-
Optical recordings of organellar membrane potentials and the components of membrane conductance in lysosomes J. Phys. (IF 5.5) Pub Date : 2024-04-16 Cristian Castillo-Velasquez, Ella Matamala, Diego Becerra, Patricio Orio, Sebastian E. Brauchi
-
Motor unit discharge rate modulation during isometric contractions to failure is intensity- and modality-dependent J. Phys. (IF 5.5) Pub Date : 2024-04-15 Tamara Valenčič, Paul Ansdell, Callum G. Brownstein, Padraig M. Spillane, Aleš Holobar, Jakob Škarabot
-
On the role of dysferlin in striated muscle: membrane repair, t-tubules and Ca2+ handling J. Phys. (IF 5.5) Pub Date : 2024-04-14 C. J. Quinn, E. J. Cartwright, A. W. Trafford, K. M. Dibb
-
Recombinant human proteoglycan 4 lowers inflammation and atherosclerosis susceptibility in female low-density lipoprotein receptor knockout mice J. Phys. (IF 5.5) Pub Date : 2024-04-12 Menno Hoekstra, Olga S. C. Snip, Philip Janusz, Mireia N. A. Bernabé Kleijn, Edward R. Truitt, Benjamin D. Sullivan, Tannin A. Schmidt, Gregory D. Jay, Miranda Van Eck
-
Commonality and heterogeneity of pacemaker mechanisms in the male reproductive organs J. Phys. (IF 5.5) Pub Date : 2024-04-12 Hikaru Hashitani, Mitsue Takeya, Dirk F. van Helden
-
Coordinating activation of endo-lysosomal two-pore channels and TRP mucolipins J. Phys. (IF 5.5) Pub Date : 2024-04-10 Yu Yuan, Dawid Jaślan, Taufiq Rahman, Franz Bracher, Christian Grimm, Sandip Patel
-
Estimation of persistent sodium-current density in rat hippocampal mossy fibre boutons: Correction of space-clamp errors J. Phys. (IF 5.5) Pub Date : 2024-04-09 Ricardo Murphy, Henrik Alle, Jörg R. P. Geiger, Johan F. Storm
-
Histone-deacetylation inhibitors – old tools in new applications may ameliorate the consequences of social isolation on mental health J. Phys. (IF 5.5) Pub Date : 2024-04-09 Lars Paeger
‘Happiness is only real when shared’ marks the end of the motion picture Into the Wild, named after the corresponding book by Jon Krakauer. Conversely, the lack of social interaction causes adverse effects. This relationship has been subject to a vast number of psychological studies. A new study led by Zhen Yan and colleagues at the State University of New York Buffalo's Jacobs School of Medicine and
-
Changes in intra- and interlimb reflexes from hindlimb cutaneous afferents after staggered thoracic lateral hemisections during locomotion in cats J. Phys. (IF 5.5) Pub Date : 2024-04-09 Stephen Mari, Charly G. Lecomte, Angèle N. Merlet, Johannie Audet, Sirine Yassine, Oussama Eddaoui, Gabriel Genois, Charlène Nadeau, Jonathan Harnie, Ilya A. Rybak, Boris I. Prilutsky, Alain Frigon
-
Channelling calcium signals to therapeutics J. Phys. (IF 5.5) Pub Date : 2024-04-05 Grace E. Stutzmann, Jonathan Soboloff
In 1936, in his Nobel Prize speech, Otto Loewi proclaimed ‘Ja Kalzium, das ist alles’, which translates as ‘yes Ca2+, that's all’, generally interpreted to mean that ‘Ca2+ is everything’. This oft-quoted proclamation initially referred to the critical role Ca2+ plays in neurotransmission, but the quote is often construed within the broader context of its highly pleiotropic nature. Indeed, the list
-
Motor learning changes the axon initial segment of the spinal motoneuron J. Phys. (IF 5.5) Pub Date : 2024-04-03 Yu Wang, Yi Chen, Lu Chen, Bruce J. Herron, Xiang Yang Chen, Jonathan R. Wolpaw
-
Acute effects of MitoQ on vascular endothelial function are influenced by cardiorespiratory fitness and baseline FMD in middle-aged and older adults J. Phys. (IF 5.5) Pub Date : 2024-04-03 Nicholas A. Carlini, Matthew P. Harber, Bradley S. Fleenor
-
Impact of capillary and sarcolemmal proximity on mitochondrial structure and energetic function in skeletal muscle J. Phys. (IF 5.5) Pub Date : 2024-04-02 Hailey A. Parry, T. Bradley Willingham, Kevin A. Giordano, Yuho Kim, Shureed Qazi, Jay R. Knutson, Christian A. Combs, Brian Glancy
-
Intrinsic motoneuron properties in typical human development J. Phys. (IF 5.5) Pub Date : 2024-03-30 Ghazaleh Mohammadalinejad, Babak Afsharipour, Alex Yacyshyn, Jennifer Duchcherer, Jack Bashuk, Erin Bennett, Gregory E. P. Pearcey, Francesco Negro, Katharina A. Quinlan, David J. Bennett, Monica A. Gorassini
-
Regulatory mechanism of FCGR2A in macrophage polarization and its effects on intervertebral disc degeneration J. Phys. (IF 5.5) Pub Date : 2024-03-27 Jiaying Luo, Guoxin Jin, Shaoqian Cui, Huan Wang, Qi Liu
-
Role of arm reaching movement kinematics in friction perception at initial contact with smooth surfaces J. Phys. (IF 5.5) Pub Date : 2024-03-28 Naqash Afzal, Sophie du Bois de Dunilac, Alastair J. Loutit, Helen O. Shea, Pablo Martinez Ulloa, Heba Khamis, Richard M. Vickery, Michaël Wiertlewski, Stephen J. Redmond, Ingvars Birznieks
-
A narrative review of periodic breathing during sleep at high altitude: From acclimatizing lowlanders to adapted highlanders J. Phys. (IF 5.5) Pub Date : 2024-03-27 Alexander Patrician, James D. Anholm, Philip N. Ainslie
-
Mechanisms underpinning sympathoexcitation in hypoxia J. Phys. (IF 5.5) Pub Date : 2024-03-27 Lydia L. Simpson, Mike Stembridge, Christoph Siebenmann, Jonathan P. Moore, Justin S. Lawley
-
Extended period of ventilation before delayed cord clamping augments left-to-right shunting and decreases systemic perfusion at birth in preterm lambs J. Phys. (IF 5.5) Pub Date : 2024-03-26 Joseph J. Smolich, Kelly R. Kenna, Jonathan P. Mynard
-
A short treatment with resveratrol after a renal ischaemia–reperfusion injury prevents maladaptive repair and long-term chronic kidney disease in rats J. Phys. (IF 5.5) Pub Date : 2024-03-26 Miguel Ángel Martínez-Rojas, Hiram Balcázar, María Susana Ponce-Nava, Isaac González-Soria, Brenda Marquina-Castillo, Rosalba Pérez-Villalva, Norma A. Bobadilla
-
Morning exercise and pre-breakfast metformin interact to reduce glycaemia in people with type 2 diabetes: a randomized crossover trial J. Phys. (IF 5.5) Pub Date : 2024-03-24 Brenda J. Peña Carrillo, Emily Cope, Sati Gurel, Andres Traslosheros, Amber Kenny, Oscar Michot-Duval, Nimesh Mody, Mirela Delibegovic, Sam Philip, Frank Thies, Dimitra Blana, Brendan M. Gabriel
-
Pacemaking in the lymphatic system J. Phys. (IF 5.5) Pub Date : 2024-03-23 Michael J. Davis, Scott D. Zawieja
-
Surviving birth at high altitude J. Phys. (IF 5.5) Pub Date : 2024-03-23 Alexandra Heath-Freudenthal, Alejandra Estrada, Inge von Alvensleben, Colleen G. Julian
-
Multispectral brain connectivity during visual attention distinguishes controlled from uncontrolled hypertension J. Phys. (IF 5.5) Pub Date : 2024-03-22 Jake J. Son, Yasra Arif, Davina Oludipe, Lucas Weyrich, Abraham D. Killanin, Alex I. Wiesman, Hannah J. Okelberry, Madelyn P. Willett, Hallie J. Johnson, Tony W. Wilson
-
The neurorehabilitation of post-stroke dysphagia: Physiology and pathophysiology J. Phys. (IF 5.5) Pub Date : 2024-03-22 Ayodele Sasegbon, Ivy Cheng, Shaheen Hamdy
-
Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle J. Phys. (IF 5.5) Pub Date : 2024-03-21 Yuki Tamura, Eunbin Jee, Karina Kouzaki, Takaya Kotani, Koichi Nakazato
-
The vascular geometry of the choriocapillaris is associated with spatially heterogeneous molecular exchange with the outer retina J. Phys. (IF 5.5) Pub Date : 2024-03-21 Caitlin D. Faust, Christian A. Klettner, Marc Toso, Gregory S. Hageman, Ian Eames, Philip J. Luthert, Moussa A. Zouache
-
Motor unit modes in the calf muscles during a submaximal isometric contraction are changed by brief stretches J. Phys. (IF 5.5) Pub Date : 2024-03-21 Logan E. Weinman, Alessandro Del Vecchio, Melissa R. Mazzo, Roger M. Enoka
-
Antagonism of 5-HT2 receptors attenuates self-sustained firing of human motor units J. Phys. (IF 5.5) Pub Date : 2024-03-19 Benjamin I. Goodlich, Gregory E. P. Pearcey, Alessandro Del Vecchio, Sean A. Horan, Justin J. Kavanagh
-
Systemic histone deacetylase inhibition ameliorates the aberrant responses to acute stress in socially isolated male mice J. Phys. (IF 5.5) Pub Date : 2024-03-18 Luis Gustavo Hernandez Carballo, Pei Li, Rachel Senek, Zhen Yan
-
Distinct electrophysiological properties of long-range GABAergic and glutamatergic neurons from the lateral amygdala to the auditory cortex of the mouse J. Phys. (IF 5.5) Pub Date : 2024-03-17 Alice Bertero, Alfonso junior Apicella
-
Renin the show: neuropilin-1's role in regulating juxtaglomerular cells J. Phys. (IF 5.5) Pub Date : 2024-03-17 Kyle H. Moore, Bryan K. Becker
In this issue of The Journal of Physiology, Shen et al. describe how neuropilin-1 mediates juxtaglomerular cell (JGC) fate and renin production (Shen et al., 2024). Renin is an enzyme that catalyses the conversion of angiotensinogen to angiotensin I, a key step in renin–angiotensin–aldosterone system's regulation of kidney sodium reabsorption, glomerular filtration rate (GFR) and blood pressure. Granules
-
Muscle fibre typology affects whole-body metabolic rate during isolated muscle contractions and human locomotion J. Phys. (IF 5.5) Pub Date : 2024-03-17 Wannes Swinnen, Eline Lievens, Wouter Hoogkamer, Friedl De Groote, Wim Derave, Benedicte Vanwanseele
-
Cyclic nucleotide-induced bidirectional long-term synaptic plasticity in Drosophila mushroom body J. Phys. (IF 5.5) Pub Date : 2024-03-15 Daichi Yamada, Andrew M. Davidson, Toshihide Hige
-
Physical inactivity causes exercise resistance of fat metabolism: harbinger or culprit of disease? J. Phys. (IF 5.5) Pub Date : 2024-03-13 Edward F. Coyle
-
Assessment and modelling of the activation-dependent shift in optimal length of the human soleus muscle in vivo J. Phys. (IF 5.5) Pub Date : 2024-03-14 Sebastian Bohm, Arno Schroll, Falk Mersmann, Adamantios Arampatzis
-
A machine-learning tool to identify bistable states from calcium imaging data J. Phys. (IF 5.5) Pub Date : 2024-03-14 Aalok Varma, Sathvik Udupa, Mohini Sengupta, Prasanta Kumar Ghosh, Vatsala Thirumalai
-
How preserved is right ventricular reserve in hypoxia? J. Phys. (IF 5.5) Pub Date : 2024-03-13 Stephen P. Wright, Tony G. Dawkins
The right ventricle (RV) utilizes oxygen to perform the work that drives blood through the pulmonary vasculature for gas exchange. The vasculature normally has high capacitance to receive pulsatile inflow and offers low resistance while conducting steady flow through the microcirculation. As such, modest RV systolic performance is required to develop pressure and eject stroke volume against low afterload
-
Circadian patterns of behaviour change during pregnancy in mice J. Phys. (IF 5.5) Pub Date : 2024-03-13 Georgia S. Clarke, Andrew D. Vincent, Sharon R. Ladyman, Kathryn L. Gatford, Amanda J. Page
-
FGF2 gene's antisense protein, NUDT6, plays a depressogenic role by promoting inflammation and suppressing neurogenesis without altering FGF2 signalling J. Phys. (IF 5.5) Pub Date : 2024-03-11 Burak Uzay, Aslıhan Bahadır-Varol, Fatma Özlem Hökelekli, Murat Yılmaz, Emre Cem Esen, Koray Başar, Yavuz Ayhan, Turgay Dalkara, Emine Eren-Koçak
-
PIEZO ion channels: force sensors of the interoceptive nervous system J. Phys. (IF 5.5) Pub Date : 2024-03-08 Yasmeen M. F. Hamed, Britya Ghosh, Kara L. Marshall
-
Reduction of left ventricular diastolic pressure as a key regulator of infarct coronary flow under mechanical left ventricular support J. Phys. (IF 5.5) Pub Date : 2024-03-08 Tomoki Sakata, Spyros A. Mavropoulos, Renata Mazurek, Francisco J. Romeo, Anjali J. Ravichandran, Jonas M. Marx, Taro Kariya, Kiyotake Ishikawa
-
Ocular surface information seen from the somatosensory thalamus and cortex J. Phys. (IF 5.5) Pub Date : 2024-03-08 Enrique Velasco, Marta Zaforas, M. Carmen Acosta, Juana Gallar, Juan Aguilar
-
Postsynaptic β1 spectrin maintains Na+ channels at the neuromuscular junction J. Phys. (IF 5.5) Pub Date : 2024-03-05 Ozlem Sert, Xiaoyun Ding, Chuansheng Zhang, Ruifa Mi, Ahmet Hoke, Matthew N. Rasband
-
The pathogenic roles of the p.R130S prestin variant in DFNB61 hearing loss J. Phys. (IF 5.5) Pub Date : 2024-03-03 Satoe Takahashi, Yingjie Zhou, Mary Ann Cheatham, Kazuaki Homma
-
Cathodal bilateral transcranial direct-current stimulation regulates selenium to confer neuroprotection after rat cerebral ischaemia–reperfusion injury J. Phys. (IF 5.5) Pub Date : 2024-03-03 Hui Wang, Wenlong Ma, Wenjie Hu, Xiaohua Li, Na Shen, Zhuo Li, Xiangyi Kong, Tao Lin, Jingchen Gao, Ting Zhu, Fengyuan Che, Juan Chen, Qi Wan
-
Reorganization of mitochondria–organelle interactions during postnatal development in skeletal muscle J. Phys. (IF 5.5) Pub Date : 2024-03-01 Yuho Kim, Hailey A. Parry, T. Bradley Willingham, Greg Alspaugh, Eric Lindberg, Christian A. Combs, Jay R. Knutson, Christopher K. E. Bleck, Brian Glancy
-
The Bayliss–Starling Prize Lecture: The developmental physiology of spinal cord and cortical nociceptive circuits J. Phys. (IF 5.5) Pub Date : 2024-03-01 Maria Fitzgerald
-
The role of CFTR in diabetes-induced pancreatic ductal dysfunction J. Phys. (IF 5.5) Pub Date : 2024-02-29 Oleg V. Gerasimenko, Julia V. Gerasimenko
The pancreas is a vital organ with dual functions, serving both exocrine and endocrine roles. The exocrine pancreas is responsible for the production and secretion of digestive enzymes and fluids by pancreatic acinar cells (PACs) followed by supplementation with bicarbonate (HCO3−) and delivery by the pancreatic duct to the duodenum, aiding food digestion (Petersen et al., 2021). The endocrine pancreas
-
Thermal physiology is a (wo)man's world! J. Phys. (IF 5.5) Pub Date : 2024-02-29 Davide Filingeri, Hannah Blount, Jade Ward
Women undergo unique anatomical, physiological and hormonal changes across their lifespan. For example, consider the impact of the menstrual cycle, pregnancy and menopause, all of which are accompanied by both short- and long-term effects on women's body morphology (e.g. changes in breast size, hip angle, muscle development) as well as on their body temperature regulation, heat tolerance and thermal
-
Effects of periodic breathing on sleep at high altitude: a randomized, placebo-controlled, crossover study using inspiratory CO2 J. Phys. (IF 5.5) Pub Date : 2024-02-26 Abubaker Ibrahim, Ambra Stefani, Matteo Cesari, Johanna Roche, Hannes Gatterer, Evi Holzknecht, Rachel Turner, Giovanni Vinetti, Michael Furian, Anna Heidbreder, Birgit Högl, Christoph Siebenmann
-
Right ventricular performance during acute hypoxic exercise J. Phys. (IF 5.5) Pub Date : 2024-02-26 Lindsay M. Forbes, Todd M. Bull, Tim Lahm, Tyler Sisson, Katie O'Gean, Justin S. Lawley, Kendall Hunter, Benjamin D. Levine, Andrew Lovering, Robert C. Roach, Andrew W. Subudhi, William K. Cornwell
-
Conserved mammalian muscle mechanics during eccentric contractions J. Phys. (IF 5.5) Pub Date : 2024-02-24 Roger W. P. Kissane, Graham N. Askew
-
Orexinergic neurons contribute to autonomic cardiovascular regulation for locomotor exercise J. Phys. (IF 5.5) Pub Date : 2024-02-21 Emi Narai, Yuki Yoshimura, Takaho Honaga, Hiroyuki Mizoguchi, Akihiro Yamanaka, Takeshi Y. Hiyama, Tatsuo Watanabe, Satoshi Koba
-
Neuropilin-1 regulates renin synthesis in juxtaglomerular cells J. Phys. (IF 5.5) Pub Date : 2024-02-21 Yunzhu Shen, Kenza Lotenberg, Jeremy Zaworski, Katharina A.-E. Broeker, Florence Vasseur, Liliane Louedec, Sandrine Placier, Perrine Frère, Marie-Christine Verpont, Pierre Galichon, David Buob, Juliette Hadchouel, Fabiola Terzi, Christos Chatziantoniou, Amélie Calmont
-
Vagotomy blunts cardiorespiratory responses to vagal afferent stimulation via pre- and postsynaptic effects in the nucleus tractus solitarii J. Phys. (IF 5.5) Pub Date : 2024-02-20 Gabrielle C. Hofmann, Procopio Gama de Barcellos Filho, Fateme Khodadadi, Daniela Ostrowski, David D. Kline, Eileen M. Hasser
-
In vivo treatment with calcilytic of CaSR knock-in mice ameliorates renal phenotype reversing downregulation of the vasopressin-AQP2 pathway J. Phys. (IF 5.5) Pub Date : 2024-02-17 Marianna Ranieri, Ines Angelini, Mariagrazia D'Agostino, Annarita Di Mise, Mariangela Centrone, Maria Venneri, Angela Ferrulli, Maria Mastrodonato, Grazia Tamma, Itsuro Endo, Seiji Fukumoto, Toshio Matsumoto, Giovanna Valenti
-
Role of CFTR in diabetes-induced pancreatic ductal fluid and HCO3− secretion J. Phys. (IF 5.5) Pub Date : 2024-02-22 Attila Ébert, Eleonóra Gál, Emese Tóth, Titanilla Szögi, Péter Hegyi, Viktória Venglovecz
-
Residual force depression is not related to positive muscle fascicle work during submaximal voluntary dorsiflexion contractions in humans J. Phys. (IF 5.5) Pub Date : 2024-02-21 Brent James Raiteri, Leon Lauret, Daniel Hahn
-
In vivo mitochondria-targeted protection against uterine artery vascular dysfunction and remodelling in rodent hypoxic pregnancy J. Phys. (IF 5.5) Pub Date : 2024-02-21 Zhongchao Wang, Emily J. Camm, Anna Maria Nuzzo, Ana-Mishel Spiroski, Katie L. Skeffington, Thomas J. Ashmore, Alessandro Rolfo, Tullia Todros, Angela Logan, Jin Ma, Michael P. Murphy, Youguo Niu, Dino A. Giussani