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Benzo[a]pyrene promotes an epithelial‐to‐mesenchymal transition process in MCF10A cells and mammary tumor growth and brain metastasis in female mice Mol. Carcinog. (IF 4.6) Pub Date : 2024-04-17 Rocio Castillo‐Sanchez, Alejandra Garcia‐Hernandez, Pablo Torres‐Alamilla, Pedro Cortes‐Reynosa, Fernando Candanedo‐Gonzales, Eduardo Perez Salazar
Breast cancer is the most frequent neoplasia in developed countries and the leading cause of death in women worldwide. Epithelial‐to‐mesenchymal transition (EMT) is a cellular process through which epithelial cells decrease or lose their epithelial characteristics and gain mesenchymal properties. EMT mediates tumor progression, because tumor cells acquire the capacity to execute the multiple steps
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Four and a half LIM domains 2 (FHL2) attenuates tumorigenesis of gastrointestinal stromal tumors (GISTs) by negatively regulating KIT signaling Mol. Carcinog. (IF 4.6) Pub Date : 2024-04-17 Shaoting Zhang, Liangying Zhang, Dan Zhang, Yue Guo, Yisha Gao, Zongying Jiang, Shujing Li, Anbu Liu, Xu Cao, Jinhai Tian, Sien Zhao, Yuanyuan Yu, Wei Yang, Ru Bai, Ling Huang, Hongli Yan, Hui Zhao, Jianmin Sun
Gastrointestinal stromal tumors (GISTs) are predominately induced by KIT mutants. In this study, we found that four and a half LIM domains 2 (FHL2) was highly expressed in GISTs and KIT signaling dramatically increased FHL2 transcription while FHL2 inhibited KIT transcription. In addition, our results showed that FHL2 associated with KIT and increased the ubiquitination of both wild‐type KIT and primary
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Cover Image, Volume 63, Issue 5 Mol. Carcinog. (IF 4.6) Pub Date : 2024-04-17 Mengqiu Song, Yingzi Qu, Huajie Jia, Yunqing Zhang, Shihui Liu, Kyle Vaughn Laster, Bu Young Choi, Jie Tian, Tingxuan Gu, Hanyong Chen, Kangdong Liu, Mee‐Hyun Lee, Zigang Dong
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Baicalein promotes KDM4E to induce BICD1 and inhibit triple‐negative breast cancer progression by blocking PAR1 signaling Mol. Carcinog. (IF 4.6) Pub Date : 2024-04-12 Yun Dong, Gaojian He, Kun Chen, Xuefeng He, Meitong Pan, Xuemei Huang, Xiaolan Yu, Jiyi Xia
Baicalein has been implicated in the chemotherapy overcoming triple‐negative breast cancer (TNBC). However, many unanswered questions remain regarding its role in treating TNBC. Here, we sought to demonstrate the molecular pathway mediated by baicalein in TNBC. Lysine‐specific demethylase 4E (KDM4E), reduced in TNBC cells, was identified as a target protein of baicalein, and baicalein enhanced the
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Hypomethylation‐associated LINC00987 downregulation induced lung adenocarcinoma progression by inhibiting the phosphorylation‐mediated degradation of SND1 Mol. Carcinog. (IF 4.6) Pub Date : 2024-04-12 Qi Lai, Yulin Wan, Yingqian Zhang, Yingzhao Huang, Qiuyue Tang, Mei Chen, Qian Li, Ke Ma, Ping Xiao, Cheng Luo, Xiang Zhuang
DNA methylation, an epigenetic regulatory mechanism dictating gene transcription, plays a critical role in the occurrence and development of cancer. However, the molecular underpinnings of LINC00987 methylation in the regulation of lung adenocarcinoma (LUAD) remain elusive. This study investigated LINC00987 expression in LUAD patients through analysis of The Cancer Genome Atlas data sets. Quantitative
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HHLA2 promotes hepatoma cell proliferation, migration, and invasion via SPP1/PI3K/AKT signaling pathway Mol. Carcinog. (IF 4.6) Pub Date : 2024-04-05 Junqi Wang, Ke Yang, Xin Yang, Tianqiang Jin, Yu Tian, Chaoliu Dai, Feng Xu
Hepatocellular carcinoma (HCC) stands as one of the most malignant tumors characterized by poor prognosis and high mortality rates. Emerging evidence underscores the crucial role of the B7 protein family in various cancers, including HCC. However, the involvement of the human endogenous retrovirus H long‐terminal repeat‐associated protein 2 (HHLA2, or B7‐H5) in HCC remains unclear. Immunohistochemistry
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VDX‐111, a novel small molecule, induces necroptosis to inhibit ovarian cancer progression Mol. Carcinog. (IF 4.6) Pub Date : 2024-04-01 Christianne Persenaire, Beatrice Babbs, Tomomi M. Yamamoto, Morgan Nebbia, Kimberly R. Jordan, Sarah Adams, James R. Lambert, Benjamin G. Bitler
Epithelial ovarian cancers that are nonhomologous recombination deficient, as well as those that are recurrent and in a platinum‐resistant state, have limited therapeutic options. The objectives of this study were to characterize the mechanism of action and investigate the therapeutic potential of a small molecule, VDX‐111, against ovarian cancer. We examined the ability of VDX‐111 to inhibit the growth
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ENO1 contributes to the gemcitabine resistance of pancreatic cancer through the YAP1 signaling pathway Mol. Carcinog. (IF 4.6) Pub Date : 2024-03-22 Hongqin Ma, Lulu Kong, Li Liu, Yusheng Du, Xinguo Zhu, Ji Wang, Wenxing Zhao
Pancreatic cancer (PC), a leading cause of cancer‐related deaths, has a 5‐year survival rate of approximately 10%. α‐Enolase (ENO1) is a junction channel protein involved in tumor cell apoptosis and chemoresistance. However, the role of ENO1 in PC remains unclear. The expression and prognosis of ENO1 levels were determined in PC using public databases based on The Cancer Genome Atlas (TCGA) data sets
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Loss of PTPRS elicits potent metastatic capability and resistance to temozolomide in glioblastoma Mol. Carcinog. (IF 4.6) Pub Date : 2024-03-22 Yihua Zhang, Liugang Chang, Ping Huang, Min Cao, Rujun Hong, Xinhu Zhao, Xuzhi He, Lunshan Xu
Glioblastoma (GBM) is the most aggressive brain tumor type with worse clinical outcome due to the hallmarks of strong invasiveness, high rate of recurrence, and therapeutic resistance to temozolomide (TMZ), the first‐line drug for GBM, representing a major challenge for successful GBM therapeutics. Understanding the underlying mechanisms that drive GBM progression will shed novel insight into therapeutic
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Drug-target Mendelian randomization revealed a significant association of genetically proxied metformin effects with increased prostate cancer risk Mol. Carcinog. (IF 4.6) Pub Date : 2024-03-22 Xiaohui Sun, Jie Ping, Xingyi Guo, Jirong Long, Qiuyin Cai, Xiao-ou Shu, Xiang Shu
The association between metformin use and risk of prostate cancer remains controversial, while data from randomized trials is lacking. We aim to evaluate the association of genetically proxied metformin effects with prostate cancer risk using a drug-target Mendelian randomization (MR) approach. Summary statistics for prostate cancer were obtained from the Prostate Cancer Association Group to Investigate
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Effect of nonsteroidal anti‐inflammatory drugs (aspirin and naproxen) on inflammation‐associated proteomic profiles in mouse plasma and prostate during TMPRSS2‐ERG (fusion)‐driven prostate carcinogenesis Mol. Carcinog. (IF 4.6) Pub Date : 2024-03-20 Ram Raj Prasad, Neha Mishra, Rama Kant, Jennifer T. Fox, Robert H. Shoemaker, Chapla Agarwal, Komal Raina, Rajesh Agarwal
Recent preclinical studies have shown that the intake of nonsteroidal anti‐inflammatory drugs (NSAIDs) aspirin and naproxen could be an effective intervention strategy against TMPRSS2‐ERG fusion‐driven prostate tumorigenesis. Herein, as a follow‐up mechanistic study, employing TMPRSS2‐ERG (fusion) positive tumors and plasma from TMPRSS2‐ERG. Ptenflox/flox mice, we profiled the stage specific proteomic
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The RNA‐binding protein sorbin and SH3 domain‐containing 2 are transcriptionally regulated by specificity protein 1 and function as tumor suppressors in bladder cancer by stabilizing tissue factor pathway inhibitor Mol. Carcinog. (IF 4.6) Pub Date : 2024-03-19 Beibei Wang, Xin Fan, Lingang Wang, Xiaosong Wei
Sorbin and SH3 domain‐containing 2 (SORBS2) is an RNA‐binding protein and has been implicated in the development of some cancers. However, its role in bladder cancer (BC) is yet to be established. The expression of SORBS2 in BC tissues was determined from the Gene Expression Omnibus and Gene Expression Profiling Interactive Analysis databases and collected paired tumor/normal samples. The effects of
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Ligand‐gated ion channels as potential biomarkers for ADT‐mediated cognitive decline in prostate cancer patients Mol. Carcinog. (IF 4.6) Pub Date : 2024-03-14 Shiv Verma, Vaibhav Singh, VijayKrishna Nagampalli, Lee E. Ponsky, Chiang‐Shan R. Li, Herta Chao, Sanjay Gupta
Men with prostate cancer are at increased risk of developing cognitive decline by the use of second‐generation androgen signaling inhibitors. To date, reliable and sensitive biomarkers that could distinguish men at high risk of cognitive dysfunction under androgen deprivation therapy (ADT) have not been characterized. We used high‐throughput transcriptional profiling utilizing human prostate cancer
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BATF promotes extramedullary infiltration through TGF‐β1/Smad/MMPs axis in acute myeloid leukemia Mol. Carcinog. (IF 4.6) Pub Date : 2024-03-13 Ru Zhang, Jiyu Miao, Meng Zhai, Rui Liu, Fangmei Li, Xuezhu Xu, Lingjuan Huang, Ting Wang, Rui Yang, Ruoyu Yang, Yiwen Wang, Aili He, Jianli Wang
Acute myeloid leukemia (AML) is one of the most prevalent types of leukemia and is challenging to cure for most patients. Basic Leucine Zipper ATF‐Like Transcription Factor (BATF) has been reported to participate in the development and progression of numerous tumors. However, its role in AML is largely unknown. In this study, the expression and prognostic value of BATF were examined in AML. Our results
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Tectoridin inhibits the growth of bladder cancer by regulating PI3K/MAPK pathway through RAB27B Mol. Carcinog. (IF 4.6) Pub Date : 2024-03-05 Qianjin Zhang, Leiyu Wang, Lei Yu, Quansheng Yu, Liuqing Xue, Zhiyong Shen
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Bruceantinol targeting STAT3 exerts promising antitumor effects in in vitro and in vivo osteosarcoma models Mol. Carcinog. (IF 4.6) Pub Date : 2024-03-01 Jinglei Miao, Shijie Chen, Hongqing Cao, Zhiyu Ding, Yuezhan Li, Weiguo Wang, Keshav Nundlall, Youwen Deng, Jinsong Li
Bruceantinol (BOL) is a quassinoid compound found in the fruits of Brucea javanica. Previous research has highlighted the manifold physiological and pharmacological activities of BOL. Notably, BOL has demonstrated antitumor cytotoxic and antibacterial effects, lending support to its potential as a promising therapeutic agent for various diseases. Despite being recognized as a potent antitumor inhibitor
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ELOVL6 promotes the progression of head and neck squamous cell carcinoma via activating WNT/β‐catenin pathway Mol. Carcinog. (IF 4.6) Pub Date : 2024-03-01 Ruoya Wang, Xianzhi Liu, Xiyao Li, Ming Qian, Xi Yang, Qichuan Jiang, Yijie Wang, Hao Liu, Jianguo Chen, Xuefeng Wang, Liang Gong
This study was to explore the role of ELOVL6 in the development of head and neck squamous cell carcinoma (HNSCC). Considering its previously identified oncogenic role in hepatocellular carcinoma. ELOVL6 gene expression, clinicopathological analysis, enrichment analysis, and immune infiltration analysis were based on the data from Gene Expression Omnibus and The Cancer Genome Atlas, with additional
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The small nucleolar RNA SNORA51 enhances breast cancer stem cell‐like properties via the RPL3/NPM1/c‐MYC pathway Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-29 Shan Li, Zining Jin, Xinyue Song, Jinfei Ma, Ziqi Peng, Hao Yu, Jian Song, Yiqi Zhang, Xiaoyu Sun, Miao He, Xinmiao Yu, Feng Jin, Ang Zheng
Breast cancer stem cells (BCSCs) are key players in carcinogenesis and development. Small nucleolar RNAs (snoRNAs) seem to have a crucial influence on regulating stem cell‐like properties in various cancers, but the underlying mechanism in breast cancer has not been determined. In this study, we first found that the expression of SNORA51 might be strongly and positively related to BCSCs‐like properties
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Effect of CHRDL1 on angiogenesis and metastasis of colorectal cancer cells via TGF‐β/VEGF pathway Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-28 Junfeng Li, Zhongxiang Jiang, Jin He, Kun Yang, Jun Chen, Qianxi Deng, Xiaoqing Li, Fan Wu, Shuman Xu, Zheng Jiang
Colorectal cancer (CRC) is a common digestive tract tumor with the third incidence and death in the world. There is still an urgent need for effective therapeutic targets and prognostic markers for CRC. Herein, we report a novel potential target and marker, Chordin like‐1 (CHRDL1). The function of CHRDL1 has been reported in gastric cancer, breast cancer, and oral squamous cell carcinoma. However,
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NSUN2 promotes lung adenocarcinoma progression through stabilizing PIK3R2 mRNA in an m5C-dependent manner Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-27 Xuan Du, Cheng Cheng, Yi Yang, Bowen Fan, Peiwen Wang, Haibo Xia, Xinye Ni, Qizhan Liu, Lu Lu, Lei Wei
It is well known that 5-methylcytosine (m5C) is involved in variety of crucial biological processes in cancers. However, its biological roles in lung adenocarcinoma (LAUD) remain to be determined. The LUAD samples were used to assess the clinical value of NOP2/Sun RNA Methyltransferase 2 (NSUN2). Dot blot was used to determine global m5C levels. ChIP and dual-luciferase assays were performed to investigate
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Metabolism‐focused CRISPR screen unveils mitochondrial pyruvate carrier 1 as a critical driver for PARP inhibitor resistance in lung cancer Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-27 Takashi Furusawa, Renzo Cavero, Yue Liu, Haojian Li, Xia Xu, Thorkell Andresson, William Reinhold, Olivia White, Myriem Boufraqech, Thomas J. Meyer, Oliver Hartmann, Markus E. Diefenbacher, Yves Pommier, Urbain Weyemi
Homologous recombination (HR) and poly ADP‐ribosylation are partially redundant pathways for the repair of DNA damage in normal and cancer cells. In cell lines that are deficient in HR, inhibition of poly (ADP‐ribose) polymerase (poly (ADP‐ribose) polymerase [PARP]1/2) is a proven target with several PARP inhibitors (PARPis) currently in clinical use. Resistance to PARPi often develops, usually involving
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Corrigendum to “Nexrutine inhibits azoxymethane-induced colonic aberrant crypt formation in rat colon and induced apoptotic cell death in colon adenocarcinoma cells” Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-27
Alam, S., Pal, A., Kumar, R., Mir, S. S., & Ansari, K. M. (2016). Nexrutine inhibits azoxymethane-induced colonic aberrant crypt formation in rat colon and induced apoptotic cell death in colon adenocarcinoma cells. Molecular Carcinogenesis, 55(8), 1262–1274. doi:10.1002/mc.22368 Following the publication of the above article, the authors noticed that β-actin blots used for Bax/Bcl2, Caspase 3/9, and
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JD‐02, a novel Hsp90 inhibitor, induces ROS/SRC axis‐dependent cytoprotective autophagy in colorectal cancer cells Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-27 Ni Lan, Yuan Su, Qiongzhen Zeng, Pengjun Zhou, Yuze Hu, Zhuo Zhang, Yifei Wang, Kaisheng Liu
Heat shock protein 90 (Hsp90) is a tumor marker that accelerates cancer growth by disrupting protein homeostasis. However, concerns such as low clinical efficacy and drug resistance continue to be obstacles to the successful marketing of Hsp90 inhibitors. The cytoprotective function of autophagy has been identified as one of the mechanisms by which tumor cells gain resistance to chemotherapy. JD‐02
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Sciellin promotes the development and progression of thyroid cancer through the JAK2/STAT3 signaling pathway Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-27 Haohao Guo, Ziyang Wang, Keyu Yin, Runsheng Ma, Yifei Zhang, Fanxiang Yin, Hongqiang Li, Detao Yin
Thyroid cancer (TC) is one of the most common endocrine tumors worldwide. Sciellin (SCEL) is involved in various disease processes, including burn wound healing and neutrophil extracellular traps (NETs); it is highly expressed in TC. However, its biological impact on TC and related mechanisms remain unclear. This study aimed to investigate the effect of SCEL on the function of human TC cell lines B-CPAP
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Alternative splicing‐related long noncoding RNA ANRIL facilitates hepatocellular carcinoma by targeting the miR‐199a‐5p/SRSF1 axis and impacting Anillin Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-27 Yifan Zhang, Yiquan Lu, Nan Wang, Yuchen Yang, Fengjie Hao, Xiaochun Fei, Yongjun Chen, Junqing Wang
Hepatocellular carcinoma (HCC) is characterized by aberrant alternative splicing (AS), which plays an important part in the pathological process of this disease. However, available reports about genes and mechanisms involved in AS process are limited. Our previous research has identified ANRIL as a long noncoding RNA related to the AS process of HCC. Here, we investigated the exact effect and the mechanism
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TMED3 stabilizes SMAD2 by counteracting NEDD4-mediated ubiquitination to promote ovarian cancer Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-27 Xiaojun Chen, Wei Zhang, Xiaotian Han, Xiaoqi Li, Lingfang Xia, Yong Wu, Yang Zhou
Ovarian cancer is a major cause of death among cancer patients. Recent research has shown that the transmembrane emp24 domain (TMED) protein family plays a role in the progression of various types of cancer. In this study, we investigated the expression of TMED3 in ovarian cancer tumors compared to nontumor tissues using immunohistochemical staining. We found that TMED3 was overexpressed in ovarian
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GOLPH3 promotes tumor malignancy via inhibition of ferroptosis by upregulating SLC7A11 in cholangiocarcinoma Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-23 Zheng Yin, Qi Liu, Ying Gao, Ruizhi Wang, Yunling Qi, Dong Wang, Lianzhou Chen, Xiaoyu Yin, Meifang He, Wen Li
Golgi phosphoprotein 3 (GOLPH3) has been reported as an oncogene in various tumors; however, the role and function of GOLPH3 and its relevant molecular mechanism in cholangiocarcinoma (CCA) are unclear. Herein, GOLPH3 expression in CCA tissues was observed to be significantly higher than that in paired adjacent noncancerous tissues. Clinicopathological analysis showed that GOLPH3 expression correlated
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Genetic susceptibility to prostate cancer in Taiwan: A genome-wide association study Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-23 Da-Tian Bau, Chia-Wen Tsai, Wen-Shin Chang, Jai-Sing Yang, Ting-Yuan Liu, Hsing-Fang Lu, Yu-Wen Wang, Fuu-Jen Tsai
We conducted the first genome-wide association study (GWAS) of prostate cancer (PCa) in Taiwan with 1844 cases and 80,709 controls. Thirteen independent single-nucleotide polymorphisms (SNPs) reached genome-wide significance (p < 5 × 10−8). Among these, three were distinct from previously identified loci: rs76072851 in CORO2B gene (15q23), odds ratio (OR) = 1.54, 95% confidence interval (CI), 1.36–1
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FTO promotes the progression of retinoblastoma through YTHDF2-dependent N6-methyladenosine modification in E2F3 Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-21 Weiwei Xie, Yongqing Shao, Qingyun Bo, Zhen Li, Qihua Yu, Layi Wang, Guohai Wu
Early treatment of retinoblastoma (RB) has significantly improved clinical outcomes. N6-methyladenosine (m6A) methylation is crucial for cancer progression. Thus, we investigated the role of FTO-dependent demethylation in RB and its underlying mechanisms. The biological behavior of RB cells was analyzed using cell counting kit-8, colony formation analysis, transwell assay, flow cytometry, and western
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Systematical identification of key genes and regulatory genetic variants associated with prognosis of esophageal squamous cell carcinoma Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-21 Linglong Gu, Xinying Yue, Siyuan Niu, Jialing Ma, Shasha Liu, Miaoxin Pan, Lina Song, Qianqian Su, Yuqian Tan, Yueping Li, Jiang Chang
Esophageal squamous cell carcinoma (ESCC) stands as a highly lethal malignancy characterized by pronounced recurrence and metastasis, resulting in a bleak 5‐year survival rate. Despite extensive investigations, encompassing genome‐wide association studies, the identification of robust prognostic markers has remained elusive. In this study, leveraging four independent data sets comprising 404 ESCC patients
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RhoGDIβ inhibition via miR-200c/AUF1/SOX2/miR-137 axis contributed to lncRNA MEG3 downregulation-mediated malignant transformation of human bronchial epithelial cells Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-20 Yichao Yang, Zhongxian Tian, Lijiong He, Hao Meng, Xiaomin Xie, Ziyi Yang, Xinxing Wang, Yunping Zhao, Chuanshu Huang
Nickel pollution is a recognized factor contributing to lung cancer. Understanding the molecular mechanisms of its carcinogenic effects is crucial for lung cancer prevention and treatment. Our previous research identified the downregulation of a long noncoding RNA, maternally expressed gene 3 (MEG3), as a key factor in transforming human bronchial epithelial cells (HBECs) into malignant cells following
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Targeting TAOK1 with resveratrol inhibits esophageal squamous cell carcinoma growth in vitro and in vivo Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-20 Mengqiu Song, Yingzi Qu, Huajie Jia, Yunqing Zhang, Shihui Liu, Kyle Vaughn Laster, Bu Young Choi, Jie Tian, Tingxuan Gu, Hanyong Chen, Kangdong Liu, Mee-Hyun Lee, Zigang Dong
The worldwide incidence and mortality rates of esophageal squamous cell carcinoma (ESCC) have increased over the last decade. Moreover, molecular targets that may benefit the therapeutics of patients with ESCC have not been fully characterized. Our study discovered that thousand and one amino-acid protein kinase 1 (TAOK1) is highly expressed in ESCC tumor tissues and cell lines. Knock-down of TAOK1
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Tissue-of-origin for cancers determines HIF-1 activation induced phenotypic heterogeneity Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-19 Shaofei Liu, Yamin Liu, Xihua Qiu, Yasir Suhail, Kshitiz
Hypoxia-inducible factor-1 (HIF-1) is the master regulator of cellular response to hypoxia, and is activated in many cancers contributing to many steps in the metastatic cascade by acting as a key transcription co-regulator for a large number of downstream genes. Presence of hypoxia within a tumor is spatially nonuniform, and can also by dynamic. Further, although HIF-1 is primarily stabilized and
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EMX2 inhibits clear cell renal cell carcinoma progress via modulating Akt/FOXO3a pathway Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-16 Xiaofeng Zhou, Sicheng Dong, Yuhao Zhou, Zhiqing He, Zhixiong Zhang, Liqiong Liao, Bangyu Zou, Xiaopeng Zheng, Kaoqing Peng, Xiaolu Duan
Empty spiracles homeobox 2 (EMX2) is initially identified as a key transcription factor that plays an essential role in the regulation of neuronal development and some brain disorders. Recently, several studies emphasized that EMX2 could as a tumor suppressor, but its role in human clear cell renal cell carcinoma (ccRCC) remains unclear. In the present study, we investigated the role and underlying
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Comprehensive analysis of m6A methylome and transcriptome by Nanopore sequencing in clear cell renal carcinoma Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-16 Hexin Li, Chang Li, Yuxiang Zhang, Weixing Jiang, Fubo Zhang, Xiaokun Tang, Gaoyuan Sun, Siyuan Xu, Xin Dong, Jianzhong Shou, Yong Yang, Meng Chen
N6-methyladenosine (m6A) is the most prevalent epigenetic modification on eukaryotic messenger RNAs. Recent studies have focused on elucidating the key role of m6A modification patterns in tumor progression. However, the relationship between m6A and transcriptional regulation remains elusive. Nanopore technology enables the quantification of m6A levels at each genomic site. In this study, a pair of
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Peptidase inhibitor 16 promotes proliferation of pancreatic ductal adenocarcinoma cells through OASL signaling Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-14 Qun Chen, Lu-Yang Jiang, Cheng Cao, Feng-Yuan Liu, Dan-Rui Li, Peng-Fei Wu, Kui-Rong Jiang
Pancreatic ductal adenocarcinoma (PDAC) is a highly invasive cancer with a poor prognosis and a 5-year survival rate of less than 11%. As a member of the CAP superfamily of proteins, the role of peptidase inhibitor 16 (Pi16) in tumor progression is still unclear. Immunohistochemistry and quantitative RT-PCR methods were used to detect the expression levels of Pi16 protein and mRNA in PDAC patients
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KDM5B promotes metastasis and epithelial–mesenchymal transition via Wnt/β-catenin pathway in squamous cell carcinoma of the head and neck Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-14 Wenhui Yuan, Junli Hu, Mengshu Wang, Guo Li, Shanhong Lu, Yuanzheng Qiu, Chao Liu, Yong Liu
Metastasis determines clinical management decision and restricts the therapeutic efficiency in patients with squamous cell carcinoma of the head and neck (SCCHN). Epigenetic factor KDM5B serves as an oncogene in multiple cancers. However, its role in SCCHN metastasis remains unclear. Our previous study showed that KDM5B is significantly elevated in SCCHN tissue and is positively correlated with metastasis
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HNRNPC promotes estrogen receptor-positive breast cancer cell cycle by stabilizing WDR77 mRNA in an m6A-dependent manner Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-14 Wenjie Xu, Ziwei Huang, Yunxiao Xiao, Wenhui Li, Ming Xu, Qiuyang Zhao, Pengfei Yi
Breast cancer has become the most commonly diagnosed cancer. Heterogeneous nuclear ribonucleoprotein C (HNRNPC), a reader of N6-methyladenosine (m6A), has been observed to be upregulated in various types of cancer. Nevertheless, the role of HNRNPC in breast cancer and whether it is regulated by m6A modification deserve further investigation. The expression of HNRNPC in breast cancer was examined by
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Glutaminase potentiates the glycolysis in esophageal squamous cell carcinoma by interacting with PDK1 Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-14 Guangzhao Zhu, Fangxia Guan, Shenglei Li, Qing Zhang, Xueying Zhang, Yue Qin, Zhangzhan Sun, Shaohua Peng, Jiexing Cheng, Yiyang Li, Ruili Ren, Tianli Fan, Hongtao Liu
Increasing evidence has demonstrated that glutaminase (GLS) as a key mitochondrial enzyme plays a pivotal role in glutaminolysis, which widely participates in glutamine metabolism serving as main energy sources and building blocks for tumor growth. However, the roles and molecular mechanisms of GLS in esophageal squamous cell carcinoma (ESCC) remains unknown. Here, we found that GLS was highly expressed
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Neuronal CFL1 upregulation in head and neck squamous cell carcinoma enhances tumor-nerve crosstalk and promotes tumor growth Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-14 Ruoyan Liu, Chunli Wang, Zhonghao Sun, Xiaotian Shi, Ze Zhang, Jingtao Luo
Head and neck squamous cell carcinoma (HNSCC) is a prevalent cancer type, marked by a pronounced nerve density within the tumor microenvironment and a high rate of perineural invasion (PNI). Growing evidence suggests that the nervous system plays a vital role in HNSCC progression. Yet, the mechanisms governing cancer-nerve interactions remain largely elusive. Our research revealed that cofilin-1 (CFL1)
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Prenatal arsenic exposure alters keratinocyte stem cell fate through persistent activation of IGF2R-MAPK cascade leading to aggravated skin carcinogenesis in mice offspring Mol. Carcinog. (IF 4.6) Pub Date : 2024-02-01 Anchal Chauhan, Siddhartha Gangopadhyay, Vineeta Sharma, Sukhveer Singh, Kavita Koshta, Dhirendra Singh, Kausar M. Ansari, Vikas Srivastava
Chronic exposure to arsenic (As) promotes skin carcinogenesis in humans and potentially disturbs resident stem cell dynamics, particularly during maternal and early life exposure. In the present study, we demonstrate how only prenatal arsenic exposure disturbs keratinocyte stem cell (KSC) conditioning using a BALB/c mice model. Prenatal As exposure alters the normal stemness (CD34, KRT5), differentiation
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Liensinine inhibits progression of intrahepatic cholangiocarcinoma by regulating TGF-β1 /P-smad3 signaling through HIF-1a Mol. Carcinog. (IF 4.6) Pub Date : 2024-01-30 Xuewen Zhu, Wenming Bao, Xiaozai Xie, Bo Chen, Rizhao Li, Jungang Zhao, Lijun Wu, Zhengping Yu, Shi Li, Qiandong Zhu, Gang Chen, Jiacheng Li
Intrahepatic cholangiocarcinoma (ICC) is a high-grade malignant digestive system tumor with an insidious onset and unfavorable prognosis. Liensinine, a small molecule derived from plants, has been proven to have significant tumor suppressor activity in other cancers. However, there are no reports on whether liensinine can inhibit the proliferation or metastasis of ICC. This study aimed to explore the
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NT5DC2 knockdown suppresses progression, glycolysis, and neuropathic pain in triple-negative breast cancer by blocking the EGFR pathway Mol. Carcinog. (IF 4.6) Pub Date : 2024-01-30 Rui Sang, Xiaoping Yu, Han Xia, Xingxing Qian, Jiacheng Yong, Yan Xu, Yan Sun, Yiran Yao, Jing Zhou, Shuangshuang Zhuo
Triple-negative breast cancer (TNBC) is an exceptionally aggressive breast cancer subtype associated with neuropathic pain. This study explores the effects of 5′-nucleotidase domain-containing protein 2 (NT5DC2) on the progression of TNBC and neuropathic pain. Microarray analysis was conducted to identify differentially expressed genes in TNBC and the pathways involved. Gain- and loss-of-function assays
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Silencing lncRNA-DARS-AS1 suppresses nonsmall cell lung cancer progression by stimulating miR-302a-3p to inhibit ACAT1 expression Mol. Carcinog. (IF 4.6) Pub Date : 2024-01-30 Ji Li, Yizhuo Li, Xiaodan Sun, Lai Wei, Jingqian Guan, Lin Fu, Jiang Du, Xiupeng Zhang, Ming Cheng, Huan Ma, Siyu Jiang, Qianqian Zheng, Liang Wang
Long noncoding RNAs (LncRNAs) have been gaining attention as potential therapeutic targets for lung cancer. In this study, we investigated the expression and biological behavior of lncRNA DARS-AS1, its predicted interacting partner miR-302a-3p, and ACAT1 in nonsmall cell lung cancer (NSCLC). The transcript level of DARS-AS1, miR-302a-3p, and ACAT1 was analyzed using qRT-PCR. Endogenous expression of
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SN-38, an active metabolite of irinotecan, inhibits transcription of nuclear factor erythroid 2-related factor 2 and enhances drug sensitivity of colorectal cancer cells Mol. Carcinog. (IF 4.6) Pub Date : 2024-01-25 Jingya Wang, Jiangli Xu, Shuhui Yang, Liu He, Wenhuai Xu, Yan'e Liu, Baoshan Cao, Siwang Yu
Nuclear factor erythroid 2-related factor 2 (Nrf2) significantly contributes to drug resistance of cancer cells, and Nrf2 inhibitors have been vigorously pursued. Repurposing of existing drugs, especially anticancer drugs, is a straightforward and promising strategy to find clinically available Nrf2 inhibitors and effective drug combinations. Topoisomerase inhibitors SN-38 (an active metabolite of
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SSBP1 is a novel prognostic marker and promotes disease progression via p38MAPK signaling pathway in multiple myeloma Mol. Carcinog. (IF 4.6) Pub Date : 2024-01-23 Pingping Xiao, Jizhen Wang, Tingting Li, Apeng Yang, Dongbiao Qiu, Junmin Chen, Zhiyong Zeng
Multiple myeloma (MM) remains an incurable disease. Identification of meaningful co-expressed gene clusters or representative biomarkers of MM may help to identify new pathological mechanisms and promote the development of new therapies. Here, we performed weighted sgene co-expression network analysis and a series of bioinformatics analysis to identify single stranded DNA binding protein 1 (SSBP1)
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Breast cancer malignancy is governed by regulation of the macroH2A2/TM4SF1 axis, the AKT/NF-κB pathway, and elevated MMP13 expression Mol. Carcinog. (IF 4.6) Pub Date : 2024-01-22 Yunho Jin, Da-Young Eum, Chaeyoung Lee, Soon Yong Park, Jae Woong Shim, Yoo Jin Choi, Si Ho Choi, Joong-Gook Kim, Kyu Heo, Seong-Joon Park
The histone variant, macroH2A (mH2A) influences gene expression through epigenetic regulation. Tumor suppressive function of mH2A isoforms has been reported in various cancer types, but few studies have investigated the functional role of mH2A2 in breast cancer pathophysiology. This study aimed to determine the significance of mH2A2 in breast cancer development and progression by exploring its downstream
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circRNA TATA-box binding protein associated factor 15 acts as an oncogene to facilitate bladder cancer progression through targeting miR-502-5p/high mobility group box 3 Mol. Carcinog. (IF 4.6) Pub Date : 2024-01-16 Hong Yang, Peilin He, Wei Luo, Shaoyou Liu, Yong Yang
Circular RNAs (circRNAs) are key in regulating bladder cancer progression. This study explored the effects of circRNA TATA-box binding protein associated factor 15 (circTAF15) on bladder cancer progression. We enrolled 80 bladder cancer patients to examine the relationship between circTAF15 expression and clinical features. The function of circTAF15 on bladder cancer cell viability, proliferation,
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The FOXO1/G6PC axis promotes gastric cancer progression and mediates 5-fluorouracil resistance by targeting the PI3K/AKT/mTOR signaling pathway Mol. Carcinog. (IF 4.6) Pub Date : 2024-01-15 Anna Han, Taorui Liu, Pan Du, Mengying Wang, Jiajing Liu, Liyan Chen
Gastric cancer (GC) is a prevalent malignancy of the digestive system. Distant metastasis and chemotherapy resistance are the crucial obstacles to prognosis in GC. Recent research has discovered that the glucose-6-phosphatase catalytic subunit (G6PC) plays an important role in tumor malignant development. However, little evidence has highlighted its role in GC. Herein, through a comprehensive analysis
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ABHD6 suppresses colorectal cancer progression via AKT signaling pathway Mol. Carcinog. (IF 4.6) Pub Date : 2024-01-10 Xiaoyu Xiong, Changjiang Yang, Yiteng Jin, Rui Zhang, Shuo Wang, Lin Gan, Sen Hou, Yudi Bao, Zexian Zeng, Yingjiang Ye, Zhidong Gao
Colorectal cancer (CRC) continues to be a prevalent malignancy, posing a significant risk to human health. The involvement of alpha/beta hydrolase domain 6 (ABHD6), a serine hydrolase family member, in CRC development was suggested by our analysis of clinical data. However, the role of ABHD6 in CRC remains unclear. This study seeks to elucidate the clinical relevance, biological function, and potential
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Cancer-associated fibroblasts promote stemness maintenance and gemcitabine resistance via HIF-1α/miR-21 axis under hypoxic conditions in pancreatic cancer Mol. Carcinog. (IF 4.6) Pub Date : 2024-01-10 Keping Deng, Fang Zou, Jin Xu, Dayong Xu, Zhen Luo
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BST2 promotes gastric cancer metastasis under the regulation of HOXD9 and PABPC1 Mol. Carcinog. (IF 4.6) Pub Date : 2024-01-10 Jiaying Li, Ping Yang, Linjie Hong, Wushuang Xiao, Luyu Zhang, Zhen Yu, Jieming Zhang, Miaomiao Pei, Ying Peng, Xiangyang Wei, Xiaosheng Wu, Weimei Tang, Yingying Zhao, Juanying Yang, Zhizhao Lin, Ping Jiang, Li Xiang, Hui Zhang, Jianjiao Lin, Jide Wang
Gastric cancer (GC) constitutes substantial cancer mortality worldwide. Several cancer types aberrantly express bone marrow stromal cell antigen 2 (BST2), yet its functional and underlying mechanisms in GC progression remain unknown. In our study, RNA sequencing data revealed that BST2 was transcriptionally activated by homeobox D9 (HOXD9). BST2 was significantly upregulated in GC tissues and promoted
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Nicotinamide mononucleotide induces autophagy and ferroptosis via AMPK/mTOR pathway in hepatocellular carcinoma Mol. Carcinog. (IF 4.6) Pub Date : 2024-01-10 Zhanbo Sun, Lixian Liu, Hongyuan Liang, Lingyun Zhang
Hepatocellular carcinoma (HCC) is a common malignancy worldwide. Herein, we investigated the role of nicotinamide mononucleotide (NMN) in HCC progression. HCC cells were treated with NMN (125, 250, and 500 μM), and then nicotinamide adenine dinucleotide (NAD+) and NADH levels in HCC cells were measured to calculate NAD+/NADH ratio. Cell proliferation, apoptosis, autophagy and ferroptosis were determined
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Novel two-tiered screening approach identifies synergistic combinations of natural compounds for prostate cancer prevention and treatment Mol. Carcinog. (IF 4.6) Pub Date : 2024-01-10 Chelsea A. Friedman, Achinto Saha, G. Lavender Hackman, Xiyuan Lu, Alessia Lodi, Stefano Tiziani, John DiGiovanni
Prostate cancer (PCa) is the second most common cancer type among American men and it is estimated that in 2023, 34,700 men will die from PCa. Since it can take a considerable amount of time for the disease to progress to clinically evident cancer, there is ample opportunity for effective chemopreventive strategies to be applied for the successful management of PCa progression. In the current study
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ITGA7 loss drives the differentiation of adipose-derived mesenchymal stem cells to cancer-associated fibroblasts Mol. Carcinog. (IF 4.6) Pub Date : 2024-01-04 Xiaoli Liu, Rui Gao, Qiulei Wu, Guoqing Li, Xiaohan Xu, Wenhan Li, Pan Liu, Xiaoman Wang, Jing Cai, Min Li, Zehua Wang
Cancer-associated fibroblasts (CAFs) represent a major cellular component of the tumor (pre-)metastatic niche and play an essential role in omental dissemination of ovarian cancer. The omentum is rich in adipose, and adipose-derived mesenchymal stem cells (ADSCs) have been identified as a source of CAFs. However, the molecular events driving the phenotype shift of ADSCs remain largely unexplored. In
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Knockout of Shcbp1 sensitizes immunotherapy by regulating α-SMA positive cancer-associated fibroblasts Mol. Carcinog. (IF 4.6) Pub Date : 2024-01-03 Qianlin Gu, Zhijian Ma, Qiaoyan Wang, Yiwei Dai, Wengui Shi, Zuoyi Jiao
The crucial role of cancer-associated fibroblasts (CAFs) in promoting T-cell exclusion has a significant impact on tumor immune evasion and resistance to immunotherapy. Therefore, enhancing T-cell infiltration into solid tumors has emerged as a pivotal area of research. We achieved a conventional knockout of Shcbp1 (Shcbp1−/−) through CRISPR/Cas9 gene editing and crossed these mice with spontaneous
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Identification of concurrent STAT3::RARA and RARA::STAT5b fusions in a variant APL case Mol. Carcinog. (IF 4.6) Pub Date : 2023-12-28 Tingting Tao, Jiannong Cen, Chao Xu, Yan Chen, Yanglin Cao, Yanlei Gong, Mingqing Zhu, Suning Chen, Qike Zhang, Li Yao
Acute promyelocytic leukemia (APL) with typically PML::RARA fusion gene caused by t (15;17) (q22; q12) was distinguished from other types of acute myeloid leukemia. In a subset of patients with APL, t (15;17) (q22;q21) and PML::RARA fusion cannot be detected. In this report, we identified the coexistence of STAT3::RARA and RARA::STAT5b fusions for the first time in a variant APL patient lacking t
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Venetoclax overcomes resistance to all-trans retinoic acid in a variant acute promyelocytic leukemia with TNRC18::RARA fusion Mol. Carcinog. (IF 4.6) Pub Date : 2023-12-22 Jing Xu, He Li, Zhongwang Wang, Mengyao Wang, Qian Li, Xiaohang Hang, Juan Xu, Jie Ji, Chong Chen, Yu Liu, Ting Niu
Acute promyelocytic leukemia (APL) is generally driven by PML::RARA, but approximately 2% of variant APL patients do not contain this fusion gene and pose challenges in diagnosis and treatment. Here, we reported an aggressive APL patient with variant TNRC18::RARA fusion gene, who was resistant to standard differentiation induction therapy consisting of all-trans retinoic acid (ATRA) and arsenic trioxide but