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Pretreatment quality of life and survival in patients with lung cancer: a systematic review and meta-analysis BMC Cancer (IF 3.8) Pub Date : 2024-04-18 Taro Okayama, Katsuyoshi Suzuki, Shinichiro Morishita, Junichiro Inoue, Takashi Tanaka, Jiro Nakano, Takuya Fukushima
Although many studies have explored the correlation between quality of life and survival, none have reported this relationship for specific cancers assessed at distinct time points. This meta-analysis aimed to investigate the impact of pretreatment Global Quality of Life (QOL) and functioning QOL, including physical, social, role, emotional, and cognitive QOLs, on mortality risk in patients with lung
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The effect of internet-administered support (carer eSupport) on preparedness for caregiving in informal caregivers of patients with head and neck cancer compared with support as usual: a study protocol for a randomized controlled trial BMC Cancer (IF 3.8) Pub Date : 2024-04-18 Birgitta Johansson, Åsa Cajander, Awais Ahmad, Emma Ohlsson-Nevo, Per Fransson, Brith Granström, Louise von Essen, Ulrica Langegård, Mona Pettersson, Anna Henriksson, Ylva Tiblom Ehrsson
Informal caregivers (ICs) of patients with cancer provide essential and mainly uncompensated care. A self-perceived preparedness to care for the patient is associated with a lower caregiver burden, described as the extent to which caregiving is perceived as having adverse effects on IC functioning and well-being. ICs’ well-being is associated with patient-perceived quality of care, suggesting that
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Creatine supplementation and resistance training to preserve muscle mass and attenuate cancer progression (CREATINE-52): a protocol for a double-blind randomized controlled trial BMC Cancer (IF 3.8) Pub Date : 2024-04-18 Adriana M Coletta, Lea Haverbeck Simon, Kelsey Maslana, Sarah Taylor, Kish Larson, Pamela A Hansen, Vinay Mathew Thomas, Cornelia M Ulrich, Manish Kohli, Jonathan Chipman, Umang Swami, Sumati Gupta, Benjamin L Maughan, Neeraj Agarwal
Muscle mass is important for metastatic prostate cancer survival and quality of life (QoL). The backbone of treatment for men with metastatic castration sensitive prostate cancer (mCSPC) is androgen deprivation therapy (ADT) with an androgen signaling inhibitor. ADT is an effective cancer treatment, but it facilitates significant declines in muscle mass and adverse health outcomes important to mCSPC
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Development and validation of a nomogram for predicting sever cancer-related fatigue in patients with cervical cancer BMC Cancer (IF 3.8) Pub Date : 2024-04-18 ZhiHui Gu, ChenXin Yang, Ke Zhang, Hui Wu
Cancer-related fatigue (CRF) has been considered the biggest influencing factor for cancer patients after surgery. This study aimed to develop and validate a nomogram for severe cancer-related fatigue (CRF) patients with cervical cancer (CC). A cross-sectional study was conducted to develop and validate a nomogram (building set = 196; validation set = 88) in the Department of Obstetrics and Gynecology
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Effect of the STK11 mutation on therapeutic efficacy and prognosis in patients with non-small cell lung cancer: a comprehensive study based on meta-analyses and bioinformatics analyses BMC Cancer (IF 3.8) Pub Date : 2024-04-17 Ke Xu, Weinan Lu, Airu Yu, Hongwei Wu, Jie He
This study aimed to systematically analyze the effect of a serine/threonine kinase (STK11) mutation (STK11mut) on therapeutic efficacy and prognosis in patients with non-small cell lung cancer (NSCLC). Candidate articles were identified through a search of relevant literature published on or before April 1, 2023, in PubMed, Embase, Cochrane Library, CNKI and Wanfang databases. The extracted and analyzed
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Immune checkpoint inhibitors in Cancer patients with rheumatologic preexisting autoimmune diseases: a systematic review and meta-analysis BMC Cancer (IF 3.8) Pub Date : 2024-04-17 Xin Liu, Su Li, Liyuan Ke, Hongxia Cui
Patients with rheumatologic preexisting autoimmune disease (PAD) have not been enrolled in clinical trials of immune checkpoint inhibitors (ICIs). Therefore, the risks and benefits of ICI therapy in such patients are unclear. Herein, we investigated the safety and efficacy of ICIs in rheumatologic PAD patients through a meta-analysis. The PubMed, Cochrane Library, Embase and Web of Science databases
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Utility of bronchoscopically obtained frozen cytology pellets for next-generation sequencing BMC Cancer (IF 3.8) Pub Date : 2024-04-17 Chihiro Mimura, Rei Takamiya, Shodai Fujimoto, Takafumi Fukui, Atsuhiko Yatani, Jun Yamada, Mizuki Takayasu, Naoya Takata, Hiroki Sato, Kiyoko Fukuda, Koichi Furukawa, Daisuke Hazama, Naoko Katsurada, Masatsugu Yamamoto, Shingo Matsumoto, Koichi Goto, Motoko Tachihara
Next-generation sequencing (NGS) is essential for lung cancer treatment. It is important to collect sufficient tissue specimens, but sometimes we cannot obtain large enough samples for NGS analysis. We investigated the yield of NGS analysis by frozen cytology pellets using an Oncomine Comprehensive Assay or Oncomine Precision Assay. We retrospectively enrolled patients with lung cancer who underwent
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Chronic hyperglycemia and intracranial meningiomas BMC Cancer (IF 3.8) Pub Date : 2024-04-17 D. Orešković, A. Madero Pohlen, I. Cvitković, J.F. Alen, M. Raguž, A. Álvarez-Sala de la Cuadra, G.J. Bazarra Castro, Z. Bušić, I. Konstantinović, V. Ledenko, C. Martínez Macho, D. Müller, M. Žarak, N. Jovanov-Milosevic, D. Chudy, T. Marinović
Meningiomas are among the most common primary tumors of the central nervous system. Previous research into the meningioma histological appearance, genetic markers, transcriptome and epigenetic landscape has revealed that benign meningiomas significantly differ in their glucose metabolism compared to aggressive lesions. However, a correlation between the systemic glucose metabolism and the metabolism
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Correction: Pembrolizumab-based first-line treatment for PD-L1-positive, recurrent or metastatic head and neck squamous cell carcinoma: a retrospective analysis BMC Cancer (IF 3.8) Pub Date : 2024-04-17 Alessio Cirillo, Daniele Marinelli, Umberto Romeo, Daniela Messineo, Francesca De Felice, Marco De Vincentiis, Valentino Valentini, Silvia Mezi, Filippo Valentini, Luca Vivona, Antonella Chiavassa, Bruna Cerbelli, Daniele Santini, Paolo Bossi, Antonella Polimeni, Paolo Marchetti, Andrea Botticelli
Correction: BMC Cancer 24, 430 (2024) https://doi.org/10.1186/s12885-024-12155-3 Following publication of the original article [1], the authors noticed that Fig. 4 was a duplicate of Fig. 3. This correction article consists of the correct Fig. 3 and Fig. 4. Fig. 3 3A, PFS according to PD-L1 CPS classes; 3B, OS according to PD-L1 CPS classes; 3C, PFS in patients treated with pembrolizumab-based chemoimmunotherapy
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Phase I/II clinical trial of efficacy and safety of EGCG oxygen nebulization inhalation in the treatment of COVID-19 pneumonia patients with cancer BMC Cancer (IF 3.8) Pub Date : 2024-04-17 Xiaoyan Yin, Wanqi Zhu, Xiaoyong Tang, Guangjian Yang, Xianguang Zhao, Kaikai Zhao, Liyang Jiang, Xiaolin Li, Hong Zhao, Xin Wang, Yuanyuan Yan, Ligang Xing, Jinming Yu, Xiangjiao Meng, Hanxi Zhao
The antiviral drug Nirmatrelvir was found to be a key drug in controlling the progression of pneumonia during the infectious phase of COVID-19. However, there are very few options for effective treatment for cancer patients who have viral pneumonia. Glucocorticoids is one of the effective means to control pneumonia, but there are many adverse events. EGCG is a natural low toxic compound with anti-inflammatory
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Metabolic difference between patient-derived xenograft model of pancreatic ductal adenocarcinoma and corresponding primary tumor BMC Cancer (IF 3.8) Pub Date : 2024-04-17 Shi Wen, Xianchao Lin, Wei Luo, Yu Pan, Fei Liao, Zhenzhao Wang, Bohan Zhan, Jianghua Feng, Heguang Huang
Patients-derived xenograft (PDX) model have been widely used for tumor biological and pathological studies. However, the metabolic similarity of PDX tumor to the primary cancer (PC) is still unknown. In present study, we established PDX model by engrafting primary tumor of pancreatic ductal adenocarcinoma (PDAC), and then compared the tumor metabolomics of PC, the first generation of PDX tumor (PDXG1)
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The role of piRNAs in predicting and prognosing in cancer: a focus on piRNA-823 (a systematic review and meta-analysis) BMC Cancer (IF 3.8) Pub Date : 2024-04-16 Mohammad Taghizadeh, Tohid Jafari-Koshki, Vahid Jafarlou, Mortaza Raeisi, Leila Alizadeh, Yousef Roosta, Somaieh Matin, Rahele Jabari, Daniel Sur, Abbas Karimi
This article examines the potential of using liquid biopsy with piRNAs to study cancer survival outcomes. While previous studies have explored the relationship between piRNA expression and cancer patient outcomes, a comprehensive investigation is still lacking. To address this gap, we conducted a systematic review and meta-analysis of existing literature. We searched major online databases up to February
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Efficacy of salvage surgery versus re-irradiation for isolated regional lymph node recurrence in patients with nasopharyngeal carcinoma BMC Cancer (IF 3.8) Pub Date : 2024-04-16 Yuebing Chen, Yiping Huang, Xiaoqiang Chen, Zhiwei Chen, Xiane Peng, Shaojun Lin, Cheng Lin, Jingfeng Zong
To compare the clinical characteristics and prognoses of patients with isolated regional lymph node recurrent nasopharyngeal carcinoma (irrNPC) who underwent surgery or re-irradiation treatment. We retrospectively reviewed 124 irrNPC patients who underwent initial radiotherapy between January 2010 and December 2020. The staging of regional lymph node recurrence was as follows: 75.8% for rN1, 14.5%
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Detecting androgen receptor (AR), AR variant 7 (AR-V7), prostate-specific membrane antigen (PSMA), and prostate-specific antigen (PSA) gene expression in CTCs and plasma exosome-derived cfRNA in patients with metastatic castration-resistant prostate cancer (mCRPC) by integrating the VTX-1 CTC isolation system with the QIAGEN AdnaTest BMC Cancer (IF 3.8) Pub Date : 2024-04-16 Haiyan E. Liu, Meghah Vuppalapaty, Christian R. Hoerner, Colin P. Bergstrom, Michael Chiu, Clementine Lemaire, James Che, Amanpreet Kaur, Adam Dimmick, Sean Liu, Thomas J. Metzner, Menna Araya, Steve Crouse, Markus Sprenger-Haussels, Martin Schlumpberger, John T. Leppert, Siegfried Hauch, Elodie Sollier, Alice C. Fan
Therapies for metastatic castration-resistant prostate cancer (mCRPC) include targeting the androgen receptor (AR) with androgen receptor inhibitors (ARIs) and prostate-specific membrane antigen (PSMA). Having the ability to detect AR, AR splice variant 7 (AR-V7), or PSMA in circulating tumor cells (CTCs) or circulating exosomal cell-free RNA (cfRNA) could be helpful to guide selection of the appropriate
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Stereotactic ablative brachytherapy versus percutaneous microwave ablation as salvage treatments for lung oligometastasis from colorectal cancer BMC Cancer (IF 3.8) Pub Date : 2024-04-16 Yuliang Li, Zitong Chen, Shuhui Tian, Xujian Han, Changjun Wang, Yongzheng Wang, Bin Liu
The treatment for lung oligometastasis from colorectal cancer (CRC) remains challenging. This retrospective study aimed to compare the local tumor control, survival and procedure-related complications in CRC patients undergoing low-dose rate stereotactic ablative brachytherapy (L-SABT) versus percutaneous microwave ablation (MWA) for lung oligometastasis. Patients between November 2017 and December
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HAIC Combined with lenvatinib plus PD-1 versus lenvatinib Plus PD-1 in patients with high-risk advanced HCC: a real-world study BMC Cancer (IF 3.8) Pub Date : 2024-04-16 Xu Chang, Xinge Li, Peng Sun, Zhenfeng Li, Pengfei Sun, Shangkun Ning
The treatment of hepatocellular carcinoma (HCC) patients exhibiting high-risk characteristics (Vp4, and/or bile duct invasion, and/or tumor occupancy ≥ 50%) lacks standardized approaches and yields unfavorable results. This study endeavors to evaluate the safety, efficacy, and prognostic impacts of employing hepatic arterial infusion chemotherapy (HAIC), lenvatinib, and humanized programmed death receptor-1
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Exploring treatment outcomes in Stage II-III rectal cancer patients undergoing neoadjuvant therapy at a tertiary care center in Pakistan: a comprehensive analysis of pathological outcomes BMC Cancer (IF 3.8) Pub Date : 2024-04-16 Misbah Younus Soomro, Saqib Raza Khan, Hafiz Muhammad, Sujjawal Ahmad, Nawazish Zehra, Insia Ali, Mirza Rameez Samar, Arif Hameed, Munira Moosajee, Yasmin Abdul Rashid
Rectal cancer treatment has transformed in recent years, with neoadjuvant treatment (NT) and total neoadjuvant treatment (TNT) aiming to enhance pathological responses. This pioneering study in our country delves into rectal cancer management, offering crucial insights by examining pathological outcomes in patients treated with the NT and TNT approach, shaping the evolving landscape. In this retrospective-cohort
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Heterogeneous changes in gut and tumor microbiota in patients with pancreatic cancer: insights from clinical evidence BMC Cancer (IF 3.8) Pub Date : 2024-04-15 Feng Zhao, Anli Chen, Xiaotian Wu, Xiangyu Deng, Jiali Yang, Jianjiang Xue
Pancreatic cancer is the foremost contributor to cancer-related deaths globally, and its prevalence continues to rise annually. Nevertheless, the underlying mechanisms behind its development remain unclear and necessitate comprehensive investigation. In this study, a total of 29 fresh stool samples were collected from patients diagnosed with pancreatic cancer. The gut microbial data of healthy controls
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Proportion of cancer cases and deaths attributable to potentially modifiable risk factors in Peru BMC Cancer (IF 3.8) Pub Date : 2024-04-15 Jhony A. De La Cruz-Vargas, Willy Ramos, Willer Chanduví, Lucy E. Correa-López, Nadia Guerrero, Joan Loayza-Castro, Irene Tami-Maury, Diego Venegas
Limited evidence exists on the population attributable fraction (PAF) of cancer cases and deaths in Latin America. In Peru several studies have been published regarding the PAF of various risk factors and their associated diseases. The objective of this study was to estimate the fraction of cancer cases and deaths attributable to potentially modifiable risk factors in Peru in 2018, before the COVID-19
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The associates of anxiety among lung cancer patients: Dehydroepiandrosterone (DHEA) as a potential biomarker BMC Cancer (IF 3.8) Pub Date : 2024-04-15 Jia-Rong Wu, Vincent Chin -Hung Chen, Yu-Hung Fang, Ching-Chuan Hsieh, Shu-I Wu
Anxiety is a prevalent comorbidity in lung cancer (LC) patients associated with a decline in quality of life. Dehydroepiandrosterone (DHEA), a neuroactive steroid, levels rise in response to stress. Prior research on the association between DHEA and anxiety has yielded contradictory results and no study has investigated this association in LC patients. A total of 213 patients with LC were recruited
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Impact of hepatic inflammation and fibrosis on the recurrence and long-term survival of hepatitis B virus-related hepatocellular carcinoma patients after hepatectomy BMC Cancer (IF 3.8) Pub Date : 2024-04-15 Xiangyong Hao, Liangliang Xu, Xiang Lan, Bo Li, Hui Cai
Underlying liver disease is correlated with hepatocellular carcinoma (HCC) development in patients with hepatitis B virus (HBV) infection. However, the impact of hepatic inflammation and fibrosis on the patients’ prognoses remains unclear. The clinicopathological data of 638 HBV-infected patients with early-stage HCC between 2017 and 2019 were prospectively collected. Hepatic inflammation and fibrosis
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Exercise accelerates recruitment of CD8+ T cell to promotes anti-tumor immunity in lung cancer via epinephrine BMC Cancer (IF 3.8) Pub Date : 2024-04-15 Sai-Nan Miao, Meng-Qi Chai, Xiang-Yu Liu, Cheng-Yu Wei, Cun-Cun Zhang, Ning-Ning Sun, Qing-Ze Fei, Lin-Lin Peng, Huan Qiu
In recent years, there has been extensive research on the role of exercise as an adjunctive therapy for cancer. However, the potential mechanisms underlying the anti-tumor therapy of exercise in lung cancer remain to be fully elucidated. As such, our study aims to confirm whether exercise-induced elevation of epinephrine can accelerate CD8+ T cell recruitment through modulation of chemokines and thus
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Survival analysis of Sudanese oral squamous cell carcinoma patients with field of cancerization BMC Cancer (IF 3.8) Pub Date : 2024-04-15 Yousif Eltohami, Ahmed Suleiman
The late presentation and diagnosis of OSCC account for the large number of patients with the advanced form of the disease. In Sudan, cases with delayed presentation, particularly those with risk factors such as Toombak dipping and alcohol consumption, frequently present with extensive lesions and a wide area of Field cancerization which characterized by the presence of genetic and epigenetic changes
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Astragaloside IV-PESV inhibits prostate cancer tumor growth by restoring gut microbiota and microbial metabolic homeostasis via the AGE-RAGE pathway BMC Cancer (IF 3.8) Pub Date : 2024-04-15 Xujun You, Junfeng Qiu, Qixin Li, Qing Zhang, Wen Sheng, Yiguo Cao, Wei Fu
Prostate cancer (PCa) is becoming the most common malignancy in men worldwide. We investigated the effect of astragaloside IV combined with PESV on the gut microbiota and metabolite of PCa mice and the process of treating PCa. Nude mice were genetically modified to develop tumors characteristic of PCa. The treatment of PCa mice involved the administration of a combination of astragaloside IV and peptides
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Retraction Note: Propofol suppresses growth, migration and invasion of A549 cells by down-regulation of miR-372 BMC Cancer (IF 3.8) Pub Date : 2024-04-15 Hai Sun, Dengyu Gao
Retraction Note: BMC Cancer 18, 1252 (2018) https://doi.org/10.1186/s12885-018-5175-y The Editors have retracted this article following an investigation report by the Ministry of Science and Technology of the People’s Republic of China. Their investigation found attempts to tamper with the data. The Editors therefore no longer have confidence in the integrity of the data in this article. Author, Hai
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Retraction Note: Curcumin inhibits proliferation, migration, invasion and promotes apoptosis of retinoblastoma cell lines through modulation of miR-99a and JAK/STAT pathway BMC Cancer (IF 3.8) Pub Date : 2024-04-15 Yaping Li, Weixuan Sun, Ning Han, Ying Zou, Dexin Yin
Retraction Note: BMC Cancer 18, 1230 (2018) https://doi.org/10.1186/s12885-018-5130-y The Editors have retracted this article following an investigation report by the Ministry of Science and Technology of the People’s Republic of China. Their investigation found attempts to tamper with the data. The Editors therefore no longer have confidence in the integrity of the data in this article. None of the
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Correction: Development and validation of a Radiopathomics model based on CT scans and whole slide images for discriminating between Stage I-II and Stage III gastric cancer BMC Cancer (IF 3.8) Pub Date : 2024-04-15 Yang Tan, Li-juan Feng, Ying-he Huang, Jia-wen Xue, Zhen-Bo Feng, Li-ling Long
Correction: BMC Cancer 24, 368 (2024) https://doi.org/10.1186/s12885-024-12021-2 Following publication of the original article [1], the authors noticed a typesetting error, whereby the equal contributions statement was erroneously omitted. The equal contributions statement should read: Yang Tan and Li-juan Feng have contributed equally to the study as co-first authors. The original article [1] has
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Relevance of blood tumor markers in inpatients with significant involuntary weight loss and elevated levels of inflammation biomarkers BMC Cancer (IF 3.8) Pub Date : 2024-04-15 Morgane Gronnier, Kaies Hedhli, Chloé Sauzay, Valéry Salle, Pierre Duhaut, Jean Schmidt, Amandine Dernoncourt
To assess the diagnostic performance of a panel of standard tumor markers (TMs) in patients hospitalized with significant involuntary weight loss (IWL) and elevated levels of inflammation biomarkers, and a combination of the TM panel and the finding of the computed tomography (CT) scan. We conducted a retrospective study in the internal medicine department at Amiens-Picardie University Medical Center
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Correlation between socioeconomic indices and epidemiological indices of thyroid cancer from 1990 to 2019 year: a global ecologic study BMC Cancer (IF 3.8) Pub Date : 2024-04-15 Zahra Maleki, Jafar Hassanzadeh, Haleh Ghaem
The incidence of thyroid cancer as the most common type of endocrine gland malignancy has risen more significantly than any malignancies in recent years. Estimated new cases of thyroid cancer in the United States in 2024 were 12,500 and 31,520 for men and women, respectively, and estimated deaths were 1,180 for women and 990 for men. Indices of socio-economic have been commonly used to measure the
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Prognostic value of pre-treatment [18F] FDG PET/CT in recurrent nasopharyngeal carcinoma without distant metastasis BMC Cancer (IF 3.8) Pub Date : 2024-04-15 Zhe Dong, Gao-Yuan Wang, Dong-Yu Dai, Guan-Jie Qin, Ling-Long Tang, Cheng Xu, Jun Ma
[18 F]-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) has the ability to detect local and/or regional recurrence as well as distant metastasis. We aimed to evaluate the prognosis value of PET/CT in locoregional recurrent nasopharyngeal (lrNPC). A total of 451 eligible patients diagnosed with recurrent I-IVA (rI-IVA) NPC between April 2009 and December 2015 were retrospectively
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Integrating trans-omics, cellular experiments and clinical validation to identify ILF2 as a diagnostic serum biomarker and therapeutic target in gastric cancer BMC Cancer (IF 3.8) Pub Date : 2024-04-15 Shao-Song Liu, Qin-Si Wan, Cong Lv, Jin-Ke Wang, Song Jiang, Dan Cai, Mao-Sheng Liu, Ting Wang, Kun-He Zhang
Gastric cancer (GC) lacks serum biomarkers with clinical diagnostic value. Multi-omics analysis is an important approach to discovering cancer biomarkers. This study aimed to identify and validate serum biomarkers for GC diagnosis by cross-analysis of proteomics and transcriptomics datasets. A cross-omics analysis was performed to identify overlapping differentially expressed genes (DEGs) between our
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The prognostic role of pre-treatment neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in esophageal squamous cell carcinoma treated with concurrent chemoradiotherapy BMC Cancer (IF 3.8) Pub Date : 2024-04-15 Qirong Man, Peishun Li, Jing Fan, Sen Yang, Chao Xing, Yunling Bai, Miaomiao Hu, Baohu wang, Kaixian Zhang
In this study, we retrospectively investigated the prognostic role of pre-treatment neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in esophageal squamous cell carcinoma patients (ESCC) treated with concurrent chemo-radiotherapy (CCRT). We retrospectively analyzed the records of 338 patients with pathologically diagnosed esophageal squamous cell carcinoma that underwent
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PSAT1 enhances the efficacy of the prognosis estimation nomogram model in stage-based clear cell renal cell carcinoma BMC Cancer (IF 3.8) Pub Date : 2024-04-13 Jun Wang, Xiaoming He, Yuanyuan Mi, Yong Q. Chen, Jie Li, Rong Wang
Clear cell renal cell carcinoma (ccRCC) is associated with a high prevalence of cancer-related deaths. The survival rates of patients are significantly lower in late-stage ccRCC than in early-stage ccRCC, due to the spread and metastasis of late-stage ccRCC, surgery has not reached the goal of radical cure, and the effect of traditional radiotherapy and chemotherapy is poor. Thus, it is crucial to
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Real-world evidence of treatment patterns and survival of metastatic gastric cancer patients in Germany BMC Cancer (IF 3.8) Pub Date : 2024-04-13 Jaime Luna, Nils Picker, Thomas Wilke, Magnus Lutz, Jürgen Hess, Bernhard Mörtl, Yan Xiong, Thorsten Oliver Götze
Patients with metastatic gastric cancer (mGC) have poor prognosis. This real-world study aimed to describe treatment regimens and survival of mGC patients. A retrospective analysis was conducted using anonymized German claims data (AOK PLUS) covering a period from 2010 to 2021. The study population included newly diagnosed mGC cases identified from 2011 to 2020. The index date was defined as the first
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Racial/ethnic differences in 21-gene recurrence score and survival among patients with estrogen receptor-positive breast cancer BMC Cancer (IF 3.8) Pub Date : 2024-04-13 Jasmin Gill, Keerti Yendamuri, Udit Chatterjee, Song Yao, Oluwadamilola T. Oladeru, Anurag K. Singh, Sung Jun Ma
Despite numerous studies on racial/ethnic disparities among patients with breast cancer, there is a paucity of literature evaluating racial/ethnic differences in 21-gene recurrence score (RS) and survival differences stratified by RS risk categories. We thus performed an observational cohort study to examine racial/ethnic disparities in the context of RS. The National Cancer Database (NCDB) was queried
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A combined nomogram based on radiomics and hematology to predict the pathological complete response of neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma BMC Cancer (IF 3.8) Pub Date : 2024-04-12 Yu Yang, Yan Yi, Zhongtang Wang, Shanshan Li, Bin Zhang, Zheng Sang, Lili Zhang, Qiang Cao, Baosheng Li
To predict pathological complete response (pCR) in patients receiving neoadjuvant immunochemotherapy (nICT) for esophageal squamous cell carcinoma (ESCC), we explored the factors that influence pCR after nICT and established a combined nomogram model. We retrospectively included 164 ESCC patients treated with nICT. The radiomics signature and hematology model were constructed utilizing least absolute
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Partial recovery of peripheral blood monocyte subsets in head and neck squamous cell carcinoma patients upon radio(chemo)therapy is associated with decreased plasma CXCL11 BMC Cancer (IF 3.8) Pub Date : 2024-04-12 Christian Idel, Jonas Fleckner, Kirstin Plötze-Martin, Lotte Werner, Dirk Rades, Marie-Nicole Theodoraki, Linda Hofmann, Diana Huber, Anke Leichtle, Thomas K. Hoffmann, Karl-Ludwig Bruchhage, Ralph Pries
Head and neck squamous cell carcinoma (HNSCC) represents a common and heterogeneous malignancy of the oral cavity, pharynx and larynx. Surgery and radio(chemo)therapy are the standard treatment options and also have great influence on the composition of the tumor microenvironment and immune cell functions. However, the impact of radio(chemo)therapy on the distribution and characteristics of circulating
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A chest CT-based nomogram for predicting survival in acute myeloid leukemia BMC Cancer (IF 3.8) Pub Date : 2024-04-12 Xiaoping Yi, Huien Zhan, Jun Lyu, Juan Du, Min Dai, Min Zhao, Yu Zhang, Cheng Zhou, Xin Xu, Yi Fan, Lin Li, Baoxia Dong, Xinya Jiang, Zeyu Xiao, Jihao Zhou, Minyi Zhao, Jian Zhang, Yan Fu, Tingting Chen, Yang Xu, Jie Tian, Qifa Liu, Hui Zeng
The identification of survival predictors is crucial for early intervention to improve outcome in acute myeloid leukemia (AML). This study aim to identify chest computed tomography (CT)-derived features to predict prognosis for acute myeloid leukemia (AML). 952 patients with pathologically-confirmed AML were retrospectively enrolled between 2010 and 2020. CT-derived features (including body composition
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Impact of the COVID-19 pandemic in childhood and adolescent cancer care in northern Tanzania: a cross-sectional study BMC Cancer (IF 3.8) Pub Date : 2024-04-12 Yotham Gwanika, Hannah E. Rice, Madeline Metcalf, Pamela Espinoza, Happiness D. Kajoka, Henry E. Rice, Catherine Staton, Blandina T. Mmbaga, Esther Majaliwa, Emily R. Smith, Cesia Cotache-Condor
The SARS-CoV-2 (COVID-19) pandemic has strained healthcare systems and presented unique challenges for children requiring cancer care, particularly in low- and middle-income countries. This study aimed to assess the impact of the COVID-19 pandemic on access to cancer care for children and adolescents in Northern Tanzania. In this cross-sectional study, we assessed the demographic and clinical characteristics
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The incidence of early onset colorectal cancer in Aotearoa New Zealand: 2000–2020 BMC Cancer (IF 3.8) Pub Date : 2024-04-12 Oliver Waddell, John Pearson, Andrew McCombie, Harriet Marshall, Rachel Purcell, Jacqueline Keenan, Tamara Glyn, Frank Frizelle
The incidence of early-onset colorectal cancer (EOCRC), diagnosed before age 50, has been rising in many countries in the past few decades. This study aims to evaluate this trend in Aotearoa New Zealand and assess its impact on Māori. Crude incidence and age-standardized incidence of colorectal cancer (CRC) was analyzed from all new cases from the Aotearoa New Zealand national cancer registry for the
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Biomarkers of lipid metabolism in gastric cancer: a case control study BMC Cancer (IF 3.8) Pub Date : 2024-04-11 Fangxuan Li, Jinli Dou, Lijuan Wei, Shixia Li, Juntian Liu
The aim of this study was to explore the correlation between biomarkers of lipid metabolism and gastric cancer. 1120 gastric cancer patients and 1134 health examiners enrolled in this study. The clinic data and serum lipid level, including Total cholesterol (TC), Triglyceride (TG), Low-density lipoprotein cholesterol (LDL-C) and High-density lipoprotein cholesterol (HDL-C), were collected. Serum TG
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The application of different machine learning models based on PET/CT images and EGFR in predicting brain metastasis of adenocarcinoma of the lung BMC Cancer (IF 3.8) Pub Date : 2024-04-11 Chao Kong, Xiaoyan Yin, Jingmin Zou, Changsheng Ma, Kai Liu
To explore the value of six machine learning models based on PET/CT radiomics combined with EGFR in predicting brain metastases of lung adenocarcinoma. Retrospectively collected 204 patients with lung adenocarcinoma who underwent PET/CT examination and EGFR gene detection before treatment from Cancer Hospital Affiliated to Shandong First Medical University in 2020. Using univariate analysis and multivariate
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Exploring the relationship between Treg-mediated risk in COPD and lung cancer through Mendelian randomization analysis and scRNA-seq data integration BMC Cancer (IF 3.8) Pub Date : 2024-04-11 Dengfeng Zhang, Haitao Liu, Fangchao Zhao, Pengfei Guo, Jing Li, Tianxing Lu, Zhirong Li, Shujun Li
Evidence from observational studies suggests an association between chronic obstructive pulmonary disease (COPD) and lung cancer. The potential interactions between the immune system and the lungs may play a causative role in COPD and lung cancer and offer therapeutic prospects. However, the causal association and the immune-mediated mechanisms between COPD and lung cancer remain to be determined.
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ESCO2’s oncogenic role in human tumors: a pan-cancer analysis and experimental validation BMC Cancer (IF 3.8) Pub Date : 2024-04-11 Yue Huang, Dapeng Chen, Yi Bai, Yamin Zhang, Zhiwen Zheng, Qingfeng Fu, Bocun Yi, Yuchen Jiang, Zhihong Zhang, Jianqiang Zhu
Establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2) is involved in the mitotic S-phase adhesins acetylation and is responsible for bridging two sister chromatids. However, present ESCO2 cancer research is limited to a few cancers. No systematic pan-cancer analysis has been conducted to investigate its role in diagnosis, prognosis, and effector function. We thoroughly examined the
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Cellular senescence and metabolic reprogramming model based on bulk/single-cell RNA sequencing reveals PTGER4 as a therapeutic target for ccRCC BMC Cancer (IF 3.8) Pub Date : 2024-04-11 Lijie Zhou, Youmiao Zeng, Yuanhao Liu, Kaixuan Du, Yongbo Luo, Yiheng Dai, Wenbang Pan, Lailai Zhang, Lei Zhang, Fengyan Tian, Chaohui Gu
Clear cell renal cell carcinoma (ccRCC) is the prevailing histological subtype of renal cell carcinoma and has unique metabolic reprogramming during its occurrence and development. Cell senescence is one of the newly identified tumor characteristics. However, there is a dearth of methodical and all-encompassing investigations regarding the correlation between the broad-ranging alterations in metabolic
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Baseline knowledge on risk factors, symptoms and intended behavior of women and men towards screening and treatment of cervical cancer in rural Uganda: a cross-sectional study BMC Cancer (IF 3.8) Pub Date : 2024-04-11 Carolyn Nakisige, Marlieke de Fouw, Miriam Nakalembe, Jackson Orem, Dan Atukonyera, Mwalimu Musheshe, Jaap Koot, Janine de Zeeuw, Jogchum Beltman, Jelle Stekelenburg
Knowledge of risk factors and symptoms of cervical cancer has been found to promote uptake of screening of cervical cancer. Most interventions targeted women without much involvement of men (husbands/decision makers) who are often decision makers in many low- and middle-income countries. This study aimed at assessing baseline knowledge and intended behavior of both women and men to enable design specific
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Plasma extracellular vesicles in meningioma patients following radiotherapy as liquid biopsy- a prospective explorative biomarker study (ARO 2023-05/AG-NRO-07) BMC Cancer (IF 3.8) Pub Date : 2024-04-11 Maximilian Y. Deng, Amanda Salviano da Silva, Pauline Carlotta Göller, Laila König, Henning Schäfer, Cecile Maire, Adriane Lentz-Hommertgen, Thomas Held, Sebastian Regnery, Tanja Eichkorn, Florian Stritzke, Lukas Bauer, Daniel Schnell, Klaus Herfarth, Andreas von Deimling, Sandro Krieg, Antje Wick, Wolfgang Wick, Anca Grosu, Jürgen Debus, Felix Sahm, Franz Ricklefs
While surgical resection remains the primary treatment approach for symptomatic or growing meningiomas, radiotherapy represents an auspicious alternative in patients with meningiomas not safely amenable to surgery. Biopsies are often omitted in light of potential postoperative neurological deficits, resulting in a lack of histological grading and (molecular) risk stratification. In this prospective
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Advantage of whole-mount histopathology in prostate cancer: current applications and future prospects BMC Cancer (IF 3.8) Pub Date : 2024-04-11 Lewei Duan, Zheng Liu, Fangning Wan, Bo Dai
Whole-mount histopathology (WMH) has been a powerful tool to investigate the characteristics of prostate cancer. However, the latest advancement of WMH was yet under summarization. In this review, we offer a comprehensive exposition of current research utilizing WMH in diagnosing and treating prostate cancer (PCa), and summarize the clinical advantages of WMH and outlines potential on future prospects
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Do beta-blockers reduce negative intrusive thoughts and anxiety in cancer survivors? – An emulated trial BMC Cancer (IF 3.8) Pub Date : 2024-04-11 Carolina Ehrencrona, Ying Li, Eva Angenete, Eva Haglind, Stefan Franzén, Anna Grimby-Ekman, David Bock
High rates of negative intrusive thoughts have been reported among cancer patients. Prevalent users of beta-blocker therapy have reported lower levels of cancer related intrusive thoughts than non-user. The aim of this study is to investigate if initiation of beta-blocker therapy reduces the prevalence and severity of intrusive thoughts (co-primary endpoints) and the prevalence of anxiety, depressed
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Binimetinib in combination with nivolumab or nivolumab and ipilimumab in patients with previously treated microsatellite-stable metastatic colorectal cancer with RAS mutations in an open-label phase 1b/2 study BMC Cancer (IF 3.8) Pub Date : 2024-04-11 Elena Elez, Antonio Cubillo, Pilar Garcia Alfonso, Mark R. Middleton, Ian Chau, Baha Alkuzweny, Ann Alcasid, Xiaosong Zhang, Eric Van Cutsem
In patients with previously treated RAS-mutated microsatellite-stable (MSS) metastatic colorectal cancer (mCRC), a multicenter open-label phase 1b/2 trial was conducted to define the safety and efficacy of the MEK1/MEK2 inhibitor binimetinib in combination with the immune checkpoint inhibitor (ICI) nivolumab (anti–PD-1) or nivolumab and another ICI, ipilimumab (anti-CTLA4). In phase 1b, participants
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Targeting PCSK9 to upregulate MHC-II on the surface of tumor cells in tumor immunotherapy BMC Cancer (IF 3.8) Pub Date : 2024-04-10 Hanbing Wang, Xin Zhang, Yipeng Zhang, Tao Shi, Yue Zhang, Xueru Song, Baorui Liu, Yue Wang, Jia Wei
Proprotein convertase subtilisin/kexin type 9 (PCSK9), the last member of the proprotein convertase family, functions as a classic regulator of low-density lipoprotein (LDL) by interacting with low-density lipoprotein receptor (LDLR). Recent studies have shown that PCSK9 can affect the occurrence and development of tumors and can be used as a novel therapeutic target. However, a comprehensive pan-cancer
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First-in-human study of GFH018, a small molecule inhibitor of transforming growth factor-β receptor I inhibitor, in patients with advanced solid tumors BMC Cancer (IF 3.8) Pub Date : 2024-04-10 Ye Guo, Zishu Wang, Huan Zhou, Hongming Pan, Weidong Han, Yanhong Deng, Qun Li, Junli Xue, Xiaoxiao Ge, Shuang Wang, Jing Wang, Yue Zhang, Congqiao Zhao, Huaqiang Zhu, Yu Wang, Haige Shen, Dong Liu, Jin Li
Transforming growth factor-β (TGF-β) is a cytokine with multiple functions, including cell growth regulation, extracellular matrix production, angiogenesis homeostasis adjustment and et al. TGF-β pathway activation promotes tumor metastasis/progression and mediates epithelial-mesenchymal transmission suppressing immunosurveillance in advanced tumors. GFH018, a small molecule inhibitor blocking TGF-β
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Identification of stemness-related glycosylation changes in head and neck squamous cell carcinoma BMC Cancer (IF 3.8) Pub Date : 2024-04-10 E Routila, R Mahran, S Salminen, H Irjala, E Haapio, E Kytö, S Ventelä, K Petterson, J Routila, K Gidwani, J Leivo
Altered glycosylation is a hallmark of cancer associated with therapy resistance and tumor behavior. In this study, we investigated the glycosylation profile of stemness-related proteins OCT4, CIP2A, MET, and LIMA1 in HNSCC tumors. Tumor, adjacent normal tissue, and blood samples of 25 patients were collected together with clinical details. After tissue processing, lectin-based glycovariant screens
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Biplex quantitative PCR to detect transcriptionally active human papillomavirus 16 from patient saliva BMC Cancer (IF 3.8) Pub Date : 2024-04-10 Fiona Deutsch, Dayna Sais, Ni Keatinge, Meredith Hill, Ngoc Ha Tran, Michael Elliott, Nham Tran
Head and neck cancers, particularly oropharyngeal cancers (OPC), have been increasingly associated with human papillomavirus (HPV) infections, specifically HPV16. The current methods for HPV16 detection primarily rely on p16 staining or PCR techniques. However, it is important to note the limitations of conventional PCR, as the presence of viral DNA does not always indicate an ongoing viral infection
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Elucidating the role of EPPK1 in lung adenocarcinoma development BMC Cancer (IF 3.8) Pub Date : 2024-04-10 Ken Arimura, Michael Kammer, S. M. Jamshedur Rahman, Chen Sheau-Chiann, Shilin Zhao, Chen Heidi, Rosana Eisenberg, Yong Zou, Sanja Antic, Bradley Richmond, Etsuko Tagaya, Eric Grogan, Pierre Massion, Fabien Maldonado
We recently found that epiplakin 1 (EPPK1) alterations were present in 12% of lung adenocarcinoma (LUAD) cases and were associated with a poor prognosis in early-stage LUAD when combined with other molecular alterations. This study aimed to identify a probable crucial role for EPPK1 in cancer development. EPPK1 mRNA and protein expression was analyzed with clinical variables. Normal bronchial epithelial
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Long-term survival after neoadjuvant therapy for triple-negative breast cancer under different treatment regimens: a systematic review and network meta-analysis BMC Cancer (IF 3.8) Pub Date : 2024-04-09 Zhilin Liu, Jinming Li, Fuxing Zhao, Dengfeng Ren, Zitao Li, Yongzhi Chen, Shifen Huang, Zhen Liu, Yi Zhao, Miaozhou Wang, Huihui Li, ZhengBo Xu, Guoshuang Shen, Jiuda Zhao
Triple-negative breast cancer (TNBC) is a life-threatening subtype of breast cancer with limited treatment options. Therefore, this network meta-analysis (NMA) aimed to evaluate and compare the effect of various neoadjuvant chemotherapy (NCT) options on the long-term survival of patients with TNBC. PubMed, Embase, Medline, Cochrane Library, Web of Science, and major international conference databases
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Interaction of immune cells with renal cancer development: Mendelian randomization (MR) study BMC Cancer (IF 3.8) Pub Date : 2024-04-09 Zhongwen Lu, Yu Yin, Tian Rao, Xinchi Xu, Kai Zhao, Zhanpeng Liu, Chao Qin, Min Tang
Renal cell carcinoma (RCC) is a prevalent and extensively immune-infiltrated malignancy of the urinary system. Immune cells play a crucial role in both the progression and therapeutic interventions targeting RCC. Nevertheless, the interplay between RCC and immune cells remains understudied, lacking substantial evidence supporting their causal relationship. For the purpose of investigating the causal
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A nomogram based on the quantitative and qualitative features of CT imaging for the prediction of the invasiveness of ground glass nodules in lung adenocarcinoma BMC Cancer (IF 3.8) Pub Date : 2024-04-09 Yantao Yang, Jing Xu, Wei Wang, Mingsheng Ma, Qiubo Huang, Chen Zhou, Jie Zhao, Yaowu Duan, Jia Luo, Jiezhi Jiang, Lianhua Ye
Based on the quantitative and qualitative features of CT imaging, a model for predicting the invasiveness of ground-glass nodules (GGNs) was constructed, which could provide a reference value for preoperative planning of GGN patients. Altogether, 702 patients with GGNs (including 748 GGNs) were included in this study. The GGNs operated between September 2020 and July 2022 were classified into the training
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Habitat escalated adaptive therapy (HEAT): a phase 2 trial utilizing radiomic habitat-directed and genomic-adjusted radiation dose (GARD) optimization for high-grade soft tissue sarcoma BMC Cancer (IF 3.8) Pub Date : 2024-04-09 Arash O. Naghavi, J. M. Bryant, Youngchul Kim, Joseph Weygand, Gage Redler, Austin J. Sim, Justin Miller, Kaitlyn Coucoules, Lauren Taylor Michael, Warren E. Gloria, George Yang, Stephen A. Rosenberg, Kamran Ahmed, Marilyn M. Bui, Evita B. Henderson-Jackson, Andrew Lee, Caitlin D. Lee, Ricardo J. Gonzalez, Vladimir Feygelman, Steven A. Eschrich, Jacob G. Scott, Javier Torres-Roca, Kujtim Latifi, Nainesh
Soft tissue sarcomas (STS), have significant inter- and intra-tumoral heterogeneity, with poor response to standard neoadjuvant radiotherapy (RT). Achieving a favorable pathologic response (FPR ≥ 95%) from RT is associated with improved patient outcome. Genomic adjusted radiation dose (GARD), a radiation-specific metric that quantifies the expected RT treatment effect as a function of tumor dose and
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A phase II/III randomized clinical trial of CisPlatin plUs Gemcitabine and Nabpaclitaxel (GAP) as pReoperative chemotherapy versus immediate resection in patIents with resecTable BiliarY Tract Cancers (BTC) at high risk for recurrence: PURITY study BMC Cancer (IF 3.8) Pub Date : 2024-04-08 Monica Niger, Federico Nichetti, Lorenzo Fornaro, Chiara Pircher, Federica Morano, Federica Palermo, Lorenza Rimassa, Tiziana Pressiani, Rossana Berardi, Andrea Casadei Gardini, Elisa Sperti, Lisa Salvatore, Davide Melisi, Francesca Bergamo, Salvatore Siena, Stefania Mosconi, Raffaella Longarini, Giuseppina Arcangeli, Salvatore Corallo, Laura Delliponti, Stefano Tamberi, Elena Fea, Giovanni Brandi
Biliary tract cancers (BTCs) are rare and lethal cancers, with a 5-year survival inferior to 20%(1–3). The only potential curative treatment is surgical resection. However, despite complex surgical procedures that have a remarkable risk of postoperative morbidity and mortality, the 5-year survival rate after radical surgery (R0) is 20–40% and recurrence rates are up to ~ 75%(4–6). Up to ~ 40% of patients