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Ginsenoside Rd Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Inflammation and Apoptosis through PI3K/Akt Signaling Pathway Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-04-05 Yuanping Wang, Jiading Zheng, Xieyang Xiao, Cailing Feng, Yinghong Li, Hui Su, Ding Yuan, Qinghai Wang, Peihong Huang, Lili Jin
Myocardial ischemia/reperfusion (I/R) injury is the leading cause of death worldwide. Ginsenoside Rd (GRd) has cardioprotective properties but its efficacy and mechanism of action in myocardial I/R injury have not been clarified. This study investigated GRd as a potent therapeutic agent for myocardial I/R injury. Oxygen-glucose deprivation and reperfusion (OGD/R) and left anterior descending (LAD)
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Glycyrrhizin and the Related Preparations: An Inspiring Resource for the Treatment of Liver Diseases Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-04-01 Yu Mou, Wenhao Liao, Yuchen Li, Lina Wan, Jingwen Liu, Xialing Luo, Hongping Shen, Qin Sun, Jing Wang, Jianyuan Tang, Zhilei Wang
Liver diseases and their related complications endanger the health of millions of people worldwide. The prevention and treatment of liver diseases are still serious challenges both in China and globally. With the improvement of living standards, the prevalence of metabolic liver diseases, including non-alcoholic fatty liver disease and alcoholic liver disease, has increased at an alarming rate, resulting
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Mangiferin, a Potential Supplement to Improve Metabolic Syndrome: Current Status and Future Opportunities Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-03-26 Gelin Xiang, Sa Guo, Nan Xing, Qinyun Du, Jing Qin, Huimin Gao, Yi Zhang, Shaohui Wang
Metabolic syndrome (MetS) represents a considerable clinical and public health burden worldwide. Mangiferin (MF), a flavonoid compound present in diverse species such as mango (Mangifera indica L.), papaya (Pseudocydonia sinensis (Thouin) C. K. Schneid.), zhimu (Anemarrhena asphodeloides Bunge), and honeybush tea (Cyclopia genistoides), boasts a broad array of pharmacological effects. It holds promising
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Astragalus membranaceus Polysaccharide Regulates Small Intestinal Microbes and Activates IL-22 Signal Pathway to Promote Intestinal Stem Cell Regeneration in Aging Mice Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-03-26 Jia-Ting Yin, Ming-Ruo Zhang, Shu Zhang, Shu-Hui Yang, Jian-Ping Li, Yun Liu, Jin-Ao Duan, Jian-Ming Guo
Aging can cause degenerative changes in multiple tissues and organs. Gastrointestinal diseases and dysfunctions are common in the elderly population. In this study, we investigated the effects of Astragalus membranaceus polysaccharide (APS) and Astragalus membranaceus ethanol extract (AEE) on age-related intestinal dysfunction and gut microbiota dysbiosis in naturally aging mice. The energy expenditure
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Components from Curcuma longa (Turmeric) Against Hepatobiliary Diseases Based on Gut–Liver Axis: Pharmacotherapeutic Properties and Potential Clinical Applications Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-03-16 Tianhui Gao, Shuyi Wang, Zongping Zhu, Liting Lin, Yirong Luo, Meigui Lu, Wan Liao
Turmeric is widely used worldwide, and there are many examples of its use in treating hepatobiliary diseases. The gut–liver axis is a bidirectional relationship between gut microorganisms and the liver that is closely related to the pathogenesis of hepatobiliary diseases. This review systematically summarizes the components of turmeric. It links the studies on turmeric affecting gut microorganisms
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Astragaloside IV Alleviates Doxorubicin-Induced Cardiotoxicity by Inhibiting Cardiomyocyte Pyroptosis through the SIRT1/NLRP3 Pathway Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-03-16 Wencong Tian, Ping Zhang, Lei Yang, Peng Song, Jia Zhao, Hongzhi Wang, Yongjie Zhao, Lei Cao
Doxorubicin (DOX) is a powerful anthracycline antineoplastic drug used to treat a wide spectrum of tumors. However, its clinical application is limited due to cardiotoxic side effects. Astragaloside IV (AS IV), one of the major compounds present in aqueous extracts of Astragalus membranaceus, possesses potent cardiovascular protective properties, but the underlying molecular mechanisms are unclear
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Quercetin Limits Tumor Immune Escape through PDK1/CD47 Axis in Melanoma Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-03-16 Xin Li, Xue He, Bing Lin, Li Li, Qifeng Deng, Chengzhi Wang, Jing Zhang, Ying Chen, Jingyi Zhao, Xinrui Li, Yan Li, Qing Xi, Rongxin Zhang
Quercetin (3,3′,4′,5,7-pentahydroxyflavone) is a bioactive plant-derived flavonoid, abundant in fruits and vegetables, that can effectively inhibit the growth of many types of tumors without toxicity. Nevertheless, the effect of quercetin on melanoma immunology has yet to be determined. This study aimed to investigate the role and mechanism of the antitumor immunity action of quercetin in melanoma
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Natural Products in the Modulation of Farnesoid X Receptor Against Nonalcoholic Fatty Liver Disease Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-03-14 Jing Wang, Na Yang, Yu Xu
Nonalcoholic fatty liver disease (NAFLD) is a global health concern with a high prevalence and increasing economic burden, but official medicine remains unavailable. Farnesoid X receptor (FXR), a nuclear receptor member, is one of the most promising drug targets for NAFLD therapy that plays a crucial role in modulating bile acid, glucose, and lipid homeostasis, as well as inhibits hepatic inflammation
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Red Yeast Rice and Statin Therapy in Patients with Hypercholesterolemia and the Comorbidities: A Retrospective Cohort Study on Lipid-Lowering Effects and Cardiovascular Outcomes Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-03-14 Tun-Pin Hsueh, Wan-Ling Lin, Wen-Long Hu, Yu-Chiang Hung
Red yeast rice (RYR) is known for its lipid-lowering effects in patients with hypercholesterolemia; however, its comparative efficacy with statins and risk reduction remains uncertain. This retrospective study analyzed data from 337,104 patients with hyperlipidemia in the Chang Gung Research Database cohort, spanning from January 2016 to December 2021. Exclusion criteria were applied to ensure data
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Apigenin Suppresses Innate Immune Responses and Ameliorates Lipopolysaccharide-Induced Inflammation via Inhibition of STING/IRF3 Pathway Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-03-14 Xu-Wei Zhou, Juan Wang, Wen-Fu Tan
The stimulator of interferon genes (STING) signaling pathway is crucial for the pathogenesis of autoimmune and inflammatory disorders, including acute lung injury (ALI). Apigenin (4′,5,7-trihydroxyflavone) is a natural flavonoid widely found in fruits, vegetables, and Chinese medicinal herbs that exhibits a range of pharmacological effects, such as antibacterial and anti-inflammatory activities. However
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Eugenol Possesses Colitis Protective Effects: Impacts on the TLR4/MyD88/NF-κB Pathway, Intestinal Epithelial Barrier, and Macrophage Polarization Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-03-14 Jun-Jie Huang, Yue-Min Feng, Shu-Mei Zheng, Cheng-Long Yu, Rui-Gang Zhou, Ming-Jiang Liu, Ruo-Nan Bo, Jie Yu, Jin-Gui Li
Eugenol (EU) has been shown to ameliorate experimental colitis due to its anti-oxidant and anti-inflammatory bioactivities. In this study, DSS-induced acute colitis was established and applied to clarify the regulation efficacy of EU on intestinal barrier impairment and macrophage polarization imbalance along with the inflammatory response. Besides, the adjusting effect of EU on macrophages was further
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Curcumin Analog L48H37 Induces Apoptosis in Human Oral Cancer Cells by Activating Caspase Cascades and Downregulating the Inhibitor of Apoptosis Proteins through JNK/p38 Signaling Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-03-14 Chun-Wen Su, Shao-Hsuan Kao, Yi-Tzu Chen, Yi-Hsien Hsieh, Wei-En Yang, Meng-Ying Tsai, Chiao-Wen Lin, Shun-Fa Yang
L48H37 is a synthetic curcumin analog that has anticancer potentials. Here, we further explored the anticancer effect of L48H37 on oral cancer cells and its mechanistic acts. Cell cycle distribution was assessed using flow cytometric analysis. Apoptosis was elucidated by staining with PI/Annexin V and activation of the caspase cascade. Cellular signaling was explored using apoptotic protein profiling
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Phytochemistry of Red Ginseng, a Steam-Processed Panax ginseng Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-02-14 Chong-Zhi Wang, Chun-Feng Zhang, Qi-Hui Zhang, Chun-Su Yuan
Asian ginseng, the root of Panax ginseng C.A. Meyer, occupies a prominent position in the list of best-selling natural products in the world. There are two major types of ginseng roots: white ginseng and red ginseng, each with numerous preparations. White ginseng is prepared by air-drying fresh Asian ginseng roots after harvest. Red ginseng is prepared by steaming roots in controlled conditions using
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Efficacy and Mechanisms of Natural Products as Therapeutic Interventions for Chronic Respiratory Diseases Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-02-14 Fanli Jin, Pengbei Fan, Yuanyuan Wu, Qingzhen Yang, Jiansheng Li, Han Liu
Chronic respiratory diseases are long-term conditions affecting the airways and other lung components that are characterized by a high prevalence, disability rate, and mortality rate. Further optimization of their treatment is required. Natural products, primarily extracted from organisms, possess specific molecular and structural formulas as well as distinct chemical and physical properties. These
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Mechanism of Acupuncture in Treating Obesity: Advances and Prospects Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-02-08 Mi-Na Wang, Miao-Xin Zhai, Yi-Tong Wang, Qiu-Fu Dai, Lu Liu, Luo-Peng Zhao, Qiu-Yu Xia, Shen Li, Bin Li
Obesity is a common metabolic syndrome that causes a significant burden on individuals and society. Conventional therapies include lifestyle interventions, bariatric surgery, and pharmacological therapies, which are not effective and have a high risk of adverse events. Acupuncture is an effective alternative for obesity, it modulates the hypothalamus, sympathetic activity and parasympathetic activity
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The Landscape of Gut Microbiota and Its Metabolites: A Key to Understanding the Pathophysiology of Pattern in Chinese Medicine Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-02-08 Zhaozhou Zhang, Liqing Du, Qiuchen Ji, Hao Liu, Zhenxing Ren, Guang Ji, Zhao-Xiang Bian, Ling Zhao
Liver Stagnation and Spleen Deficiency (LSSD) is a Chinese Medicine (CM) pattern commonly observed in gastrointestinal (GI) diseases, yet its biological nature remains unknown. This limits the global use of CM medications for treating GI diseases. Recent studies emphasize the role of gut microbiota and their metabolites in the pathogenesis and treatment of LSSD-associated GI diseases. There is increasing
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Taraxacum: A Review of Ethnopharmacology, Phytochemistry and Pharmacological Activity Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-02-08 Fusheng Hao, Xinxin Deng, Xin Yu, Wen Wang, Wei Yan, Xi Zhao, Xiaofei Wang, Changcai Bai, Zhizhong Wang, Lu Han
Taraxacum refers to the genus Taraxacum, which has a long history of use as a medicinal plant and is widely distributed around the world. There are over 2500 species in the genus Taraxacum recorded as medicinal plants in China, Central Asia, Europe, and the Americas. It has traditionally been used for detoxification, diuresis, liver protection, the treatment of various inflammations, antimicrobial
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Berberine Metabolites Stimulate GLP-1 Secretion by Alleviating Oxidative Stress and Mitochondrial Dysfunction Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-02-08 Wei-Li Yang, Chen-Yang Zhang, Wen-Yi Ji, Li-Li Zhao, Fang-Yuan Yang, Lin Zhang, Xi Cao
Berberine (BBR) is a principal component of Rhizoma coptidis known for its therapeutic potential in treating diseases such as type 2 diabetes mellitus (T2DM) and obesity. Despite the trace levels of BBR in plasma, it’s believed that its metabolites play a pivotal role in its biological activities. While BBR is recognized to promote GLP-1 production in intestinal L cells, the cytoprotective effects
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The Effectiveness of Traditional Chinese Medicine in Treating Malignancies via Regulatory Cell Death Pathways and the Tumor Immune Microenvironment: A Review of Recent Advances Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-02-07 Jingya Fu, Xiaoxia Xie, Huimin Yao, Haijuan Xiao, Zhuoqun Li, Zhenzhi Wang, Ran Ju, Yan Zhao, Zhijun Liu, Nana Zhang
Traditional Chinese Medicine (TCM) has achieved high clinical efficacy in treating malignancies in recent years and is thus gradually becoming an important therapy for patients with advanced tumor for its benefits in reducing side effects and improving patients’ immune status. However, it has not been internationally recognized for cancer treatment because TCM’s anti-tumor mechanism is not fully elucidated
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Ferroptosis: A New Research Direction of Artemisinin and Its Derivatives in Anti-Cancer Treatment Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-02-07 Youke Wang, Xiang Yuan, Min Ren, Zhiyu Wang
Ferroptosis, an iron-dependent cell death mechanism driven by an accumulation of lipid peroxides on cellular membranes, has emerged as a promising strategy to treat various diseases, including cancer. Ferroptosis inducers not only exhibit cytotoxic effects on multiple cancer cells, including drug-resistant cancer variants, but also hold potential as adjuncts to enhance the efficacy of other anti-cancer
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Berberine Alleviates Ischemic Brain Injury by Enhancing Autophagic Flux via Facilitation of TFEB Nuclear Translocation Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-02-07 Yi-Li Liu, Tao Guo, Yong-Jie Zhang, Shun-Cong Tang, Xiao-Ming Zhao, Hong-Yun He, Chun-Lei Yu, Yi-Hao Deng
Berberine has been demonstrated to alleviate cerebral ischemia/reperfusion injury, but its neuroprotective mechanism has yet to be understood. Studies have indicated that ischemic neuronal damage was frequently driven by autophagic/lysosomal dysfunction, which could be restored by boosting transcription factor EB (TFEB) nuclear translocation. Therefore, this study investigated the pharmacological effects
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Research Progress on the Antitumor Molecular Mechanism of Ginsenoside Rh2 Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-01-31 Lan Yang, Jenny Jie Chen, Brian Sheng-Xian Teo, Jiong Zhang, Mingqiang Jiang
Cancer has evolved into a substantial public health concern as the second-leading cause of mortality globally. Radiotherapy and chemotherapy have been the two most widely used cancer therapies in recent years; however, both have drawbacks. Therefore, the focus has shifted to the creation of herbal medicines, the extraction of active ingredients, replacement therapy, and the adverse effects of these
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Cucurbitacin B Inhibits the Malignancy of Esophageal Carcinoma through the KIF20A/JAK/STAT3 Signaling Pathway Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-01-30 Chao Liu, Jian Ji, Chenglin Li
This study intends to explore the effects of Cucurbitacin B (CuB) and KIF20A on esophageal carcinoma (ESCA). Data were downloaded from the Cancer Genome Atlas (TCGA) database. The expression properties of KIF20A have been confirmed by GEPIA and ualcan from TCGA. The expression of KIF20A was determined using western blotting in ECA109 and KYSE150 cells after transfection with KIF20A, KIF20A siRNA, or
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Cancer Pain Management with Traditional Chinese Medicine: Current Status and Future Perspectives Am. J. Chinese Med. (IF 5.7) Pub Date : 2024-01-26 Jiafu Ji, Jingxuan Guo, Yongliang Chi, Fan Su
Cancer pain, especially the moderate-to-severe pain experienced by patients with advanced cancer, is still one of the most challenging clinical problems. The current mainstream pharmacological treatment for cancer pain involves applying opioid medications and other pain-killing drugs. However, analgesic drugs have many adverse effects such as addiction, tolerance, and other formidable clinical and
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Triterpenoid Compounds from Cyclocarya paliurus: A Review of Their Phytochemistry, Quality Control, Pharmacology, and Structure-Activity Relationship. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-11-10 Shuran Zhang,Junyu He,Jie Li,Haibo He,Yumin He,Xiao Wang,Heng Shu,Jihong Zhang,Daoxiang Xu,Kun Zou
Cyclocarya paliurus (Batalin) Iljinskaja (C. paliurus) is a single species of Cyclocarya paliurus in Juglandaceae. It is a unique rare medicinal plant resource in China that is mainly distributed in the south of China. The leaves of C. paliurus, as a new food ingredient, are processed into tea products in daily life. Triterpenoids are the main active ingredient in C. paliurus. So far, 164 triterpenoid
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Coptisine, the Characteristic Constituent from Coptis chinensis, Exhibits Significant Therapeutic Potential in Treating Cancers, Metabolic and Inflammatory Diseases. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-11-04 Qiang Lu,Ying Tang,Shuang Luo,Qihai Gong,Cailan Li
Naturally derived alkaloids belong to a class of quite significant organic compounds. Coptisine, a benzyl tetrahydroisoquinoline alkaloid, is one of the major bioactive constituents in Coptis chinensis Franch., which is a famous traditional Chinese medicine. C. chinensis possesses many kinds of functions, including the ability to eliminate heat, expel dampness, purge fire, and remove noxious substances
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Coptis chinensis and Berberine Ameliorate Chronic Ulcerative Colitis: An Integrated Microbiome-Metabolomics Study. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-11-04 Rui Zhou,Yangyi Huang,Congjian Tian,Yong Yang,Zaiqi Zhang,Kai He
Coptis chinensis Franch (RC), has historically been used for the treatment of "Xiao Ke" and "Xia Li" symptoms in China. "Xia Li" is characterized by abdominal pain and diarrhea, which are similar to the clinical symptoms of ulcerative colitis (UC). For the first time, this study aims to compare the anti-colitis effects of berberine (BBR) and total RC alkaloids (TRCA) and investigate the underlying
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Andrographolide Attenuates Oxidized LDL-Induced Activation of the NLRP3 Inflammasome in Bone Marrow-Derived Macrophages and Mitigates HFCCD-Induced Atherosclerosis in Mice. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-11-04 Chih-Chieh Chen,Chong-Kuei Lii,Kai-Li Liu,Yi-Ling Lin,Chia-Wen Lo,Chien-Chun Li,Ya-Chen Yang,Haw-Wen Chen
Andrographolide (AND) is a bioactive component of the herb Andrographis paniculata and a well-known anti-inflammatory agent. Atherosclerosis is a chronic inflammatory disease of the vasculature, and oxidized LDL (oxLDL) is thought to contribute heavily to atherosclerosis-associated inflammation. The aim of this study was to investigate whether AND mitigates oxLDL-mediated foam cell formation and diet-induced
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Isoliquiritigenin Inhibits Oral Squamous Cell Carcinoma and Overcomes Chemoresistance by Destruction of Survivin. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-11-04 Zhongsu Zhou,Shuangze Han,Jinzhuang Liao,Ruirui Wang,Xinfang Yu,Ming Li
The oncoprotein survivin plays a pivotal role in controlling cell division and preventing apoptosis by inhibiting caspase activation. Its significant contribution to tumorigenesis and therapeutic resistance has been well established. Isoliquiritigenin (ISL), a natural compound, has been recognized for its powerful inhibitory effects against various tumors. However, whether ISL exerts regulatory effects
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Chinese Materia Medica in Treating Depression: The Role of Intestinal Microenvironment. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-11-04 Ruhui Shen,Zhipeng Li,Huiyun Wang,Yongchao Wang,Xiaofang Li,Qian Yang,Yingjie Fu,Ming Li,Li-Na Gao
Depression is a highly heterogeneous mental illness. Drug treatment is currently the main therapeutic strategy used in the clinic, but its efficacy is limited by the modulation of a single target, slow onset, and side effects. The gut-brain axis is of increasing interest because intestinal microenvironment disorders increase susceptibility to depression. In turn, depression affects intestinal microenvironment
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A Comprehensive Review on the Chemical Composition, Pharmacology and Clinical Applications of Ganoderma. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-10-31 Chenwang Liu,Xiaomei Song,Yuze Li,Chao Ding,Xin Li,Linwei Dan,Haonan Xu,Dongdong Zhang
Ganoderma is the dried fruiting bodiy of Ganoderma lucidum (Leyss.ex Fr.) Karst. or Ganoderma sinense Zhao, Xu et Zhang, belonging to the family Polyporaceae, which grows mainly in tropical, subtropical, and temperate regions. As a traditional Chinese medicine, Ganoderma has been used in China for more than 2000 years because of its medicinal properties, such as relieving cough and asthma, providing
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Wogonin Diminishes Radioresistance of Breast Cancer via Inhibition of the Nrf2/HIF-1[Formula: see text] Pathway. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-10-31 Ting Wang,Pinghan Wang,Song Wang,Yu Ma,Ziqiao Zhao,Fangyi Long
Radiotherapy plays a crucial role in the multimodal treatment of breast cancer. However, radioresistance poses a significant challenge to its effectiveness, hindering successful cancer therapy. Emerging evidence indicates that Nrf2 and HIF-1[Formula: see text] are critical regulators of cellular anti-oxidant responses and that their overexpression significantly promotes radioresistance. Wogonin (WG)
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Traditional Chinese Medicine in Osteoporosis Intervention and the Related Regulatory Mechanism of Gut Microbiome. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-10-27 Kun Li,Yiping Jiang,Nani Wang,Liyong Lai,Shengyan Xu,Tianshuang Xia,Xiaoqiang Yue,Hailiang Xin
The gut microbiome (GM) has become a crucial factor that can affect the progression of osteoporosis. A number of studies have demonstrated the impact of Traditional Chinese Medicine (TCM) on GM and bone metabolism. In this review, we summarize the potential mechanisms of the relationship between osteoporosis and GM disorder and introduce several natural Chinese medicines that exert anti-osteoporosis
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β-Escin: An Updated Review of Its Analysis, Pharmacology, Pharmacokinetics, and Toxicity. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-10-20 Yunyu Wang,Xiuwei Han,Xinhuan Wan,Fengjv Niu,Changzheng Zhou
[Formula: see text]-Escin is an oleanane-type pentacyclic triterpenoid saponin extracted from the seeds of Aesculus hippocastanum (AH), which is more widely distributed. [Formula: see text]-Escin sodium has been approved by the American FDA for clinical usage. This paper is intended to summarize an updated and comprehensive review of the pharmacological activities, pharmacokinetic properties, toxicity
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Pachymic Acid Prevents Hemorrhagic Shock-Induced Cardiac Injury by Suppressing M1 Macrophage Polarization and NF-[Formula: see text]B Signaling Pathway. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-10-20 Zhenfeng Liu,Wuming Zhou,Qingyang Liu,Zhirong Huan,Qiubo Wang,Xin Ge
Hemorrhagic shock (HS) is the leading cause of death in trauma patients. Inflammation following HS can lead to cardiac damage. Pachymic acid (PA), a triterpenoid extracted from Poria cocos, has been found to possess various biological activities, including anti-inflammatory and anti-apoptotic properties. Our research aims to investigate the protective effects of PA against HS-induced heart damage and
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Regulatory Effects of Quercetin on Bone Homeostasis: Research Updates and Future Perspectives. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-10-09 Yujiang Xi,Jiayan Shen,Xiahuang Li,Yi Bao,Ting Zhao,Bo Li,Xiaoyu Zhang,Jian Wang,Yanyuan Bao,Jiamei Gao,Zhaohu Xie,Qi Wang,Qiu Luo,Hongling Shi,Zhaofu Li,Dongdong Qin
The imbalance of bone homeostasis has become a major public medical problem amid the background of an aging population, which is closely related to the occurrence of osteoporosis, osteoarthritis, and fractures. Presently, most drugs used in the clinical treatment of bone homeostasis imbalance are bisphosphonates, calcitonin, estrogen receptor modulators, and biological agents that inhibit bone resorption
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Research Progress and New Perspectives of Anticancer Effects of Emodin. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-09-21 Wu Liu,Eskandar Qaed,Yuelin Zhu,Wenzhang Tian,Yizhen Wang,Le Kang,Xiaodong Ma,Zeyao Tang
Emodin is a natural compound found in several traditional Chinese medicines, including Rheum palmatum and Polygonum cuspidatum. Recent studies have shown that emodin exhibits potent anticancer effects against a variety of cancer types, including liver, breast, lung, and colon cancer. Emodin's anticancer effects are mediated through several mechanisms, including inhibition of cell proliferation, induction
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Ginsenoside Rg5 Improves Sleep by Regulating Energy Metabolism in Sleep-Deprived Rats. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-09-04 Jian-Bo Chen,Mei-Jia Li,Xiao-Hui Huo,Tie-Jun Gong,Xiao Han,Jin-Hui Liu,Shuang Liu,Yin-Shi Sun
Sleep deprivation (SD) has become a universal social problem. There is a causal relationship between SD and energy metabolism disorder. Phytochemicals have been demonstrated to have excellent sleep-promoting effects, and studies have shown that ginsenoside Rg5 (Rg5) exerts sedative and hypnotic effects. The present study aimed to investigate the role of Rg5 in regulating energy metabolism and explore
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Ruscogenin Alleviates Myocardial Ischemia via Myosin IIA-Dependent Mitochondrial Fusion and Fission Balance. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-08-31 Jin-Cheng Liu,Qing-Fei Zhao,Ling Zhang,Bo-Yang Yu,Fang Li,Jun-Ping Kou
Ruscogenin (RUS), a major effective steroidal sapogenin derived from Ophiopogon japonicas, has been reported to alleviate myocardial ischemia (MI), but its cardioprotective mechanism is still not completely clear. In this study, we observed that RUS markedly reduced MI-induced myocardial injury, as evidenced by notable reductions in infarct size, improvement in biochemical markers, alleviation of cardiac
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A Novel Paradigm Defines Functional Molecule Clusters for an Anti-Alzheimer's Disease Recipe from Traditional Chinese Medicine. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-08-31 Peiyi Ji,Jianrong Xu,Miaomiao Li,Chenghuan Song,Yongfang Zhang,Rui Zhang,Hongzhuan Chen,Hao Wang,Lanxue Zhao
Traditional Chinese Medicine (TCM) prescriptions are organically composed of compatible herbs according to the TCM theory. The complex ingredients of TCM could act on multiple targets through various pathways simultaneously to exert pharmacological effects, making TCM an unrivaled gem in the medical world. However, due to a lack of comprehensive and standard study methods, the research of TCM products
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Bergenin Inhibits Tumor Growth and Overcomes Radioresistance by Targeting Aerobic Glycolysis. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-08-30 Xiaoying Li,Li Xie,Li Zhou,Yu Gan,Shuangze Han,Yuanfeng Zhou,Xiang Qing,Wei Li
Hexokinase 2 (HK2), the first glycolytic rate-limiting enzyme, is closely correlated with the occurrence and progression of tumors. Effective therapeutic agents targeting HK2 are urgently needed. Bergenin has exhibited various pharmacological activities, such as antitumor properties. However, the effects of bergenin on the abnormal glucose metabolism of cancer cells are yet unclear. In this study,
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A New Perspective on Metabolites and Bioactive Compounds from Fungi. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-08-30 Thananjeyan Balasubramaniyam,Seo-Ree Choi,Vinod Kumar Nathan,Abhishikta Basu,Joon-Hwa Lee
Fungi play an important role in the solution to important global problems. Making use of processes and goods that are based on fungi can help promote sustainability by making the most efficient use of natural resources. Fungi stand apart from other organisms due to their extraordinary capacity to generate organic compounds. They are necessary for the psychological and physiological well-being of people
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Effects and Mechanistic Role of Mulberry Leaves in Treating Diabetes and its Complications. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-08-30 Yanjiao Zhang,Runyu Miao,Kaile Ma,Yuxin Zhang,Xinyi Fang,Jiahua Wei,Ruiyang Yin,Jingxue Zhao,Jiaxing Tian
Diabetes mellitus (DM) has become a surge burden worldwide owing to its high prevalence and range of associated complications such as coronary artery disease, blindness, stroke, and renal failure. Accordingly, the treatment and management of DM have become a research hotspot. Mulberry leaves (Morus alba L.) have been used in Traditional Chinese Medicine for a long time, with the first record of its
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Effects of Chinese Medicine on Pyroptosis in Coronary Heart Disease. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-08-30 Chuangpeng Li,Qingqing Liu,Qiuxiong Chen,Peizhong Liu,Dawei Wang,Rongyuan Yang,Qing Liu
Pyroptosis, an apoptotic pathway for pro-inflammatory cells, has attracted attention from researchers because of its role in the development of cardiac inflammation reactions. Chinese medicine (CM) has been given more and more attention during the pursuit of a treatment for coronary heart disease (CHD). Evidence suggests that myocardial cell pyroptosis affects the progression of CHD. Pyroptosis pathways
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Pharmacological Benefits and Underlying Mechanisms of Salvia miltiorrhiza against Molecular Pathology of Various Liver Diseases: A Review. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-08-30 Cho Hyun Hwang,Eungyeong Jang,Jang-Hoon Lee
Salvia miltiorrhiza Bunge, called Danshen in Chinese, is the dried root and rhizome of S. miltiorrhiza, which is part of the mint family, Lamiaceae; it has chiefly been used to treat blood stasis and improve blood flow in cerebrovascular and cardiovascular diseases for over 2000 years. Recent preclinical studies have indicated that S. miltiorrhiza has a wide range of pharmacological properties making
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The Role of Traditional Chinese Medicine in Cancer Immunotherapy: Current Status and Future Directions. Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-08-28 Jinxin Xie,Huiming Huang,Xingxing Li,Lishan Ouyang,Longyan Wang,Dongxiao Liu,Xuejiao Wei,Peng Tan,Pengfei Tu,Zhongdong Hu
The tumor microenvironment (TME) plays an important role in the development of tumors. Immunoregulatory cells and cytokines facilitate cancer cells to avoid immune surveillance. Overexpression of immune checkpoint molecules such as CTLA-4 and PD-1/PD-L1 inhibits immune function and enables cancer cells to avoid clearance by the immune system. Thus, minimizing tumor immunosuppression could be an important
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Mangiferin Protects Against Angiotensin-II-Enhanced Hypertrophic Markers and Apoptosis in H9c2 Cardiomyocytes Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-08-23 Chih-Chia Chang, Kun-Ling Tsai, Hui-Ching Cheng, Wan-Ching Chou, Yu-Ting Huang, Pei-Ling Hsieh, Shin-Da Lee
Hypertrophic cardiomyopathy accompanies numerous cardiovascular diseases, and the intervention of cardiac hypertrophy is an important issue to prevent detrimental consequences. Mangiferin (MGN) is a glucosylxanthone found in Mangifera indica, which exhibits anti-oxidant and anti-inflammatory properties. Various studies have demonstrated the cardioprotective potential of MGN, but the mechanisms behind
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Effectiveness of Chinese Herbal Medicine in Patients with COVID-19 During the Omicron Wave in Hong Kong: A Retrospective Case-Controlled Study Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-08-19 Jialing Zhang, Jingyuan Luo, Hiu To Tang, Hoi Ki Wong, Yanfang Ma, Duoli Xie, Bo Peng, Aiping Lyu, Chun Hoi Cheung, Zhaoxiang Bian
SARS-CoV-2 Omicron led to the most serious outbreak of COVID-19 in Hong Kong in 2022. Under the pressure of a high volume of patients and limited medical resources, Chinese herbal medicine (CHM) has been extensively used. This is a case-control study of the infected patients that aims to evaluate the effectiveness of CHM using data extracted from the Hong Kong Baptist University Telemedicine Chinese
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Review on Processing Methods of Toxic Chinese Materia Medica and the Related Mechanisms of Action Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-08-04 Lingyun Pan, Yingshu Wang, Lixia Yue, Nan Wang, Wen Xu, Xue Liao, Haiying Wang, Yanfeng Xiu
Toxic Chinese materia medica (CMM) has both pharmacological activities and toxic effects. Based on thousands of years of experience in the application of CMMs, people have explored many practical processing methods of CMMs, also known as “Pao Zhi”, to reduce/control toxicity and preserve/enhance efficacy. Toxic CMMs have been used throughout China’s hospitals. Yet, the production and use of toxic CMM
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Chicoric Acid Presented NLRP3-Mediated Pyroptosis through Mitochondrial Damage by PDPK1 Ubiquitination in an Acute Lung Injury Model Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-08-03 Weiwei Zhang, Min Zhao, Zhichen Pu, Qin Yin, Yinping Shui
Chicoric acid (CA), a functional food ingredient, is a caffeic acid derivative that is mainly found in lettuce, pulsatilla, and other natural plants. However, the anti-inflammatory effects of CA in acute lung injury (ALI) remain poorly understood. This study was conducted to investigate potential drug usage of CA for ALI and the underlying molecular mechanisms of inflammation. C57BL/6 mice were given
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Astragalus membranaceus as a Drug Candidate for Inflammatory Bowel Disease: The Preclinical Evidence Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-08-03 Min Hou, Yufang Leng, Yajing Shi, Zhiguo Tan, Xiangzhen Min
Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders that include Crohn’s disease (CD) and ulcerative colitis (UC). Today, IBD has no successful treatment. As a result, it is of paramount importance to develop novel therapeutic agents for IBD prevention and treatment. Astragalus membranaceus (AMS) is a traditional Chinese medicine found in the AMS root. Modern pharmacological
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Effects of Rosa roxburghii Tratt on Ulcerative Colitis: An Integrated Analysis of Network Pharmacology and Experimental Validation Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-08-02 Yu-Hong Kang, Ting Zhou, Shou-Xun Wu, Xing-Jie Li, Xiao-Yi Huang, Rui Xia, Yi-Han Ling, He-Ting Zhou, Shu-Wen Zhang, Wen-Ya Yin
Rosa roxburghii Tratt is a traditional Chinese plant that has been used to treat different inflammatory diseases. The purpose of this study was to investigate the mechanism of action of Rosa roxburghii Tratt extract (RRTE) against ulcerative colitis (UC) using network pharmacology and experimental validation. HPLC-Q/Orbitrap MS was used to rapidly identify the substances contained in RRTE after extracting
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Coptis chinensis-Induced Changes in Metabolomics and Gut Microbiota in Rats Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-08-02 Yong-Xiang Wang, Jin-Ying Zhang, Yu-Min Cao, Tong Liu, Zhen-Kai Zhang, Bing-Xian Zhang, Wei-Sheng Feng, Kai Li, Xiao-Ke Zheng, Ning Zhou
Rhizoma coptidis (CR) is traditionally used for treating gastrointestinal diseases. Wine-processed CR (wCR), zingiber-processed CR (zCR), and evodia-processed CR (eCR) are its major processed products. However, the related study of their specific mechanisms is very limited, and they need to be further clarified. The aim of this study is to compare the intervening mechanism of wCR/zCR/eCR on rats via
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IL-10-dependent Effect of Chinese Medicine Abelmoschus manihot on Alleviating Intestinal Inflammation and Modulating Gut Microbiota Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-07-31 Cheng-Xi Li, Yu-Meng Wang, Wen-Jing Zhang, Shu Zhang, Jian-Ping Li, Tong Zhou, Jin-Ao Duan, Jian-Ming Guo
Inflammatory bowel disease (IBD) is a recurrent disease associated with a potential risk of colorectal cancer. Abelmoschus manihot (AM), a Chinese herbal medicine, is known to alleviate IBD. However, its mechanism of action requires further clarification. Here, we focused on the role of IL-10 and the gut microbiota in the mechanism of action of AM. The effects of AM on intestinal inflammation, mucus
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Schisanhenol Attenuates OxLDL-Induced Endothelial Dysfunction via an AMPK-Dependent Mechanism Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-07-29 Tsan-Hung Chiu, Chang-Wen Ku, Tsung-Jung Ho, Kun-Ling Tsai, Wei-Ching Hsu, Yu-An Chen, Hsiu-Chung Ou, Hsiu-I Chen
Atherosclerotic cardiovascular diseases, commonly known as the formation of fibrofatty lesions in the artery wall, are the leading causes of death globally. Oxidized low-density lipoprotein (oxLDL) is one of the major components of atherosclerotic plaques. It is evident that dietary supplementation containing sources of antioxidants can prevent atherogenic diseases. Schisanhenol (SAL), a dibenzocyclooctene
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Korean Red Ginseng Relieves Inflammation and Modulates Immune Response Induced by Pseudo-Type SARS-CoV-2 Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-07-25 Ki Woong Kwon, Ji Won Kim, Seokoh Moon, Jeong Hyeon Yoon, Soo-Hyun Youn, Sun Hee Hyun, Han Gyung Kim, Dae-Hyuk Kweon, Jae Youl Cho
Few studies have reported the therapeutic effects of Korean red ginseng (KRG) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the positive effects of KRG on other viruses have been reported and the effects of KRG on pulmonary inflammatory diseases have also been studied. Therefore, this study investigated the therapeutic effects of KRG-water extract (KRG-WE) in a pseudo-type
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The Effects of Cinobufagin on Hepatocellular Carcinoma Cells Enhanced by MRT68921, an Autophagy Inhibitor Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-07-25 Zhongwei Xu, Jun Bao, Xiaohan Jin, Heng Li, Kaiyuan Fan, Zhidong Wu, Min Yao, Yan Zhang, Gang Liu, Dan Wang, Xiaoping Yu, Jia Guo, Ruicheng Xu, Qian Gong, Fengmei Wang, Jin Wang
Cinobufagin, a cardiotonic steroid derived from toad venom extracts, exhibits significant anticancer properties by inhibiting Na+/K+-ATPase in cancer cells. It is frequently used in clinical settings to treat advanced-stage cancer patients, improving their quality of life and survival time. However, its long-term use can result in multidrug resistance to other chemotherapy drugs, and the exact mechanism
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Research Progress of Immunomodulation on Anti-COVID-19 and the Effective Components from Traditional Chinese Medicine Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-07-19 Ting Hu, Li Li, Qin Ma
SARS-CoV-2 has posed a threat to the health of people around the world because of its strong transmission and high virulence. Currently, there is no specific medicine for the treatment of COVID-19. However, for a wide variety of medicines used to treat COVID-19, traditional Chinese medicine (TCM) plays a major role. In this paper, the effective treatment of COVID-19 using TCM was consulted first, and
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Effects of Curcuminoids and Surfactant-Formulated Curcumin on Chemo-Resistant Colorectal Cancer Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-07-19 Chunping Wan, Qinge Ma, Samantha Anderson, Qi-Hui Zhang, Chun-Feng Zhang, Angela H. Wang, Emma Bell, Lifei Hou, Chun-Su Yuan, Chong-Zhi Wang
Colorectal cancer (CRC) is a leading cause of cancer-related death in the United States, and chronic gut inflammation is a risk factor for CRC initiation and development. Curcuma longa L., or turmeric, has become one of the most studied herbal medicines in recent years due to its anticancer potentials. It is generally accepted that the major component in turmeric is curcuminoids, and the active constituent
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New Perspectives on Chinese Medicine in Treating Hepatic Fibrosis: Lipid Droplets in Hepatic Stellate Cells Am. J. Chinese Med. (IF 5.7) Pub Date : 2023-07-10 Chang Shao, Huihui Xu, Xiguang Sun, Yan Huang, Wenqin Guo, Yi He, Linmao Ye, Zhili Wang, Jiaxin Huang, Xiaofan Liang, Junjie Zhang
Hepatic fibrosis (HF) is a wound healing response featuring excessive deposition of the extracellular matrix (ECM) and activation of hepatic stellate cells (HSCs) that occurs during chronic liver injury. As an initial stage of various liver diseases, HF is a reversible pathological process that, if left unchecked, can escalate into cirrhosis, liver failure, and liver cancer. HF is a life-threatening