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Prominent Expression of COL2A1, ACAN and IHH Genes are Observed in the Differentiation of Human Hematopoietic Stem Cells into Articular Type of Chondrocytes Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-04-18 Echambadi Loganathan Samundeshwari, Surekha kattaru, Sireesha Kodavala, Chodimella Chandrasekhar, Potukuchi Venkata Gurunadha Krishna Sarma
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The Endometrial Stem/Progenitor Cells and Their Niches Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-04-18 Baolan Sun, Xi Cheng, Qiang Wu
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Murine and Human-Purified very Small Embryonic-like Stem Cells (VSELs) Express Purinergic Receptors and Migrate to Extracellular ATP Gradient Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-04-18 Kamila Bujko, Katarzyna Brzezniakiewicz-Janus, Justyna Jarczak, Magdalena Kucia, Mariusz Z. Ratajczak
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Correction: Mesenchymal Stem Cell-Derived Extracellular Vesicle Therapy for Asthma in Murine Models: A Systematic Review and Meta-analysis Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-04-17 Shahryar Rajai Firouzabadi, Ida Mohammadi, Kiana Ghafourian, Arda Kiani, Seyed Mahmoud Hashemi
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Stem Cell Secretions as a Potential Therapeutic Agent for Autism Spectrum Disorder: A Narrative Review Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-04-17 Mariam Darwish, Rojine El Hajj, Luna Khayat, Nada Alaaeddine
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Biomechanical Characterization of Retinal Pigment Epitheliums Derived from hPSCs Using Atomic Force Microscopy Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-04-16 Elise Herardot, Maxime Liboz, Guillaume Lamour, Michel Malo, Alexandra Plancheron, Walter Habeler, Camille Geiger, Elie Frank, Clément Campillo, Christelle Monville, Karim Ben M’Barek
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Current Perspectives and Progress in Preoperative Portal Vein Embolization with Stem Cell Augmentation (PVESA) Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-04-13 Allan John R. Barcena, Tyler C. Owens, Sophie Melancon, Isias Workeneh, Hop S. Tran Cao, Jean-Nicolas Vauthey, Steven Y. Huang
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Characterization of Stem Cell-Derived Langerhans-Like Cells: New Model Immune Cells for Tick-Borne Encephalitis Virus Infection Studies Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-04-11 Hana Mašková, Lenka Doudová, Jaroslava Lieskovská, Libor Grubhoffer, Ján Štěrba
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Gastric Cancer Mesenchymal Stem Cells Trigger Endothelial Cell Functional Changes to Promote Cancer Progression Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-04-10 Linjing Cui, Ting Liu, Chao Huang, Fumeng Yang, Liqi Luo, Li Sun, Yuanyuan Zhao, Deqiang Wang, Mei Wang, Yong Ji, Wei Zhu
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Crispr-Based Editing of Human Pluripotent Stem Cells for Disease Modeling Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-04-02 Yun Chang, Feng Lan, Yongshuai Zhang, Shuhong Ma
The CRISPR system, as an effective genome editing technology, has been extensively utilized for the construction of disease models in human pluripotent stem cells. Establishment of a gene mutant or knockout stem cell line typically relies on Cas nuclease-generated double-stranded DNA breaks and exogenous templates, which can produce uncontrollable editing byproducts and toxicity. The recently developed
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Advances in Organoid Technology: A Focus on Corneal Limbal Organoids Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-04-01 Chuwei Lu, Qihua Le
Organoid technology provides a versatile platform for simulating organogenesis, investigating disease pathogenesis, and exploring therapeutic interventions. Among various types of organoids that have been developed, corneal limbal organoids, the three-dimensional miniaturized corneas which are derived from either pluripotent stem cells or limbal epithelial stem cells, are particularly promising for
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Advances and Applications of Cancer Organoids in Drug Screening and Personalized Medicine Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-03-27 Yujia Yang, Yajie Kong, Jinlei Cui, Yu Hou, Zhanjing Gu, Cuiqing Ma
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Single-cell Profiling of Reprogrammed Human Neural Stem Cells Unveils High Similarity to Neural Progenitors in the Developing Central Nervous System Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-03-22
Abstract Background Similar to induced pluripotent cells (iPSCs), induced neural stem cells (iNSCs) can be directly converted from human somatic cells such as dermal fibroblasts and peripheral blood monocytes. While previous studies have demonstrated the resemblance of iNSCs to neural stem cells derived from primary sources and embryonic stem cells, respectively, a comprehensive analysis of the correlation
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Interleukin-19 in Bone Marrow Contributes to Bone Loss Via Suppressing Osteogenic Differentiation Potential of BMSCs in Old Mice Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-03-19 Enjun He, Haitao Sui, Hongjie Wang, Xiang Zhao, Weihong Guo, Zhicheng Dai, Zhenkai Wu, Kai Huang, Qinghua Zhao
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From Pluripotent Stem Cells to Organoids and Bioprinting: Recent Advances in Dental Epithelium and Ameloblast Models to Study Tooth Biology and Regeneration Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-03-18 Florian Hermans, Steffie Hasevoets, Hugo Vankelecom, Annelies Bronckaers, Ivo Lambrichts
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Development of an Inflamed High Throughput Stem-cell-based Gut Epithelium Model to Assess the Impact of Annexin A1 Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-03-18 Milena Fronza Broering, Stefania Tocci, Noah T. Sout, Chris Reutelingsperger, Sandra H.P. Farsky, Soumita Das, Ibrahim M. Sayed
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Understanding the Angiogenic Characteristics of Clinical-Grade Mesenchymal Stromal Cells Isolated from Human Umbilical Cord Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-03-16
Abstract Addressing the challenges in managing ischemic tissue repair and remodelling remains a prominent clinical concern. Current research is heavily concentrated on identifying innovative cell-based therapies with the potential to enhance revascularization in patients affected by these diseases. We have previously developed and validated a manufacturing process for human umbilical cord mesenchymal
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Mesenchymal Stem Cell-Derived Extracellular Vesicle Therapy for Asthma in Murine Models: A Systematic Review and Meta-analysis Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-03-16 Shahryar Rajai Firouzabadi, Ida Mohammadi, Kiana Ghafourian, Arda Kiani, Seyed Mahmoud Hashemi
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Bone Marrow Nucleated Cells and Bone Marrow-Derived CD271+ Mesenchymal Stem Cell in Treatment of Encephalopathy and Drug-Resistant Epilepsy Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-03-14 Olga Milczarek, Danuta Jarocha, Anna Starowicz–Filip, Maciej Kasprzycki, Jacek Kijowski, Anna Mordel, Stanisław Kwiatkowski, Marcin Majka
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Trained innate immunity modulates osteoblast and osteoclast differentiation Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-03-13 N. R. Rahmani, R. Belluomo, M. C. Kruyt, D. Gawlitta, L. A. B. Joosten, H. Weinans, M. Croes
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Osteopontin Rejuvenates Senescent Adipose-Derived Stem Cells and Restores their Bone Tissue Regenerative Function Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-03-12 Yiran Zhang, Junni Zhang, Pooria Lesani, Zufu Lu, Hala Zreiqat
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Initiation of Cancer: The Journey From Mutations in Somatic Cells to Epigenetic Changes in Tissue-resident VSELs Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-03-08 Deepa Bhartiya, Sherif Raouf, Kshama Pansare, Anish Tripathi, Ashish Tripathi
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A Senescence-Associated Secretory Phenotype of Bone Marrow Mesenchymal Stem Cells Inhibits the Viability of Breast Cancer Cells Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-03-08 Meng Li, Jie-Xi Liu, Bo Ma, Jin-Yu Liu, Ji Chen, Fang Jin, Cheng-Hu Hu, Hao-Kun Xu, Chen-Xi Zheng, Rui Hou
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Deciphering the Epigenetic Landscape: Placental Development and Its Role in Pregnancy Outcomes Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-03-08 Yujia Chen, Zhoujie Ye, Meijia Lin, Liping Zhu, Liangpu Xu, Xinrui Wang
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Complementary and Inducible creERT2 Mouse Models for Functional Evaluation of Endothelial Cell Subtypes in the Bone Marrow Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-03-04
Abstract In the adult bone marrow (BM), endothelial cells (ECs) are an integral component of the hematopoietic stem cell (HSC)-supportive niche, which modulates HSC activity by producing secreted and membrane-bound paracrine signals. Within the BM, distinct vascular arteriole, transitional, and sinusoidal EC subtypes display unique paracrine expression profiles and create anatomically-discrete microenvironments
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Advances in Treatments for Epidermolysis Bullosa (EB): Emphasis on Stem Cell-Based Therapy Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-03-02 Ramin Raoufinia, Hamid reza Rahimi, Neda Keyhanvar, Meysam Moghbeli, Nima Abdyazdani, Mehdi Rostami, Karim Naghipoor, Fatemeh Forouzanfar, Sara Foroudi, Ehsan Saburi
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Mesenchymal Stromal/Stem Cell Therapy Improves Salivary Flow Rate in Radiation-Induced Salivary Gland Hypofunction in Preclinical in vivo Models: A Systematic Review and Meta-Analysis Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-03-02 Amanda-Louise Fenger Carlander, Anders Kierkegaard Gundestrup, Per Marcus Jansson, Bjarke Follin, Cecilie Hoeeg, Birgitte Saima Kousholt, Rasmus Tolstrup Larsen, Kathrine Kronberg Jakobsen, Susie Rimborg, Anne Fischer-Nielsen, Christian Grønhøj, Christian von Buchwald, Charlotte Duch Lynggaard
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Alternatives of Animal Models for Biomedical Research: a Comprehensive Review of Modern Approaches Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-03-01 Abhinav Vashishat, Preeti Patel, Ghanshyam Das Gupta, Balak Das Kurmi
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Mesenchymal Stem Cells on Mortality in COVID-19 Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-03-01 Jinlv Qin, Guizuo Wang, Dong Han
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Enhancing Vasculogenesis in Dental Pulp Development: DPSCs-ECs Communication via FN1-ITGA5 Signaling Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-02-28 Tiankai Di, Chao Feng, Lulu Wang, Jinlong Xu, Yang Du, Baixiang Cheng, Yujiang Chen, Lian Wu
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Bone Regeneration with Mesenchymal Stem Cells in Scaffolds: Systematic Review of Human Clinical Trials Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-02-26 Astero Maria Theodosaki, Maria Tzemi, Nikiforos Galanis, Athina Bakopoulou, Eleni Kotsiomiti, Eleni Aggelidou, Aristeidis Kritis
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Equine Embryonic Stem Cell-Derived Tenocytes are Insensitive to a Combination of Inflammatory Cytokines and Have Distinct Molecular Responses Compared to Primary Tenocytes Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-02-24
Abstract Tissue fibrosis following tendon injury is a major clinical problem due to the increased risk of re-injury and limited treatment options; however, its mechanism remains unclear. Evidence suggests that insufficient resolution of inflammation contributes to fibrotic healing by disrupting tenocyte activity, with the NF-κB pathway being identified as a potential mediator. Equine embryonic stem
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Stem Cell Extracellular Vesicles as Anti-SARS-CoV-2 Immunomodulatory Therapeutics: A Systematic Review of Clinical and Preclinical Studies Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-02-23 Sarah Hamdy Ahmed, Mohamed Atef AlMoslemany, Kenneth Whitaker Witwer, Ahmed Gamal Tehamy, Nagwa El-Badri
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Exosomes Derived from Adipose Stem Cells Enhance Angiogenesis in Diabetic Wound Via miR-146a-5p/JAZF1 Axis Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-02-23 Dehui Che, Xinjian Xiang, Juan Xie, Zenghong Chen, Qiong Bao, Dongsheng Cao
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Evaluation of the Efficacy of Stem Cells Therapy in the Periodontal Regeneration: A Meta-Analysis and Mendelian Randomization Study Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-02-22 Jing Hu, Ze-Yue Ou-Yang, Ya-Qiong Zhao, Jie Zhao, Li Tan, Qiong Liu, Min-yuan Wang, Qin Ye, Yao Feng, Meng-Mei Zhong, Ning-Xin Chen, Xiao-Lin Su, Qian Zhang, Yun-Zhi Feng, Yue Guo
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Phenotypic Transitions the Processes Involved in Regulation of Growth and Proangiogenic Properties of Stem Cells, Cancer Stem Cells and Circulating Tumor Cells Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-02-19 Magdalena Kulus, Maryam Farzaneh, Artur Bryja, Mojtaba Zehtabi, Shirin Azizidoost, Mahrokh Abouali Gale Dari, Afsaneh Golcar-Narenji, Hanna Ziemak, Mikołaj Chwarzyński, Hanna Piotrowska–Kempisty, Piotr Dzięgiel, Maciej Zabel, Paul Mozdziak, Dorota Bukowska, Bartosz Kempisty, Paweł Antosik
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Hematopoiesis Revolves Around the Primordial Evolutional Rhythm of Purinergic Signaling and Innate Immunity – A Journey to the Developmental Roots Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-02-16 Mariusz Z. Ratajczak, Kamila Bujko, Katarzyna Brzezniakiewicz-Janus, Janina Ratajczak, Magdalena Kucia
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Rapamycin Inhibits Senescence and Improves Immunomodulatory Function of Mesenchymal Stem Cells Through IL-8 and TGF-β Signaling Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-02-10 Aaron J Sheppard, Kristin Delgado, Ann Marie Barfield, Qinqin Xu, Patrick A Massey, Yufeng Dong, Richard S Barton
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Fine Tuning Mesenchymal Stromal Cells – Code For Mitigating Kidney Diseases Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-02-09 Diksha Makkar, Diksha Gakhar, Vinod Mishra, Aruna Rakha
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New Perspectives in Stem Cell Transplantation and Associated Therapies to Treat Retinal Diseases: From Gene Editing to 3D Bioprinting Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-02-06 Gabrieli Bovi dos Santos, Théo Henrique de Lima-Vasconcellos, Marília Inês Móvio, Alexander Birbrair, Carolina Beltrame Del Debbio, Alexandre Hiroaki Kihara
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Effect of Octamer-Binding Transcription Factor 4 Overexpression on the Neural Induction of Human Dental Pulp Stem Cells Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-02-05 Maria R. Gancheva, Karlea Kremer, James Breen, Agnes Arthur, Anne Hamilton-Bruce, Paul Thomas, Stan Gronthos, Simon Koblar
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Mesenchymal Stem Cell-based Scaffolds in Regenerative Medicine of Dental Diseases Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-02-03
Abstract Biomedical engineering breakthroughs and increased patient expectations and requests for more comprehensive care are propelling the field of regenerative dentistry forward at a fast pace. Stem cells (SCs), bioactive compounds, and scaffolds are the mainstays of tissue engineering, the backbone of regenerative dentistry. Repairing damaged teeth and gums is a significant scientific problem at
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The Regenerative Microenvironment of the Tissue Engineering for Urethral Strictures Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-02-02
Abstract Urethral stricture caused by various reasons has threatened the quality of life of patients for decades. Traditional reconstruction methods, especially for long-segment injuries, have shown poor outcomes in treating urethral strictures. Tissue engineering for urethral regeneration is an emerging concept in which special designed scaffolds and seed cells are used to promote local urethral regeneration
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Extracellular Vesicles Derived from Glioma Stem Cells Affect Glycometabolic Reprogramming of Glioma Cells Through the miR-10b-5p/PTEN/PI3K/Akt Pathway Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-01-31 Shun Li, Lifang Mao, Lvmeng Song, Xiaochao Xia, Zihao Wang, Yinchuan Cheng, Jinqing Lai, Xiaoping Tang, Xiangrong Chen
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Circular RNA-Mediated Regulation of Oral Tissue-Derived Stem Cell Differentiation: Implications for Oral Medicine and Orthodontic Applications Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-01-27 Tudor-Sergiu Suciu, Dana Feștilă, Ioana Berindan-Neagoe, Andreea Nutu, Gabriel Armencea, Alexandra Iulia Aghiorghiesei, Talida Vulcan, Mihaela Băciuț
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Stem Cell-Based Regenerative Approaches for the Treatment of Cleft Lip and Palate: A Comprehensive Review Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-01-25 Helia Sharif, Heliya Ziaei, Nima Rezaei
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Mitochondria in Mesenchymal Stem Cells: Key to Fate Determination and Therapeutic Potential Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-01-24 Yang Liu, Lingjuan Wang, Jihui Ai, Kezhen Li
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A Simple Efficient Inexpensive Device for Separation of Trypsinized Cells from Tissue Fragments Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-01-23 Seyed Mohammad-Hossein Shetab-Boushehri, Seyed Vahid Shetab-Boushehri
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Exploring the Protective Effect of Total Flavonoids from Semen Cuscutae on Ovarian Germline Stem Cells Based on Notch Signaling Pathway Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-01-15 Yuan Li, Hanqian Du, Jiashan Li, Zehui Li, Li Guo, Panyu Xu, Ying Xu, Na Lin
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Non-haematopoietic Sca-1+ Cells in the Retina of Adult Mice Express Functional TLR2 Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-01-06
Abstract The mammal retina does not have the capacity to regenerate throughout life, although some stem and progenitor cells persist in the adult retina and might retain multipotentiality, as previously described in many tissues. In this work we demonstrate the presence of a small lineage− Sca-1+ cell population in the adult mouse retina which expresses functional TLR2 receptors as in vitro challenge
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Stem Cell-Based Strategies: The Future Direction of Bioartificial Liver Development Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2024-01-03 Lei Feng, Yi Wang, Yu Fu, Ting Li, Guolin He
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Chimeric Antigen Receptor (CAR)-Based Cell Therapy for Type 1 Diabetes Mellitus (T1DM); Current Progress and Future Approaches Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2023-12-28 Vahid Mohammadi, Armin Jahani Maleki, Mahdis Nazari, Amir Siahmansouri, Amirhosein Moradi, Reza Elahi, Abdolreza Esmaeilzadeh
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The Chaperone Protein Cct5 is Essential for Hematopoietic Stem Cell Maintenance Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2023-12-28 Linxi Li, Jie Huang, Suping Zhang, Chunxu Yao, Yandan Chen, Haitao Wang, Bin Guo
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Could Transplantation into the Thyroid Gland Benefit Pancreatic Islet Grafting in Unstable Type 1 Diabetes (T1DM), Complicated Type 2 Diabetes (T2DM), and Patients with Total Pancreatectomy? Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2023-12-28
Abstract Background Insular allograft for unstable type 1 diabetes and autograft in pancreatectomy patients are nowadays considered established procedures with precise indications and predictable outcomes. The clinical outcome of islet transplantation is similar to that of pancreas transplantation, avoiding the complications associated with organ transplantation. Objective We hypothesised that transplantation
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miR-155-5p/Bmal1 Modulates the Senescence and Osteogenic Differentiation of Mouse BMSCs through the Hippo Signaling Pathway Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2023-12-27 Lanxin Zhang, Chengxiaoxue Zhang, Jiawen Zheng, Yuhong Wang, Xiaoyu Wei, Yuqing Yang, Qing Zhao
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Effect of the IGF-1/PI3K/AKT Pathway on the Proliferation of Mouse bone Marrow Mesenchymal stem Cells under Negative Pressure Modulation Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2023-12-26 Xiya Wu, Zhiyi Lin, Jie Cui, Xiongfeng Yang, Hongwei Zhang, Renyi Jing
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TET1 Regulates Proliferation of Mouse Skin-Derived Stem Cells In Vitro Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2023-12-19 Tian Qiao, Li Li, Ming-Xin Zang, Yi-Nuo Jiang, Sha-Sha Wang, Chun-Xiao Li, Xin-Xiang Xie, Geng Zhang, Ying Zhang, Wei Ge, Wei Shen, Shun-Feng Cheng
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Sorting Technology for Mesenchymal Stem Cells from a Single Tissue Source Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2023-12-19 Xinyi Feng, Fangfang Qi, Hailin Wang, Wenzhen Li, Yuyang Gan, Caiyu Qi, Zhen Lin, Lu Chen, Piao Wang, Zhiqi Hu, Yong Miao
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Insights on Three Dimensional Organoid Studies for Stem Cell Therapy in Regenerative Medicine Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2023-12-14 Precious Earldom Mulaudzi, Heidi Abrahamse, Anine Crous
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Retinal Organoids: A Next-Generation Platform for High-Throughput Drug Discovery Stem Cell Rev and Rep. (IF 4.8) Pub Date : 2023-12-11 Hongkun Zhao, Fei Yan