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Association of viral loads of influenza A (H3N2) with age and care setting on presentation—a prospective study during the 2022-2023 influenza season in Spain Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-30 Iván Sanz-Muñoz, Javier Sánchez-Martínez, Carla Rodríguez-Crespo, Irene Arroyo-Hernantes, Marta Domínguez-Gil, Silvia Rojo-Rello, Marta Hernández, José M Eiros
The aim of this study was to analyze the viral load (VL) using cycle threshold (Ct) in patients infected with influenza A (H3N2). This prospective study was conducted during the 2022-2023 influenza season in sentinel, non-sentinel, and hospitalized patients of Castilla y León (Spain). Respiratory samples were obtained from nasopharyngeal swabs and analyzed by quantitative reverse transcription-polymerase
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Generalized lymphadenopathy due to Tropheryma whipplei: Thinking outside the box! Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-29 Stig Ree Krüger, Espen Rigby Norvard, Kjersti Wik Larssen, Ursa Maierhofer, Helene Hestmann, Thomas Papathomas
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Prevalence of HTLV-1/2 infection in pregnant women in Central and South America and the Caribbean: a systematic review and meta-analysis Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-22 Juan-Pablo Sánchez-Núñez, Eva de-Miguel-Balsa, Vicente Soriano, Edurado Lorenzo-Garrido, Angel Giménez-Richarte, Silvia Otero-Rodriguez, Juan-Carlos Celis-Salinas, Carmen de-Mendoza, Martin Casapia-Morales, José Manuel Ramos-Rincón
Human T-lymphotropic viruses (HTLV)-1 infection is endemic in many countries of Central and South America and Caribbean (CSA&C). Neither screening nor surveillance programs exist for HTLV-1/2 infection among pregnant women in this region. Neither in Western nations with large migrant flows from HTLV-1/2 endemic regions. Systematic review and meta-analysis of the prevalence of HTLV-1/2 infection among
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Interplay of inflammatory markers and anti-SARS-CoV-2 antibodies in COVID-19 mortality: A prospective cohort study Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-22 Sylvia Mink, Heinz Drexel, Andreas Leiherer, Matthias Frick, Patrick Reimann, Christoph H. Saely, Peter Fraunberger
Despite high global vaccination coverage, it remains unclear how vaccination and anti-SARS-CoV-2 antibodies affect immune responses and inflammation levels in patients with COVID-19. It is further unclear whether the inflammatory response differs depending on antibody levels and whether the combination of antibody and inflammation levels in COVID-19 patients affects mortality rates. We conducted a
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Vaccine-derived yellow fever in an immunocompromised patient on anti-CD20-antibody therapy and its treatment with sofosbuvir Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-21 Tobias Weirauch, Gerrit Burger, Dániel Cadar, Martin Gabriel, Julia Koepsell, Gundolf Schüttfort, Philipp de Leuw, Markus Bickel, Maria J.G.T. Vehreschild, Timo Wolf, Nils Wetzstein
Yellow fever (YF) is a potentially lethal viral hemorrhagic fever that can be prevented with the 17D live attenuated YF vaccine. However, this vaccination can cause severe adverse reactions including vaccine-associated YF. Here, we describe the case of a 32-year-old female who was permanently immunosuppressed with an anti-CD20 antibody due to multiple sclerosis. Following YF vaccination, the patient
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Joint analysis of vaccination effectiveness and antiviral drug effectiveness for COVID-19: a causal inference approach Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-21 Yue Yat Harrison Cheung, Eric Ho Yin Lau, Guosheng Yin, Yun Lin, Jialiang Jiang, Benjamin John Cowling, Kwok Fai Lam
This study aims to estimate the causal effects of oral antivirals and vaccinations in the prevention of all-cause mortality and progression to severe COVID-19 in an integrative setting with both antivirals and vaccinations considered as interventions. We identified hospitalized adult patients (i.e. aged 18 or above) in Hong Kong with confirmed SARS-CoV-2 infection between March 16, 2022, and December
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Incidental diagnosis of mpox virus infection in patients undergoing sexually transmitted infection screening—findings from a study in France Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-21 Sophie Edouard, Céline Boschi, Philippe Colson, Matthieu Million, Pierre-Edouard Fournier, Bernard La Scola, Florence Fenollar
This study aimed to investigate the prevalence of mpox virus (MPXV) infections in the general population consulting for routine sexually transmitted infections (STIs) in our Marseille public hospital. In fact, the recent worldwide MPXV outbreak mainly impacted men who have sex with men and the prevalence of MPXV infections in the general population remains poorly defined. All samples addressed routinely
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Universal antifungal prophylaxis effectively prevents fungal bloodstream infection in pediatric liver transplant recipients: a retrospective real-world study Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-21 Weili Wang, Yangyang Wang, Yuntao Zhang, Wei Zhang, Xueli Bai, Qi Zhang, Tingbo Liang
Fungal bloodstream infection (fBSI) following pediatric liver transplantation presents a significant challenge; however, there remains a paucity of guidance regarding antifungal prophylaxis in this population. This study aimed to evaluate the effectiveness of universal antifungal prophylaxis and propose a desirable strategy. We enrolled 604 pediatric patients who underwent liver transplantation between
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Next-generation vaccines for tropical infectious diseases Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-16 Tammy Allen, Maria Eugenia Castellanos, Paul Giacomin, Nadira D. Karunaweera, Andreas Kupz, Juan Carlos Lol, Dileep Sharma, Suchandan Sikder, Bemnet Tedla, Liza van Eijk, Danica Vojisavljevic, Guangzu Zhao, Saparna Pai
Tropical infectious diseases inflict an unacceptable burden of disease on humans living in developing countries. Although anti-pathogenic drugs have been widely used, they carry a constant threat of selecting for resistance. Vaccines offer a promising means by which to enhance the global control of tropical infectious diseases; however, these have been difficult to develop, mostly because of the complex
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Dynamics of Plasmodium species and genotype diversity in adults with asymptomatic infection in Gabon Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-16 Juliana Inoue, Annika Galys, Miriam Rodi, Dorothea Ekoka Mbassi, Ghyslain Mombo-Ngoma, Ayôla A. Adegnika, Michael Ramharter, Rella Zoleko-Manego, Peter G. Kremsner, Benjamin Mordmüller, Jana Held
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Dynamics of asymptomatic Plasmodium falciparum and Plasmodium vivax infections and their infectiousness to mosquitoes in a low transmission setting of Ethiopia: a longitudinal observational study Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-14 Elifaged Hailemeskel, Surafel K. Tebeje, Jordache Ramjith, Temesgen Ashine, Kjerstin Lanke, Sinknesh W. Behaksra, Tadele Emiru, Tizita Tsegaye, Abrham Gashaw, Soria Kedir, Wakweya Chali, Endashaw Esayas, Temesgen Tafesse, Haile Abera, Mikiyas Gebremichael Bulto, Girma Shumie, Beyene Petros, Hassen Mamo, Chris Drakeley, Endalamaw Gadisa, Teun Bousema, Fitsum G. Tadesse
A 15-month longitudinal study was conducted to determine the duration and infectivity of asymptomatic qPCR-detected and infections in Ethiopia. Total parasite and gametocyte kinetics were determined by molecular methods; infectivity to mosquitoes by repeated membrane feeding assays. Infectivity results were contrasted with passively recruited symptomatic malaria cases. For and infections detected at
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Transformative potential of artificial intelligence on health care and research in Africa Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-13 Moses J. Bockarie, Rashid Ansumana, Shingai Grace Machingaidze, Dziedzom K. de Souza, Patrick Fatoma, Alimuddin Zumla, Shui-Shan Lee
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Prevalence and risk factors of post-coronavirus disease 2019 condition among children and adolescents in Japan: A matched case-control study in the general population Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-13 Mariko Hosozawa, Miyuki Hori, Mina Hayama-Terada, Iba Arisa, Yoko Muto, Akihiko Kitamura, Yoshihiro Takayama, Hiroyasu Iso
To examine prevalence and risk factors for post-COVID-19 condition (PCC) in a paediatric population. The study included patients aged 5-17 years with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection between 1 March 2021 and 30 April 2022 and matched non-infected controls from Yao City, Japan. We compared parent-reported symptoms persisting ≥2 months (present at 3 months post-infection
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A case of leprosy in a nonendemic country Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-11 Erika Asperges, Jessica Bagnarino, Cinzia Ancarani, Ginevra Baggini, Matteo Filardo, Vincenzina Monzillo, Daniela Barbarini, Raffaele Bruno, Marco Paulli, Fausto Baldanti
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Screening for latent tuberculosis in migrants—status quo and future challenges Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-11 Eskild Petersen, Seif Al-Abri, Amina Al-Jardani, Ziad A. Memish, Eleni Aklillu, Francine Ntoumi, Peter Mwaba, Christian Wejse, Alimuddin Zumla, Fatma Al-Yaquobi
To review the evidence that migrants from tuberculosis (TB) high-incidence countries migrating to TB low-incidence countries significantly contribute to active TB cases in the counties of destination, primarily through reactivation of latent TB. This is a narrative review. The different screening programs in the countries of destination are reviewed either based on screening and preventive treatment
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Spatial Heterogeneity of Nontuberculous Mycobacterial Pulmonary Disease in Shanghai: Insights from a Ten-Year Population-Based Study Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-10 Yangyi Zhang, Ruoyao Sun, Chenlei Yu, Jing Li, Honghua Lin, Jinrong Huang, Ying Wang, Xin Shen, Yuan Jiang, Chongguang Yang, Biao Xu
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Invasive Aspergillosis with impaired neutrophil responses against Aspergillus fumigatus in patients treated with Acalabrutinib—findings from three cases Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-08 Marion Blaize, Guillaume Thizy, Alexandre Boissonnas, Anaïs Portalier, Fanny Lanternier, Clémentine de La Porte des Vaux, Felipe Suarez, Marie-Elisabeth Bougnoux, Juliette Guitard, Arnaud Jabet, Nicolas Stocker, Abdelmalek Aoudjhane, Damien Roos-Weil, Arnaud Fekkar
Ibrutinib, a first-generation covalent Bruton's tyrosine kinase inhibitor (BTKi) was found to be a risk factor for the occurrence of invasive fungal complications. Acalabrutinib is a second-generation covalent BTKi used to treat B-cell malignancies. Healthy donor neutrophils incubated with acalabrutinib lose ability to control conidia germination. In patients receiving acalabrutinib, the potential
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Detection of Mycobacterium tuberculosis DNA in CD34+ peripheral blood mononuclear cells of adults with tuberculosis infection and disease Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-07 Federica Repele, Tonino Alonzi, Assunta Navarra, Chiara Farroni, Andrea Salmi, Gilda Cuzzi, Giovanni Delogu, Gina Gualano, Vincenzo Puro, Gabriella De Carli, Enrico Girardi, Fabrizio Palmieri, Adrian R. Martineau, Delia Goletti
To investigate whether (Mtb) DNA is detected in peripheral blood mononuclear cells (PBMC) of subjects with tuberculosis (TB) or TB infection (TBI) living in a low-burden country. We prospectively enrolled 57 patients with TB, 41 subjects with TBI, and 39 controls in Rome, Italy. PBMC were isolated, cluster of differentiation (CD)34 and CD34 cells were immunomagnetic separated, DNA was extracted, and
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Increased circulation of echovirus 11 in the general population and hospital patients as elicited by the non-polio enterovirus laboratory-based sentinel surveillance in northern Italy, 2023 Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-07 Laura Pellegrinelli, Cristina Galli, Federica Giardina, Guglielmo Ferrari, Sara Colonia Uceda Renteria, Ferruccio Ceriotti, Arlinda Seiti, Sandro Binda, Antonino Maria Guglielmo Pitrolo, Roberta Schiavo, Sergio Maria Ivano Malandrin, Annalisa Cavallero, Marco Arosio, Claudio Farina, Massimo Oggioni, Pierluigi Congedo, Danilo Cereda, Francesca Rovida, Antonio Piralla, Elena Pariani, Fausto Baldanti
Following the alert of echovirus 11 (E-11) infection in neonates in EU/EEA Member States, we conducted an investigation of E-11 circulation by gathering data from community and hospital surveillance of enterovirus (EV) in northern Italy from 01 August 2021 to 30 June 2023. Virological results of EVs were obtained from the regional sentinel surveillance database for influenza-like illness (ILI) in outpatients
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Effectiveness of metagenomic next-generation sequencing in the diagnosis of infectious diseases: A systematic review and meta-analysis Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-07 Yusi Liu, Sibei Qin, Chunhai Lan, Qinmiao Huang, Peng Zhang, Weiling Cao
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World Tuberculosis Day 2024 theme “Yes! We can end TB” can be made a reality through concerted global efforts that advance detection, diagnosis, and treatment of tuberculosis infection and disease Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-07 Delia Goletti, Seif Al-Abri, Giovanni Battista Migliori, Cecilia Lindestam Arlehamn, Pranabashis Haldar, Christopher Sundling, Christopher da Costa, Kin Wang To, Adrian R. Martineau, Eskild Petersen, Alimuddin Zumla, Shui Shan Lee
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Pancytopenia following adjuvant therapy with interferon-gamma in a patient with disseminated nocardiosis Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-06 Thomas Derungs, Denis Poddubnyy, Thomas Schneider
A patient with disseminated nocardiosis developed pancytopenia after treatment with recombinant interferon-gamma (IFN-γ). While no previous clinical reports link pancytopenia to IFN-γ, our observations align with basic research on myelosuppressive effects of IFN-γ. Adjunctive IFN-γ may improve standard nocardiosis therapy, but vigilant monitoring of its hematologic effects is necessary.
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Persistent poor clinical outcomes of people living with HIV presenting with AIDS and late HIV diagnosis – results from the ICONA cohort in Italy, 2009-2022 Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-06 Annalisa Mondi, Alessandro Cozzi-Lepri, Alessandro Tavelli, Antonella Cingolani, Andrea Giacomelli, Giancarlo Orofino, Gabriella De Girolamo, Carmela Pinnetti, Andrea Gori, Annalisa Saracino, Alessandra Bandera, Giulia Marchetti, Enrico Girardi, Cristina Mussini, Antonella d'Arminio Monforte, Andrea Antinori, ICONA Foundation Study Group
Limited data are available on the long-term outcomes in recent years for late HIV diagnosis (LD). All subjects with HIV enrolled in the ICONA cohort in 2009-2022 who started antiretroviral treatment (ART) within 4 months from diagnosis were included and divided into: (i) pre-ART CD4 count ≥350/mm without AIDS (non-LD), (ii) pre-ART CD4 count <350/mm without AIDS (LD asymptomatic), and (iii) with AIDS
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Is the new tuberculous antigen-based skin test ready for use as an alternative to tuberculin skin test/interferon-gamma release assay for tuberculous diagnosis? A narrative review Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-06 Kin Wang To, Rui Zhang, Shui Shan Lee
In recent years, novel specific Mycobacteria tuberculous (TB) antigen-based skin test (TBST) has become available for clinical use. The mechanism of TBST is similar to the interferon-gamma release assay (IGRA), making it a potential alternative for identifying latent tuberculous infection (LTBI), especially in subjects with history of bacille Calmette-Guérin vaccination. Three different commercial
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Effectiveness of telemedicine for the prevention of mother-to-child transmission of HIV in low-income and middle-income countries: a systematic review and meta-analysis Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-06 Dantong Li, Shang Ma, Binfei Dang, Huifeng Shi, Yuan Wei, Xiaoli Wang
We aimed to estimate the effectiveness of telemedicine for the prevention of mother-to-child transmission (PMTCT) program of HIV in low- and middle-income countries (LMICs). We did a systematic literature search of 15 databases for articles published from database inception to October 26, 2022, and performed meta-analyses to estimate the pooled risk ratio of intervention effect (RR) and its 95% confidence
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Corrigendum to “Extensive transmission of SARS-CoV-2 BQ.1* variant in a population with high levels of hybrid immunity: A prevalence survey” [International Journal of Infectious Diseases 139 (2024) 159-167] Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-06 Juan P. Aguilar Ticona, Meng Xiao, Dan Li, Jr. Nivison Nery, Matt Hitchings, Emilia M.M. Andrade Belitardo, Mariam O. Fofana, Renato Victoriano, Jaqueline S. Cruz, Laise de Moraes, Icaro Morais Strobel, Jessica Jesus Silva, Ananias Sena do Aragão Filho, Guilherme S. Ribeiro, Mitermayer G. Reis, Federico Costa, Ricardo Khouri, Albert I. Ko, Derek A.T. Cummings
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Heavily treatment-experienced persons living with HIV currently in care in Italy: characteristics, risk factors, and therapeutic options—the ICONA Foundation cohort study Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-05 Sergio Lo Caputo, Mariacristina Poliseno, Alessandro Tavelli, Roberta Gagliardini, Stefano Rusconi, Giuseppe Lapadula, Andrea Antinori, Daniela Francisci, Loredana Sarmati, Andrea Gori, Vincenzo Spagnuolo, Francesca Ceccherini-Silberstein, Antonella d'Arminio Monforte, Alessandro Cozzi-Lepri, the ICONA Foundation Study Group
Heavily treatment-experienced (HTE) people living with HIV (PLWH) pose unique challenges due to limited antiretroviral treatment (ART) options. Our study aimed to investigate the prevalence and features of HTE individuals followed up in the Italian Cohort Naïve Antiretrovirals (ICONA) cohort as of December 31, 2021. HTE were defined based on meeting specific conditions concerning their current ART
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HIV-1 Tat is present in the serum of people living with HIV-1 despite viral suppression Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-04 Anna Shmakova, Ivan Tsimailo, Yana Kozhevnikova, Laurence Gérard, David Boutboul, Eric Oksenhendler, Edouard Tuaillon, Aurélie Rivault, Diego Germini, Yegor Vassetzky, Bruno Beaumelle
Despite successful human immunodeficiency virus (HIV) control with combination antiretroviral therapy (cART), individuals with HIV still face health risks, including cancers, cardiovascular and neurocognitive diseases. An HIV protein, Tat, is potentially involved in these HIV-related diseases. Previous studies demonstrated circulating Tat in the blood of untreated people with HIV. Here, we measured
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State-of-the-art detection of Mycobacterium tuberculosis in blood during tuberculosis infection using phage technology Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-03-04 Catherine ED Rees, Benjamin MC Swift, Pranabashis Haldar
Tuberculosis (TB), an aerosol-transmitted infection caused by (, remains the commonest cause of death globally, from an infectious bacterial disease. Nine years on from the launch of the World Health Organization (WHO)’s END-TB strategy, disease incidence rates are stubbornly unchanged . While this represents, in part, a reversal of improving trends caused by the COVID-19 pandemic, it also reflects
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Post COVID-19 condition imposes significant burden in patients with advanced chronic kidney disease: A nested case-control study Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-28 Pim Bouwmans, S.Reshwan K. Malahe, A. Lianne Messchendorp, Priya Vart, Céline Imhof, Jan-Stephan F. Sanders, Ron T. Gansevoort, Aiko P.J. de Vries, Alferso C. Abrahams, Frederike J. Bemelman, Johanna P.M. Vervoort, Luuk B. Hilbrands, Marc A.G.J. ten Dam, René M.A. van den Dorpel, Theo Rispens, Maurice Steenhuis, Marlies E.J. Reinders, Marc H. Hemmelder, RECOVAC Consortium
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Comparative effectiveness of empirical antibiotic treatments in methicillin-susceptible Staphylococcus aureus infective endocarditis: A post hoc analysis of a prospective French cohort study Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-28 Raphaël Lecomte, Colin Deschanvres, Alexis Bourreau, Louise Ruffier d'Epenoux, Paul Le Turnier, Benjamin Gaborit, Marie Chauveau, Magali Michel, Thierry Le Tourneau, Pascale Bémer, Stéphane Corvec, David Boutoille
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Diagnostic markers reflecting dysregulation of the host response in the transition to tuberculosis disease Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-28 Gunilla Källenius, Margarida Correia-Neves, Christopher Sundling
Sustained control of infection without evidence of disease is based on a finely tuned balance between pro- and anti-inflammatory responses. Loss of this balance leads to tuberculosis (TB) disease, in which exacerbated myeloid and neutrophil activation is common. Proteomic and transcriptomic assessment of the host response can detect increasing immune activation associated with TB disease progression
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SARS-CoV-2 seroprevalence in vaccine-naïve participants from the Democratic Republic of Congo, Guinea, Liberia, and Mali Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-28 Sylvain Laverdure, Donatien Kazadi, Kadidia Kone, Viviane Callier, Djeneba Dabitao, Dehkontee Dennis, Mory Cherif Haidara, Sally Hunsberger, Olivier Tshiani Mbaya, Renee Ridzon, Irini Sereti, Katy Shaw-Saliba, the InVITE Study Team, Esther Akpa, Fatoumata Binta Bah, Yi-Chi Barash, Abdoul Habib Beavogui, Jean-Luc Biampata, Tyler Bonnett, Shawn Brown, Alissa Burkey, Daouda Camara, Sekou Camara, Elfrida
The InVITE study, starting in August 2021, was designed to examine the immunogenicity of different vaccine regimens in several countries including the Democratic Republic of Congo, Guinea, Liberia, and Mali. Pre-vaccination baseline samples were used to obtain estimates of previous SARS-CoV-2 infection in the study population. Adult participants were enrolled upon receipt of their initial COVID-19
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Toward a molecular microbial blood test for tuberculosis infection Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-28 Adrian R. Martineau, Shruthi Chandran, Winnie Palukani, Patricia Garrido, Jonathan Mayito, Stephen T. Reece, Divya Tiwari
The World Health Organization's aim to end the global tuberculosis (TB) epidemic by 2050 cannot be achieved without taking measures to identify people with asymptomatic (Mtb) infection and offer them an intervention to reduce the risk of disease progression, such as preventive antimicrobial therapy. Implementation of this strategy is limited by the fact that existing tests for Mtb infection, which
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Corrigendum to “Recent increased incidence of invasive serogroup W meningococcal disease: A retrospective observational study” [International Journal of Infectious Diseases, 108 (2021), 582-587] Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-26 Nichlas Hovmand, Lene Fogt Lundbo, Gitte Kronborg, Sidsel Skou Voss, Håkon Sandholdt, Steen Hoffmann, Palle Valentiner-Branth, Thomas Benfield
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Corrigendum to “Effectiveness of influenza vaccination on in-hospital death and recurrent hospitalization in older adults with cardiovascular diseases” [International Journal of Infectious Diseases, Volume 122 (2022). Pages 162-168] Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-26 Yuanjie Pang, Xiaofan Liu, Guangqi Liu, Min Lv, Ming Lu, Jiang Wu, Yangmu Huang
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From antigens to immune responses: Shaping the future of TB detection and prevention Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-26 Sudhasini Panda, Kendall Kearns, Catherine Cheng, Cecilia S. Lindestam Arlehamn
Tuberculosis (TB) remains a global health challenge due to various factors, including delayed diagnoses leading to the spread of infection, limited efficacy of current vaccination strategies, and emergence of drug-resistant strains. Here, we explore the significance of ()-specific antigens to overcome these challenges. A narrative review exploring the dynamics of -specific antigens and the related
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Understanding the time-driven shifts of vaccine effectiveness against any and severe COVID-19 before and after the surge of Omicron variants within 2.5 years of vaccination: A meta-regression Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-26 Marek Petráš, Daniela Janovská, Danuše Lomozová, Martina Franklová, Pavel Dlouhý, Jozef Rosina, Ivana Králová Lesná
The COVID-19 pandemic required rapid development of vaccines within a short period of time which did not allow to assess vaccine effectiveness (VE) in the long-term. A computerized literature search was undertaken to identify eligible studies, with no language restrictions, published between 1 December 2020 and 30 June 2023. Out of a total of 27,597 publications, 761 studies were included. Early VE
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Perspectives on development and advancement of new tuberculosis vaccines Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-26 Christopher da Costa, Christine S. Benn, Thomas Nyirenda, Evans Mpabalwani, Harleen M.S. Grewal, Rizwan Ahmed, Nathan Kapata, Peter S. Nyasulu, Markus Maeurer, David S. Hui, Delia Goletti, Alimuddin Zumla
Tuberculosis (TB) remains a leading cause of death worldwide and is estimated to have caused 1.3 million deaths worldwide in 2022. Approximately one quarter of the world's population are infected with , of whom up to 10% will progress to developing active TB disease. Achieving the World Health Organization End TB Strategy targets of a 95% reduction in TB mortality and a 90% reduction in TB incidence
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Interferon-gamma release assay conversion after Mycobacterium tuberculosis exposure specifically associates with greater risk of progression to tuberculosis: A prospective cohort study in Leicester, UK Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-24 Jee Whang Kim, Joshua Nazareth, Joanne Lee, Hemu Patel, Gerrit Woltmann, Raman Verma, Anne O'Garra, Pranabashis Haldar
We investigated whether quantifying the serial QuantiFERON-TB Gold (QFT) response improves tuberculosis (TB) risk stratification in pulmonary TB (PTB) contacts. A total of 297 untreated adult household PTB contacts, QFT tested at baseline and 3 months after index notification, were prospectively observed (median 1460 days). Normal variance of serial QFT responses was established in 46 extrapulmonary
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PASS to End TB in Europe: Accelerated efforts on prevention and systematic screening to end tuberculosis in the WHO European Region by 2030 Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-23 Andrei Dadu, Askar Yedilbayev, Giovanni Battista Migliori, Sevim Ahmedov, Dennis Falzon, Saskia den Boon, Avinash Kanchar, Alberto Matteelli
Outline the objectives, methods, and initial stages of the Prevention and Systematic Screening (PASS) initiative, a complimentary element of the innovative new approach of technical assistance mechanisms of WHO and its partners to countries aligned to the Regional TB Action Plan to End TB in the European Region by 2030. To provide an objective and critical overview of the existing landscape on TB epidemic
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Pumice Stone Sign: Emphysematous Osteomyelitis in Diabetic Ketoacidosis Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-23 Tan Wei Chuan, Samuel Chuan Xian Lau, Lim Yi Ting
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Cefazolin vs cloxacillin in MSSA endocarditis: too good to be true? Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-23 David Tijmen Paulus Buis
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Cefazolin versus cloxacillin in methicillin-susceptible Staphylococcus aureus endocarditis: Too good to be true? Authors’ reply Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-22 Laura Herrera-Hidalgo, Arístides de Alarcón
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Does the healthy vaccinee bias rule them all? Association of COVID-19 vaccination status and all-cause mortality from an analysis of data from 2.2 million individual health records Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-22 Tomáš Fürst, Angelika Bazalová, Tadeáš Fryčák, Jaroslav Janošek
We investigated the validity of claims of the healthy vaccinee effect (HVE) in COVID-vaccine studies by analyzing associations between all-cause mortality (ACM) and COVID-19 vaccination status. Approximately 2.2 million individual records from two Czech health insurance companies were retrospectively analyzed. Each age group was stratified according to the vaccination status (unvaccinated vs. individuals
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Doxycycline post-exposure prophylaxis could theoretically select for resistance to various antimicrobials in 19 pathobionts: an in silico analysis Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-21 Chris Kenyon
Doxycycline post exposure prophylaxis (PEP) has been shown to reduce the incidence of bacterial STIs. However, if there is genetic linkage between resistance to tetracycline and other antimicrobials, then it could also select for resistance to these other antimicrobials. We therefore undertook to evaluate if there is an association between the minimum inhibitory concentrations (MICs) of tetracycline
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Cerebrospinal fluid inflammatory markers to differentiate between neonatal bacterial meningitis and sepsis: A prospective study of diagnostic accuracy Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-21 Nina S. Groeneveld, Sabine E. Olie, Douwe H. Visser, Linde Snoek, Diederik van de Beek, Matthijs C. Brouwer, Merijn W. Bijlsma, NOGBS study group:, Rolanda Baars, Ron van Beek, Vincent Bekker, Maartje van den Berg, Geert Jan Blok, Mijke Breukels, Alwin F.J. Brouwer, Luçan C. Delemarre, Anouk Dings, Rienus A. Doedens, Stefan M. van Dorth, Gertjan Driessen, Hester M. Havers, Jojanneke Heidema, Marieke
We evaluated the diagnostic accuracy of cerebrospinal fluid (CSF) inflammatory markers for diagnosing bacterial meningitis in neonates with sepsis and/or meningitis. Cases were identified from a prospective multicenter study including patients aged 0-3 months with Group B Streptococcal (GBS) or culture positive sepsis/meningitis. CSF CXCL10, MDC, IL-6, IL-8, IL-10, TNF- α, MIF, IL-1RA, CXCL13, IL-1β
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Getting to the heart of the matter—are two agents really better than one for the treatment of staphylococcal infective endocarditis? Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-21 James Donnelly, Helene McDermott, Sadhbh Gash, Ciara O'Connor, Karina O'Connell, Sinead O'Donnell, Binu Dinesh, Karen Burns, Fidelma Fitzpatrick
The recently published European Society of Cardiology guidelines for infective endocarditis management recommends daptomycin combination therapy for the treatment of staphylococcal endocarditis in severe penicillin allergy, rather than daptomycin monotherapy. We discuss the evidence base behind this recommendation, highlighting concerns regarding the lack of robust clinical studies, increased cost
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Recurrent and persistent fever after SARS-CoV-2 infection in patients with follicular lymphoma: A case series Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-21 Lixue Huang, Xunliang Tong, Jia Cui, Xiaoman Du, Yixuan Liao, Xiaoming Tan, Yang Ju, Xuefeng Zhong, Wei Zhou, Xiaomao Xu, Yanming Li
Although persistent or recurrent COVID-19 infection is well described in some immunosuppressed patient cohort, to date, there have been no reports of this phenomenon in the context of repeatedly negative SARS-CoV-2 testing in the upper respiratory tract. We reported six patients with follicular lymphoma who developed recurrent symptomatic COVID-19 infection. They tested persistently negative for SARS-CoV-2
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The associations between invasive group A streptococcal disease and infection with influenza, varicella, or hepatitis C viruses: A data linkage study, Victoria, Australia Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-21 Jessie J. Goldsmith, Christy Vu, Ziheng Zhu, Jennifer H. MacLachlan, Tilda N. Thomson, Patricia Therese Campbell, Katherine B. Gibney
To quantify the associations between invasive group A streptococcal disease (iGAS) incidence and influenza, varicella, and chronic hepatitis C virus (HCV). We used individual-level linked data of iGAS cases from Victoria, Australia (2007-2017) to assess associations between these viral infections and iGAS. A self-controlled case series method was used to estimate the relative incidence of iGAS following
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Analytical performances of a point-of-care loop-mediated isothermal amplification assay to detect Group B Streptococcus in intrapartum pregnant women living in the Democratic Republic of the Congo Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-20 Serge Tonen-Wolyec, Noel Labana Otuli, Monde Otsatre-Okuti, Raelle Atenyi-Kasemire, Raphael Dupont, Laurent Bélec
Group B (GBS) is the leading infectious cause of stillbirth and neonatal morbidity and mortality in sub-Saharan Africa. Vaginal and rectovaginal swab samples were obtained from 274 intrapartum pregnant women in the Democratic Republic of the Congo to be analyzed for GBS DNA detection in parallel by the point-of-care BIOSYNEX AMPLIFLASH® GBS assay (Biosynex SA, Illkirch-Graffenstaden, France) and by
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Epidemiological shifts in and impact of COVID-19 on streptococcal toxic shock syndrome in Japan: A genotypic analysis of group A Streptococcus isolates Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-19 Tadayoshi Ikebe, Rumi Okuno, Yumi Uchitani, Takahiro Yamaguchi, Junko Isobe, Emi Maenishi, Yoshimi Date, Hitoshi Otsuka, Yu Kazawa, Shohei Fujita, Ayaka Kobayashi, Mami Takano, Shinya Tsukamoto, Yoshiko Kanda, Makoto Ohnishi, Yukihiro Akeda, The Working Group for Beta-Hemolytic Streptococci in Japan
Streptococcal toxic shock syndrome (STSS) is caused by group A (GAS; ) strains. In Japan, the number of STSS cases has decreased; however, the underlying reason remains unclear. Moreover, information on distribution and prevalence of specific types in STSS cases is scarce. Hence, we investigated the reason for the decreased number of STSS cases in Japan. We genotyped of 526 GAS isolates obtained from
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Real-time genomic epidemiologic investigation of a multispecies plasmid-associated hospital outbreak of NDM-5-producing Enterobacterales infections Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-17 Nathan J. Raabe, Abby L. Valek, Marissa P. Griffith, Emma Mills, Kady Waggle, Vatsala Rangachar Srinivasa, Ashley M. Ayres, Claire Bradford, Hannah M. Creager, Lora L. Pless, Alexander J. Sundermann, Daria Van Tyne, Graham M. Snyder, Lee H. Harrison
New Delhi metallo-β-lactamase (NDM) is an emergent mechanism of carbapenem resistance associated with high mortality and limited treatment options. Because the resistance gene is often carried on plasmids, traditional infection prevention and control (IP&C) surveillance methods and reactive whole genome sequencing (WGS) may not detect plasmid transfer in multispecies outbreaks. Initial outbreak detection
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A case-control study of risk factors for incident hepatitis B virus infection in South African blood donors Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-17 Ute Jentsch, Marion Vermeulen, Karin van den Berg, Ronél Swanevelder, Darryl Creel, Genevieve Jacobs, Jennifer Jay Hemingway-Foday, Cynthia Nyoni, Edward L. Murphy, Brian Custer
Hepatitis B virus (HBV) infection remains a global health problem. Risk factors for HBV infection are usually assessed in prevalent rather than incident infections. To identify demographic and behavioral risks associated with incident HBV among South African blood donors. A case-control study was performed between November 2014 and January 2018. Cases were blood donors testing positive for HBV DNA
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Estimating excess mortality and economic burden of Clostridioides difficile infections and recurrences during 2015-2019: The RECUR England study Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-16 Subrata Ghosh, Ana Antunes, Hanna Rinta-Kokko, Elena Chaparova, Sarah Lay-Flurrie, Aurore Tricotel, Fredrik L. Andersson
To generate real-world evidence on all-cause mortality and economic burden of infections (CDIs) and recurrences (rCDIs) in England. We conducted a cohort study using retrospective data from Clinical Practice Research Datalink linked to Hospital Episode Statistics. Patients diagnosed with CDI in hospital and community settings during 2015-2018 were included and followed for ≥1 year. All-cause mortality
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Influenza-like illness surveillance may underestimate the incidence of respiratory syncytial virus in adult outpatients Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-16 Alexander Domnich, Andrea Orsi, Matilde Ogliastro, Allegra Ferrari, Bianca Bruzzone, Donatella Panatto, Giancarlo Icardi
Although respiratory syncytial virus (RSV) is a leading cause of acute respiratory infections (ARIs), it is unclear which of the case definitions that prompt swab collection predicts RSV best. We aimed to profile RSV-positive adults and to identify possible RSV case definitions. This individual-based pooled analysis was based on influenza-like illness (ILI) surveillance conducted among Italian outpatient
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Acute COVID-19 treatment is not associated with health problems 2 years after hospitalization Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-15 Julia C. Berentschot, L. Martine Bek, Majanka H. Heijenbrok-Kal, Rita J.G. van den Berg-Emons, Gerard M. Ribbers, Joachim G.J.V. Aerts, Merel E. Hellemons, CO-FLOW Collaboration Group
Various mechanisms, such as immune dysregulation, viral reservoir, and auto-immunity, are hypothesized to underlie the pathogenesis of long-term health problems after hospitalization for COVID-19. We aimed to assess the effect of in-hospital COVID-19 treatments on prominent long-term health problems. In this prospective multicenter cohort study, we enrolled patients (age ≥18 years) who had been hospitalized
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Analysis of the effectiveness of combination antimicrobial therapy for Legionnaires' disease: A nationwide inpatient database study Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-15 Satoshi Kutsuna, Hiroyuki Ohbe, Hiroki Matsui, Hideo Yasunaga
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Assessing the temporal and cause-effect relationship between myocarditis and mRNA COVID-19 vaccines. A retrospective observational study Int. J. Infec. Des. (IF 8.4) Pub Date : 2024-02-14 Francesco Paolo Bianchi, Donato Rizzi, Antonio Daleno, Pasquale Stefanizzi, Giovanni Migliore, Silvio Tafuri
In 2021, the US Centers for Disease Control and Prevention reported increased cases of myocarditis and pericarditis in the United States after mRNA COVID-19 vaccines. Our study aims to estimate the incidence of myocarditis in Apulia (Southern Italy) and the cause-effect relationship between COVID-19 mRNA vaccines and the risk of myocarditis. The Apulian regional archive of hospital discharge forms