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Remarkable increase in the detection and molecular characterization of adenovirus F41 in children with acute gastroenteritis in Japan, 2017–2023 J. Med. Virol. (IF 12.7) Pub Date : 2024-04-17 Shoko Okitsu, Pattara Khamrin, Toshiyuki Hikita, Yuko Onda, Pham Thi Kim Ngan, Satoshi Hayakawa, Niwat Maneekarn, Hiroshi Ushijima
Human adenovirus (HAdV) is one of the causative viruses of acute gastroenteritis (AGE) in children worldwide. Species F is known to be enteric adenovirus (genotypes 40 and 41) detected in stool samples. In Japan, we conducted an epidemiological study and molecular characterization of HAdV before and after the COVID‐19 pandemic from 2017 to 2023. Among 821 patients, HAdV was detected in 118 AGE cases
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HBV PreC interacts with SUV39H1 to induce viral replication by blocking the proteasomal degradation of viral polymerase J. Med. Virol. (IF 12.7) Pub Date : 2024-04-17 Lidan Hou, Jie Zhao, Liuxin Cai, Ling Jin, Boqiang Liu, Shijie Li, Jin Yang, Tong Ji, Songyi Li, Liang Shi, Bo Shen, Hong Yu, Yifan Wang, Xiujun Cai
Hepatitis B e antigen (HBeAg) seropositivity during the natural history of chronic hepatitis B (CHB) is known to coincide with significant increases in serum and intrahepatic HBV DNA levels. However, the precise underlying mechanism remains unclear. In this study, we found that PreC (HBeAg precursor) genetic ablation leads to reduced viral replication both in vitro and in vivo. Furthermore, PreC impedes
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Poor durability of the neutralizing response against XBB sublineages after a bivalent mRNA COVID-19 booster dose in persons with HIV J. Med. Virol. (IF 12.7) Pub Date : 2024-04-16 Giulia Matusali, Alessandra Vergori, Eleonora Cimini, Davide Mariotti, Valentina Mazzotta, Alessandro Cozzi Lepri, Francesca Colavita, Roberta Gagliardini, Stefania Notari, Silvia Meschi, Marisa Fusto, Eleonora Tartaglia, Enrico Girardi, Fabrizio Maggi, Andrea Antinori
We estimated the dynamics of the neutralizing response against XBB sublineages and T cell response in persons with HIV (PWH) with previous AIDS and/or CD4 < 200/mm3 receiving the bivalent original strain/BA.4-5 booster dose in fall 2022. Samples were collected before the shot (Day 0), 15 days, 3, and 6 months after. PWH were stratified by immunization status: hybrid immunity (HI; vaccination plus COVID-19)
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Incidence of fatigue 2 years after SARS‐CoV‐2 infection: An updated meta‐analysis and subgroup analysis J. Med. Virol. (IF 12.7) Pub Date : 2024-04-16 I‐Wen Chen, Hsiu‐Lan Weng, Yi‐Chen Lai, Kuo‐Chuan Hung
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Naturally developed HPV16 antibodies and risk of newly detected cervical HPV infection outcomes J. Med. Virol. (IF 12.7) Pub Date : 2024-04-16 Andrea Trevisan, João M. G. Candeias, Patrícia Thomann, Luisa L. Villa, Eduardo L. Franco, Helen Trottier
Little is known about the protection conferred by antibodies from natural human papillomavirus (HPV) infection. Our objective was to evaluate the association between HPV16 seroreactivity and HPV16 redetection, newly detected HPV infections, and loss of HPV DNA detection during follow‐up. We analyzed data from 2462 unvaccinated Brazilian women. HPV16 IgG and neutralizing antibodies at baseline were
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Probing molecular pathways: Illuminating the connection between COVID‐19 and Alzheimer's disease through the endocannabinoid system dynamics J. Med. Virol. (IF 12.7) Pub Date : 2024-04-15 Qingyuan Sun, Jinyang Gao, Ran An, Menggeer Wang, Yanqing Wang
Our study investigates the molecular link between COVID‐19 and Alzheimer's disease (AD). We aim to elucidate the mechanisms by which COVID‐19 may influence the onset or progression of AD. Using bioinformatic tools, we analyzed gene expression datasets from the Gene Expression Omnibus (GEO) database, including GSE147507, GSE12685, and GSE26927. Intersection analysis was utilized to identify common differentially
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Convalescent plasma transfusion for immunocompromised viremic patients with COVID‐19: A retrospective multicenter study J. Med. Virol. (IF 12.7) Pub Date : 2024-04-15 Marjolaine Destremau, Hélène Chaussade, Victor Hemar, Mathilde Beguet, Pantxika Bellecave, Elodie Blanchard, Amaury Barret, Gaelle Laboure, Claire Vasco‐Moynet, Flore Lacassin, Eloïse Morisse, Claire Aguilar, Xavier Lafarge, Marie‐Edith Lafon, Fabrice Bonnet, Nahéma Issa, Fabrice Camou
This study aims to assess the safety, virological, and clinical outcomes of convalescent plasma transfusion (CPT) in immunocompromised patients hospitalized for coronavirus disease 2019 (COVID‐19). We conducted a retrospective multicenter cohort study that included all immunosuppressed patients with COVID‐19 and RNAemia from May 2020 to March 2023 treated with CPT. We included 81 patients with hematological
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Impact of a carrageenan gel on viral load of genital human papillomavirus infections in sexually active women: Findings from the Carrageenan‐gel Against Transmission of Cervical Human papillomavirus (CATCH) trial J. Med. Virol. (IF 12.7) Pub Date : 2024-04-12 Cassandra Laurie, Mariam El‐Zein, Joseph E. Tota, Pierre‐Paul Tellier, François Coutlée, Ann N. Burchell, Eduardo L. Franco
Previous research has shown that women's use of a carrageenan gel reduces the risk of acquiring genital human papillomavirus (HPV) infections but does not help to clear existing ones. Although gel use may not result in complete clearance, it may decrease the viral load of HPV infections. We tested this hypothesis in the Carrageenan‐gel Against Transmission of Cervical Human papillomavirus (CATCH) randomized
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Cocirculation and coinfection of multiple respiratory viruses during autumn and winter seasons of 2023 in Beijing, China: A retrospective study J. Med. Virol. (IF 12.7) Pub Date : 2024-04-10 Yi Li, Jinhan Yu, Yao Wang, Jie Yi, Lina Guo, Qing Wang, Ge Zhang, Yingchun Xu, Ying Zhao
China experienced severe epidemics of multiple respiratory pathogens in 2023 after lifting “Zero‐COVID” policy. The present study aims to investigate the changing circulation and infection patterns of respiratory pathogens in 2023. The 160 436 laboratory results of influenza virus and respiratory syncytial virus (RSV) from February 2020 to December 2023, severe acute respiratory syndrome coronavirus
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Metagenomic insights into fungal community composition of the nasopharyngeal region of COVID‐19 associated mucormycosis patients from India J. Med. Virol. (IF 12.7) Pub Date : 2024-04-10 Bharathi Arunan, Daizee Talukdar, Satish Swain, Ashwin Varadarajan, Radhika Sarda, Gagandeep Singh, Neeraj Nischal, Manish Soneja, Susmita Bakshi, Pradipta Jana, Subhash Tanwar, Kapil Sikka, Hitesh Verma, Arulselvi Subramanian, Immaculata Xess, Naveet Wig, Bhabatosh Das, Animesh Ray
Coronavirus disease 2019 (COVID‐19) associated mucormycosis (CAM) was reported predominantly from India during the second wave of COVID‐19 and has a high mortality rate. The present study aims to understand the fungal community composition of the nasopharyngeal region of CAM‐infected individuals and compare it with severe COVID‐19 patients and healthy controls. The fungal community composition was
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Differential beta‐coronavirus infection dynamics in human bronchial epithelial organoids J. Med. Virol. (IF 12.7) Pub Date : 2024-04-09 Dongbin Park, Se‐Mi Kim, Hobin Jang, Kanghee Kim, Ho young Ji, Heedong Yang, Woohyun Kwon, Yeonglim Kang, Suhee Hwang, Hyunjoon Kim, Mark Anthony B. Casel, Issac Choi, Jeong‐Sun Yang, Joo‐Yeon Lee, Young Ki Choi
The lower respiratory system serves as the target and barrier for beta‐coronavirus (beta‐CoV) infections. In this study, we explored beta‐CoV infection dynamics in human bronchial epithelial (HBE) organoids, focusing on HCoV‐OC43, SARS‐CoV, MERS‐CoV, and SARS‐CoV‐2. Utilizing advanced organoid culture techniques, we observed robust replication for all beta‐CoVs, particularly noting that SARS‐CoV‐2
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Prevalence and genetic diversity of human rhinovirus among patients with acute respiratory infections in China, 2012−2021 J. Med. Virol. (IF 12.7) Pub Date : 2024-04-09 Aili Cui, Baicheng Xia, Haoran Jiang, Qi Li, Liwei Sun, Jin Xu, Kongxin Hu, Zhibo Xie, Yage Wang, Runan Zhu, Chaoyang Huang, Zhong Li, Jing Xu, Wenyang Wang, Hui Zhang, Zhenguo Gao, Feng Zhang, Hui Xie, Yan Zhang
To understand the prevalence of rhinovirus (RV) among acute respiratory infection (ARI) patients, 10‐year ARI surveillance in multiple provinces of China were conducted during 2012−2021. Of 15 645 ARI patients, 1180 (7.54%) were confirmed to have RV infection and 820 (69.49%) were children under 5 years of age. RV typing was performed on the 527 VP1 gene sequences, and species A, B, and C accounted
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Targeted therapies for HPV‐associated cervical cancer: Harnessing the potential of exosome‐based chipsets in combating leukemia and HPV‐mediated cervical cancer J. Med. Virol. (IF 12.7) Pub Date : 2024-04-09 Swastika Maitra, Nobendu Mukerjee, Hanan M. Alharbi, Arabinda Ghosh, Athanasios Alexiou, Nanasaheb D. Thorat
Exosomes play a crucial role in intercellular communication and have emerged as significant vehicles for transporting disease‐specific biomarkers. This feature provides profound insights into the progression of diseases and the responses of patients to treatments. For example, in leukemia, exosomes convey critical information through the carriage of specific proteins and nucleic acids. In the case
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The abortive SARS‐CoV‐2 infection of osteoclast precursors promotes their differentiation into osteoclasts J. Med. Virol. (IF 12.7) Pub Date : 2024-04-08 Franco Sviercz, Patricio Jarmoluk, Joshua Godoy Coto, Cintia Cevallos, Rosa Nicole Freiberger, Cinthya Alicia Marcela López, Irene Lucia Ennis, M. Victoria Delpino, Jorge Quarleri
The Coronavirus Disease 2019 (COVID‐19) pandemic has resulted in the loss of millions of lives, although a majority of those infected have managed to survive. Consequently, a set of outcomes, identified as long COVID, is now emerging. While the primary target of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the respiratory system, the impact of COVID‐19 extends to various body parts
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Obesity fosters severe disease outcomes in a mouse model of coronavirus infection associated with transcriptomic abnormalities J. Med. Virol. (IF 12.7) Pub Date : 2024-04-08 Pallavi Rai, Jeffrey M. Marano, Lin Kang, Sheryl Coutermarsh‐Ott, Andrea R. Daamen, Peter E. Lipsky, James Weger‐Lucarelli
Obesity has been identified as an independent risk factor for severe outcomes in humans with coronavirus disease 2019 (COVID‐19) and other infectious diseases. Here, we established a mouse model of COVID‐19 using the murine betacoronavirus, mouse hepatitis virus 1 (MHV‐1). C57BL/6 and C3H/HeJ mice exposed to MHV‐1 developed mild and severe disease, respectively. Obese C57BL/6 mice developed clinical
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Evaluation of serum Epstein–Barr virus envelope glycoproteins antibodies and their association with systemic autoimmune diseases J. Med. Virol. (IF 12.7) Pub Date : 2024-04-08 Hui‐Lan Li, Lan‐Yi Zhong, Yin‐Feng Kang, Yan‐Lan Yang, Liang Shi, Ai‐Xia Zhai, Chao Wu, Mu‐Sheng Zeng, Qian‐Ying Zhu
Systemic autoimmune diseases (SADs) are a growing spectrum of autoimmune disorders that commonly affect multiple organs. The role of Epstein–Barr virus (EBV) infection or reactivation as a trigger for the initiation and progression of SADs has been established, while the relationship between EBV envelope glycoproteins and SADs remains unclear. Here, we assessed the levels of IgG, IgA, and IgM against
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Survival benefits of human papillomavirus 16 infection in patients with esophageal squamous cell carcinoma undergoing chemoradiotherapy: A retrospective cohort study J. Med. Virol. (IF 12.7) Pub Date : 2024-04-08 Fengyi Qu, Chao Ji, Ying Wang, Rui Zhu, Weibin Hu, Siqi Liu, Xu Zhao, Jing Li, Guo Miao, Mingxin Zhang, Xiaozhi Zhang, Yuchen Sun
The role of human papillomavirus 16 (HPV 16) in esophageal squamous cell carcinoma (ESCC) remains uncertain. Therefore, this study aimed to investigate the prevalence of HPV 16 in patients with ESCC and its impact on theirprognosis. HPV 16 was detected using FISH, and TP53 status was evaluated via immunohistochemistry. The factors influencing prognosis were ananalyzed using the Log‐rank test and Cox
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Triglicerydes/high‐density lipoprotein ratio as a risk factor of post‐Covid‐19 sinus tachycardia: A retrospective study J. Med. Virol. (IF 12.7) Pub Date : 2024-04-08 Alina Kuryłowicz, Mateusz Babicki, Michał Wąsowski, Piotr Jankowski, Joanna Kapusta, Michał Chudzik
Inappropriate sinus tachycardia (IST) is one of the manifestations of the post‐COVID‐19 syndrome (PCS), which pathogenesis remains largely unknown. This study aimed to identify potential risk factors for IST in individuals with PCS. The 1349 patients with PCS were included into the study. Clinical examination, 24H Holter ECG, 24H ambulatory blood pressure monitoring and biochemical tests were performed
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A peptide derived from SARS‐CoV‐2 nucleocapsid protein with broad‐spectrum anti‐coronavirus activity J. Med. Virol. (IF 12.7) Pub Date : 2024-04-08 Guoguo Ye, Yimin Tang, Qin Yang, Chenhui Zhang, Huiping Shi, Jun Wang, Xiao Hu, Xiaofu Wan, Zhixiang Xu, Jinhu Liang, Yang Yang, Minghui Yang, Yingxia Liu
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TLR4 TIR domain and nucleolin GAR domain synergistically mediate RSV infection and induce neuronal inflammatory damage in SH-SY5Y cells J. Med. Virol. (IF 12.7) Pub Date : 2024-04-01 Chengcheng Jiang, Yixuan Huang, Hongya Gui, Xiaojie Liu, Haiwen Li, Maozhen Han, Shenghai Huang
Previous research results of our group showed that Toll-like receptor 4 (TLR4) and nucleolin synergistically mediate respiratory syncytial virus (RSV) infection in human central neuron cells, but the specific mechanism remains unclear. Here we designed and synthesized lentiviruses with TIR (674–815 aa), TLR4 (del 674–815 aa), GAR (645–707 aa), and NCL (del 645–707 aa) domains, and obtained stable overexpression
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Discovery of low‐molecular‐weight phenylalanine derivatives as novel HIV capsid modulators with improved antiretroviral activity and metabolic stability J. Med. Virol. (IF 12.7) Pub Date : 2024-04-05 Xiangyi Jiang, Zhen Gao, Prem Prakash Sharma, Sumit Kumar, Brijesh Rathi, Xiangkai Ji, Jiaojiao Dai, Minghui Xie, Guanyu Dong, Shujing Xu, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Peng Zhan, Xinyong Liu
The HIV capsid (CA) protein is a promising target for anti‐AIDS treatment due to its critical involvement in viral replication. Herein, we utilized the well‐documented CA inhibitor PF74 as our lead compound and designed a series of low‐molecular‐weight phenylalanine derivatives. Among them, compound 7t exhibited remarkable antiviral activity with a high selection index (EC50 = 0.040 µM, SI = 2815)
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Measles outbreak in the adult age group: Clinical, laboratory, and epidemiological features of the 11 patients admitted to the hospital J. Med. Virol. (IF 12.7) Pub Date : 2024-04-05 Kultural Gungor, Sebnem Bukavaz, Galip Ekuklu
The measles virus, also known as the morbillivirus, or MV, is a virus that infects humans. The goal of this research is to assess to adult cases of measles. Eleven patients thought to be confirmed cases of measles were enrolled in the investigation. Following the identification of symptoms of tiredness, fever, and rash in one soldier, the results of 10 more troops from the pertinent military group
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Comparative single‐cell RNA sequencing analysis of immune response to inactivated vaccine and natural SARS‐CoV‐2 infection J. Med. Virol. (IF 12.7) Pub Date : 2024-04-04 Shuai He, Shu‐Qiang Liu, Xiang‐Yun Teng, Jin‐Yong He, Yang Liu, Jia‐Hui Gao, Yue Wu, Wei Hu, Zhong‐Jun Dong, Jin‐Xin Bei, Jian‐Hua Xu
Uncovering the immune response to an inactivated SARS‐CoV‐2 vaccine (In‐Vac) and natural infection is crucial for comprehending COVID‐19 immunology. Here we conducted an integrated analysis of single‐cell RNA sequencing (scRNA‐seq) data from serial peripheral blood mononuclear cell (PBMC) samples derived from 12 individuals receiving In‐Vac compared with those from COVID‐19 patients. Our study reveals
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TRPV4 promotes HBV replication and capsid assembly via methylation modification of H3K4 and HBc ubiquitin J. Med. Virol. (IF 12.7) Pub Date : 2024-04-04 Yu Zhang, Xiaoxue Yuan, Jun Wang, Ming Han, Hongping Lu, Yun Wang, Shunai Liu, Song Yang, Hui‐Chun Xing, Jun Cheng
Hepatitis B virus (HBV) infection poses a significant burden on global public health. Unfortunately, current treatments cannot fully alleviate this burden as they have limited effect on the transcriptional activity of the tenacious covalently closed circular DNA (cccDNA) responsible for viral persistence. Consequently, the HBV life cycle should be further investigated to develop new anti‐HBV pharmaceutical
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The use of human iPSC‐derived alveolar organoids to explore SARS‐CoV‐2 variant infections and host responses J. Med. Virol. (IF 12.7) Pub Date : 2024-04-04 Chaitanya Gandikota, Kishore Vaddadi, Pulavendran Sivasami, Chaoqun Huang, Yurong Liang, Samuel Pushparaj, Xufang Deng, Rudragouda Channappanava, Jordan P. Metcalf, Lin Liu
Severe acute respiratory syndrome‐related coronavirus 2 (SARS‐CoV‐2) primarily targets the respiratory system. Physiologically relevant human lung models are indispensable to investigate virus‐induced host response and disease pathogenesis. In this study, we generated human induced pluripotent stem cell (iPSC)‐derived alveolar organoids (AOs) using an established protocol that recapitulates the sequential
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Retraction: “Small Interfering RNA Effectively Inhibits Protein Expression and Negative Strand RNA Synthesis From a Full‐Length Hepatitis C Virus Clone” J. Med. Virol. (IF 12.7) Pub Date : 2024-04-04
Retraction: “Small Interfering RNA Effectively Inhibits Protein Expression and Negative Strand RNA Synthesis From a Full‐Length Hepatitis C Virus Clone” by Prabhu, R., Vittal, P., Yin, Q., Flemington, E., Garry, R., Robichaux, W.H. and Dash, S, J. Med. Virol 2005, 76: 511‐519. The above article, published online on 23 June 2005, in Wiley Online Library (https://doi.org/10.1002/jmv.20391), has been
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Global burden of vaccine‐associated multiple sclerosis, 1967–2022: A comprehensive analysis of the international pharmacovigilance database J. Med. Virol. (IF 12.7) Pub Date : 2024-04-04 Ho Geol Woo, Hyeon Jin Kim, Jaeyu Park, Jinseok Lee, Hayeon Lee, Min Seo Kim, Ai Koyanagi, Lee Smith, Masoud Rahmati, Seung Geun Yeo, Dong Keon Yon
Vaccine‐associated multiple sclerosis (MS) is rare, with insufficient evidence from case reports. Given the scarcity of large‐scale data investigating the association between vaccine administration and adverse events, we investigated the global burden of vaccine‐associated MS and potential related vaccines from 1967 to 2022. Reports on vaccine‐associated MS between 1967 and 2022 were obtained from
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Two‐ and 3‐year outcomes in convalescent individuals with COVID‐19: A prospective cohort study J. Med. Virol. (IF 12.7) Pub Date : 2024-04-04 Huqin Yang, Lujia Guan, Tingyu Yang, Haomiao Ma, Xuefeng Liu, Xuyan Li, Jieqiong Li, Zhaohui Tong
As the long‐term consequences of coronavirus disease 2019 (COVID‐19) have not been defined, it is necessary to explore persistent symptoms, long‐term respiratory impairment, and impact on quality of life over time in COVID‐19 survivors. In this prospective cohort study, convalescent individuals diagnosed with COVID‐19 were followed‐up 2 and 3 years after discharge from hospital. Participants completed
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Measles disease outbreaks and vaccination impacting global public health J. Med. Virol. (IF 12.7) Pub Date : 2024-04-04 Hinh Ly
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Persistence of IgG and neutralizing antibodies in Crimean−Congo hemorrhagic fever survivors J. Med. Virol. (IF 12.7) Pub Date : 2024-04-04 Abbas Ahmadi Vasmehjani, Mohammad Hassan Pouriayevali, Shohreh Shahmahmoodi, Mostafa Salehi‐Vaziri
The World Health Organization classified Crimean–Congo hemorrhagic fever (CCHF) as a high‐priority infectious disease and emphasized the performance of research studies and product development against it. Little information is available about the immune response due to natural CCHF virus (CCHFV) infection in humans. Here, we investigated the persistence of IgG and neutralizing antibodies in serum samples
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Immune features revealed by single‐cell RNA and single‐cell TCR/BCR sequencing in patients with rheumatoid arthritis receiving COVID‐19 booster vaccination J. Med. Virol. (IF 12.7) Pub Date : 2024-04-03 Yong Fan, Siyuan Huang, Duo Wu, Ming Chu, Juan Zhao, Jiaying Zhang, Yu Wang, Yanni Gui, Xiaofei Ye, Guiqiang Wang, Yan Geng, Yuedan Wang, Zhuoli Zhang
Coronavirus disease 2019 (COVID‐19), caused by SARS‐CoV‐2, have profoundly affected human health. Booster COVID‐19 vaccines have demonstrated significant efficacy in reducing infection and severe cases. However, the effects of booster COVID‐19 vaccines on key immune cell subsets and their responses in rheumatoid arthritis (RA) are not well understood. By using single‐cell RNA sequencing (scRNA‐seq)
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miR‐129‐5p inhibits anchorage‐independent growth through silencing of ACTN1 and the ELK4/c‐FOS axis in HPV‐transformed keratinocytes J. Med. Virol. (IF 12.7) Pub Date : 2024-04-03 Angelina Huseinovic, Mengfei Xu, Annelieke Jaspers, Brigitte Bais, Renske D. M. Steenbergen
A persistent infection with human papillomavirus (HPV) can induce precancerous lesions of the cervix that may ultimately develop into cancer. Cervical cancer development has been linked to altered microRNA (miRNA) expression, with miRNAs regulating anchorage‐independent growth being particularly important for the progression of precancerous lesions to cancer. In this study, we set out to identify and
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Long‐term dynamics of natural killer cells in response to SARS‐CoV‐2 vaccination: Persistently enhanced activity postvaccination J. Med. Virol. (IF 12.7) Pub Date : 2024-04-03 Dalila Mele, Sabrina Ottolini, Andrea Lombardi, Daniela Conteianni, Alessandra Bandera, Barbara Oliviero, Stefania Mantovani, Irene Cassaniti, Fausto Baldanti, Andrea Gori, Mario U. Mondelli, Stefania Varchetta
Natural Killer (NK) cells play a significant role in the early defense against virus infections and cancer. Recent studies have demonstrated the involvement of NK cells in both the induction and effector phases of vaccine‐induced immunity in various contexts. However, their role in shaping immune responses following SARS‐CoV‐2 vaccination remains poorly understood. To address this matter, we conducted
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An updated meta‐analysis of pooled incidence of remdesivir‐associated bradycardia J. Med. Virol. (IF 12.7) Pub Date : 2024-04-02 Kuo‐Chuan Hung, Wei‐Ting Wang, I‐Yin Hung, I‐Wen Chen
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Maternal human papillomavirus infection and the risk of congenital malformations: A nationwide population‐based cohort study J. Med. Virol. (IF 12.7) Pub Date : 2024-04-02 Tina Yi Jin Hsieh, Thomas Yen Ting Chen, Pei‐Lun Liao, Jing‐Yang Huang, Kevin Sheng‐Kai Ma, Yao‐Min Hung, Renin Chang, James Cheng‐Chung Wei
Previous research has explored theories regarding the vertical transmission of human papillomavirus (HPV) infection and its association with adverse pregnancy and perinatal outcomes. However, the impact of maternal HPV infection on congenital anomalies (CAs) in offspring remains relatively understudied. We conducted a population‐based cohort study linking the Taiwan Birth Registry, Taiwan Death Registry
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Modulation of lung regenerative therapy by micro‐RNA in viral pneumonia J. Med. Virol. (IF 12.7) Pub Date : 2024-04-02 Chen Huang
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Laurencia johnstonii extract reverses early lesions in the K14E7HPV16 murine cervical carcinogenesis model J. Med. Virol. (IF 12.7) Pub Date : 2024-04-02 Erandi Arvizu‐Hernandez, Claudia Judith Hernandez‐Guerrero, Elizabeth Alvarez‐Rios, Patricio Gariglio, Jorge Cornejo‐Garrido, Rodolfo Ocadiz‐Delgado
Persistent infection with high‐risk human papillomavirus (HR‐HPV) is a well‐established risk factor to the development of cervical intraepithelial neoplasia (CIN), a condition that can progress to cervical cancer (CC) a major health problem worldwide. Recently, there has been growing interest in exploring alternative therapies utilizing natural products, among which is the algae species Laurencia johnstonii
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Influenza vaccination on SARS‐CoV‐2 infection risk: A subgroup analysis on geographic factor J. Med. Virol. (IF 12.7) Pub Date : 2024-04-01 Kuo‐Chuan Hung, Ting‐Sian Yu, Kuei‐Fen Wang, I‐Wen Chen
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Human transmission and outbreaks of feline‐like G6 rotavirus revealed with whole‐genome analysis of G6P[9] feline rotavirus J. Med. Virol. (IF 12.7) Pub Date : 2024-04-01 Yuya Fukuda, Hajime Kusuhara, Reiko Takai‐Todaka, Kei Haga, Kazuhiko Katayama, Takeshi Tsugawa
Group A rotaviruses (RVAs) are generally highly species‐specific; however, some strains infect across species. Feline RVAs sporadically infect humans, causing gastroenteritis. In 2012 and 2013, rectal swab samples were collected from 61 asymptomatic shelter cats at a public health center in Mie Prefecture, Japan, to investigate the presence of RVA and any association with human infections. The analysis
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Association of HBV serological markers with host antiviral immune response relevant hepatic inflammatory damage in chronic HBV infection J. Med. Virol. (IF 12.7) Pub Date : 2024-03-29 Bei Jiang, Leijie Wang, Huan Liu, Lin Wang, Rui Su, Liang Xu, Guochao Wei, Jia Li, Fengmin Lu, Xiangmei Chen
The natural progression of chronic hepatitis B virus (HBV) infection is dynamic, but the longitudinal landscape of HBV serological markers with host antiviral immune response relevant hepatic inflammatory damage remains undetermined. To this issue, we studied the association of HBV serological markers with the severity of hepatic inflammatory damage and enumerated HBV‐specific T cells using the cultured
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Prevalence, tropism, and activity of cutavirus in circulating blood lymphocytes, stool, and skin biopsy specimens of patients with cutaneous T‐cell lymphoma and parapsoriasis en plaques J. Med. Virol. (IF 12.7) Pub Date : 2024-03-29 Ushanandini Mohanraj, Liisa Väkevä, Annamari Ranki, Maria Söderlund‐Venermo
A significant association has been established between a newly emerging human parvovirus, cutavirus (CuV), and cutaneous T‐cell lymphoma/mycosis fungoides (CTCL/MF) and its precursor parapsoriasis en plaques (PP). CTCL is a heterogeneous group of skin malignancies of T cells, the cause of which remains unknown. This study aimed to determine the activity, spread, and cell tropism of the skin‐persistent
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Swine pseudorabies virus attenuated vaccine reprograms the kidney cancer tumor microenvironment and synergizes with PD-1 blockade J. Med. Virol. (IF 12.7) Pub Date : 2024-03-28 Mengxuan Gui, Chongxin Wu, Ruoyao Qi, Yue Zeng, Pengfei Huang, Jiali Cao, Tian Chen, Kaiyun Chen, Lina Lin, Qiangyuan Han, Peiqing He, Rao Fu, Qian Wu, Quan Yuan, Tianying Zhang, Ningshao Xia, Guosong Wang, Yixin Chen
The global incidence rate of kidney cancer (KC) has been steadily increasing over the past 30 years. With the aging global population, kidney cancer has become an escalating concern that necessitates vigilant surveillance. Nowadays, surgical intervention remains the optimal therapeutic approach for kidney cancer, while the availability of efficacious treatments for advanced tumors remains limited.
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Hesperetin blocks poxvirus replication with a low tendency to select for drug‐resistant viral variants J. Med. Virol. (IF 12.7) Pub Date : 2024-03-28 Assim Verma, Ramesh Kumar Dedar, Ram Kumar, Yogesh Chander, Himanshu Kamboj, Garvit Kumar, Rekha Verma, Santosh Kumari, Shalini Sharma, Bhupendra N. Tripathi, Sanjay Barua, Naveen Kumar
In this study, we demonstrated the antiviral efficacy of hesperetin against multiple poxviruses, including buffalopox virus (BPXV), vaccinia virus (VACV), and lumpy skin disease virus (LSDV). The time‐of‐addition and virus step‐specific assays indicated that hesperetin reduces the levels of viral DNA, mRNA, and proteins in the target cells. Further, by immunoprecipitation (IP) of the viral RNA from
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Identification of a novel orthonairovirus from ticks and serological survey in animals near China–North korea border J. Med. Virol. (IF 12.7) Pub Date : 2024-03-28 Fan Li, Jixu Li, Jingdong Song, De Li, Qikai Yin, Shihong Fu, Kai Nie, Qianqian Cui, Songtao Xu, Qiang Wei, Huanyu Wang
Emerging pathogenic tick‐borne viruses (TBVs) have attracted a great deal of attention due to their significant impact on human and animal health. A novel orthonairovirus named Dadong virus (DDV) was isolated from Haemaphysalis concinna ticks in the Changbai Mountain region on the China–North Korea border. DDV can induce cytopathic effects in mammalian and human cell lines. Phylogenetic analysis showed
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Cover Image, Volume 96, Number 3, March 2024 J. Med. Virol. (IF 12.7) Pub Date : 2024-03-27 Minji Lee, Chi‐Hwan Choi, Jin‐Won Kim, Gyuri Sim, Sang Eun Lee, Hwachul Shin, Jeong hyun Lee, Myung‐Min Choi, Hwajung Yi, Yoon‐Seok Chung
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Langat virus inhibits the gp130/JAK/STAT signaling by reducing the gp130 protein level J. Med. Virol. (IF 12.7) Pub Date : 2024-03-27 Shaoli Lin, Xiaochun Wang, Bhargava Teja Sallapalli, Adam Hage, Peixi Chang, Jia He, Sonja M. Best, Yanjin Zhang
The tick‐borne encephalitis virus (TBEV) serocomplex includes several medically important flavivirus members endemic to Europe, Asia, and North America, which can induce severe neuroinvasive or viscerotropic diseases with unclear mechanisms of pathogenesis. Langat virus (LGTV) shares a high sequence identity with TBEV but exhibits lower pathogenic potential in humans and serves as a model for virus‐host
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Langat virus, a prototypic tick‐borne encephalitis virus, impacts IL‐6 signaling by downregulating gp130 expression J. Med. Virol. (IF 12.7) Pub Date : 2024-03-27 Morgan Brisse, Hinh Ly
Tick-borne flaviviruses make up a distinct and substantial arm of the Flaviviridae family, currently consisting of 12 members of which eight can cause human disease.1-3 Five members (tick-borne encephalitis virus [TBEV], louping ill virus [LIV], Kyasanur Forest diseases virus [KFDV], Powassan virus [POWW] and Omsk hemorrhagic fever virus [OHFV]) comprise the human “tick-borne encephalitis (TBE) serocomplex
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Effective vaccination strategies for human papillomavirus (HPV) infection and cervical cancer based on the mathematical model with a stochastic process J. Med. Virol. (IF 12.7) Pub Date : 2024-03-27 Minsoo Kim, Eunjung Kim
Human papillomavirus (HPV) infection poses a significant risk to women's health by causing cervical cancer. In addition to HPV, cervical cancer incidence rates can be influenced by various factors, including human immunodeficiency virus and herpes, as well as screening policy. In this study, a mathematical model with stochastic processes was developed to analyze HPV transmission between genders and
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Estimated cytomegalovirus seroprevalence in the general population of the United States and Canada J. Med. Virol. (IF 12.7) Pub Date : 2024-03-26 W. Dana Flanders, Cathy Lally, Anne Dilley, John Diaz‐Decaro
Seroprevalence data for cytomegalovirus (CMV), a widespread virus causing lifelong infection, vary widely, and contemporary data from the United States (US) and Canada are limited. Utilizing a modeling approach based on a literature review (conducted August, 2022) of data published since 2005, we determine age‐, sex‐, and country‐specific CMV seroprevalence in the general US and Canadian populations
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Juveniles, young adults, and infants with hepatitis B virus infection: A genomic study J. Med. Virol. (IF 12.7) Pub Date : 2024-03-26 Hanwen Zhang, Meina Li, Huijuan Liu, Yi Dong, Weijie Li, Pan Zhao
Integration of hepatitis B virus (HBV) DNA into the human genome is recognized as an oncogenic factor and a barrier to hepatitis B cure. In the study, biopsy liver tissues were collected from adolescents and young adults with acute HBV infection younger than or equal to 35 years of age and from HBV‐infected infant patients younger than or equal to 6 months of age. A high‐throughput sequencing method
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The antiviral potential of the antiandrogen enzalutamide and the viral‐androgen signaling interplay in seasonal coronaviruses J. Med. Virol. (IF 12.7) Pub Date : 2024-03-26 Oluwadamilola D. Ogunjinmi, Tukur Abdullahi, Riaz‐Ali Somji, Charlotte L. Bevan, Wendy S. Barclay, Nigel Temperton, Greg N. Brooke, Efstathios S. Giotis
The sex disparity in COVID‐19 outcomes with males generally faring worse than females has been associated with the androgen‐regulated expression of the protease TMPRSS2 and the cell receptor ACE2 in the lung and fueled interest in antiandrogens as potential antivirals. In this study, we explored enzalutamide, an antiandrogen used commonly to treat prostate cancer, as a potential antiviral against the
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Cover Image, Volume 96, Number 2, February 2024 J. Med. Virol. (IF 12.7) Pub Date : 2024-03-26 Milena Silva Souza, Jéssica Pires Farias, Robert Andreata‐Santos, Marianne Pereira Silva, Ruth Dálety da Silva Brito, Marcia Duarte Barbosa da Silva, Cristina Mendes Peter, Marcus Vinícius de França Cirilo, Wilson Barros Luiz, Alexander Birbrair, Paloma Oliveira Vidal, Maria Fernanda de Castro‐Amarante, Erika Donizetti Candido, Aldilene Silva Munhoz, Fernanda de Mello Malta, Erik Gustavo Dorlass, Rafael
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Use of a carrageenan‐based gel had no impact on anal HPVs 16 and 18 viral loads in gay, bisexual, and other men who have sex with men J. Med. Virol. (IF 12.7) Pub Date : 2024-03-26 Pareesa Kassam, Mariam El‐Zein, Cassandra Laurie, Joseph E. Tota, Pierre‐Paul Tellier, François Coutlée, Alexandra de Pokomandy, Eduardo L. Franco
The Lubricant Investigation in Men to Inhibit Transmission of human papillomavirus (HPV) Infection randomized control trial in gay, bisexual, and other men who have sex with men (gbMSM) found that carrageenan use neither reduced acquisition of anal HPV infections nor influenced infection clearance. To investigate carrageenan's lack of protective effect, we compared the change in anal HPV16 and HPV18
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Neutralizing antibody response to SARS‐CoV‐2 bivalent mRNA vaccine in SIV‐infected rhesus macaques: Enhanced immunity to XBB subvariants by two‐dose vaccination J. Med. Virol. (IF 12.7) Pub Date : 2024-03-26 Julia N. Faraone, Xiaolwei Wang, Panke Qu, Yi‐Min Zheng, Eunice Vincent, Huanbin Xu, Shan‐Lu Liu
The evolution of SARS‐CoV‐2 paired with immune imprinting by prototype messenger RNA (mRNA) vaccine has challenged the current vaccination efficacy against newly emerged Omicron subvariants. In our study, we investigated a cohort of macaques infected by SIV and vaccinated with two doses of bivalent Pfizer mRNA vaccine containing wildtype and BA.5 spikes. Using a pseudotyped lentivirus neutralization
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Evaluation of the effectiveness and safety of sequential vaccination with inactivated SARS‐CoV‐2 vaccine and Ad5‐nCoV booster in pediatric liver transplant recipients J. Med. Virol. (IF 12.7) Pub Date : 2024-03-26 Zhigang Zheng, Huimin Wu, Xiaowei Sun, Yefeng Lu, Yanyan Song, Yi Luo, Tao Zhou, Mingxuan Feng, Ping Wan, Jianjun Zhu, Nan Shen, Qing Cao, Ji Liang, Qiang Xia, Feng Xue
Amidst the COVID‐19 pandemic, uncertainty persists among caregivers regarding the vaccination of pediatric liver transplant recipients (PLTRs). This study evaluates the immunogenicity and safety of COVID‐19 vaccination in this vulnerable population. A cohort of 30 PLTRs underwent sequential vaccinations with an inactivated SARS‐CoV‐2 vaccine followed by an Ad5‐nCoV booster. We collected and analyzed
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Novel diarylpyrimidine subtypes as HIV‐1 nonnucleoside reverse transcriptase inhibitors with improved resistance profile J. Med. Virol. (IF 12.7) Pub Date : 2024-03-22 Zhengqiang Wang
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High pre‐Delta and early‐Omicron SARS‐CoV‐2 seroprevalence detected in dried blood samples from Kinshasa (D.R. Congo) J. Med. Virol. (IF 12.7) Pub Date : 2024-03-22 Paula Martínez de Aguirre, Silvia Carlos, Manuel Pina‐Sánchez, Samclide Mbikayi, Eduardo Burgueño, Céline Tendobi, Luis Chiva, África Holguín, Gabriel Reina
Studies on the impact of the COVID‐19 pandemic in sub‐Saharan Africa have yielded varying results, although authors universally agree the real burden surpasses reported cases. The primary objective of this study was to determine SARS‐CoV‐2 seroprevalence among patients attending Monkole Hospital in Kinshasa (D.R. Congo). The secondary objective was to evaluate the analytic performance of two chemiluminescence
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TRIM6 facilitates SARS‐CoV‐2 proliferation by catalyzing the K29‐typed ubiquitination of NP to enhance the ability to bind viral genomes J. Med. Virol. (IF 12.7) Pub Date : 2024-03-22 Jian Zhou, Yuzheng Zhou, Xia‐Fei Wei, Lujie Fan, Xiang Gao, Yunfei Li, Yezi Wu, Wei Feng, XiaoTong Shen, Lei Liu, Gang Xu, Zheng Zhang
The Nucleocapsid Protein (NP) of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is not only the core structural protein required for viral packaging, but also participates in the regulation of viral replication, and its post‐translational modifications such as phosphorylation have been shown to be an important strategy for regulating virus proliferation. Our previous work identified NP
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Association between monoclonal antibody therapy, vaccination, and longer‐term symptom resolution after acute COVID‐19 J. Med. Virol. (IF 12.7) Pub Date : 2024-03-22 Samantha C. Roberts, Sarah E. Jolley, Laurel E. Beaty, Neil R. Aggarwal, Tellen D. Bennett, Nichole E. Carlson, Lindsey E. Fish, Bethany M. Kwan, Seth Russell, Adane F. Wogu, Matthew A. Wynia, Adit A. Ginde
Effective therapies for reducing post‐acute sequelae of COVID‐19 (PASC) symptoms are lacking. Evaluate the association between monoclonal antibody (mAb) treatment or COVID‐19 vaccination with symptom recovery in COVID‐19 participants. The longitudinal survey‐based cohort study was conducted from April 2021 to January 2022 across a multihospital Colorado health system. Adults ≥18 years with a positive