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Going the extra mile to increase vaccine uptake Nat. Med. (IF 82.9) Pub Date : 2024-03-28
Deployment of mobile vaccination teams to remote communities in Sierra Leone substantially increased COVID-19 vaccine uptake, and could potentially be bundled with other health interventions.
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Microplastics at heart of the problem Nat. Med. (IF 82.9) Pub Date : 2024-03-27
Patients with carotid artery plaque that contain microplastics and nanoplastics were found to be at higher risk of cardiovascular events and mortality than those in whom the particles were not detected.
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A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results Nat. Med. (IF 82.9) Pub Date : 2024-03-27 Amy R. Rappaport, Chrisann Kyi, Monica Lane, Meghan G. Hart, Melissa L. Johnson, Brian S. Henick, Chih-Yi Liao, Amit Mahipal, Ardaman Shergill, Alexander I. Spira, Jonathan W. Goldman, Ciaran D. Scallan, Desiree Schenk, Christine D. Palmer, Matthew J. Davis, Sonia Kounlavouth, Lindsey Kemp, Aaron Yang, Yaojun John Li, Molly Likes, Annie Shen, Gregory R. Boucher, Milana Egorova, Robert L. Veres, J.
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Combination treatment for immune-mediated HIV remission Nat. Med. (IF 82.9) Pub Date : 2024-03-26
In rhesus macaques, treatment with an IL-15 superagonist and broad neutralizing antibodies led to durable suppression of viremia after discontinuation of antiretroviral therapy.
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Derivation and external validation of a simple risk score for predicting severe acute kidney injury after intravenous cisplatin: cohort study BMJ (IF 105.7) Pub Date : 2024-03-27 Shruti Gupta, Ilya G Glezerman, Jamie S Hirsch, Kevin L Chen, Nishant Devaraj, Sophia L Wells, Robert H Seitter, Sarah A Kaunfer, Arunima M Jose, Shreya P Rao, Jessica L Ortega, Olivia Green-Lingren, Robert Hayden, Pavan K Bendapudi, Donald F Chute, Meghan E Sise, Kenar D Jhaveri, Valda D Page, Matthew H Abramson, Shveta S Motwani, Wenxin Xu, Kartik Sehgal, Kerry L Reynolds, Anip Bansal, Ala Abudayyeh
Objective To develop and externally validate a prediction model for severe cisplatin associated acute kidney injury (CP-AKI). Design Multicenter cohort study. Setting Six geographically diverse major academic cancer centers across the US. Participants Adults (≥18 years) receiving their first dose of intravenous cisplatin, 2006-22. Main outcome measures The primary outcome was CP-AKI, defined as a twofold
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Delirium and incident dementia in hospital patients in New South Wales, Australia: retrospective cohort study BMJ (IF 105.7) Pub Date : 2024-03-27 Emily H Gordon, David D Ward, Hao Xiong, Shlomo Berkovsky, Ruth E Hubbard
Objectives To determine the strength and nature of the association between delirium and incident dementia in a population of older adult patients without dementia at baseline. Design Retrospective cohort study using large scale hospital administrative data. Setting Public and private hospitals in New South Wales, Australia between July 2001 and March 2020. Participants Data were extracted for 650 590
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Use of progestogens and the risk of intracranial meningioma: national case-control study BMJ (IF 105.7) Pub Date : 2024-03-27 Noémie Roland, Anke Neumann, Léa Haszard, Lise Duranteau, Sébastien Froelich, Mahmoud Zureik, Alain Weill
Objective To assess the risk of intracranial meningioma associated with the use of selected progestogens. Design National case-control study. Setting French National Health Data System (ie, Système National des Données de Santé ). Participants Of 108 366 women overall, 18 061 women living in France who had intracranial surgery for meningioma between 1 January 2009 and 31 December 2018 (restricted inclusion
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Public health is in crisis, but it can be fixed BMJ (IF 105.7) Pub Date : 2024-03-27 David J Hunter, Peter Littlejohns, Albert Weale
Public health has been undermined by the UK government and we must respond by strengthening policy and leadership, say David J Hunter and colleagues Since 2010 a combination of austerity, Brexit, and the impact of covid-19 has considerably worsened the public’s health in England.123 Obesity levels have risen, fuelled by the consumption of unregulated ultra-processed foods, a chronic problem which successive
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We need more data to help guide the care of patients with cancer who develop kidney related problems BMJ (IF 105.7) Pub Date : 2024-03-27 Shruti Gupta, David E Leaf
Healthcare staff caring for patients with cancer must have access to high quality and generalizable data regarding the toxicities and repercussions of cancer treatments Onconephrology, the intersection between oncology and nephrology, is a rapidly evolving field that has gained considerable interest over the past 15 years. Cancer treatments are often highly effective at targeting cancer cells but can
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New uses for aspirin … and other research BMJ (IF 105.7) Pub Date : 2024-03-28 Ann Robinson
Ann Robinson reviews the latest research The ancient Sumerians and Egyptians used willow bark containing salicylates to treat pain and fevers more than 3500 years ago. In 1897, Bayer chemist Felix Hoffmann synthesised the first aspirin tablet, and 70 years later John Vance explained that it works by inhibiting prostaglandins. Today, aspirin remains one of the most widely used drugs worldwide and new
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Racism and misogyny persist in digital health BMJ (IF 105.7) Pub Date : 2024-03-28 Shera Chok
Frank Hester’s alleged comments are a stark reminder of the need to tackle racism and misogyny in the NHS and health technology industry Two weeks ago, the Guardian reported that in 2019, Frank Hester, chief executive of the Phoenix Partnership, and the conservative party’s biggest donor, said that: “It’s like trying not to be racist but you see Diane Abbott on TV, and you just want to hate all black
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Dark days for the Royal College of Physicians of London BMJ (IF 105.7) Pub Date : 2024-03-28 Trish Greenhalgh
Trish Greenhalgh says an urgent inquiry is needed to investigate how the Royal College of Physicians of London has handled the debate on physician associates The Royal College of Physicians of London (RCP) was established over 500 years ago to uphold professional standards in medicine, but now seems bent on lowering them. Senior officers appear to have engaged in Orwellian tactics to try to push through
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What comes next after the extraordinary general meeting on physician associates at the RCP? BMJ (IF 105.7) Pub Date : 2024-03-28 Partha Kar, Louella Vaughan
On 13 March an extraordinary general meeting (EGM) of the Royal College of Physicians (RCP) debated five motions on the use of physician associates (PAs) in the NHS.1 Four of the motions, relating to their scope of practice, accountability, evaluation, and how PAs affect the training opportunities of doctors—not just those in formal training programmes—were supported by both the RCP and the Faculty
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Paul Wallace: GP and innovative alcohol researcher BMJ (IF 105.7) Pub Date : 2024-03-27 John Illman
Paul Wallace, emeritus David Cohen professor of primary healthcare, University College London (UCL), had a mantra: “GPs are experts in normality.” Unlike many hospital specialists, he explained, GPs were less prone to over-investigate and go down rabbit holes leading nowhere. Far removed from normal, his personal life determined much of what he did professionally. Wallace, his brother, Mark, and their
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Neville Eric Stebbings BMJ (IF 105.7) Pub Date : 2024-03-28 Simon Stebbings
Neville Eric Stebbings, who died at the age of 97, led a remarkable life that coincided with the early years of the NHS. Born in Nottingham, he left at 17 to train at St Bartholomew’s Hospital Medical School, London, amid the chaos of the blitz, which led to the evacuation of the medical school to Cambridge. He had fond memories of his time there. After qualifying he worked as a house officer at Barts
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Yellow plaques on the trunk and limbs BMJ (IF 105.7) Pub Date : 2024-03-28 Sheng-Wen Liu, Chih-Yu Chen
This image shows multiple yellow, itchy, well demarcated, oedematous, and blanchable plaques with erythematous rims on the trunk and limbs of a woman in her 80s (fig 1). The lesions appeared a few hours after initiation of a meropenem infusion for aspiration pneumonia …
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Light therapy for depression . . . and other stories BMJ (IF 105.7) Pub Date : 2024-03-28 British Medical Journal Publishing Group
Bright light therapy can be helpful for adults with seasonal depression and with non-seasonal depression too. It’s an approach that is safe and non-invasive and would be well suited to adolescents with depression—except that it doesn’t seem to work in this age group. A trial in four centres in Germany randomised young people with moderate or severe major depressive disorder either to bright light therapy
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Rotational training denies doctors a sense of stability BMJ (IF 105.7) Pub Date : 2024-03-28 Ellie Jackson, Harshit Kondapally
Best discusses the case for reform of rotational training.1 We can see the benefits of short rotations, particularly during the foundation years. This can give new doctors exposure to a variety of specialties and allow them to develop a range of clinical skills, albeit dependent on their specific rotations. A large portion of time in foundation years rotations is, however, spent learning quirks …
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It is time for a coalition against ultra-processed foods BMJ (IF 105.7) Pub Date : 2024-03-28 Richard M Hoffman
The formation of Action on Smoking and Health (ASH) by the Royal College of Physicians in 1971 to lobby and campaign for tobacco control was a major step forward in public health. Since poor diet has overtaken smoking as the leading killer in many Western countries, it may now be time for a coalition against ultra-processed foods (UPFs). The case for such a body is further advanced by the new umbrella
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Recent estimates of alcohol specific deaths support alcohol minimum unit pricing BMJ (IF 105.7) Pub Date : 2024-03-28 Grant M A Wyper, Lucie Giles, Clare Beeston, Tara Shivaji
Critics of alcohol minimum unit pricing (MUP) emphasise the overall increase in alcohol related deaths in Scotland since the policy was introduced.1 The final evaluation report on MUP in Scotland concluded that the policy had a positive effect on population level health outcomes and alcohol related health inequalities.2 The most robust population level evidence, based on data up to the end of 2020
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The AI bot will see you now: how technology is changing the doctor-patient relationship BMJ (IF 105.7) Pub Date : 2024-03-28 Gareth Iacobucci
With advancements such as artificial intelligence being hailed as the solution to healthcare workforce challenges and the mismatch between demand and supply, Gareth Iacobucci reports on how interactions between doctors and patients are changing At the Nuffield Trust’s 2024 summit in early March The BMJ hosted a panel discussion, at which experts discussed what the increasing reliance on and use of
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Distinct electrocardiographic findings of a drug-drug interaction BMJ (IF 105.7) Pub Date : 2024-03-28 Yubin Zhang, Tong Liu, Gan-Xin Yan
A man in his 80s presented to the emergency department with a one day history of light headedness, dyspnoea, poor appetite, and fatigue. He had a history of hypertension, chronic atrial fibrillation, and atrial flutter, and his drug history included warfarin, metoprolol, digoxin, and furosemide. He reported a fever after experiencing symptoms of an upper respiratory tract infection and had taken a
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The future of the NHS depends on its workforce BMJ (IF 105.7) Pub Date : 2024-03-27 Mary Dixon-Woods, Charlotte Summers, Matt Morgan, Kiran Patel
The future of the NHS depends on the people who work in it, so workforce stewardship should be a key priority Achieving a high quality, sustainable NHS is currently challenged by major workforce problems. Staff are the most significant element of NHS expenditure1 and its most important asset in providing care for NHS patients, but stewardship of the workforce is not optimised at policy or service level
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John Launer: Why we should all #sayhellotopatients BMJ (IF 105.7) Pub Date : 2024-03-27 John Launer
I’ve just had some imaging done at a hospital I attend. I had to wait on a trolley for about 15 minutes while other patients went in to have their own procedures done. As I waited, I noticed something remarkable: 20 or so people happened to walk past me during this time and, almost without exception, smiled and said hello. This included, so far as I could tell, radiographers and doctors, porters and
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The GMC’s future vision for medical training must be challenged BMJ (IF 105.7) Pub Date : 2024-03-27 David Oliver, Louella Vaughan
On 12 March the General Medical Council (GMC) published Our Vision for the Future of Medical Education and Training .1 This was accompanied by an explanatory blog from Colin Melville,2 the GMC’s medical director and director of education and standards, in which he queried whether the current system of undergraduate and postgraduate medical training was “fit for purpose” and suggested that “medical
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Hasan Khurshid Mazhari BMJ (IF 105.7) Pub Date : 2024-03-26 Mohsin Mazhari
Hasan Khurshid Mazhari moved from his native India to the UK in 1973. He moved to the UK in 1973 and did rotational jobs in various disciplines as a senior house officer at Whipton and Heavitree Hospital in Exeter; North Ormesby Hospital in Middlesbrough; and New Cross Hospital, Ryde County Hospital, and Whitecroft Hospital on the Isle of Wight. In between jobs, he obtained a diploma in tropical medicine
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David Lindsay Maxwell BMJ (IF 105.7) Pub Date : 2024-03-26 Colin Kennedy
David Lindsay Maxwell was born in Nairn, Scotland, the eldest son of a Black Watch officer who died when David was 11, leaving him with a strong sense of responsibility for his mother and younger siblings. He was blessed with academic and natural athletic abilities, attributes he wore lightly, almost to the point that he felt embarrassed to have them. He had a happy school life, winning a scholarship
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Ultra-processed foods and adverse health outcomes: other approaches and evidence needed to prove genuine causal effect BMJ (IF 105.7) Pub Date : 2024-03-26 Marcus Munafò
The association between consumption of ultra-processed food and adverse health outcomes seems to be established.1 As with most observational epidemiology, however, the key question is whether this reflects a causal relation. To do this, we need to go beyond ever larger studies, …
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Frontiers’ journals saw large scale retractions—where does that leave the publisher’s reputation with researchers? BMJ (IF 105.7) Pub Date : 2024-03-27 Brian Owens
Frontiers, like other for-profit open access publishers, has struggled with a perception it has low editorial standards and weak peer review. But is that true? Brian Owens reports In September 2023 Frontiers—one of the world’s largest open access scientific publishers, with a stable of 230 journals covering just about every field of science—retracted 38 papers.1 All had been linked to the “unethical
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Falls Prevention for Older Adults JAMA (IF 120.7) Pub Date : 2024-03-27 Peggy B. Leung, Jason T. Alexander, Karin E. Ouchida
This article summarizes a 2022 clinical practice guideline on falls prevention and management in older adults from the World Falls Guidelines Initiative.
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Risk Assessment and Prevention of Falls in Older Community-Dwelling Adults JAMA (IF 120.7) Pub Date : 2024-03-27 Cathleen S. Colón-Emeric, Cara L. McDermott, Deborah S. Lee, Sarah D. Berry
ImportanceFalls are reported by more than 14 million US adults aged 65 years or older annually and can result in substantial morbidity, mortality, and health care expenditures.ObservationsFalls result from age-related physiologic changes compounded by multiple intrinsic and extrinsic risk factors. Major modifiable risk factors among community-dwelling older adults include gait and balance disorders
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Health Equity Adjustment and Hospital Performance in the Medicare Value-Based Purchasing Program JAMA (IF 120.7) Pub Date : 2024-03-27 Michael Liu, Sahil Sandhu, Karen E. Joynt Maddox, Rishi K. Wadhera
ImportanceMedicare’s Hospital Value-Based Purchasing (HVBP) program will provide a health equity adjustment (HEA) to hospitals that have greater proportions of patients dually eligible for Medicare and Medicaid and that offer high-quality care beginning in fiscal year 2026. However, which hospitals will benefit most from this policy change and to what extent are unknown.ObjectiveTo estimate potential
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Comparison of the immunogenicity and protective efficacy of ACAM2000, MVA, and vectored subunit vaccines for Mpox in rhesus macaques Sci. Transl. Med. (IF 17.1) Pub Date : 2024-03-27 Catherine Jacob-Dolan, Darren Ty, David Hope, Katherine McMahan, Jinyan Liu, Olivia C. Powers, Catherine A. Cotter, Michela Sciacca, Cindy Wu, Erica Borducchi, Emily Bouffard, Hannah Richter, Jason Velasco, Elyse Teow, Mona Boursiquot, Anthony Cook, Karen Feliciano, Jake Yalley-Ogunro, Michael S. Seaman, Laurent Pessiant, Mark G. Lewis, Hanne Andersen, Bernard Moss, Dan H. Barouch
The 2022–2023 mpox outbreak triggered vaccination efforts using smallpox vaccines that were approved for mpox, including modified vaccinia Ankara (MVA; JYNNEOS), which is a safer alternative to live replicating vaccinia virus (ACAM2000). Here, we compare the immunogenicity and protective efficacy of JYNNEOS by the subcutaneous or intradermal routes, ACAM2000 by the percutaneous route, and subunit Ad35
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Attenuation of fibroblast activation and fibrosis by adropin in systemic sclerosis Sci. Transl. Med. (IF 17.1) Pub Date : 2024-03-27 Minrui Liang, Nicholas Dickel, Andrea-Hermina Györfi, Bilgesu SafakTümerdem, Yi-Nan Li, Aleix Rius Rigau, Chunguang Liang, Xuezhi Hong, Lichong Shen, Alexandru-Emil Matei, Thuong Trinh-Minh, Cuong Tran-Manh, Xiang Zhou, Ariella Zehender, Alexander Kreuter, Hejian Zou, Georg Schett, Meik Kunz, Jörg H. W. Distler
Fibrotic diseases impose a major socioeconomic challenge on modern societies and have limited treatment options. Adropin, a peptide hormone encoded by the energy homeostasis–associated ( ENHO ) gene, is implicated in metabolism and vascular homeostasis, but its role in the pathogenesis of fibrosis remains enigmatic. Here, we used machine learning approaches in combination with functional in vitro and
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The gut microbiota posttranslationally modifies IgA1 in autoimmune glomerulonephritis Sci. Transl. Med. (IF 17.1) Pub Date : 2024-03-27 Patrick J. Gleeson, Nicolas Benech, Jonathan Chemouny, Eleftheria Metallinou, Laureline Berthelot, Jennifer da Silva, Julie Bex-Coudrat, Erwan Boedec, Fanny Canesi, Carine Bounaix, Willy Morelle, Maryse Moya-Nilges, John Kenny, Liam O’Mahony, Loredana Saveanu, Bertrand Arnulf, Aurélie Sannier, Eric Daugas, François Vrtovsnik, Patricia Lepage, Harry Sokol, Renato C. Monteiro
Mechanisms underlying the disruption of self-tolerance in acquired autoimmunity remain unclear. Immunoglobulin A (IgA) nephropathy is an acquired autoimmune disease where deglycosylated IgA1 (IgA subclass 1) auto-antigens are recognized by IgG auto-antibodies, forming immune complexes that are deposited in the kidneys, leading to glomerulonephritis. In the intestinal microbiota of patients with IgA
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Fixed-dose combination therapy for the prevention of atherosclerotic cardiovascular disease Nat. Med. (IF 82.9) Pub Date : 2024-03-26 Anubha Agarwal, Priya M. Mehta, Tyler Jacobson, Nilay S. Shah, Jiancheng Ye, JingJing Zhu, Q. Eileen Wafford, Ehete Bahiru, Angharad N. de Cates, Shah Ebrahim, Dorairaj Prabhakaran, Anthony Rodgers, Mark D. Huffman
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Risk factors associated with heatwave mortality in Chinese adults over 65 years Nat. Med. (IF 82.9) Pub Date : 2024-03-25 Di Xi, Linxin Liu, Min Zhang, Cunrui Huang, Katrin G. Burkart, Kristie Ebi, Yi Zeng, John S. Ji
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Promoting gender equity in the scientific and health workforce is essential to improve women’s health Nat. Med. (IF 82.9) Pub Date : 2024-03-22 Cristiani Vieira Machado, Cristina Araripe Ferreira, Maria Auxiliadora de Souza Mendes Gomes
Women’s health can be improved by increasing the representation of women in leadership roles in science, medicine and public health.
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Helen Salisbury: Practising at the top of your licence BMJ (IF 105.7) Pub Date : 2024-03-26 Helen Salisbury
Doctors in every branch of practice grumble about time wasted trying to fix malfunctioning printers or scouring the workplace for the right blood bottle or pathology form. A well organised health service would have staff on hand to help with such tasks, as it makes no sense to use your most highly trained staff on work that could safely be carried out by someone with less training. The idea of working
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Scarlett McNally: Retrofitting simple education into the NHS BMJ (IF 105.7) Pub Date : 2024-03-26 Scarlett McNally
I competed in a karate competition recently and found it a bit like surgery: you spend years perfecting technique and getting to know intuitively what might be effective with each person. The NHS needs to retain and value the experience and intuitive competence of doctors, other senior clinicians, and managers. Educating someone for autonomous practice and the ability to deal with complexity is hard
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Our leaders must urgently implement comprehensive policies to reduce harm caused by homelessness BMJ (IF 105.7) Pub Date : 2024-03-26 Michael Craig Watson, Karen E Neil
Homelessness is a global public health issue, and in many countries the number of homeless people is rising.1234 Williamson and Brunjes rightly draw our attention to some of the many causes of homelessness, the profound effects on people’s health, and some effective solutions.5 A range of factors can contribute to a person becoming homeless, including inadequate affordable housing, …
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Medical apprenticeships: using longitudinal integrated clerkships to tackle concerns of education and training BMJ (IF 105.7) Pub Date : 2024-03-26 Katie Webb, Ffion Williams, Stephen Riley, David Hirsh
Lynn’s article clarifies what is known about the development of medical apprenticeships.1 Little is currently known about specific educational approaches and oversight of medical apprenticeships in host practices or partner institutions. To meet calls for transformation and successful outcomes, medical education leaders should employ modern, evidence based, effective solutions. Longitudinal integrated
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Centralising human resources paperwork would improve rotational training BMJ (IF 105.7) Pub Date : 2024-03-26 Ann Sturdy
Best’s article highlights eight ways in which rotational training could be improved.1 I strongly support the last point: centralising contracts for specialty trainees to minimise the financial and other administration associated with new posts. I have recently completed my 14th set of human resources (HR) paperwork since I graduated over 11 years ago. This involves providing documents …
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Marmot Places: the areas taking a proactive local approach to health inequalities BMJ (IF 105.7) Pub Date : 2024-03-26 Erin Dean
Amid a “bleak” national picture, more than 40 local authorities across England and Wales have committed to making a long term difference to the health of their communities, writes Erin Dean Yorkshire GP Hasantha Jayasinghe knows exactly what health inequality looks like. He sees it in many forms, but what springs to mind most are the children with chronic, difficult-to-treat asthma he sees in his practice
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Northern Ireland’s government faces UK’s longest list of health woes BMJ (IF 105.7) Pub Date : 2024-03-26 Mark Dayan, Camille Oung
The new administration must take decisive action to improve health and care Healthcare is the largest public service in all UK nations1 and a totemic symbol of solidarity. Yet all four governments face deep concern over waiting times and healthcare staffing.23 None face a task quite as daunting as Northern Ireland’s newly formed government, now responsible for the health service with the longest waiting
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Correction BMJ (IF 105.7) Pub Date : 2024-03-26 British Medical Journal Publishing Group
In this article ( BMJ 2023;383:p2802, doi: …
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Common Oral Conditions JAMA (IF 120.7) Pub Date : 2024-03-26 Eric T. Stoopler, Alessandro Villa, Mohammed Bindakhil, David L. Ojeda Díaz, Thomas P. Sollecito
ImportanceDry mouth, oral candidiasis, and recurrent aphthous ulcers are 3 of the most common oral conditions that may be associated with patient discomfort, decreased quality of life, and morbidity.ObservationsIn a meta-analysis of 26 population-based cohort and cross-sectional studies, the global prevalence of dry mouth symptoms was 23% (95% CI, 18% to 28%), placing individuals at risk of oral candidiasis
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Testing pooled samples enables universal screening of congenital cytomegalovirus infection Nat. Med. (IF 82.9) Pub Date : 2024-03-21
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Dry eye disease management BMJ (IF 105.7) Pub Date : 2024-03-25 Margarita Safir, Gilad Twig, Michael Mimouni
### What you need to know Dry eye disease is common, with large cross sectional studies estimating a prevalence of 19-31% among the adult population123 and 6-23% among children.4 This condition is often associated with ocular discomfort and visual symptoms, and severity can range from mild occasional discomfort to sight threatening disease.5 This article offers an approach to identifying and managing
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Supporting health can help to boost employment BMJ (IF 105.7) Pub Date : 2024-03-25 David Finch
New policy direction and action can help reverse the trend of worsening health and declining employment in the UK, says David Finch The rise in the number of people claiming disability and health related benefits is unlikely to be a surprise to many GPs,1 who are often the first port of call for those with an emerging health problem. This situation has contributed to a wider recognition of the poor
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EXPRESSION OF CONCERN: Prioritising primary care patients with unexpected weight loss for cancer investigation: diagnostic accuracy study BMJ (IF 105.7) Pub Date : 2024-03-25 British Medical Journal Publishing Group
BMJ alerts readers to a problem with the content of this paper by Nicholson and colleagues ( BMJ 2020;370:m2651, doi:10.1136/bmj.m2651, published 13 August 2020). The authors of the paper recently identified an error in their approach to …
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Effectiveness and safety of drugs for obesity BMJ (IF 105.7) Pub Date : 2024-03-25 Kristina Henderson, Lewis, Caroline E Sloan, Daniel H Bessesen, David Arterburn
Recent publicity around the use of new antiobesity medications (AOMs) has focused the attention of patients and healthcare providers on the role of pharmacotherapy in the treatment of obesity. Newer drug treatments have shown greater efficacy and safety compared with older drug treatments, yet access to these drug treatments is limited by providers’ discomfort in prescribing, bias, and stigma around
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Why I . . . am a cricket umpire BMJ (IF 105.7) Pub Date : 2024-03-25 Kathy Oxtoby
GP Rodger Charlton talks to Kathy Oxtoby about the excitement and unpredictability of being a qualified cricket umpire Rodger Charlton is known as the “Spin Doctor” by members of his local village cricket team in recognition of his skills as a leg spin bowler on the pitch. Even when he’s not playing the game or chairing his local cricket club, he keeps his eyes fixed firmly on the ball as a qualified
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Provision of Medications for Self-Managed Abortion Before and After the Dobbs v Jackson Women’s Health Organization Decision JAMA (IF 120.7) Pub Date : 2024-03-25 Abigail R. A. Aiken, Elisa S. Wells, Rebecca Gomperts, James G. Scott
ImportanceThe Supreme Court decision in Dobbs v Jackson Women’s Health Organization overturned the right to choose abortion in the US, with at least 16 states subsequently implementing abortion bans or 6-week gestational limits. Prior research indicates that in the 6 months following Dobbs, approximately 32 360 fewer abortions were provided within the US formal health care setting. However, trends
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Selective Androgen Receptor Modulators—Transformative Drugs or Heralds of the Next Drug Epidemic? JAMA (IF 120.7) Pub Date : 2024-03-25 Henrik A. Hahamyan, Shehzad Basaria
This Viewpoint examines whether selective androgen receptor modulators have the potential to be transformative drugs or whether they herald the next drug epidemic.
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Understanding the Impacts of the Supreme Court Case FDA v Alliance for Hippocratic Medicine JAMA (IF 120.7) Pub Date : 2024-03-25 Eve Espey, Tiffany Hailstorks, Lisa Hofler
This Viewpoint outlines the potential effects of the Supreme Court case regarding mifepristone restrictions: a decision for the FDA would allow current dispensing, while ruling against the FDA would severely curtail access to reproductive health options.
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Differences in Donor Heart Acceptance by Race and Gender of Patients on the Transplant Waiting List JAMA (IF 120.7) Pub Date : 2024-03-25 Khadijah Breathett, Shannon M. Knapp, Sabra C. Lewsey, Selma F. Mohammed, Sula Mazimba, Shannon M. Dunlay, Albert Hicks, Onyedika J. Ilonze, Alanna A. Morris, Ryan J. Tedford, Monica M. Colvin, Richard C. Daly
ImportanceBarriers to heart transplant must be overcome prior to listing. It is unclear why Black men and women remain less likely to receive a heart transplant after listing than White men and women.ObjectiveTo evaluate whether race or gender of a heart transplant candidate (ie, patient on the transplant waiting list) is associated with the probability of a donor heart being accepted by the transplant
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The FDA in the Crosshairs—Science, Politics, and Abortion JAMA (IF 120.7) Pub Date : 2024-03-25 Holly Fernandez Lynch, Aaron S. Kesselheim
In this Viewpoint, the Supreme Court case FDA v AHM is used to illustrate the tension the FDA faces between science and politics, and state authority over abortion vs federal authority over which drugs may be marketed nationwide.
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A tough bioadhesive hydrogel supports sutureless sealing of the dural membrane in porcine and ex vivo human tissue Sci. Transl. Med. (IF 17.1) Pub Date : 2024-03-20 Kyle C. Wu, Benjamin R. Freedman, Phoebe S. Kwon, Matthew Torre, Daniel O. Kent, Wenya Linda Bi, David J. Mooney
Complete sequestration of central nervous system tissue and cerebrospinal fluid by the dural membrane is fundamental to maintaining homeostasis and proper organ function, making reconstruction of this layer an essential step during neurosurgery. Primary closure of the dura by suture repair is the current standard, despite facing technical, microenvironmental, and anatomic challenges. Here, we apply
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New allocation system for foundation training leaves doctors demoralised before they’ve even started work BMJ (IF 105.7) Pub Date : 2024-03-22 Nathanael Leaf
The newest recruits to the NHS already felt daunted about joining. Now, changes to how foundation training places are allocated risk taking away even more of their agency, writes Nathanael Leaf Earlier this month, I was among the first cohort of medical students to be assigned their foundation training post by the preference informed allocation system, which gives each applicant a random, computer