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Changes in clinical parameters and inflammatory markers after blood culture collection facilitate early identification of positive culture in adult patients with COVID-19 and clinically suspected bloodstream infection J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-17 Nana Li, Long Zhang, Yang Gao, Qiqi Lai, Yujia Tang, Xue Du, Pengfei Chen, Chuangshi Yue, Mingyan Zhao, Kaijiang Yu, Kai Kang
ObjectiveWe explored whether changes in clinical parameters and inflammatory markers can facilitate early identification of positive blood culture in adult patients with COVID-19 and clinically suspected bloodstream infection (BSI).MethodsThis single-center retrospective study enrolled 20 adult patients with COVID-19 admitted to the intensive care unit who underwent blood culture for clinically suspected
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Extranodal Rosai–Dorfman disease manifesting as Sjögren’s syndrome combined with panuveitis and hypertrophic pachymeningitis: a case report and review of literature J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-17 Jing Xu, Meihua Huang, Binsong Dong, Min Jian, Jinyu Chen, Naiyuan Zhang, Chunlian Ou, Yongming Wu, Dongmei Wang
Rosai–Dorfman disease (RDD) is a rare non-Langerhans cell histiocytosis characterized by massive lymphadenopathy and systemic extranodal lesions. We present the case of a 28-year-old woman who presented with recurrent blurred vision in her right eye for 3 months. She developed blindness and atrophy in her left eye a decade prior to presentation. She subsequently developed headache, fever, and impaired
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Delayed flail chest from osteomyelitis and malnutrition that emerged 3 weeks after blunt chest trauma: a case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-17 Jin Bong Ye, Jin Young Lee, Junepill Seok
We present the case of a victim of a motor vehicle accident in his late 60s who suffered from severe torso injuries. He initially presented with abdominal and chest pain, and underwent emergency laparotomy for hemoperitoneum. After surgery, the patient developed pneumonia and septicemia, which were responsive to antibiotics. The patient was treated with mechanical ventilation in the intensive care
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Establishment of animal models and behavioral studies for autism spectrum disorders J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-15 Daiyan Jiao, Yingkai Xu, Fei Tian, Yaqing Zhou, Dong Chen, Yujue Wang
In recent years, the incidence of autism spectrum disorder (ASD) has increased, but the etiology and pathogenesis remain unclear. In this narrative review, we review and systematically summarize the methods used to construct animal models to study ASD and the related behavioral studies based on recent literature. Utilization of various ASD animal models can complement research on the etiology, pathogenesis
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Glycated serum protein is independently associated with progressive infarction in patients with acute ischemic stroke J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-13 Keji Zou, Caixia Wei, Qin Huang, Zubing Xu, Xiaocheng Mao, Hudie Zhang, Chenying Zeng, Lanjiao Zhang, Jing Lin, Yuling Yi, Jinchong Zhang
ObjectiveThis study investigated the relationship between glycated serum protein (GSP) and progressive infarction (PI).MethodsFrom April 2017 to December 2020, we recruited 477 patients within 48 hours after the onset of acute ischemic stroke into this case–control study. Demographic characteristics, clinical information, and laboratory and neuroimaging data were recorded after admission.ResultsPI
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Association of the neutrophil-to-lymphocyte ratio with the occurrence of venous thromboembolism and arterial thrombosis J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-12 Ha Thanh Nguyen, Minh Phuong Vu, Thi Tuyet Mai Nguyen, Tuan Tung Nguyen, Thi Van Oanh Kieu, Hai Yen Duong, Phuong Thao Pham, Thi Hue Hoang
ObjectiveThis study aimed to assess the association of the neutrophil-to-lymphocyte ratio (NLR) with the occurrence of venous thromboembolism (VTE) and arterial thrombosis (AT).MethodsThis was a retrospective cross-sectional study including 585 medical records obtained from all consecutive patients who were suspected of having thrombosis.ResultsThe AT group had a higher neutrophil count and NLR and
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Predictors of cancer-specific survival and overall survival among patients aged ≥60 years with lung adenocarcinoma using the SEER database J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-12 Feiyang Li, Fang Li, Dong Zhao, Haowei Lu
ObjectiveWe developed a simple, rapid predictive model to evaluate the prognosis of older patients with lung adenocarcinoma.MethodsDemographic characteristics and clinical information of patients with lung adenocarcinoma aged ≥60 years were retrospectively analyzed using Surveillance, Epidemiology, and End Results (SEER) data. We built nomograms of overall survival and cancer-specific survival using
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Multiple carcinomas in a woman with HIV infection: a case report and literature review J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-12 John Adi Ashindoitiang, Victor Ikechukwu Carnice Nwagbara, Mba Okpan Ozinko, Theophilus Ipeh Ugbem, Maurice Efana Asuquo
Non-acquired immunodeficiency syndrome-defining cancers (NADCs) are malignancies in persons living with human immunodeficiency virus (PLWHIV) and are not primarily due to the host’s immunodeficiency. There is renewed clinical interest in long-term morbidities in PLWHIV as well as malignancies that occur in this population. We herein describe a 36-year-old woman with a 2-year history of an anal wound
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Intraventricular haemorrhage treated by extra ventricular drainage with catheter mistakenly penetrating the cisterna ambiens: A case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-12 Liansheng Gao, Kaibo Yu, Yanfei Feng, Feng Yan, Cong Qian
Intraventricular haemorrhage (IVH) is a severe and acute type of stroke with a complex pathophysiology and is a therapeutic challenge. This case report described a man in his early 50’s diagnosed with IVH by computed tomography (CT). Although bilateral extraventricular drainage (EVD) was undertaken, a postoperative CT scan showed that while the left catheter was correctly positioned, the right catheter
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Granulomatosis with polyangiitis or its mimic? A case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-12 Tamás Major, Gábor Nagy, Judit Szabó, Huba Mózes, Gabriella Szűcs, Zoltán Szekanecz, Szilvia Szamosi
Differentiation between granulomatosis with polyangiitis (GPA) limited to the upper airways and cocaine-induced midline destructive lesion (CIMDL) may be particularly difficult because of their common histopathologic features and antineutrophil cytoplasmic antibody (ANCA) profiles. We herein present a case involving a young woman with an initial diagnosis of GPA based on upper and lower airway manifestations
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Isolated gastric varices associated with antiphospholipid syndrome and protein S deficiency: a case report and review of the literature J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-11 Xueyan Li, Jiandi Wu, Feifei Fang, Ying Liu, Wewei Jiang, Gangping Li, Jun Song
The mortality rate of gastric varices bleeding can reach 20% within 6 weeks. Isolated gastric varices (IGVs) refer to gastric varices without esophageal varices and typically arise as a common complication of left portal hypertension. Although IGVs commonly form in the setting of splenic vein occlusion, the combination of antiphospholipid syndrome and protein S deficiency leading to splenic vein occlusion
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Use of noninvasive brain stimulation and neurorehabilitation devices to enhance poststroke recovery: review of the current evidence and pitfalls J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-11 Chien-Chih Wang, Tsung-Ming Hu, Yung-Jie Lin, Chien-Lung Chen, Yu-Chuan Hsu, Chung-Lan Kao
Neurorehabilitation devices and technologies are crucial for enhancing stroke recovery. These include noninvasive brain stimulation devices that provide repetitive transcranial magnetic stimulation or transcranial direct current stimulation, which can remodulate an injured brain. Technologies such as robotics, virtual reality, and telerehabilitation are suitable add-ons or complements to physical therapy
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Temporomandibular disorders among Ehlers-Danlos syndromes: a narrative review J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-11 Ole Oelerich, Linda Daume, Negin Yekkalam, Marcel Hanisch, Max C. Menne
This narrative review aims to demonstrate and summarize the complex relationship between Ehlers-Danlos syndromes (EDS) and temporomandibular disorders (TMD) by reviewing the results of observational studies and case reports. EDS are a set of hereditary connective tissue disorders, where generalized joint hypermobility (GJH), especially in the hypermobile subtype (hEDS), is a key symptom. Mutations
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Sildenafil improves hemodynamic changes caused by acute pulmonary embolism by inhibiting Rho kinase activity J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-11 Hui Wang, Wei Li, Yan Yan, Meng-Jie Shi, Feng Hou, Rui-Peng Zhang
ObjectiveThis study examined the effects of sildenafil on acute pulmonary embolism (APE) using a rat model.MethodsSprague–Dawley rats were randomly divided into the sham, pulmonary thromboembolism (PTE), and sildenafil groups. The sham and PTE groups received normal saline once daily via gavage for 14 consecutive days, whereas the sildenafil group received sildenafil (0.5 mg/kg/day) once daily via
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Hepatic portal venous gas initially manifesting as severe shock: a case series J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-11 Anwei Liu, Jiao Shen, Liansheng Long, Xuezhi Shi, Qiang Wen, Zhiguo Pan
Hepatic portal venous gas is often referred to as the “sign of death” because it signifies a very poor prognosis if appropriate treatments are not promptly administered. The etiologies of hepatic portal venous gas are diverse and include severe complex abdominal infections, mesenteric ischemia, diving, and complications of endoscopic surgery, and the clinical manifestations are inconsistent among individual
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An immunocompetent host with blood-disseminated Aspergillus versicolor spondylitis: a case report and literature review J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-10 Shuangxia Dong, Qianding Lin, Xinjian Dai, Zhou Lin
Blood-disseminated Aspergillus spondylitis in immunocompetent individuals is rare. The clinical, imaging, and pathological manifestations of this condition are not specific. Therefore, this disease is prone to misdiagnosis and a missed diagnosis. Systemic antifungal therapy is the main treatment for Aspergillus spondylitis. We report a case of blood-disseminated Aspergillus versicolor spondylitis in
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Portal vein gas is a sign of intestinal necrosis after pesticide poisoning: a case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-10 Huipeng Zhu, Guozhong Chen, Shiyi Liu, Keyan Hong, Huajun Wang
Portal vein gas accumulation and intestinal pneumatosis are uncommon signs indicating a high mortality risk in cases of intestinal ischemic necrosis. However, the widespread use of computed tomography has led to an increase in detection of benign lesions. We report a case of portal vein gas accumulation resulting from organophosphorus pesticide poisoning. A male patient was brought to the hospital
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Characterization and prevention of flame burns caused by electric bicycle battery chargers: results from a 7-year experience J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-08 Xiqiao Wang, Ming Tian, Liqiang Zheng, Liang Qiao, Yan Liu, Bo Yuan
ObjectiveWith the recent exponential increase in express deliveries across China, the number of patients with flame burns caused by electric bicycle battery chargers (BEBBC) has markedly increased in burn units. In this study, we aimed to characterize BEBBC to systematically explore measures to prevent their occurrence.MethodsWe performed a retrospective chart review of patients with flame burns who
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COVID-19-induced acute loss of consciousness in Marchiafava–Bignami disease: a case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-08 Jie Tian, Hai-li Wang, Shuang-jie Li, Chang-he Shi
Among the various manifestations of COVID-19, the neurological implications of SARS-CoV-2 infection are of significant concern. Marchiafava–Bignami disease (MBD), a neurodegenerative disorder, exhibits a clinical spectrum ranging from mild progressive dementia in its chronic form to states of acute coma and varied mortality rates. Acute MBD primarily occurs in chronic alcoholics and malnourished individuals
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Improving accuracy of vascular access quality classification in hemodialysis patients using deep learning with K highest score feature selection J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-04 Sarayut Julkaew, Thakerng Wongsirichot, Kasikrit Damkliang, Pornpen Sangthawan
ObjectiveTo develop and evaluate a novel feature selection technique, using photoplethysmography (PPG) sensors, for enhancing the performance of deep learning models in classifying vascular access quality in hemodialysis patients.MethodsThis cross-sectional study involved creating a novel feature selection method based on SelectKBest principles, specifically designed to optimize deep learning models
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Application of radiomics in ischemic stroke J. Int. Med. Res. (IF 1.6) Pub Date : 2024-04-03 Jie Yang, Huabo Cai, Ning Liu, Jiajie Huang, Yun Pan, Bo Zhang, Minfeng Tong, Zhongheng Zhang
In recent years, radiomics has emerged as a novel research methodology that plays a crucial role in the diagnosis and treatment of ischemic stroke. By integrating multimodal medical imaging techniques such as computed tomography and magnetic resonance imaging, radiomics offers in-depth insights into aspects such as the extent of brain tissue damage and hemodynamics. These data help physicians to accurately
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Hydrogen treatment reduces electroencephalographic activity and neuronal death in rats with refractory status epilepticus by inhibiting membrane NR2B phosphorylation and oxidative stress J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-28 Ruihua Jia, Gemin Zhu, Rui Zhao, Tian Li, Wen Jiang, Xiaoli Cui
ObjectiveTo investigate the effects of hydrogen therapy on epileptic seizures in rats with refractory status epilepticus and the underlying mechanisms.MethodsStatus epilepticus was induced using pilocarpine. The effects of hydrogen treatment on epilepsy severity in model rats were then monitored using Racine scores and electroencephalography (EEG), followed by western blot of plasma membrane N-methyl-D-aspartate
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Genetic predisposition to early mycosis fungoides: investigating genetic polymorphisms in tissue-resident memory T-cell genes J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-28 Nour Almaani, Fatima Farhan, Salsabiela Bani Hamad, Eman A Abuhawileh, Lana Koubaitary, Mamoun Ahram, Tariq N Aladily
ObjectivesMycosis fungoides (MF) is the most common cutaneous T-cell lymphoma; it arises from tissue-resident memory T-cells (TRM). In the present study, we investigated potential functional genetic variations that may predispose MF development.MethodsA case–control study was conducted using whole-exome sequencing, with a focus on genes that are essential to TRM function.ResultsWe included 21 patients
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Butylphthalide combined with donepezil for the treatment of vascular dementia: a meta-analysis J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-28 Puqing Liu, Xiangjuan Liu, Jingwen Chen, Yi Zhang, Jun Chen, Lei Yu, Zhangxuan Shou
ObjectiveTo systematically evaluate the efficacy and safety of butylphthalide combined with donepezil versus butylphthalide monotherapy for the treatment of vascular dementia.MethodsRandomized controlled trials were searched in electronic databases, including PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, Chinese Science and Technology Periodical Database (VIP), Wan
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Should atelectasis be considered a pulmonary complication and indicator of poor prognosis in cystic fibrosis? J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-28 María Martínez Redondo, Carlos Carpio Segura, Ester Zamarrón De Lucas, Rodolfo Álvarez-Sala Walther, Concepción Prados Sánchez
ObjectiveThis study examined whether bronchoscopy leads to clinicoradiological improvement in cystic fibrosis (CF) and the predictive factors. The study also investigated whether pulmonary atelectasis is a poor prognostic factor in CF.MethodsThis multicenter, case–control, observational, retrospective study included two groups of patients with CF: a case group (patients with persistent atelectasis
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Myelin oligodendrocyte glycoprotein antibody-associated disease with clinical presentation as multiple episodes of isolated meningeal involvement: a case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-28 Xiaojie Wei, Chentong Zhao, Daqing Wang, Jingzhe Han
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) constitutes a group of autoimmune neuroinflammatory conditions that are characterized by positive serum MOG-immunoglobulin G antibodies. The relationship between MOGAD and immune factors remains unclear. Herein, we report a man in his early 30s who initially presented symptoms of headache and low-grade fever persisting for 20 days
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Synovial sarcoma of the viscera (lung and jejunum): a case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-27 Jixin He, Jiwei Wang, Lina Yang, Kai Wang, Maijian Wang, Jianguo Li
We report the case of a woman nearing 70 years old who was admitted to the hospital with a complaint of “epigastric distension for 1 month”. Her main signs and symptoms were progressive abdominal distension and occasional abdominal pain. Computed tomography suggested an abdominal mass. She had a surgical history of synovial sarcoma (SS) of the lungs. After admission, she was diagnosed with jejunal
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Relationship between SIRI and android and gynoid fat related to obesity and cardiovascular risk: a cross-sectional study of NHANES 2017–2018 J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-27 Xuanchun Zhang
ObjectiveInflammation has a crucial role in several metabolic diseases, such as obesity. The author aimed to investigate the relationship between the system inflammation response index (SIRI) and android fat composition and distribution.MethodsData for individuals aged 8–59 years, SIRI, android percent fat, and android-to-gynoid ratio from the 2017 to 2018 National Health and Nutrition Examination
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Learning curve of ultrasound-guided percutaneous nephrolithotripsy in the treatment of complex renal calculi J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-27 Zhaoxiang Lu, Wentie Yang, Wei He
ObjectiveThis study was performed to investigate the learning curve of ultrasound-guided percutaneous nephrolithotripsy (PCNL) for the treatment of complex renal calculi.MethodsSeventy-two patients with complex renal stones who underwent ultrasound-guided PCNL by the same operator from November 2016 to September 2020 were retrospectively analyzed. The learning curve of PCNL for complex renal stones
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Unstable Vancouver B1 periprosthetic femoral fracture fixation: A biomechanical comparison between a novel C-shaped memory alloy implant and cerclage wiring J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-27 Seog-Hyun Oh, Yu-Sung Suh, Emmanuel Eghan-Acquah, Kollerov Mikhail Yurevich, Sung-Hun Won, Min Jung Baek, Sung-Jae Lee, Sung-Woo Choi
BackgroundTo compare the biomechanical stability of a novel, C-shaped nickel–titanium shape memory alloy (SMA) implant (C-clip) with traditional cerclage wiring in the fixation of a Vancouver B1 (VB1) periprosthetic femoral fracture (PFF).MethodsIn total, 18 synthetic femoral fracture models were constructed to obtain unstable VB1 fracture with an oblique fracture line 8 cm below the lesser trochanter
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Efficacy and safety of caspofungin for the treatment of invasive pulmonary aspergillosis in patients with chronic obstructive pulmonary disease J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-26 Shaoqiang Li, Zhengtu Li, Penglei Wang, Yangqing Zhan, Jiaxing Xie, Feng Ye
ObjectivesWe assessed the efficacy of a 3-week primary or salvage caspofungin regimen in patients with chronic obstructive pulmonary disease (COPD) and concomitant proven or suspected invasive pulmonary aspergillosis (IPA).MethodsForty-four patients were treated with an initial loading caspofungin dose of 70 mg, followed by a daily dose of 50 mg for 20 days. The main efficacy endpoint was clinical
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A case of mild partial androgen insensitivity syndrome in a juvenile boy J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-26 Fen Wang, Shiying Shao, Wentao He, Shuhong Hu
Androgen insensitivity syndrome (AIS) is a rare disorder with X-linked recessive inheritance in 46 XY patients. The clinical manifestations vary between patients, especially regarding external genitalia development. Herein, the case of AIS in a 13-year-old male, who was born with hypospadias and presented to the hospital with gynaecomastia that had developed from 8 years of age, is reported. No micropenis
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Hypomethylation of the LncRNA H19 promoter accelerates osteogenic differentiation of vascular smooth muscle cells by activating the Erk1/2 pathways J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-26 Taoxia Wang, Meijuan Cheng, Jingjing Jin, Yaling Bai, Dongxue Zhang, Shenglei Zhang, Jinsheng Xu
ObjectiveVascular calcification is a common chronic kidney disease complication. This study aimed to investigate the function of long non-coding RNA (LncRNA) H19 in vascular calcification to explore new therapeutic strategies.MethodsWe induced osteogenic differentiation and calcification of vascular smooth muscle cells (VSMCs) using β-glycerophosphate. Then, we detected the LncRNA H19 promoter methylation
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Drugs associated with a risk of supraventricular tachycardia: analysis using the OpenVigil database J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-26 Weihong Chen, Shaobin Li, Dongqin Huang, Yuchao Su
ObjectiveThe OpenVigil database can be used to assess medications that may cause supraventricular tachycardia (SVT) and to produce a reference for their safe use in clinical settings.MethodsWe analyzed first-quarter data from 2004 to 2023, obtained by searching the OpenVigil database using the keyword “supraventricular tachycardia.” Trade names and generic names were obtained by querying the RxNav
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Albumin and C-reactive protein as diagnostic markers for neonatal sepsis: a retrospective study J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-26 Wei Yin, ChengChao Fang, Xiaoping Fan, YanLin Chen
ObjectiveTo assess the applicability of albumin (ALB) and C-reactive protein (CRP) concentrations in the diagnosis of sepsis in neonates on the day of admission, and to help with early identification and intervention in the development of sepsis.MethodsThis retrospective study included all neonates who were admitted to the neonatal intensive care unit from January 2020 to June 2023. We studied 160
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Enhancing predictions with a stacking ensemble model for ICU mortality risk in patients with sepsis-associated encephalopathy J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-26 Xuhui Liu, Hao Niu, Jiahua Peng
ObjectiveWe identified predictive factors and developed a novel machine learning (ML) model for predicting mortality risk in patients with sepsis-associated encephalopathy (SAE).MethodsIn this retrospective cohort study, data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) and eICU Collaborative Research Database were used for model development and external validation. The primary
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Efficacy of laser obliteration with limited excision of pilonidal sinus J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-26 Erekle Gratiashvili, Lali Akhmeteli, Teimuraz Ivanishvili, Salome Kobadze, Nodar Giorgadze
ObjectiveThis study was performed to compare the effectiveness of laser obliteration with limited excision (LOLE) versus wide excision (WE) of the pilonidal sinus.MethodsA prospective, cross-sectional observational study of 152 patients with chronic pilonidal sinus disease was performed from September 2019 to September 2022. Of the 152 patients, 76 underwent LOLE and 76 underwent WE. The main evaluation
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Construction of an oxidative stress-associated genes signature in breast cancer by machine learning algorithms J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-23 Daojun Hu, Bing Qin, Li Zhang, Hanli Bu
ObjectiveTo construct a prognostic model of a breast cancer-related oxidative stress-related gene (OSRG) signature using machine learning algorithms.MethodsThe OSRGs of breast cancer were constructed by least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression analysis. The Cancer Genome Atlas (TCGA) was used to analyse the gene expression and prognostic value. The Human
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Etiological characteristics of acute respiratory infections during the SARS-CoV-2 epidemic in Guizhou Province, China J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-23 Xue Fu, Ming-Wang Long, Zhen-Xuan Ye, Hong-Mei Li, Hai-Yan Zhang, Yu He, Bi-Wei Yang, Bo Xu, Hua Zhang
ObjectiveAcute respiratory infections are a major global public health concern. However, there are few epidemiological studies investigating pathogens associated with respiratory tract infections in Guizhou Province, China.MethodsWe collected 17,850 blood samples from Guizhou Provincial People’s Hospital between November 2018 and May 2023 to investigate the epidemiological characteristics of respiratory
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The pathological roles and potential mechanisms of vascular endothelial growth factor receptor-3 in gastric cancer J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-22 Xiu-Feng Li, Xiu-Juan Zhang, Fu-Rong Hao, Xiao-Tong Dong, Guo-Dong Xu, Yun-Xiang Zhang
ObjectiveTo investigate the roles and underlying mechanisms of vascular endothelial growth factor receptor-3 (VEGFR-3) in gastric cancer (GC).MethodsVEGFR-3 gene expression profiles in human gastric adenocarcinoma (GAC) tissues were analysed using The Cancer Genome Atlas database. Human GC cell lines and were used for in vitro studies. Mouse models of GC and distant metastasis were used for in vivo
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Clinical presentation and management outcome of pediatric intussusception at Wolaita Sodo University Comprehensive Specialized Hospital: a retrospective cross-sectional study J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-22 Yohannes Zewde, Tamrat Bugie, Abel Daniel, Awoke Wodajo, Mengistu Meskele
ObjectiveTo assess the pattern of clinical presentations and factors associated with the management outcome of pediatric intussusception among children treated at Wolaita Sodo University Comprehensive Specialized Hospital, Ethiopia.MethodsThis retrospective cross-sectional study included the medical records of 103 children treated for intussusception from 2018 to 2020. The data collected were analyzed
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Bone involvement in the early stages of Parkinson’s disease: a case–control study J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-22 Sara Liguori, Antimo Moretti, Marco Paoletta, Fiorinda Gargiulo, Giuseppe Barra, Francesca Gimigliano, Giovanni Iolascon
ObjectiveTo evaluate the qualitative and quantitative alterations of bone tissue in patients with early-stage Parkinson’s disease (PD) and to measure the associations between bone mineral density (BMD), trabecular bone score (TBS) and physical performance.MethodsThis case–control study enrolled patients with early-stage PD and age-matched controls. BMDs for the left femoral neck (L-FN) and lumbar spine
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Association of iron overload with infectious complications in liver transplant recipients: a systematic review and meta-analysis J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-22 Jingpo Zhang, Bingzheng Yan, Xin Shi
ObjectiveThis study was performed to examine the possible association of iron overload with infectious complications and survival among liver transplant recipients.MethodsWe conducted a systematic review and meta-analysis of studies published in the PubMed, Embase, Web of Science, and Cochrane Library databases up to September 2022. Hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted
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Systemic inflammation response index as a prognostic factor for patients with sepsis-associated acute kidney injury: a retrospective observational study J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-22 Jia Tang, Zhenguang Zhong, Muyesai Nijiati, Changdong Wu
ObjectiveTo assess the association between the systemic inflammation response index (SIRI) and the prognosis in patients with sepsis-associated acute kidney injury (SA-AKI).MethodsIn this observational study, adult patients with SA-AKI were categorized into three groups based on SIRI tertiles. Survival outcomes were compared across the three groups using Kaplan–Meier survival curves. Various Cox proportional
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Percutaneous placement of a retrievable fully covered metal stent with anchoring flaps for the treatment of biliary anastomotic stricture following LDLT J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-21 Joonho Hur, Woosun Choi, Sang Lim Choi, Suk-Won Suh
To investigate the outcomes following percutaneous placement of a retrievable fully covered self-expanding metal stent (fcSEMS) with anchoring flaps at proximal and distal ends for the treatment of biliary anastomotic strictures following living-donor liver transplantation (LDLT). We retrospectively reviewed the medical records of nine patients who underwent this procedure at our centre between April
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Chemotherapy-induced pneumatosis intestinalis followed by hepatic portal venous gas. A case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-21 WenJun Pan, Shuai Xiang, Junhao Zhang, Yuan Gao, Shanglong Liu
Pneumatosis intestinalis (PI) is a rare disease, and there are many theories about its pathogenesis. Hepatic portal venous gas (HPVG), is thought to occur secondary to intramural intestinal gas emboli migrating through the portal venous system via the mesenteric veins. PI accompanied by HPVG is usually a sign of bowel ischaemia and is associated with a high mortality rate. We report here, a patient
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Reduced cerebral blood flow and cognitive dysfunction following isolated cerebellar infarction: two case reports J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-21 Qi Liu, Yingkui Zhang, Chang Liu, Yu Chen, Yumei Zhang
Cognitive impairment in focal cerebellar disorders has been widely recognized and is described as cerebellar cognitive affective syndrome (CCAS). However, the relationship between CCAS and crossed cerebello-cerebral diaschisis (CCD) has rarely been discussed. The present report describes the uncommon phenomenon of CCD in two cases with isolated cerebellar infarction, and discuss its contribution to
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Expression and clinical role of PRDX6 in lung adenocarcinoma J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-20 Zixin Chen, Junjun Lin, Huifang Wang, Jing Wang, Zhou Zhang
ObjectiveTo explore the levels of expression and clinical role of peroxiredoxin 6 ( PRDX6) in lung adenocarcinoma.MethodsThis retrospective study used a series of bioinformatics methods to detect the levels of expression of and mutations in the PRDX6 gene in a range of cancers and lung adenocarcinoma. Immunohistochemistry was used to verify the levels of expression of PRDX6 protein in samples of lung
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Predictors for anaemia, blood transfusion and outcome in plastic surgery patients J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-20 Ioana Țichil, Teodora Țichil, Ionuț Stefan Haplea, Ciprian Ionuț Tomuleasa, Lucian Fodor, Ileana Mitre
ObjectiveIn patients undergoing plastic surgery, to identify specific risk factors for anaemia and use of blood products, and assess their impact on patient outcome.MethodFor this retrospective study, data were analysed from patients who attended the Plastic Surgery Department at our hospital over a three-year period (2018 to 2020). Adult patients who presented with traumatic injuries, oncologic patients
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Comparison between prefabricated ankle–foot orthoses, Dyna Ankle and UD Flex, in patients with hemiplegia J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-19 Su Ji Lee, Tae Yong Kim, Kyung Min Kim, Sung-Rae Cho
ObjectiveTo compare the kinematic effects of two widely-used prefabricated ankle–foot orthoses (AFOs), the Dyna Ankle (DA) and UD Flex (UD), on the gait cycle of patients with hemiplegia due to cerebral palsy or acquired brain injury.MethodsThis was a retrospective cohort study involving 29 patients. Gait analysis results were assessed under three conditions: barefoot, with the DA, and with the UD
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Onset of acute severe autoimmune hepatitis after severe acute respiratory syndrome coronavirus 2 infection: a case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-19 Yi-Jun Zhou, Qiao-Fei Jin, Chen Wang, Xiao-Jing Zhang, Hong Liu, Jianfeng Bao
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can trigger autoimmune inflammation in the liver, leading to acute autoimmune hepatitis (AIH). We herein report a case involving a 39-year-old woman with a 23-day history of yellow skin and urine. Using the revised original scoring system of the International AIH Group, we definitively diagnosed the patient with acute severe AIH
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Persistent hypernatremia secondary to adipsic central diabetes insipidus in a patient with herpes-induced meningoencephalitis and COVID-19 infection: a case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-19 Faten Cherchir, Ibtissem Oueslati, Salma Salhi, Asma Ben Hamida, Meriem Yazidi, Melika Chihaoui
Central diabetes insipidus (CDI) typically manifests as a polyuria–polydipsia syndrome, in which normonatremia is generally maintained through the polydipsia. A 53-year-old woman presented with diabetic ketosis and hyperosmolar hyperglycemic syndrome. Her medical history included herpes meningoencephalitis, which was associated with confusion and amnesia. On physical examination, she was apyretic,
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Spindle cell embryonal rhabdomyosarcoma of the prostate in an adult patient: a case report and review of the literature J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-19 Hanwen Luo, Xiangtao Weng, Zibin Zhong, Xiongwei Shan, Wenli Lin, Siyi Li, Chiming Gu
Rhabdomyosarcoma of the prostate is a rare mesenchymal tumor that originates from undifferentiated mesenchymal cells. Spindle cell rhabdomyosarcoma is a variant of embryonal rhabdomyosarcoma. The vast majority of these two pathological types occur in children, with only a few adult cases reported to date, and both are associated with poor clinical outcomes. We herein report a case involving a man in
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Value of multiplanar reconstruction in multi-slice computed tomography for the detection of foreign body in the pulmonary artery: a case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-18 Qinxiang Mao, Zheng Lv, Qiuli Han, Wei Zhang
Multi-slice computed tomography (MSCT) is the primary method for the detection and visualization of foreign bodies in the pulmonary artery because it provides high sensitivity and accuracy. It is very difficult to diagnose a patient with a non-iatrogenic pulmonary artery foreign body who does not have a history of a penetrating trauma. This case report describes a 36-year-old male that presented with
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Novel percutaneous technique for creation of porcine model of tricuspid regurgitation via two routes J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-18 Ji Soo Oh, Ga Yun Kim, Seok Hyun Kim, Sang Hyun Lee, Yong Hyun Park, June Hong Kim, Min Ku Chon
ObjectiveTo develop an experimental porcine model of tricuspid regurgitation using two induction routes: the inferior vena cava and superior vena cava.MethodsTricuspid regurgitation was generated using the loop wire cutting method. The tricuspid regurgitation jet direction was controlled by accessing the valve through the inferior (n = 7) or superior (n = 6) vena cava. The occurrence, direction, and
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Transient changes in the ST-T waveform mimicking myocardial infarction in a child with near-drowning: a case report J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-18 Jianmin Zhang, Haitao Lv, Xue Jiang, Yunjia Tang, Miao Hou
Drowning is a common cause of childhood morbidity and mortality worldwide. Anoxia, hypothermia, and metabolic acidosis are mainly responsible for this morbidity. Drowning may lead to multiple organ damage, especially cardiac damage, in cases in which severe hypothermia and hypoxemia occur. We report a case of a 4-year-old girl who was admitted to our hospital’s Emergency Department because of drowning
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Primary adrenal epithelioid sarcoma (proximal type): a case report and literature review J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-18 Daocheng Fang, Hui Li, Yuanyuan Hu
Primary adrenal epithelioid sarcoma is a rare lesion of the adrenal gland, and only seven cases have been reported in the domestic and international literature to date. We herein report a case involving a 65-year-old man with primary adrenal epithelioid sarcoma. After being admitted to the hospital with an adrenal mass found on physical examination, the patient underwent laparoscopic right adrenalectomy
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Case report of parapneumonic effusion and mesothelial subdiaphragmatic cyst: relationship or coincidence? J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-18 Mohamad Hammoud, Carl Ammoury, Charbel Iskandar, Eliane Aoun, Reem Eid, Edouard Sayad
Parapneumonic pleural effusions are common in patients with pneumonia. When colonized by pathogenic bacteria or other microorganisms, these effusions can progress to empyema. Additionally, empyema formation may result in extension of the infection into the infradiaphragmatic region, further complicating the clinical scenario. Many subphrenic collections are found to be mesothelial cysts, which are
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Light chain deposition disease presenting with gastrointestinal disorder as primary manifestation: report of two cases and literature review J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-15 Chenxiang Wei, Min Wang, Jiamin Li, Jiajun Su, Jing Huang, Sunwing Tong, Dongye Yang
Light chain deposition disease (LCDD) is an under-recognized condition characterized by deposition of abnormal monoclonal light chains in tissues, leading to organ dysfunction. LCDD involving the gastrointestinal tract is very uncommon, and its diagnosis is challenging. We herein report two cases of LCDD that manifested as inflammatory bowel disease-like symptoms and protein-losing gastroenteropathy
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Knowledge and awareness of early gastrointestinal cancer screening in Sunan Yugur Autonomous County in Gansu, China J. Int. Med. Res. (IF 1.6) Pub Date : 2024-03-14 Caihong Wang, Yumei Niu
ObjectiveWe aimed to assess the level of knowledge and awareness regarding the need for screening of early gastrointestinal cancer among residents of Sunan Yugur Autonomous County in China.MethodsIn this cross-sectional study, we conducted a survey among permanent residents of Sunan Yugur Autonomous County from January 2020 to January 2023 using a questionnaire to obtain data on knowledge regarding