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Risk factors for resistant gram-positive bacteremia in febrile neutropenic patients with cancer J. Infect. Chemother. (IF 2.2) Pub Date : 2024-03-20 Minkyeong Lee, Chan Mi Lee, Ja min Byun, Dong-Yeop Shin, Youngil Koh, Junshik Hong, Pyoeng Gyun Choe, Wan Beom Park, Nam Joong Kim, Sung-Soo Yoon, Myoung-don Oh, Chang Kyung Kang, Inho Kim
Gram-positive bacteria are frequently resistant to empirical beta‐lactams in febrile neutropenic patients with cancer. As microbiology and antibiotic susceptibility changes, we reevaluated the risk factors for resistant Gram-positive bacteremia in febrile neutropenic patients with cancer. Episodes of bacteremic febrile neutropenia in Seoul National University Hospital from July 2019 to June 2022 were
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A case of refractory disseminated subcutaneous abscess with intrahousehold transmission by a USA300-LV-like strain of PVL-positive community-acquired MRSA clone J. Infect. Chemother. (IF 2.2) Pub Date : 2024-03-18 Wakaki Kami, Motoo Baba, Tetsu Chinen, Jiro Fujita, Tetsuo Yamaguchi
A 44-year-old man with hypertension and dyslipidemia presented with pain in the buttocks. The patient was diagnosed with perianal ischiorectal fossa abscesses and cellulitis. He was subsequently diagnosed with a perineal subcutaneous abscess after a week, a right lower leg impetigo after a month, right periorchitis, a scrotal abscess, and Fournier's gangrene after two months. The patient was treated
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Potential risk factors for early acute kidney injury in patients treated with vancomycin J. Infect. Chemother. (IF 2.2) Pub Date : 2024-03-13 Aiju Endo, Kazumi Hanawa, Daiki Asakawa, Taiki Ishibe, Yu Nakane, Kaori Matsumoto, Yukihiro Hamada
The acute kidney injury (AKI) onset owing to vancomycin (VCM) is reported that depend on the area under the blood concentration-time curve (AUC) and occur comparison early phase (early AKI). This study aimed to investigate the occurrence of early AKI in patients treated with VCM and new indicators to avoid early AKI. Adult patients who received VCM treatment for more than 4 days and whose trough values
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Assessment of patients’ characteristics associated with the efficacy and safety of oral valganciclovir treatment for infants with symptomatic congenital cytomegalovirus disease J. Infect. Chemother. (IF 2.2) Pub Date : 2024-03-13 Yasumasa Kakei, Ichiro Morioka, Takumi Imai, Kotaro Itohara, Ikuko Yano, Naoto Takahashi, Tetsushi Yoshikawa, Hiroyuki Moriuchi, Yoshinori Ito, Kazumichi Fujioka, Akira Oka, Japanese Congenital Cytomegalovirus Study Group, Aya Okahashi, Nobuhiko Nagano, Midori Hijikata, Kazumasa Fuwa, Ryoji Aoki, Ayako Seimiya, Takayuki Imaizumi, Takuya Akimoto, Koichiro Hara, Daichi Katayama, Shinya Abe, Mariko Ashina
Insurance coverage for oral valganciclovir (VGCV) began in Japan in April 2023 on the basis of results, including our clinical trials for symptomatic congenital cytomegalovirus (CMV) disease. The VGCV treatment is available throughout Japan, so clinicians must consider the likelihood of hearing improvement and the possibility of neutropenia before dosing. We performed a substudy of an investigator-initiated
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Autochthonous Cryptococcus gattii genotype VGIIb infection in a Japanese patient with anti-granulocyte-macrophage colony-stimulating factor antibodies J. Infect. Chemother. (IF 2.2) Pub Date : 2024-03-12 Tsuyoshi Hamaguchi, Nobuaki Uchida, Michiyo Fujita-Nakata, Megumi Nakanishi, Yasuhiro Tsuchido, Miki Nagao, Yoshitsugu Iinuma, Masato Asahina
A 31-year-old Japanese man presented with cerebral and pulmonary cryptococcosis. () genotype VGIIb was detected in the patient's sputum and cerebrospinal fluid specimens. The serum levels of anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies were elevated in this patient, which has been associated with pulmonary alveolar proteinosis and is considered a risk factor for infection
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A systematic review and meta-analysis of antibiotic-loaded bone cement for prevention of deep surgical site infections following primary total joint replacement J. Infect. Chemother. (IF 2.2) Pub Date : 2024-03-12 Hideo Kato, Yukihiro Hamada, Shotaro Takano, Shinsuke Ikeda, Yoshinori Seto, Kazuhiko Matsushita, Koji Yamada, Katsufumi Uchiyama
The use of antibiotic-loaded bone cement (ALBC) as a mean for preventing deep surgical site infections (SSI) after total joint replacement is controversial. Therefore, we have conducted a meta-analysis to evaluate the prophylactic effect of ALBC for SSI prevention in patients undergoing arthroplasty. This study was conducted to revise treatment guidelines for MRSA infections in Japan. PubMed (Medline)
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Zinc deficiency is a potential risk factor for COVID-19 progression to pneumonia requiring oxygen therapy J. Infect. Chemother. (IF 2.2) Pub Date : 2024-03-08 Koji Fujita, Kazuki Ocho, Tomoka Kadowaki, Takashi Yorifuji, Hideharu Hagiya, Fumio Otsuka
Various risk factors for developing severe coronavirus disease 2019 (COVID-19) have been reported. However, studies on the nutritional-related risk factors are limited. In this study, we investigated the effects of serum zinc deficiency on the severity of COVID-19. The study included a total of 60 COVID-19 patients who were admitted to Tsuyama Chuo Hospital between March 2020 and April 2021. We divided
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Gallic acid promotes macrophage phagosome acidification and phagolysosome formation by activating NLRP3/mTOR signaling pathway J. Infect. Chemother. (IF 2.2) Pub Date : 2024-03-08 Yanqu Cai, Jinzhu Jiang, Chunhua Yue, Zhipeng Zhang, Wenbin Liu
Gallic acid (GA) has a good therapeutic effect in bacteriological inhibition and plays a variety of functions in maintaining the stability of the immune system. The aim of the present study was to investigate the effect of GA on the bactericidal activity of macrophages against (Vv). A cell counting kit-8 (CCK-8) assay was carried out to test the cytotoxicity of GA on J774A.1 cells. Concentration of
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Development of toluidine red particle agglutination-based turbidimetric immunoassay for anticardiolipin antibody detection in syphilis J. Infect. Chemother. (IF 2.2) Pub Date : 2024-03-07 Xi Chen, Chengyu Yuan, Biwen Wang, Mengni Guan, Xianyu Zheng
Serological tests of non-treponemal and treponemal types are the most frequently used for syphilis diagnosis. Nontreponemal tests are used to monitor disease activity. Toluidine red unheated serum test (TRUST), as one of nontreponemal tests, is generally applicable to hospitals at different levels. However, accurate judgment of TRUST results is inseparable from an experienced and accurate operator
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Molecular characterization of a carbon dioxide-dependent Proteus mirabilis small-colony variant isolated from a clinical specimen J. Infect. Chemother. (IF 2.2) Pub Date : 2024-03-03 Takehisa Matsumoto, Masayuki Hashimoto, Wen-Chun Huang, Ching-Hao Teng, Takahiko Niwa, Mariko Yamada, Tatsuya Negishi
Carbon dioxide-dependent has been isolated from clinical specimens. It is not clear whether mutations in carbonic anhydrase are responsible for the carbon dioxide dependence of . The pathogenicity of carbon dioxide-dependent also remains unclear. The purpose of this study was to determine the cause carbon dioxide dependence of and its pathogenicity. The DNA sequence of encoding carbonic anhydrase of
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Surveillance of antimicrobial awareness among patients visiting community pharmacies J. Infect. Chemother. (IF 2.2) Pub Date : 2024-03-02 Kosuke Hasegawa, Yuriko Matsumura, Tomoko Mori, Toshio Asakura, Hidemasa Nakaminami
Although antimicrobial resistance (AMR) measures have been progressing, cases of patients requesting their doctors to prescribe antimicrobial agents and patients mistakenly believing that these agents are effective against viruses occasionally occur. In the AMR action plan (2023–2027) in Japan, one of the primary goals are public awareness and education. However, public understanding of AMR and antimicrobial
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Antimicrobial photodynamic effect of the photosensitizer riboflavin, alone and in combination with colistin, against pandrug-resistant Pseudomonas aeruginosa clinical isolates J. Infect. Chemother. (IF 2.2) Pub Date : 2024-03-02 Ehsan Najari, Samin Zamani, Mehdi Sheikh Arabi, Abdollah Ardebili
Development of multi-, extensively-, and pandrug-resistant (MDR, XDR, and PDR) strains of remains a major problem in medical care. The present study evaluated the effect of antimicrobial photodynamic therapy (aPDT) as a monotherapy and in combination with colistin against isolates. Two isolates recovered from patients with respiratory tract infections were examined in this study. Minimum inhibitory
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Can the “Access” percentage assess the antibiotic use appropriateness? J. Infect. Chemother. (IF 2.2) Pub Date : 2024-03-02 Y, o, s, h, i, k, i, , K, u, s, a, m, a
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Clinical evaluation of a modified SARS-CoV-2 rapid molecular assay, ID NOW ™ COVID-19 2.0 J. Infect. Chemother. (IF 2.2) Pub Date : 2024-03-02 Yu Arakawa, Yoshie Nishida, Daisuke Sakanashi, Akiko Nakamura, Hirotoshi Ota, Shinji Tokuhiro, Hiroshige Mikamo, Yuka Yamagishi
In the diagnosis of coronavirus disease 2019 (COVID-19), several types of instruments and reagents for SARS-CoV-2 nucleic acid testing have been introduced to meet clinical needs. We evaluated the clinical performances of ID NOW™ COVID-19 2.0 (ID NOW™ 2.0), which is capable of detecting SARS-CoV-2 within 12 min as part of point-of-care testing (POCT). Patients who displayed COVID-19 related symptoms
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Caution when incorporating observational studies into a meta-analysis J. Infect. Chemother. (IF 2.2) Pub Date : 2024-03-02 Shungo Yamamoto
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Assessing the discriminability of PCR-based open reading frame typing versus single-nucleotide polymorphism analysis via draft whole-genome sequencing of methicillin-resistant Staphylococcus aureus in nosocomial transmission analysis J. Infect. Chemother. (IF 2.2) Pub Date : 2024-03-02 Shinji Ogihara, Tetsuo Yamaguchi, Takahiro Sato, Kotaro Aoki, Kohji Komori, Masakazu Sasaki, Hinako Murakami, Yoshikazu Ishii, Kazuhiro Tateda
Phylogenetic analysis based on single-nucleotide polymorphism (SNP)-based through whole-genome sequencing is recognized as the standard method for probing nosocomial transmission. However, the application of WGS is constrained by the high cost of equipment and the need for diverse analysis tools, which limits its widespread use in clinical laboratory settings. In Japan, the prevalent use of PCR-based
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Antimicrobial therapy and outcome of methicillin-resistant Staphylococcus aureus endocarditis: A retrospective multicenter study in Japan J. Infect. Chemother. (IF 2.2) Pub Date : 2024-03-01 Kotaro Mitsutake, Natsuki Shinya, Masafumi Seki, Takahiro Ohara, Kohei Uemura, Masato Fukunaga, Jun Sakai, Miki Nagao, Makoto Sata, Yohei Hamada, Hitoshi Kawasuji, Yoshihiro Yamamoto, Masashi Nakamatsu, Yusuke Koizumi, Hiroshige Mikamo, Akira Ukimura, Tetsuji Aoyagi, Toyomitsu Sawai, Takeshi Tanaka, Koichi Izumikawa, Yoko Takayama, Kiwamu Nakamura, Keiji Kanemitsu, Issei Tokimatsu, Kazuhiko Nakajima
MRSA (methicillin-resistant )-infective endocarditis (IE) is associated with high morbidity and mortality. This study aimed to assess data from patients with MRSA-IE across multiple facilities in Japan, with a specific focus on antimicrobial therapy and prognosis. This retrospective study enrolled patients with a confirmed diagnosis of IE attributed to MRSA, spanning the period from January 2015 to
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Determination of intracellular tenofovir-diphosphate and emtricitabine-triphosphate concentrations in dried blood spots for pre-exposure prophylaxis adherence J. Infect. Chemother. (IF 2.2) Pub Date : 2024-03-01 Kiyoto Tsuchiya, Yoshiharu Hayashi, Shoraku Ryu, Hieu Trung Tran, Misao Takano, Kazuko Tanaka, Daisuke Mizushima, Shinichi Oka, Hiroyuki Gatanaga, Akinobu Hamada
We measured the intracellular concentrations of tenofovir-diphosphate (TFV-DP) and emtricitabine-triphosphate (FTC-TP) in dried blood spots (DBS) for pre-exposure prophylaxis (PrEP) adherence using sensitive liquid chromatography–tandem mass spectrometry (LC–MS/MS). A total of 191 DBS were obtained from 85 participants who were receiving tenofovir disoproxil fumarate (TDF; 300 mg) and emtricitabine
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The epidemiology of pulmonary Mycobacterium abscessus species in Japanese population J. Infect. Chemother. (IF 2.2) Pub Date : 2024-03-01 Hiroaki Ihara, Kanami Kondo, Yuki Muto, Manami Haba, Hiroki Nakazawa, Tetsuya Handoh, Yuta Arai, Kohei Shibayama, Issei Sumiyoshi, Yusuke Ochi, Junko Watanabe, Satomi Takei, Ayako Nakamura, Yuichi Fujimoto, Shinsaku Togo, Kazuhisa Takahashi
species (MABS) is now a most virulent rapidly growing mycobacteria (RGM), and the rapid increase of MABS was recently observed worldwide, including in Japan. Thus, we gathered evidences of the presence of pulmonary MABS in Japanese population from Japanese articles. we searched studies that addressed the isolation of pulmonary non-tuberculous (NTM) or MABS from clinical respiratory specimens in Japan
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Evaluation of MALDI-TOF mass spectrometry coupled with ClinProTools as a rapid tool for toxin-producing Clostridioides difficile J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-28 Asami Nakayama, Yoshitomo Morinaga, Ryota Izuno, Keita Morikane, Katsunori Yanagihara
The performance of MALDI-TOF MS combined with analysis platform for identification of toxin-producing is yet to be known. Between August 2018 and September 2020, 61 isolates from stool specimens of patients with -associated diarrhea were analyzed using the MALDI Biotyper system. A toxin-producer detection model was developed using ClinProTools. The model was validated using 28 known strains that differed
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Chemoprotective and immunomodulatory potential of Lactobacillus reuteri against cadmium chloride-induced breast cancer in mice J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-28 Ayesha Sajjad, Shaukat Ali, Samaira Mumtaz, Muhammad Summer, Muhammad Adeel Farooq, Ali Hassan
The current study aimed to investigate the role of probiotic for the treatment and prevention of breast cancer. Breast cancer was induced by using Cadmium Chloride (Cd) (2 mg/kg) in group II. Tamoxifen was administered to group III. Group IV was treated with . Group V was treated with Cd for one month and divided into three subgroups including VA, VB, and VC which were treated with tamoxifen, , and
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Difference in the impact of coinfections and secondary infections on antibiotic use in patients hospitalized with COVID-19 between the Omicron-dominant period and the pre-Omicron period J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-28 Yasushi Murakami, Yasuhiro Nozaki, Mika Morosawa, Masanobu Toyama, Hitoshi Ogashiwa, Takashi Ueda, Kazuhiko Nakajima, Ryoya Tanaka, Yoshio Takesue
This study evaluated the effect of coinfections and/or secondary infections on antibiotic use in patients hospitalized with coronavirus disease 2019 (COVID-19). Days of therapy per 100 bed days (DOT) in a COVID-19 ward were compared between 2022 (Omicron period) and 2021 (pre-Omicron period). Antibiotics were categorized as antibiotics predominantly used for community-acquired infections (CAIs) and
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Factors affecting the antimicrobial changes during treatment for acute otitis media in Japan: A retrospective cohort study using classification and regression trees (CART) analysis J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-27 Masamitsu Kono, Daichi Murakami, Hideki Sakatani, Katsuya Okuda, Tetsuya Kinoshita, Masayoshi Hijiya, Takuro Iyo, Tatsuya Shiga, Yo-hei Morita, Koju Itahashi, Yuji Sasagawa, Yasuhiro Iwama, Tomohisa Yamaguchi, Muneki Hotomi
Factors that affect the change of first-line antimicrobial agents were investigated to further promote their appropriate use. This descriptive study used an electronic medical records database. Total 16,353 of the 199,896 patients enrolled between 1996 and 2019 met the inclusion criteria and formed the overall pediatric acute otitis media (AOM) cohort. The factors leading to the change in first-line
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Development of progressive multifocal leukoencephalopathy after cord blood transplantation in a patient with refractory angioimmunoblastic T-cell lymphoma J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-27 Masayuki Aiba, Kohei Okada, Takumi Funakoshi, Rintaro Nozu, Tomoki Takahashi, Shunsuke Ozu, Daisuke Hidaka, Reiki Ogasawara, Junichi Sugita, Masahiro Ogasawara, Naoki Kobayashi, Masahiro Imamura, Hirohiko Shizukawa, Shuichi Ota
A patient undergoing cord blood transplantation for refractory angioimmunoblastic T-cell lymphoma was subsequently managed with long-term immunosuppressants for chronic graft-versus-host disease (GVHD). On day 591 post-transplant, she exhibited disorientation and cognitive dysfunction. Magnetic resonance imaging (MRI) of the brain revealed two hyperintense foci in the white matter, suggestive of progressive
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Reviving Sternheimer stain: A single-center retrospective study to detect the diagnostic utility of urinary tract infections in the emergency department J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-20 Hikaru Nagatomi, Ryuichi Minoda Sada, Noriyuki Abe, Hirofumi Miyake, Hiroyuki Akebo
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Safety and antibody response of the BNT162b2 SARS-CoV-2 vaccine in children aged 5–11 years with underlying diseases: A prospective observational study J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-20 Takanori Funaki, Masaki Yamada, Kozue Miyake, Saki Ueno, Shota Myojin, Hiroyuki Aiba, Toshihiro Matsui, Chikara Ogimi, Hitoshi Kato, Isao Miyairi, Kensuke Shoji
Data on the safety and antibody response of the BNT162b2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccine in children aged 5–11 years with underlying diseases are limited. Thus, our study aimed to address this gap. This prospective observational study investigated the antibody titers for SARS-CoV-2 spike protein receptor-binding domain (S-IgG) and nucleocapsid protein (N-IgG)
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Local radiotherapy for chemotherapy-refractory Kaposi's sarcoma in an HIV-infected patient: A case report and literature review J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-20 Yutaro Yoshitomi, Akira Kawashima, Hidetsugu Nakayama, Takato Nakamoto, Naokatsu Ando, Haruka Uemura, Daisuke Mizushima, Takahiro Aoki, Junko Tanuma, Katsuji Teruya, Hiroyuki Gatanaga, Koji Watanabe
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Clinical features of pasteurellosis without an animal bite or scratch in comparison with bite/scratch pasteurellosis J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-17 Tsubasa Asaeda, Takashi Ueda, Yasuhiro Nozaki, Yasushi Murakami, Mika Morosawa, Hiroko Inaba, Hitoshi Ogashiwa, Miki Doi, Kazuhiko Nakajima, Manabu Shirakawa, Akifumi Nakamura, Naoto Ikeda, Yuya Sugiyama, Yoshihiro Wada, Takahiro Ito, Yoshio Takesue
Pasteurellosis is a common zoonotic infection that occurs after an animal bite or scratch (B/S). We compared the clinical features of six patients with non-B/S pasteurellosis with those of 14 patients with B/S infections. was identified with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in all six non-B/S infections, whereas 13 of the 14 B/S infections were identified
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Monotherapy vs combination therapy in patients with Klebsiella pneumoniae bloodstream infection: A systematic review and meta-analysis J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-17 Dan Li, Huayun Rao, Yi Xu, Min Zhang, Jie Zhang, Jianrong Luo
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Micafungin-breakthrough Coniochaeta hoffmannii (Lecythophora hoffmannii) fungemia following cord blood transplant in a patient with acute myeloid leukemia successfully treated with voriconazole J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-17 Koh Shinohara, Satoru Itoi, Shigeki Nakamura, Yoshitsugu Miyazaki, Yoshikazu Mutoh, Shotaro Hagiwara, Norio Ohmagari
Phaeohyphomycosis is caused by dematiaceous (pigmented) fungi. Most phaeohyphomycosis is non-invasive infections, however, they can lead to invasive infections, including fungemia and disseminated disease, particularly in severely immunocompromised patients. Invasive phaeohyphomycosis has recently emerged, however, the treatment strategy was not determined because of the intrinsic resistance to antifungals
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Bloodstream infection caused by Wickerhamiella pararugosa in a patient with intestinal obstruction: A case report J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-16 Satoshi Murata, Kazuyuki Mimura, Takayuki Kawamura, Hiroyuki Saito, Hideaki Ohno, Emi Tsujii, Takayuki Shinohara, Yoshitsugu Miyazaki, Takao Ohki
The fungus () has been detected in various human organs but has rarely caused bloodstream infections. This report presents a case of central venous catheter-related bloodstream infection (CRBSI) of in an adult. A female patient in her 80s was admitted to our facility for intestinal obstruction caused by colorectal cancer. The patient's ability to consume food was hindered, necessitating the insertion
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First report of a blaNDM-5-carrying Escherichia coli sequence type 12 isolated from a dog with pyometra in Japan J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-16 Kazuki Harada, Tadashi Miyamoto, Michiyo Sugiyama, Tetsuo Asai
Carbapenemase-producing Enterobacterales (CPE) are a serious concern in human clinical settings. Companion animal–origin CPE have been only rarely identified in several countries, but they have not yet been identified in Japan. In this study, we present the first case of a canine infected with CPE in Japan. The patient was hospitalized due to pyometra. The pus discharged from the patient's uterus was
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Intrinsic clarithromycin heteroresistance in Mycobacterium avium J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-16 Ai Ito, Yuta Nanjo, Chiaki Kajiwara, Ayako Shiozawa, Naohisa Urabe, Sakae Homma, Kazuma Kishi, Kageto Yamada, Yoshikazu Ishii, Kazuhiro Tateda
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Ensitrelvir in patients with SARS-CoV-2: A retrospective chart review J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-15 Masaya Yamato, Masahiro Kinoshita, Shogo Miyazawa, Masayuki Seki, Tomoki Mizuno, Takuhiro Sonoyama
Antivirals with proven effectiveness against the Omicron SARS-CoV-2 variant are required for COVID-19 treatment in hospitalized patients, particularly those with severe underlying conditions. Ensitrelvir, a 3C-like protease inhibitor, received emergency approval in Japan in November 2022, based on evidence of rapid symptom resolution in non-hospitalized patients, but confirmation of its effectiveness
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Factors associated with patient satisfaction with antiretroviral therapy in Japan: A cross-sectional, multicenter study J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-15 Shinichi Hikasa, Masashi Ishihara, Mariko Tsukiji, Yusuke Kunimoto, Kazuko Nobori, Takeshi Kimura, Kenta Onishi, Yuuki Yamamoto, Kyohei Haruta, Yohei Kasiwabara, Kenji Fujii, Takeshi Kimura
Current antiretroviral therapy (ART) regimens are highly effective; therefore, to differentiate between various regimens, considering patient-reported outcomes is essential. This study aimed to assess patient satisfaction with their current ART regimens and investigate factors associated with the Human Immunodeficiency Virus Treatment Satisfaction Questionnaire: Status (HIVTSQs) score. This cross-sectional
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Effect of rifampicin administration on CYP induction in a dermatomyositis patient with vasospastic angina attributable to nilmatrelvir/ritonavir-induced blood tacrolimus elevation: A case report J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-13 Hayato Akamatsu, Yusuke Kohno, Junya Hashizume, Hiroo Nakagawa, Yukinobu Kodama, Hiroaki Kawano, Koji Maemura, Kaname Ohyama
Ritonavir (RTV), which is used in combination with nilmatrelvir (NMV) to treat coronavirus disease 2019 (COVID-19), inhibits cytochrome P450 (CYP) 3A, thereby increasing blood tacrolimus (TAC) levels through a drug–drug interaction (DDI). We experienced a case in which a DDI between the two drugs led to markedly increased blood TAC levels, resulting in vasospastic angina (VSA) and acute kidney injury
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Comparison of the safety and cost-effectiveness of nebulized liposomal amphotericin B and amphotericin B deoxycholate for antifungal prophylaxis after lung transplantation J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-12 Keisuke Umemura, Yoshiki Katada, Shunsaku Nakagawa, Daiki Hira, Yojiro Yutaka, Satona Tanaka, Akihiro Ohsumi, Daisuke Nakajima, Hiroshi Date, Miki Nagao, Tomohiro Terada
Fungal infection after lung transplantation can lead to poor clinical outcome, for which lung transplant recipients require prophylaxis. One of the antifungal agents used after lung transplantation is nebulized amphotericin B (AMB). Nebulized AMB causes adverse events such as dyspnea and airway irritation, and long-term use leads to high economic costs. So far, prophylactic regimens employing AMB deoxycholate
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Prevalence and trends in persistent symptoms following COVID-19 in Japan: A nationwide cross-sectional survey J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-11 Akane Takamatsu, Hitoshi Honda, Toshiki Miwa, Takahiro Tabuchi, Kiyosu Taniguchi, Kenji Shibuya, Yasuharu Tokuda
Even during the endemic phase of the COVID-19 pandemic, the impact of persistent symptoms on patients and healthcare systems remains significant. Thus, a more comprehensive understanding of these symptoms is essential. Using data from the Japan Society and New Tobacco Internet Survey conducted in February 2023, this cross-sectional study investigated the prevalence of, and changes in, persistent COVID-19
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Epidemiology of post-COVID conditions beyond 3 years and factors associated with their persistence longer than 2 years: A cross-sectional study J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-11 Shinichiro Morioka, Mio Nikaido, Shinya Tsuzuki, Satoshi Kutsuna, Sho Saito, Kayoko Hayakawa, Masaya Sugiyama, Norio Ohmagari
This study aimed to investigate the epidemiology of post-coronavirus disease 2019 (COVID-19) conditions (PCCs) beyond 3 years and identify factors associated with their persistence longer than 2 years. Cross-sectional questionnaire-based survey. We surveyed patients who had recovered from COVID-19 and visited our institution from February 2020 to November 2021. Demographic and clinical data and information
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Detailed tracking of antigen and antibody levels during coronavirus disease 2019 treatment in an immunosuppressed patient with anti-neutrophil cytoplasmic autoantibody-associated vasculitis J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-10 Toshitaka Yukishima, Kazuki Furuhashi, Kumiko Shimoyama, Takeru Taki, Chika Azuma, Kenji Yamazaki, Shogo Furukawa, Soma Fukami, Osanori Nagura, Kazuto Katahashi, Keita Yamashita, Masato Maekawa, Noriyoshi Ogawa
A 67-year-old woman with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis was not vaccinated against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and was on multiple immunosuppressive drugs. She was hospitalized because of interstitial shadowing in the lungs and diagnosed with persistent coronavirus disease 2019 (COVID-19). Despite treatment with a recombinant monoclonal
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Bacteremia due to Lachnoanaerobaculum umeaense in a patient with acute myeloid leukemia during chemotherapy: A case report, and a review of the literature J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-08 Julie Bodin, Maria-Pilar Gallego-Hernanz, Chloé Plouzeau Jayle, Anthony Michaud, Lauranne Broutin, Julie Cremniter, Christophe Burucoa, Maxime Pichon
The present case reports a bacteremia due to (a Gram-positive, filamentous, rod-shaped, anaerobic, spore-forming bacillus present in the human oral microbiota) in a patient treated for acute myeloid leukemia. After failed identification by MALDI-TOF, identification was done by sequencing of 16s rRNA. The patient was successfully treated with Amoxicillin-clavulanic acid and ciprofloxacin for seven days
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Seronegative HIV-1 infection in a Japanese man presenting with Pneumocystis pneumonia: Analysis of long-term antibody response and literature review J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-06 Nayuta Seto, Takahiko Fukuchi, Mamiyo Kawakami, Mami Nagashima, Kenji Sadamasu, Shuji Hatakeyama
Seronegative human immunodeficiency virus (HIV) infection, where an HIV-specific antibody response is lacking even in chronic or late-stage HIV infections, is extremely rare. Here, we report the case of a 50-year-old Japanese man presenting with pneumonia who did not produce antibodies against HIV-1 until the initiation of antiretroviral therapy (ART). Fourth-generation antigen–antibody testing temporarily
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Cost-effectiveness of nirmatrelvir/ritonavir for high-risk adult outpatients with COVID-19 in Japan J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-06 Takahito Mizuno, Yu Kondo, Mikiyasu Sakai, Kenichi Saneyasu, Ryota Kojima, Yoshio Miyake
This study aimed to evaluate the cost-effectiveness of nirmatrelvir/ritonavir (Nir/Rit) for adult outpatients with COVID-19 from the perspective of a Japanese public healthcare payer. A cost-effectiveness simulation was conducted comparing Nir/Rit for the outpatient treatment of high-risk COVID-19 patients to best supportive care (BSC) without antiviral or antibody drugs. The analytical model was divided
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External quality assessment survey for SARS-CoV-2 nucleic acid amplification tests in clinical laboratories in Tokyo, 2021 J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-05 Yoshiyuki Sugishita, Rie Moriuchi, Yoshikazu Ishii
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Minimal impact of low-density lipoprotein apheresis on vancomycin serum concentration: A case report J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-04 Yoko Hiyama, Takashi Tomita, Hiroaki Matsuo
Low-density lipoprotein apheresis (LDL-A) is a blood purification therapy used to treat refractory ulcers in patients with arteriosclerosis obliterans. We describe a case of vancomycin treatment in a patient undergoing maintenance hemodialysis and LDL-A therapy and assess its impact on serum vancomycin concentration. The patient underwent LDL-A twice a week (Mondays and Fridays) and maintenance dialysis
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Analysis of bacteremia at first-line antibiotic treatment for febrile neutropenia in children and adolescents: A retrospective, single-center analysis J. Infect. Chemother. (IF 2.2) Pub Date : 2024-01-30 Ryoji Kobayashi, Hirozumi Sano, Satoru Matsushima, Daiki Hori, Masato Yanagi, Daisuke Suzuki
Background Control of bacterial and fungal infections is critical to improving outcomes in hematological neoplastic diseases of children and adolescents. In this study, a retrospective analysis of our previous studies on febrile neutropenia was performed to investigate bacteremia. Procedure From August 2008 to December 2023, five antibiotic studies were performed for febrile and neutropenic pediatric
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The fatal case of “Pigmentibacter” bacteremia following aspiration pneumonia in elderly patient J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-02 Shigeru Azuma, Hitoshi Kawasuji, Ryosuke Nakai, Hiroshi Yamada, Yoshihiro Yoshida, Hiroyuki Kawahara, Mai Suzuki, Shunsuke Mori, Masayoshi Hirata, Kazushige Sugie, Hideki Niimi, Yoshitomo Morinaga, Yoshihiro Yamamoto
“” was first reported in 2021, a novel bacterium of the family , isolated from human blood of the patient with aspiration pneumonia after the drowning accident in Republic of China. However, until now, there is only one report describing “” infection, and no case of isolation from natural environment has been reported so far. Thus, the infectivity and pathogenicity of “” spp. has not been clearly understood
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Age dependent discrepancy between SARS-CoV-2 anti-nucleoprotein antibody and anti-RBD spike protein antibody in children reflects vaccine coverage J. Infect. Chemother. (IF 2.2) Pub Date : 2024-02-02 Yasuhito Fujii, Hidetoshi Ishigaki, Isao Miyairi, Noriyasu Niizeki, Osanori Nagura, Keita Yamashita, Masato Maekawa, Kazuki Furuhashi
COVID-19 has become widespread in Japanese children. However, the impact of varying immunization coverage on the seroprevalence of SARS-CoV-2 in children is unknown. We examined the SARS-CoV-2 antibody in children aged 0 to 18 who were hospitalized at a university hospital from June 2020 through May 2023. The SARS-CoV-2 anti-nucleoprotein (N) antibody and anti-RBD spike (S) protein antibody was measured
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Surgical antimicrobial prophylaxis in Japanese hospitals: Real status and challenges J. Infect. Chemother. (IF 2.2) Pub Date : 2024-01-23 Hiroshi Morioka, Yusuke Koizumi, Toshitaka Watariguchi, Keisuke Oka, Yuka Tomita, Yumi Kojima, Masami Okudaira, Yuji Ito, Junichi Shimizu, Koichi Watamoto, Hiroki Kato, Masatoshi Nagaoka, Manabu Yokota, Chihiro Hasegawa, Takeshi Tsuji, Shinsuke Shimizu, Kenta Ito, Shohei Kawasaki, Kenji Akita, Yuichi Kitagawa, Tetsuya Yagi
Background Information regarding the status of surgical antimicrobial prophylaxis (SAP) in Japanese hospitals is lacking. This study aimed to explore the status of SAP prescriptions for surgeries and adherence to Japanese SAP guidelines. Methods From February to July 2020, a 1-day multicentre point prevalent survey was conducted at 27 hospitals in Aichi Prefecture, Japan. Patients prescribed SAP were
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Characteristics of pediatric patients claimed with acute upper respiratory infection during otorhinolaryngology consultations: A descriptive study of a large Japanese medical claims database J. Infect. Chemother. (IF 2.2) Pub Date : 2024-01-23 Saki Ito, Yuichi Muraki, Ryo Inose, Kanako Mizuno, Ryota Goto, Makiko Kiyosuke, Yoshitsugu Iinuma, Tetsuya Yagi, Hiroki Ohge
This study aimed to clarify other diseases claimed simultaneously with acute upper respiratory infection (URI), antibiotic prescriptions, and examinations associated with infectious diseases in pediatric patients with acute URI insurance claims at otorhinolaryngology outpatient visits. Pediatric patients who visited an otolaryngology department between 2019 and 2021 and were definitively diagnosed
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Successful management of surgical site infection caused by Mycobacterium mageritense in a breast cancer patient J. Infect. Chemother. (IF 2.2) Pub Date : 2024-01-23 Nana Akazawa, Naoya Itoh, Yuichi Ishibana, Hiromi Murakami, Seiko Okumura
Mycobacterium mageritense (M. mageritense), a nontuberculous mycobacterium, is classified as a rapidly growing mycobacterium, class IV in the Runyon Classification. This bacterium is found in soil, water, and other habitats. Infections caused by M. mageritense are relatively rare and no treatment protocol has been established. Herein, we report a case of skin and soft tissue infection caused by M.
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Colistin versus polymyxin B for the treatment of carbapenem-resistant Klebsiella pneumoniae bloodstream infections J. Infect. Chemother. (IF 2.2) Pub Date : 2024-01-18 Tarsila Vieceli, Lilian Rodrigues Henrique, Tatiana Helena Rech, Alexandre Prehn Zavascki
Background To assess the effectiveness of colistin (administered as colistimethate sodium-CMS) and polymyxin B (PMB) for the treatment of bloodstream infections (BSIs) caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). Materials and methods This retrospective cohort included hospitalized adult patients with CRKP BSIs from a single tertiary-care hospital. A univariate analysis comparing CMS
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Relapse of toxocariasis after completion of four-week treatment with albendazole J. Infect. Chemother. (IF 2.2) Pub Date : 2024-01-17 Nobumasa Okumura, Kei Yamamoto, Norio Ohmagari
Food-borne toxocariasis caused by the consumption of raw meat or liver has occasionally been reported from East Asia. We treated a 38-year-old Japanese man who was infected with Toxocara in China and underwent a four-week treatment with albendazole. The liver and lung lesions disappeared after the treatment, suggesting that the treatment was successful. One month after the end of the treatment, the
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Trend in antibiotic prescription at pediatric primary emergency medical centers in Japan: A multi-center, cross-sectional study J. Infect. Chemother. (IF 2.2) Pub Date : 2024-01-17 Shogo Otake, Takayo Shoji, Kenta Yamada, Makoto Kimura, Shota Myojin, Naohiro Kamiyoshi, Fumihiro Ochi, Mari Nezu, Akihito Ishida, Isao Miyairi, Masashi Kasai
Introduction Antimicrobial resistance is a global issue, and implementation of antimicrobial stewardship programs in outpatient settings is crucial. Japan has also focused on outpatient oral antimicrobial stewardship programs and difficulties in standardizing prescriptions have led to overprescription in primary emergency medical centers. There is a lack of research investigating the antibiotic prescription
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Third nationwide surveillance of bacterial pathogens in patients with acute uncomplicated cystitis conducted by the Japanese surveillance committee during 2020 and 2021: Antimicrobial susceptibility of Escherichia coli, Klebsiella pneumoniae, and Staphylococcus saprophyticus J. Infect. Chemother. (IF 2.2) Pub Date : 2024-01-17 Koichiro Wada, Ichiro Tsuboi, Satoshi Takahashi, Mitsuru Yasuda, Jun Miyazaki, Kanao Kobayashi, Masahiro Matsumoto, Hiroshi Hayami, Shingo Yamamoto, Hiroshi Kiyota, Junko Sato, Tetsuya Matsumoto, Naoki Hasegawa, Intetsu Kobayashi, Naoya Masumori, Takahiro Kimura, Hiroki Yamada, Kazumasa Matsumoto, Kiyohito Ishikawa, Kiyohide Fujimoto, Michikazu Terado
The Japanese surveillance committee conducted a third nationwide surveillance of antimicrobial susceptibility of acute uncomplicated cystitis at 55 facilities throughout Japan between April 2020 and September 2021. In this surveillance, we investigated the susceptibility of Escherichia coli (E. coli), Klebsiella pneumoniae (K. pneumoniae), and Staphylococcus saprophyticus (S. saprophyticus) for various
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Successful management of persistent COVID-19 using combination antiviral therapy (nirmatrelvir/ritonavir and remdesivir) and intravenous immunoglobulin transfusion in an immunocompromised host who had received CD20 depleting therapy for follicular lymphoma J. Infect. Chemother. (IF 2.2) Pub Date : 2024-01-17 Taketomo Maruki, Hidetoshi Nomoto, Noriko Iwamoto, Kei Yamamoto, Masami Kurokawa, Kiyoko Iwatsuki-Horimoto, Seiya Yamayoshi, Yutaka Suzuki, Yoshihiro Kawaoka, Norio Ohmagari
The management of persistent symptomatic coronavirus disease 2019 (COVID-19) infections in immunocompromised patients remains unclear. Here, we present the first case of successful antiviral therapy (nirmatrelvir/ritonavir and remdesivir) in combination with intravenous immunoglobulin (IVIg) in a patient who had received CD20 depleting therapy for follicular lymphoma and experienced recurrent COVID-19
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Epidemiologic evaluation of pulmonary paragonimiasis in Japan using a Japanese nationwide administrative database J. Infect. Chemother. (IF 2.2) Pub Date : 2024-01-12 Issei Ikushima, Kei Yamasaki, Masahiro Tahara, Kazuki Nemoto, Kentaro Akata, Hiroaki Ikegami, Chinatsu Nishida, Keiji Muramatsu, Yoshihisa Fujino, Shinya Matsuda, Kiyohide Fushimi, Hiroshi Mukae, Kazuhiro Yatera
Background Paragonimiasis is a parasitic disease primarily contracted through consumption of undercooked freshwater crustaceans or wild boar meat. Large-scale nationwide epidemiological data on paragonimiasis are lacking. In this study, we aimed to investigate the nationwide epidemiology of hospitalized patients with paragonimiasis in Japan using a comprehensive nationwide Japanese administrative database
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Retraction notice to <" Severe disseminated infection by hypermucoviscous Klebsiella pneumoniae successfully treated by intensive therapy with continuous hemodiafiltration using AN69ST: A case report and review of the literature"> <[Journal of Infection and Chemotherapy 29 (2023) 1075–1080]> J. Infect. Chemother. (IF 2.2) Pub Date : 2024-01-12
This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/policies/article-withdrawal). This article has been retracted at the request of the Editors. The article is a duplicate of a paper that has already been published in Urology Case Reports, Vol.46 (2022) 102290. DOI as https://doi.org/10.1016/j.eucr.2022.102290. Redundant publications overweigh
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Ceftazidime-avibactam in the treatment of bacteremia due to carbapenem-resistant gram-negative bacteria in hematological patients: Experience in a single center J. Infect. Chemother. (IF 2.2) Pub Date : 2024-01-11 Sisi Zhen, Qingsong Lin, Zhangjie Chen, Yuyan Shen, Xin Chen, Aiming Pang, Donglin Yang, Rongli Zhang, Qiaoling Ma, Yi He, Jialin Wei, Weihua Zhai, Erlie Jiang, Mingzhe Han, Jianxiang Wang, Sizhou Feng
Introduction Limited experience exists with ceftazidime-avibactam (CAZ-AVI) in treating bacteremia caused by carbapenem-resistant Enterobacterales (CRE) and Pseudomonas aeruginosa (CRPA) in hematological patients. Methods We performed a single-center, retrospective, observational study including patients who received CAZ-AVI for bacteremia due to CRE or CRPA between 2018 and 2022. The primary outcome
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Human mpox presenting with penile edema and ulcer: A case report J. Infect. Chemother. (IF 2.2) Pub Date : 2024-01-11 Yu Miyazaki, Takuya Adachi
Human mpox, which has spread worldwide since May 2022, is characterized by symptoms involving the genital area; however, its treatment methods and clinical course are not completely understood. Furthermore, penile swelling in human mpox can be difficult to differentiate from cellulitis and antibiotic use has been reported in such cases. Herein, we report a case of human mpox in Japan with prominent