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Development and validation of a new algorithm for improved cardiovascular risk prediction Nat. Med. (IF 82.9) Pub Date : 2024-04-18 Julia Hippisley-Cox, Carol A. C. Coupland, Mona Bafadhel, Richard E. K. Russell, Aziz Sheikh, Peter Brindle, Keith M. Channon
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Targeting KRAS in cancer Nat. Med. (IF 82.9) Pub Date : 2024-04-18 Anupriya Singhal, Bob T. Li, Eileen M. O’Reilly
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An Omicron-specific, self-amplifying mRNA booster vaccine for COVID-19: a phase 2/3 randomized trial Nat. Med. (IF 82.9) Pub Date : 2024-04-18 Amit Saraf, Rohan Gurjar, Swarnendu Kaviraj, Aishwarya Kulkarni, Durgesh Kumar, Ruta Kulkarni, Rashmi Virkar, Jayashri Krishnan, Anjali Yadav, Ekta Baranwal, Ajay Singh, Arjun Raghuwanshi, Praveen Agarwal, Laxman Savergave, Sanjay Singh
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The fasciola cinereum of the hippocampal tail as an interventional target in epilepsy Nat. Med. (IF 82.9) Pub Date : 2024-04-17 Ryan M. Jamiolkowski, Quynh-Anh Nguyen, Jordan S. Farrell, Ryan J. McGinn, David A. Hartmann, Jeff J. Nirschl, Mateo I. Sanchez, Vivek P. Buch, Ivan Soltesz
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Nicotine e-cigarettes: considerations for healthcare providers Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Benjamin A. Toll, Tracy T. Smith, Brian A. King
Tobacco use continues to be the leading cause of preventable disease and death in the United States. There are no safe tobacco products; however, the health risks for tobacco products exist on a continuum, with combustible products such as cigarettes being the most harmful. Decades of research have documented that cigarette smoking harms nearly every organ of the body; cigarette smoke contains nearly
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A framework for implementing patient-reported outcomes in clinical care: the PROTEUS-practice guide Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Norah L. Crossnohere, Nicola Anderson, Judith Baumhauer, Melanie Calvert, Rebecca Esparza, Sandi Gulbransen, Lotte Haverman, Yuchen Li, Carolyn Petersen, Ameeta Retzer, Christopher Sidey-Gibbons, Angela M. Stover, Elissa Thorner, Garrett Ursin, Galina Velikova, Elliott Sparkman Walker, Michael Brundage, Claire Snyder
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Placental IGFBP1 levels during early pregnancy and the risk of insulin resistance and gestational diabetes Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Marie-France Hivert, Frédérique White, Catherine Allard, Kaitlyn James, Sana Majid, François Aguet, Kristin G. Ardlie, Jose C. Florez, Andrea G. Edlow, Luigi Bouchard, Pierre-Étienne Jacques, S. Ananth Karumanchi, Camille E. Powe
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Prediction of tumor origin in cancers of unknown primary origin with cytology-based deep learning Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Fei Tian, Dong Liu, Na Wei, Qianqian Fu, Lin Sun, Wei Liu, Xiaolong Sui, Kathryn Tian, Genevieve Nemeth, Jingyu Feng, Jingjing Xu, Lin Xiao, Junya Han, Jingjie Fu, Yinhua Shi, Yichen Yang, Jia Liu, Chunhong Hu, Bin Feng, Yan Sun, Yunjun Wang, Guohua Yu, Dalu Kong, Meiyun Wang, Wencai Li, Kexin Chen, Xiangchun Li
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Transparent medical image AI via an image–text foundation model grounded in medical literature Nat. Med. (IF 82.9) Pub Date : 2024-04-16 Chanwoo Kim, Soham U. Gadgil, Alex J. DeGrave, Jesutofunmi A. Omiye, Zhuo Ran Cai, Roxana Daneshjou, Su-In Lee
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Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson’s disease Nat. Med. (IF 82.9) Pub Date : 2024-04-15 Gennaro Pagano, Kirsten I. Taylor, Judith Anzures Cabrera, Tanya Simuni, Kenneth Marek, Ronald B. Postuma, Nicola Pavese, Fabrizio Stocchi, Kathrin Brockmann, Hanno Svoboda, Dylan Trundell, Annabelle Monnet, Rachelle Doody, Paulo Fontoura, Geoffrey A. Kerchner, Patrik Brundin, Tania Nikolcheva, Azad Bonni
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Designer antibiotics by generative AI Nat. Med. (IF 82.9) Pub Date : 2024-04-12
Researchers developed an AI model that designs novel, synthesizable antibiotic compounds — several of which showed potent in vitro activity against priority pathogens.
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Why diversity is needed at every level of clinical trials, from participants to leaders Nat. Med. (IF 82.9) Pub Date : 2024-04-11 Khadijah Breathett
Diversity in clinical trials must be accompanied by justice and equity, including benefits for underrepresented participants, in order to boost population health.
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Functional precision medicine for pediatric cancers Nat. Med. (IF 82.9) Pub Date : 2024-04-11 M. Emmy M. Dolman, Paul G. Ekert
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Feasibility of functional precision medicine for guiding treatment of relapsed or refractory pediatric cancers Nat. Med. (IF 82.9) Pub Date : 2024-04-11 Arlet M. Acanda De La Rocha, Noah E. Berlow, Maggie Fader, Ebony R. Coats, Cima Saghira, Paula S. Espinal, Jeanette Galano, Ziad Khatib, Haneen Abdella, Ossama M. Maher, Yana Vorontsova, Cristina M. Andrade-Feraud, Aimee Daccache, Alexa Jacome, Victoria Reis, Baylee Holcomb, Yasmin Ghurani, Lilliam Rimblas, Tomás R. Guilarte, Nan Hu, Daria Salyakina, Diana J. Azzam
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Generative models improve fairness of medical classifiers under distribution shifts Nat. Med. (IF 82.9) Pub Date : 2024-04-10 Ira Ktena, Olivia Wiles, Isabela Albuquerque, Sylvestre-Alvise Rebuffi, Ryutaro Tanno, Abhijit Guha Roy, Shekoofeh Azizi, Danielle Belgrave, Pushmeet Kohli, Taylan Cemgil, Alan Karthikesalingam, Sven Gowal
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‘Inverse vaccines’ could treat autoimmune disease — from multiple sclerosis to celiac disease Nat. Med. (IF 82.9) Pub Date : 2024-04-10
Nature Medicine explores the latest translational and clinical research news, with clinical trials testing glycosylated autoantigens as immunotolerance therapies.
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Tackling heat-related mortality in aging populations Nat. Med. (IF 82.9) Pub Date : 2024-04-08 Josiah L. Kephart, Safiyyah M. Okoye
A large study of older adults in China points to physical and cognitive function — not age — as key predictors of heat-related mortality, highlighting the need for climate adaptation policies to prioritize accessibility across all age groups.
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Food is medicine: clinical trials show the health benefits of dietary interventions Nat. Med. (IF 82.9) Pub Date : 2024-04-08
Growing evidence shows that dietary interventions can be effective at treating or delaying some diseases, but further trials are needed for wider adoption.
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Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs Nat. Med. (IF 82.9) Pub Date : 2024-04-08 Adrienne Y. L. Chan, Le Gao, Miyuki Hsing-Chun Hsieh, Lars J. Kjerpeseth, Raquel Avelar, Tobias Banaschewski, Amy Hai Yan Chan, David Coghill, Jacqueline M. Cohen, Mika Gissler, Jeff Harrison, Patrick Ip, Øystein Karlstad, Wallis C. Y. Lau, Maarit K. Leinonen, Wing Cheong Leung, Tzu-Chi Liao, Johan Reutfors, Shih-Chieh Shao, Emily Simonoff, Kathryn Choon Beng Tan, Katja Taxis, Andrew Tomlin, Carolyn
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Continuous glucose monitoring and intrapersonal variability in fasting glucose Nat. Med. (IF 82.9) Pub Date : 2024-04-08 Smadar Shilo, Ayya Keshet, Hagai Rossman, Anastasia Godneva, Yeela Talmor-Barkan, Yaron Aviv, Eran Segal
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Personalized neoantigen vaccine and pembrolizumab in advanced hepatocellular carcinoma: a phase 1/2 trial Nat. Med. (IF 82.9) Pub Date : 2024-04-07 Mark Yarchoan, Edward J. Gane, Thomas U. Marron, Renzo Perales-Linares, Jian Yan, Neil Cooch, Daniel H. Shu, Elana J. Fertig, Luciane T. Kagohara, Gabor Bartha, Josette Northcott, John Lyle, Sarah Rochestie, Joann Peters, Jason T. Connor, Elizabeth M. Jaffee, Ildiko Csiki, David B. Weiner, Alfredo Perales-Puchalt, Niranjan Y. Sardesai
Programmed cell death protein 1 (PD-1) inhibitors have modest efficacy as a monotherapy in hepatocellular carcinoma (HCC). A personalized therapeutic cancer vaccine (PTCV) may enhance responses to PD-1 inhibitors through the induction of tumor-specific immunity. We present results from a single-arm, open-label, phase 1/2 study of a DNA plasmid PTCV (GNOS-PV02) encoding up to 40 neoantigens coadministered
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Elevating kidney disease on the global health stage Nat. Med. (IF 82.9) Pub Date : 2024-04-04
Global nephrology societies have called on the WHO and health communities to tackle the growing burden of chronic kidney disease, which has been under-recognized for too long.
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Author Correction: A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6–dependent B cell lymphomas Nat. Med. (IF 82.9) Pub Date : 2024-04-03 Leandro. C Cerchietti, Eloisi. C Lopes, Shao. Ning Yang, Katerina Hatzi, Karen. L Bunting, Lucas. A Tsikitas, Alka Mallik, Ana. I Robles, Jennifer Walling, Lyuba Varticovski, Rita Shaknovich, Kapil. N Bhalla, Gabriela Chiosis, Ari Melnick
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Systematic testing in cholera surveillance enhances vaccine impact and cost-effectiveness Nat. Med. (IF 82.9) Pub Date : 2024-04-03
Most suspected cholera cases are not tested for Vibrio cholerae. Integrating systematic testing into cholera surveillance systems, even with imperfect rapid diagnostic tests, could yield large gains in efficiency and cost savings in the geographic targeting of mass oral cholera vaccination campaigns.
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Large language models for reducing clinicians’ documentation burden Nat. Med. (IF 82.9) Pub Date : 2024-04-01 Kirk Roberts
Evaluation of a clinical summarization method based on GPT-4 suggests that such models might reduce the documentation burden on clinicians — but prospective evaluation with high-priority tasks will be the true test of its potential.
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Going the extra mile to increase vaccine uptake Nat. Med. (IF 82.9) Pub Date : 2024-03-28
Deployment of mobile vaccination teams to remote communities in Sierra Leone substantially increased COVID-19 vaccine uptake, and could potentially be bundled with other health interventions.
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Microplastics at heart of the problem Nat. Med. (IF 82.9) Pub Date : 2024-03-27
Patients with carotid artery plaque that contain microplastics and nanoplastics were found to be at higher risk of cardiovascular events and mortality than those in whom the particles were not detected.
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A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results Nat. Med. (IF 82.9) Pub Date : 2024-03-27 Amy R. Rappaport, Chrisann Kyi, Monica Lane, Meghan G. Hart, Melissa L. Johnson, Brian S. Henick, Chih-Yi Liao, Amit Mahipal, Ardaman Shergill, Alexander I. Spira, Jonathan W. Goldman, Ciaran D. Scallan, Desiree Schenk, Christine D. Palmer, Matthew J. Davis, Sonia Kounlavouth, Lindsey Kemp, Aaron Yang, Yaojun John Li, Molly Likes, Annie Shen, Gregory R. Boucher, Milana Egorova, Robert L. Veres, J.
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Combination treatment for immune-mediated HIV remission Nat. Med. (IF 82.9) Pub Date : 2024-03-26
In rhesus macaques, treatment with an IL-15 superagonist and broad neutralizing antibodies led to durable suppression of viremia after discontinuation of antiretroviral therapy.
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Fixed-dose combination therapy for the prevention of atherosclerotic cardiovascular disease Nat. Med. (IF 82.9) Pub Date : 2024-03-26 Anubha Agarwal, Priya M. Mehta, Tyler Jacobson, Nilay S. Shah, Jiancheng Ye, JingJing Zhu, Q. Eileen Wafford, Ehete Bahiru, Angharad N. de Cates, Shah Ebrahim, Dorairaj Prabhakaran, Anthony Rodgers, Mark D. Huffman
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Risk factors associated with heatwave mortality in Chinese adults over 65 years Nat. Med. (IF 82.9) Pub Date : 2024-03-25 Di Xi, Linxin Liu, Min Zhang, Cunrui Huang, Katrin G. Burkart, Kristie Ebi, Yi Zeng, John S. Ji
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Promoting gender equity in the scientific and health workforce is essential to improve women’s health Nat. Med. (IF 82.9) Pub Date : 2024-03-22 Cristiani Vieira Machado, Cristina Araripe Ferreira, Maria Auxiliadora de Souza Mendes Gomes
Women’s health can be improved by increasing the representation of women in leadership roles in science, medicine and public health.
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Testing pooled samples enables universal screening of congenital cytomegalovirus infection Nat. Med. (IF 82.9) Pub Date : 2024-03-21
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Off-label use of artificial intelligence models in healthcare Nat. Med. (IF 82.9) Pub Date : 2024-03-22 Meera Krishnamoorthy, Michael W. Sjoding, Jenna Wiens
In healthcare, many artificial intelligence models could be used in settings other than those for which they were approved. But such off-label use must include an empirical or mechanistic evaluation to ensure patient safety.
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Revealing clinical heterogeneity in a large brain bank cohort Nat. Med. (IF 82.9) Pub Date : 2024-03-20
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Towards a general-purpose foundation model for computational pathology Nat. Med. (IF 82.9) Pub Date : 2024-03-19 Richard J. Chen, Tong Ding, Ming Y. Lu, Drew F. K. Williamson, Guillaume Jaume, Andrew H. Song, Bowen Chen, Andrew Zhang, Daniel Shao, Muhammad Shaban, Mane Williams, Lukas Oldenburg, Luca L. Weishaupt, Judy J. Wang, Anurag Vaidya, Long Phi Le, Georg Gerber, Sharifa Sahai, Walt Williams, Faisal Mahmood
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How to support the transition to AI-powered healthcare Nat. Med. (IF 82.9) Pub Date : 2024-03-19
To make health systems more sustainable in the long-term, incentivize artificial intelligence (AI) and digital technologies that are grounded on careful testing and real-world validation.
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Neoadjuvant nivolumab or nivolumab plus LAG-3 inhibitor relatlimab in resectable esophageal/gastroesophageal junction cancer: a phase Ib trial and ctDNA analyses Nat. Med. (IF 82.9) Pub Date : 2024-03-19 Ronan J. Kelly, Blair V. Landon, Ali H. Zaidi, Dipika Singh, Jenna V. Canzoniero, Archana Balan, Russell K. Hales, K. Ranh Voong, Richard J. Battafarano, Blair A. Jobe, Stephen C. Yang, Stephen Broderick, Jinny Ha, Kristen A. Marrone, Gavin Pereira, Nisha Rao, Aryan Borole, Katerina Karaindrou, Zineb Belcaid, James R. White, Suqi Ke, Ali I. Amjad, Benny Weksler, Eun Ji Shin, Elizabeth Thompson, Kellie
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A visual-language foundation model for computational pathology Nat. Med. (IF 82.9) Pub Date : 2024-03-19 Ming Y. Lu, Bowen Chen, Drew F. K. Williamson, Richard J. Chen, Ivy Liang, Tong Ding, Guillaume Jaume, Igor Odintsov, Long Phi Le, Georg Gerber, Anil V. Parwani, Andrew Zhang, Faisal Mahmood
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Heterogeneity and predictors of the effects of AI assistance on radiologists Nat. Med. (IF 82.9) Pub Date : 2024-03-19 Feiyang Yu, Alex Moehring, Oishi Banerjee, Tobias Salz, Nikhil Agarwal, Pranav Rajpurkar
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The health risks of extreme neoliberal politics in Argentina Nat. Med. (IF 82.9) Pub Date : 2024-03-19
Discover the world’s best science and medicine | Nature.com
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New AI regulation in the EU seeks to reduce risk without assessing public benefit Nat. Med. (IF 82.9) Pub Date : 2024-03-18 Barbara Prainsack, Nikolaus Forgó
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A timeline of biomarker changes before Alzheimer’s disease Nat. Med. (IF 82.9) Pub Date : 2024-03-15
Longitudinal data from the China Cognition and Aging Study map the sequential biomarker changes that begin almost two decades before clinical onset of Alzheimer’s disease.
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Telehealth enables safe medication abortion in shifting health and legal contexts Nat. Med. (IF 82.9) Pub Date : 2024-03-15 Dana M. Johnson, Abigail R. A. Aiken, Terri-Ann Thompson
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Prolonged benefits of bariatric surgery for patients with Type 2 Diabetes Nat. Med. (IF 82.9) Pub Date : 2024-03-15
People with type 2 diabetes who underwent bariatric surgery compared to medical or lifestyle interventions had better long-term outcomes, such as greater diabetes remission and less reliance on medication.
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Self-help mobile messaging intervention for depression among older adults in resource-limited settings: a randomized controlled trial Nat. Med. (IF 82.9) Pub Date : 2024-03-14 Marcia Scazufca, Carina Akemi Nakamura, Nadine Seward, Thiago Vinicius Nadaleto Didone, Felipe Azevedo Moretti, Marcelo Oliveira da Costa, Caio Hudson Queiroz de Souza, Gabriel Macias de Oliveira, Monica Souza dos Santos, Luara Aragoni Pereira, Mariana Mendes de Sá Martins, Pepijn van de Ven, William Hollingworth, Tim J. Peters, Ricardo Araya
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Acquired blood mutations cause acute kidney injury via dysregulated inflammation Nat. Med. (IF 82.9) Pub Date : 2024-03-13
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Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results Nat. Med. (IF 82.9) Pub Date : 2024-03-13 Stephen J. Bagley, Meghan Logun, Joseph A. Fraietta, Xin Wang, Arati S. Desai, Linda J. Bagley, Ali Nabavizadeh, Danuta Jarocha, Rene Martins, Eileen Maloney, Lester Lledo, Carly Stein, Amy Marshall, Rachel Leskowitz, Julie K. Jadlowsky, Shannon Christensen, Bike Su Oner, Gabriela Plesa, Andrea Brennan, Vanessa Gonzalez, Fang Chen, Yusha Sun, Whitney Gladney, David Barrett, MacLean P. Nasrallah, Wei-Ting
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Mpox continues to spread in Africa and threatens global health security Nat. Med. (IF 82.9) Pub Date : 2024-03-12 Kyeng Mercy, Bethelhem Tibebu, Mosoka Fallah, Nuno R. Faria, Nicaise Ndembi, Yenew Kebede Tebeje
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Identification of clinical disease trajectories in neurodegenerative disorders with natural language processing Nat. Med. (IF 82.9) Pub Date : 2024-03-12 Nienke J. Mekkes, Minke Groot, Eric Hoekstra, Alyse de Boer, Ekaterina Dagkesamanskaia, Sander Bouwman, Sophie M. T. Wehrens, Megan K. Herbert, Dennis D. Wever, Annemieke Rozemuller, Bart J. L. Eggen, Inge Huitinga, Inge R. Holtman
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How AI-powered handheld devices are boosting disease diagnostics - from cancer to dermatology Nat. Med. (IF 82.9) Pub Date : 2024-03-12
Nature Medicine explores the latest translational and clinical research news, with FDA approval of an AI-assisted optical reader to help in the diagnosis of skin cancer.
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MEGA CRISPR rejuvenates exhausted CAR T cells Nat. Med. (IF 82.9) Pub Date : 2024-03-11
MEGA is a new CRISPR-based RNA-editing platform with the ability to enhance the fitness of CAR T cells; it may also overcome certain limitations of conventional DNA-targeting CRISPR–Cas9 systems.
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Developing a conceptual framework for the early adoption of healthcare technologies in hospitals Nat. Med. (IF 82.9) Pub Date : 2024-03-08 Sheena Visram, Yvonne Rogers, Neil J. Sebire
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Restocking the tuberculosis drug arsenal Nat. Med. (IF 82.9) Pub Date : 2024-03-08 Eric L. Nuermberger, Richard E. Chaisson
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Steatotic liver disease: a new name to reflect the combined role of alcohol and metabolic dysfunction Nat. Med. (IF 82.9) Pub Date : 2024-03-08 Aleksander Krag, Mary E. Rinella
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Sex-specific genetic architecture of blood pressure Nat. Med. (IF 82.9) Pub Date : 2024-03-08 Min-Lee Yang, Chang Xu, Trisha Gupte, Thomas J. Hoffmann, Carlos Iribarren, Xiang Zhou, Santhi K. Ganesh
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Implementation of pooled saliva tests for universal screening of cCMV infection Nat. Med. (IF 82.9) Pub Date : 2024-03-08 Lior Merav, Noa Ofek Shlomai, Esther Oiknine-Djian, Orit Caplan, Ayala Livneh, Tal Sido, Amir Peri, Aviad Shtoyer, Eden Amir, Kerem Ben Meir, Yutti Daitch, Mila Rivkin, Esther Kripper, Irit Fogel, Hadar Horowitz, Sraya Greenberger, Mevaseret Cohen, Miriam Geal-Dor, Oren Gordon, Diana Averbuch, Zivanit Ergaz-Shaltiel, Smadar Eventov Friedman, Dana G. Wolf, Moran Yassour
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Self-care interventions for women’s health and well-being Nat. Med. (IF 82.9) Pub Date : 2024-03-07 Manjulaa Narasimhan, James R. Hargreaves, Carmen H. Logie, Quarraisha Abdool-Karim, Mandip Aujla, Jonathan Hopkins, Jane Cover, Olive Sentumbwe-Mugisa, Allan Maleche, Kate Gilmore
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Polygenic risk scores, radiation treatment exposures and subsequent cancer risk in childhood cancer survivors Nat. Med. (IF 82.9) Pub Date : 2024-03-07 Todd M. Gibson, Danielle M. Karyadi, Stephen W. Hartley, Michael A. Arnold, Amy Berrington de Gonzalez, Miriam R. Conces, Rebecca M. Howell, Vidushi Kapoor, Wendy M. Leisenring, Joseph P. Neglia, Joshua N. Sampson, Lucie M. Turcotte, Stephen J. Chanock, Gregory T. Armstrong, Lindsay M. Morton