样式: 排序: IF: - GO 导出 标记为已读
-
Intravenous infusion of dexmedetomidine during the surgery to prevent postoperative delirium and postoperative cognitive dysfunction undergoing non-cardiac surgery: a meta-analysis of randomized controlled trials Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-18 Di Wang, Zhi Liu, Wenhui Zhang, Guo Zu, He Tao, Congjie Bi
Dexmedetomidine plays a pivotal role in mitigating postoperative delirium and cognitive dysfunction while enhancing the overall quality of life among surgical patients. Nevertheless, the influence of dexmedetomidine on such complications in various anaesthesia techniques remains inadequately explored. As such, in the present study, a meta-analysis was conducted to comprehensively evaluate its effects
-
HE4-based nomogram for predicting overall survival in patients with idiopathic pulmonary fibrosis: construction and validation Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-16 Mi Tian, Xiaohui Zhu, Lijun Ren, Xuan Zhou, Lina GU, Kaifang Meng, Yaqiong Tian, Hourong Cai, Xiaoqin Liu, Jingjing Ding
Idiopathic pulmonary fibrosis (IPF) is a life-threatening interstitial lung disease. Identifying biomarkers for early diagnosis is of great clinical importance. The epididymis protein 4 (HE4) is important in the process of inflammation and fibrosis in the epididymis. Its prognostic value in IPF, however, has not been studied. The mRNA and protein levels of HE4 were used to determine the prognostic
-
Dyslipidemia and associated factors among adult cardiac patients: a hospital-based comparative cross-sectional study Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-15 Alemayehu Abera, Abebaw Worede, Agete Tadewos Hirigo, Rahel Alemayehu, Sintayehu Ambachew
Atherosclerotic vascular diseases are a leading global cause of morbidity and mortality. Dyslipidemia, a major modifiable risk factor for cardiovascular disease, remains poorly understood among adult cardiac patients in in the study area. This study aims to determine the prevalence of dyslipidemia and identify associated factors in this population. Hospital-based comparative cross-sectional study was
-
Multi-omics and immunogenomics analysis revealed PFKFB3 as a targetable hallmark and mediates sunitinib resistance in papillary renal cell carcinoma: in silico study with laboratory verification Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-15 Zhongwen Lu, Yongsheng Pan, Songbo Wang, Jiajin Wu, Chenkui Miao, Zengjun Wang
Glycolysis-related metabolic reprogramming is a central hallmark of human cancers, especially in renal cell carcinoma. However, the regulatory function of glycolytic signature in papillary RCC has not been well elucidated. In the present study, the glycolysis-immune predictive signature was constructed and validated using WGCNA, glycolysis-immune clustering analysis. PPI network of DEGs was constructed
-
Effects of ankle–foot orthoses on gait parameters in post-stroke patients with different Brunnstrom stages of the lower limb: a single-center crossover trial Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-15 Fangchao Wu, Zhe Meng, Kezhen Yang, Jianhua Li
Ankle-foot orthoses (AFO) can improve gait posture and walking ability in post-stroke patients. However, the effect of AFO on gait parameters in post-stroke patients according to the Brunnstrom stage of stroke recovery of the lower limbs remains unclear. The study aimed to investigate whether stroke patients with different Brunnstrom stages benefit from wearing AFO. Twenty-five post-stroke participants
-
Exploring the immune-inflammatory mechanism of Maxing Shigan Decoction in treating influenza virus A-induced pneumonia based on an integrated strategy of single-cell transcriptomics and systems biology Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-15 Shiying Zhang, Bei Li, Liuting Zeng, Kailin Yang, Junyao Jiang, Fangguo Lu, Ling Li, Weiqing Li
Influenza is an acute respiratory infection caused by influenza virus. Maxing Shigan Decoction (MXSGD) is a commonly used traditional Chinese medicine prescription for the prevention and treatment of influenza. However, its mechanism remains unclear. The mice model of influenza A virus pneumonia was established by nasal inoculation. After 3 days of intervention, the lung index was calculated, and the
-
Disordered GPR43/NLRP3 expression in peripheral leukocytes of patients with atrial fibrillation is associated with intestinal short chain fatty acids levels Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-15 Chen Fang, Kun Zuo, Zheng Liu, Li Xu, Xinchun Yang
Atrial fibrillation (AF) is associated with circulating inflammation. Short-chain fatty acids (SCFAs) derived from gut microbiota (GM) regulate leukocyte function and inhibit the release of inflammatory cytokines, which are partly mediated by the G-protein-coupled receptor 43 (GPR43) signaling. This study aimed to investigate the expression of GPR43/NOD-like receptors family pyrin domain containing
-
Replication study identified EFEMP1 association with varicose vein predisposition among Indians Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-12 Rohit Mehra, Vikram Patra, Rishi Dhillan, Anuka Sharma, Sonal Kashyap, Garima Rastogi, Love Gupta, Reena Singh, Chirag Chopra, Varun Sharma
Varicose vein is a chronic condition that affects the lower extremities of the human body. Several factors have been implicated in the development of this disease, viz age, gender, weight, height and prolonged standing. Recently, genome-wide studies have identified genetic biomarkers that are associated with varicose veins in different ethnic groups. Such genetic studies are lacking in South Asians
-
Functional analysis and validation of oncodrive gene AP3S1 in ovarian cancer through filtering of mutation data from whole-exome sequencing Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-12 Deshui Kong, Yu Wu, Qiyu Liu, Cuiyu Huang, Tongxia Wang, Zongyao Huang, Yan Gao, Yuan Li, Hongyan Guo
High-grade serous ovarian carcinoma (HGSOC) is the most aggressive and prevalent subtype of ovarian cancer and accounts for a significant portion of ovarian cancer-related deaths worldwide. Despite advancements in cancer treatment, the overall survival rate for HGSOC patients remains low, thus highlighting the urgent need for a deeper understanding of the molecular mechanisms driving tumorigenesis
-
Photodynamic therapy upregulates expression of HIF-1α and PD-L1 in related pathways and its clinical relevance in non-small-cell lung cancer Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-12 Wen Sun, Yuan Cheng, Xiaoyu Ma, Zhou Jin, Qi Zhang, Guangfa Wang
Photodynamic therapy (PDT) is a promising interventional treatment approach that contributes to antitumor immunity. It has been reported that PDT can enhance the effectiveness of immune checkpoint inhibitors (ICIs), but its mechanism is yet unclear. Herein, we implemented bioinformatics analysis to detect common pathways and potential biomarkers in non-small cell lung cancer (NSCLC), PDT, and NSCLC
-
Associations between Life’s Essential 8 and post-stroke depression and all-cause mortality among US adults Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-12 Ruicong Ma, Junting Song, Yanchun Ding
Depression is the common mental disease after stroke. Our objective was to investigate the correlation of Life’s Essential 8 (LE8), the recently updated evaluation of cardiovascular health, with the occurrence of post-stroke depression (PSD) and all-cause mortality among United States (US) adults. Participants with stroke were chosen from the National Health and Nutrition Examination Survey (NHANES)
-
Tyrosine hydroxylase inhibits HCC progression by downregulating TGFβ/Smad signaling Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-12 Guoqian Liu, Mengwei Li, Zimei Zeng, Qi Fan, Xinxin Ren, Zhexin Wang, Yaoqi Sun, Yulin He, Lunquan Sun, Yuezhen Deng, Shupeng Liu, Chenxi Zhong, Jie Gao
The alteration of metabolic processes has been found to have significant impacts on the development of hepatocellular carcinoma (HCC). Nevertheless, the effects of dysfunction of tyrosine metabolism on the development of HCC remains to be discovered. This research demonstrated that tyrosine hydroxylase (TH), which responsible for the initial and limiting step in the bio-generation of the neuro-transmitters
-
Genetically predicted dietary macronutrient intakes and atrial fibrillation risk: a Mendelian randomization study Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-12 Zhuoya Zhang, Jiale Zhang, Haoyang Jiao, Wei Tian, Xu Zhai
Previous observational investigations have indicated a potential association between relative dietary macronutrient intakes and atrial fibrillation and flutter (AF) risk. In this study, we employed Mendelian Randomization (MR) to evaluate the presence of causality and to elucidate the specific causal relationship. We employed six, five, and three single nucleotide polymorphisms (SNPs) as instrumental
-
Circ-10720 as a ceRNA adsorbs microRNA-1238 and modulates ZEB2 to boost NSCLC development by activating EMT Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-12 Wei Zhang, Ping Xiao, Bin Liu, Yan Zhang
Circular RNAs (circRNAs) are critical regulators in the progression of tumors. This experimental design aimed to explore the mechanism of circ-10720 in non-small cell lung cancer (NSCLC). We used RT-qPCR to measure circ-10720 expression in clinical samples and analyzed its relationship with the clinicopathological characteristics of NSCLC patients. The expression levels of microRNA-1238 (miR-1238)
-
Time trajectories and within-subject correlations of matrix metalloproteinases 3, 8, 9, 10, 12, and 13 serum levels and their ability to predict mortality in polytraumatized patients: a pilot study Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-10 Lukas L. Negrin, Greta L. Carlin, Robin Ristl, Stefan Hajdu
Managing polytrauma victims poses a significant challenge to clinicians since applying the same therapy to patients with similar injury patterns may result in different outcomes. Using serum biomarkers hopefully allows for treating each multiple injured in the best possible individual way. Since matrix metalloproteinases (MMPs) play pivotal roles in various physiological processes, they might be a
-
Targeting ferroptosis for leukemia therapy: exploring novel strategies from its mechanisms and role in leukemia based on nanotechnology Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-09 Muhammad Hossein Ashoub, Razieh Razavi, Kamran Heydaryan, Masoud Salavati-Niasari, Mahnaz Amiri
The latest findings in iron metabolism and the newly uncovered process of ferroptosis have paved the way for new potential strategies in anti-leukemia treatments. In the current project, we reviewed and summarized the current role of nanomedicine in the treatment and diagnosis of leukemia through a comparison made between traditional approaches applied in the treatment and diagnosis of leukemia via
-
Immunoglobulins in COVID-19 pneumonia: from the acute phase to the recovery phase Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-06 Joaquim Peraire, Graciano García-Pardo, Silvia Chafino, Alba Sánchez, Maryluz Botero-Gallego, Montserrat Olona, Sonia Espineira, Laia Reverté, Vasso Skouridou, Óscar M. Peiró, Fréderic Gómez-Bertomeu, Francesc Vidal, Ciara K. O’ Sullivan, Anna Rull
COVID-19 pneumonia causes hyperinflammatory response that culminates in acute respiratory syndrome (ARDS) related to increased multiorgan dysfunction and mortality risk. Antiviral-neutralizing immunoglobulins production reflect the host humoral status and illness severity, and thus, immunoglobulin (Ig) circulating levels could be evidence of COVID-19 prognosis. The relationship among circulating immunoglobulins
-
Lung ultrasound and procalcitonin, improving antibiotic management and avoiding radiation exposure in pediatric critical patients with bacterial pneumonia: a randomized clinical trial Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-06 Carmina Guitart, Sara Bobillo-Perez, Javier Rodríguez-Fanjul, José Luis Carrasco, Pedro Brotons, Maria Goretti López-Ramos, Francisco José Cambra, Mònica Balaguer, Iolanda Jordan
Pneumonia is a major public health problem with an impact on morbidity and mortality. Its management still represents a challenge. The aim was to determine whether a new diagnostic algorithm combining lung ultrasound (LUS) and procalcitonin (PCT) improved pneumonia management regarding antibiotic use, radiation exposure, and associated costs, in critically ill pediatric patients with suspected bacterial
-
Identification of fibronectin type III domain containing 3B as a potential prognostic and therapeutic target for pancreatic cancer: a preliminary analysis Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-05 Yizhi Wang, Yang Kong, Qifan Yang, Cheng Zhong, Dongkai Zhou
Fibronectin type III domain containing 3B (FNDC3B), a member of the fibronectin type III domain-containing protein family, has been indicated in various malignancies. However, the precise role of FNDC3B in the progression of pancreatic cancer (PC) still remains to be elucidated. In this study, we integrated data from the National Center for Biotechnology Information, the Cancer Genome Atlas, Genotype-Tissue
-
Establishment of stellate ganglion block in mice Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-04 Qirui Duan, Ying Zhou, Juan Zhi, Quanle Liu, Jin Xu, Dong Yang
There have been no reports on the successful implementation of stellate ganglion block (SGB) in mice. This study aims to investigate a new method for implementing SGB in mice by placing them in a supine position with abducted upper limbs and touching the trachea and sternoclavicular joint with the hand. Fifty BABL/C mice, 8–10 weeks, were selected and randomly divided into four groups: control group
-
Molecular subtyping and the construction of a predictive model of colorectal cancer based on ion channel genes Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-04 Lian-jie Ai, Guo-dong Li, Gang Chen, Zi-quan Sun, Jin-ning Zhang, Ming Liu
Colorectal cancer (CRC) is a highly heterogeneous malignancy with an unfavorable prognosis. The purpose of this study was to address the heterogeneity of CRC by categorizing it into ion channel subtypes, and to develop a predictive modeling based on ion channel genes to predict the survival and immunological states of patients with CRC. The model will provide guidance for personalized immunotherapy
-
Serum PYCARD may become a new diagnostic marker for rheumatoid arthritis patients Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-04 Xue-Li Geng, Yong-Sen Jiang, Chun-Nan Zhao, Ze-Zhi Zhang, Yan-Ling Liu, Pei-Jian Ding
The objective of this investigation is to analyze the levels and clinical relevance of serum PYCARD (Pyrin and CARD domain-containing protein, commonly known as ASC—apoptosis-associated speck-like protein containing a caspase activation and recruitment domain), interleukin-38 (IL-38), and interleukin-6 (IL-6) in individuals afflicted with rheumatoid arthritis (RA). Our study comprised 88 individuals
-
Prediction of malignant esophageal fistula in esophageal cancer using a radiomics-clinical nomogram Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-04 Chao Zhu, Wenju Sun, Cunhai Chen, Qingtao Qiu, Shuai Wang, Yang Song, Xuezhen Ma
Malignant esophageal fistula (MEF), which occurs in 5% to 15% of esophageal cancer (EC) patients, has a poor prognosis. Accurate identification of esophageal cancer patients at high risk of MEF is challenging. The goal of this study was to build and validate a model to predict the occurrence of esophageal fistula in EC patients. This study retrospectively enrolled 122 esophageal cancer patients treated
-
Desmin gene expression is not ubiquitous in all upper airway myofibers and the pattern differs between healthy and sleep apnea subjects Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-03 Per Stål, Hanna Nord, Jonas von Hofsten, Thorbjörn Holmlund, Farhan Shah
Desmin is a major cytoskeletal protein considered ubiquitous in mature muscle fibers. However, we earlier reported that a subgroup of muscle fibers in the soft palate of healthy subjects and obstructive sleep apnea patients (OSA) lacked immunoexpression for desmin. This raised the question of whether these fibers also lack messenger ribonucleic acid (mRNA) for desmin and can be considered a novel fiber
-
Effects of different types of Ringer’s solution on patients with traumatic haemorrhagic shock: a prospective cohort study Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-03 Qing Li, Qiang Yang, Chao Tian, Yao Guo, Hui Liu, Yadong Cheng, Shu-Zhen Bi, Jin-Hua Chen
To compare the fluid resuscitation effect of sodium acetate Ringer’s solution and sodium bicarbonate Ringer’s solution on patients with traumatic haemorrhagic shock. We conducted a prospective cohort study in our emergency department on a total of 71 patients with traumatic haemorrhagic shock admitted between 1 December 2020 and 28 February 2022. Based on the time of admission, patients were randomly
-
Triglyceride-glucose-waist circumference index predicts the incidence of cardiovascular disease in Korean populations: competing risk analysis of an 18-year prospective study Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-02 Sung Ho Ahn, Hye Sun Lee, Jun-Hyuk Lee
The triglyceride and glucose-waist circumference (TyG-WC) index demonstrated a strong association with insulin resistance, especially in Asian population. However, evidence on the association between TyG-WC index and the occurrence of cardiovascular disease (CVD) is limited. This study aimed to verify association between the TyG-WC index and the occurrence of CVD by considering all-cause mortality
-
Assessment and clinical utility of metagenomic next-generation sequencing for suspected lower respiratory tract infections Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-01 Huan Chen, Qiong Huang, Weiwei Wu, Zhiguo Wang, Wei Wang, Yigen Liu, Fangfang Ruan, Chengzhen He, Jing Li, Jia Liu, Guocheng Wu
This study aims to compare the diagnostic efficacy of metagenomic next-generation sequencing (mNGS) to traditional diagnostic methods in patients with lower respiratory tract infections (LRTIs), elucidate the etiological spectrum of these infections, and explore the impact of mNGS on guiding antimicrobial therapy. We retrospectively analyzed data from 128 patients admitted to the Respiratory Department
-
Retraction Note: Protective functions of myricetin in LPS-induced cardiomyocytes H9c2 cells injury by regulation of MALAT1 Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-01 Jinliang Sun, Jianhui Sun, Xuezhong Zhou
Retraction to: Eur J Med Res (2019) 24:20 https://doi.org/10.1186/s40001-019-0378-5 The Editors-in-Chief have retracted this article following an investigation by the National Health Commission of the People's Republic of China. The investigation found the involvement of a third party in writing and submission of the article. Additionally, concerns were raised for similar background in western blot
-
Perceptions and engagement of patients with chronic conditions on the use of medical cannabis: a scoping review Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-01 Marie-Pascale Pomey, Didier Jutras-Aswad, Jesseca Paquette, Kamilla Saadi, Mélissa Taguemout, Dina-Liza Ikene, Nathalie Arbour, Amel Zertal, Nathalie Fréjeau, Danielle Morin, Jean-Sylvain Ouellette, Kanza Alami Marrouni, Pierre Duquette
Studies generally focus on one type of chronic condition and the effect of medical cannabis (MC) on symptoms; little is known about the perceptions and engagement of patients living with chronic conditions regarding the use of MC. This scoping review aims to explore: (1) what are the dimensions addressed in studies on MC that deal with patients' perceptions of MC? and (2) how have patients been engaged
-
Evaluating biomarkers for contrast-induced nephropathy following coronary interventions: an umbrella review on meta-analyses Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-01 Abinash Mahapatro, Sara Nobakht, Sindu Mukesh, Amir Ali Daryagasht, Aishwarya Reddy Korsapati, Shika M Jain, Saman Soltani Moghadam, Rozhin Moosavi, Mona Javid, Soheil Hassanipour, Shrinidhi Vilas Prabhu, Mohammad-Hossein Keivanlou, Ehsan Amini-Salehi, Sandeep S. Nayak
Contrast-induced nephropathy (CIN) is a form of acute kidney injury (AKI) occurring in patients undergoing cardiac catheterization, such as coronary angiography (CAG) or percutaneous coronary intervention (PCI). Although the conventional criterion for CIN detection involves a rise in creatinine levels within 72 h after contrast media injection, several limitations exist in this definition. Up to now
-
Coexistence of pulmonary arterial hypertension and straight back syndrome in a patient with a novel BMPR2 variant affecting cytoplasmic tail domain Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-04-01 Mi Tang, Jun Luo, Qingqing Liu, Jie Song
Pathologic variants in the bone morphogenetic protein receptor-2 (BMPR2) gene cause a pulmonary arterial hypertension phenotype in an autosomal-dominant pattern with incomplete penetrance. Straight back syndrome is one of the causes of pseudo-heart diseases. To date, no cases of idiopathic or heritable pulmonary arterial hypertension with straight back syndrome have been reported. A 30-year-old female
-
A nomogram prediction model for hungry bone syndrome in dialysis patients with secondary hyperparathyroidism after total parathyroidectomy Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-28 Dan Gao, Yali Liu, Wenpeng Cui, Xuehong Lu, Yan Lou
Secondary hyperparathyroidism (SHPT) is a common complication of chronic kidney disease (CKD). Hungry bone syndrome (HBS) after parathyroidectomy (PTX) is a serious complication, which can lead to diarrhea, convulsion, arrhythmia and even death. This study was aimed to determine the risk factors for HBS after PTX in dialysis patients with SHPT and construct a nomogram prediction model to predict the
-
Multi-omics cluster defines the subtypes of CRC with distinct prognosis and tumor microenvironment Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-28 Yuan Ma, Jing Li, Xu Zhao, Chao Ji, Weibin Hu, YanFang Ma, Fengyi Qu, Yuchen Sun, Xiaozhi Zhang
Colorectal cancer (CRC) is a complex malignancy characterized by diverse molecular profiles, clinical outcomes, and limited precision in prognostic markers. Addressing these challenges, this study utilized multi-omics data to define consensus molecular subtypes in CRC and elucidate their association with clinical outcomes and underlying biological processes. Consensus molecular subtypes were obtained
-
Comprehensive analysis of the prognostic value and immunological role of IDO1 gene in pan-cancer Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-27 Kaili Lin, Yongfeng Wang, Fangyu Liu, Taifu You, Xiongxiong Liu, Runzhang Liu, Zeyang Li, Chunyu Zhen, Yunxia Zhang, Xingguang Liu, Hui Cai
It has been demonstrated that IDO1, a target of immune checkpoint inhibition, functions as an oncogene in the majority of human malignancies. IDO1’s function in human pan-cancers hasn’t been thoroughly studied, though. The Kaplan–Meier (K-M) and COX analyses were applied to the survival analysis. Furthermore, we used Spearman’s correlation analysis to examine the associations between IDO1 and microsatellite
-
Role of GABA pathway in motor and non-motor symptoms in Parkinson's disease: a bidirectional circuit Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-27 Bandar Alharbi, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Engy Elekhnawy, Hind Alharbi, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha
Parkinson's disease (PD) is a progressive neurodegenerative disease as a result of the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The fundamental features of PD are motor and non-motor symptoms. PD symptoms develop due to the disruption of dopaminergic neurotransmitters and other neurotransmitters such as γ-aminobutyric acid (GABA). The potential role of GABA
-
Association of novel anthropometric indices with prevalence of kidney stone disease: a population-based cross-sectional study Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-27 Xudong Hu, Xiang Li, Nan Ye, Zhenwen Zhou, Guangyuan Li, Fang Jiang
The purpose of this study was to investigate the correlation between novel anthropometric indices, specifically the body shape index (ABSI) and body roundness index (BRI), and the prevalence of kidney stone disease (KSD) within the general population of the United States (U.S.). This study employed a cross-sectional analysis of participants in the National Health and Nutrition Examination Survey from
-
Relationship between albumin-corrected anion gap and non-alcoholic fatty liver disease varied in different waist circumference groups: a cross-sectional study Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-27 Ye Lu, Ya-zhen Zhan, Wan Li, Shu-li Liao
To investigate the association of albumin-corrected anion gap (ACAG) with non-alcoholic fatty liver disease (NAFLD) and clinically significant fibrosis (CSF) defined by vibration-controlled transient elastography measurements. This cross-sectional study including 4531 participants was conducted using the data from the NHANES database of cycles 2017–2018. The outcomes were set as NAFLD vs. non-NAFLD
-
Threshold-modifying effect of the systemic inflammatory response index on kidney function decline in hypertensive patients Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-27 Xing Wei, Jing Wei, Jun Feng, Chao Li, Zhipeng Zhang, Ben Hu, Nv Long, Chunmiao Luo
Chronic kidney disease (decreased kidney function) is common in hypertensive patients. The SIRI is a novel immune biomarker. We investigated the correlation between the SIRI and kidney function in hypertensive patients. The present study analyzed data from participants who suffered from hypertension in the NHANES from 2009 to 2018. Multivariate regression analysis and subgroup analysis were used to
-
Anesthesia decision analysis using a cloud-based big data platform Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-25 Shuiting Zhang, Hui Li, Qiancheng Jing, Weiyun Shen, Wei Luo, Ruping Dai
Big data technologies have proliferated since the dawn of the cloud-computing era. Traditional data storage, extraction, transformation, and analysis technologies have thus become unsuitable for the large volume, diversity, high processing speed, and low value density of big data in medical strategies, which require the development of novel big data application technologies. In this regard, we investigated
-
2- to 20-year myelomeningocele follow-up outcomes from a referral center in Southern Iran: the Shiraz experience Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-25 Sina Zoghi, Mohammad Amin Mosayebi, Maryam Feili, Hossein Eskandari, Hadis Jalalinezhad, Mohammad Sadegh Masoudi, Reza Taheri
The current convention for treatment of children with myelomeningocele (MMC) is timely surgical intervention combined with long-term follow-up by a multidisciplinary specialized team. This study aims to investigate the outcomes of MMC patients treated at Namazi Hospital. All children presenting to Namazi Hospital with myelomeningocele between May 2001 and August 2020 were eligible for this study. For
-
Cortical lipid metabolic pathway alteration of early Alzheimer’s disease and candidate drugs screen Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-25 Linshuang Wang, Fengxue Qu, Xueyun Yu, Sixia Yang, Binbin Zhao, Yaojing Chen, Pengbo Li, Zhanjun Zhang, Junying Zhang, Xuejie Han, Dongfeng Wei
Lipid metabolism changes occur in early Alzheimer's disease (AD) patients. Yet little is known about metabolic gene changes in early AD cortex. The lipid metabolic genes selected from two datasets (GSE39420 and GSE118553) were analyzed with enrichment analysis. Protein–protein interaction network construction and correlation analyses were used to screen core genes. Literature analysis and molecular
-
Acute exacerbation of idiopathic pulmonary fibrosis disease: a diagnosis model in China Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-25 Liye Meng, Jun Xiao, Li Wang, Zhuochun Huang
To develop and validate a diagnosis model to inform risk stratified decisions for idiopathic pulmonary fibrosis patients experiencing acute exacerbations (AE-IPF). In this retrospective cohort study performed from 1 January 2016 to 31 December 2022, we used data from the West China Hospital of Sichuan University for model development and validation. Blood test results and the underlying diseases of
-
Will coronal alignment postoperatively be deteriorating in adult spinal deformity after long-fusion surgery? Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-25 Zifang Zhang, Tianhao Wang, Nianhu Li, Guoquan Zheng, Chunyang Meng
To investigate whether the coronal alignment (CA) will deteriorate, and identify the risk factors for coronal malalignment (CM) developing in adult spinal deformity (ASD) after long-fusion surgery. A multi-center retrospective study was performed, which included a total of 161 ASD patients who had undergone the surgical procedure of long-fusion (≥ 5 vertebras) with instrumentations in three medical
-
Diagnostic value of serum COMP and ADAMTS7 for intervertebral disc degeneration Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-25 Jing-Yu Ding, Xu Yan, Ren-Jie Zhang, Hua-Qing Zhang, Liang Kang, Chong-Yu Jia, Rick F. Thorne, Xiao-Ying Liu , Cai-Liang Shen
Intervertebral disc degeneration (IVDD) is a major cause of morbidity and disability. Our study aimed to investigate the potential of cartilage oligomeric matrix protein (COMP) and ADAMTS7 (A disintegrin and metalloproteinases with thrombospondin motifs 7) as biomarkers for IVDD together with their functional relationship. IVD tissues and peripheral blood samples were collected from IVDD rabbit models
-
Integrative analysis revealed a correlation of PIAS family genes expression with prognosis, immunomodulation and chemotherapy Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-25 Qiqi Zhang, Junkui Zhang, Tianyi Lan, Jiayue He, Bin Lei, Hongnan Wang, Zhiqiang Mei, Chaoxiang Lv
Protein inhibitor of activated STATs (PIAS) has pleiotropic biological effects, such as protein post-translational modification, transcriptional coregulation and gene editing. It is reported that PIAS family genes are also correlated with immune cells infiltration in cancers that highlights their unnoticed biological role in tumor progression. However, the relationship of their expression with prognosis
-
A genetic survey of patients with familial idiopathic intracranial hypertension residing in a Middle Eastern village: genetic association study Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-25 Eran Berkowitz, Tzipora C. Falik Zaccai, Dana Irge, Inbar Gur, Beatrice Tiosano, Anat Kesler
The aim of this study was to determine whether genetic variants are associated with idiopathic intracranial hypertension (IIH) in a unique village where many of the IIH patients have familial ties, a homogenous population and a high prevalence of consanguinity. Several autosomal recessive disorders are common in this village and its population is considered at a high risk for genetic disorders. The
-
Non-invasive assessment of periodontal inflammation by continuum-removal hemodynamic spectral indices Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-25 Yuan Guo, Yixiang Huang, Changping Huang, Xuejian Sun, Qingxian Luan, Lifu Zhang
Hyperspectral techniques have aroused great interest in non-invasively measuring periodontal tissue hemodynamics. However, current studies mainly focused on three typical inflammation stages (healthy, gingivitis and periodontitis) and practical approaches for using optical spectroscopy for early and precisely detection of periodontal inflammation at finer disease stages have not been well studied.
-
Phthalate exposure and blood pressure in U.S. children aged 8–17 years (NHANES 2013–2018) Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-25 Tan Cheng, Chengcheng Lou, Xiaoping Jing, Sirui Ding, Haifa Hong, Guodong Ding, Li Shen
Current evidence from epidemiologic studies suggested that phthalate metabolites might be associated with blood pressure (BP) changes. However, the special relationship between phthalate metabolites and BP changes in children has not been clearly elucidated in existing researches. We investigated the links between phthalate metabolites and various BP parameters, including systolic/diastolic BP, mean
-
Clinicopathological and molecular genetic alterations in monomorphic–epitheliotropic intestinal T-cell lymphoma of the small intestine Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-23 Bing Zhou, Min Guo, Xiaohua Li, Ting Duan, Lizi Peng, Hua Hao
Small intestinal monomorphic–epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare aggressive T-cell lymphoma originating in the gastrointestinal tract. This study aimed to investigate the clinicopathological features, immunophenotypes, and molecular genetic changes of MEITL. The clinicopathological data for three patients with surgically resected MEITL of the small intestine were collected
-
Exploring the role of genetic variations in NAFLD: implications for disease pathogenesis and precision medicine approaches Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-20 Seyedeh Kosar Mahmoudi, Shadi Tarzemani, Taha Aghajanzadeh, Mohammadreza Kasravi, Behzad Hatami, Mohammad Reza Zali, Kaveh Baghaei
Non-alcoholic fatty liver disease (NAFLD) is one of the leading causes of chronic liver diseases, affecting more than one-quarter of people worldwide. Hepatic steatosis can progress to more severe forms of NAFLD, including NASH and cirrhosis. It also may develop secondary diseases such as diabetes and cardiovascular disease. Genetic and environmental factors regulate NAFLD incidence and progression
-
Antibiotic exposure during pregnancy increases risk for childhood atopic diseases: a nationwide cohort study Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-20 Sheng-Kang Tai, Yi-Hsuan Lin, Ching-Heng Lin, Ming-Chih Lin
The prevalence of atopic diseases has increased in recent decades. A possible link between antibiotic use during pregnancy and childhood atopic disease has been proposed. The aim of this study is to explore the association of antibiotic exposure during pregnancy with childhood atopic diseases from a nationwide, population-based perspective. This was a nationwide population-based cohort study. Taiwan’s
-
Abnormal levels of expression of microRNAs in peripheral blood of patients with traumatic brain injury are induced by microglial activation and correlated with severity of injury Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-20 Shuo Feng, Zhangying Wu, Xianping Zheng, Zhiwei Shao, Qiang Lin, Shoutian Sun
Microglia play a crucial role in regulating the progression of traumatic brain injury (TBI). In specific, microglia can self-activate and secrete various substances that exacerbate or alleviate the neuroimmune response to TBI. In addition, microRNAs (miRNAs) are involved in the functional regulation of microglia. However, molecular markers that reflect the dynamics of TBI have not yet been found in
-
Systematic review of the molecular basis of hereditary breast and ovarian cancer syndrome in Brazil: the current scenario Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-20 Andreza Amália de Freitas Ribeiro, Nilson Moreira Cipriano Junior, Luciana Lara dos Santos
A detailed understanding of the genetic basis of cancer is of great interest to public health monitoring programs. Although many studies have been conducted in Brazil, a global view on the molecular profile related to hereditary breast and ovarian cancer (HBOC) in this large and heterogeneous population is lacking. A systematic review following the PRISMA guidelines was conducted in three electronic
-
Inflammatory bowel disease is associated with an increase in the incidence of multiple sclerosis: a retrospective cohort study of 24,934 patients Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-20 Kaneschka Yaqubi, Karel Kostev, Isabel Klein, Sofia Schüssler, Petra May, Tom Luedde, Christoph Roderburg, Sven H. Loosen
Recent data suggest a potential pathophysiological link between inflammatory bowel disease (IBD) and multiple sclerosis (MS), two immune-mediated diseases both of which can have a significant impact on patients' quality of life. In the present manuscript, we investigate the association between IBD and MS in a German cohort of general practice patients. These results may have important implications
-
Anti-reflux mucosectomy (ARMS) for refractory gastroesophageal reflux disease Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-18 Xian Zhu, Jianwei Shen
Gastroesophageal reflux disease (GERD) is one of the most common diseases seen by gastroenterologists worldwide. A significant proportion of patients have a suboptimal response to acid inhibitors, especially proton pump inhibitors and potassium-competitive acid blockers. Due to concerns regarding the safety of long-term medication, many patients are unwilling to take lifelong medication. Endoscopic
-
Effect of follicle size on pregnancy outcomes in patients undergoing first letrozole-intrauterine insemination Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-18 Li Ling, Di Xia, Yihan Jin, Renyun Hong, Jing Wang, Yuanjiao Liang
Letrozole has been proven to be an effective method for inducing ovulation. However, little attention has been paid to whether the lead follicle size will affect the success rate of intrauterine insemination (IUI) with ovulation induction with alone letrozole. Therefore, we hope to investigate the effect of dominant follicle size on pregnancy outcomes on human chorionic gonadotropin (hCG) day of the
-
Kangxianling formula attenuates renal fibrosis by regulating gut microbiota Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-18 Pengyu Tao, Haiyan Liu, Guangjian Hou, Jianrao Lu, Yukun Xu
Renal fibrosis (RF) produced adverse effect on kidney function. Recently, intestinal dysbiosis is a key regulator that promotes the formation of renal fibrosis. This study will focus on exploring the protective mechanism of Kangxianling Formula (KXL) on renal fibrosis from the perspective of intestinal flora. Unilateral Ureteral Obstruction (UUO) was used to construct rats’ model with RF, and receive
-
The efficacy and safety of cannabidiol (CBD) in pediatric patients with Dravet Syndrome: a narrative review of clinical trials Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-18 Nicholas Aderinto, Gbolahan Olatunji, Emmanuel Kokori, Yusuf Ismaila Ajayi, Olumide Akinmoju, Abiola Samuel Ayedun, Oluwapelumi Ikeoluwa Ayoola, Noah Oluwaseun Aderinto
Dravet Syndrome (DS) is a rare and severe form of childhood epilepsy that is often refractory to conventional antiepileptic drugs. Emerging evidence suggests that Cannabidiol (CBD) offer therapeutic benefits for DS. This review aims to evaluate the efficacy and safety of CBD in pediatric patients with DS based on data from ten clinical trials. A review was conducted to identify clinical trials assessing
-
The natural history and burden of illness of metachromatic leukodystrophy: a systematic literature review Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-18 Shun-Chiao Chang, Christian Stefan Eichinger, Polly Field
Metachromatic leukodystrophy (MLD; OMIM 250100 and 249900) is a rare lysosomal storage disease caused by deficient arylsulfatase A activity, leading to accumulation of sulfatides in the nervous system. This systematic literature review aimed to explore the effect of MLD on the lives of patients. The Ovid platform was used to search Embase, MEDLINE, and the Cochrane Library for articles related to the
-
Construction of a gene model related to the prognosis of patients with gastric cancer receiving immunotherapy and exploration of COX7A1 gene function Eur. J. Med. Res. (IF 4.2) Pub Date : 2024-03-17 Si-yu Wang, Yu-xin Wang, Ao Shen, Xian-qi Yang, Cheng-cai Liang, Run-jie Huang, Rui Jian, Nan An, Yu-long Xiao, Li-shuai Wang, Yin Zhao, Chuan Lin, Chang-ping Wang, Zhi-ping Yuan, Shu-qiang Yuan
GC is a highly heterogeneous tumor with different responses to immunotherapy, and the positive response depends on the unique interaction between the tumor and the tumor microenvironment (TME). However, the currently available methods for prognostic prediction are not satisfactory. Therefore, this study aims to construct a novel model that integrates relevant gene sets to predict the clinical efficacy