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Integrating spatial transcriptomics and single-cell RNA-sequencing reveals the alterations in epithelial cells during nodular formation in benign prostatic hyperplasia J. Transl. Med. (IF 7.4) Pub Date : 2024-04-23 Xiawei Fei, Jican Liu, Junyan Xu, Hongyan Jing, Zhonglin Cai, Jiasheng Yan, Zhenqi Wu, Huifeng Li, Zhong Wang, Yanting Shen
Proliferative nodular formation represents a characteristic pathological feature of benign prostatic hyperplasia (BPH) and serves as the primary cause for prostate volume enlargement and consequent lower urinary tract symptoms (LUTS). Its specific mechanism is largely unknown, although several cellular processes have been reported to be involved in BPH initiation and development and highlighted the
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Predictive significance of FGFR4 p.G388R polymorphism in metastatic colorectal cancer patients receiving trifluridine/tipiracil (TAS-102) treatment J. Transl. Med. (IF 7.4) Pub Date : 2024-04-22 Alessandro Ottaiano, Mariachiara Santorsola, Monica Ianniello, Anna Ceccarelli, Marika Casillo, Francesco Sabbatino, Nadia Petrillo, Marco Cascella, Francesco Caraglia, Carmine Picone, Francesco Perri, Roberto Sirica, Silvia Zappavigna, Guglielmo Nasti, Giovanni Savarese, Michele Caraglia
TAS-102 (Lonsurf®) is an oral fluoropyrimidine consisting of a combination of trifluridine (a thymidine analog) and tipiracil (a thymidine phosphorylation inhibitor). The drug is effective in metastatic colorectal cancer (mCRC) patients refractory to fluorouracil, irinotecan and oxaliplatin. This study is a real-world analysis, investigating the interplay of genotype/phenotype in relation to TAS-102
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Arginine-linked HPV-associated E7 displaying bacteria-derived outer membrane vesicles as a potent antigen-specific cancer vaccine J. Transl. Med. (IF 7.4) Pub Date : 2024-04-22 Suyang Wang, Chao-Cheng Chen, Ming-Hung Hu, Michelle Cheng, Hsin-Fang Tu, Ya-Chea Tsai, Jr-Ming Yang, T. C. Wu, Chuan-Hsiang Huang, Chien-Fu Hung
Bacteria-based cancer therapy have demonstrated innovative strategies to combat tumors. Recent studies have focused on gram-negative bacterial outer membrane vesicles (OMVs) as a novel cancer immunotherapy strategy due to its intrinsic properties as a versatile carrier. Here, we developed an Human Papillomavirus (HPV)-associated E7 antigen displaying Salmonella-derived OMV vaccine, utilizing a Poly(L-arginine)
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Assessment of cephalometric parameters and correlation with the severity of the obstructive sleep apnea syndrome J. Transl. Med. (IF 7.4) Pub Date : 2024-04-22 Eugenio Garofalo, Giuseppe Neri, Lucilla Maria Perri, Nicola Lombardo, Giovanna Piazzetta, Alessandro Antonelli, Eugenio Biamonte, Vincenzo Bosco, Caterina Battaglia, Corrado Pelaia, Francesco Manti, Annalisa Pitino, Giovanni Tripepi, Andrea Bruni, Michele Morelli, Amerigo Giudice, Federico Longhini
In individuals diagnosed with obstructive sleep apnea syndrome (OSAS), variations in craniofacial structure have been inconsistently documented, showing differing degrees of alteration between obese and nonobese patients. In addition, sleep disturbance has also been shown to induce disequilibrium in this population of patients. This pilot observational study aimed to assess craniofacial values in obese
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Correction to: COSMIC‑based mutation database enhances identification efficiency of HLA‑I immunopeptidome J. Transl. Med. (IF 7.4) Pub Date : 2024-04-22 Fangzhou Wang, Zhenpeng Zhang, Mingsong Mao, Yudai Yang, Ping Xu, Shichun Lu
Correction to: Journal of Translational Medicine (2024) 22:144 https://doi.org/10.1186/s12967-023-04821-0 Following publication of the original article [1], we have been notified that one of the authors’ last name was published incorrectly. It is now as follows: Fanghzou Wang1† It should be as follows: Fangzhou Wang 1† The original article was updated. Wang et al. (2024) COSMIC–based mutation database
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The redox-active defensive Selenoprotein T as a novel stress sensor protein playing a key role in the pathophysiology of heart failure J. Transl. Med. (IF 7.4) Pub Date : 2024-04-20 Anna De Bartolo, Teresa Pasqua, Naomi Romeo, Vittoria Rago, Ida Perrotta, Francesca Giordano, Maria Concetta Granieri, Alessandro Marrone, Rosa Mazza, Maria Carmela Cerra, Benjamin Lefranc, Jérôme Leprince, Youssef Anouar, Tommaso Angelone, Carmine Rocca
Maladaptive cardiac hypertrophy contributes to the development of heart failure (HF). The oxidoreductase Selenoprotein T (SELENOT) emerged as a key regulator during rat cardiogenesis and acute cardiac protection. However, its action in chronic settings of cardiac dysfunction is not understood. Here, we investigated the role of SELENOT in the pathophysiology of HF: (i) by designing a small peptide (PSELT)
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Mutational landscape of inflammatory breast cancer J. Transl. Med. (IF 7.4) Pub Date : 2024-04-18 François Bertucci, Florence Lerebours, Michele Ceccarelli, Arnaud Guille, Najeeb Syed, Pascal Finetti, José Adélaïde, Steven Van Laere, Anthony Goncalves, Patrice Viens, Daniel Birnbaum, Emilie Mamessier, Céline Callens, Davide Bedognetti
Inflammatory breast cancer (IBC) is the most pro-metastatic form of BC. Better understanding of its enigmatic pathophysiology is crucial. We report here the largest whole-exome sequencing (WES) study of clinical IBC samples. We retrospectively applied WES to 54 untreated IBC primary tumor samples and matched normal DNA. The comparator samples were 102 stage-matched non-IBC samples from TCGA. We compared
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Dissecting the shared genetic landscape of anxiety, depression, and schizophrenia J. Transl. Med. (IF 7.4) Pub Date : 2024-04-18 Yiming Tao, Rui Zhao, Bin Yang, Jie Han, Yongsheng Li
Numerous studies highlight the genetic underpinnings of mental disorders comorbidity, particularly in anxiety, depression, and schizophrenia. However, their shared genetic loci are not well understood. Our study employs Mendelian randomization (MR) and colocalization analyses, alongside multi-omics data, to uncover potential genetic targets for these conditions, thereby informing therapeutic and drug
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Implications of ZNF334 gene in lymph node metastasis of lung SCC: potential bypassing of cellular senescence J. Transl. Med. (IF 7.4) Pub Date : 2024-04-18 Khalil Khashei Varnamkhasti, Mehdi Moghanibashi, Sirous Naeimi
The primary goal of this work is to identify biomarkers associated with lung squamous cell carcinoma and assess their potential for early detection of lymph node metastasis. This study investigated gene expression in lymph node metastasis of lung squamous cell carcinoma using data from the Cancer Genome Atlas and R software. Protein-protein interaction networks, hub genes, and enriched pathways were
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The interaction of platelet-related factors with tumor cells promotes tumor metastasis J. Transl. Med. (IF 7.4) Pub Date : 2024-04-18 Jie Xue, Jianzhao Deng, Hongwei Qin, Songxia Yan, Zhen Zhao, Lifeng Qin, Jiao Liu, Haiyan Wang
Platelets not only participate in thrombosis and hemostasis but also interact with tumor cells and protect them from mechanical damage caused by hemodynamic shear stress and natural killer cell lysis, thereby promoting their colonization and metastasis to distant organs. Platelets can affect the tumor microenvironment via interactions between platelet-related factors and tumor cells. Metastasis is
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Discovery of a novel and highly selective JAK3 inhibitor as a potent hair growth promoter J. Transl. Med. (IF 7.4) Pub Date : 2024-04-18 Md Mehedi Hossain, Arfan Khalid, Zaheen Akhter, Sabra Parveen, Mir Owais Ayaz, Aadil Qadir Bhat, Neetu Badesra, Farheen Showket, Mohmmad Saleem Dar, Farhan Ahmed, Sumit Dhiman, Mukesh Kumar, Umed Singh, Razak Hussain, Pankaj Keshari, Ghulam Mustafa, Amit Nargorta, Neha Taneja, Somesh Gupta, Riyaz A. Mir, Aravind Singh Kshatri, Utpal Nandi, Nooruddin Khan, P. Ramajayan, Govind Yadav, Zabeer Ahmed, Parvinder
JAK-STAT signalling pathway inhibitors have emerged as promising therapeutic agents for the treatment of hair loss. Among different JAK isoforms, JAK3 has become an ideal target for drug discovery because it only regulates a narrow spectrum of γc cytokines. Here, we report the discovery of MJ04, a novel and highly selective 3-pyrimidinylazaindole based JAK3 inhibitor, as a potential hair growth promoter
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Short-chain fatty acid-producing bacterial strains attenuate experimental ulcerative colitis by promoting M2 macrophage polarization via JAK/STAT3/FOXO3 axis inactivation J. Transl. Med. (IF 7.4) Pub Date : 2024-04-18 Hailan Zhao, Youlian Zhou, Jing Xu, Yong Zhang, Hong Wang, Chong Zhao, Hongli Huang, Jing Yang, Chen Huang, Yingfei Li, Lisheng Wang, Yuqiang Nie
Patients with inflammatory bowel disease (IBD), dysbiosis, and immunosuppression who receive fecal microbiota transplantation (FMT) from healthy donors are at an increased risk of developing bacteremia. This study investigates the efficacy of a mixture of seven short-chain fatty acid (SCFA)-producing bacterial strains (7-mix), the resulting culture supernatant mixture (mix-sup), and FMT for treating
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The development of chimeric antigen receptor T-cells against CD70 for renal cell carcinoma treatment J. Transl. Med. (IF 7.4) Pub Date : 2024-04-18 Qinghui Xiong, Haiying Wang, Qiushuang Shen, Yan Wang, Xiujie Yuan, Guangyao Lin, Pengfei Jiang
In this study, we investigated CD70 as a promising target for renal cell carcinoma (RCC) therapy and developed a potent chimeric antigen receptor T (CAR-T) cells for potential clinical testing. CD70, found to be highly expressed in RCC tumors, was associated with decreased survival. We generated CAR-T cells expressing VHH sequence of various novel nanobodies from immunized alpaca and a single-chain
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Mesothelin-based CAR-T cells exhibit potent antitumor activity against ovarian cancer J. Transl. Med. (IF 7.4) Pub Date : 2024-04-18 Jing Guo, Xiaozhu Zeng, Yongjie Zhu, Dong Yang, Xudong Zhao
Ovarian cancer (OC) is characterized by its rapid growth and spread which, accompanied by a low 5-year survival rate, necessitates the development of improved treatments. In ovarian cancer, the selective overexpression of Mucin-16 (MUC16, CA125) in tumor cells highlights its potential as a promising target for developing anti-tumor therapies. However, the potential effectiveness of CAR-T cell therapy
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An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study J. Transl. Med. (IF 7.4) Pub Date : 2024-04-17 Yifei Cheng, Lang Wu, Junyi Xin, Shuai Ben, Silu Chen, Huiqin Li, Lingyan Zhao, Meilin Wang, Gong Cheng, Mulong Du
Early-onset prostate cancer (EOPC, ≤ 55 years) has a unique clinical entity harboring high genetic risk, but the majority of EOPC patients still substantial opportunity to be early-detected thus suffering an unfavorable prognosis. A refined understanding of age-based polygenic risk score (PRS) for prostate cancer (PCa) would be essential for personalized risk stratification. We included 167,517 male
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Tumor immune dysfunction and exclusion subtypes in bladder cancer and pan-cancer: a novel molecular subtyping strategy and immunotherapeutic prediction model J. Transl. Med. (IF 7.4) Pub Date : 2024-04-17 Kun Zheng, Youlong Hai, Hongqi Chen, Yukun Zhang, Xiaoyong Hu, Kai Ni
Molecular subtyping is expected to enable precise treatment. However, reliable subtyping strategies for clinical application remains defective and controversial. Given the significance of tumor immune dysfunction and exclusion (TIDE), we aimed to develop a novel TIDE-based subtyping strategy to guide personalized immunotherapy in the bladder cancer (BC). Transcriptome data of BC was used to evaluate
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Integrated lipid metabolomics and proteomics analysis reveal the pathogenesis of polycystic ovary syndrome J. Transl. Med. (IF 7.4) Pub Date : 2024-04-17 Yu Qian, Yun Tong, Yaqiong Zeng, Jingyu Huang, Kailu Liu, Ying Xie, Juan Chen, Mengya Gao, Li Liu, Juan Zhao, Yanli Hong, Xiaowei Nie
Polycystic ovary syndrome (PCOS) is an endocrinological and metabolic disorder that can lead to female infertility. Lipid metabolomics and proteomics are the new disciplines in systems biology aimed to discover metabolic pathway changes in diseases and diagnosis of biomarkers. This study aims to reveal the features of PCOS to explore its pathogenesis at the protein and metabolic level. We collected
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IL-33 regulates adipogenesis via Wnt/β-catenin/PPAR-γ signaling pathway in preadipocytes J. Transl. Med. (IF 7.4) Pub Date : 2024-04-17 Danning Xu, Siqi Zhuang, Hongzhi Chen, Mengjie Jiang, Ping Jiang, Qian Wang, Xuemei Wang, Ruohong Chen, Haoneng Tang, Lingli Tang
Interleukin-33 (IL-33), an emerging cytokine within the IL-1 family, assumes a pivotal function in the control of obesity. However, the specific mechanism of its regulation of obesity formation remains unclear. In this study, we found that the expression level of IL-33 increased in visceral adipose tissue in mice fed with a high-fat diet (HFD) compared with that in mice fed with a normal diet (ND)
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DB-1310, an ADC comprised of a novel anti-HER3 antibody conjugated to a DNA topoisomerase I inhibitor, is highly effective for the treatment of HER3-positive solid tumors J. Transl. Med. (IF 7.4) Pub Date : 2024-04-17 Xi Li, Jun Yao, Chen Qu, Lan Luo, Bing Li, Yu Zhang, Zhongyuan Zhu, Yang Qiu, Haiqing Hua
HER3 (ErbB3), a member of the human epidermal growth factor receptor family, is frequently overexpressed in various cancers. Multiple HER3-targeting antibodies and antibody–drug conjugates (ADCs) were developed for the solid tumor treatment, however none of HER3-targeting agent has been approved for tumor therapy yet. We developed DB-1310, a HER3 ADC composed of a novel humanized anti-HER3 monoclonal
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Prevalence of diverse colorectal polyps and risk factors for colorectal carcinoma in situ and neoplastic polyps J. Transl. Med. (IF 7.4) Pub Date : 2024-04-17 Xiaojuan Li, Mengting Hu, Zhangjun Wang, Mei Liu, Ying Chen
Most colorectal cancers originate from precancerous polyps. This study aimed to determine the prevalence of colorectal polyps with diverse pathological morphologies and to explore the risk factors for colorectal carcinoma in situ (CCS) and neoplastic polyps. Inpatients admitted from January 2018 to May 2023 were screened through the hospital information system. Polyps were classified according to pathological
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Landscapes of gut bacterial and fecal metabolic signatures and their relationship in severe preeclampsia J. Transl. Med. (IF 7.4) Pub Date : 2024-04-17 Xianxian Liu, Xiaoming Zeng, Xing Li, Siming Xin, Feng Zhang, Faying Liu, Yang Zeng, Jilin Wu, Yang Zou, Xinwei Xiong
Preeclampsia is a pregnancy-specific disease leading to maternal and perinatal morbidity. Hypertension and inflammation are the main characteristics of preeclampsia. Many factors can lead to hypertension and inflammation, including gut microbiota which plays an important role in hypertension and inflammation in humans. However, alterations to the gut microbiome and fecal metabolome, and their relationships
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Single-cell transcriptomics dissects the transcriptome alterations of hematopoietic stem cells in myelodysplastic neoplasms J. Transl. Med. (IF 7.4) Pub Date : 2024-04-17 Xiangzong Zeng, Yichen Wang, Min Dai, Wei Li, Qingtian Huang, Lingsha Qin, Yuquan Li, Yanwen Yan, Xiangjun Xue, Fang Yi, Wenhao Li, Langyu He, Qifa Liu, Ling Qi
Myelodysplastic neoplasms (MDS) are myeloid neoplasms characterized by disordered differentiation of hematopoietic stem cells and a predisposition to acute myeloid leukemia (AML). The underline pathogenesis remains unclear. In this study, the trajectory of differentiation and mechanisms of leukemic transformation were explored through bioinformatics analysis of single-cell RNA-Seq data from hematopoietic
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Machine learning and optical coherence tomography-derived radiomics analysis to predict persistent diabetic macular edema in patients undergoing anti-VEGF intravitreal therapy J. Transl. Med. (IF 7.4) Pub Date : 2024-04-16 Zhishang Meng, Yanzhu Chen, Haoyu Li, Yue Zhang, Xiaoxi Yao, Yongan Meng, Wen Shi, Youling Liang, Yuqian Hu, Dan Liu, Manyun Xie, Bin Yan, Jing Luo
Diabetic macular edema (DME) is a leading cause of vision loss in patients with diabetes. This study aimed to develop and evaluate an OCT-omics prediction model for assessing anti-vascular endothelial growth factor (VEGF) treatment response in patients with DME. A retrospective analysis of 113 eyes from 82 patients with DME was conducted. Comprehensive feature engineering was applied to clinical and
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Desmosomes in heart and skin: friends or foes? J. Transl. Med. (IF 7.4) Pub Date : 2024-04-16 Giuseppina Caiazzo, Rosa Redenta De Simone, Emanuele Monda, Ferdinando Barretta, Fabiana Uomo, Cristina Mazzaccara, Matteo Megna, Limongelli Giuseppe, Giulia Frisso
Arrhythmogenic cardiomyopathy (ACM) is a rare and heritable heart-muscle disease that predisposes to ventricular arrhythmias potentially leading to sudden cardiac death (SCD), especially in young patients. Genetic mutations have been identified in about 50% of ACM patients. The most common mutations affect the genes encoding the desmosomal proteins: plakophilin-2 (PKP2), desmoglein-2 (DSG2), desmoplakin
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Enhancing prediction accuracy of coronary artery disease through machine learning-driven genomic variant selection J. Transl. Med. (IF 7.4) Pub Date : 2024-04-16 Z. Alireza, M. Maleeha, M. Kaikkonen, V. Fortino
Machine learning (ML) methods are increasingly becoming crucial in genome-wide association studies for identifying key genetic variants or SNPs that statistical methods might overlook. Statistical methods predominantly identify SNPs with notable effect sizes by conducting association tests on individual genetic variants, one at a time, to determine their relationship with the target phenotype. These
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Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks J. Transl. Med. (IF 7.4) Pub Date : 2024-04-15 Jae-Seung Yun, Sang-Hyuk Jung, Su-Nam Lee, Seung Min Jung, Hong-Hee Won, Dokyoon Kim, Jin A. Choi
Glaucoma is a leading cause of worldwide irreversible blindness. Considerable uncertainty remains regarding the association between a variety of phenotypes and the genetic risk of glaucoma, as well as the impact they exert on the glaucoma development. We investigated the associations of genetic liability for primary open angle glaucoma (POAG) with a wide range of potential risk factors and to assess
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Application of high-precision 3D scanner in keloids evaluation to improve patients’ compliance: a questionnaire-based study J. Transl. Med. (IF 7.4) Pub Date : 2024-04-15 Huayi Wu, Zixi Jiang, Xiang Chen, Shuang Zhao, Zeyu Chen
To the Editor, Keloid is a prevalent benign skin neoplasm. Each year in the developed world, approximately 100 million people suffer from scar-related issues [1]. Current guidelines recommend that the combination of 5-fluorouracil (5-FU) and triamcinolone acetonide (TA) injections, administered in 3–5 treatment sessions (6–10 weeks), effectively reduces the elevation and redness of keloids [2, 3].
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Architecting the metabolic reprogramming survival risk framework in LUAD through single-cell landscape analysis: three-stage ensemble learning with genetic algorithm optimization J. Transl. Med. (IF 7.4) Pub Date : 2024-04-15 Xinti Sun, Minyu Nong, Fei Meng, Xiaojuan Sun, Lihe Jiang, Zihao Li, Peng Zhang
Recent studies have increasingly revealed the connection between metabolic reprogramming and tumor progression. However, the specific impact of metabolic reprogramming on inter-patient heterogeneity and prognosis in lung adenocarcinoma (LUAD) still requires further exploration. Here, we introduced a cellular hierarchy framework according to a malignant and metabolic gene set, named malignant & metabolism
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Quinic acid regulated TMA/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic J. Transl. Med. (IF 7.4) Pub Date : 2024-04-15 Qiao Jin, Chiyuan Zhang, Ran Chen, Luping Jiang, Hongli Li, Pengcui Wu, Liang Li
Quinic acid (QA) and its derivatives have good lipid-lowering and hepatoprotective functions, but their role in atherosclerosis remains unknown. This study attempted to investigate the mechanism of QA on atherogenesis in Apoe−/− mice induced by HFD. HE staining and oil red O staining were used to observe the pathology. The PCSK9, Mac-3 and SM22a expressions were detected by IHC. Cholesterol, HMGB1
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Stromal cartilage oligomeric matrix protein as a tumorigenic driver in ovarian cancer via Notch3 signaling and epithelial-to-mesenchymal transition J. Transl. Med. (IF 7.4) Pub Date : 2024-04-13 Gilar Gorji-Bahri, B. Madhu Krishna, Catharina Hagerling, Akira Orimo, Karin Jirström, Konstantinos S. Papadakos, Anna M. Blom
Cartilage oligomeric matrix protein (COMP), an extracellular matrix glycoprotein, is vital in preserving cartilage integrity. Further, its overexpression is associated with the aggressiveness of several types of solid cancers. This study investigated COMP’s role in ovarian cancer, exploring clinicopathological links and mechanistic insights. To study the association of COMP expression in cancer cells
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Nicotine restores olfactory function by activation of prok2R/Akt/FoxO3a axis in Parkinson’s disease J. Transl. Med. (IF 7.4) Pub Date : 2024-04-12 Qinglong Guo, Yi Wang, Liangchen Yu, Liao Guan, Xuefei Ji, Xiaohui Li, Gang Pang, Zhenhua Ren, Lei Ye, Hongwei Cheng
Olfactory dysfunction occurs frequently in Parkinson’s disease (PD). In this study, we aimed to explore the potential biomarkers and underlying molecular pathways of nicotine for the treatment of olfactory dysfunction in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced PD mice. MPTP was introduced into C57BL/6 male mice to generate a PD model. Regarding in vivo experiments, we performed
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Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology J. Transl. Med. (IF 7.4) Pub Date : 2024-04-12 Keming Lin, Baijin Xia, Xuemei Wang, Xin He, Mo Zhou, Yingtong Lin, Yidan Qiao, Rong Li, Qier Chen, Yuzhuang Li, Jinzhu Feng, Tao Chen, Cancan Chen, Xinyu Li, Hui Zhang, Lijuan Lu, Bingfeng Liu, Xu Zhang
Chimeric antigen receptor T (CAR-T) cell therapy, as an emerging anti-tumor treatment, has garnered extensive attention in the study of targeted therapy of multiple tumor-associated antigens in hepatocellular carcinoma (HCC). However, the suppressive microenvironment and individual heterogeneity results in downregulation of these antigens in certain patients’ cancer cells. Therefore, optimizing CAR-T
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Immersed in a reservoir of potential: amniotic fluid-derived extracellular vesicles J. Transl. Med. (IF 7.4) Pub Date : 2024-04-12 Ishara Atukorala, Natalie Hannan, Lisa Hui
This review aims to encapsulate the current knowledge in extracellular vesicles extracted from amniotic fluid and amniotic fluid derived stem/stromal cells. Amniotic fluid (AF) bathes the developing fetus, providing nutrients and protection from biological and mechanical dangers. In addition to containing a myriad of proteins, immunoglobulins and growth factors, AF is a rich source of extracellular
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THOC7-AS1/OCT1/FSTL1 axis promotes EMT and serves as a therapeutic target in cutaneous squamous cell carcinoma J. Transl. Med. (IF 7.4) Pub Date : 2024-04-11 Site Yu, Xu Cui, Situo Zhou, Yun Li, Wenjie Feng, Xiangjun Zhang, Yuhui Zhong, Pihong Zhang
THOC7-AS1 and FSTL1 expression are frequently upregulated in cutaneous squamous cell carcinoma (cSCC). However, their molecular biological mechanisms remain elusive and their potential as therapeutic targets needs urgent exploration. Human tissue samples were used to evaluate clinical parameters. In vitro and in vivo experiments assessed biological functions. Quantitative PCR, western blot, immunohistochemistry
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The integration of single-cell and bulk RNA-seq atlas reveals ERS-mediated acinar cell damage in acute pancreatitis J. Transl. Med. (IF 7.4) Pub Date : 2024-04-11 Kaige Yang, Rongli Xie, Guohui Xiao, Zhifeng Zhao, Min Ding, Tingyu Lin, Yiu Sing Tsang, Ying Chen, Dan Xu, Jian Fei
Acute pancreatitis (AP) is a clinically common acute abdominal disease, whose pathogenesis remains unclear. The severe patients usually have multiple complications and lack specific drugs, leading to a high mortality and poor outcome. Acinar cells are recognized as the initial site of AP. However, there are no precise single-cell transcriptomic profiles to decipher the landscape of acinar cells during
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Increased risk of psychiatric disorder in patients with hearing loss: a nationwide population-based cohort study J. Transl. Med. (IF 7.4) Pub Date : 2024-04-10 Qun-Yi Nian, Chun-An Cheng, Li-Hsiang Cheng, Yuan-Yung Lin, Chin-Hung Wang, Wu-Chien Chien, Yueng-Hsiang Chu, Cheng-Ping Shih, Chao-Yin Kuo, Hsin-Chien Chen, Jih-Chin Lee, Chi-Hsiang Chung, Wei-Chuan Shangkuan, Hung-Che Lin
Hearing loss has been shown to be a risk factor for psychiatric disorders. In addition, long-term hearing loss is associated with increased hospitalization and mortality rates; however, the increased risk and duration of effect of hearing loss in combination with other chronic diseases on each psychiatric disorder are still not clearly defined. The purpose of this article is to clarify the risk of
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Lack of shared neoantigens in prevalent mutations in cancer J. Transl. Med. (IF 7.4) Pub Date : 2024-04-10 Concetta Ragone, Beatrice Cavalluzzo, Angela Mauriello, Maria Tagliamonte, Luigi Buonaguro
Tumors are mostly characterized by genetic instability, as result of mutations in surveillance mechanisms, such as DNA damage checkpoint, DNA repair machinery and mitotic checkpoint. Defect in one or more of these mechanisms causes additive accumulation of mutations. Some of these mutations are drivers of transformation and are positively selected during the evolution of the cancer, giving a growth
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Association of circulating biomarkers with illness severity measures differentiates myalgic encephalomyelitis/chronic fatigue syndrome and post-COVID-19 condition: a prospective pilot cohort study J. Transl. Med. (IF 7.4) Pub Date : 2024-04-10 Joan Carles Domingo, Federica Battistini, Begoña Cordobilla, Maria Cleofé Zaragozá, Ramón Sanmartin-Sentañes, Jose Alegre-Martin, Trinitat Cambras, Jesus Castro-Marrero
Accumulating evidence suggests that autonomic dysfunction and persistent systemic inflammation are common clinical features in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID. However, there is limited knowledge regarding their potential association with circulating biomarkers and illness severity in these conditions. This single-site, prospective, cross-sectional, pilot
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Longitudinal study of the impact of the COVID-19 pandemic on diet and physical activity among Latinos of Mexican ancestry J. Transl. Med. (IF 7.4) Pub Date : 2024-04-09 Giovanna Muscogiuri, Lindsay Kohler, Oscar Parra, Lisa Soltani, Douglas Spegman, Dawn Coletta, Lawrence J. Mandarino
The COVID-19 pandemic caused societal disruption in the United States and most of the world, affecting many aspects of life, including healthcare and health-related behaviors such as diet, food security, and physical activity. Communities with economic and health disparities may have been particularly affected. This study was undertaken to determine how conditions in the early pandemic (January, 2021–February
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In situ chemoimmunotherapy hydrogel elicits immunogenic cell death and evokes efficient antitumor immune response J. Transl. Med. (IF 7.4) Pub Date : 2024-04-09 Qin Liu, Rui Xu, Jingwen Shen, Yaping Tao, Jingyi Shao, Yaohua Ke, Baorui Liu
Chemoimmunotherapy has shown promising advantages of eliciting immunogenic cell death and activating anti-tumor immune responses. However, the systemic toxicity of chemotherapy and tumor immunosuppressive microenvironment limit the clinical application. Here, an injectable sodium alginate hydrogel (ALG) loaded with nanoparticle albumin-bound-paclitaxel (Nab-PTX) and an immunostimulating agent R837
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Overexpression of TNFSF11 reduces GPX4 levels and increases sensitivity to ferroptosis inducers in lung adenocarcinoma J. Transl. Med. (IF 7.4) Pub Date : 2024-04-09 Zizhen Li, Wenhua Lu, Feng Yin, Peiting Zeng, Heping Li, Amin Huang
Lung adenocarcinoma (LUAD), the most common and lethal subtype of lung cancer, continues to be a major health concern worldwide. Despite advances in targeted and immune therapies, only a minority of patients derive substantial benefits. As a result, the urgent need for novel therapeutic strategies to improve lung cancer treatment outcomes remains undiminished. In our study, we employed the TIMER database
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Liposomes, transfersomes and niosomes: production methods and their applications in the vaccinal field J. Transl. Med. (IF 7.4) Pub Date : 2024-04-09 Domenico Riccardi, Lucia Baldino, Ernesto Reverchon
One of the most effective strategies to fight viruses and handle health diseases is vaccination. Recent studies and current applications are moving on antigen, DNA and RNA-based vaccines to overcome the limitations related to the conventional vaccination strategies, such as low safety, necessity of multiple injection, and side effects. However, due to the instability of pristine antigen, RNA and DNA
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SIRPB1 regulates inflammatory factor expression in the glioma microenvironment via SYK: functional and bioinformatics insights J. Transl. Med. (IF 7.4) Pub Date : 2024-04-09 Ren Geng, Yao Zhao, Wanzhen Xu, Xiaoshan Ma, Yining Jiang, Xuefei Han, Liyan Zhao, Yunqian Li
SIRPB1 expression is upregulated in various tumor types, including gliomas, and is known to contribute to tumor progression; nevertheless, its function in the immune milieu of gliomas is still mainly unknown. This study, we analyzed 1152 normal samples from the GTEx database and 670 glioma samples from the TCGA database to investigate the relationship between the expression of SIRPB1 and clinicopathological
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Wnt, glucocorticoid and cellular prion protein cooperate to drive a mesenchymal phenotype with poor prognosis in colon cancer J. Transl. Med. (IF 7.4) Pub Date : 2024-04-08 Sophie Mouillet-Richard, Angélique Gougelet, Bruno Passet, Camille Brochard, Delphine Le Corre, Caterina Luana Pitasi, Camille Joubel, Marine Sroussi, Claire Gallois, Julien Lavergne, Johan Castille, Marthe Vilotte, Nathalie Daniel-Carlier, Camilla Pilati, Aurélien de Reyniès, Fatima Djouadi, Sabine Colnot, Thierry André, Julien Taieb, Jean-Luc Vilotte, Béatrice Romagnolo, Pierre Laurent-Puig
The mesenchymal subtype of colorectal cancer (CRC), associated with poor prognosis, is characterized by abundant expression of the cellular prion protein PrPC, which represents a candidate therapeutic target. How PrPC is induced in CRC remains elusive. This study aims to elucidate the signaling pathways governing PrPC expression and to shed light on the gene regulatory networks linked to PrPC. We performed
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Melanocytes in regenerative medicine applications and disease modeling J. Transl. Med. (IF 7.4) Pub Date : 2024-04-08 Kelly Coutant, Brice Magne, Karel Ferland, Aurélie Fuentes-Rodriguez, Olivier Chancy, Andrew Mitchell, Lucie Germain, Solange Landreville
Melanocytes are dendritic cells localized in skin, eyes, hair follicles, ears, heart and central nervous system. They are characterized by the presence of melanosomes enriched in melanin which are responsible for skin, eye and hair pigmentation. They also have different functions in photoprotection, immunity and sound perception. Melanocyte dysfunction can cause pigmentary disorders, hearing and vision
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CDC45 promotes the stemness and metastasis in lung adenocarcinoma by affecting the cell cycle J. Transl. Med. (IF 7.4) Pub Date : 2024-04-08 Yafeng Liu, Tao Han, Zhi Xu, Jing Wu, Jiawei Zhou, Jianqiang Guo, Rui Miao, Yingru Xing, Deyong Ge, Ying Bai, Dong Hu
This study aimed to assess the functions of cell division cycle protein 45 (CDC45) in Non-small cell lung cancer (NSCLC) cancer and its effects on stemness and metastasis. Firstly, differentially expressed genes related to lung cancer metastasis and stemness were screened by differential analysis and lasso regression. Then, in vitro, experiments such as colony formation assay, scratch assay, and transwell
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Publisher Correction to: An integrated metabo‑lipidomics profile of induced sputum for the identification of novel biomarkers in the differential diagnosis of asthma and COPD J. Transl. Med. (IF 7.4) Pub Date : 2024-04-05 Serena Correnti, Mariaimmacolata Preianò, Fabia Gamboni, Daniel Stephenson, Corrado Pelaia, Girolamo Pelaia, Rocco Savino, Angelo D’Alessandro, Rosa Terracciano
Correction to: Journal of Translational Medicine (2024) 22:301 https://doi.org/10.1186/s12967-024-05100-2 Following publication of the original article [1], we have been notified on the following publisher’s mistake in not marking the author as the corresponding author. It is now: Rosa Terracciano4 It should be: Rosa Terracciano4* Correnti et al. An integrated metabo–lipidomics profile of induced sputum
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Edge-based relative entropy as a sensitive indicator of critical transitions in biological systems J. Transl. Med. (IF 7.4) Pub Date : 2024-04-04 Renhao Hong, Yuyan Tong, Huisheng Liu, Pei Chen, Rui Liu
Disease progression in biosystems is not always a steady process but is occasionally abrupt. It is important but challenging to signal critical transitions in complex biosystems. In this study, based on the theoretical framework of dynamic network biomarkers (DNBs), we propose a model-free method, edge-based relative entropy (ERE), to identify temporal key biomolecular associations/networks that may
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Intestinal Piezo1 aggravates intestinal barrier dysfunction during sepsis by mediating Ca2+ influx J. Transl. Med. (IF 7.4) Pub Date : 2024-04-04 Zimeng Yan, Lei Niu, Shangyuan Wang, Chengjin Gao, Shuming Pan
Intestinal barrier dysfunction is a pivotal factor in sepsis progression. The mechanosensitive ion channel Piezo1 is associated with barrier function; however, its role in sepsis-induced intestinal barrier dysfunction remains poorly understood. The application of cecal ligation and puncture (CLP) modeling was performed on both mice of the wild-type (WT) variety and those with Villin-Piezo1flox/flox
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Development and validation of a model and nomogram for breast cancer diagnosis based on quantitative analysis of serum disease-specific haptoglobin N-glycosylation J. Transl. Med. (IF 7.4) Pub Date : 2024-04-04 Linrong Li, Yali Xu, Zhizhen Lai, Dan Li, Qiang Sun, Zhili Li, Yidong Zhou
A better diagnostic marker is in need to distinguish breast cancer from suspicious breast lesions. The abnormal glycosylation of haptoglobin has been documented to assist cancer diagnosis. This study aims to evaluate disease-specific haptoglobin (DSHp)-β N-glycosylation as a potential biomarker for breast cancer diagnosis. DSHp-β chains of 497 patients with suspicious breast lesions who underwent breast
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Systematic proteome-wide Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma J. Transl. Med. (IF 7.4) Pub Date : 2024-04-04 Long Zhang, Yajun Xiong, Jie Zhang, Yuying Feng, Aiguo Xu
Lung adenocarcinoma (LUAD) is the predominant histological subtype of lung cancer and the leading cause of cancer-related mortality. Identifying effective drug targets is crucial for advancing LUAD treatment strategies. This study employed proteome-wide Mendelian randomization (MR) and colocalization analyses. We collected data on 1394 plasma proteins from a protein quantitative trait loci (pQTL) study
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CD137+ and regulatory T cells as independent prognostic factors of survival in advanced non-oncogene addicted NSCLC patients treated with immunotherapy as first-line J. Transl. Med. (IF 7.4) Pub Date : 2024-04-03 Alain Gelibter, Angela Asquino, Lidia Strigari, Ilaria Grazia Zizzari, Lucrezia Tuosto, Fabio Scirocchi, Angelica Pace, Marco Siringo, Elisa Tramontano, Serena Bianchini, Filippo Bellati, Andrea Botticelli, Donatella Paoli, Daniele Santini, Marianna Nuti, Aurelia Rughetti, Chiara Napoletano
Immune checkpoint inhibitors (ICIs), administered alone or combined with chemotherapy, are the standard of care in advanced non-oncogene addicted Non-Small Cell Lung Cancer (NSCLC). Despite these treatments' success, most long-term survival benefit is restricted to approximately 20% of patients, highlighting the need to identify novel biomarkers to optimize treatment strategies. In several solid tumors
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Double-negative T cells ameliorate psoriasis by selectively inhibiting IL-17A-producing γδlow T cells J. Transl. Med. (IF 7.4) Pub Date : 2024-04-02 Yunxiong Wei, Guangyong Sun, Yang Yang, Mingyang Li, Shimeng Zheng, Xiyu Wang, Xinjie Zhong, Zihan Zhang, Xiaotong Han, Haiyan Cheng, Dong Zhang, Xueling Mei
Psoriasis is a chronic immune-mediated skin condition. Although biologic treatments are effective in controlling psoriasis, some patients do not respond or lose response to these therapies. Thus, new strategies for psoriasis treatment are still urgently needed. Double-negative T cells (DNT) play a significant immunoregulatory role in autoimmune diseases. In this study, we aimed to evaluate the protective
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Regulatory role of PI16 in autoimmune arthritis and intestinal inflammation: implications for Treg cell differentiation and function J. Transl. Med. (IF 7.4) Pub Date : 2024-04-02 Yuankai Sun, Shiyu Lin, Hui Wang, Lei Wang, Yulu Qiu, Feifei Zhang, Nannan Hao, Fang Wang, Wenfeng Tan
Regulatory T cells (Tregs) are crucial in maintaining immune homeostasis and preventing autoimmunity and inflammation. A proportion of Treg cells can lose Foxp3 expression and become unstable under inflammation conditions. The precise mechanisms underlying this phenomenon remain unclear. The PI16 gene knockout mice (PI16fl/flFoxp3Cre) in Treg were constructed, and the genotypes were identified. The
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Correlation of distribution characteristics and dynamic changes of gut microbiota with the efficacy of immunotherapy in EGFR-mutated non-small cell lung cancer J. Transl. Med. (IF 7.4) Pub Date : 2024-04-02 Wei-Chi Luo, Shi-Qi Mei, Zi-Jian Huang, Zhi-Hong Chen, Yi-Chen Zhang, Ming-Yi Yang, Jia-Qi Liu, Jing-Yan Xu, Xiao-Rong Yang, Ri-Wei Zhong, Li-Bo Tang, Lin-Xi Yin, Yu Deng, Ying-Long Peng, Chang Lu, Bao-Long Chen, Dong-Xian Ke, Hai-Yan Tu, Jin-Ji Yang, Chong-Rui Xu, Yi-Long Wu, Qing Zhou
The effects of gut microbiota and metabolites on the responses to immune checkpoint inhibitors (ICIs) in advanced epidermal growth factor receptor (EGFR) wild-type non-small cell lung cancer (NSCLC) have been studied. However, their effects on EGFR-mutated (EGFR +) NSCLC remain unknown. We prospectively recorded the clinicopathological characteristics of patients with advanced EGFR + NSCLC and assessed
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A redeemed strategy for molecular autopsy in unexplained infant deaths J. Transl. Med. (IF 7.4) Pub Date : 2024-04-02 Yuqi Yang, Haixin Li, Jingyu Zhao, Hui Huang, Bin Yu
The causes of child death are very complex and the diagnosis remains a significant challenge. Even through extensive investigation, about 10.5% of deaths cannot be clearly explained [1]. Unexplained deaths have become a leading cause, greatly blocking the scientific guidance of re-birth. Autopsy is considered an accurate method for investigating unexplained deaths. However, it is not acceptable for
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Complement networks in gene-edited pig xenotransplantation: enhancing transplant success and addressing organ shortage J. Transl. Med. (IF 7.4) Pub Date : 2024-04-02 Yinglin Yuan, Yuanyuan Cui, Dayue Zhao, Yuan Yuan, Yanshuang Zhao, Danni Li, Xiaomei Jiang, Gaoping Zhao
The shortage of organs for transplantation emphasizes the urgent need for alternative solutions. Xenotransplantation has emerged as a promising option due to the greater availability of donor organs. However, significant hurdles such as hyperacute rejection and organ ischemia–reperfusion injury pose major challenges, largely orchestrated by the complement system, and activated immune responses. The
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MicroRNA-21a-5p inhibition alleviates systemic sclerosis by targeting STAT3 signaling J. Transl. Med. (IF 7.4) Pub Date : 2024-04-01 Jin-Sil Park, Chongtae Kim, JeongWon Choi, Ha Yeon Jeong, Young-Mee Moon, Hoin Kang, Eun Kyung Lee, Mi-La Cho, Sung-Hwan Park
MicroRNA (miRNA)-21-5p participates in various biological processes, including cancer and autoimmune diseases. However, its role in the development of fibrosis in the in vivo model of systemic sclerosis (SSc) has not been reported. This study investigated the effects of miRNA-21a-5p overexpression and inhibition on SSc fibrosis using a bleomycin-induced SSc mouse model. A murine SSc model was induced
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Very low-calorie ketogenic diet (VLCKD): a therapeutic nutritional tool for acne? J. Transl. Med. (IF 7.4) Pub Date : 2024-03-31 Ludovica Verde, Evelyn Frias-Toral, Sara Cacciapuoti, Daniel Simancas-Racines, Matteo Megna, Giuseppina Caiazzo, Luca Potestio, Maria Maisto, Gian Carlo Tenore, Annamaria Colao, Silvia Savastano, Giovanna Muscogiuri, Luigi Barrea
Acne, a chronic inflammatory disease impacting the pilosebaceous unit, is influenced significantly by inflammation and oxidative stress, and is commonly associated with obesity. Similarly, obesity is also associated with increased inflammation and oxidation. The role of diet in acne remains inconclusive, but the very low-calorie ketogenic diet (VLCKD), known for weight loss and generating anti-inflammatory
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An integrated framework for prognosis prediction and drug response modeling in colorectal liver metastasis drug discovery J. Transl. Med. (IF 7.4) Pub Date : 2024-03-30 Xiuman Zhou, Yuzhen Qian, Chen Ling, Zhuoying He, Peishang Shi, Yanfeng Gao, Xinghua Sui
Colorectal cancer (CRC) is the third most prevalent cancer globally, and liver metastasis (CRLM) is the primary cause of death. Hence, it is essential to discover novel prognostic biomarkers and therapeutic drugs for CRLM. This study developed two liver metastasis-associated prognostic signatures based on differentially expressed genes (DEGs) in CRLM. Additionally, we employed an interpretable deep