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Corrigendum to “The fexA gene in Campylobacter: whether the spread has occurred among various hosts in eastern China” [Journal of Global Antimicrobial Resistance 36 (2024) 293-300] J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-03-13 Pingyu Huang, Chong Chen, Xiaoqi Zang, Qinyue Jiang, Yilin Lv, Hongyue Lv, Yanying Qin, Xinan Jiao, Jinlin Huang
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Corrigendum to “Letter in response to first case of persistent Stenotrophomonas maltophilia bacteremia due to septic thrombosis successfully treated with a Cefiderocol-containing regimen” [Journal of Global Antimicrobial Resistance 36 (2024) 307-308] J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-03-12 Gayatree Nayak, Sushree Sarathi, Bijayini Behera, Ashoka Mahapatra, Jayanti Jena, Srujana Mohanty
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Changes in antimicrobial resistance of Escherichia coli isolated from community associated urinary tract infection before and during the COVID-19 pandemic in India J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-03-07 Shwetha Venugopal, Sneha Chunchanur, Rajashree Panigrahy, Vibhor Tak, Manish Yadav, Akanksha Chauhan, Himabindhu KS, Jayapriya R, Swati Pundir, Satyendra Bhatt, Birasen Behera, Sumanth M, Ambica R, Susmita Chaudhuri, Sarita Mohapatra, Investigators of CAUTION-ED STUDY(Community-acquired UTI & Emerging Drug Resistance)
Impact of COVID-19 pandemic on antimicrobial resistance (AMR) is largely studied in healthcare settings, there is a need to understand the fluctuations in AMR during pandemic at the community level. Urinary tract infection (UTI) being one of the most common infections in the community, AMR profile of Community-acquired UTI (CA-UTI) is considered representative AMR at the community level. The study
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Genomic characterization of blaNDM-5-IncX3 plasmid in a ST4 Klebsiella aerogenes clinical isolate J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-03-07 Fen Pan, Qi Xu, Cong Jiang, Qingqing Du, Fangyuan Yu, Pengcheng Chen, Hong Zhang
The dissemination of New Delhi metallo-β-lactamase-5 (NDM-5) among various species of has attracted serious global attention. Here, we characterized the genomic characterization of blaNDM-5-IncX3 plasmid (pNDM-KA3) in a ST4 Klebsiella aerogenes (KA3) strain isolated from a neonate with pneumonia. Antimicrobial susceptibility and multilocus sequence typing were performed for the KA3. Plasmid conjugation
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The features of multidrug-resistant organisms between 2016 and March 2023 and its change after the end of Zero-COVID-19 policy in a teaching hospital in Shenzhen, China J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-03-06 Hongwei Shen, Danli Xiao, Qiaomin Zhang, Shaobo Li, Haihong He, Xiaoyan Dai, Hanlian Huang, Wen Ma
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Pseudomonas aeruginosa strains isolated from animal with high virulence genes content and highly sensitive to antimicrobials. J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-03-06 Rosario Morales-Espinosa, Gabriela Delgado, Fernando Espinosa-Camacho, Alejandro Flores-Alanis, Cristina Rodriguez, Jose L Mendez, Alejandro Cravioto
is one of the most metabolically versatile bacteria having the ability to survive in multiple environments through its accessory genome. An important hallmark of is the high level of antibiotic resistance, which often makes eradication difficult and sometimes impossible. Evolutionary forces have led to this high microbial resistance with a variety of elements contributing to both intrinsic and acquired
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Corrigendum to “Therapeutic drug monitoring of imipenem/cilastatin and meropenem in critically ill adult patients” [Journal of Global Antimicrobial Resistance 36 (2024) 252-259] J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-03-02 Xi You, Qing Dai, Jing Hu, Mingjie Yu, Xiaowen Wang, Bangbi Weng, Lin Cheng, Fengjun Sun
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Genetic characterization of KHM-1 metallo-β-lactamase-producing Enterobacterales isolates from inpatient sources in Osaka, Japan J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-29 Kaoru Umeda, Masaki Anraku, Takahiro Yamaguchi, Hiromi Nakamura, Ryuji Kawahara
KHM-1-metallo-β-lactamase-producing strains, of which only a few have been found, were isolated from four inpatients in Osaka, Japan during 2016–2020. We compared whole genomes of the four KHM-1-producing isolates, including one subsp. , one , and two . These isolates were characterized by whole-genome sequencing, comparative analysis of -encoding plasmids with earlier reported plasmids, and antimicrobial
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Report of Salmonella Saintpaul from chicken carcass co-harbouring blaCTX-M2 and mcr-9.1 J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-27 Arthur de Almeida Figueira, Thomas Salles Dias, Gisllany Alves Costa, Giovanna Silva de Souza, Dayse Lima da Costa Abreu, Luciana dos Santos Medeiros, Virginia Léo de Almeida Pereira
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Characterisation of an IncX4 plasmid harbouring mcr-1 from Escherichia fergusonii from chicken meat in China J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-25 Cai-Yue Mei, Xing-Xing Zhang, Yue Jiang, Qin-Chun Ma, Zhen-Yu Wang, Xinan Jiao, Fa-Gang Zhong, Jing Wang
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Clinical characteristics and risk factors for neonatal bloodstream infection due to carbapenem-resistant Enterobacteriaceae: A single-centre Chinese retrospective study J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-25 Panpan Fang, Kaijie Gao, Junmei Yang, Tiewei Li, Qianqian Sun, Zhiming Shan, Yingyuan Wang
To analyse the clinical characteristics and risk factors for bloodstream infections (BSIs) caused by carbapenem-resistant Enterobacteriaceae (CRE) in neonates. This single-centre, retrospective study included all patients with BSIs admitted to a neonatal intensive care unit between 1 January 2015 and 30 April 2022. The clinical and microbiological data of patients were collected; predictors of 30-day
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Co-existence of tmexCD2-toprJ2 and blaNDM-1 on a single plasmid carried by Raoultella ornithinolytica isolated from public garbage bins J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-24 Jie Li, Xiaoqian Long, Hui Lin, Caihong Song, Guoping Zhao, Biao Tang
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Coexistence of virulent and multidrug-resistant plasmids in an uropathogenic Escherichia coli J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-24 Yongli Wu, Ziyao Li, Zichen Lei, Jiankang Zhao, Yulin Zhang, Xinmeng Liu, Yanning Hu, Feilong Zhang, Binghuai Lu
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Candida glabrata hospital isolate from Lebanon reveals micafungin resistance associated with increased chitin and resistance to a cell surface disrupting agent. J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-24 Nour Fattouh, Roy A. Khalaf, Rola Husni
The aim of this study was to identify the resistance mechanisms to micafungin and fluconazole in a clinical isolate of . The isolate was whole genome sequenced in order to identify amino acid changes in key proteins involved in antifungal resistance and the isolate was further characterized by pathogenicity related phenotypic assays that supported the sequencing results. Amino acid substitutions were
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Hybrid genome assembly of colistin-resistant mcr-1.5-producing Escherichia coli ST354 reveals phylogenomic pattern associated with urinary tract infections in Brazil J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-24 Bruna Fuga, Fábio P. Sellera, Fernanda Esposito, Quézia Moura, Marcelo Pillonetto, Nilton Lincopan
The rapid and global spread of carrying genes at the human-animal-environmental interface has become a serious global public health problem. To perform a genomic investigation of a colistin-resistant strain (14005RM) causing urinary tract infection, using a hybrid de novo assembly of Illumina/Nanopore sequence data, presenting phylogenomic insights into relationship with -positive strains circulating
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Coexistence of blaNDM-5, blaCTX-M-15, blaOXA-232, blaSHV-182 genes in multidrug-resistant K. pneumoniae ST437-carrying OmpK36 and OmpK37 porin mutations: First report in Italy J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-24 Sascia Di Marcantonio, Mariagrazia Perilli, Giovanni Alloggia, Bernardetta Segatore, Gianfranca Miconi, Gianfranco Bruno, Patrizia Frascaria, Alessandra Piccirilli
is a common cause of severe hospital-acquired infections. In the present study, we have characterised the whole-genome of two ST437 belonging to the clonal complex CC258. The whole-genome sequencing was performed by MiSeq Illumina, with a 2 × 300bp paired-end run. ResFinder 4.4.2 was used to detect acquired antimicrobial resistance genes (ARGs) and chromosomal mutations. Mobile genetic elements (plasmids
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Evaluation of clinical and microbiological factors related to mortality in patients with Gram-negative bacterial infections treated with ceftazidime–avibactam: A prospective multicentric cohort study J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-09 Beatriz Arns, Guilherme Geraldo Lovato Sorio, Tarsila Vieceli, Dariane Pereira, Ândrea Celestino de Souza, Priscila Lamb Wink, Julia Hoefel Paes, Leonardo David, Fernanda Barboza, Stella Hickmann, Gustavo Alves, Antônio Cândido Santos, Anelise da Rosa, Marcelle Duarte Alves, Cibele Massotti Magagnin, Eduardo Gomes, Alexandre Prehn Zavascki, Maria Helena Rigatto
This study aimed to evaluate the clinical and microbiological risk factors associated with mortality in patients treated with ceftazidime–avibactam for carbapenem-resistant Gram-negative bacterial infections. This multicentric prospective cohort study included hospitalized adult patients with a microbiologically confirmed infection treated with ceftazidime–avibactam for ≥48 hours. The clinical and
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Persistence and evolution of linezolid- and methicillin-resistant Staphylococcus epidermidis ST2 and ST5 clones in an Italian hospital J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-07 Marzia Cinthi, Sonia Nina Coccitto, Antonella Pocognoli, Guido Zeni, Annarita Mazzariol, Alessandra Di Gregorio, Carla Vignaroli, Andrea Brenciani, Eleonora Giovanetti
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Transferable linezolid resistance genes (optrA and poxtA) in enterococci derived from livestock compost at Japanese farms J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-07 Akira Fukuda, Chie Nakajima, Yasuhiko Suzuki, Masaru Usui
Linezolid is a last-resort antimicrobial in human clinical settings to treat multidrug-resistant Gram-positive bacterial infections. Mobile linezolid resistance genes (, and ) have been detected in various sources worldwide. However, the presence of linezolid-not-susceptible bacteria and mobile linezolid resistance genes in Japan remains uncertain. Therefore, we clarified the existence of linezolid-not-susceptible
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In vitro activity of cefiderocol against Gram-negative pathogens isolated from people with cystic fibrosis and bronchiectasis J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-07 Michael M Tunney, J Stuart Elborn, Chloe S McLaughlin, Christopher M Longshaw
Gram-negative pathogens causing respiratory infection in people with cystic fibrosis and bronchiectasis are becoming progressively more resistant to conventional antibiotics. Although cefiderocol is licenced for the treatment of infections due to Gram-negative organisms, there are limited data on the activity of cefiderocol against pathogens associated with chronic respiratory diseases. The aim of
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Global distribution of heterogeneous vancomycin-intermediate Staphylococcus aureus strains (1997–2021): a systematic review and meta-analysis J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-07 Masoud Keikha, Mohsen Karbalaei
Heterogeneous vancomycin-intermediate is considered one of the main causes in treatment failure of vancomycin, which leads to poor clinical outcomes. Herein, we comprehensively evaluated characteristics such as global prevalence, trend, and genetic backgrounds of these strains. In this study, we conducted a meta-analysis based on PRISMA checklist 2020. In the beginning, global databases were searched
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Evaluation of antibiofilm activity of cefiderocol alone and in combination with imipenem against Pseudomonas aeruginosa J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-06 Caterina Ferretti, Noemi Violeta Poma, Mariano Bernardo, Laura Rindi, Novella Cesta, Arianna Tavanti, Carlo Tascini, Mariagrazia Di Luca
The main aim of this study was to evaluate the antibiofilm activity of cefiderocol alone and in combination with imipenem versus sessile cells of , assessing a potential synergistic bactericidal effect. Ten clinical isolates from infected implants and bloodstream were included in the study. Cefiderocol was tested alone and in combination with imipenem on 24 hour-old biofilm formed on porous glass beads
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In vitro antimicrobial susceptibility data of global meropenem-resistant Acinetobacter baumannii isolates causing pneumonia: Data from the Antimicrobial Testing Leadership and Surveillance Program, 2014–2021, and re-estimations of susceptibility breakpoints and appropriate dosages of important antibiotics for pneumonia treatment J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-06 Shun-Chung Hsueh, Yu-Tsung Huang, Wen-Chien Ko, I-Min Liu, Po-Chuen Hsieh, Shio-Shin Jean
To evaluate the susceptibility of globally pneumonia-causing meropenem-resistant (MEM-R) isolates against important antibiotics and estimate appropriate dosages of indicated antibiotics. We extracted the 2014–2021 Antimicrobial Testing of Leadership Surveillance database regarding the susceptibility of MEM-R isolates causing pneumonia against important antibiotics. The susceptibility and carbapenemase-encoding
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Risk factors associated with mcr-1 colistin-resistance gene in Escherichia coli broiler samples in northern Jordan J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-06 Mohammad H. Gharaibeh, Sahba Y. Al Sheyab, Shawkat Q. Lafi, Eman M. Etoom
The purpose of this study was to determine the prevalence of colistin-resistant carrying , and to identify risk factors associated with gene-mediated resistance. In total, 385 cloacal samples were collected from 125 broiler farms and a questionnaire containing information about each farm was designed and filled. Most of the antibiotics used in the disk diffusion method were highly resistant in all
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Evaluation of the therapeutic effect of a novel bacteriophage in the healing process of infected wounds with Klebsiella pneumoniae in mice J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-01 Fatemeh Zeynali Kelishomi, Farhad Nikkhahi, Samira Amereh, Fatemeh Ghayyaz, Seyed Mahmoud Amin Marashi, Amir Javadi, Gholamhassan Shahbazi, Mohadeseh Khakpour
Bacterial wound infections have recently become a threat to public health. The emergence of multidrug-resistant (MDR) strains of highlights the need for a new treatment method. The effectiveness of bacteriophages has been observed for several infections in animal models and human trials. In this study, we assessed the effectiveness of bacteriophages in the treatment of wound infections associated with
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Prevalence and molecular characteristics of ceftazidime-avibactam resistance among carbapenem-resistant Pseudomonas aeruginosa clinical isolates J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-01 Yili Chen, Guoxiu Xiang, Pingjuan Liu, Xianling Zhou, Penghao Guo, Zhongwen Wu, Juhua Yang, Peisong Chen, Junqi Huang, Kang Liao
Resistance against ceftazidime-avibactam (CZA) in carbapenem-resistant (CRPA) is emerging. This study was aimed at detecting the prevalence and molecular characteristics of CZA-resistant CRPA clinical isolates in Guangdong Province, China. The antimicrobial susceptibility profile of these strains was determined. A subset of 16 CZA-resistant CRPA isolates was analysed by whole-genome sequencing (WGS)
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Diversity of Staphylococcus aureus associated with mastitis from dairy cows in Rwanda J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-01 Helga Keinprecht, Emmanuel Irimaso, Adriana Cabal Rosel, Beatrix Stessl, Christophe Ntakirutimana, Lydia Marek, Otto W. Fischer, Michael P. Szostak, Jennifer Zöchbauer, Thomas Wittek, Elke Müller, Amelie Desvars-Larrive, Andrea T. Feßler, Sascha D. Braun, Stefan Schwarz, Joachim Spergser, Monika Ehling-Schulz, Stefan Monecke, Ralf Ehricht, Werner Ruppitsch, Tom Grunert, Igor Loncaric
The objective of the present study was to examine the diversity of from mastitis milk samples of cows in Rwanda. A total of 1080 quarter milk samples from 279 dairy cows were collected in 80 different farms from all five provinces of Rwanda. In total, 135 isolates were obtained and subjected to genotyping ( typing, DNA microarray, whole-genome sequencing (WGS)), antimicrobial susceptibility testing
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A clade of Streptococcus pneumoniae clonal complex 320 with increased tolerance to β-lactam antibiotics in a Chinese metropolitan city J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-01 Qiuwei Yi, Liqiang Li, Heping Wang, Chunqing Zhu, Yunsheng Chen, Liang Yang, Yuejie Zheng, Yonghong Yang, Yanmin Bao
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Acquisition of a stable and transferable plasmid coharbouring hypervirulence and MDR genes with low fitness cost: Accelerating the dissemination of ST11-KL64 CR-HvKP J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-02-01 Binghui Huo, DanDan Wei, QiSen Huang, Shanshan Huang, LinPing Fan, Ping Li, Jiehui Qiu, Qun Ren, ChunPing Wei, Yang Liu
This study aimed to delineate the ability of a plasmid, pS130–4, which harboured both hypervirulence and multidrug resistance genes, to disseminate within , as well as its potential formation mechanism. We employed whole-genome sequencing to decipher the genetic architecture of pS130–4. Its capability to conjugate and transfer was assessed through a series of experiments, including plasmid stability
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Letter in response to first case of persistent Stenotrophomonas maltophilia bacteremia due to septic thrombosis successfully treated with a Cefiderocol-containing regimen J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-01-26 Gayatree Nayak, Sushtree Sarathi, Bijayini Behera, Ashoka Mahapatra, Jayanti Jena, Srujana Mohanty
Abstract not available
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Genomic surveillance of carbapenem-resistant Klebsiella pneumoniae reveals a prolonged outbreak of extensively drug-resistant ST147 NDM-1 during the COVID-19 pandemic in the Apulia region (Southern Italy) J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-01-26 Daniela Loconsole, Anna Sallustio, Davide Sacco, Marilina Santantonio, Daniele Casulli, Domenico Gatti, Marisa Accogli, Antonio Parisi, Riccardo Zagaria, Vito Colella, Francesca Centrone, Maria Chironna
The recent worldwide spread of New Delhi metallo–beta-lactamase-producing (NDM-KP) in health-care settings remains a concern. The aim of the study was to describe an outbreak of extensively drug-resistant ST147 NDM-1-KP in the Apulia region of Southern Italy that occurred between 2020 and 2022 through genomic surveillance of carbapenem-resistant . A total of 459 carbapenem-resistant KP isolates collected
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Successful spread of mcr-1-bearing IncX4 plasmids is associated with variant in replication protein of IncX4 plasmids J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-01-26 Lingxian Yi, Kaiyang Yu, Guolong Gao, Rongmin Zhang, Luchao Lv, Daojin Yu, Jun Yang, Jian-Hua Liu
IncX4 plasmids are one of the most epidemiologically successful vehicles for spread. Here we found that the IncX4 plasmids carried two different replication proteins encoded by genes and , respectively, but was only carried by IncX4 plasmid encoding . The copy number of encoding plasmids (3.15 ± 0.9 copies) are higher than that of encoding plasmids (0.85 ± 0.5 copies). When was cloned into IncX4 plasmid
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Global-PPS targets for antimicrobial stewardship in paediatric patients at hospitals in Sanandaj, Western Iran, compared with Southeast Asian and European hospitals J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-01-26 Jafar Soltani, Shirin Behzadi, Ines Pauwels, Herman Goossens, Ann Versporten, Global-PPS Group Members
Point prevalence surveys (PPS) provide valuable data on patterns of hospital antimicrobial administration. To identify quality improvement indicators, we evaluated antimicrobial prescribing patterns in children and neonates admitted to three referral centres in Sanandaj, Western Iran, and compared these with Southeast Asian and European paediatric benchmark data. The standardised Global-PPS was performed
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Corrigendum to “Molecular typing and antimicrobial resistance of group B Streptococcus clinical isolates in Saudi Arabia” [Journal of Global Antimicrobial Resistance 35 (2023) 244-251] J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-01-24 Maha Alzayer, Manal M. Alkhulaifi, Ahmed Alyami, Mohammed Aldosary, Abdulaziz Alageel, Ghada Garaween, Atef Shibl, Arif M Al-Hamad, Michel Doumith
Abstract not available
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Clone dissemination of IncX3 plasmid carrying blaNDM-1 in ST76 carbapenem resistance Klebsiella pneumoniae and bactericidal efficiency of aztreonam combined with avibactam in vitro and in vivo J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-01-24 Tianqun Huo, Ziyan Kong, Guokai Dong, Shulong Zhao, Xuemei Liu, Fei Jiang
The rapid spread of the New Delhi Metal-β-lactamase-1 () gene in poses a substantial challenge to pediatric therapeutic care. Here, we aimed to characterise the IncX3-type plasmid carrying the gene in ST76 carbapenem resistance (CRKP) strains and assess the in vitro and in vivo bactericidal efficacy of Aztreonam (ATM) combined with Avibactam (AVI) (ATM+AVI) against CRKP The broth microdilution method
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Genomic resistant determinants of multidrug-resistant Campylobacter spp. isolates in Peru J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-01-24 Francesca Schiaffino, Craig T. Parker, Maribel Paredes Olortegui, Ben Pascoe, Katia Manzanares Villanueva, Paul F. Garcia Bardales, Evangelos Mourkas, Steven Huynh, Pablo Peñataro Yori, Lucero Romaina Cachique, Hannah K. Gray, Guillermo Salvatierra, Hermann Silva Delgado, Samuel K. Sheppard, Kerry K. Cooper, Margaret N. Kosek
Antimicrobial resistant (AMR) is a global health threat; however, there is limited information on genomic determinants of resistance in low- and middle-income countries. We evaluated genomic determinants of AMR using a collection of whole genome sequenced and isolates from Iquitos, Peru. isolates from two paediatric cohort studies enriched with isolates that demonstrated resistance to ciprofloxacin
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Therapeutic drug monitoring of imipenem/cilastatin and meropenem in critically ill adult patients J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-01-23 Xi You, Qing Dai, Jing Hu, Mingjie Yu, Xiaowen Wang, Bangbi Weng, Lin Cheng, Fengjun Sun
To investigate the factors influencing imipenem/cilastatin (IMI) and meropenem (MEM) concentrations in critically ill adult patients and the role of these concentrations in the clinical outcome. Plasma trough concentrations of IMI and MEM were detected by high-performance liquid chromatography. A target value of 100%-time above MIC was used for the drugs. A total of 186 patients were included, with
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Molecular epidemiological characteristics of carbapenem-resistant Pseudomonas aeruginosa clinical isolates in southeast Shanxi, China J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-01-23 Yang Bai, Yan-e Gong, Fangfang Shen, Hui Li, Yan Cheng, Jinying Guo, Guangming Liu, Ai-fang Ji
Infection by carbapenem-resistant is a serious clinical problem worldwide. However, the molecular epidemiology of the clinical isolates varies depending on the region. This study was conducted to analyse the resistance phenotype and clarify the genetic and epidemiological properties of CRPA clinical isolates from southeast Shanxi, China. Methods: Fifty-seven isolates of CRPA were collected from a hospital
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Characterisation of highly virulent and colistin-resistant ST367-KL1 Klebsiella quasipneumoniae subsp. similipneumoniae Strain J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-01-23 Yu-ting Li, Yang-hua Xiao, Yanling Liu, Niya Hu, Chengwei Wu, Xiaotian Huang, Lingbing Zeng
To elucidate the characteristics of a colistin-resistant and hypervirulent subsp. strain (KP8) using whole genome sequencing and various phenotypic assays. Antimicrobial susceptibility testing was performed using broth microdilution. Whole genome sequencing and comparative genomics were utilised to elucidate genomic characteristics. Phenotypic assays to evaluate virulence factors included measurements
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Genomic insights into a blaNDM-5-carrying Escherichia coli ST167 isolate recovered from faecal sample of a healthy individual in China J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-01-23 Lirong Li, Yawen Zhang, Hao Guo, Jing Yang, Fang He
Objectives : Since its discovery, blaNDM-5 has spread widely among Escherichia coli strains in clinical patients, causing carbapenem resistance. Here we report the complete genome sequence of an NDM-5-producing E. coli strain isolated from fecal sample of a healthy individual in Hangzhou, China. Methods : The whole-genome sequence of E. coli CREC8 was obtained utilizing both the Nanopore sequencer
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Genomic scan of a healthcare-associated NDM-1-producing Citrobacter freundii ST18 isolated from a green sea turtle impacted by plastic pollution J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-01-22 Valentina Aravena-Ramírez, Danny Fuentes-Castillo, Sibelle T. Vilaça, Daphne W. Goldberg, Fernanda Esposito, Taiana T. Silva-Pereira, Herrison Fontana, Fábio P. Sellera, Nilton Lincopan
Background Carbapenemase-producing Citrobacter freundii has been reported as a leading cause of healthcare-associated infections. Particularly, C. freundii belonging to the sequence type (ST) 18 is considered to be an emerging nosocomial clone. Objective To report the genomic background and phylogenomic analysis of a multidrug-resistant NDM-1-producing C. freundii ST18 (strain CF135931) isolated from
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The fexA gene in Campylobacter: whether the spread has occurred among various hosts in eastern China J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-01-22 Pingyu Huang, Chong Chen, Xiaoqi Zang, Qinyue Jiang, Yilin Lv, Hongyue Lv, Yanying Qin, Xinan Jiao, Jinlin Huang
The emergence of the florfenicol resistance gene in poses a serious threat to public health, but the extent of the spread of in from various hosts has not been well understood. This study aimed to investigate the in isolates from different hosts. PCR was used to identify -positive from different hosts during 2008–2019 in China, and the -positive isolates were characterized by susceptibility tests,
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Genomic characteristics of two strains of ESBL-producing Klebsiella pneumoniae ST268 isolated from different samples of one patient J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-01-22 Chao Chen, Wei Wang, Jiechang Zhang, Limei Zhang, Jianhua Zhao, Jinming Deng, Wang Li, Xiaobin Li, Wenyan Zhuo, Lian Huang, Jing Chen
This study reports the whole-genome sequences of two strains of extended-spectrum beta-lactamase (ESBL)-producing and multidrug-resistant (MDR) ST268 and explores their acquired antibiotic resistance genes (ARGs) and the mobile genetic elements (MGEs). Two strains of ST268 were isolated from different samples of one patient. Assessment of antimicrobial susceptibility was performed, and then whole-genome
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Molecular characteristics and antimicrobial resistance of invasive pneumococcal isolates from children in the post-13-valent pneumococcal conjugate vaccine era in Shenzhen, China J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-01-22 Lu Huang, Yanmin Bao, Qiuwei Yi, Dingle Yu, Heping Wang, Hongmei Wang, Zihao Liu, Chunqing Zhu, Qing Meng, Yunsheng Chen, Wenjian Wang, Jikui Deng, Gang Liu, Yuejie Zheng, Yonghong Yang
This study aimed to evaluate the molecular epidemiology and antimicrobial resistance of invasive pneumococcal isolates from children in Shenzhen, China, in the early stage of the pneumococcal 13-valent conjugated vaccine (PCV-13) era from 2018 to 2020. Invasive pneumococcal strains were isolated from hospitalized children with invasive pneumococcal diseases (IPDs) from January 2018 to December 2020
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Differences in antibiotic exposures and antibiotic exposure risks for methicillin-resistant Staphylococcus aureus between patients in an acute-care hospital and residents in its closely affiliated intermediate- and long-term care facilities J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-01-11 Wei Zhang, Kala Kanagasabai, Jocelyn Koh, Brenda Ang, Angela Chow
Abstract not available
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Erratum to “Outbreak of high-risk XDR CRAB of international clone 2 (IC2) in Rio Janeiro, Brazil” [Journal of Global Antimicrobial Resistance 34 (2023) 91-98] J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-01-11 Sérgio M. Morgado, Érica L. Fonseca, Fernanda S. Freitas, Nathalia S. Bighi, Priscila P.C. Oliveira, Priscilla M. Monteiro, Lorena S. Lima, Bianca P. Santos, Maria A.R. Sousa, Adriana O. Assumpção, Luiz A. Mascarenhas, Ana Carolina P. Vicente
Abstract not available
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Dalbavancin real-life utilization among diabetic patients suffering from infections in Italy and Spain: The DALBADIA retrospective cohort study J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-01-10 Laura Morata Ruiz, Alessandro Ruggieri, Marco Falcone, Juan Pasquau Liaño, Ivan Gentile, Miguel Salavert Lletí, Leonor Moreno Núñez, Antonio Cascio, Carlo Tascini, Maria Loeches Yagüe, Francesco Giuseppe De Rosa, Alessandra Ori, Alessandro Comandini, Agnese Cattaneo, Paolo Antonio Grossi, DALBADIA study group
To retrospectively describe the patterns of use of dalbavancin for treating infections in diabetic patients in Italian and Spanish standard clinical practice. DALBADIA [NCT04959799] was a multicentre, observational, retrospective cohort study, conducted in Italy and Spain. The study enrolled 97 adults with type 1 or 2 diabetes mellitus, treated with dalbavancin as per standard clinical practice for
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The integrative and conjugative element ICECiPOL15 mediates horizontal transfer of β-lactam resistance gene in Chryseobacterium indoltheticum POL15 J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-01-05 Xiaoyan Zhu, Xiangpeng Wang, Fengtian Wang, Xinyi Tian, Jingxiang Pang
The dissemination of antibiotic resistance genes (ARGs) from the environment, including agricultural sources, is of increasing concern. In this study, we examined the antibiotic resistance profile and genomic sequence of a strain of obtained from an agricultural location The multidrug-resistant bacterial strain POL15 was isolated from the wastewater of a livestock farm in China. Whole-genome sequencing
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An evaluation of the five rights antibiotic safety before and during COVID-19 at an NHS Foundation Trust in the United Kingdom J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2024-01-03 Rasha Abdelsalam Elshenawy, Nkiruka Umaru, Zoe Aslanpour
Antimicrobial Resistance (AMR) poses a significant global health threat, with AMR-related deaths projected to reach 10 million annually by 2050. The COVID-19 pandemic has further exacerbated this crisis. This study focuses on evaluating the 'Five Rights of Antibiotic Safety' in an NHS Foundation Trust in England, assessing the impact of the COVID-19 pandemic on antibiotic prescribing and Antimicrobial
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Current status of Helicobacter pylori resistance to clarithromycin and levofloxacin in Vietnam: Results from molecular analysis of gastric biopsy specimens J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2023-12-29 Van Huy Tran, Thi Mai Ngan Nguyen, Phan Tuong Quynh Le, Thi Huyen Thuong Nguyen, Thi Chau Loan Nguyen, Thi Minh Thi Ha
The management of in Vietnam is becoming progressively more difficult due to increasing antibiotic resistance, particularly to clarithromycin (CLR) and levofloxaxin (LVX). In Vietnam, the selection of an eradication regimen is predominantly based on empirical evidence. However, molecular analysis aimed at identifying antibiotic-resistant genotypes is a promising method in antibiotic susceptibility
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First detection in Spain of NDM-1-producing Pseudomonas aeruginosa in two patients transferred from Ukraine to a university hospital J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2023-12-28 Marta Hernández-García, Margarita Cabello, Manuel Ponce-Alonso, Pedro M. Herrador-Gómez, Francesca Gioia, Javier Cobo, Rafael Cantón, Patricia Ruiz-Garbajosa
Carbapenemase-mediated carbapenem resistance in is a relevant health problem. We detected for the first time in Spain two clinical NDM-producing (NDM-Pa) isolates in two Ukrainian patients admitted to our hospital between April and August 2022. Antimicrobial susceptibility was studied by microdilution and MIC gradient strips (EUCAST-2022 criteria). Carbapenemase genes were detected by the Xpert Carba-R
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Characterization and multilocus sequence typing of Clostridium perfringens isolated from patients with diarrhoea and food poisoning in Tai'an region, China J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2023-12-28 Yanyan Ren, Xiaoyang Lv, Wenping Xu, Yanyan Li, Lixue Liu, Xinyue Kong, Hairong Wang
() is a significant opportunistic pathogen. This study aims to examine the occurrence of in patients with diarrhoea and food poisoning and compare the genetic similarities with strains found in poultry retail markets and poultry farms in the same city (Tai'an, China). was isolated from 30 human faecal samples and genotyped using multiplex PCR. The antimicrobial susceptibility test was conducted using
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Induction of proteome changes involved in the cloning of mcr-1 and mcr-2 genes in Escherichia coli DH5-α strain to evaluate colistin resistance J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2023-12-27 Hadi Feizi, Maryam Alizadeh, Hadi Azimi, Ehsaneh Khodadadi, Fadhil S. Kamounah, Khudaverdi Ganbarov, Reza Ghotaslou, Mohammad Ahangarzadeh Rezaee, Hossein Samadi Kafil
Plasmid genes, termed mobile colistin resistance-1 () and mobile colistin resistance-2 (), are associated with resistance to colistin in (). These genes result in a range of protein modifications contributing to colistin resistance. This study aims to discern the proteomic characteristics of –carrying and genes. Furthermore, it evaluates the expression levels of various proteins under different conditions
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Characteristics of Klebsiella pneumoniae pyogenic liver abscess from 2010–2021 in a tertiary teaching hospital of South China J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2023-12-27 Jinqing Liu, Yao Liu, Chunhui Li, Wenting Peng, Chuan Jiang, Shifang Peng, Lei Fu
Pyogenic liver abscess (PLA) is a severe and potentially fatal infectious disease. () is the predominant pathogen responsible for PLA. This study aims to investigate the clinical characteristics and prognostic factors of –induced pyogenic liver abscess (KP-PLA), particularly those caused by carbapenem-resistant (CRKP). Analyses were performed on PLA patients from January 2010 to December 2021, to investigate
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Whole genome sequencing of carbapenemase-producing Proteus mirabilis with Salmonella Genomic Island, Korea J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2023-12-27 Jinkyung Yu, JinSeok Kim, Jungsun Park, Junyoung Kim, Sang-Hun Park, Su Jin Jeon, Young Ok Hwang, Jib-Ho Lee
Abstract not available
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Multidrug-resistant pathogens contaminate river water used in irrigation in disenfranchised communities J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2023-12-27 Marwan Osman, Dina Daaboul, Anahita Ghorbani Tajani, Khaled El Omari, Bledar Bisha, Jouman Hassan, Casey L. Cazer, Kathryn J. Fiorella, Nabil Karah, Aula Abbara, Monzer Hamze, Kevin J. Cummings, Thierry Naas, Issmat I. Kassem
The contamination of fresh surface waters poses a significant burden on human health and prosperity, especially in marginalized communities with limited resources and inadequate infrastructure. Here, we performed in-depth genomic analyses of multidrug-resistant bacteria (MDR-B) isolated from Al-Oueik river water that is used for irrigation of agricultural fields in a disenfranchised area that also
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In vitro activity of aztreonam-avibactam and comparators against Metallo-β-Lactamase-producing Enterobacterales from ATLAS Global Surveillance Program, 2016–2020 J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2023-12-27 Gian Maria Rossolini, Francis F. Arhin, Michal Kantecki
Metallo-β-lactamase (MBL)-producing Enterobacterales are a major challenge worldwide due to limited treatment options. Aztreonam-avibactam (ATM-AVI), which is under clinical development, has shown activity against MBL-positive isolates. This study evaluated the prevalence of MBL producers and the nature of enzymes among a global collection of clinical isolates of Enterobacterales from the Antimicrobial
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Genomic characterization of blaVIM-11-harbouring plasmids recovered from Pseudomonas aeruginosa J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2023-12-27 Alan Elena, Daniela Cejas, Gabriel Gutkind, Marcela Radice
Objectives To the best of our knowledge, no genomic descriptions of blaVIM-11-harbouring plasmids are available in literature so far. The aim of this study was to describe the genomic features of three blaVIM-11-harbouring plasmids recovered from Pseudomonas aeruginosa isolated in Argentina in different periods. Methods blaVIM-11-harbouring plasmids from three clinical P. aeruginosa isolates were transferred
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Extensively drug-resistant Enterobacter ludwigii co-harbouring MCR-9 and a multicopy of blaIMP-1 in South Korea J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2023-12-27 Jin Yang Baek, Jinyoung Yang, Jae-Hoon Ko, Sun Young Cho, Kyungmin Huh, Doo Ryeon Chung, Kyong Ran Peck, Kwan Soo Ko, Cheol-In Kang
In this study, we describe an clinical isolate that is resistant to both carbapenems and colistin in South Korea. Antimicrobial susceptibility testing revealed that CRE2104-31 was non-susceptible to all tested antibiotics except fosfomycin. Whole genome sequencing identified a 323-kbp IncHI2 plasmid, pCRE2104-31a, that was co-harbouring mobile colistin resistance ( and . In comparison with other full
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The first vanE-type vancomycin resistant Enterococcus faecalis isolates in Norway – phenotypic and molecular characteristics J. Glob. Antimicrob. Resist. (IF 4.6) Pub Date : 2023-12-27 Mushtaq AL Rubaye, Jessin Janice, Jørgen Vildershøj Bjørnholt, Iren H. Löhr, Arnfinn Sundsfjord, Kristin Hegstad
We aimed to characterize the cluster and its genetic support in the first Norwegian -type isolates and assess genetic relatedness to other isolates. Two -type vancomycin resistant (-VRE) isolates (E1 and E2) recovered from the same patient 30 months apart were examined for antimicrobial susceptibility, genome sequence, vancomycin resistance induction, transferability, genome mutation rate, and phylogenetic