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Evaluating Linkage Quality of Population-Based Administrative Data for Health Service Research. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-04-15 Ji-Woo Kim, Hyojung Choi, Hyun Jeung Lim, Miae Oh, Jae Joon Ahn
To overcome the limitations of relying on data from a single institution, many researchers have studied data linkage methodologies. Data linkage includes errors owing to legal issues surrounding personal information and technical issues related to data processing. Linkage errors affect selection bias, and external and internal validity. Therefore, quality verification for each connection method with
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Comparative Analysis of Clinical Outcomes Using Propensity Score Matching: Coronavirus Disease 2019 vs. Seasonal Influenza in Korea. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-04-15 Jae Kyeom Sim, Hye Sun Lee, Juyeon Yang, Jin Gwack, Bryan Inho Kim, Jeong-Ok Cha, Kyung Hoon Min, Young Seok Lee
The advent of the omicron variant and the formulation of diverse therapeutic strategies marked a new epoch in the realm of coronavirus disease 2019 (COVID-19). Studies have compared the clinical outcomes between COVID-19 and seasonal influenza, but such studies were conducted during the early stages of the pandemic when effective treatment strategies had not yet been developed, which limits the generalizability
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Antimicrobial Use and Carbapenem-Resistant Enterobacterales in Korea: A Nationwide Case-Control Study With Propensity Score Matching. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-04-15 Ki Tae Kwon, Yoonjung Kim, Shin-Woo Kim, Hyun-Ha Chang, Soyoon Hwang, Sohyun Bae, Eunkyung Nam
Nationwide research on the association between carbapenem-resistant Enterobacterales (CREs) and antibiotic use is limited.
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Review of COVID-19 Therapeutics by Mechanism: From Discovery to Approval. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-04-15 Hee Sun Choi, A Young Choi, Jeffrey B Kopp, Cheryl A Winkler, Sung Kweon Cho
The global research and pharmaceutical community rapidly mobilized to develop treatments for coronavirus disease 2019 (COVID-19). Existing treatments have been repurposed and new drugs have emerged. Here we summarize mechanisms and clinical trials of COVID-19 therapeutics approved or in development. Two reviewers, working independently, reviewed published data for approved COVID-19 vaccines and drugs
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Comparison of the Clinical Outcomes Between Early and Delayed Transplantation After SARS-CoV-2 Infection. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-04-15 Sang Hyun Ra, A Reum Kim, Hyeon Mu Jang, Euijin Chang, Seongman Bae, Jiwon Jung, Min Jae Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Sung-Han Kim
Our study analyzed 95 solid organ transplant (SOT) and 78 hematopoietic stem cell transplant (HSCT) recipients with prior coronavirus disease 2019 (COVID-19). Patients who underwent transplantation within 30 days of COVID-19 infection comprised the early group, and those who underwent transplantation post-30 days of COVID-19 infection comprised the delayed group. In the early transplantation group
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Application of the Hollow-Fiber Infection Model to Personalized Precision Dosing of Isoniazid in a Clinical Setting. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-04-08 Yumi Park, Pham My Tung, Nguyen Ky Anh, Yong-Soon Cho, Jae-Gook Shin
The hollow-fiber infection model (HFIM) is a valuable tool for evaluating pharmacokinetics/pharmacodynamics relationships and determining the optimal antibiotic dose in monotherapy or combination therapy, but the application for personalized precision medicine in tuberculosis treatment remains limited. This study aimed to evaluate the efficacy of adjusted antibiotic doses for a tuberculosis patient
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Prevalence and Associated Factors of Depression and Anxiety Among Healthcare Workers During the Coronavirus Disease 2019 Pandemic: A Nationwide Study in Korea. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-04-08 Shinwon Lee, Soyoon Hwang, Ki Tae Kwon, EunKyung Nam, Un Sun Chung, Shin-Woo Kim, Hyun-Ha Chang, Yoonjung Kim, Sohyun Bae, Ji-Yeon Shin, Sang-Geun Bae, Hyun Wook Ryoo, Juhwan Jeong, NamHee Oh, So Hee Lee, Yeonjae Kim, Chang Kyung Kang, Hye Yoon Park, Jiho Park, Se Yoon Park, Bongyoung Kim, Hae Suk Cheong, Ji Woong Son, Su Jin Lim, Seongcheol Yun, Won Sup Oh, Kyung-Hwa Park, Ju-Yeon Lee, Sang Taek Heo
A healthcare system's collapse due to a pandemic, such as the coronavirus disease 2019 (COVID-19), can expose healthcare workers (HCWs) to various mental health problems. This study aimed to investigate the impact of the COVID-19 pandemic on the depression and anxiety of HCWs.
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COVID-19 Vaccine Injury Compensation Program: Lessons Learned From a Review of 10 Implementing Countries. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-04-08 Cho Ryok Kang, Young June Choe, Seok-Jun Yoon
National vaccine injury compensation serves as a crucial and significant safety net for individuals affected by government-recommended vaccines during a pandemic, contributing to the community's overall safety. In the Republic of Korea, compensation for adverse events resulting from coronavirus disease 2019 (COVID-19) vaccinations has been provided through the National Vaccine Injury Compensation Program
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Understanding the Fluctuations in Korea's Suicide Rates: A Change-Point Analysis and Interrupted Time Series Analysis. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-04-08 Seunghyong Ryu, Hee Jung Nam, Ju-Yeon Lee, Jae-Min Kim, Sung-Wan Kim
Korea has witnessed significant fluctuations in its suicide rates in recent decades, which may be related to modifications in its death registration system. This study aimed to explore the structural shifts in suicide trends, as well as accidental and ill-defined deaths in Korea, and to analyze the patterns of these changes.
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Association Between Individual Air Pollution (PM10, PM2.5) Exposure and Adverse Pregnancy Outcomes in Korea: A Multicenter Prospective Cohort, Air Pollution on Pregnancy Outcome (APPO) Study. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-04-08 Tae Gyu Ahn, Young Ju Kim, Gain Lee, Young-Ah You, Soo Min Kim, Rin Chae, Young Min Hur, Mi Hye Park, Jin-Gon Bae, Soo-Jeong Lee, Young-Han Kim, Sunghun Na
Prenatal exposure to ambient air pollution is linked to a higher risk of unfavorable pregnancy outcomes. However, the association between pregnancy complications and exposure to indoor air pollution remains unclear. The Air Pollution on Pregnancy Outcomes research is a hospital-based prospective cohort research created to look into the effects of aerodynamically exposed particulate matter (PM)10 and
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Validation of the Pandemic Grief Risk Factors and Its Relationship With Work-Related Stress and Grief Reaction Among Healthcare Workers Who Witnessed Patient Deaths. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-25 C Hyung Keun Park, Soyoung Yoo, Oli Ahmed, Seockhoon Chung, Sherman A Lee
The Pandemic Grief Risk Factors (PGRFs) was developed as a self-report tool to compile a comprehensive list of unique risk factors related to grief when experiencing a coronavirus disease 2019 (COVID-19) loss. We explored the reliability and validity of the PGRF among healthcare workers who witnessed their patients' deaths during the COVID-19 pandemic. Further, we examined whether the general severity
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COVID-19 Outcome and Tobacco Product Use: Case-Control and Retrospective Cohort Studies Using Nationwide Samples. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-25 Seo Young Kang, Ye-Jee Kim, Hong-Jun Cho
Conflicting evidence exists regarding the association between smoking and the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We investigated the association between combustible cigarette (CC) smoking, noncombustible tobacco product (NCTP) use, and the use of any tobacco product with various coronavirus disease 2019 (COVID-19) outcomes.
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Increased Risk of Incident Chronic Obstructive Pulmonary Disease and Related Hospitalizations in Tuberculosis Survivors: A Population-Based Matched Cohort Study. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-25 Taehee Kim, Hayoung Choi, Sang Hyuk Kim, Bumhee Yang, Kyungdo Han, Jin-Hyung Jung, Bo-Guen Kim, Dong Won Park, Ji Yong Moon, Sang-Heon Kim, Tae-Hyung Kim, Ho Joo Yoon, Dong Wook Shin, Hyun Lee
Tuberculosis (TB) survivors have an increased risk of developing chronic obstructive pulmonary disease (COPD). This study assessed the risk of COPD development and COPD-related hospitalization in TB survivors compared to controls.
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Life Expectancy of Patients Undergoing Total Knee Arthroplasty: Comparison With General Population. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-25 Sanghyo Kim, Samuel Jaeyoon Won, Na-Kyoung Lee, Chong Bum Chang
This study aimed to analyze the life expectancy and cause of death in osteoarthritis (OA) patients who underwent total knee arthroplasty (TKA) and to identify risk factors that affect long-term mortality rate after TKA.
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Comparative Analysis of CT Findings and Clinical Outcomes in Adult Patients With Disseminated and Localized Pulmonary Nocardiosis. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-25 Han Na Lee, Kyung-Hyun Do, Eun Young Kim, Jooae Choe, Heungsup Sung, Sang-Ho Choi, Hwa Jung Kim
Pulmonary nocardiosis is a rare opportunistic infection with occasional systemic dissemination. This study aimed to investigate the computed tomography (CT) findings and prognosis of pulmonary nocardiosis associated with dissemination.
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Characteristics According to Frailty Status Among Older Korean Patients With Hypertension. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-18 Jung-Yeon Choi, Hae-Young Lee, Ju-Hee Lee, Youjin Hong, Sue K Park, Dong Ryeol Ryu, Jang Hoon Lee, Seokjae Hwang, Kye Hun Kim, Sun Hwa Lee, Song-Yi Kim, Jae-Hyeong Park, Sang-Hyun Kim, Hack-Lyoung Kim, Jung Hyun Choi, Cheol-Ho Kim, Myeong-Chan Cho, Kwang-Il Kim
As the prevalence of hypertension increases with age and the proportion of the older population is also on the rise, research on the characteristics of older hypertensive patients and the importance of frailty is necessary. This study aimed to identify clinical characteristics of older hypertension in Korea and to investigate these characteristics based on frailty status.
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Risk Factors for Infertility in Korean Women. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-18 Juyeon Lee, Chang-Woo Choo, Kyoung Yong Moon, Sang Woo Lyu, Hoon Kim, Joong Yeup Lee, Jung Ryeol Lee, Byung Chul Jee, Kyungjoo Hwang, Seok Hyun Kim, Sue K Park
Female infertility is a crucial problem with significant implications for individuals and society. In this study, we explore risk factors for infertility in Korean women.
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Nationwide Study of the Epidemiology, Diagnosis, and Treatment of Hypersensitivity Pneumonitis in Korea. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-18 Hae In Jung, Dal Ri Nam, Seung-Hun You, Jae-Woo Jung, Kang-Mo Gu, Sun-Young Jung
Hypersensitivity pneumonitis (HP) is a condition with an uncertain global incidence, and information on its diagnosis and management is limited. This study aimed to address these knowledge gaps.
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Cost-Utility Analysis for Colorectal Cancer Screening According to the Initiating Age of National Cancer Screening Program in Korea. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-18 Seowoo Bae, Kyeongmin Lee, Byung Chang Kim, Jae Kwan Jun, Kui Son Choi, Mina Suh
This study aimed to identify the most cost-effective strategy for colorectal cancer screening using the fecal immunochemical test (FIT), focusing on screening initiation age in Korea.
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Effect of Temperature Variation on the Incidence of Acute Myocardial Infarction. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-18 Cai De Jin, Moo Hyun Kim, Kwang Min Lee, Sung-Cheol Yun
Harsh temperature exposure has been associated with a high risk of cardiovascular events. We sought to investigate the influence of temperature change on long-term incidence of acute myocardial infarction (AMI) in Korean patients.
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Transradial Versus Transfemoral Access for Bifurcation Percutaneous Coronary Intervention Using Second-Generation Drug-Eluting Stent. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-18 Jung-Hee Lee, Young Jin Youn, Ho Sung Jeon, Jun-Won Lee, Sung Gyun Ahn, Junghan Yoon, Hyeon-Cheol Gwon, Young Bin Song, Ki Hong Choi, Hyo-Soo Kim, Woo Jung Chun, Seung-Ho Hur, Chang-Wook Nam, Yun-Kyeong Cho, Seung Hwan Han, Seung-Woon Rha, In-Ho Chae, Jin-Ok Jeong, Jung Ho Heo, Do-Sun Lim, Jong-Seon Park, Myeong-Ki Hong, Joon-Hyung Doh, Kwang Soo Cha, Doo-Il Kim, Sang Yeub Lee, Kiyuk Chang, Byung-Hee
The benefits of transradial access (TRA) over transfemoral access (TFA) for bifurcation percutaneous coronary intervention (PCI) are uncertain because of the limited availability of device selection. This study aimed to compare the procedural differences and the in-hospital and long-term outcomes of TRA and TFA for bifurcation PCI using second-generation drug-eluting stents (DESs).
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Chromosomal Microarray Analysis in Fetuses With Ultrasonographic Soft Markers: A Meta-Analysis of the Current Evidence. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-04 Uisuk Kim, Young Mi Jung, Sohee Oh, Ji Hye Bae, Jeesun Lee, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun, Seung Mi Lee
Ultrasonographic soft markers are normal variants, rather than fetal abnormalities, and guidelines recommend a detailed survey of fetal anatomy to determine the necessity of antenatal karyotyping. Anecdotal reports have described cases with ultrasonographic soft markers in which chromosomal microarray analysis (CMA) revealed pathogenic copy number variants (CNVs) despite normal results on conventional
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Comparison of High- and Low-Dose Rivaroxaban Regimens in Elderly East Asian Patients With Atrial Fibrillation. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-04 Ju Youn Kim, Juwon Kim, Seung-Jung Park, Kyoung-Min Park, June Soo Kim, Sung-Hwan Kim, Jaemin Shim, Eue Keun Choi, Dae-Hyeok Kim, Il-Young Oh, Young Keun On
In the Rivaroxaban Once-daily oral direct factor Xa inhibition Compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) trial, rivaroxaban 20 mg was the on-label dose, and the dose-reduction criterion for rivaroxaban was a creatinine clearance of < 50 mL/min. Some Asian countries are using reduced doses label according to the J-ROCKET AF trial
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Risk Factors for the Mortality of Patients With Coronavirus Disease 2019 Requiring Extracorporeal Membrane Oxygenation in a Non-Centralized Setting: A Nationwide Study. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-04 Tae Wan Kim, Won-Young Kim, Sunghoon Park, Su Hwan Lee, Onyu Park, Taehwa Kim, Hye Ju Yeo, Jin Ho Jang, Woo Hyun Cho, Jin-Won Huh, Sang-Min Lee, Chi Ryang Chung, Jongmin Lee, Jung Soo Kim, Sung Yoon Lim, Ae-Rin Baek, Jung-Wan Yoo, Ho Cheol Kim, Eun Young Choi, Chul Park, Tae-Ok Kim, Do Sik Moon, Song-I Lee, Jae Young Moon, Sun Jung Kwon, Gil Myeong Seong, Won Jai Jung, Moon Seong Baek
Limited data are available on the mortality rates of patients receiving extracorporeal membrane oxygenation (ECMO) support for coronavirus disease 2019 (COVID-19). We aimed to analyze the relationship between COVID-19 and clinical outcomes for patients receiving ECMO.
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Adverse Events Following COVID-19 Vaccination in Adolescents: Insights From Pharmacovigilance Study of VigiBase. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-04 Dong Hyuk Kim, Ju Hwan Kim, In-Sun Oh, Young June Choe, Seung-Ah Choe, Ju-Young Shin
During coronavirus disease 2019 (COVID-19) pandemic, several COVID-19 vaccines were licensed with fast-track procedures. Although these vaccines have demonstrated high immunogenicity, there has been concerns on the serious adverse events (AEs) following COVID-19 vaccination among adolescents. We aimed to analyze comparative safety of COVID-19 vaccination in adolescents.
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Association Between Multiple Heavy Metal Exposures and Cholesterol Levels in Residents Living Near a Smelter Plant in Korea. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-04 Sun-In Moon, Dong-Hyuk Yim, Kyunghi Choi, Sang-Yong Eom, Byung-Sun Choi, Jung-Duck Park, Heon Kim, Yong-Dae Kim
Considering the interactions between heavy metals, a comprehensive evaluation of the effects of exposure to various types of co-interacting heavy metals on health is required. This study assessed the association between dyslipidemia markers and blood mercury, lead, cadmium, iron, zinc, and nickel levels in residents of an abandoned refinery plant.
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Mildly Reduced Renal Function Is Associated With Increased Heart Failure Admissions in Patients With Hypertrophic Cardiomyopathy. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-04 Nan Young Bae, Tae-Min Rhee, Chan Soon Park, You-Jung Choi, Hyun-Jung Lee, Hong-Mi Choi, Jun-Bean Park, Yeonyee E Yoon, Yong-Jin Kim, Goo-Yeong Cho, In-Chang Hwang, Hyung-Kwan Kim
The association between renal dysfunction and cardiovascular outcomes has yet to be determined in patients with hypertrophic cardiomyopathy (HCM). We aimed to investigate whether mildly reduced renal function is associated with the prognosis in patients with HCM.
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Impact of Lactate Dehydrogenase and Hemoglobin Levels on Clinical Outcomes in Patients With Paroxysmal Nocturnal Hemoglobinuria: Results From the National Korean PNH Registry. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-04 Jun Ho Jang, Jin Seok Kim, Cindy Thiow Koon Lim, Nora J Kleinman, Karl-Johan Myren, Alice Wang, Yogesh Patel, Jong Wook Lee
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder caused by uncontrolled terminal complement activation, which leads to intravascular hemolysis (IVH), thromboembolism (TE), renal failure, and premature mortality.
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Adverse Reactions After Intradermal Vaccination With JYNNEOS for Mpox in Korea. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-03-04 So Yun Lim, Yu Mi Jung, Yeonjae Kim, Gayeon Kim, Jaehyun Jeon, BumSik Chin, Min-Kyung Kim
In response to the Mpox domestic epidemic, South Korea initiated a nationwide vaccination program in May 2023, administering a 0.1 mL intradermal dose of JYNNEOS (Modified Vaccinia Ankara vaccine, Bavarian Nordic) to a high-risk group. To investigate the adverse reactions after intradermal JYNNEOS vaccination, an anonymous online survey was conducted at the National Medical Center from May 22 to July
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YouTube as a Source of Information on Public Health Ethics. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-26 Alikhan Zhaksylyk, Marlen Yessirkepov, Ahmet Akyol, Burhan Fatih Kocyigit
Public health ethics (PHE) is a dynamic area within bioethics that addresses the complex moral implications of public health measures in the face of growing health threats. YouTube is a powerful and widely used platform for disseminating health-related information. The primary objective of this study is to assess videos related to PHE on YouTube. The aim is to gauge the extent of misinformation in
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Do Death Certificate Errors Decrease as Clinical Experience in an Emergency Department Increases? J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-26 Jung Jun Kim, Sun Hyu Kim, Sangyup Chung, Byeong Ju Park, Soobeom Park, Song Yi Park
This study aimed to evaluate the relationship between clinical experience and death certificate (DC) errors by analyzing DCs written by experienced emergency physicians (EPs).
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Sextant Systematic Biopsy Versus Extended 12-Core Systematic Biopsy in Combined Biopsy for Prostate Cancer. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-26 Jae Hoon Chung, Wan Song, Minyong Kang, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Byung Kwan Park
This study assessed the comparative effectiveness of sextant and extended 12-core systematic biopsy within combined biopsy for the detection of prostate cancer.
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Current Status of Latent Tuberculosis Infection Treatment Among Pediatric Patients in Korea: Prescription and Treatment Completion. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-26 Yejin Kim, Kil Seong Bae, Ui Yoon Choi, Seung Beom Han, Jong-Hyun Kim
The treatment of pediatric patients with latent tuberculosis infection (LTBI) is a crucial TB control strategy. LTBI is not a reportable communicable disease, and data regarding LTBI treatment in pediatric patients in Korea are scarce. This study aimed to investigate the prescription patterns and treatment completion rates among pediatric patients with LTBI in Korea by analyzing National Health reimbursement
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Measuring the Burden of Disease in Korea Using Disability-Adjusted Life Years (2008-2020). J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-26 Yoon-Sun Jung, Young-Eun Kim, Minsu Ock, Seok-Jun Yoon
The measurement of health levels and monitoring of characteristics and trends among populations and subgroups are essential for informing evidence-based policy decisions. This study aimed to examine the burden of disease in Korea for both the total population and subgroups in 2020, as well as analyze changes in disease burden from 2008 to 2020.
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Differences in Brain Metabolite Profiles Between Normothermia and Hypothermia. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-26 Suk Ho Sohn, Sihyun Chae, Jae Woong Choi, Karam Nam, Youn Joung Cho, Joo-Youn Cho, Ho Young Hwang
This study evaluated the difference in brain metabolite profiles between normothermia and hypothermia reaching 25°C in humans in vivo.
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Trends in Healthy Life Expectancy (HALE) and Disparities by Income and Region in Korea (2008-2020): Analysis of a Nationwide Claims Database. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-19 Yoon-Sun Jung, Young-Eun Kim, Minsu Ock, Seok-Jun Yoon
Healthy life expectancy is a well-recognized indicator for establishing health policy goals used in Korea's Health Plan. This study aimed to explore Koreans' healthy life expectancy and its gender, income, and regional disparities from 2008 to 2020.
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Increased Apolipoprotein B/Apolipoprotein A-I Ratio Is Associated With Decline in Lung Function in Healthy Individuals: The Kangbuk Samsung Health Study. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-19 Jonghoo Lee, Hye Kyeong Park, Min-Jung Kwon, Soo-Youn Ham, Hyun-Il Gil, Si-Young Lim, Jae-Uk Song
Lung dysfunction and high apolipoprotein B/apolipoprotein A-I (apoB/apoA-I) ratio are both recognized risk factors for cardiovascular disease. However, few studies have examined the association between the apoB/ApoA-I ratio and lung function. Therefore, we investigated whether this ratio is associated with decreased lung function in a large healthy cohort.
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Determining and Comparing the Real-World Effectiveness of Molnupiravir and Nirmatrelvir-Ritonavir in Patients Hospitalized With COVID-19. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-19 Young Rock Jang, Yoonju Oh, Jin Yong Kim
Current guidelines recommend using nirmatrelvir-ritonavir for coronavirus disease 2019 (COVID-19) treatment, but its potential drug interactions and contraindications limit its applicability in certain categories of patients. The aim of the study was to evaluate the real-world effectiveness of molnupiravir and nirmatrelvir-ritonavir in managing COVID-19 among hospitalized patients.
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Variation in the Allergenicity of Scrambled, Boiled, Short-Baked and Long-Baked Egg White Proteins. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-19 Purevsan Gantulga, Jeongmin Lee, Kyunguk Jeong, Se-Ah Jeon, Sooyoung Lee
Hen's egg white (HEW) is the most common cause of food allergy in children which induces mild to fatal reactions. The consultation for a proper restriction is important in HEW allergy. We aimed to identify the changes in HEW allergenicity using diverse cooking methods commonly used in Korean dishes.
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Pneumonia Prevalence Upon Chest Radiography According to Vaccination Status Among Patients Under 50 Years of Age With Coronavirus Disease 2019. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-19 Yong Shik Kwon, Sun Hyo Park, Hyun Jung Kim, Jae Seok Park, Mi-Ae Kim, Tae Hun Kim, Ji Yeon Lee, Jin Young Kim
Coronavirus disease 2019 (COVID-19) vaccination is effective in preventing the disease transmission and progression. However, the relatively mild disease course of the omicron variant and the decrease in antibodies over time after vaccination raise questions about the effectiveness of vaccination, especially in young people. We compared the prevalence of pneumonia and chest X-ray severity score according
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Effects of Transport to Trauma Centers on Survival Outcomes Among Severe Trauma Patients in Korea: Nationwide Age-Stratified Analysis. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-19 Hakrim Kim, Kyoung Jun Song, Ki Jeong Hong, Jeong Ho Park, Tae Han Kim, Stephen Gyung Won Lee
Previous studies showed that the prognosis for severe trauma patients is better after transport to trauma centers compared to non-trauma centers. However, the benefit from transport to trauma centers may differ according to age group. The aim of this study was to compare the effects of transport to trauma centers on survival outcomes in different age groups among severe trauma patients in Korea.
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The Impact of Withdrawing or Withholding of Life-Sustaining Treatment: A Nationwide Case-Control Study Based on Medical Cost Analysis. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-19 Claire Junga Kim, Do-Kyong Kim, Sookyeong Mun, Minkook Son
This study measured the impact of the Decisions on Life-Sustaining Treatment Act by analyzing medical cost data from the National Health Insurance Service-National Sample Cohort. After identifying the patients who died in 2018 and 2019, the case and control groups were set using the presence of codes for managing the implementation of life-sustaining treatment with propensity score matching. Regarding
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Erratum: Correction of Tables in the Article "Reference Respiratory Muscle Strength Values and a Prediction Equation Using Physical Functions for Pulmonary Rehabilitation in Korea". J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-19 Tae Sung Park, Young Jin Tak, Youngjin Ra, Jinmi Kim, Sang Hun Han, Sang Hun Kim, YongBeom Shin, Myung-Jun Shin, Jong Ho Kang
This corrects the article on p. e325 in vol. 38, PMID: 37846788.
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Realistic Estimation of COVID-19 Infection by Seroprevalence Surveillance of SARS-CoV-2 Antibodies: An Experience From Korea Metropolitan Area From January to May 2022. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-05 In Hwa Jeong, Jong-Hun Kim, Min-Jung Kwon, Jayoung Kim, Hee Jin Huh, Byoungguk Kim, Junewoo Lee, Jeong-Hyun Nam, Eun-Suk Kang
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally, leading to the coronavirus disease 2019 (COVID-19) pandemic. Because a significant proportion of the COVID-19 confirmed cases were concentrated in the capital metropolitan area of South Korea, and a large proportion of the population in the area had been adequately vaccinated against COVID-19, we conducted a seroprevalence
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Establishment of Safety Monitoring System for Vaccines Not Included in the National Immunization Program in Korea. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-05 Eliel Nham, Jin Gu Yoon, Min Joo Choi, Yu Bin Seo, Jacob Lee, Won Suk Choi, Hakjun Hyun, Hye Seong, Ji Yun Noh, Joon Young Song, Woo Joo Kim, Hee Jin Cheong
In Korea, there are no surveillance programs for vaccines that are not included in the national immunization program (NIP), and vaccine safety monitoring in the adult population is inadequate. This study aimed to establish a safety monitoring system for non-NIP vaccines in adults.
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Validation of the Framingham Diabetes Risk Model Using Community-Based KoGES Data. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-05 Hye Ah Lee, Hyesook Park, Young Sun Hong
An 8-year prediction of the Framingham Diabetes Risk Model (FDRM) was proposed, but the predictor has a gap with current clinical standards. Therefore, we evaluated the validity of the original FDRM in Korean population data, developed a modified FDRM by redefining the predictors based on current knowledge, and evaluated the internal and external validity.
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Guillain-Barré Syndrome After COVID-19 Infection in Korea: A Case Series. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-05 Nayoung Ryoo, Hyoshin Son, Jean Hee Kim, Dae Woong Bae, Jae Young An
Guillain-Barré syndrome (GBS) is an autoimmune-driven condition characterized by acute polyneuropathy, often emerging as a sequel to prior infections or vaccinations. This study presents the first reported cases of GBS emerging after the full recovery from coronavirus disease 2019 (COVID-19) infection in Korea. Despite experiencing mild acute COVID-19 symptoms, these patients faced substantial weakness
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Consensus Statements on the Definition, Classification, and Diagnostic Tests for Tinnitus: A Delphi Study Conducted by the Korean Tinnitus Study Group. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-05 Oak-Sung Choo, Hantai Kim, Seung Jae Lee, So Young Kim, Kyu-Yup Lee, Ho Yun Lee, In Seok Moon, Jae-Hyun Seo, Yoon Chan Rah, Jae-Jun Song, Eui-Cheol Nam, Shi Nae Park, Jae-Jin Song, Hyun Joon Shim
Tinnitus is a bothersome condition associated with various symptoms. However, the mechanisms of tinnitus are still uncertain, and a standardized assessment of the diagnostic criteria for tinnitus is required. We aimed to reach a consensus on diagnosing tinnitus with professional experts by conducting a Delphi study with systematic review of the literature.
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The Risk of Hypertension and Diabetes Mellitus According to Offspring's Birthweight in Women With Normal Body Mass Index: A Nationwide Population-Based Study. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-05 Young Mi Jung, Wonyoung Wi, Kyu-Dong Cho, Su Jung Hong, Ho Yeon Kim, Ki Hoon Ahn, Soon-Cheol Hong, Hai-Joong Kim, Min-Jeong Oh, Geum Joon Cho
Maladaptation to vascular, metabolic, and physiological changes during pregnancy can lead to fetal growth disorders. Moreover, adverse outcomes during pregnancy can further increase the risk of cardiovascular and metabolic diseases in mothers. Delivering a large-for-gestational-age (LGA) baby may indicate a pre-existing metabolic dysfunction, whereas delivering a small-for-gestational-age (SGA) baby
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Early Prediction of Mortality for Septic Patients Visiting Emergency Room Based on Explainable Machine Learning: A Real-World Multicenter Study. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-05 Sang Won Park, Na Young Yeo, Seonguk Kang, Taejun Ha, Tae-Hoon Kim, DooHee Lee, Dowon Kim, Seheon Choi, Minkyu Kim, DongHoon Lee, DoHyeon Kim, Woo Jin Kim, Seung-Joon Lee, Yeon-Jeong Heo, Da Hye Moon, Seon-Sook Han, Yoon Kim, Hyun-Soo Choi, Dong Kyu Oh, Su Yeon Lee, MiHyeon Park, Chae-Man Lim, Jeongwon Heo
Worldwide, sepsis is the leading cause of death in hospitals. If mortality rates in patients with sepsis can be predicted early, medical resources can be allocated efficiently. We constructed machine learning (ML) models to predict the mortality of patients with sepsis in a hospital emergency department.
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Identification of Atrial Fibrillation With Single-Lead Mobile ECG During Normal Sinus Rhythm Using Deep Learning. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-02-05 Jiwoong Kim, Sun Jung Lee, Bonggyun Ko, Myungeun Lee, Young-Shin Lee, Ki Hong Lee
The acquisition of single-lead electrocardiogram (ECG) from mobile devices offers a more practical approach to arrhythmia detection. Using artificial intelligence for atrial fibrillation (AF) identification enhances screening efficiency. However, the potential of single-lead ECG for AF identification during normal sinus rhythm (NSR) remains under-explored. This study introduces a method to identify
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Clinical Features of Mpox Patients in Korea: A Multicenter Retrospective Study. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-29 So Yun Lim, Hyeon Jae Jo, Su-Yeon Lee, Miyoung Ahn, Yeonjae Kim, Jaehyun Jeon, Eu Suk Kim, BumSik Chin, Jae-Phil Choi, Nam Joong Kim
Mpox is a viral illness with a characteristic skin rash caused by the monkeypox virus. In 2022, Mpox spread throughout the world, and an epidemic through domestic transmission started in South Korea in early 2023. This study aimed to summarize the clinical features of Mpox patients in South Korea.
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Spirometric Interpretation and Clinical Relevance According to Different Reference Equations. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-29 Hyun Woo Lee, Jung-Kyu Lee, Yong-Il Hwang, Hyewon Seo, June Hong Ahn, Sung-Ryeol Kim, Hyun Jung Kim, Ki-Suck Jung, Kwang Ha Yoo, Deog Kyeom Kim
Global Lung Function Initiative (GLI)-2012 reference equation is currently suggested for interpretation of spirometry results and a new local reference equation has been developed in South Korea. However, lung function profiles according to the different reference equations and their clinical relevance have not been identified in chronic obstructive pulmonary disease (COPD) patients.
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Risk of Pancreatic Cancer After Acute Pancreatitis: A Retrospective Analysis of the Korean National Sample Cohort. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-29 Sung Hoon Jeong, Kyungduk Hurh, Eun-Cheol Park, Ja-Ho Leigh, Seung Hoon Kim, Sung-In Jang
Acute pancreatitis may increase the risk of pancreatic cancer, although this association remains unclear. Therefore, we aimed to investigate this association.
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The Epidemiology of Hepatitis B Virus Infection in Korea: 15-Year Analysis. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-29 Log Young Kim, Jeong-Ju Yoo, Young Chang, Hoongil Jo, Young Youn Cho, Sangheun Lee, Dong Hyeon Lee, Jae Young Jang
The purpose of this study is to investigate the epidemiological changes in chronic hepatitis B (CHB) and assess the impact of coronavirus disease 2019 (COVID-19) over the past 15 years in a region endemic to hepatitis B virus (HBV).
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Factors Affecting Adherence to National Colorectal Cancer Screening: A 12-Year Longitudinal Study Using Multi-Institutional Pooled Data in Korea. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-29 Dae Sung Kim, Jeeyoung Hong, Kihyun Ryu, Sang Hyuk Lee, Hwanhyi Cho, Jehyeong Yu, Jieun Lee, Jong-Yeup Kim
Consistent uptake of colorectal cancer (CRC) screening is important to reduce the incidence and mortality from advanced-stage CRC and increase the survival rate of the patients. We conducted a longitudinal study to determine the factors affecting CRC screening compliance in Korean adults using individual-level linked data from the Korean National Health and Nutrition Examination Survey, Korean National
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The Risk of COVID-19 and Its Outcomes in Korean Patients With Gout: A Multicenter, Retrospective, Observational Study. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-29 Min Jung Kim, Borim Ryu, Eun-Gee Park, Siyeon Yi, Kwangsoo Kim, Jun Won Park, Kichul Shin
This retrospective cohort study aimed to compare coronavirus disease 2019 (COVID-19)-related clinical outcomes between patients with and without gout. Electronic health record-based data from two centers (Seoul National University Hospital [SNUH] and Boramae Medical Center [BMC]), from January 2021 to April 2022, were mapped to a common data model. Patients with and without gout were matched using
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Prevalence and Burden of Human Adenovirus-Associated Acute Respiratory Illness in the Republic of Korea Military, 2013 to 2022. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-29 Donghoon Kim, Eunyoung Lee, Jungmin Eom, Yeonjae Kim, Soon-Hwan Kwon, Hong Sang Oh, Kyungmin Huh, Hyesook Park, Jaehun Jung, Bomi Park
Human adenovirus (HAdV) is a common cause of acute respiratory disease (ARD) and has raised significant concerns within the Korean military. Here, we conducted a comprehensive epidemiological analysis of HAdV-associated ARD by evaluating its prevalence, clinical outcomes, and prognosis.
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Mid-Term Strategic Plan for the Public Health and Medical Care Cooperation in the Korean Peninsula. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-29 Yun Seop Kim, Jin-Won Noh, Yo Han Lee, Sin Gon Kim
As extensive as the concept of and the resources required for 'Health for Korean Unification' are, and due to the limited access to information on the state of health and medical care in North Korea, discussion on 'Health for Korean Unification' has tended to be intermittent and lacked concrete action plans. In this article, we specifically distinguished areas of cooperation and selected five executable
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Application of the Time Derivative (TD) Method for Early Alert of Influenza Epidemics. J. Korean Med. Sci. (IF 4.5) Pub Date : 2024-01-29 Seul-Ki Kang, Woo-Sik Son, Bryan Inho Kim
In order to minimize the spread of seasonal influenza epidemic to communities worldwide, the Korea Disease Control and Prevention Agency has issued an influenza epidemic alert using the influenza epidemic threshold formula based on the results of the influenza-like illness (ILI) rate. However, unusual changes have occurred in the pattern of respiratory infectious diseases, including seasonal influenza