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α‑Phellandrene enhances the apoptosis of HT‑29 cells induced by 5‑fluorouracil by modulating the mitochondria‑dependent pathway. Oncol. Rep. (IF 4.2) Pub Date : 2024-03-08 Anita Caroline Susanto, Laksmi Hartajanie, Chih-Chung Wu
α‑Phellandrene (α‑PA), a natural constituent of herbs, inhibits cancer cell viability and proliferation. 5‑Fluorouracil (5‑FU) is a frequently utilized chemotherapeutic medicine for the treatment of colon cancer, which works by triggering cancer cell apoptosis. The present study examined how the combination of α‑PA and 5‑FU affects the suppression of human colon cancer cells by promoting apoptosis
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MITF regulates the subcellular location of HIF1α through SUMOylation to promote the invasion and metastasis of daughter cells derived from polyploid giant cancer cells. Oncol. Rep. (IF 4.2) Pub Date : 2024-03-08 Minying Zheng, Shifeng Tian, Xinyue Zhou, Man Yan, Mingming Zhou, Yongjun Yu, Yue Zhang, Xiaorui Wang, Na Li, Li Ren, Shiwu Zhang
High concentrations of cobalt chloride (CoCl2) can induce the formation of polyploid giant cancer cells (PGCCs) in various tumors, which can produce daughter cells with strong proliferative, migratory and invasive abilities via asymmetric division. To study the role of hypoxia‑inducible factor (HIF) 1α in the formation of PGCCs, colon cancer cell lines Hct116 and LoVo were used as experimental subjects
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[Retracted] MicroRNA‑140 represses glioma growth and metastasis by directly targeting ADAM9. Oncol. Rep. (IF 4.2) Pub Date : 2024-03-08 Xiaogang Liu, Shanjun Wang, Aiqin Yuan, Xunhui Yuan, Bing Liu
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that certain of the Transwell cell invasion and migration assay data shown in Figs. 2C and 5D were strikingly similar to data in different form in other articles written by different authors at different research institutes, which had either already been published or had been submitted for publication
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[Corrigendum] Induction of microRNA‑let‑7a inhibits lung adeno-carcinoma cell growth by regulating cyclin D1. Oncol. Rep. (IF 4.2) Pub Date : 2024-03-08 Wei Zhao, Jin-Xia Hu, Rui-Min Hao, Qian Zhang, Jun-Qi Guo, You-Jie Li, Ning Xie, Lu-Ying Liu, Ping-Yu Wang, Can Zhang, Shu-Yang Xie
After the publication of the article, an interested reader drew to the authors' attention that, in the western blots shown in Fig. 5C and D, a pair of data panels were inadvertently duplicated comparing between panels (C) and (D); in addition, the cell migration data shown in Fig. 7F on p. 1852 were selected incorrectly. The authors have examined their original data, and realize that these errors arose
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Current and future perspectives in unresectable locally advanced esophageal squamous cell cancer (Review). Oncol. Rep. (IF 4.2) Pub Date : 2024-03-08 Weijia Zhang, Min Zhu, Ying Xiang, Yujiao Sun, Shuang Li, Jun Cai, Hai Zeng
Definitive concurrent chemoradiotherapy has been the main standard treatment method for unresectable locally advanced esophageal squamous cell cancer (ESCC) since 1999. However, several disadvantages continue to be associated with this type of treatment, including a high local failure rate (reaching ~50% within 3 years) and a median overall survival (OS) time of 16.9 months. In addition, the 5‑year
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Unveiling the best predictive models for early‑onset metastatic cancer: Insights and innovations (Review). Oncol. Rep. (IF 4.2) Pub Date : 2024-03-08 Liqing Yu, Zhenjun Huang, Ziqi Xiao, Xiaofu Tang, Ziqiang Zeng, Xiaoli Tang, Wenhao Ouyang
Cancer metastasis is the primary cause of cancer deaths. Metastasis involves the spread of cancer cells from the primary tumors to other body parts, commonly through lymphatic and vascular pathways. Key aspects include the high mutation rate and the capability of metastatic cells to form invasive tumors even without a large initial tumor mass. Particular emphasis is given to early metastasis, occurring
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m6A methyltransferase METTL14‑mediated RP1‑228H13.5 promotes the occurrence of liver cancer by targeting hsa‑miR‑205/ZIK1. Oncol. Rep. (IF 4.2) Pub Date : 2024-03-01 Jia Xu, Chang Liu, Kai Qu, Jingyao Zhang, Sinan Liu, Fandi Meng, Yong Wan
The aim of the present study was to explore the association between N6‑methyladenosine (m6A) modification regulatory gene‑related long noncoding (lnc)RNA RP1‑228H13.5 and cancer prognosis through bioinformatics analysis, as well as the impact of RP1‑228H13.5 on cell biology‑related behaviors and specific molecular mechanisms. Bioinformatics analysis was used to construct a risk model consisting of
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[Retracted] Downregulation of microRNA-206 suppresses clear cell renal carcinoma proliferation and invasion by targeting vascular endothelial growth factor A. Oncol. Rep. (IF 4.2) Pub Date : 2024-03-01 Yi Cai, Hanzhong Li, Yushi Zhang
Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that there appeared to be several instances of overlapping data panels comparing between the Transwell invasion and migration assay images shown in Figs. 2E and 4G, such that data which were intended to show the results from differently performed experiments were apparently derived from a (much)
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[Retracted] MicroRNA‑362 is downregulated in cervical cancer and inhibits cell proliferation, migration and invasion by directly targeting SIX1. Oncol. Rep. (IF 4.2) Pub Date : 2024-02-09 Can Shi, Zhenyu Zhang
Following the publication of the above article, a concerned reader drew to the Editor's attention that the Transwell cell migration and invasion assay data featured in Fig. 2C were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published elsewhere prior to the submission of this paper
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Advances in research and application of photodynamic therapy in cholangiocarcinoma (Review). Oncol. Rep. (IF 4.2) Pub Date : 2024-02-09 Yufeng Li, Yuhang Li, Yinghui Song, Sulai Liu
Cholangiocarcinoma (CCA) is a disease characterized by insidious clinical manifestations and challenging to diagnose. Patients are usually diagnosed at an advanced stage and miss the opportunity for radical surgery. Therefore, effective palliative therapy is the main treatment approach for unresectable CCA. Current common palliative treatments include biliary drainage, chemotherapy, radiotherapy, targeted
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Evaluation of DNA methylation levels of SEPT9 and SHOX2 in plasma of patients with head and neck squamous cell carcinoma using droplet digital PCR. Oncol. Rep. (IF 4.2) Pub Date : 2024-02-01 Ilaria Grossi, Claudia Assoni, Luigi Lorini, Davide Smussi, Cristina Gurizzan, Salvatore Grisanti, Alberto Paderno, Davide Mattavelli, Cesare Piazza, Iulia Andreea Pelisenco, Giuseppina De Petro, Alessandro Salvi, Paolo Bossi
Head and neck squamous cell carcinoma (HNSCC) is the seventh most commonly diagnosed cancer globally. HNSCC develops from the mucosa of the oral cavity, pharynx and larynx. Methylation levels of septin 9 (SEPT9) and short stature homeobox 2 (SHOX2) genes in circulating cell‑free DNA (ccfDNA) are considered epigenetic biomarkers and have shown predictive value in preliminary reports in HNSCC. Liquid
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Enhancing the therapeutic efficacy of NK cells in the treatment of ovarian cancer (Review). Oncol. Rep. (IF 4.2) Pub Date : 2024-02-01 Yuzhu Hou, Xiujun Zhao, Xiaoqian Nie
Ovarian cancer is a prevalent gynecological malignancy associated with a high mortality rate and a low 5‑year survival rate. Typically, >70% of patients present with an advanced stage of the disease, resulting in a high number of ovarian cancer‑associated deaths worldwide. Over the past decade, adoptive cellular immunotherapy has been investigated in clinical trials, and the results have led to the
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[Retracted] miR‑17‑5p promotes the growth of osteosarcoma in a BRCC2‑dependent mechanism. Oncol. Rep. (IF 4.2) Pub Date : 2024-02-01 Wei Wang, Liang Zhang, Ke Zheng, Xiaojing Zhang
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the western blotting data shown in Fig. 7 on p. 1480 were strikingly similar to data that had already been published in another article written by different authors at different research institutes, which has subsequently been retracted [Fan C, Wang Y, Liu Z, Sun Y, Wang X, Wei G and Wei J: Metformin
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The phenotypic reversion of cancer: Experimental evidences on cancer reversibility through epigenetic mechanisms (Review). Oncol. Rep. (IF 4.2) Pub Date : 2024-01-26 Andrea Pensotti, Mariano Bizzarri, Marta Bertolaso
Different experimental models reveal that malignant cancer cells can be induced to change their phenotype into a benign one. This phenotypic transformation, confirmed both in vitro and in vivo, currently is known as 'tumor reversion'. This evidence raises a radical question among current cancer models: Is cancer reversible? How do genetic and epigenetic alterations hierarchically relate? Understanding
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[Corrigendum] Azurocidin 1 inhibits the aberrant proliferation of triple‑negative breast cancer through the regulation of pyroptosis. Oncol. Rep. (IF 4.2) Pub Date : 2024-01-26 Shanshan Lei, Shutong Li, Weiwei Xiao, Qiuping Jiang, Shifan Yan, Wen Xiao, Jiaodi Cai, Jingjing Wang, Lianhong Zou, Fang Chen, Yanjuan Liu, Yu Jiang
Following the publication of the above article, the authors drew to our attention that they had made a couple of inadvertent errors in assembling Figs. 4 and 5; first, for the BT‑549 cell line, the data shown for the Pro‑caspase‑1/Cleaved caspase‑1 in Fig. 5 and the GSDMD‑F/GSDMD‑N data in Fig. 4B were identical, and had been derived from the same original source; secondly, in Fig. 4A, the data shown
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[Retracted] MicroRNA‑520a attenuates proliferation of Raji cells through inhibition of AKT1/NF‑κB and PERK/eIF2α signaling pathway. Oncol. Rep. (IF 4.2) Pub Date : 2024-01-26 Xiaojuan Wang, Pei Wang, Yan Zhu, Zhi Zhang, Jinqian Zhang, Hongwei Wang
Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that a pair of the lanes featured in the western blot gel for Fig. 3B on p. 1705 were strikingly similar, suggesting that the same data may have been imported into the figure to represent data that were intended to show the results from differently performed experiments. In addition, the western data
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Bone marrow stromal cell antigen 2: Tumor biology, signaling pathway and therapeutic targeting (Review). Oncol. Rep. (IF 4.2) Pub Date : 2024-01-19 Honglian Yu, Qiang Bian, Xin Wang, Xinzhe Wang, Luhao Lai, Zhichun Wu, Zhankui Zhao, Bo Ban
Bone marrow stromal cell antigen 2 (BST2) is a type II transmembrane protein that serves critical roles in antiretroviral defense in the innate immune response. In addition, it has been suggested that BST2 is highly expressed in various types of human cancer and high BST2 expression is related to different clinicopathological parameters in cancer. The molecular mechanism underlying BST2 as a potential
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Advances in artificial intelligence for the diagnosis and treatment of ovarian cancer (Review). Oncol. Rep. (IF 4.2) Pub Date : 2024-01-19 Yanli Wang, Weihong Lin, Xiaoling Zhuang, Xiali Wang, Yifang He, Luhong Li, Guorong Lyu
Artificial intelligence (AI) has emerged as a crucial technique for extracting high‑throughput information from various sources, including medical images, pathological images, and genomics, transcriptomics, proteomics and metabolomics data. AI has been widely used in the field of diagnosis, for the differentiation of benign and malignant ovarian cancer (OC), and for prognostic assessment, with favorable
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[Retracted] Effect of RhoC on the epithelial‑mesenchymal transition process induced by TGF‑β1 in lung adenocarcinoma cells. Oncol. Rep. (IF 4.2) Pub Date : 2024-01-19 Xiaoxiao Lu, Honglan Guo, Xi Chen, Jian Xiao, Yong Zou, Wei Wang, Qiong Chen
Following the publication of the above article, a concerned reader drew to the Editor's attention that the Transwell cell invasion assay data featured in Figs. 3 and 5, and the cell microscopic/morphological images shown in Fig. 4A and C, were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already
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[Corrigendum] PRIMA‑1met induces autophagy in colorectal cancer cells through upregulation of the mTOR/AMPK‑ULK1‑Vps34 signaling cascade. Oncol. Rep. (IF 4.2) Pub Date : 2024-01-19 Xiao-Lan Li, Jianbiao Zhou, Chen-Jing Xia, Han Min, Zhong-Kai Lu, Zhi-Rong Chen
Following the publication of the above article, the authors contacted the Editorial Office to explain that the strips of β‑actin, LC3 and p62 proteins of the RKO cell line shown in Fig. 2A and B, and those of the SW620 cell line shown in Fig. 3A and B, were assembled in these figures incorrectly. To rectify the presentation of these two figures, the authors proposed that they replace the strips of
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Aberrant trophoblastic differentiation in human cancer: An emerging novel therapeutic target (Review). Oncol. Rep. (IF 4.2) Pub Date : 2024-01-19 Chen Chang, Yi-Lin Chen, Yi-Wen Wang, Hui-Wen Chen, Che-Wei Hsu, Kun-Che Lin, Yin-Chien Ou, Tsunglin Liu, Wan-Li Chen, Chien-An Chu, Chung-Liang Ho, Chung-Ta Lee, Nan-Haw Chow
Various types of human cancer may develop aberrant trophoblastic differentiation, including histological changes and altered expression of β‑human chorionic gonadotropin (β‑hCG). Aberrant trophoblastic differentiation in epithelial cancer is usually associated with poor differentiation, tumor metastasis, unfavorable prognosis and treatment resistance. Since β‑hCG‑targeting vaccines have failed in an
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Epigenetic regulation of mRNA mediates the phenotypic plasticity of cancer cells during metastasis and therapeutic resistance (Review). Oncol. Rep. (IF 4.2) Pub Date : 2023-12-22 Chunzhi Zhang, Siyuan Liang, Hanning Zhang, Ruoxi Wang, Huanhuan Qiao
Plasticity, the ability of cancer cells to transition between differentiation states without genomic alterations, has been recognized as a major source of intratumoral heterogeneity. It has a crucial role in cancer metastasis and treatment resistance. Thus, targeting plasticity holds tremendous promise. However, the molecular mechanisms of plasticity in cancer cells remain poorly understood. Several
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A novel treatment to enhance survival for end stage triple negative breast cancer using repurposed veterinary anthelmintics combined with gut‑supporting/immune enhancing molecules. Oncol. Rep. (IF 4.2) Pub Date : 2023-12-22 Vijaya Iragavarapu-Charyulu, Rojesh Shakya, Philip Robinson, Esther Guzmán, Anastasia Tyulmenkova, Jose Labrador Pino, Ceylan Isgor
Patients with end‑stage metastatic disease have limited treatment options and those diagnosed with triple negative breast cancer (Her2, Estrogen receptor, Progesterone receptor) have a poor prognosis. Using a triple negative mammary tumor model selected for brain metastasis (4T1Br4) in the mouse, treatment options that may increase survival when therapeutics are applied at post‑metastasis were assessed
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Rab25 suppresses colon cancer cell invasion through upregulating claudin‑7 expression. Oncol. Rep. (IF 4.2) Pub Date : 2023-12-22 Su Jin Cho, Bo Young Jeong, Se-Hee Yoon, Chang Gyo Park, Hoi Young Lee
Ras‑related protein 25 (Rab25) is a member of small GTPase and is implicated in cancer cell progression of various types of cancer. Growing evidence suggests the context‑dependent role of Rab25 in cancer invasiveness. Claudin‑7 is a tight junction protein and has been known to suppress cancer cell invasion. Although Rab25 was reported to repress cancer aggressiveness through recycling β1 integrin to
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Identification of ITGB4 as a novel tumor promoting gene in lung adenocarcinoma (LUAD). Oncol. Rep. (IF 4.2) Pub Date : 2023-12-22 Xuan Lu, Sai Ma, Ying Li, Yunzhi Pan, Ningning Kang
As the most frequently diagnosed cancer, lung cancer (LC) is the most common cause of cancer‑related death worldwide. In total, ~85% of malignant lung tumors belong to non‑small cell LC, of which ~50% are lung adenocarcinoma (LUAD). Integrin subunit β4 (ITGB4) is upregulated in lung glandular cancer and elevated ITGB4 levels predict an adverse clinical outcome. However, the biological function of ITGB4
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[Retracted] Isoquercitrin inhibits bladder cancer progression in vitro and in vivo by regulating the PI3K/Akt and PKC signaling pathways. Oncol. Rep. (IF 4.2) Pub Date : 2023-12-22 Feng Chen, Xiaochi Chen, Deyong Yang, Xiangyu Che, Jianbo Wang, Xiancheng Li, Zhiwei Zhang, Qifei Wang, Wei Zheng, Lina Wang, Xuejian Wang, Xishuang Song
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the agarose gel electrophoretic bands shown in Fig. 4A for PKC were strikingly similar to bands that had already appeared in another article written by different authors at different research institutes. Owing to the fact that the contentious data in the above article had already been published
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Activin A induces apoptosis of human lung adenocarcinoma A549 cells through endoplasmic reticulum stress pathway. Oncol. Rep. (IF 4.2) Pub Date : 2023-12-22 Fenglin Zhang, Yan Qi, Jing Li, Boyang Liu, Zhonghui Liu, Xueling Cui
Activin A, a member of the transforming growth factor‑β (TGF‑β) superfamily, has been implicated in the tumorigenesis and progression of various cancers. However, it remains unclear whether activin A induces apoptosis in human lung adenocarcinoma cells through the endoplasmic reticulum (ER) stress pathway. In the present study, BrdU, flow cytometry and western blotting were used to examine cell proliferation
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Ursolic acid inhibits the metastasis of colon cancer by downregulating ARL4C expression. Oncol. Rep. (IF 4.2) Pub Date : 2023-12-22 Mengzhe Zhang, Fenfen Xiang, Yipeng Sun, Rongrong Liu, Qian Li, Qing Gu, Xiangdong Kang, Rong Wu
Ursolic acid (UA), a natural pentacyclic triterpenoid, is known to exhibit various biological activities and anticancer effects. However, the underlying anticancer mechanism is not fully understood to date. The present study aimed to investigate the antimetastatic effect of UA through ADP‑ribosylation factor like GTPase 4C (ARL4C) in colon cancer. A lung metastasis model of colon cancer in nude mice
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Exosomal circRNAs in gastrointestinal cancer: Role in occurrence, development, diagnosis and clinical application (Review). Oncol. Rep. (IF 4.2) Pub Date : 2023-12-15 Yumeng Xu, Jiayi Han, Xuan Zhang, Xinyi Zhang, Jiajia Song, Zihan Gao, Hui Qian, Jianhua Jin, Zhaofeng Liang
Gastrointestinal cancer is frequently detected at an advanced stage and has an undesirable prognosis due to the absence of efficient and precise biomarkers and therapeutic targets. Exosomes are small, living‑cell‑derived vesicles that serve a critical role in facilitating intercellular communication by transporting molecules from donor cells to receiver cells. circular RNAs (circRNAs) are mis‑expressed
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Inhibitor of Wnt receptor 1 suppresses the effects of Wnt1, Wnt3a and β‑catenin on the proliferation and migration of C6 GSCs induced by low‑dose radiation. Oncol. Rep. (IF 4.2) Pub Date : 2023-12-15 Yu Yan, Ying-Ying Cheng, Yan-Ru Li, Xu-Wen Jiao, Yin-Ming Liu, Hai-Yan Cai, Yin-Xiu Ding
The radioresistance of glioma is an important cause of treatment failure and tumor aggressiveness. In the present study, under performed with linear accelerator, the effects of 0.3 and 3.0 Gy low‑dose radiation (LDR) on the proliferation and migration of C6 glioma stem cells in vitro were examined by flow cytometric analysis, immunocytochemistry and western blot analysis. It was found that low‑dose
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G protein‑mediated EGFR transactivation is a common mechanism through which the CXCL12 receptors, CXCR4 and CXCR7, control human cancer cell migration. Oncol. Rep. (IF 4.2) Pub Date : 2023-12-15 Konstanze Zieger-Naumann, Frederike Kuhl, Jürgen Engele
C‑X‑C motif chemokine 12 (CXCL12) promotes metastasis of several tumors by affecting cell migration and invasion via its receptors, C‑X‑C chemokine receptor type (CXCR)4 and CXCR7. Current therapeutic approaches focus on the selective inactivation of either CXCR4 or CXCR7 in patients with cancer. Alternative strategies may emerge from the analysis of downstream events that mediate the migratory effects
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[Retracted] miR‑141 inhibits prostatic cancer cell proliferation and migration, and induces cell apoptosis via targeting of RUNX1. Oncol. Rep. (IF 4.2) Pub Date : 2023-12-15 Song Xu, Jingping Ge, Zhengyu Zhang, Wenquan Zhou
Following the publication of the above paper, a concerned reader drew to the Editor's attention that a number of plates showing colony formation assay data in Fig. 3A appeared to be overlapping, such that data purportedly showing the results from differently performed experiments may have been derived from the same original source(s); furthermore, certain of the cell‑cycle histograms shown in Fig. 4B
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Caffeic acid phenethyl ester: Unveiling its potential as a potent apoptosis inducer for combating hypopharyngeal squamous cell carcinoma. Oncol. Rep. (IF 4.2) Pub Date : 2023-12-15 Hyun-Ji Kim, Min-Hye Ahn, Ji-Ae Shin, Su-Jung Choi, Hyun-Ju Yu, Sung-Dae Cho
Hypopharyngeal squamous cell carcinoma (HSCC) is a relatively rare form of head and neck cancer that is notorious for its poor prognosis and low overall survival rate. This highlights the need for new therapeutic options for this malignancy. The objective of the present study was to examine the ability of caffeic acid phenethyl ester (CAPE), which is an active compound found in propolis, to combat
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STING promotes invasion and migration of uveal melanoma through p38‑MAPK signaling. Oncol. Rep. (IF 4.2) Pub Date : 2023-12-15 Xiaoting Zhou, Fengxi Meng, Binbin Xu, Ruiqi Ma, Yun Cheng, Jihong Wu, Jiang Qian
Uveal melanoma (UM) is the most common intraocular malignant tumor in adults, with a lack of effective treatment for metastasis and a poor prognosis. Stimulator of interferon genes (STING, also known as TMEM173) plays an important role in tumor development by regulating cell proliferation, metastasis and other cellular processes. However, the function of STING in UM remains unclear and requires further
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The advance of the third‑generation EGFR‑TKI in the treatment of non‑small cell lung cancer (Review). Oncol. Rep. (IF 4.2) Pub Date : 2023-12-08 Zhinan Cheng, Hongwei Cui, Yaqi Wang, Jin Yang, Chunyang Lin, Xiaoyu Shi, Yuxiu Zou, Jing Chen, Xiaoqiong Jia, Liqing Su
Lung cancer is currently the second most common type of cancer with the second incidence rate and the first mortality rate worldwide. Non‑small cell lung cancer (NSCLC) accounts for ~85% of the total number of cases of lung cancers. Concerning the treatment of NSCLC, targeted therapy has become a research hotspot in recent years because of its favorable efficacy, high selectivity and minimal adverse
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[Retracted] Effects of miR‑138‑5p and miR‑204‑5p on the migration and proliferation of gastric cancer cells by targeting EGFR. Oncol. Rep. (IF 4.2) Pub Date : 2023-12-08 Yi Wang, Haiyang Zhang, Shaohua Ge, Qian Fan, Likun Zhou, Hongli Li, Ming Bai, Tao Ning, Rui Liu, Xia Wang, Ting Deng, Le Zhang, Guoguang Ying, Yi Ba
Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that the numerous immunohistochemical images shown in Fig. 1D on p. 2626 exhibited a number of overlaps comparing among the data panels, such that data which were intended to show the results from differently performed experiments were likely to have been derived from a smaller number of original
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Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS. Oncol. Rep. (IF 4.2) Pub Date : 2023-12-08 Tomoyuki Nanamiya, Kiyoko Takane, Kiyoshi Yamaguchi, Yuya Okawara, Mariko Arakawa, Akari Saku, Tsuneo Ikenoue, Tomoko Fujiyuki, Misako Yoneda, Chieko Kai, Yoichi Furukawa
PVRL4 (or nectin‑4) is a promising therapeutic target since its upregulated expression is found in a wide range of human cancer types. Enfortumab vedotin, an antibody‑drug conjugate targeting PVRL4, is clinically used for the treatment of urothelial bladder cancer. In addition, rMV‑SLAMblind, a genetically engineered oncolytic measles virus, can infect cancer cells and induce apoptosis through interaction
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SYNPO2 promotes the development of BLCA by upregulating the infiltration of resting mast cells and increasing the resistance to immunotherapy. Oncol. Rep. (IF 4.2) Pub Date : 2023-12-01 Gongjie Ye,Linglan Tu,Zhuduo Li,Xiangyu Li,Xiaoliang Zheng,Yongfei Song
Synaptopodin 2 (SYNPO2) plays a pivotal role in regulating tumor growth, development and progression in bladder urothelial Carcinoma (BLCA). However, the precise biological functions and mechanisms of SYNPO2 in BLCA remain unclear. Based on TCGA database‑derived BLCA RNA sequencing data, survival analysis and prognosis analysis indicate that elevated SYNPO2 expression was associated with poor survival
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Oncogenic role of FOXM1 in human prostate cancer (Review). Oncol. Rep. (IF 4.2) Pub Date : 2023-12-01 Da Young Lee,Jung Nyeo Chun,Insuk So,Ju-Hong Jeon
Prostate cancer is the leading cause of cancer‑related mortality among men worldwide. In particular, castration‑resistant prostate cancer presents a formidable clinical challenge and emphasizes the need to develop novel therapeutic strategies. Forkhead box M1 (FOXM1) is a multifaceted transcription factor that is implicated in the acquisition of the multiple cancer hallmark capabilities in prostate
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[Rectacted] miR‑106b‑5p promotes cell cycle progression of malignant melanoma by targeting PTEN. Oncol. Rep. (IF 4.2) Pub Date : 2023-11-24 Xu-E Chen, Pu Chen, Shan-Shan Chen, Ting Ma, Guang Shi, Ya Zhou, Ji Li, Liang Sheng
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the colony formation data shown in Fig. 2C on p. 333 had already appeared in previously published articles written by different authors at different research institutes. Owing to the fact that the contentious data in the above article had already been published prior to its submission to Oncology
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RPF2 mediates the CARM1‑MYCN axis to promote chemotherapy resistance in colorectal cancer cells. Oncol. Rep. (IF 4.2) Pub Date : 2023-11-24 Macheng Lu, Xingqian Hu, Cong Cheng, Yuan Zhang, Longchang Huang, Xiangpeng Kong, Zengyao Li, Qiuhua Zhang, Ye Zhang
Ribosome production factor 2 homolog (RPF2) plays an important role in the life processes of ribosomal biogenesis; however, the function and mechanism of RPF2 in tumors are unclear. The present study demonstrated that RPF2 expression is involved in chemoresistance in colorectal cancer (CRC) cells. The current study demonstrated that upregulation of RPF2 expression in CRC promoted resistance to chemotherapeutic
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Celastrol enhances TRAIL‑R2‑mediated apoptosis and cytotoxicity in human renal cell carcinoma cells in caspase‑dependent manner. Oncol. Rep. (IF 4.2) Pub Date : 2023-11-24 Yuhang Bao, Xiuxian Wu, Akihiro Kanematsu, Yuki Kita, Takashi Kobayashi, Yoshiyuki Kakehi, Shingo Yamamoto
Celastrol is a triterpene phytochemical known to possess anti‑inflammatory, antioxidant and anticancer properties. The present study investigated the effects of celastrol on tumor necrosis factor‑related apoptosis‑inducing ligand receptor 2 (TRAIL‑R2)‑mediated apoptosis and cytotoxicity in human renal cell carcinoma (RCC) cells when administered in combination with lexatumumab, a human monoclonal agonistic
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Unravelling heterogeneous effects of cancer‑associated fibroblasts on poor prognosis markers in breast cancer EM‑G3 cell line: In vitro‑targeted treatment (anti‑IL-6, anti‑VEGF-A, anti‑MFGE8) based on transcriptomic profiling. Oncol. Rep. (IF 4.2) Pub Date : 2023-11-17 Lukáš Urban, Štepán Novák, Matúš Čoma, Barbora Dvořánková, Lukáš Lacina, Jana Šáchová, Miluše Hradilová, Petra Svatoňová, Michal Kolář, Hynek Strnad, Jana Březinová, Karel Smetana, Peter Gál, Pavol Szabo
Breast cancer is the most frequently diagnosed cancer in women worldwide. Although dramatically increased survival rates of early diagnosed cases have been observed, late diagnosed patients and metastatic cancer may still be considered fatal. The present study's main focus was on cancer‑associated fibroblasts (CAFs) which is an active component of the tumor microenvironment (TME) regulating the breast
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Copy number variations in esophageal squamous cell carcinoma: Emerging cancer drivers and biomarkers (Review). Oncol. Rep. (IF 4.2) Pub Date : 2023-11-17 Jing Ren, Pengzhou Kong, Yanqiang Wang, Dawei Guo, Ling Zhang
The morbidity and mortality of esophageal squamous cell carcinoma (ESCC) remains high in China. ESCC is significantly influenced by a complex interplay of environmental and genetic factors. Copy number variations (CNVs) are a major form of genome‑scale changes in ESCC and are closely related to tumorigenesis and development. Genome‑wide detection and analysis allow the identification of important CNV‑affected
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Regulation of Drp1 and enhancement of mitochondrial fission by the deubiquitinating enzyme PSMD14 facilitates the proliferation of bladder cancer cells. Oncol. Rep. (IF 4.2) Pub Date : 2023-11-17 Wei Song, Zhuo Li, Ming Xia, Wei Xiao
The protein Dynein‑related protein 1 (Drp1) plays a crucial role in regulating the process of mitochondrial fission, which is known to be associated with the onset and progression of various human diseases. However, the specific impact of Drp1 on bladder cancer has yet to be fully understood. In previous studies, evidence to support the theory that the deubiquitinating enzyme proteasome non‑ATPase
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U2AF1 in various neoplastic diseases and relevant targeted therapies for malignant cancers with complex mutations (Review). Oncol. Rep. (IF 4.2) Pub Date : 2023-11-17 Qing Nian, Yihui Li, Jingwei Li, Liyun Zhao, Fernando Rodrigues Lima, Jinhao Zeng, Rongxing Liu, Zhijun Ye
U2 small nuclear RNA auxiliary factor 1 (U2AF1) is a multifunctional protein that plays a crucial role in the regulation of RNA splicing during eukaryotic gene expression. U2AF1 belongs to the SR family of splicing factors and is involved in the removal of introns from mRNAs and exon-exon binding. Mutations in U2AF1 are frequently observed in myelodysplastic syndrome, primary myelofibrosis, chronic
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MicroRNA‑606 inhibits the growth and metastasis of triple‑negative breast cancer by targeting Stanniocalcin 1. Oncol. Rep. (IF 4.2) Pub Date : 2023-11-17 Sujin Choi, Hyun-Ju An, Hyun Jeong Yeo, Min-Ji Sung, Jisu Oh, Kwanbum Lee, Seung Ah Lee, Seung Ki Kim, Junhan Kim, Isaac Kim, Soonchul Lee
Triple‑negative breast cancer (TNBC) is associated with a poor prognosis; however, treatments for TNBC are limited, with poor outcomes. MicroRNAs (miRNAs/miRs) are small non‑coding RNA molecules that are able to regulate gene expression. The present study aimed to identify differentially expressed miRNAs in patients with breast cancer, and to investigate the functional role of the identified miRNA
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[Retracted] miR‑216b inhibits glioma cell migration and invasion through suppression of FoxM1. Oncol. Rep. (IF 4.2) Pub Date : 2023-11-17 Tingting Zhang, Guangtao Ma, Yan Zhang, Hongda Huo, Yuqian Zhao
Following the publication of the above article, a concerned reader reported that certain of the cell invasion assay data shown in Fig. 2D, and the mouse images shown in Fig. 6A, were strikingly similar to data that appeared in the following (subsequently published) article: Li C, Zheng H, Hou W, Bao H, Xiong J, Che W, Gu Y, Sun H and Liang P: Long non-coding RNA linc00645 promotes TGF-β-induced ep
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β‑carotene attenuates muscle wasting in cancer cachexia by regulating myogenesis and muscle atrophy. Oncol. Rep. (IF 4.2) Pub Date : 2023-11-17 Yerin Kim, Yeonsoo Oh, Yoo Sun Kim, Jae-Ho Shin, Yeon Su Lee, Yuri Kim
Cancer cachexia is a metabolic disease involving multiple organs, which is accompanied by the depletion of muscle tissue and is associated with ~20% of cancer‑related deaths. Muscle wasting is a critical factor in cancer cachexia. β‑carotene (BC) has been shown to increase muscle mass and hypertrophy in healthy mice. However, its effects on muscle tissue dysregulation in cancer cachexia have yet to
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Multidrug resistance protein 5 affects cell proliferation, migration and gemcitabine sensitivity in pancreatic cancer MIA Paca‑2 and PANC‑1 cells. Oncol. Rep. (IF 4.2) Pub Date : 2023-11-17 Ji He, Piyush Bugde, Jiawei Li, Riya Biswas, Siting Li, Xuewei Yang, Fang Tian, Zimei Wu, Yan Li
Gemcitabine‑based chemotherapy has been widely adopted as the standard and preferred chemotherapy regimen for treating advanced pancreatic cancer. However, the contribution of multidrug resistance protein 5 (MRP5) to gemcitabine resistance and pancreatic cancer progression remains controversial. In the present study, the effect of silencing MRP5 on gemcitabine resistance and cell proliferation and
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KLF4 suppresses the proliferation of perihilar cholangiocarcinoma by negatively regulating GDF15 and phosphorylating AKT. Oncol. Rep. (IF 4.2) Pub Date : 2023-11-08 Xiaoming Zhang, Weijia Wang, Chunlei Lu, Haifeng Zhang
Krüppel‑like factor 4 (KLF4) is a transcription factor which functions as a tumor suppressor or an oncogene in numerous types of solid tumors. However, its expression levels and function in perihilar cholangiocarcinoma (pCCA) have yet to be elucidated. In the present study, in order to investigate its roles in pCCA, reverse transcription‑quantitative PCR (RT‑qPCR), western blot analysis and immunohistochemistry
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[Retracted] microRNA‑196b promotes cell migration and invasion by targeting FOXP2 in hepatocellular carcinoma. Oncol. Rep. (IF 4.2) Pub Date : 2023-11-08 Zhaoxiang Yu, Xiaobo Lin, Ming Tian, Weiping Chang
Following the publication of the above paper, it was drawn to the Editor's attention by a concerned reader that the images showing metastatic nodules in the mouse lung in Fig. 4 on p. 735 had apparently previously been published a few years earlier in the following paper: Jia D, Yan M, Wang X, Hao X, Liang L, Liu L, Kong H, He X, Li J and Yao M: Development of a highly metastatic model that reveals
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HELQ as a DNA helicase: Its novel role in normal cell function and tumorigenesis (Review). Oncol. Rep. (IF 4.2) Pub Date : 2023-11-03 Nan Tang,Weilun Wen,Zhihe Liu,Xifeng Xiong,Yanhua Wu
Helicase POLQ‑like (HELQ or Hel308), is a highly conserved, 3'‑5' superfamily II DNA helicase that contributes to diverse DNA processes, including DNA repair, unwinding, and strand annealing. HELQ deficiency leads to subfertility, due to its critical role in germ cell stability. In addition, the abnormal expression of HELQ has been observed in multiple tumors and a number of molecular pathways, including
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P53‑microRNA interactions regulate the response of colorectal tumor cells to oxaliplatin under normoxic and hypoxic conditions. Oncol. Rep. (IF 4.2) Pub Date : 2023-11-03 Jiayu Zhang,Chenguang Li,Luanbiao Sun,Denghua Sun,Tiancheng Zhao
Oxaliplatin (OXA)‑containing regimens are used as first‑line chemotherapy in colorectal cancer (CRC). However, OXA resistance remains a major challenge in CRC treatment. CRC cells that adapt to hypoxia can potentially develop OXA resistance, and the underlying molecular mechanisms still need to be further investigated. In the current study, the OXA drug sensitivity of two CRC cell lines, HCT116 (TP53WT)
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Cucurbitacin E inhibits the proliferation of glioblastoma cells via FAK/AKT/GSK3β pathway. Oncol. Rep. (IF 4.2) Pub Date : 2023-11-03 Wen Chen,Fuhong Liu,Xingcheng Lin,Lehui Li,Wenting Chen,Tiantian Zhang,Yuwei Liu,Liyan Niu,Yangbo Zhang,Ping Hu
Glioblastoma (GBM) is the most common primary intracranial tumor in the brain with high growth rate and high mortality rate. Cucurbitacin E (CUE), a tetracyclic triterpene compound derived from species of the genus Cucurbita, has been demonstrated to display significant antitumor effects on various malignancies. In the present study, the effects of CUE on GBM and its underlying molecular mechanisms
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Analysis of the expression and mechanism of follistatin‑like protein 1 in cervical cancer. Oncol. Rep. (IF 4.2) Pub Date : 2023-10-27 Zhen Liu, Hong Zhang, Xiaoxia Hu
The abnormal expression of follistatin‑like protein 1 (FSTL1) in various tumors is a crucial regulator of the biological process of tumorigenesis. Nonetheless, the regulatory role of FSTL1 in cervical cancer is yet to be elucidated. Hence, the present study aimed to explore the expression, function, and molecular mechanism of FSTL1 in cervical cancer. The expression of FSTL1 in normal and cervical
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Heterogeneity and individualized treatment of microenvironment in glioblastoma (Review). Oncol. Rep. (IF 4.2) Pub Date : 2023-10-27 Wei Kang, Zhixiao Mo, Wenshan Li, Haifeng Ma, Qiang Zhang
The heterogeneity of glioblastoma can suppress immune cell function and lead to immune evasion, which presents a challenge in developing effective molecular therapies for tumor cells. However, the study of tumor immune heterogeneity holds great potential for clinical immunotherapy. Liquid biopsy is a useful tool for accurately monitoring dynamic changes in tumor immune heterogeneity and the tumor microenvironment
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Cyclosporin A inhibits prostate cancer growth through suppression of E2F8 transcription factor in a MELK‑dependent manner. Oncol. Rep. (IF 4.2) Pub Date : 2023-10-27 Da Young Lee, Sanghoon Lee, Young Sik Kim, Soonbum Park, Sang-Mun Bae, Eun A Cho, Eun-Jung Park, Hyun Ho Park, Sang-Yeob Kim, Insuk So, Jung Nyeo Chun, Ju-Hong Jeon
The treatment of advanced prostate cancer remains a formidable challenge due to the limited availability of effective treatment options. Therefore, it is imperative to identify promising druggable targets that provide substantial clinical benefits and to develop effective treatment strategies to overcome therapeutic resistance. Cyclosporin A (CsA) showed an anticancer effect on prostate cancer in cultured
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Starvation insult induces the translocation of high mobility group box 1 to cytosolic compartments in glioma. Oncol. Rep. (IF 4.2) Pub Date : 2023-10-27 Xiaohang Cui, Anhui Yao, Liyun Jia
High mobility group box 1 (HMGB1) is a highly conserved and ubiquitous nuclear protein in eukaryotic cells. In response to stress, it transfers from the nucleus to the cytoplasm and finally, to the extracellular matrix, participating in inflammation and carcinogenesis. Increased HMGB1 protein levels are frequently associated with the reduced survival of patients with glioma. HMGB1 plays contextual
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PRMT1 accelerates cell proliferation, migration, and tumor growth by upregulating ZEB1/H4R3me2as in thyroid carcinoma. Oncol. Rep. (IF 4.2) Pub Date : 2023-10-20 Guoli Feng,Changju Chen,Yi Luo
Thyroid carcinoma (TC) represents the most prevalent malignancy of the endocrine system. Protein arginine methyltransferase 1 (PRMT1) is a critical member of the protein arginine methyltransferase family in mammals and is involved in multiple biological processes. This study aimed to investigate the function of PRMT1 in TC. In the present study, human TC cell lines (8505C, CAL62, and BCPAP) and a normal