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The Predictive Factors Associated with In-Hospital Mortality of Melioidosis: A Cohort Study Medicina (IF 2.948) Pub Date : 2024-04-19 Sunee Chayangsu, Chusana Suankratay, Apichat Tantraworasin, Jiraporn Khorana
Background and Objectives: Melioidosis is an infectious disease caused by Burkholderia pseudomallei, and it has a wide range of clinical symptoms. It is endemic in tropical areas, including Southeast Asia. Despite the availability of effective treatment, the mortality rate is still high, especially in patients presenting with septic shock. The aim of this study was to determine and explore clinical
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Noninvasive Ambulatory Electrocardiographic Markers from Patients with COVID-19 Pneumonia: A Report of Three Cases Medicina (IF 2.948) Pub Date : 2024-04-19 Motohiro Kimata, Kenichi Hashimoto, Naomi Harada, Yusuke Kawamura, Yoshifumi Kimizuka, Yuji Fujikura, Mayuko Kaneko, Nobuaki Kiriu, Yasumasa Sekine, Natsumi Iwabuchi, Tetsuro Kiyozumi, Akihiko Kawana, Susumu Matsukuma, Yuji Tanaka
Coronavirus disease 2019 (COVID-19) has affected medical practice. More than 7,000,000 patients died worldwide after being infected with COVID-19; however, no specific laboratory markers have yet been established to predict death related to this disease. In contrast, electrocardiographic changes due to COVID-19 include QT prolongation and ST-T changes; however, there have not been studies on the ambulatory
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Retrospective Evaluation of the Efficacy of Total Neoadjuvant Therapy and Chemoradiotherapy Neoadjuvant Treatment in Relation to Surgery in Patients with Rectal Cancer Medicina (IF 2.948) Pub Date : 2024-04-19 Lucian Dragoș Bratu, Michael Schenker, Puiu Olivian Stovicek, Ramona Adriana Schenker, Alina Maria Mehedințeanu, Tradian Ciprian Berisha, Andreas Donoiu, Stelian Ștefăniță Mogoantă
Background and Objective: In the therapeutic strategy of rectal cancer, radiotherapy has consolidated its important position and frequent use in current practice due to its indications as neoadjuvant, adjuvant, definitive, or palliative treatment. In recent years, total neoadjuvant therapy (TNT) has been established as the preferred regimen compared to concurrent neoadjuvant chemoradiotherapy (CRT)
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Assessment and Application of the Hear Score in Remote Emergency Medicine Outposts in Bosnia and Herzegovina Medicina (IF 2.948) Pub Date : 2024-04-19 Armin Šljivo, Nemanja Lukić, Aladin Altic, Slobodan Tomić, Arian Abdulkhaliq, Leopold Reiter, Diana Maria Bota, Eljakim Mahendran, Wisam Natour, Fatima Gavrankapetanović, Emira Kapisazović, Haris Duljević, Lana Lekić, Dragana Radoičić, Sanja D Tomić
Background and Objectives. In emergency departments, chest pain is a common concern, highlighting the critical importance of distinguishing between acute coronary syndrome and other potential causes. Our research aimed to introduce and implement the HEAR score, specifically, in remote emergency outposts in Bosnia and Herzegovina. Materials and Methods. This follow-up study conducted a retrospective
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Long-Term Alterations in Motor Skills, Neurogenesis and Astrocyte Numbers following Transient Cerebral Ischemia in Mice Medicina (IF 2.948) Pub Date : 2024-04-19 Vladimirs Pilipenko, Jolanta Upite, Beatrise Luize Revina, Baiba Jansone
Background and Objectives. Neurogenesis is an integral process in post-stroke recovery, involving the recruitment of proliferating neuroblasts from neurogenic niches of the mammal brain. However, the role of neurogenesis in the long-term restoration following ischemic stroke is fragmented. Post-stroke motor dysfunction includes challenges in the proper, coordinated use of hands and is present in roughly
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Comparing the Risk of Infusion-Related Reactions and Tolerability in Patients Given Cetirizine or Diphenhydramine Prior to Ocrelizumab Infusion (PRECEPT) Medicina (IF 2.948) Pub Date : 2024-04-19 Kyle Smoot, Horia Marginean, Tiffany Gervasi-Follmar, Chiayi Chen
Background: Ocrelizumab is an effective medication for multiple sclerosis. However, infusion-related reactions (IRRs) are a concern for patients and may lead to discontinuation of ocrelizumab. To minimize IRRs, pre-medications are administered. However, from our experience, these medications, especially diphenhydramine, can cause marked drowsiness. The primary objective of this study was to evaluate
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Human Papillomavirus Is Rare and Does Not Correlate with p16INK4A Expression in Non-Small-Cell Lung Cancer in a Jordanian Subpopulation Medicina (IF 2.948) Pub Date : 2024-04-19 Ola Abu Al Karsaneh, Arwa Al Anber, Sahar AlMustafa, Hussien AlMa’aitah, Batool AlQadri, Abir Igbaria, Rama Tayem, Mustafa Khasawneh, Shaima Batayha, Tareq Saleh, Mohammad ALQudah, Maher Sughayer
Background and Objectives: Human papillomavirus (HPV) was previously investigated in lung cancer with wide inter-geographic discrepancies. p16INK4a has been used as a surrogate for detecting high-risk HPV (HR-HPV) in some cancer types. This study assessed the evidence of HPV in non-small-cell lung cancer (NSCLC) among Jordanian patients, investigated the expression of p16INK4a, and evaluated its prognostic
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Investigation of the Association between Bilateral Selective Anterograde Cerebral Perfusion and Postoperative Ischemic Stroke in Obese Patients with Emergency Surgery for Acute Type A Aortic Dissection Medicina (IF 2.948) Pub Date : 2024-04-19 Mircea Robu, Bogdan Radulescu, Irina Maria Margarint, Cornel Robu, Ovidiu Stiru, Andrei Iosifescu, Silvia Preda, Mihai Cacoveanu, Cristian Voica, Vlad Anton Iliescu, Horatiu Moldovan
Background and objectives: The relationship between cerebral perfusion and new postoperative ischemic stroke in obese patients is not well defined. The aim of this study was to investigate the association between selective bilateral anterograde cerebral perfusion and new postoperative ischemic stroke in obese patients with emergency surgery for acute type A aortic dissection. Materials and methods:
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Peak Resembling N-acetylaspartate (NAA) on Magnetic Resonance Spectroscopy of Brain Metastases Medicina (IF 2.948) Pub Date : 2024-04-19 Jelena Ostojic, Dusko Kozic, Milana Panjkovic, Biljana Georgievski-Brkic, Dusan Dragicevic, Aleksandra Lovrenski, Jasmina Boban
Background and Objectives: Differentiating between a high-grade glioma (HGG) and solitary cerebral metastasis presents a challenge when using standard magnetic resonance imaging (MRI) alone. Magnetic resonance spectroscopy (MRS), an advanced MRI technique, may assist in resolving this diagnostic dilemma. N-acetylaspartate (NAA), an amino acid found uniquely in the central nervous system and in high
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Evaluation of the Psychometric Properties of the Musculoskeletal Health Questionnaire (MSK-HQ) in a Population of Professional Basketball Players: A Cross-Sectional Study Medicina (IF 2.948) Pub Date : 2024-04-19 Giovanni Galeoto, Kennet Matteo Viglianisi, Anna Berardi, Giovanni Sellitto, Ilaria Ruotolo, Rachele Simeon, Alessandra Carlizza
Background and Objective: Musculoskeletal disorders affect a large portion of the population worldwide. The musculoskeletal health questionnaire is a helpful tool for assessing the health state of patients with these disorders. The primary goal of this study is to evaluate the psychometric properties of the MSK_HQ-IT in a population of professional basketball players. The secondary aim is to assess
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Prevalence and Risk Factors of Osteoarthritis in Korea: A Cross-Sectional Study Medicina (IF 2.948) Pub Date : 2024-04-19 Do-Youn Lee
Background and Objectives: The goal of this study is to determine the prevalence of knee osteoarthritis (OA) and risk factors for the disease in Korean adults over the age of 50, as well as to provide basic data for OA prevention through management. Materials and Methods: Based on 2010–2013 data from the Korean National Health and Nutrition Survey, 7962 adults over the age of 50 who participated in
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The Effect of Recruitment Maneuver on Static Lung Compliance in Patients Undergoing General Anesthesia for Laparoscopic Cholecystectomy: A Single-Centre Prospective Clinical Intervention Study Medicina (IF 2.948) Pub Date : 2024-04-19 Nada Anđelić, Arsen Uvelin, Edita Stokić, Radmila Popović, Ranko Zdravković, Andrej Preveden, Nenad Zornić
Background and Objectives: The aim of this study was to examine whether the use of an alveolar recruitment maneuver (RM) leads to a significant increase in static lung compliance (Cstat) and an improvement in gas exchange in patients undergoing laparoscopic cholecystectomy. Material and Methods: A clinical prospective intervention study was conducted. Patients were divided into two groups according
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Histologically Validated Myocardial Fibrosis in Relation to Left Ventricular Geometry and Its Function in Aortic Stenosis Medicina (IF 2.948) Pub Date : 2024-04-19 Serik Aitaliyev, Egle Rumbinaitė, Martynas Jurenas, Indrė Čeponienė, Vytenis Keturakis, Rokas Nekrošius, Yerlan Orazymbetov, Rimantas Benetis, Dalia Pangonytė
Background and Objectives: The combination of aortic valve stenosis (AS) and ischemic heart disease (IHD) is quite common and is associated with myocardial fibrosis (MF). The purpose of this study was to evaluate the association between the histologically verified left ventricular (LV) MF and its geometry and function in isolated AS and AS within IHD groups. Materials and Methods: In a single-center
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Postoperative Morbidity after Dental Treatment under General Anesthesia in Children with and without Disabilities Medicina (IF 2.948) Pub Date : 2024-04-19 Marija Šimunović-Erpušina, Danko Bakarčić, Odri Cicvarić, Luka Šimunović, Vlatka Sotošek, Dorotea Petrović, Nataša Ivančić Jokić
Background and Objectives: General anesthesia induces reversible unconsciousness, eliminating sensation and enabling painless medical procedures. Vital for dental care, it addresses patients with medical conditions, those needing extensive procedures, and those unable to cooperate due to fear. Dental care for patients with disabilities is a significant unmet need, with studies showing increased oral
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Consumption of Dietary Supplements among Working-Age Residents of Lithuania in the Period from 2021 to 2023 Medicina (IF 2.948) Pub Date : 2024-04-19 Rokas Arlauskas, Donatas Austys, Valerij Dobrovolskij, Rimantas Stukas
Background and Objectives: The aim of this study was to assess the consumption of dietary supplements (DS) among working-age residents of Lithuania from 2021 to 2023 with respect to social and demographic factors and an assessment of personal health. Materials and Methods: Using stratified sampling techniques, this study included three samples of working-age residents (1600 each year, 4800 total).
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Olmutinib Reverses Thioacetamide-Induced Cell Cycle Gene Alterations in Mice Liver and Kidney Tissues, While Wheat Germ Treatment Exhibits Limited Efficacy at Gene Level Medicina (IF 2.948) Pub Date : 2024-04-16 Seema Zargar, Tanveer A. Wani, Salman Alamery, Fatimah Yaseen
Background and Objectives: TAA is potent hepatic/renal toxicant. Conversely, WGO is a potent dietary supplement with impressive antioxidant properties. Olmutinib is an apoptotic chemotherapy drug that does not harm the liver or kidney. This study investigated the impact of olmutinib and wheat germ oil (WGO) on Thioacetamide (TAA)-induced gene alterations in mice liver and kidney tissues. Materials
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Socioeconomic and Other Risk Factors for Retear after Arthroscopic Surgery for Nontraumatic Rotator Cuff Tear Medicina (IF 2.948) Pub Date : 2024-04-17 Jung Sub Lee, Kuen Tak Suh, Won Chul Shin, Jung Yun Bae, Tae Sik Goh, Sung Won Jung, Min-Hyeok Choi, Suk-Woong Kang
Background and Objectives: Few studies have investigated the socioeconomic factors associated with retear after rotator cuff repair. This study aimed to identify the risk factors, including socioeconomic factors, for rotator cuff retear in patients who underwent arthroscopic rotator cuff repair. Materials and Methods: This retrospective study included 723 patients diagnosed with full-thickness rotator
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Acute Infectious Purpura Fulminans Complicated by Bacterial Translocation after Rectal Cancer Surgery: A Case Report Medicina (IF 2.948) Pub Date : 2024-04-17 Ryo Nakanishi, Heita Ozawa, Naoyuki Toyota, Minori Mise, Ritsuto Akutsu, Shin Fujita
The patient was a man in his 80s who had undergone laparoscopic anterior resection for rectal cancer. Bowel obstruction occurred on the third postoperative day but improved with a decompression tube by the fifth postoperative day. A high fever (in the 38 °C range) was also observed. Blood culture tests detected two sets of the gram-negative bacilli Klebsiella aerogenes within 24 h of collection. On
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The Effect of Intraoperative Patient Positioning on the Success of Intertrochanteric Fracture Surgery in Older Patients Medicina (IF 2.948) Pub Date : 2024-04-18 Onur Kaya, Buğra Kundakçı, Cem Önder, Vahap Kurt, Emre Atmaca, Fatih Tunç
Background and Objectives: The incidence of hip fractures in people of advanced ages is increasing due to our aging society. Patient positioning for the intertrochanteric fractures of the femur can be performed in various ways. The aim of this study is to clinically and radiologically compare the use of the supine hemilithotomy position, the lateral decubitus position, and the traction table when performing
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Use of Reverse Shock Index Multiplied by Simplified Motor Score in a Five-Level Triage System: Identifying Trauma in Adult Patients at a High Risk of Mortality Medicina (IF 2.948) Pub Date : 2024-04-18 Po-Chen Lin, Meng-Yu Wu, Da-Sen Chien, Jui-Yuan Chung, Chi-Yuan Liu, I-Shiang Tzeng, Yueh-Tseng Hou, Yu-Long Chen, Giou-Teng Yiang
Background and Objectives: The Taiwan Triage and Acuity Scale (TTAS) is reliable for triaging patients in emergency departments in Taiwan; however, most triage decisions are still based on chief complaints. The reverse-shock index (SI) multiplied by the simplified motor score (rSI-sMS) is a more comprehensive approach to triage that combines the SI and a modified consciousness assessment. We investigated
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Cracking the Code: Investigating the Correlation between Aerobic Vaginitis and Preterm Labor Medicina (IF 2.948) Pub Date : 2024-04-18 Panagiota Zarmakoupi, Alexandros Psarris, Christina Karasmani, Panagiotis Antsaklis, Marianna Theodora, Michael Syndos, Andreas Pampanos, Kalliopi I. Pappa, Ekaterini Domali, Nikolaos Thomakos, Karolina Akinosoglou, Aristotelis Tsiakalos, George Daskalakis
Aerobic vaginitis (AV) is a distinct clinical entity characterized by inflammation and abnormal vaginal microflora. Often mistaken for bacterial vaginosis, AV remains relatively unknown and underdiagnosed. AV’s understanding is evolving, with some experts suggesting it may primarily be an immunological disorder, the prevalence of which has a range of 7–13% in non-pregnant women and 4.1–8.3% during
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The Effect of Pringle Maneuver Applied during Living Donor Hepatectomy on the Ischemia-Reperfusion Injury Observed in the Donors and Recipients Medicina (IF 2.948) Pub Date : 2024-04-18 Yasin Dalda, Sami Akbulut, Tevfik Tolga Sahin, Adem Tuncer, Zeki Ogut, Basri Satilmis, Ozlem Dalda, Mehmet Gul, Sezai Yilmaz
Background and Objectives: The aim of this study is to evaluate the clinical and laboratory changes of ischemia and reperfusion injury in the remnant livers of donors with and without Pringle maneuver. Furthermore, we evaluated the recipients who have been transplanted with liver grafts from these donors. Methods and Materials: A total of 108 patients (54 living liver donors and 54 liver recipients)
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Addressing Thalassaemia Management from Patients’ Perspectives: An International Collaborative Assessment Medicina (IF 2.948) Pub Date : 2024-04-18 Eleftheria C. Economidou, Michael Angastiniotis, Demetris Avraam, Elpidoforos S. Soteriades, Androulla Eleftheriou
Background and Objectives: The effective management of chronic diseases, particularly hereditary and rare diseases and thalassaemia, is an important indicator of the quality of healthcare systems. We aimed to assess healthcare services in different countries for thalassaemia patients by using publicly available health indicators and by surveying thalassaemia patients and their caregivers. Materials
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Uterine Cesarean Scar Tissue—An Immunohistochemical Study Medicina (IF 2.948) Pub Date : 2024-04-18 Maciej Ziętek, Małgorzata Świątkowska-Feund, Sylwester Ciećwież, Tomasz Machałowski, Małgorzata Szczuko
Background and Objectives: Wound healing encompasses a multitude of factors and entails the establishment of interactions among components of the basement membrane. The quantification of particle concentrations can serve as valuable biomarkers for assessing biomechanical muscle properties. The objective of this study was to examine the immunoexpression and immunoconcentration of myometrial collagen
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Effects of the Neuropeptides Pituitary Adenylate Cyclase Activating Polypeptide and Vasoactive Intestinal Peptide in Male Fertility Medicina (IF 2.948) Pub Date : 2024-04-18 Roba Bdeir, Maha S. Al-Keilani, Khaldoun Khamaiseh
Background and Objectives: The neuroendocrine system plays a crucial role in regulating various bodily functions, including reproduction, with evidence suggesting its significant involvement in male fertility and sperm development. Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) are expressed in both male and female reproductive tissues, influencing
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Health Effects of Ionizing Radiation on the Human Body Medicina (IF 2.948) Pub Date : 2024-04-18 Jasminka Talapko, Domagoj Talapko, Darko Katalinić, Ivan Kotris, Ivan Erić, Dino Belić, Mila Vasilj Mihaljević, Ana Vasilj, Suzana Erić, Josipa Flam, Sanja Bekić, Suzana Matić, Ivana Škrlec
Radioactivity is a process in which the nuclei of unstable atoms spontaneously decay, producing other nuclei and releasing energy in the form of ionizing radiation in the form of alpha (α) and beta (β) particles as well as the emission of gamma (γ) electromagnetic waves. People may be exposed to radiation in various forms, as casualties of nuclear accidents, workers in power plants, or while working
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Association between Genetic Polymorphism of SCN1A, GABRA1 and ABCB1 and Drug Responsiveness in Vietnamese Epileptic Children Medicina (IF 2.948) Pub Date : 2024-04-16 Hai Xuan Tang, Muoi Dang Ho, Nhung Phuong Vu, Hung Vu Cao, Vinh Anh Ngo, Van Thi Nguyen, Thuan Duc Nguyen, Ton Dang Nguyen
Background and Objectives: Drug resistant epilepsy (DRE) is a major hurdle in epilepsy, which hinders clinical care, patients’ management and treatment outcomes. DRE may partially result from genetic variants that alter proteins responsible for drug targets and drug transporters in the brain. We aimed to examine the relationship between SCN1A, GABRA1 and ABCB1 polymorphism and drug response in epilepsy
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Management of Malignant Gastric Outlet Obstruction: A Comprehensive Review on the Old, the Classic and the Innovative Approaches Medicina (IF 2.948) Pub Date : 2024-04-16 Alessandro Fugazza, Marta Andreozzi, Hamid Asadzadeh Aghdaei, Agustin Insausti, Marco Spadaccini, Matteo Colombo, Silvia Carrara, Maria Terrin, Alessandro De Marco, Gianluca Franchellucci, Kareem Khalaf, Pardis Ketabi Moghadam, Chiara Ferrari, Andrea Anderloni, Giovanni Capretti, Gennaro Nappo, Alessandro Zerbi, Alessandro Repici
Gastrojejunostomy is the principal method of palliation for unresectable malignant gastric outlet obstructions (GOO). Gastrojejunostomy was traditionally performed as a surgical procedure with an open approach butrecently, notable progress in the development of minimally invasive procedures such as laparoscopic gastrojejunostomies have emerged. Additionally, advancements in endoscopic techniques, including
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O2 Saturation Predicted the ICU Stay of COVID-19 Patients in a Hospital at Altitude: A Low-Cost Tool for Post-Pandemic Medicina (IF 2.948) Pub Date : 2024-04-17 Jaime Vásquez-Gómez, Lucero Gutierrez-Gutierrez, Pablo Miranda-Cuevas, Luis Ríos-Florez, Luz Casas-Condori, Marcia Gumiel, Marcelo Castillo-Retamal
Background and Objectives: Patients at high altitudes with COVID-19 may experience a decrease in their partial oxygen saturation (PO2S) levels. The objective was to assess the association between PO2S and intensive care unit (ICU) stay in patients at high altitudes with COVID-19. Materials and Methods: Clinical records of 69 COVID-19 patients (36% women) admitted to the ICU were analyzed. Median values
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Relationship between Depressive Symptoms, Caregiver Strain, and Social Support with Dementia Grief in Family Caregivers Medicina (IF 2.948) Pub Date : 2024-04-17 Miriam Sánchez-Alcón, Almudena Garrido-Fernández, José María Cano-Rojas, José Luis Sánchez-Ramos, Juan Diego Ramos-Pichardo
Background and Objectives: Dementia grief in family caregivers of people with dementia refers to grieving prior to the death of the care recipient. It is related to psychosocial risk factors that may have a negative impact on the health of these family caregivers. This study aimed to describe the relationship between depressive symptoms, caregiver strain, and social support with dementia grief in family
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Adherence to the Mediterranean Diet in Saudi Arabia and Its Association with Socioeconomic Status and Depression Medicina (IF 2.948) Pub Date : 2024-04-17 Majed Alnabulsi, Ahmad Abdullah Imam, Atheer Ahmed Alawlaqi, Fatimah Hussain Alhawaj, Ghazal Fareed Jamjoom, Lina Dakhil Alsaeidi, Fatma El-Sayed Hassan, Shakeel Ahmed Ansari
Background and Objectives: Several RCTs have reported significant reductions in depression symptoms with the Mediterranean diet (MedDiet), but observational studies have reported inconsistent findings. Moreover, studies have rarely investigated the mediating role of socioeconomic status (SES), including objective material status, in adherence to the MedDiet and its impact on depressive symptoms in
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Integrating Clinical Neuropsychology and Psychotic Spectrum Disorders: A Systematic Analysis of Cognitive Dynamics, Interventions, and Underlying Mechanisms Medicina (IF 2.948) Pub Date : 2024-04-17 Evgenia Gkintoni, Maria Skokou, Philippos Gourzis
Background and Objectives: The study aims to provide a comprehensive neuropsychological analysis of psychotic spectrum disorders, including schizophrenia, bipolar disorder, and depression. It focuses on the critical aspects of cognitive impairments, diagnostic tools, intervention efficacy, and the roles of genetic and environmental factors in these disorders. The paper emphasizes the diagnostic significance
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Treatment Nonadherence among Multimorbid Chronic Disease Patients: Evidence from 3515 Subjects in Indonesia Medicina (IF 2.948) Pub Date : 2024-04-15 Ivan Surya Pradipta, Kevin Aprilio, Yozi Fiedya Ningsih, Mochammad Andhika Aji Pratama, Sofa Dewi Alfian, Rizky Abdulah
Background and Objectives: Multimorbid patients require intensive treatment for their diseases. However, little research has been given to their treatment adherence as part of its management. This study aims to determine the prevalence and characteristics of chronic disease multimorbidity in Indonesia, alongside its treatment nonadherence. Materials and Methods: We conducted a cross-sectional study
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Beyond Weight Loss: A Comprehensive Review of Pregnancy Management following Bariatric Procedures Medicina (IF 2.948) Pub Date : 2024-04-15 Iulia Huluță, Livia-Mihaela Apostol, Radu Botezatu, Anca Maria Panaitescu, Corina Gică, Romina-Marina Sima, Nicolae Gică, Florina Mihaela Nedelea
The increasing prevalence of bariatric surgery among women of childbearing age raises critical questions about the correct management of pregnancy following these procedures. This literature review delves into the multifaceted considerations surrounding pregnancy after bariatric surgery, with a particular focus on the importance of preconception counselling, appropriate nutrition assessment, and the
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Time Course of Asymptomatic Stenosis in Multiple Lumbar Spinal Stenosis—Five-Year Results of Selective Decompression of Symptomatic Levels Medicina (IF 2.948) Pub Date : 2024-04-15 Kazuyuki Watanabe, Koji Otani, Takuya Nikaido, Kinshi Kato, Hiroshi Kobayashi, Shoji Yabuki, Shin-ichi Konno, Yoshihiro Matsumoto
Background: In the diagnosis of lumbar spinal stenosis (LSS), finding stenosis with magnetic resonance imaging (MRI) does not always correlate with symptoms such as sciatica or intermittent claudication. We perform decompression surgery only for cases where the levels diagnosed from neurological findings are symptomatic, even if multiple stenoses are observed on MRI. The objective of this study was
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Assessing the Feasibility and Efficacy of Pre-Sleep Dim Light Therapy for Adults with Insomnia: A Pilot Study Medicina (IF 2.948) Pub Date : 2024-04-14 Jihyun Yoon, Seok-Jae Heo, Hyangkyu Lee, Eun-Gyeong Sul, Taehwa Han, Yu-Jin Kwon
Background: Insomnia is increasingly recognized for its marked impact on public health and is often associated with various adverse health outcomes, including cardiovascular diseases and mental health disorders. The aim of this study was to investigate the efficacy of pre-sleep dim light therapy (LT) as a non-pharmacological intervention for insomnia in adults, assessing its influence on sleep parameters
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Endoscopic Gallbladder Drainage: A Comprehensive Review on Indications, Techniques, and Future Perspectives Medicina (IF 2.948) Pub Date : 2024-04-14 Edoardo Troncone, Rosa Amendola, Alessandro Moscardelli, Elena De Cristofaro, Pasquale De Vico, Omero Alessandro Paoluzi, Giovanni Monteleone, Manuel Perez-Miranda, Giovanna Del Vecchio Blanco
In recent years, therapeutic endoscopy has become a fundamental tool in the management of gallbladder diseases in light of its minimal invasiveness, high clinical efficacy, and good safety profile. Both endoscopic transpapillary gallbladder drainage (TGBD) and endoscopic ultrasound (EUS)-guided gallbladder drainage (EUS-GBD) provide effective internal drainage in patients with acute cholecystitis unfit
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Breast Cancer in Patients with Previous Endometriosis Showed Low Aggressive Subtype Medicina (IF 2.948) Pub Date : 2024-04-12 Gianluca Vanni, Aikaterini Selntigia, Valentina Enrica Marsella, Consuelo Russo, Marco Pellicciaro, Marco Materazzo, Giuseppe Rizzo, Oreste Claudio Buonomo, Caterina Exacoustos
Background and Objectives: The association between endometriosis and breast cancer still remains controversial. The aim of this study was to investigate the different subtypes of breast cancer, immunohistochemical markers, hormone receptors, and ki67 proliferation indexes in patients with and without endometriosis and/or adenomyosis. Materials and Methods: All patients with endometriosis and breast
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The Impact of Platelet-Rich Plasma Application during Cesarean Section on Wound Healing and Postoperative Pain: A Single-Blind Placebo-Controlled Intervention Study Medicina (IF 2.948) Pub Date : 2024-04-13 Michał Barwijuk, Katarzyna Pankiewicz, Aleksander Gałaś, Filip Nowakowski, Patrycja Gumuła, Artur J. Jakimiuk, Tadeusz Issat
Background/Objectives: The aim of this study was to evaluate if platelet-rich plasma (PRP) application into the wound during cesarean delivery improves wound healing and reduces pain in the postoperative period. Materials and Methods: A total of 46 patients undergoing cesarean section (CS) were included in this single-blind placebo-controlled intervention study: 23 women in the PRP group and 23 in
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Efficacy of Lidocaine Spray for Pain Reduction during Colposcopy-Directed Cervical Biopsies: A Randomized Controlled Trial Medicina (IF 2.948) Pub Date : 2024-04-13 Ornwitsanate Mongkolmafai, Dhammapoj Jeerakornpassawat, Charuwan Tantipalakorn, Kittipat Charoenkwan, Prapaporn Suprasert, Jatupol Srisomboon, Theera Tongsong
Objectives: The objective of this study was to evaluate the efficacy of lidocaine spray in reducing the pain during colposcopy-directed cervical biopsy (CDB). Methods: From December 2017 to February 2019, 312 women undergoing CDBs were enrolled. The participants were randomized to three groups: group 1 (lidocaine spray), in which lidocaine spray was applied thoroughly to the cervix; group 2 (placebo)
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Beyond Tumors: Gastric Syphilis Emulating a Gastric Neoplasia Medicina (IF 2.948) Pub Date : 2024-04-13 Claudia Guerrero Muñoz, Andres Castañeda Agredo, Maria Jose Romero Valle, Andrés Mauricio Silva Silva, Marta León del Campo, Claudia Azpirtarte Sánchez, Marta Domínguez Fraga, Manuel Vicente Milán Pilo, Benjamin Arturo Polo Lorduy, Agustina González Guirado, María Jesus Martín Relloso, Paloma Sánchez-Fayos Calabuig, Orencio Bosch Esteva
We present the case of a 35-year-old male with a first-degree family history of gastric cancer (his father was diagnosed at the age of 45), who was presumed to have gastric cancer himself when evaluating the features of his upper endoscopy performed after hematemesis. Surprisingly, no cancer cells were found in the biopsies. Thanks to a different diagnostic suspicion subsequent to performing a full
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Systematic Review and Meta-Analysis on Optimal Timing of Surgery for Acute Symptomatic Metastatic Spinal Cord Compression Medicina (IF 2.948) Pub Date : 2024-04-13 Nicola Bresolin, Luca Sartori, Giacomo Drago, Giulia Pastorello, Paolo Gallinaro, Jacopo Del Verme, Roberto Zanata, Enrico Giordan
Introduction: Symptomatic acute metastatic spinal epidural cord compression (MSCC) is an emergency that requires multimodal attention. However, there is no clear consensus on the appropriate timing for surgery. Therefore, to address this issue, we conducted a systematic review and meta-analysis of the literature to evaluate the outcomes of different surgery timings. Methods: We searched multiple databases
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Pancreaticoduodenectomy with Anatomical Vascular Variant in Groove Pancreatitis—A Case Report Medicina (IF 2.948) Pub Date : 2024-04-12 Gelu M. Breaza, Radu G. Dan, Florin E. Hut, Flavia Baderca, Octavian M. Cretu, Laurentiu V. Sima
Groove pancreatitis represents a chronic focal form of pancreatitis affecting the zone between the pancreatic head and the duodenal “C” loop, known as the groove area. This is a rare condition that affects the pancreatic periampullary part, including the duodenum and the common bile duct, which is usually associated with long-term alcohol and tobacco misuse, and is more frequent in men than in women
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The Effect of Shift Working on Dietary Patterns of Healthcare Practitioners during the COVID-19 Pandemic: A Cross-Sectional Study Medicina (IF 2.948) Pub Date : 2024-04-12 Athanasios Migdanis, Konstantinos Tsolis, Ioannis Migdanis, Agoritsa G. Kaltsa, Fotios A. Fytsilis, Athanasios Manouras, Odysseas Androutsos, Andreas Kapsoritakis
Background and Objectives: Health professionals’ working schedules often do not allow them to follow a balanced way of life, and the nature of their work can affect their weight and eating habits. The aim of the present study is to shed some light on the impact of night shift working on the dietary practices of healthcare practitioners in Greece. Materials and Methods: This was a cross-sectional study
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Association between Periodontal Disease and Obesity: Umbrella Review Medicina (IF 2.948) Pub Date : 2024-04-11 Heber Isac Arbildo-Vega, Fredy Hugo Cruzado-Oliva, Franz Tito Coronel-Zubiate, Rubén Aguirre-Ipenza, Joan Manuel Meza-Málaga, Sara Antonieta Luján-Valencia, Eduardo Luján-Urviola, Carlos Alberto Farje-Gallardo
Objective: Determine the association between periodontal disease (PD) and obesity through an umbrella review. Materials and Methods: A search for information until March 2024 was carried out in the following electronic databases: PubMed, Cochrane library, Scopus, SciELO, Web of Science, Google Scholar, Proquest Dissertations and Theses, and OpenGrey. We included studies that were systematic reviews
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Meditation Moderates the Relationship between Insecure Attachment and Loneliness: A Study of Long-Term Care Residents in Thailand Medicina (IF 2.948) Pub Date : 2024-04-11 Khin Moe Myint, Justin DeMaranville, Tinakon Wongpakaran, Carmelle Peisah, Suthikarn Arunrasameesopa, Nahathai Wongpakaran
Background and Objectives: Loneliness is prevalent among residents of long-term care settings, posing significant challenges to their mental wellbeing. Insecure attachment has been identified as a contributing factor to loneliness in this population. Previous research has suggested that meditation may have beneficial effects on mental health outcomes. This study aimed to examine the relationship between
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Influence of Health Insurance Types on Clinical Cancer Care Accessibility and Quality Using All of Us Database Medicina (IF 2.948) Pub Date : 2024-04-11 Sedra Tibi, Vivian Tieu, Suat Babayigit, Jun Ling
Background and Objectives: Cancer, as the second leading cause of death in the United States, poses a huge healthcare burden. Barriers to access to advanced therapies influence the outcome of cancer treatment. In this study, we examined whether insurance types affect the quality of cancer clinical care. Materials and Methods: Data for 13,340 cancer patients with Purchased or Medicaid insurance from
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Time Is Life: Golden Ten Minutes on Scene–EuReCa_Serbia 2014–2023 Medicina (IF 2.948) Pub Date : 2024-04-11 Suzana Randjelovic, Srdjan Nikolovski, Dragica Selakovic, Miodrag Sreckovic, Sara Rosic, Gvozden Rosic, Violetta Raffay
Background and Objectives: This study analyzed the frequency of factors influencing the course and outcomes of out-of-hospital cardiac arrest (OHCA) in Serbia and the prediction of pre-hospital outcomes and survival. Materials and Methods: Data were collected during the period from 1 October 2014, to 31 September 2023, according to the protocol of the EuReCa_One study (clinical trial ID number NCT02236819)
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Predictive Model of Recovery to Prefracture Activities-of-Daily-Living Status One Year after Fragility Hip Fracture Medicina (IF 2.948) Pub Date : 2024-04-09 Nitchanant Kitcharanant, Pichitchai Atthakomol, Jiraporn Khorana, Phichayut Phinyo, Aasis Unnanuntana
Background and Objectives: Achieving prefracture functional status is a critical objective following a hip fracture, yet fewer than half of patients reach this milestone. The adoption of tools for assessing functional outcomes is increasingly recognized as essential for evaluating recovery following treatment for fragility hip fractures. We developed multivariable clinical prediction criteria to estimate
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Correlation between Radiological Characteristics, PET-CT and Histological Subtypes of Primary Lung Adenocarcinoma—A 102 Case Series Analysis Medicina (IF 2.948) Pub Date : 2024-04-10 Nikola Colic, Ruza Stevic, Mihailo Stjepanovic, Milan Savić, Jelena Jankovic, Slobodan Belic, Jelena Petrovic, Nikola Bogosavljevic, Dejan Aleksandric, Katarina Lukic, Marko Kostić, Dusan Saponjski, Jelena Vasic Madzarevic, Stefan Stojkovic, Maja Ercegovac, Zeljko Garabinovic
Background and Objectives: Lung cancer is the second most common form of cancer in the world for both men and women as well as the most common cause of cancer-related deaths worldwide. The aim of this study is to summarize the radiological characteristics between primary lung adenocarcinoma subtypes and to correlate them with FDG uptake on PET-CT. Materials and Methods: This retrospective study included
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A Novel Technique for Basilar Invagination Treatment in a Patient with Klippel–Feil Syndrome: A Clinical Example and Brief Literature Review Medicina (IF 2.948) Pub Date : 2024-04-10 Masato Tanaka, Abd El Kader Al Askar, Chetan Kumawat, Shinya Arataki, Tadashi Komatsubara, Takuya Taoka, Koji Uotani, Yoshiaki Oda
Objectives and Background: To present a novel technique of treatment for a patient with basilar invagination. Basilar invagination (BI) is a congenital condition that can compress the cervicomedullary junction, leading to neurological deficits. Severe cases require surgical intervention, but there is debate over the choice of approach. The anterior approach allows direct decompression but carries high
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Understanding CEAP Classification: Insights from an Italian Survey on Corona Phlebectatica and Recurrent Active Venous Ulcers by Vascular Specialists Medicina (IF 2.948) Pub Date : 2024-04-10 Gianfranco Lessiani, Luca Gazzabin, Giulio Cocco, Antonio Corvino, Damiano D’Ardes, Andrea Boccatonda
Background and Objectives: The clinical relevance of “corona phlebectatica” and the management of risk factors for recurrence of venous ulcers in patients with chronic venous disease may be variable based on vascular specialists in different geographical areas of Italy. The aim of the present survey is to evaluate the management of patients with chronic venous disease by vascular specialists in different
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Prediction of a Difficult Airway Using the ARNE Score and Flexible Laryngoscopy in Patients with Laryngeal Pathology Medicina (IF 2.948) Pub Date : 2024-04-10 Danica Marković, Maja Šurbatović, Dušan Milisavljević, Vesna Marjanović, Biljana Stošić, Milan Stanković
Background and Objectives: The ARNE score was developed for the prediction of a difficult airway for both general and ear, nose and throat (ENT) surgery with a universal cut-off value. We tested the accuracy of this score in the case of laryngeal surgery and provided an insight into its effects in combination with flexible laryngoscopy. Materials and Methods: This prospective pilot clinical study included
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A Comprehensive Review: Robot-Assisted Treatments for Gait Rehabilitation in Stroke Patients Medicina (IF 2.948) Pub Date : 2024-04-10 Yong-Hwa Park, Dae-Hwan Lee, Jung-Ho Lee
Robot-assisted gait training (RAGT) is at the cutting edge of stroke rehabilitation, offering a groundbreaking method to improve motor recovery and enhance the quality of life for stroke survivors. This review investigates the effectiveness and application of various RAGT systems, including both end-effector and exoskeleton robots, in facilitating gait enhancements. The selection process for this comprehensive
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Application of Salivary Alpha-1 Antitrypsin in the Diagnosis of Rheumatoid Arthritis: A Pilot Study Medicina (IF 2.948) Pub Date : 2024-04-06 Sang Wan Chung, Seung-Jae Hong
Background and Objective: Rheumatoid arthritis (RA) is an autoimmune disease in which joints are gradually destroyed. Early diagnosis and treatment before joint deformation or destruction is important. The detection of novel RA biomarkers in saliva may facilitate early detection of RA before disease onset. This study aimed to evaluate salivary concentration of α1-antitrypsin (A1AT) in healthy patients
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Differential Protective Effect of Zinc and Magnesium for the Hepatic and Renal Toxicity Induced by Acetaminophen and Potentiated with Ciprofloxacin in Rats Medicina (IF 2.948) Pub Date : 2024-04-08 Alexandra Ciocan (Moraru), Diana Ciubotariu, Cristina Mihaela Ghiciuc, Mihnea Eudoxiu Hurmuzache, Cătălina Elena Lupușoru, Radu Crișan-Dabija
Background and Objectives: The purpose of this study was to investigate the influence induced by magnesium chloride (MgCl2) and zinc gluconate (ZnG) supplementation on liver and kidney injuries experimentally induced with acetaminophen (AAPh) and potentiated by a ciprofloxacin addition in rats. Material and Methods: The experiment was performed on five animal groups: group 1—control, treated for 6
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Postoperative Pain Following Eye Enucleation: A Prospective Observational Study Medicina (IF 2.948) Pub Date : 2024-04-09 Nicolas Leister, Johannes Löser, Antoniu-Oreste Gostian, Magdalena Gostian, Alexander C. Rokohl, Marc A. Fieber, Deniz Alkan, Christine Schumacher, Vanessa Löw, Erik Gordon, Bernd W. Böttiger, Ludwig M. Heindl
Background and Objectives: Enucleation of an eye is the most invasive procedure in ophthalmologic surgery. It can be the result of various diseases (malignant/chronic/trauma/infection) and is nevertheless relatively rare, but leads to the loss of a strongly innervated neuronal organ. This study systematically evaluates postoperative pain levels following enucleation of the eye globe. Materials and
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A Narrative Review of Psychobiotics: Probiotics That Influence the Gut–Brain Axis Medicina (IF 2.948) Pub Date : 2024-04-05 Laima Ķimse, Aigars Reinis, Lāsma Miķelsone-Jansone, Sandra Gintere, Angelika Krūmiņa
Mental health disorders and dementia have become a serious public health concern, with a heightened frequency of diagnoses observed in the wake of the global COVID-19 pandemic. Psychobiotics, a novel area of research at the intersection of microbiology and neuroscience, explore the potential of probiotics to influence the nervous system and mental health outcomes. This review explores the intricate
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Assessing the Diagnostic Values of the Neutrophil-to-Lymphocyte Ratio (NLR) and Systematic Immunoinflammatory Index (SII) as Biomarkers in Predicting COVID-19 Severity: A Multicentre Comparative Study Medicina (IF 2.948) Pub Date : 2024-04-05 Anwar A. Sayed
COVID-19 has been notoriously unpredictable in its clinical course. Such unpredictability poses a challenge to clinicians in predicting patients who will develop severe cases and possibly die from the infection. This study aims to assess and compare the diagnostic value of the NLR and SII as biomarkers in predicting COVID-19 severity, represented by mortality, with a multicentre comparative study including
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Aesthetic Rehabilitation Medicine: Enhancing Wellbeing beyond Functional Recovery Medicina (IF 2.948) Pub Date : 2024-04-05 Lorenzo Lippi, Martina Ferrillo, Luigi Losco, Arianna Folli, Marco Marcasciano, Claudio Curci, Stefano Moalli, Antonio Ammendolia, Alessandro de Sire, Marco Invernizzi
Although rehabilitation medicine emphasizes a holistic health approach, there is still a large gap of knowledge about potential interventions aimed at improving overall wellbeing through cosmetic interventions. Therefore, this narrative review investigates the role of different rehabilitative techniques in enhancing aesthetics, quality of life, and psychosocial wellbeing for patients with disabilities