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A Psychometric Evaluation of the Dysphagia Handicap Index Using Rasch Analysis J. Clin. Med. (IF 3.9) Pub Date : 2024-04-17 Reinie Cordier, Annette Veronica Joosten, Bas J. Heijnen, Renée Speyer
Background/Objectives: The Dysphagia Handicap Index (DHI) is commonly used in oropharyngeal dysphagia (OD) research as a self-report measure of functional health status and health-related quality of life. The DHI was developed and validated using classic test theory. The aim of this study was to use item response theory (Rasch analysis) to evaluate the psychometric properties of the DHI. Methods: Prospective
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MRI-Based Radiomics as a Promising Noninvasive Diagnostic Technique for Adenomyosis J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Laurin Burla, Elisabeth Sartoretti, Manoj Mannil, Stefan Seidel, Thomas Sartoretti, Harald Krentel, Rudy Leon De Wilde, Patrick Imesch
Background: MRI diagnostics are important for adenomyosis, especially in cases with inconclusive ultrasound. This study assessed the potential of MRI-based radiomics as a novel tool for differentiating between uteri with and without adenomyosis. Methods: This retrospective proof-of-principle single-center study included nine patients with and six patients without adenomyosis. All patients had preoperative
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Novel Parameter in Pre-Surgical Orthodontic Preparation: A Retrospective Study on the Role of the Upper Incisor Position and a Morphological Evaluation of the Anterior Nasal Spine J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Ornella Rossi, Giovanna Perrotti, Massimo Del Fabbro, Tiziano Testori
The position and inclination of the incisors play a crucial role in achieving optimal outcomes in orthodontic and orthognathic surgical treatment, given their impact on facial aesthetics. Background/objectives: Due to numerous distorting factors that affect the reliability of the ANB angle, the aim of the present work is to evaluate a more constant parameter over time, the anterior nasal spine (ANS)
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The Depth of the Molecular Response in Patients with Chronic Myeloid Leukemia Correlates with Changes in Humoral Immunity J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Michał Janowski, Karolina Łuczkowska, Michał Gniot, Krzysztof Lewandowski, Krzysztof Safranow, Grzegorz Helbig, Bogusław Machaliński, Edyta Paczkowska
Background and Objectives: The effective treatment of chronic myeloid leukemia leads to the restoration of proper immune system function. We aimed to investigate fluctuations in circulating cytokines, angiogenic factors and complement components in patients with CML during the first year of treatment with TKI and correlate them with the degree of achieved molecular response. Material and Methods: We
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Exploring Chronic Hypocalcemia: Insights into Autoimmune Polyglandular Syndrome Type 1—A Case Study and Literature Review J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Giorgiana-Flavia Brad, Delia-Maria Nicoară, Alexandra-Cristina Scutca, Meda-Ada Bugi, Raluca Asproniu, Laura-Gratiela Olariu, Iulius Jugănaru, Lucian-Ioan Cristun, Otilia Mărginean
Hypocalcemia is a common occurrence in pediatric patients, attributed to various causes and presenting with diverse clinical manifestations. A prompt evaluation is necessary to determine its underlying cause, whether it presents acutely or chronically, and to tailor treatment based on its severity. Among the potential causes of chronic hypocalcemia, primary hypoparathyroidism stands out. The case of
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Comparisons of Two Different Treatment Methods for Impacted Maxillary Canines: A Retrospective Study J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Anita Fekonja
Background: The impaction of the maxillary canine is a common occurrence, and orthodontists must be prepared to manage it. The purpose of this article is to present a study of the efficacy of a double-wire orthodontic appliance compared to a control group in the alignment of impacted maxillary canines in the dental arch. Methods: To diagnose an impacted maxillary canine, a panoramic radiograph was
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The Obesity Mortality Paradox in Patients with Pulmonary Embolism: Insights from a Tertiary Care Center J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Fahad Alkhalfan, Syed Bukhari, Akiva Rosenzveig, Rohitha Moudgal, Syed Zamrak Khan, Mohamed Ghoweba, Pulkit Chaudhury, Scott J. Cameron, Leben Tefera
Background: While obesity is associated with an increased risk of venous thromboembolism (VTE), there is some data to suggest that higher BMI is also associated with decreased all-cause mortality in patients with a pulmonary embolism (PE). Methods: Using PE Response Team (PERT) activation data from a large tertiary hospital between 27 October 2020 and 28 August 2023, we constructed a multivariate Cox
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Current Management of In-Stent Restenosis J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Daniele Giacoppo, Placido Maria Mazzone, Davide Capodanno
In-stent restenosis (ISR) remains the primary cause of target lesion failure following percutaneous coronary intervention (PCI), resulting in 10-year incidences of target lesion revascularization at a rate of approximately 20%. The treatment of ISR is challenging due to its inherent propensity for recurrence and varying susceptibility to available strategies, influenced by a complex interplay between
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Topographic Keratoconus Incidence in Greece Diagnosed in Routine Consecutive Cataract Procedures: A Consecutive Case Series of 1250 Cases over 5 Years J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Anastasios John Kanellopoulos, Alexander J. Kanellopoulos
Background: Scheimpflug tomography has for many years been an integral part of our pre-operative assessment in cataract extraction. We retrospectively reviewed the incidence of topographic keratoconus and keratoconus suspicion in our routine cataract surgery population over 5 years. Setting: The Laservision Clinical and Research Institute, Athens, Greece. Methods: In 1250 consecutive cataract surgery
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Maternal–Fetal Compatibility in Recurrent Pregnancy Loss J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Isabel Cuadrado-Torroglosa, Juan A. García-Velasco, Diana Alecsandru
Nowadays, recurrent pregnancy loss (RPL) is an undesirable condition suffered by many patients of reproductive age. In this scenario, certain immune cell populations and molecules, involved in maternal–fetal compatibility, have emerged as factors related with the pathogenesis of RPL. Among them, uterine Natural Killer cells (uNKs) appear to be of great relevance. These cells are involved in numerous
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Linezolid-Associated Thrombocytopenia: Assessment of Risk Factors in Patients without Hemato-Oncologic Diseases J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Abrar K. Thabit, Arwa A. Alghamdi, Afnan K. Alsaeed, Nesreen M. Magbool, Yazed S. Alsowaida, Ahmad J. Mahrous, Alya Alruwaili, Ziyad K. Albakistani, Basem O. Albangali, Anas M. Alghumuy, Sara A. Youssef, Reem M. Alodayli, Masaad Saeed Almutairi
Background: Linezolid is used for Gram-positive bacterial infections. Thrombocytopenia is one of its main adverse effects resulting from myelosuppression. Several studies have assessed risk factors that may increase the risk of this adverse effect. However, most studies included patients with hemato-oncologic diseases, which may confound such assessments. This study aimed to investigate risk factors
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Factors Associated with Frailty in Older Adults in Community and Nursing Home Settings: A Systematic Review with a Meta-Analysis J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Jia Liu, Yuezhi Zhu, Jen Kit Tan, Azera Hasra Ismail, Roszita Ibrahim, Nor Haty Hassan
Background: Frailty is a globally recognized issue. However, there is a lack of evidence exploring factors associated with frailty among older residents in community and nursing-home settings. Methods: To explore the prevalence and factors associated with frailty among older adults in community and nursing-home settings, we conducted a systematic search following the PRISMA guidelines across Web of
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Immunomodulatory Effect of COVID-19 on HLA-Antibody Profile in Renal Transplant Recipients J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Marina Kljajic, Zoran Sabljic, Ivana Juric, Vesna Furic Cunko, Renata Zunec, Marija Burek Kamenaric, Bojan Jelakovic, Nikolina Basic-Jukic
Background/Objectives: The novel coronavirus disease 2019 (COVID-19) has led to significant morbidity and mortality among kidney transplant recipients. SARS-CoV-2 has been hypothesized to cause an unusual immunological dysregulation triggering alloimmunity and leading to graft rejection. Methods: This prospective observational cohort study assessed 321 kidney transplant recipients who had COVID-19
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Catheter Ablation for Channelopathies: When Is Less More? J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Adhya Mehta, Rishi Chandiramani, Binita Ghosh, Babken Asatryan, Adrija Hajra, Andreas S. Barth
Ventricular fibrillation (VF) is a common cause of sudden cardiac death in patients with channelopathies, particularly in the young population. Although pharmacological treatment, cardiac sympathectomy, and implantable cardioverter defibrillators (ICD) have been the mainstay in the management of VF in patients with channelopathies, they are associated with significant adverse effects and complications
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Trace Elements in Alzheimer’s Disease and Dementia: The Current State of Knowledge J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Magdalena Tyczyńska, Marta Gędek, Adam Brachet, Wojciech Stręk, Jolanta Flieger, Grzegorz Teresiński, Jacek Baj
Changes in trace element concentrations are being wildly considered when it comes to neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease. This study aims to present the role that trace elements play in the central nervous system. Moreover, we reviewed the mechanisms involved in their neurotoxicity. Low zinc concentrations, as well as high levels of copper, manganese, and
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Quantification of Aortic Valve Calcification in Contrast-Enhanced Computed Tomography J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Danai Laohachewin, Philipp Ruile, Philipp Breitbart, Jan Minners, Nikolaus Jander, Martin Soschynski, Christopher L. Schlett, Franz-Josef Neumann, Dirk Westermann, Manuel Hein
Background: The goal of our study is to evaluate a method to quantify aortic valve calcification (AVC) in contrast-enhanced computed tomography for patients with suspected severe aortic stenosis pre-interventionally. Methods: A total of sixty-five patients with aortic stenosis underwent both a native and a contrast-enhanced computed tomography (CECT) scan of the aortic valve (45 in the training cohort
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Influence of STAT4 Genetic Variants and Serum Levels on Multiple Sclerosis Occurrence in the Lithuanian Population J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Akvile Bruzaite, Greta Gedvilaite, Renata Balnyte, Loresa Kriauciuniene, Rasa Liutkeviciene
Background: Multiple sclerosis (MS) is an autoimmune disease involving demyelination, inflammation, gliosis, and the loss of neurons. MS is a growing global health problem most likely caused by genetic, immunological, and environmental factors. However, the exact etiology of the disease is still unknown. Since MS is related to a dysregulation of the immune system, it could be linked to signal transducer
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Innovative Non-Surgical Plastic Technique for Saddle Nose Correction: A Study on 97 Patients J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Riccardo Ossanna, Sara Ghazanfar Tehrani, Alessia Dallatana, Sima Khabouri, Sheila Veronese, Andrea Sbarbati, Mario Goisis
Background: Non-surgical rhinoplasty is one of the best choices in mild cases of the saddle nose, and it represents a solution for the aesthetical amelioration of facial deformity; nevertheless, in most critical cases, surgical intervention is still required. This study reports the experience and results of a single facial plastic surgeon (M.G.) using a non-surgical technique for the correction of
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The Use of Fish Skin Grafts in Children as a New Treatment of Deep Dermal Burns—Case Series with Follow-Up after 2 Years and Measurement of Elasticity as an Objective Scar Evaluation J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Raphael Staubach, Helen Glosse, Steffan Loff
Background: Wound healing in deep dermal burn injuries continues to be a challenge in paediatrics. In the absence quick and spontaneous wound closure, split-thickness skin grafting is often necessary. Since the development of a new type of acellular fish matrix, which is very similar to the human skin matrix, skin closure and wound conditioning can be achieved without split-thickness skin grafting
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Neutrophil Extracellular Traps and Respiratory Disease J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Paul T. King, Lovisa Dousha
Extracellular traps made by neutrophils (NETs) and other leukocytes such as macrophages and eosinophils have a key role in the initial immune response to infection but are highly inflammatory and may contribute to tissue damage. They are particularly relevant to lung disease, with the pulmonary anatomy facilitating their ability to fully extend into the airways/alveolar space. There has been a rapid
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Primary Coenzyme Q10 Deficiency-Related Ataxias J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Piervito Lopriore, Marco Vista, Alessandra Tessa, Martina Giuntini, Elena Caldarazzo Ienco, Michelangelo Mancuso, Gabriele Siciliano, Filippo Maria Santorelli, Daniele Orsucci
Cerebellar ataxia is a neurological syndrome characterized by the imbalance (e.g., truncal ataxia, gait ataxia) and incoordination of limbs while executing a task (dysmetria), caused by the dysfunction of the cerebellum or its connections. It is frequently associated with other signs of cerebellar dysfunction, including abnormal eye movements, dysmetria, kinetic tremor, dysarthria, and/or dysphagia
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Intraoperative Fracture during the Insertion of Advanced Locking Screws (T2 Alpha Femur Retrograde Intramedullary Nailing System): Report of Two Cases and Identifying Causes and Prevention J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Takashi Higuchi, Atsushi Taninaka, Rikuto Yoshimizu, Katsuhiro Hayashi, Shinji Miwa, Norio Yamamoto, Hiroyuki Tsuchiya, Satoru Demura
Background: Recently, the T2 alpha nailing system (Stryker, Inc.), which has advanced locking screws that can attach a screw to a rod, has been used worldwide and is expected to improve fracture fixation. We analyzed two cases of supracondylar femoral fractures in older adult patients, in which intraoperative fractures occurred during the insertion of advanced locking screws of the T2 alpha femur retrograde
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Long-Term Efficacy and Safety of Direct Oral Anticoagulants at Reduced Doses in the Secondary Prevention of Venous Thromboembolism and Post-Thrombotic Syndrome J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Luca Costanzo, Federico Di Paola, Anastasia Maria Pedi, Giacomo Failla, Marco Mangiafico
Background: Anticoagulation for venous thromboembolism (VTE) is required for at least three to six months; however, it is advisable to extend the duration in certain cases, in which case a reduced dose of Direct Oral Anticoagulants (DOACs) may be an option. Our objective was to investigate the efficacy and safety of reduced-dose DOACs in extended anticoagulation treatment compared to full doses. Methods
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The Association of Desert Dust with the Risk of Acute Coronary Syndrome in Subjects of a Younger Age J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Alberto Domínguez-Rodríguez, Néstor Baéz-Ferrer, Pablo Avanzas, Sergio Rodríguez, Pedro Abreu-González, Elisa Trujillo-Martin, Guillermo Burillo-Putze, Daniel Hernández-Vaquero
Objectives: Recently, desert dust in Europe has been recognized as a cardiovascular health problem. In Spain, desert dust inflows in recent years have been associated with worsening air quality. The present study examines whether desert dust events are related to the incidence of acute coronary syndrome (ACS) in patients under 55 years of age. Methods: Data from 2416 consecutive patients admitted to
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Nursing Interventions to Prevent Secondary Injury in Critically Ill Patients with Traumatic Brain Injury: A Scoping Review J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Rita Figueiredo, Cidália Castro, Júlio Belo Fernandes
Traumatic brain injury is a prevalent health issue with significant social and economic impacts. Nursing interventions are crucial in preventing secondary injury and improving patient prognosis. This scoping seeks to map and analyze the existing scientific evidence on nursing interventions aimed at preventing secondary injuries in critically ill patients with traumatic brain injury. Methods: The review
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The Influence of Inset and Shaping of Abdominal-Based Free Flap Breast Reconstruction on Patient-Reported Aesthetic Outcome Scores—A Systematic Review J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Isabel Zucal, Laura De Pellegrin, Corrado Parodi, Yves Harder, Riccardo Schweizer
Background: Nowadays, multimodal cancer therapy results in very high survival rates of early-stage breast cancer and microsurgical flap-based breast reconstruction has become safe and reliable, with gradually increasing demand because of its durable and aesthetically pleasing results. This study aimed to explore the impact of different flap shaping and inset techniques on patient-reported outcome measures
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PlasmaBlade versus Electrocautery for Deep Inferior Epigastric Perforator Flap Harvesting in Autologous Breast Reconstruction: A Comparative Clinical Outcome Study J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Angela Augustin, Ines Schoberleitner, Sophie-Marie Unterhumer, Johanna Krapf, Thomas Bauer, Dolores Wolfram
(1) Background: DIEP-based breast reconstruction necessitates wide undermining at the abdominal donor site, creating large wound areas. Flap harvesting is usually conducted using electrosurgical dissection devices. This study sought to compare the clinical outcomes in patients after using the PEAK PlasmaBlade (PPB) versus monopolar electrocautery (MPE). (2) Methods: This retrospective cohort study
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A Nomogram for Predicting ADHD and ASD in Child and Adolescent Mental Health Services (CAMHS) J. Clin. Med. (IF 3.9) Pub Date : 2024-04-19 Hilario Blasco-Fontecilla, Chao Li, Miguel Vizcaino, Roberto Fernández-Fernández, Ana Royuela, Marcos Bella-Fernández
Objectives: To enhance the early detection of Attention Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) by leveraging clinical variables collected at child and adolescent mental health services (CAMHS). Methods: This study included children diagnosed with ADHD and/or ASD (n = 857). Three logistic regression models were developed to predict the presence of ADHD, its subtypes
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The Potential Role of Presepsin in Predicting Severe Infection in Patients with Diabetic Foot Ulcers J. Clin. Med. (IF 3.9) Pub Date : 2024-04-17 Eun Yeong Ha, Il Rae Park, Seung Min Chung, Young Nam Roh, Chul Hyun Park, Tae-Gon Kim, Woong Kim, Jun Sung Moon
Background/Objectives: Diabetic foot ulcers are one of the complications in patients with diabetes, which can be caused by infection, neuropathy, and blood vessel disorder. Among them, infection is the most common cause, and if it becomes worse, amputation may be necessary. So, it is important to detect and treat infections early, and determining indicators that can confirm infection is also important
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Thicker Inner Nuclear Layer as a Predictor of Glaucoma Progression and the Impact of Intraocular Pressure Fluctuation J. Clin. Med. (IF 3.9) Pub Date : 2024-04-17 Kyoung In Jung, Hee Kyung Ryu, Si Eun Oh, Hee Jong Shin, Chan Kee Park
Background: Thickening of the inner nuclear layer (INL) or microcystic macular changes has been reported to be implicated in glaucoma patients, but their potential impact on disease progression remains unclear. We investigated the relationship between baseline microcystic macular edema in the INL or INL thickness and subsequent visual field (VF) progression in glaucoma patients. Methods: This retrospective
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The Impact of Augmented Renal Clearance on Vancomycin Pharmacokinetics and Pharmacodynamics in Critically Ill Patients J. Clin. Med. (IF 3.9) Pub Date : 2024-04-17 Novel Solomon Tesfamariam, Asma Aboelezz, Sherif Hanafy Mahmoud
Augmented renal clearance (ARC), defined as a creatinine clearance (CrCl) > 130 mL/min/1.73 m2, is observed in 30–65% of critically ill patients. When following standard dosage guidelines, patients with ARC often experience subtherapeutic vancomycin levels, resulting in treatment failure due to accelerated drug elimination. This review aims to explore ARC’s impact on vancomycin pharmacokinetics and
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Exercise-Induced Troponin Elevation in High-Performance Cross-Country Skiers J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Tom Kastner, Florian Frohberg, Judith Hesse, Bernd Wolfarth, Jan C. Wuestenfeld
Background: Troponin I and T are biomarkers to diagnose myocardial infarction and damage. Studies indicate that strenuous physical activity can cause transient increases in these troponin levels, typically considered physiological. However, current data show differences in the exercise-induced increase in troponin I and T in elite athletes. Method: This prospective clinical study aimed to determine
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Sonography as a Diagnostic Tool in Midurethral Sling Complications: A Narrative Review J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Aneta Zwierzchowska, Paweł Tomasik, Edyta Horosz, Ewa Barcz
Despite the established safety and efficacy of midurethral slings (MUS), which are the current gold standard treatment for stress urinary incontinence (SUI), the potential for postoperative complications remains a significant concern for both healthcare professionals and patients. Meanwhile, sonography has emerged as a significant diagnostic tool in urogynecology, and one of the applications of this
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The Chronological Evolution of Cochlear Implant Contraindications: A Comprehensive Review J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Nezar Hamed, Norah Alajmi, Faisal Ibrahim Alkoblan, Yazeed Abdullah Alghtani, Yassin Abdelsamad, Ahmed Alhussien, Rafeef Ibrahim Alhajress, Salman F. Alhabib
Cochlear implantation has emerged as a transformative intervention in addressing profound hearing loss, offering a paradigm shift in auditory rehabilitation for individuals with restricted auditory function. Throughout its history, the understanding of contraindications for cochlear implant (CI) surgery has evolved significantly. This review comprehensively analyzes the chronological advancements in
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Ivabradine in Septic Shock: A Narrative Review J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Marco Pasetto, Lorenzo Antonino Calabrò, Filippo Annoni, Sabino Scolletta, Vincent Labbé, Katia Donadello, Fabio Silvio Taccone
In patients with septic shock, compensatory tachycardia initially serves to maintain adequate cardiac output and tissue oxygenation but may persist despite appropriate fluid and vasopressor resuscitation. This sustained elevation in heart rate and altered heart rate variability, indicative of autonomic dysfunction, is a well-established independent predictor of adverse outcomes in critical illness
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Urinary Biomarkers for Lupus Nephritis: A Systems Biology Approach J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Mohamed H. Omer, Areez Shafqat, Omar Ahmad, Juzer Nadri, Khaled AlKattan, Ahmed Yaqinuddin
Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disorder. Kidney involvement, termed lupus nephritis (LN), is seen in 40–60% of patients with systemic lupus erythematosus (SLE). After the diagnosis, serial measurement of proteinuria is the most common method of monitoring treatment response and progression. However, present treatments for LN—corticosteroids and immunosuppressants—target
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The Day After: The Longitudinal Effect of COVID-19 Lockdown on Quality of Life of University Students and the Moderator Role of Mindfulness J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Pamela Barone, Carmen Borrás-Sansaloni, Marina Ricco-Pérez, Emilio López-Navarro, Capilla Navarro-Guzmán
Background: The COVID-19 lockdown has been a major stressor for the general population, posing a considerable threat to quality of life (QoL), particularly among university students. Existing research highlights the protective role of dispositional mindfulness (DM) in mitigating stressors; however, its influence on moderating the impact of COVID-19 on QoL remains unknown. We used a longitudinal design
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Glenohumeral Osteoarthritis: A Biological Advantage or a Missed Diagnosis? J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Camille Crane, Caleb Wagner, Stephen Wong, Bryce Hall, Jillian Hull, Katharine Irwin, Kaitlin Williams, Amanda Brooks
(1) Background: Osteoarthritis is a degenerative joint disease that is commonly diagnosed in the aging population. Interestingly, the lower extremity joints have a higher published incidence of osteoarthritis than the upper extremity joints. Although much is known about the disease process, it remains unclear why some joints are more affected than others. (2) Methods: A comprehensive literature review
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Detraining among Athletes—Is Withdrawal of Adaptive Cardiovascular Changes a Hint for the Differential Diagnosis of Physically Active People? J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Kinga Zujko-Kowalska, Karol Adam Kamiński, Łukasz Małek
An athlete’s training aims to achieve the highest possible sports results by improving physical dispositions which lead to cardiac adaptive changes. The annual training cycle is divided into periods. The preparatory period begins with gradually increasing training intensity and volume until the competitive period occurs, when the athlete’s maximum performance is expected. Finally, the athlete enters
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Osteoprotegerin and Inflammation in Incident Peritoneal Dialysis Patients J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Michał Małecki, Patrycja Okulewicz, Marcin Lisak, Krzysztof Safranow, Leszek Domański, Kazimierz Ciechanowski, Edyta Gołembiewska
Objectives: Osteoprotegerin (OPG) is a member of the tumor necrosis factor receptor family involved in processes in many inflammatory states. OPG concentration is enhanced in the majority of chronic kidney disease (CKD) patients and those undergoing renal replacement therapy. The aim of the study was to assess the relation of OPG and chronic inflammation in peritoneal dialysis (PD) patients and to
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Elevated Colon Cancer Rates Linked to Prior Appendicitis: A Retrospective Cohort Study Based on Data from German General Practices J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Susann Steffes, Karel Kostev, Jörn M. Schattenberg, Hauke S. Heinzow, Miriam Maschmeier
Background/Objective: The association between appendicitis and colon cancer is not yet fully understood. Previous studies have shown contradictory results. Currently, no population-based data from Germany are available with regard to the incidence of colon cancer following appendicitis. This study investigated the association between appendicitis and the incidence of colon cancer in Germany. Methods:
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Risk Factors for Non-Adherence to Medication for Liver Transplant Patients: An Umbrella Review J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Jordi Colmenero, Mikel Gastaca, Laura Martínez-Alarcón, Cristina Soria, Esther Lázaro, Inmaculada Plasencia
Background/Objectives: Liver Transplantation (LT) is the second most common solid organ transplantation. Medication adherence on LT patients is key to avoiding graft failure, mortality, and important quality of life losses. The aim of this study is to identify risk-factors for non-adherence to treatment of liver transplant patients according to reliable published evidence. Methods: An umbrella review
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Comparison between Discrete Multi-Wavelength Near-Infrared Spectroscopy and Bioelectrical Impedance Analysis in the Assessment of Muscle Mass for Community-Dwelling Older People J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Jinyoung Shin, Eunki Park
(1) Background: This study evaluated the clinical implications of a new measurement technique for muscle mass using discrete multi-wavelength near-infrared spectroscopy (DMW-NIRS) compared with multifrequency bioelectrical impedance analysis (BIA) in older adults. (2) Methods: In a cross-sectional study involving 91 participants aged 65 years, the agreement of total lean mass for each measurement was
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Lead Break during Extraction: Predisposing Factors and Impact on Procedure Complexity and Outcome: Analysis of 3825 Procedures J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Andrzej Kutarski, Wojciech Jacheć, Marek Czajkowski, Paweł Stefańczyk, Jarosław Kosior, Łukasz Tułecki, Dorota Nowosielecka
Background: Currently, there are no reports describing lead break (LB) during transvenous lead extraction (TLE). Methods: This study conducted a retrospective analysis of 3825 consecutive TLEs using mechanical sheaths. Results: Fracture of the lead, defined as LB, with a long lead fragment (LF) occurred in 2.48%, LB with a short LF in 1.20%, LB with the tip of the lead in 1.78%, and LB with loss of
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Negative Pressure Wound Therapy—A Vacuum-Mediated Positive Pressure Wound Therapy and a Closer Look at the Role of the Laser Doppler J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Christian D. Taeger, Clemens Muehle, Philipp Kruppa, Lukas Prantl, Niklas Biermann
Background: Negative pressure wound therapy (NPWT) is an intensely investigated topic, but its mechanism of action accounts for one of the least understood ones in the area of wound healing. Apart from a misleading nomenclature, by far the most used diagnostic tool to investigate NPWT, the laser Doppler, also has its weaknesses regarding the detection of changes in blood flow and velocity. The aim
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Impact of Bronchoscopic Lung Volume Reduction with Valves on the Pulmonary Gas Exchange J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Jane Winantea, Katharina Stiehl, Ruediger Karpf-Wissel, Faustina Funke, Hubertus Hautzel, Birte Schwarz, Heinz Steveling, Christian Taube, Filiz Oezkan, Kaid Darwiche
Introduction: Bronchoscopic lung volume reduction (BLVR) with endobronchial valves has been shown to be a safe and effective treatment for patients with severe lung emphysema. Previous studies have reported a benefit in pulmonary function, exercise capacity, and quality of life after BLVR-treatment. The effect of BLVR with valves on the pulmonary gas exchange and its association with clinical outcomes
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Are There Sex-Related Differences in the Effectiveness of Janus Kinase Inhibitors in Rheumatoid Arthritis Patients? J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Cristina Martinez-Molina, Anna Feliu, Hye S. Park, Ana Juanes, Cesar Diaz-Torne, Silvia Vidal, Hèctor Corominas
Background: There is evidence suggesting the existence of sex differences in the effectiveness of specific drug classes for rheumatoid arthritis (RA). Our study stands as the first to elucidate sex-related differences in the effectiveness of Janus kinase (JAK) inhibitors. Methods: The study involved 150 RA patients treated with tofacitinib, baricitinib, upadacitinib, or filgotinib between September
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Comment on Barbieri et al. Umbilical Vein Blood Flow in Uncomplicated Pregnancies: Systemic Review of Available Reference Charts and Comparison with a New Cohort. J. Clin. Med. 2023, 12, 3132 J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Jonathan M. Rubin, Oliver D. Kripfgans
We would like to comment on the systemic review article published in the Journal of Clinical Medicine by Barbieri et al [...]
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Congenital Haemostasis Disorders and Urology Surgery: Is It Safe? J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Antoine Bres, Thibaut Waeckel, Yohann Repesse, Xavier Tillou
Background: There are no specific recommendations for the management of patients with bleeding disorders (BD), such as haemophilia A (HA), haemophilia B (HB), or von Willebrand disease (WD), in urology surgery. Methods: We conducted a retrospective study of 32 patients with HA, HB, or WD of any severity. Fifty-seven procedures were performed between January 2017 and September 2023. Surgical interventions
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Data-Driven Surveillance Protocol for Patients at Risk for Peritoneal Recurrence of Primary Colon Cancer: Surveillance for Peritoneal Carcinomatosis J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Meloria A. Hoskins, Adam Finkelstein, Aisha Rashid, Olivia Ziegler, Marc M. Mankarious, Jorge V. Benavides, Colette R. Pameijer
Peritoneal carcinomatosis (PC) is rarely discovered early due to low sensitivity of screening imaging and tumor markers, however, earlier identification may improve outcomes. This study assesses risk factors and time to recurrence of PC and implementation of a surveillance system. Patients with stage II–III colon adenocarcinoma undergoing curative colectomy between 2005–2022 were retrospectively reviewed
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Comparative Efficacy of Transsphenoidal and Transcranial Approaches for Treating Tuberculum Sellae Meningiomas: A Systematic Review and Meta-Analysis J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Edoardo Agosti, A. Yohan Alexander, Sara Antonietti, Marco Zeppieri, Amedeo Piazza, Pier Paolo Panciani, Marco Maria Fontanella, Carlos Pinheiro-Neto, Tamara Ius, Maria Peris-Celda
Background/Objectives: Tuberculum sellae meningiomas (TSMs) constitute 5–10% of intracranial meningiomas, often causing visual impairment. Traditional microsurgical transcranial approaches (MTAs) have been effective, but the emergence of innovative surgical trajectories, such as endoscopic endonasal approaches (EEAs), has sparked debate. While EEAs offer advantages like reduced brain retraction, they
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Comparison between Conventional and Digital Impressions for Determining Axes and Distances of Three Implants in Straight and Curved Lines: An In Vitro Study J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Gil Ben-Izhack, Ophir Rosner, Eran Zenziper, Joseph Nissan, Reema Hosary, Diva Lugassy, Asaf Shely
Background: In this study, we aimed to compare the effects of conventional and digital impressions on several parameters (inter-implant distance, intra-implant distance, inter-implant axis, and intra-implant axis) of three implants in curved lines and straight lines by using a laboratory scanner (LBS) versus an intra-oral scanner (IOS). Methods: Two 3D models were fabricated using a printer, each model
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Spectral Photon-Counting Computed Tomography: Technical Principles and Applications in the Assessment of Cardiovascular Diseases J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Antonella Meloni, Erica Maffei, Alberto Clemente, Carmelo De Gori, Mariaelena Occhipinti, Vicenzo Positano, Sergio Berti, Ludovico La Grutta, Luca Saba, Riccardo Cau, Eduardo Bossone, Cesare Mantini, Carlo Cavaliere, Bruna Punzo, Simona Celi, Filippo Cademartiri
Spectral Photon-Counting Computed Tomography (SPCCT) represents a groundbreaking advancement in X-ray imaging technology. The core innovation of SPCCT lies in its photon-counting detectors, which can count the exact number of incoming x-ray photons and individually measure their energy. The first part of this review summarizes the key elements of SPCCT technology, such as energy binning, energy weighting
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The Role of Helicobacter pylori and Metabolic Syndrome-Related Mast Cell Activation Pathologies and Their Potential Impact on Pregnancy and Neonatal Outcomes J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Maria Tzitiridou-Chatzopoulou, Evangelos Kazakos, Eirini Orovou, Paraskevi Eva Andronikidi, Foteini Kyrailidi, Maria C. Mouratidou, Georgios Iatrakis, Jannis Kountouras
Helicobacter pylori infection, a significant global burden beyond the gastrointestinal tract, has long been implicated in various systemic pathologies. Rising evidence suggests that the bacterium’s intricate relationship with the immune system and its potential to induce chronic inflammation impact diverse pathophysiological processes in pregnant women that may in turn affect the incidence of several
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APOE Genotype, ApoE Plasma Levels, Lipid Metabolism, and Cognition in Monozygotic Twins with, at Risk of, and without Affective Disorders J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Jon Dyg Sperling, Ruth Frikke-Schmidt, Thomas Scheike, Lars Vedel Kessing, Kamilla Miskowiak, Maj Vinberg
Background: Lipids influence brain function and mental health. Understanding the role of apolipoproteins in affective disorders could provide valuable insights and potentially pave the way for novel therapeutic approaches. Methods: We examined the apolipoprotein E genotype and ApoE-levels, lipid profiles, and the correlation with cognition in 204 monozygotic (MZ) twins with unipolar or bipolar disorder
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Machine Learning Prediction of Tongue Pressure in Elderly Patients with Head and Neck Tumor: A Cross-Sectional Study J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Xuewei Han, Ziyi Bai, Kaoru Mogushi, Takeshi Hase, Katsuyuki Takeuchi, Yoritsugu Iida, Yuka I. Sumita, Noriyuki Wakabayashi
Background: This investigation sought to cross validate the predictors of tongue pressure recovery in elderly patients’ post-treatment for head and neck tumors, leveraging advanced machine learning techniques. Methods: By employing logistic regression, support vector regression, random forest, and extreme gradient boosting, the study analyzed an array of variables including patient demographics, surgery
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A Glimpse into the Role and Effectiveness of Splenectomy for Isolated Metachronous Spleen Metastasis of Colorectal Cancer Origin: Long-Term Survivals Can Be Achieved J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Beatrice Mihaela Tivadar, Traian Dumitrascu, Catalin Vasilescu
Background: Many papers exploring the role of resectioning metastases in colorectal cancer (CRC) have focused mainly on liver and lung sites, showing improved survival compared with non-resectional therapies. However, data about exceptional metastatic sites such as splenic metastases (SMs) are scarce. This paper aims to assess the role and effectiveness of splenectomy in the case of isolated metachronous
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Comparison of Hemodynamic Parameters Based on the Administration of Remimazolam or Sevoflurane in Patients under General Anesthesia in the Beach Chair Position: A Single-Blinded Randomized Controlled Trial J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Sangho Lee, Jimung Seo, Doh Yoon Kim, YoungYun Lee, Hee Yong Kang, Jeong-Hyun Choi, Youngsoon Kim, Mi Kyeong Kim, Ann Hee You
Background: We aimed to evaluate whether the administration of remimazolam as a maintenance agent for general anesthesia affects the occurrence of hypotension compared with sevoflurane when switching to the beach chair position (BCP). Methods: We conducted a prospective randomized controlled trial from June 2023 to October 2023 in adult patients undergoing orthopedic surgery under general anesthesia
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Back Pain in Adolescents and Young Adults with Idiopathic Scoliosis—Identifying Factors Associated with Significant Pain—A Multivariate Logistic Regression Analysis J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Juan Bagó, Antonia Matamalas, Javier Pizones, Jesús Betegón, Judith Sánchez-Raya, Ferran Pellisé
(1) Background: Previous data show that patients with idiopathic scoliosis (IS) can be classified into two groups according to pain intensity. This paper aims to determine which factors can independently predict the likelihood of belonging to a high-level pain group. (2) Methods: The study used a prospective, multicenter, cross-sectional design. Two-hundred and seventy-two patients with IS (mean age
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Acute Kidney Injury in Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention: The Role of Vascular Access Site J. Clin. Med. (IF 3.9) Pub Date : 2024-04-18 Stefano Rigattieri, Ernesto Cristiano, Federica Tempestini, Luca Pittorino, Vincenzo Cesario, Matteo Casenghi, Francesca Giovannelli, Antonella Tommasino, Emanuele Barbato, Andrea Berni
Background: in patients undergoing percutaneous coronary interventions (PCI), radial access should be favoured over femoral access as it reduces the risk of vascular complications and bleeding. Furthermore, a preventive role of radial access in the occurrence of acute kidney injury (AKI), mainly mediated by the reduction of bleeding and cholesterol crystal embolization into renal circulation, has been