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Mitophagy modulation for the treatment of cardiovascular diseases Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-03-26 Maurizio Forte, Luca D'Ambrosio, Gabriele G. Schiattarella, Nadia Salerno, Marco Alfonso Perrone, Francesco S. Loffredo, Edoardo Bertero, Kalliopi Pilichou, Girolamo Manno, Valentina Valenti, Luigi Spadafora, Marco Bernardi, Beatrice Simeone, Gianmarco Sarto, Giacomo Frati, Cinzia Perrino, Sebastiano Sciarretta
Defects of mitophagy, the selective form of autophagy for mitochondria, are commonly observed in several cardiovascular diseases and represent the main cause of mitochondrial dysfunction. For this reason, mitophagy has emerged as a novel and potential therapeutic target.
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Myosteatosis predicts postoperative complications and long‐term survival in robotic gastrectomy for gastric cancer: A propensity score analysis Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-03-27 Pingan Ding, Jiaxiang Wu, Haotian Wu, Tongkun Li, Jiaxuan Yang, Li Yang, Honghai Guo, Yuan Tian, Peigang Yang, Lingjiao Meng, Qun Zhao
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Oestradiol and osteoclast differentiation: Effects on p53 and mitochondrial metabolism Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-03-23 Adriana Marques‐Carvalho, Beatriz Silva, Francisco B. Pereira, Ha‐Neui Kim, Maria Almeida, Vilma A. Sardão
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Enhancing patient outcomes: Integrating electronic cardiology consultation in primary care for cancer patients Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-03-23 Sergio Cinza‐Sanjurjo, Pilar Mazón‐Ramos, Daniel Rey‐Aldana, David Garcia‐Vega, Manuel Portela‐Romero, Moisés Rodríguez‐Mañero, Manuela Sestayo‐Fernández, Ricardo Lage‐Fernández, Rafael López‐López, José R. González‐Juanatey
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Echinacoside promotes osteogenesis and angiogenesis and inhibits osteoclast formation Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-03-19 Qingqing Yi, Miaomiao Sun, Guowei Jiang, Pengchen Liang, Qing Chang, Rong Yang
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Treatment and outcomes of patients with chronic lung disease and acute myocardial infarction: Insights from the nationwide AMIS plus registry Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-03-14 C. Beckmann, F. Foster‐Witassek, M. Brutsche, M. T. Maeder, F. Eberli, M. Roffi, G. Pedrazzini, D. Radovanovic, H. Rickli
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Prolactin effects on the pathogenesis of diabetes mellitus Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-03-12 Roberta Scairati, Renata Simona Auriemma, Guendalina Del Vecchio, Sara Di Meglio, Rosario Pivonello, Annamaria Colao
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Elevated factor XI is associated with recurrent left ventricular thrombus of unknown origin Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-03-11 Łukasz Zandecki, Michał Ząbczyk, Anetta Undas
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Focal high‐intensity focused ultrasound therapy for localized prostate cancer: An interim analysis of the multinational FASST study Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-03-06 Sam Ladjevardi, Anna Ebner, Aleksandar Femic, Nicolai A. Huebner, Shahrokh F. Shariat, Simon Kraler, Rahel A. Kubik‐Huch, Rafaele C. Ahlman, Michael Häggman, Lukas J. Hefermehl
BackgroundHigh‐intensity focused ultrasound (HIFU) emerged as a novel approach for the treatment of localized prostate cancer (PCa). However, prospective studies on HIFU‐related outcomes and predictors of treatment failure (TF) remain scarce.Materials and MethodsWe conducted a multinational prospective cohort study among patients undergoing HIFU therapy for localized, low‐ to intermediate‐risk PCa
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Genetics of inborn errors of immunity: Diagnostic strategies and new approaches to CNV detection Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-03-05 Elisabet Matas Pérez, Andrea González Torbay, Mario Solis López, Ricardo Cuesta Martín de la Cámara, Carmen Rodríguez Jiménez, Mari Ángeles Mori Álvarez, Julián Nevado Blanco, Carla Gianelli, Carmen Cámara Hijón, Eduardo López Granados, Rebeca Rodríguez Pena, Ángela del Pozo Mate, María Bravo García‐Morato
BackgroundGenetic diagnosis of inborn errors of immunity (IEI) is complex due to the large number of genes involved and their molecular features. Missense variants have been reported as the most common cause of IEI. However, the frequency of copy number variants (CNVs) may be underestimated since their detection requires specific quantitative techniques. At this point, the use of Next Generation Sequencing
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Associations of 50 modifiable risk factors with atrial fibrillation using Mendelian randomization analysis Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-03-05 Zhuxin Zhang, Le Li, Zhenhao Zhang, Zhao Hu, Yulong Xiong, Likun Zhou, Yan Yao
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No evidence linking sleep traits with white blood cell counts: Multivariable‐adjusted and Mendelian randomization analyses Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-03-02 Raymond Noordam, Linjun Ao, Jasmijn F. Stroo, Ko Willems van Dijk, Diana van Heemst
BackgroundDisturbances in habitual sleep have been associated with multiple age‐associated diseases. However, the biological mechanisms underpinning these associations remain largely unclear. We assessed the possible involvement of the circulating immune system by determining the associations between sleep traits and white blood cell counts using multivariable‐adjusted linear regression and Mendelian
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Targeting nicotinamide N‐methyltransferase decreased aggressiveness of osteosarcoma cells Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-03-01 E. N. Serritelli, D. Sartini, R. Campagna, V. Pozzi, N. I. Martin, M. J. van Haren, E. Salvolini, M. Cecati, C. Rubini, M. Emanuelli
BackgroundOsteosarcoma (OS) is a primary bone malignancy that mostly affects young people, characterized by high metastatic potential, and a marked chemoresistance that is responsible for disease relapse in most patients. Therefore, it is necessary to identify novel molecules to setup targeted strategies to improve the clinical outcome. The enzyme nicotinamide N‐methyltransferase (NNMT) catalyses the
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CEACAM1: Shielding the liver against fibrosis Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-03-01 Kezhong Zhang
CONFLICT OF INTEREST STATEMENT The author discloses no conflicts.
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Financial conflicts of interest among presenters, panellists and moderators at haematology and oncology FDA workshops Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-02-26 Sarah L. Miller, Alyson Haslam, Vinay Prasad
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Current policies of non‐commercial funders towards transparency in clinical trials Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-02-24 Rafael Dal‐Ré
CONFLICT OF INTEREST STATEMENT None.
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Increased prevalence of high‐risk coronary plaques in metabolic dysfunction associated steatotic liver disease patients: A meta‐analysis Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-02-24 Ovidio De Filippo, Gianluca Di Pietro, Marco Nebiolo, Davide Giuseppe Ribaldone, Marco Gatti, Francesco Bruno, Guglielmo Gallone, Angelo Armandi, Lucia Ilaria Birtolo, Veronica Zullino, Gianluca Mennini, Stefano Ginanni Corradini, Massimo Mancone, Elisabetta Bugianesi, Mario Iannaccone, Gaetano Maria De Ferrari, Fabrizio D'Ascenzo
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Loss of CEACAM1 in hepatocytes causes hepatic fibrosis Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-02-21 Sobia Zaidi, Suman Asalla, Harrison T. Muturi, Lucia Russo, Raziyeh Abdolahipour, Getachew Debas Belew, Maria Benitez Iglesias, Mary Feraudo, Lensay Leon, Enoch Kuo, Xiuli Liu, Sivarajan Kumarasamy, Hilda E. Ghadieh, Cara Gatto‐Weis, Ali Zarrinpar, Sergio Duarte, Sonia M. Najjar
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Niche for polyamine inhibition in treatment of metastatic pheochromocytoma and paraganglioma Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-02-21 Hans K. Ghayee, Heather Hatch, Raymond J. Bergeron, Katerina Hadrava Vanova, Karel Pacak, Sergei Tevosian
CONFLICT OF INTEREST STATEMENT HKG has received royalties from the University of Texas Southwestern Medical Center at Dallas.
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Large language models for science and medicine Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-02-21 Amalio Telenti, Michael Auli, Brian L. Hie, Cyrus Maher, Suchi Saria, John P. A. Ioannidis
Large language models (LLMs) are a type of machine learning model that learn statistical patterns over text, such as predicting the next words in a sequence of text. Both general purpose and task‐specific LLMs have demonstrated potential across diverse applications. Science and medicine have many data types that are highly suitable for LLMs, such as scientific texts (publications, patents and textbooks)
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miR‐619‐5p and cardiogenic shock in patients with ST‐segment elevation myocardial infarction Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-02-20 Rafael Escate, Teresa Padró, Rosa Suades, Jordi Sans‐Roselló, Yvan Devaux, Päivi Lakkisto, Veli‐Pekka Harjola, Alessandro Sionis, Lina Badimon
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Upper gastrointestinal haemorrhage patients' survival: A causal inference and prediction study Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-02-20 Fuxing Deng, Yaoyuan Cao, Shuangping Zhao
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Synergetic impact of lipoprotein(a) and fibrinogen on stroke in coronary artery disease patients Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-02-16 Cheng Yang, Cheng-Gang Zhu, Yong-Gang Sui, Yuan-Lin Guo, Na-Qiong Wu, Qian Dong, Rui-Xia Xu, Jie Qian, Jian-Jun Li
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Systemic biomarker associated with poor outcome after futile reperfusion Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-02-15 Pablo Hervella, Ana Sampedro-Viana, Manuel Rodríguez-Yáñez, Iria López-Dequidt, José M. Pumar, Antonio J. Mosqueira, Sabela Fernández-Rodicio, Marcos Bazarra-Barreiros, Joaquín Serena, Yolanda Silva-Blas, Carme Gubern-Merida, Daniel Rey-Aldana, Sergio Cinza, Francisco Campos, Tomás Sobrino, José Castillo, Maria Luz Alonso-Alonso, Ramón Iglesias-Rey
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Hyperventilation testing in the diagnosis of vasospastic angina: A clinical review and meta-analysis Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-02-13 Laurie-Anne Boivin-Proulx, Guillaume Marquis-Gravel, Nicolas Rousseau-Saine, François Harel, E. Marc Jolicoeur, Matthieu Pelletier-Galarneau
Given the limited access to invasive vasospastic reactivity testing in Western Countries, there is a need to further develop alternative non-invasive diagnostic methods for vasospastic angina (VSA). Hyperventilation testing (HVT) is defined as a class IIa recommendation to diagnose VSA by the Japanese Society of Cardiology.
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Pulmonary thrombosis associated with COVID-19 pneumonia: Beyond classical pulmonary thromboembolism Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-02-09 Carla Suárez-Castillejo, Néstor Calvo, Luminita Preda, Nuria Toledo-Pons, Aina Rosa Millán-Pons, Joaquín Martínez, Luisa Ramón, Amanda Iglesias, Daniel Morell-García, Josep Miquel Bauça, Belén Núñez, Jaume Sauleda, Ernest Sala-Llinas, Alberto Alonso-Fernández
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Altered left atrial metrics in patients with cryptogenic stroke: A systematic review and meta-analysis Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-02-02 Amy Clark, Aaisha Ferkh, Jamie Vandenberg, James Elhindi, Liza Thomas
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Hydrocortisone cardioprotection in ischaemia/reperfusion injury involves antioxidant mechanisms Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-31 Daiana S. Escudero, Juliana C. Fantinelli, Valeria R. Martínez, Luisa F. González Arbeláez, María E. Amarillo, Néstor G. Pérez, Romina G. Díaz
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From A to E: Uniting vitamins against stroke risk—A systematic review and network meta-analysis Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-30 Shashank Tripathi, Manabesh Nath, Shubham Misra, Pradeep Kumar
Stroke represents a significant public health challenge, necessitating the exploration of preventive measures. This network meta-analysis aimed to assess the efficacy of different vitamin treatments compared to a placebo in preventing stroke.
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Mitochondrial HER2 stimulates respiration and promotes tumorigenicity Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-30 Eliska Novotna, Mirko Milosevic, Dana Prukova, Silvia Magalhaes-Novais, Sarka Dvorakova, Kristina Dmytruk, Jakub Gemperle, Dagmar Zudova, Tereza Nickl, Marek Vrbacky, Daniel Rosel, Vlada Filimonenko, Jan Prochazka, Jan Brabek, Jiri Neuzil, Katerina Rohlenova, Jakub Rohlena
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Clinical impact of cerebral protection during transcatheter aortic valve implantation Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-25 Fabiola Boccuto, Nicole Carabetta, Michele Antonio Cacia, Sai Gautham Kanagala, Giuseppe Panuccio, Daniele Torella, Salvatore De Rosa
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Aspirin loading and coronary no-reflow after percutaneous coronary intervention in patients with acute myocardial infarction Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-24 Gjin Ndrepepa, Salvatore Cassese, Erion Xhepa, Michael Joner, Hendrik B. Sager, Sebastian Kufner, Karl-Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati
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Use of artificial intelligence and radiomics for risk stratification in patients with pulmonary embolism: New tools for an old problem Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-24 Davide Santagata, Marco Paolo Donadini, Walter Ageno
CONFLICT OF INTEREST STATEMENT Walter Ageno: research support from Bayer and advisory boards for Astra Zeneca, Bayer, BMS-Pfizer, Norgine, Sanofi, Techdow, Viatris. Davide Santagata: nothing to disclose. Marco Paolo Donadini: nothing to disclose.
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Plasma lipoprotein(a) is associated with calcification activity of the thoracic aorta and aortic valve in statin naïve individuals with diabetes mellitus Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-24 Jamie W. Bellinge, Dick C. Chan, Jing Pang, Roslyn J. Francis, Michael M. Page, Gerald F. Watts, Carl J. Schultz
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Osteopontin is associated with neutrophil extracellular trap formation in elderly patients with severe sepsis Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-24 Maria Bertolotto, Daniela Verzola, Paola Contini, Daniela de Totero, Amedeo Tirandi, Davide Ramoni, Stefano Ministrini, Daniele Roberto Giacobbe, Aldo Bonaventura, Alessandra Vecchié, Luca Castellani, Michele Mirabella, Eleonora Arboscello, Luca Liberale, Francesca Viazzi, Matteo Bassetti, Fabrizio Montecucco, Federico Carbone
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Association of Lipoprotein(a) with arterial stiffness: A Mendelian randomization study Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-18 Alexandros Simistiras, Georgios Georgiopoulos, Dimitrios Delialis, Georgios Mavraganis, Ermioni Oikonomou, Eleni Maneta, Christos Loutos, Evangelos Evangelou, Kimon Stamatelopoulos
In this study we used Mendelian randomization (MR) to investigate the potential causal association of lipoprotein (a) [Lp(a)] levels with pulse wave velocity (PWV).
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Association of metabolic health and obesity with coronary heart disease in adult cancer survivors Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-18 Kyuwoong Kim, Edvige Di Giovanna, Hyeyun Jung, Lakshimi Deepak Bethineedi, Tae Joon Jun, Young-Hak Kim
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The association between the basal metabolic rate and cardiovascular disease: A two-sample Mendelian randomization study Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-17 Kaijie Chen, Yue Zhang, Siyu Zhou, Chengjiang Jin, Meixiang Xiang, Hong Ma
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Effect of statins on sepsis and inflammatory factors: A Mendelian randomization study Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-16 Kai Zhang, Wei Liu, Hongjin Liang
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2023 focused update of the 2021 ESC heart failure guidelines: Key messages for clinical practice Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-18 Daniela Tomasoni, Antonio Cannatà, Marianna Adamo, Marco Metra
CONFLICT OF INTEREST STATEMENT DT reports personal fees from Alnylam Pharmaceuticals, Boehringer Ingelheim and Pfizer outside the submitted work. MA reports speaker fees from Abbott Vascular and Medtronic. MM reports personal consulting honoraria of minimal amount from Abbott, Amgen, Bayer, Edwards Therapeutics, LivaNova and Vifor Pharma for participation to advisory board meetings and executive committees
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The sodium–chloride difference: A marker of prognosis in patients with acute myocardial infarction Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-16 Michał Terlecki, Maryla Kocowska-Trytko, Aleksandra Kurzyca, Christopher Pavlinec, Maciej Zając, Jakub Rusinek, Paweł Lis, Adam Bednarski, Wiktoria Wojciechowska, Katarzyna Stolarz-Skrzypek, Marek Rajzer
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The association between atrial fibrillation and dementia: A UK linked electronic health records cohort study Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-13 Kieran Brooks, Hiroyuki Yoshimura, Arturo Gonzalez-Izquierdo, Nadine Zakkak, Kishore Kukendra-Rajah, Gregory Y. H. Lip, Rui Providencia
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Neutrophil degranulation, endothelial and metabolic dysfunction in unvaccinated long COVID patients Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-16 Agostino Di Ciaula, Luca Liberale, Piero Portincasa, Mohamad Khalil, Ilaria Galerati, Ilaria Farella, Antonino Noto, Stephy JohnBritto, Margherita Moriero, Cristina Michelauz, Federica Frè, Chiara Olivero, Maria Bertolotto, Fabrizio Montecucco, Federico Carbone, Leonilde Bonfrate
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Early diagnosis and management of cardiac amyloidosis: A clinical perspective Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-12 Ilaria Anna Bellofatto, Thomas H. Schindler, Piero Portincasa, Federico Carbone, Marco Canepa, Luca Liberale, Fabrizio Montecucco
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Abnormal circulating steroids refine risk of progression to heart failure in ischemic heart disease Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-12 Yangkai Fan, Fengjuan Li, Xin Tan, Lu Ren, Xueyan Peng, Jiaqi Yu, Weiyao Chen, Lixin Jia, Fuli Zhu, Wenjie Yin, Jie Du, Yuan Wang
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Educational status affects prognosis of patients with heart failure with reduced ejection fraction: A post-hoc analysis from the WARCEF trial Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-11 Bernadette Corica, Giulio Francesco Romiti, Amalie Helme Simoni, Davide Antonio Mei, Tommaso Bucci, John L. P. Thompson, Min Qian, Shunichi Homma, Marco Proietti, Gregory Y. H. Lip
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Transsulfuration and folate pathways in rheumatoid arthritis: A systematic review and meta-analysis Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-12 Arduino A. Mangoni, Angelo Zinellu
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Six-minute walking distance and desaturation–distance ratio in allogeneic stem cell transplantation Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2024-01-09 Yolanda Torralba-García, Xavier Alsina-Restoy, Rodrigo Torres-Castro, Elena Gimeno-Santos, Noemi de Llobet-Viladons, Montserrat Rovira-Tarrats, Nuria Borràs-Maixenchs, Montserrat Valverde-Bosch, Carles Agustí García-Navarro, Jordi Vilaró, Isabel Blanco
Most patients with haematological malignancies who undergo allogeneic haematopoietic stem cell transplant (HSCT) receive chemotherapy before the transplant to control the disease. Certain chemotherapy drugs can cause lung toxicity. Conversely, in patients with chronic respiratory conditions, the 6-min walking test (6MWT) and the desaturation–distance ratio (DDR) have demonstrated prognostic significance
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Sentinel lymph node biopsy for breast cancer during pregnancy: A comprehensive update Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2023-12-14 Αnastasia Bothou, Chrysoula Margioula-Siarkou, Stamatios Petousis, Georgia Margioula-Siarkou, Stefanos Zervoudis, Alexandros Sotiriadis, Fréderic Amant, Konstantinos Dinas
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Circulating haematopoietic stem cells and long-term outcomes of COVID-19 Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2023-12-13 Benedetta Maria Bonora, Marella Marassi, Paola Fogar, Jenny Zuin, Roberta Cappellari, Serena Marinello, Anna Ferrari, Annamaria Cattelan, Angelo Avogaro, Daniela Basso, Gian Paolo Fadini
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Serological markers and long COVID—A rapid systematic review Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2023-12-11 Erin Collins, Elizabeth Philippe, Christopher A. Gravel, Steven Hawken, Marc-André Langlois, Julian Little
Long COVID is highly heterogeneous, often debilitating, and may last for years after infection. The aetiology of long COVID remains uncertain. Examination of potential serological markers of long COVID, accounting for clinical covariates, may yield emergent pathophysiological insights.
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Recent advances in mechanistic studies of heart failure with preserved ejection fraction and its comorbidities—Role of microRNAs Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2023-12-09 Xiaonan Li, Min Sun, Zhe Wang, Siming Sun, Yuehui Wang
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Vitamin K insufficiency and the prophylaxis strategy in term healthy infants: A multicentre study Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2023-12-09 Serafina Perrone, Giuseppe De Bernardo, Chiara Lembo, Valentina Dell'Orto, Maurizio Giordano, Virginia Beretta, Chiara Petrolini, Lucia Gambini, Anna Laura Toni, Gianni Parigi, Ilenia Fontanarosa, Maria Pia Natale, Gabriele D'Amato, Desiree Sordino, Giuseppe Buonocore
Late vitamin K deficiency bleeding (VKDB) during early infancy is a serious problem worldwide. Vitamin K (VK) deficiency commonly occurs in newborns who are exclusively breastfed. Protein Induced by VK Absence (PIVKA-II) has been identified as an early indicator of subclinical VK deficiency in neonates, surpassing prothrombin time. To assess PIVKA-II levels at 48 h, 1 and 3 months of age in full-term
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Serum bile acids associate with liver volume in polycystic liver disease and decrease upon treatment with lanreotide Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2023-12-09 Shosha E. I. Dekker, Jörgen Bierau, Martin Giera, Niek Blomberg, Joost P. H. Drenth, Oleg A. Mayboroda, Johan W. de Fijter, Darius Soonawala
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HLA binding-groove motifs are associated with myocarditis induction after Pfizer-BioNTech BNT162b2 vaccination Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2023-12-09 Aviran Aharon, Gil Benedek, Barhoum Barhoum, Elchanan Parnasa, Nur Magadle, Ofer Perzon, Dror Mevorach
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Imaging-based risk stratification of patients with pulmonary embolism based on dual-energy CT-derived radiomics Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2023-12-08 Jennifer Gotta, Vitali Koch, Tobias Geyer, Simon S. Martin, Christian Booz, Scherwin Mahmoudi, Katrin Eichler, Philipp Reschke, Tommaso D'Angelo, Konrad Klimek, Thomas J. Vogl, Leon D. Gruenewald
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Sperm mitochondria dysfunction in response to testicular cancer Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2023-12-08 Maryam Qasemi, Vishma Pratap Sur, Ondrej Simonik, Pavla Postlerova, Pavel Skrobanek, Tomas Hradec, Ludmila Boublikova, Libor Zamecnik, Tomas Buchler, Jiri Neuzil, Katerina Komrskova
Testicular cancer is the most common form of cancer in young men of reproductive age and its incidence is increasing globally. With the currently successful treatment and 95% survival rate, there is a need for deeper understanding of testicular cancer-related infertility. Most patients with testicular cancer experience semen abnormalities prior to cancer therapy. However, the exact mechanism of the
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Effects of CASZ1, WNT2B and PTPRG SNPs on stroke susceptibility in the Chinese Han population Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2023-12-07 Huan Zhang, Yanting Chang, Yujie Li, Jie Wei, Xiaoya Ma, Wenqian Zhou, Xufeng Zang, Tianbo Jin, Songdi Wu
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Reading 2023 ESC ACS guidelines between the lines: Gaps in evidence in women Eur. J. Clin. Investig. (IF 5.5) Pub Date : 2023-12-06 Graziella Pompei, Tim P. van de Hoef, Hester M. den Ruijter, Vijay Kunadian
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest.