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Exploration of the prognostic prediction value of the PANoptosis‐based risk score and its correlation with tumor immunity in lung adenocarcinoma J. Gene Med. (IF 3.5) Pub Date : 2024-03-20 Xiaojian Zhao, Xuefeng Zhang, Feng Li, Caiping Lu
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Comprehensive analysis of histone acetylation‐related genes in glioblastoma and lower‐grade gliomas: Insights into drug sensitivity, molecular subtypes, immune infiltration, and prognosis J. Gene Med. (IF 3.5) Pub Date : 2024-03-19 Jiajun Qin, Jin Fu, Xianzhen Chen
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Overexpression of multidrug resistance‐associated protein 1 protects against cardiotoxicity by augmenting the doxorubicin efflux from cardiomyocytes J. Gene Med. (IF 3.5) Pub Date : 2024-03-14 Cindy Y. Kok, Sindhu Igoor, Renuka Rao, Shinya Tsurusaki, Tracy Titus, Lauren M. MacLean, Megha Kadian, Rhys Skelton, James J. H. Chong, Eddy Kizana
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Exploration of YBX1 role in the prognostic value and immune characteristics by single‐cell and bulk sequencing analysis for liver hepatocellular carcinoma J. Gene Med. (IF 3.5) Pub Date : 2024-03-07 Qingqing Zhang, Bingye Zhu, Hongyan Yang, Fei Li, Ying Qu, Lungen Lu, Qidi Zhang
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SPINK5 inhibits esophageal squamous cell carcinoma metastasis via immune activity J. Gene Med. (IF 3.5) Pub Date : 2024-03-05 Jie Chen, Juncheng Lu, Zhiqiang Chen, Zihao Liu, Yuejun Sun, Shuyan He, Yedong Mi, Yi Gao, Dong Shen, Qingfeng Lin
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Issue Information J. Gene Med. (IF 3.5) Pub Date : 2024-02-27
No abstract is available for this article.
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JAM2 is a prognostic biomarker and inhibits proliferation, metastasis and epithelial–mesenchymal transition in lung adenocarcinoma J. Gene Med. (IF 3.5) Pub Date : 2024-02-26 Yanxin Dong, Jiale Zhang, Shun Xie, Shouyin Di, Boshi Fan, Taiqian Gong
BackgroundJunctional adhesion molecule 2 (JAM2) plays a pivotal role in various biological processes, including proliferation, metastasis and angiogenesis, contributing to tumor progression. While previous studies have highlighted the polarizing functions of JAM2 in different cancer types, its specific role in lung adenocarcinoma (LUAD) remains unclear.MethodsIn this study, we harnessed multiple public
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Development of a novel prognostic signature based on single‐cell combined bulk RNA analysis in breast cancer J. Gene Med. (IF 3.5) Pub Date : 2024-02-26 Ying Xiao, Ge Hu, Ning Xie, Liang Yin, Yaqiang Pan, Cong Liu, Shihan Lou, Cunzhi Zhu
BackgroundBreast cancer (BC), a malignant tumor, is a significant cause of death and disability among women globally. Recent research indicates that copy number variation plays a crucial role in tumor development. In this study, we employed the Single‐Cell Variational Aneuploidy Analysis (SCEVAN) algorithm to differentiate between malignant and non‐malignant cells, aiming to identify genetic signatures
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Global analysis of urinary extracellular vesicle small RNAs in autosomal dominant polycystic kidney disease J. Gene Med. (IF 3.5) Pub Date : 2024-02-26 Hamad Ali, Md. Zubbair Malik, Mohamed Abu‐Farha, Jehad Abubaker, Preethi Cherian, Rasheeba Nizam, Sindhu Jacob, Yousif Bahbahani, Medhat Naim, Sajjad Ahmad, Mohammad Al‐Sayegh, Thangavel Alphonse Thanaraj, Albert C. M. Ong, Peter C. Harris, Fahd Al‐Mulla
BackgroundAutosomal dominant polycystic kidney disease (ADPKD) is the most prevalent monogenic renal disease progressing to end‐stage renal disease. There is a pressing need for the identification of early ADPKD biomarkers to enable timely intervention and the development of effective therapeutic approaches. Here, we profiled human urinary extracellular vesicles small RNAs by small RNA sequencing in
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Circulating microvesicles miR139‐3p from bronchopulmonary dysplasia aggravates pulmonary vascular simplification by targeting 4E binding protein 1 J. Gene Med. (IF 3.5) Pub Date : 2024-02-23 Linchao Yu, Rui He, Chan Liu, Yuan Shi, Daoxin Wang
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Natural killer cell‐based signature: Prognostic analysis in head and neck squamous cell carcinoma J. Gene Med. (IF 3.5) Pub Date : 2024-02-22 Zizhao Guo, Yuxia Zhao, Meng Xu, Long Zhao, Xiaolei Wang
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Trends in the synthetic polymer delivery of RNA J. Gene Med. (IF 3.5) Pub Date : 2024-02-21 Josh J. Friesen, Anna K. Blakney
Ribonucleic acid (RNA) has emerged as one of the most promising therapeutic payloads in the field of gene therapy. There are many unique types of RNA that allow for a range of applications including vaccination, protein replacement therapy, autoimmune disease treatment, gene knockdown and gene editing. However, RNA triggers the host immune system, is vulnerable to degradation and has a low proclivity
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Zebrafish in understanding molecular pathophysiology, disease modeling, and developing effective treatments for Rett syndrome J. Gene Med. (IF 3.5) Pub Date : 2024-02-21 Subrata Pramanik, Asis Bala, Ajay Pradhan
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Baicalin induces ferroptosis in oral squamous cell carcinoma by suppressing the activity of FTH1 J. Gene Med. (IF 3.5) Pub Date : 2024-02-21 Zhihao Wen, Yuxiao Zhang, Bo Gao, Xin Chen
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Comparison of immune-related gene signatures and immune infiltration features in early- and late-onset preeclampsia J. Gene Med. (IF 3.5) Pub Date : 2024-02-16 Quanfeng Wu, Xiang Ying, Weiwei Yu, Huanxi Li, Wei Wei, Xueyan Lin, Meilin Yang, Xueqin Zhang
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The role of key biomarkers in lymphatic malformation: An updated review J. Gene Med. (IF 3.5) Pub Date : 2024-02-20 Mohammad Hadi Saeed Modaghegh, Hamid Tanzadehpanah, Mohammad Mahdi Kamyar, Hamed Manoochehri, Mohsen Sheykhhasan, Fatemeh Forouzanfar, Reihaneh Alsadat Mahmoudian, Elham Lotfian, Hanie Mahaki
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A Treg-related riskscore model may improve the prognosis evaluation of colorectal cancer J. Gene Med. (IF 3.5) Pub Date : 2024-02-11 Qingqing Li, Yuxin Chu, Yi Yao, Qibin Song
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Interaction of BANCR in the relationship between Hashimoto’s thyroiditis and papillary thyroid carcinoma expression patterns and possible molecular mechanisms J. Gene Med. (IF 3.5) Pub Date : 2024-02-11 Jiabo Zhang, Lingli Yao, Yu Guo
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Clinical and prognostic significance analysis of glycolysis-related genes in HNSCC J. Gene Med. (IF 3.5) Pub Date : 2024-02-09 Qiuyun Yuan, Mengqian Mao, Xiaoqiang Xia, Wanchun Yang
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Characterization of the m6A/m1A/m5C/m7G-related regulators on the prognosis and immune microenvironment of glioma by integrated analysis of scRNA-seq and bulk RNA-seq data J. Gene Med. (IF 3.5) Pub Date : 2024-02-06 Longkun Yang, Zhicong Huang, Ying Deng, Xing Zhang, Zhonghua Lv, Hao Huang, Qian Sun, Hui Liu, Hongsheng Liang, Baochang He, Fulan Hu
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Lnc00113 promotes triple-negative breast cancer progression via the NOB-1/MAPK signaling axis J. Gene Med. (IF 3.5) Pub Date : 2024-02-01 Xiaoyu Li, Yunjie Jin, Jianwei Huang, Chu Feng, Xi Chen, Liang Zuo, Guyue Liu, Fei Chen, Jiashu Fan, Lin Fang
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Issue Information J. Gene Med. (IF 3.5) Pub Date : 2024-01-30
No abstract is available for this article.
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Single-cell RNA sequencing reveals the mechanism of PI3K/AKT/mTOR signaling pathway activation in lung adenocarcinoma by KRAS mutation J. Gene Med. (IF 3.5) Pub Date : 2024-01-25 Long Xu, Renquan Ding, Shuxi Song, Junling Liu, Jingyu Li, Xing Ju, Baozhao Ju
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Actin filament-associated protein 1-antisense RNA1 promotes the development and invasion of tongue squamous cell carcinoma via the AFAP1-AS1/miR-133a-5p/ZIC2 axis J. Gene Med. (IF 3.5) Pub Date : 2024-01-21 Mingming Tang, Hao Wu, Huaiqin Zhang, Xinjiang Xu, Bin Jiang, Qingwen Chen, Yingze Wei, Hongyan Qian, Liang Han
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Constructing a personalized prognostic risk model for colorectal cancer using machine learning and multi-omics approach based on epithelial–mesenchymal transition-related genes J. Gene Med. (IF 3.5) Pub Date : 2024-01-16 Shuze Zhang, Wanli Fan, Dong He
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Identification and validation of non-coding RNA-mediated high expression of IQGAP3 in poor prognosis of lung adenocarcinoma J. Gene Med. (IF 3.5) Pub Date : 2024-01-16 Ziwei Su, Yang Wang, Jialing Cao, Jie Ma, Guangzhao Wang, Huijuan Ren, Yihan Zhang, Kangliang Sheng, Xueying Zhu, Yongzhong Wang
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BRIX1 promotes ribosome synthesis and enhances glycolysis by selected translation of GLUT1 in colorectal cancer J. Gene Med. (IF 3.5) Pub Date : 2024-01-16 Chunhui Jiang, Longci Sun, Siyuan Wen, Yuan Tian, Chunjie Xu, Qing Xu, Hanbing Xue
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AKT/FOXM1/STMN1 signaling pathway activation by SMC1A promotes tumor growth in breast cancer J. Gene Med. (IF 3.5) Pub Date : 2024-01-15 Kaichun Li, Ping Dai, Jian Li, Long Liu, Shiyu Cheng, Qingliang Fang, Bingxiang Wu
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miR-451a suppresses the proliferation and migration of high-grade serous ovarian cancer by targeting RAB5A through the Ras/Raf/MEK/ERK pathway J. Gene Med. (IF 3.5) Pub Date : 2024-01-15 Shujie Liu, Kun Wang, Zhendan Zhao, Yu Pang, Fang Liu, Pengling Wang, Zhiling Wang, Xingsheng Yang
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Unveiling Anoikis-related genes: A breakthrough in the prognosis of bladder cancer J. Gene Med. (IF 3.5) Pub Date : 2024-01-11 Shen Jiang, Xiping Yang, Yang Lin, Yunfei Liu, Lisa Jia Tran, Jing Zhang, Chengjun Qiu, Fangdie Ye, Zhou Sun
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Prognosis and therapy in thyroid cancer by gene signatures related to natural killer cells J. Gene Med. (IF 3.5) Pub Date : 2024-01-09 Zhen Jin, Yadong Han, Jiaxin Zhang, Zhao Liu, Ran Li, Zhao Liu
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Genome-wide polygenic risk score for rheumatoid arthritis prediction in postmenopausal women J. Gene Med. (IF 3.5) Pub Date : 2024-01-08 Yingke Xu, Qing Wu
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Relevance of pyroptosis-associated genes in nasopharyngeal carcinoma diagnosis and subtype classification J. Gene Med. (IF 3.5) Pub Date : 2024-01-08 Yan Wang, Yuxia Zou, Xianghui Chen, Xiaoyan Wang, Hao Zheng, Qing Ye
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Autophagy-related risk signature based on CDNK2A to facilitate survival prediction of patients with endometrial cancer J. Gene Med. (IF 3.5) Pub Date : 2024-01-06 Chaomin Yue, Baohua Lin, Xiang Sun, Xindi Xu, Chufan Zhou, Jiaying Fan
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Exploration of the prognostic effect of costimulatory genes in bladder cancer J. Gene Med. (IF 3.5) Pub Date : 2024-01-06 Hao Su, Ziqi Liu, Chaoyue Zhang, Zebin Deng, Xiaozhe Su, Yinhuai Wang, Wentao Liu
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Issue Information J. Gene Med. (IF 3.5) Pub Date : 2024-01-04
No abstract is available for this article.
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Construction and validation of molecular subtype and signature of immune cell-related telomeric genes and prediction of prognosis and immunotherapy efficacy in ovarian cancer patients J. Gene Med. (IF 3.5) Pub Date : 2024-01-06 Lele Ling, Bingrong Li, Huijing Wu, Kaiyong Zhang, Siwen Li, Boliang Ke, Zhengyang Zhu, Te Liu, Peng Liu, Bimeng Zhang
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MiR-431 promotes cardiomyocyte proliferation by targeting FBXO32 expression J. Gene Med. (IF 3.5) Pub Date : 2024-01-06 Mengsha Li, Chenrui Zhang, Lirong Tan, Tingyan Liu, Tingting Zhu, Xuejiao Wei, Jiacai Liu, Xiaoyun Si, Bing Li
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Implantation of human urine stem cells promotes neural repair in spinal cord injury rats associated cadeharin-1 and integrin subunit beta 1 expression J. Gene Med. (IF 3.5) Pub Date : 2023-12-20 Ji-Lin Chen, Na Li, Min Xu, Lei Wang, Jie Sun, Li Liu, Yu-Fei Wang, Bao-Lei Zhang, Hai-Yang Suo, Ting-Hua Wang, Fang Wang
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Featured Cover J. Gene Med. (IF 3.5) Pub Date : 2023-12-18 Yuka Hayashi, Yoshihide Sehara, Ryota Watano, Kenji Ohba, Yuki Takayanagi, Kazuhiro Muramatsu, Yoshio Sakiyama, Hiroaki Mizukami
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Issue Information J. Gene Med. (IF 3.5) Pub Date : 2023-12-18
No abstract is available for this article.
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Necrotizing apoptosis-related genes prognosis and treatment effect analysis of osteosarcoma in children J. Gene Med. (IF 3.5) Pub Date : 2023-12-15 Yuanling Chen, Ling Wu, Yunyan Li, Jika Zheng, Shiling Zhong, Shirong Gu, Jingyang Chen
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Identification of prognostic value of anoikis-related gene score model combined with tumor microenvironment score models in esophageal squamous cell carcinoma J. Gene Med. (IF 3.5) Pub Date : 2023-12-13 Moyan Zhang, Yicheng Liang, Peng Song
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Amino acids and their roles in tumor immunotherapy of breast cancer J. Gene Med. (IF 3.5) Pub Date : 2023-12-12 Hongzhuo Xia, Jianyu Zhu, Zhuomeng Zheng, Peiyao Xiao, Xiaohui Yu, Muyao Wu, Lian Xue, Xi Xu, Xinyu Wang, Yuxuan Guo, Chanjuan Zheng, Siyu Ding, Yian Wang, Xiaoning Peng, Shujun Fu, Junjun Li, Xiyun Deng
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HGF facilitates methylation of MEG3, potentially implicated in vemurafenib resistance in melanoma J. Gene Med. (IF 3.5) Pub Date : 2023-12-10 Xiaomin Jia, Hao Feng, Shan He, Xiao Chen, Hao Feng, Mingliang Chen, Xing Hu
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Activation of toll-like receptor 4/nuclear factor-kappa B signaling by triggering a receptor expressed on myeloid cells 1 promotes alveolar macrophage M1 polarization and exacerbates septic acute lung injury J. Gene Med. (IF 3.5) Pub Date : 2023-12-07 Qingwu Liao, Xiaojuan Su, Zhengang Tao, Zheng Li, Huilin Wang, Ying Yuan
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Identification and exploration of aging-related subtypes and distinctive role of SERPINE1 in heart failure based on single-cell and bulk RNA sequencing data J. Gene Med. (IF 3.5) Pub Date : 2023-12-07 Shengnan Li, Fanliang Kong, Xuan Xu, Sifan Song, Yandan Wu, Jiayi Tong
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Akkermansia muciniphila might improve anti-PD-1 therapy against HCC by changing host bile acid metabolism J. Gene Med. (IF 3.5) Pub Date : 2023-12-07 Xiucai Lan, Jiaming Ma, Zhipeng Huang, Yuzhen Xu, Yaomin Hu
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Disulfidptosis-related PABPC3 promotes tumor progression and inhibits immune activity in osteosarcoma J. Gene Med. (IF 3.5) Pub Date : 2023-12-07 Yangbo Cao, Song Wu, Yishan Gu, Yung Hou Wong, Yanbin Shi, Lina Zhang
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MicroRNA-299-3p inhibits cell proliferation, motility, invasion and angiogenesis via VEGFA in upper tract urothelial carcinoma J. Gene Med. (IF 3.5) Pub Date : 2023-12-04 Chien-Shen Wang, Yi-Chen Lee, Jhen-Hao Jhan, Wei-Ming Li, Lin-Li Chang, A-Mei Huang, Hui-Hui Lin, Yi-Ru Wu, Wei-Chi Hsu, Hung-Lung Ke
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Identification of prognostic biomarkers for cervical cancer based on programmed cell death-related genes and assessment of their immune profile and response to drug therapy J. Gene Med. (IF 3.5) Pub Date : 2023-12-04 Sijie Feng, Zhenhui Wang, Huizhen Zhang, Baohua Hou, Yanjun Xu, Shuangying Hao, Yunkun Lu
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Surface modification of lipid nanoparticles for gene therapy J. Gene Med. (IF 3.5) Pub Date : 2023-12-03 Belal Tafech, Fatemeh Mohabatpour, Sarah Hedtrich
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Novel molecular insights into pyroptosis in triple-negative breast cancer prognosis and immunotherapy J. Gene Med. (IF 3.5) Pub Date : 2023-12-02 Bin Yu, Junjie Luo, Yifei Yang, Ke Zhen, Binjie Shen
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Shikonin potentiates skin wound healing in Sprague–Dawley rats by stimulating fibroblast and endothelial cell proliferation and angiogenesis J. Gene Med. (IF 3.5) Pub Date : 2023-11-28 Chenhong Xue, Jinfa Dou, Shuzhen Zhang, Huiqian Yu, Shoumin Zhang
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Prognostic evaluation of the novel blueprint of DNA methylation sites by integrating bulk RNA-sequencing and methylation modification data in endometrial cancer J. Gene Med. (IF 3.5) Pub Date : 2023-11-27 Huanzhen Zhou, Yingzhi Zhang, Jing Jin, Kewei Shen, Yang Yang, Peiwei Lao
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Long non-coding RNA linc00659 promotes tumour progression by regulating FZD6/Wnt/β-catenin signalling pathway in colorectal cancer via m6A reader IGF2BP1 J. Gene Med. (IF 3.5) Pub Date : 2023-11-27 Shufen Xu, Zichun Liu, Qian Luo, Lisha Chang, Jie Ding, Yanan Xiao, Yangyang Zhang, Guoren Zhou, Keming Wang
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Homologous recombination deficiency reflects the heterogeneity and monitoring treatment response for patients with breast cancer J. Gene Med. (IF 3.5) Pub Date : 2023-11-23 Quanyi Long, Yunfei Wang, Hongjiang Li
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Multiomics blueprint of PANoptosis in deciphering immune characteristics and prognosis stratification of glioma patients J. Gene Med. (IF 3.5) Pub Date : 2023-11-23 Maohua Chen, Min Huang, Xiaoxiang Chen, Xiaoyu Lin, Xianglin Chen
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Reducing the transcriptional read-through rate of a lentiviral vector for β-thalassemia gene therapy J. Gene Med. (IF 3.5) Pub Date : 2023-11-21 Jiahui Wu, Yuan Chen, Wenchen Shen, Jingzhi Zhang, Fanyi Zeng
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Bioinformatics analysis of the prognosis and biological significance of N6 methyladenine regulators in oral squamous cell carcinoma J. Gene Med. (IF 3.5) Pub Date : 2023-11-20 Mei Yu, Fang Shen, Xiuxian Li, Chuandong Zhu, Yaoyao Pei, Manli Zhang, Wei Xiao