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Immune infiltration at the primary tumor is associated with clinical outcome of patients with extranodal extension of lymph node metastasis in oral cancer Oral Oncol. (IF 4.8) Pub Date : 2024-04-24 Chieko Michikawa, Frederico O. Gleber-Netto, Curtis R. Pickering, Xiayu Rao, Jing Wang, Andrew G. Sikora, Jeffrey N. Myers, Mitchell J. Frederick
Extranodal extension (ENE) of lymph node metastasis is one of the most reliable prognostic indicators for patients with locally advanced oral cancer. Although multiple reports have found a close relationship between immune infiltration of tumors and patient clinical outcomes, its association with ENE is unknown. We identified 234 human papillomavirus-negative (HPV−) oral cavity squamous cell carcinoma
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Comment on “Prognostic biomarkers in oral squamous cell carcinoma: A systematic review” Oral Oncol. (IF 4.8) Pub Date : 2024-04-22 Muthupandian Saravanan
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Comment on BRAFV600E mutation does not predict lymph node metastases and recurrence in Chinese papillary thyroid microcarcinoma patients Oral Oncol. (IF 4.8) Pub Date : 2024-04-18 Durairaj Sekar
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Outcomes of transoral robotic surgery for early-stage oropharyngeal squamous cell carcinoma with low rates of adjuvant therapy: A consecutive single-institution study from 2013 to 2020 Oral Oncol. (IF 4.8) Pub Date : 2024-04-17 Mukesh Kumar Dharmalingam Jothinathan
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Oncologic and functional results between sentinel lymph node biopsy and elective neck dissection in cT1/2N0 maxillary squamous cell carcinoma Oral Oncol. (IF 4.8) Pub Date : 2024-04-16 Qigen Fang, Junhui Yuan, Xu Zhang, Liyuan Dai, Ruihua Luo, Chunmiao Xu
To evaluate the oncologic safety and quality of life associated with the use of sentinel lymph node biopsy (SLNB) as compared to elective neck dissection (END) in patients with cT1/2N0 maxillary squamous cell carcinoma. This study constituted a retrospective analysis of consecutively treated patients who underwent SLNB or END, with data collected prospectively. We analyzed the impact of the different
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Addressing positive multi-cancer early detection tests in head and neck Surgery: Experience with head and neck work up for high-risk referrals Oral Oncol. (IF 4.8) Pub Date : 2024-04-14 Forrest W. Fearington, Conan Y. Zhao, Santiago Romero-Brufau, Eric J. Moore, Daniel L. Price, Kendall K. Tasche, Linda X. Yin, Elizabeth T. Kunkel, John B. Kisiel, Karthik V. Giridhar, David M. Routman, Kathryn M. Van Abel
Blood-based multi-cancer early detection (MCED) tests are now commercially available. However, there are currently no consensus guidelines available for head and neck cancer (HNC) providers to direct work up or surveillance for patients with a positive MCED test. We seek to describe cases of patients with positive MCED tests suggesting HNC and provide insights for their evaluation. Retrospective chart
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Mutational landscape of oral mucosal melanoma based on comprehensive cancer genomic profiling tests in a Japanese cohort Oral Oncol. (IF 4.8) Pub Date : 2024-04-13 Norihisa Ichimura, Yusuke Urata, Takeru Kobayashi, Hideharu Hibi
Oral mucosal melanoma (OMM) is a rare but aggressive melanoma subtype. Due to its rarity, the genomic landscape of OMM remains unknown despite a relatively thorough understanding of the genetic profile of cutaneous melanoma (CM). In this study, we analyzed the genomic mutational profiles of Japanese patients with OMM and compared them with those of patients with nose/sinuses mucosal melanoma (NMM)
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Secretory carcinoma in the parotid gland presenting as a cystic lesion and harboring ETV6‑NTRK3 gene rearrangement Oral Oncol. (IF 4.8) Pub Date : 2024-04-13 Xiaochen Leng, Xinlong Sun, Yusheng Lin, Cuiping Zhang, Hai Huang, Yuliang Wang
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Oral cancer burden in tribal populations residing in India Oral Oncol. (IF 4.8) Pub Date : 2024-04-13 Pasiyappazham Ramasamy, Saravanan Sekaran, Dhanraj Ganapathy
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The circadian clock gene, BMAL1, promotes radiosensitization in nasopharyngeal carcinoma by inhibiting the epithelial-to-mesenchymal transition via the TGF-β1/Smads/Snail1 axis Oral Oncol. (IF 4.8) Pub Date : 2024-04-13 Yuxin Li, Yu Zhou, Chaofen Zhao, Lina Liu, Qianyong He, Kai Shang, Xinyu Xu, Xunyan Luo, Dingan Zhou, Feng Jin
Acquired radio-resistance is thought to be one of the main causes of recurrent metastasis after failure of nasopharyngeal carcinoma (NPC) radiotherapy, which may be related to X-ray-induced epithelial–mesenchymal transition (EMT) activation. The circadian clock gene, BMAL1, has been shown to correlate with the sensitivity of NPCs to radiotherapy, but the specific mechanism has not been reported. NPC
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Deep learning for the automatic detection and segmentation of parotid gland tumors on MRI Oral Oncol. (IF 4.8) Pub Date : 2024-04-13 Rongli Zhang, Lun M. Wong, Tiffany Y. So, Zongyou Cai, Qiao Deng, Yip Man Tsang, Qi Yong H. Ai, Ann D. King
Parotid gland tumors (PGTs) often occur as incidental findings on magnetic resonance images (MRI) that may be overlooked. This study aimed to construct and validate a deep learning model to automatically identify parotid glands (PGs) with a PGT from normal PGs, and in those with a PGT to segment the tumor. The nnUNet combined with a PG-specific post-processing procedure was used to develop the deep
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Efficacy and Safety of Cell-based Immunotherapy in The Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma – A Systematic Review and Meta-analysis Oral Oncol. (IF 4.8) Pub Date : 2024-04-13 Brian Sheng Yep Yeo, Rachel Siying Lee, Nicholas E-Kai Lim, Ethan Tan, Isabelle Jia Hui Jang, Han Chong Toh, Chwee Ming Lim
Recurrent/Metastatic Nasopharyngeal Carcinoma (RM-NPC) remains difficult to treat and contributes to considerable mortality. The first-line treatment for RM-NPC is Gemcitabine and Cisplatin and second-line treatment options differ. The endemic variant of NPC is associated with Epstein-Barr Virus (EBV). Therefore, Cell-based Immunotherapy (CBI) targeting EBV-specific RM-NPC may be effective. We systematically
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Comment on “Nanomedicine, an emerging therapeutic strategy for oral cancer therapy” Oral Oncol. (IF 4.8) Pub Date : 2024-04-12 Muthupandian Saravanan
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Upfront neck dissection to guide single-modality therapy for early stage supraglottic squamous cell carcinoma Oral Oncol. (IF 4.8) Pub Date : 2024-04-12 Joshua D. Smith, Molly E. Heft-Neal, Andrew J. Rosko, Douglas B. Chepeha, Matthew E. Spector
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Comment on “Awareness regarding oral cancer amongst the dental, medical, and nursing students: Is something lacking?” Oral Oncol. (IF 4.8) Pub Date : 2024-04-12 Paulo Ricardo Elias de Melo, Mariana Agra Monteiro, Helbert Henrique Rocha Aragão, Natália Vitória de Araújo Lopes, John Lennon Silva Cunha
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Cancer stem cells biomarkers and the dynamics of the tumor microenvironment in oral squamous cell carcinoma Oral Oncol. (IF 4.8) Pub Date : 2024-04-11 Manoj Kumar Karuppan Perumal, Remya Rajan Renuka, Guru Prasad Srinivasan, Mukesh Kumar Dharmalingam Jothinathan
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Enhanced oral versus flank lymph node T cell response parallels anti-PD1 efficacy in head and neck cancer Oral Oncol. (IF 4.8) Pub Date : 2024-04-09 Michihisa Kono, Shin Saito, Masahiro Rokugo, Ann Marie Egloff, Ravindra Uppaluri
Understanding head and neck tissue specific immune responses is important for elucidating immunotherapy resistance mechanisms to head and neck squamous cell carcinoma (HNSCC). In this study, we aimed to investigate HNSCC-specific immune response differences between oral and subcutaneous flank tumor transplantation in preclinical models. The MOC1 syngeneic mouse oral carcinoma cell line or versions
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Revolutionizing oral cancer treatment: Harnessing the potential of adaptive CARneg T cell therapy Oral Oncol. (IF 4.8) Pub Date : 2024-04-08 Pitchiah Sivaperumal, Dhanraj Ganapathy, Kannan Kamala
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Cavernous sinus metastasis in head and neck cancer: Focus on oral squamous cell cancer Oral Oncol. (IF 4.8) Pub Date : 2024-04-08 E. Segna, F. Civita, N. Denaro, G.A. Beltramini
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Evaluation of nuclear morphometry in exfoliative cytology of buccal mucosa in patients with high risk of oral cancer Oral Oncol. (IF 4.8) Pub Date : 2024-04-06 Hamrish Kumar Rajakumar, Varsha Coimbatore Sathyabal, Amirtharajan Vivekanandam, Kolsamma Nasrin Jabarulla, Pushpa Balamurugesan
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Comment on “Cell surface expression of 70 kDa heat shock protein in human oral dysplasia and squamous cell carcinoma: Correlation with clinicopathological features” Oral Oncol. (IF 4.8) Pub Date : 2024-04-05 Muthupandian Saravanan
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Extraskeletal Ewing’s sarcoma of supraglottis: A rare case report Oral Oncol. (IF 4.8) Pub Date : 2024-04-05 Mayadevi Poojari, Irappa Madabhavi, Sharad Desai
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Comment on “The microbiome and oral cancer: More questions than answers” Oral Oncol. (IF 4.8) Pub Date : 2024-04-04 Muthupandian Saravanan
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Comment on: Lymph node ratio independently associated with postoperative thyroglobulin levels in papillary thyroid cancer Oral Oncol. (IF 4.8) Pub Date : 2024-04-04 Renli Xu
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Awareness regarding oral cancer amongst the dental, medical, and nursing students: Is something lacking? Oral Oncol. (IF 4.8) Pub Date : 2024-04-03 Rupsa Das, Satya Ranjan Misra, Ananya Nayak
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Comment on “Betel-nut chewing does not influence PD-L1 expression rates in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC): A prospective biomarker prevalence study” Oral Oncol. (IF 4.8) Pub Date : 2024-04-03 Helbert Henrique Rocha Aragão, Mariana Agra Monteiro, Natalia Vitória De Araújo Lopes, John Lennon Silva Cunha
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Outcomes of transoral robotic surgery for early-stage oropharyngeal squamous cell carcinoma with low rates of adjuvant therapy: A consecutive single-institution study from 2013 to 2020 Oral Oncol. (IF 4.8) Pub Date : 2024-04-02 Marius Meldgaard Justesen, Kathrine Kronberg Jakobsen, Amanda-Louise Fenger Carlander, Mikkel Hjordt Holm Larsen, Irene Wessel, Katalin Kiss, Jeppe Friborg, Hani Ibrahim Channir, Niclas Rubek, Christian Grønhøj, Christian von Buchwald
The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased in recent decades, driven by infection with human papillomavirus (HPV). Transoral robotic surgery (TORS) and neck dissection (ND) has been employed as an alternative to radiotherapy/chemoradiotherapy. The current literature is lacking studies providing an exhaustive overview of recurrence characteristics and long-term outcomes
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Comment on circulatory mitochondrial DNA as a novel biomarker for head and neck cancers Oral Oncol. (IF 4.8) Pub Date : 2024-04-01 Xuan Xiao, Zhaocheng Shi, Zhifeng Song
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Long-term stability of jaw reconstruction with microvascular bone flaps: A prospective longitudinal study Oral Oncol. (IF 4.8) Pub Date : 2024-03-30 Jingya Jane Pu, Wing Shan Choi, May C.M. Wong, Songying Wu, Pui Hang Leung, Wei-fa Yang, Yu-Xiong Su
Microvascular bone flap jaw reconstruction has achieved satisfactory clinical outcomes. However, little is known about the long-term stability of the reconstructed jaw. This prospective longitudinal study aimed to investigate the long-term stability of jaw reconstruction and factors that were associated with it. Patients with successful computer-assisted osseous free-flap jaw reconstruction in the
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Tongue cancer in non-smoking and non-alcoholic mother and daughter Oral Oncol. (IF 4.8) Pub Date : 2024-03-30 Diovana de Melo Cardoso, Sebastião Conrado Neto, Francisco Urbano Collado, Cristiane Furuse, Renata Callestini, Vitor Bonetti Valente, Éder Ricardo Biasoli, Glauco Issamu Miyahara, Daniel Galera Bernabé
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Re-irradiation of recurrent head and neck cancers using pulsed reduced dose rate radiotherapy: An institutional series Oral Oncol. (IF 4.8) Pub Date : 2024-03-30 Romy Megahed, Arpan V. Prabhu, Delanie P. Mack, Somayeh Gholami, Santanu Samanta, Mausam Patel, Gary D. Lewis
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What's ahead for complete responders following NACT? Oral Oncol. (IF 4.8) Pub Date : 2024-03-29 Bhargav Ram, Shaurya Verma, Shalini Thakur, Anand Subash, Vishal U.S. Rao, Josephine Joy
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Response to “ impact of tumor subsite on survival outcomes in oral squamous cell carcinoma: A retrospective cohort study from 2000 to 2019″ Oral Oncol. (IF 4.8) Pub Date : 2024-03-28 Arisha Akhtar, Rinad Akhtar
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De novo metastatic head and neck squamous cell carcinoma: Why does locoregional control “always” matter? Oral Oncol. (IF 4.8) Pub Date : 2024-03-28 L. Lorini, R. Gili, V. Salvestrini, I. Morelli, D. Smussi, F. Petrelli, P. Bonomo, P. Bossi
De novo metastatic Head and Neck Squamous Cell Carcinoma (HNSCC) constitutes 10% of recurrent/metastatic (RM) cases. Radiotherapy (RT) has a crucial role in the treatment of locally advanced HNSCC, however its application on RM diseases is still limited. The advent of immune checkpoint inhibitors (ICIs) improves the survival of RM HNSCC, however median overall survival is still limited. Integration
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BRAFV600E mutation does not predict lymph node metastases and recurrence in Chinese papillary thyroid microcarcinoma patients Oral Oncol. (IF 4.8) Pub Date : 2024-03-28 Hao Zhao, Chun-hao Liu, Ying Lu, Shu-Zhou Liu, Palashate Yeerkenbieke, Yue Cao, Yu Xia, Lu-Ying Gao, Yue-Wu Liu, Zi-Wen Liu, Shu-Guang Chen, Zhi-Yong Liang, Xiao-Yi Li
Object: Previous studies suggest BRAF mutation is a marker for poor prognosis in papillary thyroid cancer, however, its ability to further risk stratify papillary thyroid microcarcinoma (PTMC) remains controversial. We aimed to explore the association between BRAF mutation and the clinicopathological features and recurrence in Chinese PTMC patients. We retrospectively reviewed 2094 PTMC patients who
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An algorithm for standardization of tumor Infiltrating lymphocyte evaluation in head and neck cancers Oral Oncol. (IF 4.8) Pub Date : 2024-03-27 Vasiliki Xirou, Myrto Moutafi, Yalai Bai, Thazin Nwe Aung, Sneha Burela, Matthew Liu, Randall J. Kimple, Fahad Shabbir Ahmed, Bryant Schultz, Douglas Flieder, Denise C. Connolly, Amanda Psyrri, Barbara Burtness, David L. Rimm
The prognostic and predictive significance of pathologist-read tumor infiltrating lymphocytes (TILs) in head and neck cancers have been demonstrated through multiple studies over the years. TILs have not been broadly adopted clinically, perhaps due to substantial inter-observer variability. In this study, we developed a machine-based algorithm for TIL evaluation in head and neck cancers and validated
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Betel-nut chewing does not influence PD-L1 expression rates in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC): A prospective biomarker prevalence study Oral Oncol. (IF 4.8) Pub Date : 2024-03-23 Ruey-Long Hong, Chia-Jui Yen, Ming-Yu Lien, Rebecca Cheng, Yu-Wen Su, Han-Nan Lin, Song Ling Poon, Chih-Yen Chien
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Use of the spider limb positioner for fibular free flap reconstruction of head and neck bony defects Oral Oncol. (IF 4.8) Pub Date : 2024-03-22 Joshua D. Smith, Shaum S. Sridharan, Kevin J. Contrera, Jeremy D. Richmon, Allen L. Feng, Steven B. Chinn, Molly E. Heft-Neal, Matthew E. Spector
Osseous and osteocutaneous fibular free flaps are the workhorse of maxillomandibular reconstruction over 30 years after the initial description. Since 2019, we have routinely used the Spider Limb Positioner, adapted from its use in shoulder orthopedic procedures, for fibular free flap harvest. Herein, we describe this novel technique in our cohort. We describe our intraoperative setup and endorse the
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How reliable is assessment of true vocal cord-arytenoid unit mobility in patients affected by laryngeal cancer? a multi-institutional study on 366 patients from the ARYFIX collaborative group Oral Oncol. (IF 4.8) Pub Date : 2024-03-22 M. Ferrari, F. Mularoni, S. Taboni, E. Crosetti, C. Pessina, A.L.C. Carobbio, N. Montalto, F. Marchi, A. Vural, A. Paderno, S. Caprioli, P. Gaudioso, M. Fermi, F. Rigoni, T. Saccardo, G. Contro, A. Ruaro, A. Lo Manto, C. Varago, M. Baldovin, L. Bandolin, M. Filauro, C. Sampieri, F. Missale, A. Ioppi, F. Carta, M. Ramanzin, M. Ravanelli, V. Maiolo, I. Bertotto, F. Del Bon, D. Lancini, C. Mariani, V
In clinical practice the assessment of the “vocal cord-arytenoid unit” (VCAU) mobility is crucial in the staging, prognosis, and choice of treatment of laryngeal squamous cell carcinoma (LSCC). The aim of the present study was to measure repeatability and reliability of clinical assessment of VCAU mobility and radiologic analysis of posterior laryngeal extension. In this multi-institutional retrospective
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Radiation Therapy Oncology Group 8502 “QUAD shot” regimen using volumetric modulated arc therapy for incurable head and neck cancer Oral Oncol. (IF 4.8) Pub Date : 2024-03-21 Ryo Toya, Yoshiyuki Fukugawa, Tetsuo Saito, Tomohiko Matsuyama, Ryoji Yoshida, Daizo Murakami, Yorihisa Orita, Hideki Nakayama, Natsuo Oya
We aimed to evaluate the outcomes of the Radiation Therapy Oncology Group 8502 “QUAD shot” regimen using volumetric modulated arc therapy (VMAT) for incurable head and neck cancer (HNC). We included 105 patients with HNC in the study, undergoing at least one QUAD shot regimen cycle. We planned the radiotherapy using VMAT with 6 MV photons. One QUAD shot cycle included 14.8 Gy in 4 fractions with at
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Twelve years after: The french national network on rare head and neck tumours (REFCOR) Oral Oncol. (IF 4.8) Pub Date : 2024-03-20 Cassandre Gasne, Sarah Atallah, Etienne Dauzier, Juliette Thariat, Nicolas Fakhry, Benjamin Verillaud, Marion Classe, Sebastien Vergez, Antoine Moya-Plana, Valerie Costes-Martineau, Christian Righini, Ludovic de Gabory, Laurence Digue, Charles Dupin, François Régis Ferrand, Caroline Even, Bertrand Baujat, On behalf of REFCOR members
Rare cancers constitute less than 10% of head and neck cancers and lack sufficient evidence for standardized care. The French Rare Head and Neck Cancer Expert Network (REFCOR) as established a national database to collect data on these rare cancers. This study aims to describe patient and tumour characteristics in this database. Prospective data collection was conducted across multiple centers. Survival
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Immunotherapy time of infusion impacts survival in head and neck cancer: A propensity score matched analysis Oral Oncol. (IF 4.8) Pub Date : 2024-03-20 Daniel A. Ruiz-Torres, Saskia Naegele, Archana Podury, Lori Wirth, Sophia Z. Shalhout, Daniel L. Faden
The adaptive immune response is physiologically regulated by the circadian rhythm. Data in lung and melanoma malignancies suggests immunotherapy infusions earlier in the day may be associated with improved response; however, the optimal time of administration for patients with head and neck squamous cell carcinoma (HNSCC) is not known. We aimed to evaluate the association of immunotherapy infusion
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Prognostic value of tumor volume doubling time in lung-metastatic adenoid cystic carcinoma Oral Oncol. (IF 4.8) Pub Date : 2024-03-19 Eduardo A. Dal Lago, Luana G. Sousa, Zixi Yang, Camilla O. Hoff, Flavia Bonini, Matthew Sawyer, Kaiwen Wang, Whitney Lewis, Kareem A. Wahid, Ehab Y. Hanna, Adel El-Naggar, Clifton D. Fuller, Suprateek Kundu, Myrna Godoy, Renata Ferrarotto
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Human Papilloma Virus-16 associated primary adenocarcinoma of the tonsil: Report of two cases and literature review Oral Oncol. (IF 4.8) Pub Date : 2024-03-18 Anthony Waton, Anne Chambers, Hannah Fox, James O'Hara, Muhammad Shahid Iqbal
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In reply to Melachuri et al. (https://doi.org/10.1016/j.oraloncology.2024.106703) Oral Oncol. (IF 4.8) Pub Date : 2024-03-18 Erkan Topkan, Efsun Somay, Uğur Selek
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Challenges in the diagnosis of oral squamous cell carcinoma mimicking medication-related osteonecrosis of the jaws: a multi-hospital-based case series Oral Oncol. (IF 4.8) Pub Date : 2024-03-18 Rodolfo Mauceri, Martina Coppini, Mario Pérez-Sayáns, Corrado Toro, Rita Vitagliano, Giuseppe Colella, Vito Rodolico, Giuseppina Campisi
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Medicare dental coverage for patients with head and neck cancer: An opportunity in need of advocates Oral Oncol. (IF 4.8) Pub Date : 2024-03-16 Lisa Simon, Jonathan Paly, Elyse Park, Margaret Samuels-Kalow
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MYB alternative promoter activity is increased in adenoid cystic carcinoma metastases and is associated with a specific gene expression signature Oral Oncol. (IF 4.8) Pub Date : 2024-03-16 Junchi Huang, André Fehr, Fredrik Jäwert, Jonas A. Nilsson, Luc G.T. Morris, Göran Stenman, Mattias K. Andersson
Adenoid cystic carcinoma (ACC) is a head and neck cancer with a poor long-term prognosis that shows frequent local recurrences and distant metastases. The tumors are characterized by oncogene activation and are notoriously unresponsive to systemic therapies. The biological underpinnings behind therapy resistance of disseminated ACC are largely unknown. Here, we have studied the molecular and clinical
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Does a biopsy improve the diagnosis of oral lichen planus and management of the patient? In which scenario does the malignant transformation matter most? Oral Oncol. (IF 4.8) Pub Date : 2024-03-15 Dante Migliari
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Comment on “advancing oral cancer diagnosis in Brazil: Integrating artificial intelligence with Teledentistry for Better Patient Outcomes” Oral Oncol. (IF 4.8) Pub Date : 2024-03-15 Paulo Ricardo Elias de Melo, Mariana Agra Monteiro, Natália Vitória de Araújo Lopes, John Lennon Silva Cunha
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Comment on “A case report on a nasal and oral cavity involving large solitary fibrous tumor and comprehensive review of case literature” Oral Oncol. (IF 4.8) Pub Date : 2024-03-14 John Lennon Silva Cunha, Bruno Augusto Benevenuto de Andrade, Jorge Esquiche León
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Association between COVID 19 exposure and expression of malignant pathological features in oral squamous cell carcinoma: A retrospective cohort study Oral Oncol. (IF 4.8) Pub Date : 2024-03-14 Yufei Hua, Pingchuan Ma, Chunjie Li, Ning Gao, Zhangfan Ding
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Differential expression of TRKB tyrosine kinase in the two histological types of parotid salivary duct carcinoma with cancer aggressiveness Oral Oncol. (IF 4.8) Pub Date : 2024-03-12 Kazumasa Moriwaki, Yusuke Ayani, Hiroko Kuwabara, Tetsuya Terada, Masaaki Higashino, Ryo Kawata
Parotid salivary duct carcinoma (SDC) is a rare and aggressive parotid gland carcinoma (PGC). SDC has two origins: and ex pleomorphic adenoma (SDC ex PA); however, because of its rarity, the clinical and molecular features of the two types of SDC are not sufficiently understood. Here, we studied the differences in their clinicopathological and molecular features using clinical specimens while comparing
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Exosomal immune checkpoint protein (PD-L1): Hidden player in PD-1/PD-L1 blockade immunotherapy resistance in oral cancer Oral Oncol. (IF 4.8) Pub Date : 2024-03-11 Jeevitha Rajanathadurai, Jospin Sindya, Inamul Hasan Madar, Elumalai Perumal
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Human papillomavirus (HPV) load is higher in HPVDNA/p16 positive than in HPVDNA positive/p16 negative oropharyngeal squamous cell carcinoma but does not differ significantly between various subsites or correlate to survival Oral Oncol. (IF 4.8) Pub Date : 2024-03-10 Mark Zupancic, Ourania N. Kostopoulou, Stefan Holzhauser, Monika Lukoseviciute, Cecilia Jylhä, Linda Marklund, Anders Näsman, Lars Sivars, Tina Dalianis
Patients with human papillomavirus DNA positive (HPVDNA) and p16 overexpressing (p16) oropharyngeal squamous cell carcinoma (OPSCC), especially those with cancer in the tonsillar and base of tongue subsites as compared to other OPSCC subsites have a better outcome than those with only HPVDNA or only p16 cancer. Likewise having a high viral load has been suggested to be a positive prognostic factor
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Role of telemedicine in head neck cancer Oral Oncol. (IF 4.8) Pub Date : 2024-03-09 Shrikant B. Mali
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Atezolizumab plus bevacizumab in advanced Merkel cell carcinoma: A prospective study Oral Oncol. (IF 4.8) Pub Date : 2024-03-08 L. Guimaraes de Sousa, S. Liu, P. Bhosale, M. Altan, W. Darbonne, K. Schulze, S. Dervin, C. Yun, A. Mahvash, A. Verma, A. Futreal, S. Gite, E. Parra Cuentas, W.C. Cho, I. Wistuba, J.C. Yao, S.E. Woodman, D.M. Halperin, R. Ferrarotto
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Should sub-millimeter margins be deemed positive in oral cavity squamous cell carcinoma? Oral Oncol. (IF 4.8) Pub Date : 2024-03-08 Chung-Jan Kang, Li-Yu Lee, Shu-Hang Ng, Chien-Yu Lin, Kang-Hsing Fan, Wen-Cheng Chen, Jin-Ching Lin, Yao-Te Tsai, Shu-Ru Lee, Chih-Yen Chien, Chun-Hung Hua, Cheng Ping Wang, Tsung-Ming Chen, Shyuang-Der Terng, Chi-Ying Tsai, Hung-Ming Wang, Chia-Hsun Hsieh, Chih-Hua Yeh, Chih-Hung Lin, Chung-Kan Tsao, Nai-Ming Cheng, Tuan-Jen Fang, Shiang-Fu Huang, Li-Ang Lee, Ku-Hao Fang, Yu-Chien Wang, Wan-Ni Lin
While several studies have indicated that a margin status of < 1 mm should be classified as a positive margin in oral cavity squamous cell carcinoma (OCSCC), there is a lack of extensive cohort studies comparing the clinical outcomes between patients with positive margins and margins < 1 mm. Between 2011 and 2020, we identified 18,416 Taiwanese OCSCC patients who underwent tumor resection and neck
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The utility of ultrasonographic surveillance in management of a presumed branchial cleft cyst later confirmed HPV-associated oropharyngeal cancer Oral Oncol. (IF 4.8) Pub Date : 2024-03-08 Tatiana Ferraro, Alisha R. Pershad, Shaleen Arora, Esther Lee, Arjun Joshi