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Sitravatinib combined with PD1 blockade enhances cytotoxic T-Cell infiltration by M2 to M1 tumor macrophage repolarization in esophageal adenocarcinoma. Carcinogenesis (IF 4.7) Pub Date : 2023-11-29 Ryan Sweeney,Ashten N Omstead,John T Fitzpatrick,Ping Zheng,Anastasia Gorbunova,Erin E Grayhack,Arul Goel,Alisha F Khan,Juliann E Kosovec,Patrick L Wagner,Blair A Jobe,Ronan J Kelly,Ali H Zaidi
Esophageal adenocarcinoma (EAC) is a leading cause of cancer-related mortality. Sitravatinib is a novel multi-gene tyrosine kinase inhibitor (TKI) that targets tumor-associated macrophage (TAM) receptors, VEGF, PDGF, and c-Kit. Currently, sitravatinib is actively being studied in clinical trials across solid tumors and other TKIs have shown efficacy in combination with immune checkpoint inhibitors
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Actinomycin D Synergizes with Doxorubicin in Triple-Negative Breast Cancer by Inducing P53-Dependent Cell Apoptosis. Carcinogenesis (IF 4.7) Pub Date : 2023-11-24 Hong Yang,Sha Li,Wan Li,Yihui Yang,Yizhi Zhang,Sen Zhang,Yue Hao,Wanxin Cao,Fang Xu,Hongquan Wang,Guanhua Du,Jinhua Wang
BACKGROUND There are three major subtypes of breast cancer, ER+, HER2+ and triple-negative breast cancer (TNBC), namely ER-, PR-, HER2-. TNBC is the most aggressive breast cancer with poor prognosis and no target drug up to now. Actinomycin D (ActD) is a bioactive metabolite of marine bacteria that has been reported to have antitumor activity. METHODS To investigate whether ActD has a synergetic effect
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ALDH2 dysfunction and alcohol cooperate in cancer stem cell enrichment. Carcinogenesis (IF 4.7) Pub Date : 2023-11-18 Samuel Flashner,Masataka Shimonosono,Yasuto Tomita,Norihiro Matsuura,Shinya Ohashi,Manabu Muto,Andres J Klein-Szanto,J Alan Diehl,Che-Hong Chen,Daria Mochly-Rosen,Kenneth I Weinberg,Hiroshi Nakagawa
The alcohol metabolite acetaldehyde is a potent human carcinogen linked to esophageal squamous cell carcinoma (ESCC) initiation and development. Aldehyde dehydrogenase 2 (ALDH2) is the primary enzyme that detoxifies acetaldehyde in the mitochondria. Acetaldehyde accumulation causes genotoxic stress in cells expressing the dysfunctional ALDH2E487K dominant negative mutant protein linked to ALDH2*2,
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miR-1304 targets KLK11 to regulate gastric cancer cell proliferation through the mTOR signaling pathway. Carcinogenesis (IF 4.7) Pub Date : 2023-11-16 Yi Ding,Zehua Wang,Chen Chen,Dongyu Li,Wenjia Wang,Yongxu Jia,Yanru Qin
Gastric cancer (GC) is prevalent worldwide but has a dismal prognosis, and its molecular and pathogenic pathways remain unknown. Kallikrein 11 has a reduced expression in gastric cancer and may be a promising biomarker. Herein, the function of KLK11 in GC and its regulatory mechanism was studied. Gene sequencing and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) were used to
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Splicing factor ESRP1 derived circ_0068162 promotes the progression of Oral squamous cell carcinoma via the miR-186/JAG axis. Carcinogenesis (IF 4.7) Pub Date : 2023-11-15 Shuai Chen,Yingrui Zong,Zhenzhen Hou,Zhifen Deng,Zongping Xia
BACKGROUND Oral squamous cell carcinoma (OSCC) is a common malignancy in the oral and maxillofacial regions with an increasing incidence rate. Circular RNA (circRNA) is a recently discovered long-chain noncoding RNA family member. The objective of this study was to analyze the role of circ_0068162 in OSCC development. METHODS We downloaded sample data GSE145608 from the Gene Expression Omnibus database
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CircCDK17 promotes the proliferation and metastasis of ovarian cancer cells by sponging miR-22-3p to regulate CD147 expression. Carcinogenesis (IF 4.7) Pub Date : 2023-11-11 Bin Qu,Lisha Sun,Ping Xiao,Haoming Shen,Yuxi Ren,Jing Zhang
Ovarian cancer (OC) is a common malignancy in women of reproductive age. Circular RNAs (circRNAs) are emerging players in OC progression. We investigated the function and mechanism of circular RNA hsa_circ_0027803 (circCDK17) in OC pathogenesis. RT-qPCR and western blot were utilized for gene and protein expression analysis, respectively. CCK-8, EdU and Transwell assays investigated OC cell proliferation
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Long noncoding RNA NRAV in the 12q24.31 risk locus drives gastric cancer development through glucose metabolism reprogramming. Carcinogenesis (IF 4.7) Pub Date : 2023-11-09 Yan Zhang,Yun Gao,Fengyuan Li,Qi Qi,Qian Li,Yuanliang Gu,Zhonghua Zheng,Beiping Hu,Tianpei Wang,Erbao Zhang,Hao Xu,Li Liu,Tian Tian,Guangfu Jin,Caiwang Yan
Long noncoding RNAs (lncRNAs) serve as vital candidates to mediate cancer risk. Here, we aimed to identify the risk single nucleotide polymorphisms (SNPs)-induced lncRNAs and to investigate their roles in gastric cancer (GC) development. Through integrating the differential expression analysis of lncRNAs in GC tissues and expression quantitative trait loci (eQTL) analysis in normal stomach tissues
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Multi-Omics Analysis Revealed The Regulation Mode of Intratumor Microorganisms And Microbial Signatures in Gastrointestinal Cancer. Carcinogenesis (IF 4.7) Pub Date : 2023-11-07 Siqi Wang,Pei Liu,Jie Yu,Tongxiang Liu
Gastrointestinal cancer is one of the most common malignant tumors in the world, and its incidence rate is always high. In recent years, research has shown that microorganisms may play a broad role in the diagnosis, pathogenesis, and treatment of cancer. In this study, samples were first classified according to the microbial expression data of Gastrointestinal cancer, followed by functional enrichment
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LncRNA CCAT1 participates in pancreatic ductal adenocarcinoma progression by forming a positive feedback loop with c-Myc. Carcinogenesis (IF 4.7) Pub Date : 2023-11-04 Chundong Cheng,Zonglin Liu,Danxi Liu,Hua Chen,Yongwei Wang,Bei Sun
Long noncoding RNAs (lncRNAs) play fundamental roles in cancer development; however, the underlying mechanisms for a large proportion of lncRNAs in pancreatic ductal adenocarcinoma (PDAC) have not been elucidated. The expression of colon cancer associated transcript-1 (CCAT1) in PDAC specimens and cell lines was measured by quantitative real-time PCR (qRT-PCR). The function of CCAT1 was examined in
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Aqueous Extracts of Ocimum gratissimum Mitigate Colitis and Protect Against AOM/DSS-Induced Colorectal Cancer in Mice. Carcinogenesis (IF 4.7) Pub Date : 2023-10-21 Jer-Yuh Liu,Fang-Ling Tsai,Ya-Ling Chuang,Je-Chiuan Ye
In this study, we explored the in vivo effects of Ocimum gratissimum aqueous extracts (OGE) on colorectal cancer (CRC) development provoked by azoxymethane/dextran sodium sulfate (AOM/DSS). The results showed a significant reduction in the tumor load and tumor number for the OGEH group that received continued administration of OGE compared to the AOM/DSS group, with p-values of <0.01, but this was
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miR-22 promotes immunosuppression via activating JAK/STAT3 signaling in cutaneous squamous cell carcinoma. Carcinogenesis (IF 4.7) Pub Date : 2023-10-20 Shukai Yuan,Tong Zhu,Jianan Wang,Ruoyu Jiang,Aofeng Shu,Zhenlei Zhang,Peitao Zhang,Xuequan Feng,Li Zhao
Immunotherapy is the only approved systemic therapy for advanced cutaneous squamous cell carcinoma (cSCC), however, roughly 50% of patients do not respond to the therapy and resistance often occurs over time to those who initially respond. Immunosuppression could have a critical role in developing treatment resistance, thus, understanding the mechanisms of how immunosuppression is developed and regulated
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Lnc-PKNOX1-1 inhibits tumor progression in cutaneous malignant melanoma by regulating NF-κB/IL-8 axis. Carcinogenesis (IF 4.7) Pub Date : 2023-10-16 Anlan Hong,Meng Cao,Dongqing Li,Yixin Wang,Guoqiang Zhang,Fang Fang,Liang Zhao,Qiang Wang,Tong Lin,Yan Wang
Cutaneous malignant melanoma is one of the most lethal cutaneous malignancies. Accumulating evidence has demonstrated the potential influence of lncRNAs in biological behaviors of melanoma. Herein, we reported a novel lncRNA, lnc-PKNOX1-1, and systematically studied its functions and possible molecular mechanisms in melanoma. RT-qPCR assay showed that lnc-PKNOX1-1 was significantly decreased in melanoma
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KCNN1 promotes proliferation and metastasis of breast cancer via ERLIN2-mediated stabilization and K63-dependent ubiquitination of Cyclin B1. Carcinogenesis (IF 4.7) Pub Date : 2023-10-13 Bin Xiao,Qin Xiang,Zihua Deng,Daxiang Chen,Shunhong Wu,Yanxia Zhang,Yaru Liang,Shi Wei,Guoqing Luo,Linhai Li
KCNN1, an integral membrane protein, is thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. However, the role of KCNN1 in tumorigenesis has been rarely reported, and the underlying molecular mechanism remains unclear. Here, we report that KCNN1 functions as an oncogene in promoting breast cancer cell proliferation and metastasis. KCNN1
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Interplay between inflammasomes and PD-1/PD-L1 and their implications in cancer immunotherapy. Carcinogenesis (IF 4.7) Pub Date : 2023-10-05 Zhong-Yu Jiao,Jun Zhang
The inflammasomes play crucial roles in inflammation and cancer development, while the PD-1/PD-L1 pathway is critical for immune suppression in the tumor microenvironment (TME). Recent research indicates a reciprocal regulatory relationship between inflammasomes and PD-1/PD-L1 signaling in cancer development and PD-1 blockade treatment. By activating in diverse cells in tumor tissues, inflammasome
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Emerging evidence on the role of breast microbiota on the development of breast cancer in high-risk patients. Carcinogenesis (IF 4.7) Pub Date : 2023-10-04 Silvia Actis,Massimiliano Cazzaniga,Valentina Elisabetta Bounous,Marta D'Alonzo,Roberta Rosso,Francesca Accomasso,Carola Minella,Nicoletta Biglia
Cancer is a multi-factorial disease, and the etiology of breast cancer is due to a combination of both genetic and environmental factors. Breast tissue shows a unique microbiota, Proteobacteria and Firmicutes are the most abundant bacteria in breast tissue, and several studies have shown that the microbiota of healthy breast differs from that of breast cancer. Breast microbiota appears to be correlated
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Construction and identification of lncRNA/circRNA coregulated ceRNA networks in gemcitabine-resistant bladder carcinoma. Carcinogenesis (IF 4.7) Pub Date : 2023-10-03 Jingjing Pan,Xiaojuan Xie,Jinxiu Sheng,Chenxi Ju,Shuaijie Sun,Fangfang Cui,Wen Zhai,Liang Ming
To explore the regulatory networks that underlie the development of chemoresistance in bladder cancer, we analyzed profiles of differentially expressed lncRNAs, circRNAs, miRNAs and mRNAs in gemcitabine-resistant/sensitive bladder cancer cells using next-generation sequencing data. Hundreds of differentially expressed lncRNAs and miRNAs and thousands of circRNAs and mRNAs were identified. Bioinformatics
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Splicing transcriptome-wide association study to identify splicing events for pancreatic cancer risk. Carcinogenesis (IF 4.7) Pub Date : 2023-09-28 Duo Liu,Ye Eun Bae,Jingjing Zhu,Zichen Zhang,Yanfa Sun,Youping Deng,Chong Wu,Lang Wu
A large proportion of the heritability of pancreatic cancer risk remains elusive, and the contribution of specific mRNA splicing events to pancreatic cancer susceptibility has not been systematically evaluated. In this study, we performed a large splicing transcriptome-wide association study (spTWAS) using three modeling strategies (Enet, LASSO, and MCP) to develop alternative splicing genetic prediction
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m6A-modified circASXL1 promotes proliferation and migration of ovarian cancer through the miR-320d/RACGAP1 axis. Carcinogenesis (IF 4.7) Pub Date : 2023-09-22 Qi Tian,Qingling Mu,Shuang Liu,Kui Huang,Yi Tang,Pu Zhang,Jing Zhao,Chuqiang Shu
Ovarian cancer (OC) is one of the most common malignant tumors in women. Circular RNAs (circRNAs) can potentially regulate the development of OC. Therefore, this study investigated the role of circASXL1 in OC progression. Cell functions were assessed by MTT, colony formation, wound healing and transwell assays. RIP and dual luciferase reporter assays confirmed the relationship between miR-320d and
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Association between new plasma inflammatory markers and risk of colorectal neoplasms in individuals over 50 years old. Carcinogenesis (IF 4.7) Pub Date : 2023-09-15 Jia-Yi Su,Yun Wang,Shang-Shang Wu,Wen-Kun Li,Cheng-Yao Wang,Jiu-Yue Ma,Yu-Ting Qiu,Min-Si Zhou,Zhan Wang,Peng Li,Chun-Tao Liu,Jing Wu
Recently, several studies have explored inflammatory biomarkers associated with colorectal neoplasms in human plasma and investigated the prognostic value of systemic cytokine profiles and inflammatory markers in colorectal cancer. However, little is known about inflammatory biomarkers in colorectal adenoma and early cancer. We compared the level of 38 inflammatory markers in the plasma of 112 adenoma
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Prognostic microRNA signature for estimating survival in patients with hepatocellular carcinoma. Carcinogenesis (IF 4.7) Pub Date : 2023-09-13 Srinivasulu Yerukala Sathipati,Nikhila Aimalla,Ming-Ju Tsai,Tonia Carter,Sohyun Jeong,Zhi Wen,Sanjay K Shukla,Rohit Sharma,Shinn-Ying Ho
Hepatocellular carcinoma (HCC) is one of the leading cancer types with increasing annual incidence and high mortality in the United States. MicroRNAs (miRNAs) have emerged as valuable prognostic indicators in cancer patients. To identify a miRNA signature predictive of survival in patients with HCC, we developed a machine learning-based HCC survival estimation method, HCCse, using the miRNA expression
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α5-nAChR/STAT3/CD47 axis contributed to nicotine-related lung adenocarcinoma progression and immune escape. Carcinogenesis (IF 4.7) Pub Date : 2023-09-08 Guiyu Kang,Yang Jiao,Pan Pan,Huiping Fan,Qiang Li,Xiangying Li,Jingtan Li,Yan Wang,Yanfei Jia,Jingting Wang,Haiji Sun,Xiaoli Ma
The CHRNΑ5 gene, which encodes the α5-nicotinic acetylcholine receptor (α5-nAChR), is related to lung cancer and nicotine addiction. Smoking is closely related to the immunosuppressive effect of macrophages. CD47, a phagocytosis checkpoint in macrophages, is a therapeutic target in various cancer types. Nevertheless, the relationship between α5-nAChR and CD47 in lung cancer is still unclear. The present
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A scan of all coding region variants of the human genome, identifies 13q12.2-rs9579139 and 15q24.1-rs2277598 as novel risk loci for pancreatic ductal adenocarcinoma. Carcinogenesis (IF 4.7) Pub Date : 2023-09-06 Matteo Giaccherini,Leonardo Gori,Manuel Gentiluomo,Riccardo Farinella,Klara Cervena,Jurgita Skieceviciene,Frederike Dijk,Gabriele Capurso,Antonis Vezakis,Livia Archibugi,Roger Chammas,Tamás Hussein,Francesca Tavano,Péter Hegyi,Martin Lovecek,Jakob Izbicki,Hermann Brenner,Beatrice Mohelnikova-Duchonova,Giuseppe Dell'Anna,Juozas Kupcinskas,Stefano Ermini,Mateus Nóbrega Aoki,John P Neoptolemos,Maria Gazouli
Coding sequence variants comprise a small fraction of the germline genetic variability of the human genome. However, they often cause deleterious change in protein function and are therefore associated with pathogenic phenotypes. To identify novel pancreatic ductal adenocarcinoma (PDAC) risk loci, we carried out a complete scan of all common missense and synonymous SNPs and analysed them in a case
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SOCS1 acts as a ferroptosis driver to inhibit the progression and chemotherapy resistance of triple-negative breast cancer. Carcinogenesis (IF 4.7) Pub Date : 2023-09-04 Yiding Wang,Xiaoling Pang,Yuexin Liu,Guiling Mu,Qian Wang
INTRODUCTION Ferroptosis is involved in many types of cancers, including triple-negative breast cancer (TNBC). Suppressor of cytokine signaling 1 (SOCS1) has recently been implicated as a regulator of ferroptosis. We aim to explore whether targeting SOCS1 is a potential therapeutic strategy for TNBC therapy. METHODS Stable cell lines were constructed using lentivirus transfection. Cell viability was
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Construction and testing of a risk prediction classifier for cardia carcinoma. Carcinogenesis (IF 4.7) Pub Date : 2023-08-25 Zhiqiang Liu,Ganshu Xia,Xiaolong Liang,Shoumiao Li,Yanxin Gong,Baozhong Li,Jingyu Deng
OBJECTIVE This research aimed to construct a prediction model for stages Ⅱ and Ⅲ cardia carcinoma (CC), and provide an effective preoperative evaluation tool for clinicians. METHODS CC mRNA expression matrix was obtained from Gene Expression Omnibus and The Cancer Genome Atlas databases. Non-negative matrix factorization was used to cluster data to obtain subgroup information, and weighted gene co-expression
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Cancer-associated fibroblasts promote cancer stemness by inducing expression of the chromatin-modifying protein CBX4 in squamous cell carcinoma. Carcinogenesis (IF 4.7) Pub Date : 2023-08-18 Matthew L Fisher,Seamus Balinth,Yon Hwangbo,Caizhi Wu,Carlos Ballon,Gary L Goldberg,Alea A Mills
The chromobox-containing protein CBX4 is an important regulator of epithelial cell proliferation and differentiation, and has been implicated in several cancer types. The cancer stem cell (CSC) population is a key driver of metastasis and recurrence. The undifferentiated, plastic state characteristic of CSCs relies on cues from the microenvironment. Cancer-associated fibroblasts (CAFs) are a major
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Dual roles of cellular communication network factor 6 (CCN6) in the invasion and metastasis of oral cancer cells to bone via binding to BMP2 and RANKL. Carcinogenesis (IF 4.7) Pub Date : 2023-08-17 Hiroaki Hochi,Satoshi Kubota,Masaharu Takigawa,Takashi Nishida
The acquisition of motility via epithelial-mesenchymal transition (EMT) and osteoclast induction are essential for the invasion and metastasis of oral squamous cell carcinoma (OSCC) to bone. However, the molecule suppressing both EMT and osteoclastogenesis is still unknown. In this study, we found that cellular communication network factor 6 (CCN6) was less produced in a human OSCC cell line, HSC-3
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On the road to colorectal cancer development: crosstalk between the gut microbiota, metabolic reprogramming and epigenetic modifications. Carcinogenesis (IF 4.7) Pub Date : 2023-08-16 Anqi Chen,Zhengting Jiang,Lingli Cai,Dong Tang
An increasing number of studies have reported the role of gut microbes in colorectal cancer (CRC) development, as they can be influenced by dietary metabolism and mediate alterations in host epigenetics, ultimately affecting CRC. Intake of specific dietary components can affect gut microbial composition and function, and their metabolism regulates important epigenetic functions that may influence CRC
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Exposure to smoky coal combustion emissions and leukocyte Alu retroelement copy number. Carcinogenesis (IF 4.7) Pub Date : 2023-08-10 Batel Blechter,Jason Y Y Wong,Wei Hu,Richard Cawthon,George S Downward,Lützen Portengen,Yongliang Zhang,Bofu Ning,Mohammad L Rahman,Bu-Tian Ji,Jihua Li,Kaiyun Yang,H Dean Hosgood,Debra T Silverman,Yunchao Huang,Nathaniel Rothman,Roel Vermeulen,Qing Lan
Household air pollution (HAP) from indoor combustion of solid fuel is a global health burden that has been linked to multiple diseases including lung cancer. In Xuanwei, China, lung cancer rate for non-smoking women is among the highest in the world and largely attributed to high levels of polycyclic aromatic hydrocarbons (PAHs) that are produced from combustion of smoky (bituminous) coal. Alu retroelements
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MALAT1 regulates network of microRNA-15a/16-VEGFA to promote tumorigenesis and angiogenesis in multiple myeloma. Carcinogenesis (IF 4.7) Pub Date : 2023-08-07 Han Yan,Su Gao,Aoshuang Xu,Liping Zuo,Jiasi Zhang,Yuhong Zhao,Qianwen Cheng,Xuejiao Yin,Chunyan Sun,Yu Hu
MALAT1 is one of the most hopeful members implicated in angiogenesis in a variety of non-malignant diseases. In multiple myeloma (MM), MALAT1 is recognized as the most highly expressed lncRNA. However, the functional roles of MALAT1 in angiogenesis and the responsible mechanisms have not yet been explored. Herein, we discovered a novel regulatory network dependent on MALAT1 in relation to MM tumorigenesis
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PABPN1 promotes clear cell renal cell carcinoma progression by suppressing the alternative polyadenylation of SGPL1 and CREG1. Carcinogenesis (IF 4.7) Pub Date : 2023-10-20 Ming Xiong,Chunyu Liu,Wencheng Li,Huiling Jiang,Wulin Long,Menghao Zhou,Chenlu Yang,Gallina Kazobinka,Yi Sun,Jun Zhao,Teng Hou
Alternative polyadenylation (APA) is an important post-transcriptional regulatory mechanism in cancer development and progression. Poly(A) binding protein nuclear 1 (PABPN1) is a gene that encodes abundant nuclear protein, binds with high affinity to nascent poly(A) tails, and is crucial for 3'-UTR (3'-untranslated region) APA. Although PABPN1 has been recently reported as a dominant master APA regulator
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The current landscape of therapies for hepatocellular carcinoma. Carcinogenesis (IF 4.7) Pub Date : 2023-10-20 Kelley Coffman-D'Annibale,Changqing Xie,Donna M Hrones,Shadin Ghabra,Tim F Greten,Cecilia Monge
Globally, primary liver cancer is the third leading cause of cancer-related deaths, with approximately 830 000 deaths worldwide in 2020, accounting for 8.3% of total deaths from all cancer types (1). This disease disproportionately affects those in countries with low or medium Human Development Index scores in Eastern Asia, South-Eastern Asia, and Northern and Western Africa (2). Hepatocellular carcinoma
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RNA sequencing reveals the implication of the circRNA-associated ceRNA network in oesophageal squamous cell carcinoma. Carcinogenesis (IF 4.7) Pub Date : 2023-10-20 Suli Dai,Cong Zhang,Xiaojian Wei,Xiaohan Wang,Yang Wen,Feng Gao,Lianmei Zhao,Baoen Shan
Circular RNAs (circRNAs) have attracted increasing attention in cancer research. However, there are few studies about the high-throughput sequencing for clinical cohorts focussing on the expression characteristics and regulatory networks of circRNAs in oesophageal squamous cell carcinoma (ESCC) until now. Present study aim to comprehensively recognize the functional and mechanistic patterns of circRNA
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Exosome-transmitted miR-29a induces colorectal cancer metastasis by destroying the vascular endothelial barrier. Carcinogenesis (IF 4.7) Pub Date : 2023-06-24 Keshu Liu,Rongzhang Dou,Chaogang Yang,Ziyang Di,Dongdong Shi,Chunxiao Zhang,Jialin Song,Yan Fang,Sihao Huang,Zhenxian Xiang,Weisong Zhang,Shuyi Wang,Bin Xiong
Metastasis is the leading cause of colorectal cancer treatment failure and mortality. Communication between endothelium and tumor cells in the tumor microenvironment is required for cancer metastasis. Tumor-derived exosomes have been shown to increase vascular permeability by delivering microRNA (miRNA) to vascular endothelial cells, facilitating cancer metastasis. The mechanism by which Epithelial-mesenchymal
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Depletion of Gr1+ myeloid cells attenuates high-fat-diet-aggravated esophageal squamous cell carcinoma in mice. Carcinogenesis (IF 4.7) Pub Date : 2023-10-20 Peng Jianmin,Hu Qinchao,Wang Chunyang,Zhang Jiayu,Wang Siyu,Wang Li,Xia Juan,Cheng Bin
Obesity is a leading cause of multiple cancers, but whether it promotes esophageal squamous cell carcinoma (ESCC) and its underlying cancer-promoting mechanism remains unclear. To evaluate the effect of a high-fat diet (HFD) on ESCC and explore the role and mechanism of myeloid-derived suppressor cells (MDSCs) in HFD-induced ESCC, C57BL/6J mice were treated with 4-nitroquinoline 1-oxide (4NQO) to induce
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Smoking and risk of colorectal cancer according to KRAS and BRAF mutation status in a Japanese prospective Study. Carcinogenesis (IF 4.7) Pub Date : 2023-08-18 Shiori Nakano,Taiki Yamaji,Kouya Shiraishi,Akihisa Hidaka,Taichi Shimazu,Aya Kuchiba,Masahiro Saito,Fumihito Kunishima,Ryouji Nakaza,Takashi Kohno,Norie Sawada,Manami Inoue,Shoichiro Tsugane,Motoki Iwasaki
Although smoking is a major modifiable risk factor for many types of cancer, evidence for colorectal cancer is equivocal in Asian populations. Recent Western studies have proposed that the association between smoking and colorectal cancer is restricted to specific tumor molecular subtypes. However, no studies have evaluated the association according to tumor molecular subtypes in Asian populations
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Pan-cancer analysis of G6PD carcinogenesis in human tumors. Carcinogenesis (IF 4.7) Pub Date : 2023-08-18 Bin Liu,Xiaoli Fu,Yuhui Du,Zichen Feng,Ruiqin Chen,Xiaoxue Liu,Fangfang Yu,Guoyu Zhou,Yue Ba
Glucose-6-phosphate dehydrogenase (G6PD) is involved in the catalytic pentose phosphate pathway (PPP), which is closely related to energy metabolism. G6PD plays a crucial role in many types of cancer, but the specific molecular mechanisms of G6PD in cancer remain unclear. Therefore, we investigated the potential oncogenic role of G6PD in various tumors based on The Cancer Genome Atlas (TCGA), the cBioPortal
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ARHGAP25 suppresses the development of breast cancer by an ARHGAP25/Wnt/ASCL2 feedback loop. Carcinogenesis (IF 4.7) Pub Date : 2023-08-10 Sijia Han,Xueying Jin,Tianyu Hu,Feng Chi
Downregulation of ARHGAP25 was found in the tumor samples from breast cancer patients and five breast cancer cell lines. However, its precise role and molecular mechanisms in breast cancer remain completely unknown. Herein, we found that knockdown of ARHGAP25 in breast cancer cells promoted proliferation, migration and invasion of breast cancer cells. Mechanistically, ARHGAP25 silence facilitated the
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EphB6 deficiency in intestinal neurons promotes tumor growth in colorectal cancer by neurotransmitter GABA signaling. Carcinogenesis (IF 4.7) Pub Date : 2023-06-09 Hao Yu,Xiao-Kang Qin,Kai-Wen Yin,Zi-Ming Li,En-De Ni,Jian-Ming Yang,Xun-Hua Liu,Ai-Jun Zhou,Shu-Ji Li,Tian-Ming Gao,Ying Li,Jian-Ming Li
EphB6 belongs to the receptor tyrosine kinase, whose low expression is associated with shorter survival of colorectal cancer (CRC) patients. But the role and mechanism of EphB6 in the progression of CRC need further study. In addition, EphB6 was mainly expressed in intestinal neurons. But how EphB6 is involved in functions of intestinal neurons has not been known. In our study, we constructed a mouse
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The ubiquitin E3 ligase MDM2 induces chemoresistance in colorectal cancer by degradation of ING3. Carcinogenesis (IF 4.7) Pub Date : 2023-10-20 Liangliang Zhang,Dagang Zhu,Jiwen Jiang,Zhenyu Min,Zhenzhong Fa
Chemoresistance is an obstacle for colorectal cancer (CRC) treatment. This study investigates the role of the ubiquitin E3 ligase MDM2 in affecting cell growth and chemosensitivity in CRC cells by modifying the transcription factor inhibitor of growth protein 3 (ING3). The expression of MDM2 and ING3 in CRC tissues was predicted by bioinformatics analysis, followed by expression validation and their
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Combined Wee1 and EGFR inhibition reveals synergistic antitumor effect in esophageal squamous cell carcinoma. Carcinogenesis (IF 4.7) Pub Date : 2023-08-18 Dongshao Chen,Ruoxi Hong,Youjun Cao,Qingnan Wu,Yan Wang,Jie Chen,Jinting Li,Weimin Zhang,Qimin Zhan
Epidermal growth factor receptor (EGFR) is one of the most common amplified and overexpressed oncogenes in esophageal squamous cell carcinoma (ESCC), while the clinical efficacy of EGFR-targeted therapy in ESCC is dismal. Here, we evaluated the efficacy of dual blockage using monoclonal antibody against EGFR (Nimotuzumab) and an Wee1 inhibitor (AZD1775) in ESCC. We found that the mRNA and protein expression
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CD48 suppresses cell proliferation and migration as a prognostic immune signature in the cervical cancer immune microenvironment. Carcinogenesis (IF 4.7) Pub Date : 2023-06-03 Yue Ma,Zhuo Yang,Jing Liu,Danbo Wang
Cervical cancer (CC) is one of the most common malignant tumors in gynecology. Immunotherapy and targeted therapy are two particularly effective treatments. In this study, weighted gene co-expression network analysis and CIBERSORT algorithm that quantifies the cellular composition of immune cells were used to analyze CC expression data based on the GEO database and identify modules related to CD8 +
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Hypoxia-responsive lncRNA G077640 promotes ESCC tumorigenesis via the H2AX-HIF1α-glycolysis axis. Carcinogenesis (IF 4.7) Pub Date : 2023-08-10 Xiaomei Huang,Chunxia Liu,Hao Li,Tianyang Dai,Gang Luo,Chunxiang Zhang,Tao Li,Muhan Lü
Long noncoding RNAs (lncRNAs) contribute to esophageal squamous cell carcinoma (ESCC) progression, but the underlying mechanisms remain elusive. In this study, we verified a hitherto uncharacterized hypoxia-responsive lncRNA, G077640, which is upregulated in human ESCC cells and tissues, supporting the proliferation and migration of ESCC cells. Mechanistically, G077640 prevented hypoxia-inducible factor-1α
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miR-424-3p promotes metastasis of hepatocellular carcinoma via targeting the SRF-STAT1/2 axis. Carcinogenesis (IF 4.7) Pub Date : 2023-10-20 Lan Feng,Xi Chen,Peiyao Li,Yuanfeng Li,Yun Zhai,Xinyi Liu,Qian Jin,Hongxing Zhang,Chaohui Yu,Baocai Xing,Ying Cui,Pengbo Cao,Gangqiao Zhou
Although emerging evidence has established the roles of miRNAs in hepatocellular carcinoma (HCC), the global functional implication of miRNAs in this malignancy remains largely uncharacterized. Here, we aim to systematically identify novel miRNAs involved in HCC and clarify the function and mechanism of specific novel candidate miRNA(s) in this malignancy. Through an integrative omics approach, we
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Construction of a prognostic model for lung squamous cell carcinoma based on immune-related genes. Carcinogenesis (IF 4.7) Pub Date : 2023-05-26 Jiangtao Pu,Zhangyu Teng,Wenxing Yang,Peiquan Zhu,Tao Zhang,Dengguo Zhang,Biao Wang,Zhi Hu,Qi Song
Lung squamous cell carcinoma (LUSC) lacks appropriate prognostic and diagnostic strategies. Available studies suggest the effectiveness of immunotherapy for LUSC, but effective molecular markers are still insufficient. We obtained mRNA expression and clinical information of LUSC samples from The Cancer Genome Atlas (TCGA) database. Enrichment levels of immune-related genes were revealed by single sample
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O-GlcNAcylation of RAB10 promotes hepatocellular carcinoma progression. Carcinogenesis (IF 4.7) Pub Date : 2023-05-22 Zhuo Lv,Guolu Ma,Zhuo Zhong,Xiong Xie,Bin Li,De Long
Ras-related protein Rab-10 (RAB10) is involved in tumorigenesis and progression of hepatocellular carcinoma (HCC). Here, we found RAB10, O-GlcNAc transferase (OGT), and O-GlcNAcylation were upregulated in HCC. In addition, RAB10 protein level was prominently positively correlated with the expression of OGT. O-GlcNAcylation modification of RAB10 was then investigated. Here we showed that RAB10 interacts
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Genome-wide identification of aberrant alternative splicing and RNA-binding protein regulators in acute myeloid leukaemia which may contribute to immune microenvironment remodelling. Carcinogenesis (IF 4.7) Pub Date : 2023-08-10 Ying Yang,Yu-Mei Zhang,Yan Wang,Kui Liu,Si-Yuan Cui,Ya-Qin Luo,Wei Zheng,Jie Xu,Wei Duan,Jing-Yi Wang
Acute myeloid leukaemia (AML) is one of the most lethal cancers of the haematopoietic system with a poorly understood aetiology. Recent studies have shown that aberrant alternative splicing (AS) and a (RBP) regulators are highly associated with the pathogenesis of AML. This study presents an overview of the abnormal AS and differential expression of RNA-binding proteins (RBPs) in AML and further highlights
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The presence of intratumoral Porphyromonas gingivalis correlates with a previously defined pancreatic adenocarcinoma, immune cell expression phenotype and with tumor resident, adaptive immune receptor features. Carcinogenesis (IF 4.7) Pub Date : 2023-08-10 Jacob C Kinskey,Taha I Huda,Etienne C Gozlan,Jessica U Quach,Juan F Arturo,Andrea Chobrutskiy,Boris I Chobrutskiy,George Blanck
The association between pancreatic adenocarcinoma (PAAD) and the pancreatic microbiome is not fully understood, although bacteria may decrease the effectiveness of chemotherapy and lead to anti-apoptotic, pro-inflammatory microenvironments. To better understand the relationship between the PAAD microbiome and the microenvironment, we identified Porphyromonas gingivalis-positive PAAD samples and found
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CCL18 promotes migration and invasion of multiple myeloma cells and is associated with poor prognosis. Carcinogenesis (IF 4.7) Pub Date : 2023-05-15 Bing Qiao,Lei Chen,Qianwen Cheng,Guangqi Wang,Qun Li,Bo Zhang,Junying Li,Yu Hu,Chunyan Sun
CCL18 has recently been implicated in malignancies and is increasingly mentioned as a potential tumoral biomarker and furtherly a molecular target for therapeutic intervention, but its expression and clinical significance in multiple myeloma have not been explored. Serum CCL18 levels were measured by ELISA method in 254 newly diagnosed multiple myeloma (NDMM), 21 monoclonal gammopathy of undetermined
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PPM1G promotes the progression of lung adenocarcinoma by inhibiting p38 activation via dephosphorylation of MEK6. Carcinogenesis (IF 4.7) Pub Date : 2023-05-15 Jingying Chen,Jizhuo Li,Hong Sun,Tianyi Hu,Yameng Wang,Guoqi Kang,Mingya Cao,Xia Li
The p38 MAP kinase (MAPK) signaling pathway is a key signal transduction cascade that cancer cells employ to sense and adapt to a plethora of environmental stimuli and has attracted much attention as a promising target for cancer therapy. Although the kinases that phosphorylate p38 have been extensively studied, the negative regulation of p38 phosphorylation remains to be elucidated. Here, we found
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METTL9 derived circular RNA circ-METTL9 sponges miR-551b-5p to accelerate colorectal cancer progression by upregulating CDK6. Carcinogenesis (IF 4.7) Pub Date : 2023-08-18 Ming Li,Zheng Zhi,Xuan Jiang,Guo-Cai Duan,Wei-Na Zhu,Zheng Pang,Lian Wang,Rui Ge,Xin Dai,Jia-Meng Liu,Ting-Yue Chen,Jin-Jing Jia,Jian-Ming Li,Li-Na Sun
Circular RNAs (circRNAs) have been accepted to play key roles in the development and progression of mutiple cancers including colorectal cancer (CRC). Here, we identified circ-METTL9, derived from 2 to 4 exons of METTL9 gene, may promote CRC progression by accelerating cell cycle progression. However, the role and mechanism of circ-METTL9 in CRC remains unclear. Based on our data, the expression of
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Solamargine enhanced gefitinib antitumor effect via regulating MALAT1/miR-141-3p/Sp1/IGFBP1 signaling pathway in non-small cell lung cancer. Carcinogenesis (IF 4.7) Pub Date : 2023-08-18 Qing Tang,Qichun Zhou,Jing Li,Xiaobing Yang,Rui Wang,Xi Wang,Mengfei Xu,Ling Han,Wanyin Wu,Sumei Wang
Lung cancer is the leading cause of cancer-related deaths worldwide. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) showed great therapeutic efficacy for non-small cell lung cancer (NSCLC) patients. However, acquired resistance severely limits the clinical application and efficacy of EGFR-TKIs. In the current study, we found that solamargine (SM), a natural alkaloid derived
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TERT and BRAF V600E mutations in thyroid cancer of World Trade Center Responders. Carcinogenesis (IF 4.7) Pub Date : 2023-06-24 Maaike van Gerwen,Janete Maria Cerutti,Thais Biude Mendes,Rachel Brody,Eric Genden,Gregory J Riggins,Emanuela Taioli
The 2-fold excess thyroid cancer risk reported in multiple World Trade Center (WTC) disaster exposed cohorts cannot entirely be explained by surveillance and physician bias thus highlighting the need to investigate the potential consequences of the dust exposure, containing carcinogenic and endocrine disruptive elements, on the thyroid. This study investigated the presence of TERT promoter and BRAF
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Ginseng mediates its anticancer activity by inhibiting the expression of DNMTs and reactivating methylation-silenced genes in colorectal cancer. Carcinogenesis (IF 4.7) Pub Date : 2023-08-10 Keisuke Okuno,Muhammad Yogi Pratama,Jiang Li,Masanori Tokunaga,Xin Wang,Yusuke Kinugasa,Ajay Goel
Developing safe and effective therapeutic modalities remains a critical challenge for improving the prognosis of patients with colorectal cancer (CRC). In this regard, targeting epigenetic regulation in cancers has recently emerged as a promising therapeutic approach. Since several natural compounds have recently been shown to be important epigenetic modulators, we hypothesized that Ginseng might exert
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Thymoquinone inhibits lung cancer stem cell properties via triggering YAP degradation. Carcinogenesis (IF 4.7) Pub Date : 2023-08-10 Yujiao Zhang,Xizhi Liu,Wenhui Dang,Lu Liu
Due to the characteristics of high recurrence and metastasis, it is still difficult to cure lung cancer. Cancer stem cells (CSCs) are a group of tumor cells with self-renewal ability and differentiation potential, which are responsible for lung cancer recurrence. Therefore, targeting CSCs may provide a new strategy for lung cancer treatment. Thymoquinone (TQ), the main active ingredient isolated from
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The environmental carcinogen benzo[a]pyrene regulates epigenetic reprogramming and metabolic rewiring in a two-stage mouse skin carcinogenesis model. Carcinogenesis (IF 4.7) Pub Date : 2023-08-10 Md Shahid Sarwar,Christina N Ramirez,Hsiao-Chen Dina Kuo,Pochung Chou,Renyi Wu,Davit Sargsyan,Yuqing Yang,Ahmad Shannar,Rebecca Mary Peter,Ran Yin,Yujue Wang,Xiaoyang Su,Ah-Ng Kong
Non-melanoma skin cancer (NMSC) is the most common cancer in the world. Environmental exposure to carcinogens is one of the major causes of NMSC initiation and progression. In the current study, we utilized a two-stage skin carcinogenesis mouse model generated by sequential exposure to cancer-initiating agent benzo[a]pyrene (BaP) and promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA), to study
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MCM6 promotes intrahepatic cholangiocarcinoma progression by upregulating E2F1 and enhancing epithelial-mesenchymal transition. Carcinogenesis (IF 4.7) Pub Date : 2023-06-24 Chongqing Gao,Jing Li,Fuling Zeng,Lijuan Wang,Kaiyun Chen,Dong Chen,Jian Hong,Chen Qu
Minichromosome maintenance complex component 6 (MCM6), a member of the MCM family, plays a pivotal role in DNA replication initiation and genome duplication of proliferating cells. MCM6 is upregulated in multiple malignancies and is considered a novel diagnostic biomarker. However, the functional contributions and prognostic value of MCM6 in intrahepatic cholangiocarcinoma (ICC) remain unexplored.
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Inhibition of lung adenocarcinoma by combinations of sulfasalazine (SAS) and disulfiram-copper (DSF-Cu) in cell line models and mice. Carcinogenesis (IF 4.7) Pub Date : 2023-06-24 Alireza Jian Bagherpoor,Mohammad Shameem,Xianghua Luo,Davis Seelig,Fekadu Kassie
Sulfasalazine (SAS) is a repurposed antitumor drug which inhibits the proliferation and survival of cancer cells by inhibiting the xCT cellular antioxidant system. Recent clinical studies have shown that, due to poor bioavailability, the antitumor effects of SAS monotherapy are minimal. Therefore, we hypothesized that DSF, another repurposed drug that has demonstrated anticancer effects, or its complex
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Cancer-associated fibroblasts-derived exosome-mediated transfer of miR-345-5p promotes the progression of colorectal cancer by targeting CDKN1A. Carcinogenesis (IF 4.7) Pub Date : 2023-06-24 Weikun Shi,Yuxin Liu,Xiaoyuan Qiu,Ling Yang,Guole Lin
Colorectal cancer (CRC) is the second leading cause of cancer-induced death in the world. Cancer-associated fibroblasts (CAFs) released exosomes that contributed to cancer progression. This research was carried out to study the influence of CRC-associated fibroblasts-derived exosomes on the phenotype of CRC cells and the underlying mechanism. CAFs-derived exosomes (CAFs-exo) and normal fibroblasts