junya Han, Jingjie Fu, Yinhua Shi, Yichen Yang, Jia Liu, Chunhong Hu, Bin Feng, Yan Sun, Yunjun Wang, Guohua Yu, Dalu Kong, Meiyun Wang, Wencai Li, Kexin Chen, Xiangchun Li
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Transparent medical image AI via an image–text foundation model grounded in medical literature Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Chanwoo Kim, Soham U. Gadgil, Alex J. DeGrave, Jesutofunmi A. Omiye, Zhuo Ran Cai, Roxana Daneshjou, Su-In Lee
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Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson’s disease Nat. Med. (IF 82.9) Pub Date : 2024-04-15 Gennaro Pagano, Kirsten I. Taylor, Judith Anzures Cabrera, Tanya Simuni, Kenneth Marek, Ronald B. Postuma, Nicola Pavese, Fabrizio Stocchi, Kathrin Brockmann, Hanno Svoboda, Dylan Trundell, Annabelle Monnet, Rachelle Doody, Paulo Fontoura, Geoffrey A. Kerchner, Patrik Brundin, Tania Nikolcheva, Azad Bonni
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How to communicate about climate change with patients BMJ (IF 105.7) Pub Date : 2024-04-17 John Kotcher, Lisa Patel, Stefan Wheat, Rebecca Philipsborn, Edward Maibach
### What you need to know Climate change is arguably the most significant global health threat of the 21st century.1 Despite the increasingly visible impacts of climate change on our lives and health, conversations about climate change seem to have been shut out of the consultation. Where time and resources are under pressure, there may be little room for wider health promotion and conversations about
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John Launer: Learning from appraisals BMJ (IF 105.7) Pub Date : 2024-04-17 John Launer
I’ve been a GP appraiser for around 20 years, more or less since appraisals were introduced. I’ve appraised colleagues across the professional spectrum, from those in serious trouble with the General Medical Council to deans of medical schools who happened to be GPs. I’ve also had many appraisals myself. Some of these have been inspiring and influential on my career, while others have been humdrum
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Health literacy matters BMJ (IF 105.7) Pub Date : 2024-04-17 Tessa Richards
New initiatives to boost health literacy in populations and organisations need broad input from patients and the public, says Tessa Richards “Sunshine, rest, exercise, diet, friends, and self-confidence” are the “six best doctors in the world,” is a popular quote. As a patient with multiple long term conditions, I’d add “peer support” to that list. I know from firsthand experience how the solidarity
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Helen Salisbury: With the NHS in crisis, why is Labour looking to private hospitals as the solution? BMJ (IF 105.7) Pub Date : 2024-04-17 Helen Salisbury
This week the shadow health secretary, Wes Streeting, promised to bring in the private sector to help reduce NHS waiting lists. He also stated that no extra resources would be available for the health service under a Labour government.1 One of the problems with this plan is that it assumes separate sets of doctors and nurses in the NHS and the private sector, with the latter group currently underemployed
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Breaking free from the stigma of diabetes BMJ (IF 105.7) Pub Date : 2024-04-17 Jazz Sethi
Stigma has tangible consequences for clinical outcomes, quality of life, and wellbeing of people with living with diabetes, says Jazz Sethi Have you ever felt the cold prickle of eyes staring at you as they silently pass judgment? Stigma is a term that carries the weight of unsaid words. And while the Oxford Dictionary might define it neatly, its repercussions are messier and more tangible in daily
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Public awareness campaign on risks of accessing weight loss surgery overseas is crucial BMJ (IF 105.7) Pub Date : 2024-04-16 Sala Abdalla
Patients need clearer warnings about the risks of having surgery abroad.1 Health tourism in weight loss and aesthetic surgery is happening with accelerating frequency. In the past few months I have had to manage several patients who had bariatric and aesthetic surgery abroad and returned with complications. I hear stories from patients about advertising that lures them to clinics …
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Concerns over physician associates are missing the wood for the trees BMJ (IF 105.7) Pub Date : 2024-04-17 Morton M Warner
Mafi, Oliver, and Salisbury identify myriad problems with the expanding workforce of physician associates (PAs).123 “Form follows function” has long been the mantra of architects. The NHS should adopt it when planning the future role of PAs. There has never been a clear policy on the clinical needs PAs should respond to or where they should be located …
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Closing the gender health gap: a £39bn boost to the economy, as well as lives BMJ (IF 105.7) Pub Date : 2024-04-17 Sarah Graham
The UK has the 12th largest gender health gap in the world. Closing it will require investment, but would also reap rewards for women and the country, reports Sarah Graham Closing the gender health gap by 2040 could add almost £39bn to the UK economy and give each British woman around 9.5 more days of good health a year. That’s according to data shared with The BMJ by the McKinsey Health Institute
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Child health: UK must regain “lost ground,” Kingdon urges next government BMJ (IF 105.7) Pub Date : 2024-04-17 Gareth Iacobucci
The outgoing RCPCH president is “ashamed” of the state of child health in the UK, she tells Gareth Iacobucci . But there are quick wins and more ambitious ideas that could turn things around with the right political will “I am a very optimistic, glass half full person. But I think we’re in a really bad position in terms of child health in this country,” says Camilla Kingdon. After a proactive three
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A Patient With Type 1 Diabetes and Acute Rhinosinusitis JAMA (IF 120.7) Pub Date : 2024-04-17 Francisco J. Machiavello Roman, Marwan M. Azar, Paul A. Trubin
A 41-year-old with type 1 diabetes had generalized weakness, muffled voice, and slurred speech. Neck computed tomography showed soft-tissue gas in the nasopharynx and prevertebral fascia; examination of sinus mucosal samples identified numerous broad, nonseptate right-angled hyphae and fruiting bodies. What is the diagnosis and what would you do next?
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Accelerating Climate Action Through Academic Health Systems JAMA (IF 120.7) Pub Date : 2024-04-17 A. Eugene Washington, William T. Mallon, Johnese Spisso
This Viewpoint makes the case for academic health systems to lead the way on climate change action in the US, including planning to reduce greenhouse gas emissions, educating current and future clinicians, and communicating with their patients and communities.
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Nociceptor spontaneous activity is responsible for fragmenting non–rapid eye movement sleep in mouse models of neuropathic pain Sci. Transl. Med. (IF 17.1) Pub Date : 2024-04-17 Chloe Alexandre, Giulia Miracca, Victor Duarte Holanda, Ashley Sharma, Kamila Kourbanova, Ashley Ferreira, Maíra A. Bicca, Xiangsunze Zeng, Victoria A. Nassar, Seungkyu Lee, Satvinder Kaur, Sridevi V. Sarma, Pierre Sacré, Thomas E. Scammell, Clifford J. Woolf, Alban Latremoliere
Spontaneous pain, a major complaint of patients with neuropathic pain, has eluded study because there is no reliable marker in either preclinical models or clinical studies. Here, we performed a comprehensive electroencephalogram/electromyogram analysis of sleep in several mouse models of chronic pain: neuropathic (spared nerve injury and chronic constriction injury), inflammatory (Freund’s complete
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Increased β 2 -adrenergic signaling promotes fracture healing through callus neovascularization in mice Sci. Transl. Med. (IF 17.1) Pub Date : 2024-04-17 Denise Jahn, Paul Richard Knapstein, Ellen Otto, Paul Köhli, Jan Sevecke, Frank Graef, Christine Graffmann, Melanie Fuchs, Shan Jiang, Mayla Rickert, Cordula Erdmann, Jessika Appelt, Lawik Revend, Quin Küttner, Jason Witte, Adibeh Rahmani, Georg Duda, Weixin Xie, Antonia Donat, Thorsten Schinke, Andranik Ivanov, Mireille Ngokingha Tchouto, Dieter Beule, Karl-Heinz Frosch, Anke Baranowsky, Serafeim
Traumatic brain injury (TBI) leads to skeletal changes, including bone loss in the unfractured skeleton, and paradoxically accelerates healing of bone fractures; however, the mechanisms remain unclear. TBI is associated with a hyperadrenergic state characterized by increased norepinephrine release. Here, we identified the β 2 -adrenergic receptor (ADRB2) as a mediator of skeletal changes in response