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Extracellular vesicle-mediated transfer of miRNA-1 from primary tumors represses the growth of distant metastases Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-27 Chae-Yi Kim, Kang-Hoon Lee, Keun Hong Son, Tae-Jin Shin, Je-Yoel Cho
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Involvement of DJ-1 in the pathogenesis of intervertebral disc degeneration via hexokinase 2-mediated mitophagy Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-27 Jialiang Lin, Longjie Wang, Yuhao Wu, Qian Xiang, Yongzhao Zhao, Xuanqi Zheng, Shuai Jiang, Zhuoran Sun, Dongwei Fan, Weishi Li
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Acetyl-CoA synthetase 2 contributes to a better prognosis for liver cancer by switching acetate-glucose metabolism Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-25 Kyung Hee Jung, Sujin Lee, Han Sun Kim, Jin-Mo Kim, Yun Ji Lee, Min Seok Park, Myeong-Seong Seo, Misu Lee, Mijin Yun, Sunghyouk Park, Soon-Sun Hong
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Cancer-derived exosomal Alu RNA promotes colorectal cancer progression Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-14 Sara Magliacane Trotta, Antonio Adinolfi, Luca D’Orsi, Sonia Panico, Grazia Mercadante, Patrick Mehlen, Jayakrishna Ambati, Sandro De Falco, Valeria Tarallo
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Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in postmenopausal cardiomyopathy Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-14 Byeong-Yun Ahn, Yan Zhang, Shibo Wei, Yideul Jeong, Dong-Hyun Park, Sang-Jin Lee, Young-Eun Leem, Jong-Sun Kang
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Dysregulated CREB3 cleavage at the nuclear membrane induces karyoptosis-mediated cell death Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-13 Ga-Eun Lee, Geul Bang, Jiin Byun, Cheol-Jung Lee, Weidong Chen, Dohyun Jeung, Hyun-Jung An, Han Chang Kang, Joo Young Lee, Hye Suk Lee, Young-Soo Hong, Dae Joon Kim, Megan Keniry, Jin Young Kim, Jin-Sung Choi, Manolis Fanto, Sung-Jun Cho, Kwang-Dong Kim, Yong-Yeon Cho
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Immunopathology of and potential therapeutics for secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome: a translational perspective Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-06 Tram T. T. Nguyen, Yoon Tae Kim, Geunyeol Jeong, Mirim Jin
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The Mst1/2-BNIP3 axis is required for mitophagy induction and neuronal viability under mitochondrial stress Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-05 Dae Jin Jeong, Jee-Hyun Um, Young Yeon Kim, Dong Jin Shin, Sangwoo Im, Kang-Min Lee, Yun-Hee Lee, Dae-sik Lim, Donghoon Kim, Jeanho Yun
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Rebuilding the microenvironment of primary tumors in humans: a focus on stroma Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-05 Siwon Mun, Hyun Jin Lee, Pilnam Kim
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SIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-05 Ji An Kang, Yoon Jung Kim, Kyu Yun Jang, Hye Won Moon, Haeseung Lee, Seonjeong Lee, Hyun Kyu Song, Sang Woo Cho, Yoon Sun Yoo, Hye Gyeong Han, Min-Ju Kim, Myoung Ja Chung, Cheol Yong Choi, Cheolju Lee, Chaeuk Chung, Gang Min Hur, You-Sun Kim, Young Joo Jeon
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Extramedullary hematopoiesis in cancer Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-05 Derek A. G. Barisas, Kyunghee Choi
Hematopoiesis can occur outside of the bone marrow during inflammatory stress to increase the production of primarily myeloid cells at extramedullary sites; this process is known as extramedullary hematopoiesis (EMH). As observed in a broad range of hematologic and nonhematologic diseases, EMH is now recognized for its important contributions to solid tumor pathology and prognosis. To initiate EMH
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Advances in single-cell omics and multiomics for high-resolution molecular profiling Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-05 Jongsu Lim, Chanho Park, Minjae Kim, Hyukhee Kim, Junil Kim, Dong-Sung Lee
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Advances in cancer DNA methylation analysis with methPLIER: use of non-negative matrix factorization and knowledge-based constraints to enhance biological interpretability Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-04 Ken Takasawa, Ken Asada, Syuzo Kaneko, Kouya Shiraishi, Hidenori Machino, Satoshi Takahashi, Norio Shinkai, Nobuji Kouno, Kazuma Kobayashi, Masaaki Komatsu, Takaaki Mizuno, Yu Okubo, Masami Mukai, Tatsuya Yoshida, Yukihiro Yoshida, Hidehito Horinouchi, Shun-Ichi Watanabe, Yuichiro Ohe, Yasushi Yatabe, Takashi Kohno, Ryuji Hamamoto
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Intestinal stem cells: guardians of homeostasis in health and aging amid environmental challenges Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-01 Jiahn Choi, Leonard H. Augenlicht
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RNA m5C modification upregulates E2F1 expression in a manner dependent on YBX1 phase separation and promotes tumor progression in ovarian cancer Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-01 Xiaoyi Liu, Qinglv Wei, Chenyue Yang, Hongyan Zhao, Jie Xu, Youchaou Mobet, Qingya Luo, Dan Yang, Xinzhao Zuo, Ningxuan Chen, Yu Yang, Li Li, Wei Wang, Jianhua Yu, Jing Xu, Tao Liu, Ping Yi
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Synergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-01 Jihoon G. Yoon, Dong Geon Jang, Sung-Gyu Cho, Chaeyoung Lee, Shin Hye Noh, Soo Kyung Seo, Jung Woo Yu, Hyeon Woo Chung, KyeoRe Han, Soon Sung Kwon, Dai Hoon Han, Jaeseong Oh, In-Jin Jang, Sang-Hoon Kim, Young-Koo Jee, Hyun Lee, Dong Won Park, Jang Won Sohn, Ho Joo Yoon, Chul Hoon Kim, Jae Myun Lee, Sang-Heon Kim, Min Goo Lee
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IL-27-induced PD-L1highSca-1+ innate lymphoid cells suppress contact hypersensitivity in an IL-10-dependent manner Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-01 Keun Young Min, Do-Kyun Kim, Min Geun Jo, min Yeong Choi, Dajeong Lee, Jeong Won Park, Young-Jun Park, Yeonseok Chung, Young Mi Kim, Yeong-Min Park, Hyuk Soon Kim, Wahn Soo Choi
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Hypoxia, oxidative stress, and the interplay of HIFs and NRF2 signaling in cancer Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-01 Taegeun Bae, Steffanus Pranoto Hallis, Mi-Kyoung Kwak
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Mechanical overload-induced release of extracellular mitochondrial particles from tendon cells leads to inflammation in tendinopathy Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-01 Ziming Chen, Mengyuan Li, Peilin Chen, Andrew Tai, Jiayue Li, Euphemie Landao Bassonga, Junjie Gao, Delin Liu, David Wood, Brendan F. Kennedy, Qiujian Zheng, Ming H. Zheng
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Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop Exp. Mol. Med. (IF 12.8) Pub Date : 2024-03-01 Sheng Yang, JiaJun Xie, ZhiJie Pan, HongMei Guan, YueSheng Tu, YuanJian Ye, ShouBin Huang, ShiQiang Fu, KangXian Li, ZhiWei Huang, XiaoQi Li, ZhanJun Shi, Le Li, Yang Zhang
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Role of lung ornithine aminotransferase in idiopathic pulmonary fibrosis: regulation of mitochondrial ROS generation and TGF-β1 activity Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-28 Jong-Uk Lee, Ki Sung Song, Jisu Hong, Hyesun Shin, Eunji Park, Junyeong Baek, Shinhee Park, Ae-Rin Baek, Junehyuk Lee, An Soo Jang, Do Jin Kim, Su Sie Chin, U-Jin Kim, Sung Hwan Jeong, Sung-Woo Park
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Cost and time-efficient construction of a 3′-end mRNA library from unpurified bulk RNA in a single tube Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-27 Jungwon Choi, Jungheun Hyun, Jieun Hyun, Jae-Hee Kim, Ji Hyun Lee, Duhee Bang
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NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-27 Hye Yeon Choi, Yicheng Zhu, Xuyao Zhao, Simran Mehta, Juan Carlos Hernandez, Jae-Jin Lee, Yi Kou, Risa Machida, Mauro Giacca, Giannino Del Sal, Ratna Ray, Hyungjin Eoh, Stanley M. Tahara, Lin Chen, Hidekazu Tsukamoto, Keigo Machida
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Baf-mediated transcriptional regulation of teashirt is essential for the development of neural progenitor cell lineages Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-19 Byung Su Ko, Myeong Hoon Han, Min Jee Kwon, Dong Gon Cha, Yuri Ji, Eun Seo Park, Min Jae Jeon, Somi Kim, Kyeongho Lee, Yoon Ha Choi, Jusung Lee, Monica Torras-Llort, Ki-Jun Yoon, Hyosang Lee, Jong Kyoung Kim, Sung Bae Lee
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Helicobacter pylori CagA-mediated ether lipid biosynthesis promotes ferroptosis susceptibility in gastric cancer Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-21 Yanmei Peng, Xuetao Lei, Qingbin Yang, Guofan Zhang, Sixiao He, Minghao Wang, Ruoyu Ling, Boyang Zheng, Jiayong He, Xinhua Chen, Fengping Li, Qiming Zhou, Liying Zhao, Gengtai Ye, Guoxin Li
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Distinct characteristics of the DNA damage response in mammalian oocytes Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-14 Jiyeon Leem, Crystal Lee, Da Yi Choi, Jeong Su Oh
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Emerging roles of MITF as a crucial regulator of immunity Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-13 Aram Lee, Jihyun Lim, Jong-Seok Lim
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Acid sphingomyelinase as a pathological and therapeutic target in neurological disorders: focus on Alzheimer’s disease Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-09 Byung Jo Choi, Min Hee Park, Hee Kyung Jin, Jae-sung Bae
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Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-05 Shuo Tian, Xuanzuo Chen, Wei Wu, Hui Lin, Xiangcheng Qing, Sheng Liu, BaiChuan Wang, Yan Xiao, Zengwu Shao, Yizhong Peng
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The deubiquitinase USP40 preserves endothelial integrity by targeting the heat shock protein HSP90β Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-02 Jiaxing Miao, Lian Li, Nargis Shaheen, Jianxin Wei, Anastasia M. Jacko, Prithu Sundd, Sarah J. Taleb, Rama K. Mallampalli, Yutong Zhao, Jing Zhao
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Regulation of autophagy by perilysosomal calcium: a new player in β-cell lipotoxicity Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-01 Ha Thu Nguyen, Andreas Wiederkehr, Claes B. Wollheim, Kyu-Sang Park
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Role of UPF1 in lncRNA-HEIH regulation for hepatocellular carcinoma therapy Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-01 Hyunho Cha, Minwoo Kim, Narae Ahn, Seong Dong Jeong, Elizaveta Ignatova, Sung Wook Chi, Hyeon Ho Kim, Jungwook Hwang
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Exploring the potential of Toxoplasma gondii in drug development and as a delivery system Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-01 Chanjin Yoon, Yu Seong Ham, Woo Jin Gil, Chul-Su Yang
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Synaptotagmin-4 induces anhedonic responses to chronic stress via BDNF signaling in the medial prefrontal cortex Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-01 Jeongseop Kim, Sihwan Seol, Tae-Eun Kim, Joonhee Lee, Ja Wook Koo, Hyo Jung Kang
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Cathepsin D promotes polarization of tumor-associated macrophages and metastasis through TGFBI-CCL20 signaling Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-01 Seul Gi Lee, Seon Min Woo, Seung Un Seo, Chan-Hyeong Lee, Moon-Chang Baek, Se Hwan Jang, Zee Yong Park, Simmyung Yook, Ju-Ock Nam, Taeg Kyu Kwon
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Targeting the m6A RNA methyltransferase METTL3 attenuates the development of kidney fibrosis Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-01 Hae Rim Jung, Jeonghwan Lee, Seung-Pyo Hong, Nayeon Shin, Ara Cho, Dong-Jin Shin, Jin Woo Choi, Jong-Il Kim, Jung Pyo Lee, Sung-Yup Cho
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Unraveling the intricacies of osteoclast differentiation and maturation: insight into novel therapeutic strategies for bone-destructive diseases Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-01 Noriko Takegahara, Hyunsoo Kim, Yongwon Choi
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HIRA vs. DAXX: the two axes shaping the histone H3.3 landscape Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-01 Jinmi Choi, Taewan Kim, Eun-Jung Cho
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Deficiency of circadian clock gene Bmal1 exacerbates noncanonical inflammasome-mediated pyroptosis and lethality via Rev-erbα-C/EBPβ-SAA1 axis Exp. Mol. Med. (IF 12.8) Pub Date : 2024-02-01 Do-Wan Shim, Jun-Cheol Eo, Saeyoung Kim, Inhwa Hwang, BoYoung Nam, Jae-Eun Shin, Seung Hyeok Han, Je-Wook Yu
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CYB5R3 functions as a tumor suppressor by inducing ER stress-mediated apoptosis in lung cancer cells via the PERK-ATF4 and IRE1α-JNK pathways Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-22 Joo-Young Im, Soo Jin Kim, Jong-Lyul Park, Tae-Hee Han, Woo-il Kim, Inhyub Kim, Bomin Ko, So-Young Chun, Mi-Jung Kang, Bo-Kyung Kim, Sol A. Jeon, Seon-Kyu Kim, Incheol Ryu, Seon-Young Kim, Ki-Hoan Nam, Inah Hwang, Hyun Seung Ban, Misun Won
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PRKCSH contributes to TNFSF resistance by extending IGF1R half-life and activation in lung cancer Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-10 Gu-Choul Shin, Hyeong Min Lee, Nayeon Kim, Sang-Uk Seo, Kwang Pyo Kim, Kyun-Hwan Kim
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The multifaceted functions of β-arrestins and their therapeutic potential in neurodegenerative diseases Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-11 Teresa R. Kee, Sophia A. Khan, Maya B. Neidhart, Brianna M. Masters, Victoria K. Zhao, Yenna K. Kim, Kyle C. McGill Percy, Jung-A A. Woo
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Maintaining Drosha expression with Cdk5 inhibitors as a potential therapeutic strategy for early intervention after TBI Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-10 Lu Huang, Li Xia, Tiejian Nie, Bozhou Cui, Jianjun Lu, Fangfang Lu, Feiyan Fan, Dongni Ren, Yuan Lu, Guodong Gao, Qian Yang
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The polyol pathway and nuclear ketohexokinase A signaling drive hyperglycemia-induced metastasis of gastric cancer Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-10 Ye-Lim Kang, Jiyoung Kim, Su-Bin Kwak, Yi-Sook Kim, June Huh, Jong-Wan Park
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Effects of fine particulate matter on bone marrow-conserved hematopoietic and mesenchymal stem cells: a systematic review Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-10 Govinda Bhattarai, Saroj Kumar Shrestha, Hyun-Jaung Sim, Jeong-Chae Lee, Sung-Ho Kook
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Deciphering the molecular mechanisms of stem cell dynamics in hair follicle regeneration Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-05 Jung Hyun Lee, Sekyu Choi
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Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-05 Eun-Ji Park, Chang-Woo Lee
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Significance of chitinase-3-like protein 1 in the pathogenesis of inflammatory diseases and cancer Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-04 Ji Eun Yu, In Jun Yeo, Sang-Bae Han, Jaesuk Yun, Bongcheol Kim, Yoon Ji Yong, Young-soo Lim, Tae Hun Kim, Dong Ju Son, Jin Tae Hong
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Vitamin D ameliorates age-induced nonalcoholic fatty liver disease by increasing the mitochondrial contact site and cristae organizing system (MICOS) 60 level Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-04 Gyu Hee Kim, Hyeon-Ju Jeong, Yoo Jeong Lee, Hyeon Young Park, Soo Kyung Koo, Joo Hyun Lim
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Modification of immune cell-derived exosomes for enhanced cancer immunotherapy: current advances and therapeutic applications Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-04 Inseong Jung, Sanghee Shin, Moon-Chang Baek, Kyungmoo Yea
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Pathological phenotypes of astrocytes in Alzheimer’s disease Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-04 Junhyung Kim, Ik Dong Yoo, Jaejoon Lim, Jong-Seok Moon
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4-1BB immunotherapy: advances and hurdles Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-04 Rohit Singh, Young-Ho Kim, Sang-Jin Lee, Hyeon-Seok Eom, Beom K. Choi
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Multifaceted roles of CCAR family proteins in the DNA damage response and cancer Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-04 D. Lugano, L. Barrett, S. D. Westerheide, Y. Kee
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Current understanding of the Alzheimer’s disease-associated microbiome and therapeutic strategies Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-04 Dong-oh Seo, David M. Holtzman
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Mitochondria as secretory organelles and therapeutic cargos Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-04 Joonho Suh, Yun-Sil Lee
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Relevance of the endoplasmic reticulum-mitochondria axis in cancer diagnosis and therapy Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-04 Garam An, Junho Park, Jisoo Song, Taeyeon Hong, Gwonhwa Song, Whasun Lim
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WTAP-mediated m6A modification of FRZB triggers the inflammatory response via the Wnt signaling pathway in osteoarthritis Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-04 Xueying An, Rongliang Wang, Zhongyang Lv, Wenshu Wu, Ziying Sun, Rui Wu, Wenjin Yan, Qing Jiang, Xingquan Xu
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Elevated expression of WSB2 degrades p53 and activates the IGFBP3-AKT-mTOR-dependent pathway to drive hepatocellular carcinoma Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-04 Xun Li, Cheng-Cheng Zhang, Xiao-Tong Lin, Jie Zhang, Yu-Jun Zhang, Hong-Qiang Yu, Ze-Yu Liu, Yi Gong, Lei-Da Zhang, Chuan-Ming Xie
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Exploring hematopoiesis in zebrafish using forward genetic screening Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-04 Hyemin Song, Unbeom Shin, Uijeong Nam, Yoonsung Lee
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Spatial architectures of somatic mutations in normal prostate, benign prostatic hyperplasia and coexisting prostate cancer Exp. Mol. Med. (IF 12.8) Pub Date : 2024-01-04 Jeesoo Chae, Seung-Hyun Jung, Eun Ji Choi, Jae Woong Kim, Na Yung Kim, Sung Won Moon, Ji Youl Lee, Yeun-Jun Chung, Sug Hyung Lee