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A Novel Intergenic Region (chr2: 30,316,870)-ALK Fusion in a Patient with Lung Adenocarcinoma Responding to Crizotinib Combined with Pemetrexed Treatment: A Case Report OncoTargets Ther. (IF 4.0) Pub Date : 2024-03-27 Danfei Zhou, Jun Ying, Shanshan Hu, Jiangdong Li, Haijian Liu
Background: Anaplastic lymphoma kinase (ALK) rearrangements have been reported as an important oncogenic driver in 5– 7% non-small cell lung cancer (NSCLC) patients. Reports about the intergenic region (IGR) as an ALK fusion partner are rare. In this study, we report a novel IGR (chr2: 30,316,870)-ALK fusion in an advanced lung adenocarcinoma patient that responded effectively to crizotinib combined
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M2-Type Macrophages and Cancer-Associated Fibroblasts Combine to Promote Colorectal Cancer Liver Metastases OncoTargets Ther. (IF 4.0) Pub Date : 2024-03-26 Yunpeng Feng, Shifeng Qiao, Jie Chen, Xin Wen, Yanlei Chen, Xiaoyu Song, Jiaxin Xu, Xiucheng Qiao, Jing Yang, Shenshen Zhang, Yang Feng, Yu Gao
Purpose: This research explored the association between CD163-labeled M2-type macrophages and cancer-associated fibroblasts (CAFs) in the tumor microenvironment (TME) of 38 colorectal cancer (CRC) liver metastases. In addition, we investigated the correlation differences between M2-type macrophages and CAFs in the tumor microenvironments of 38 primary colorectal cancer patients with confirmed liver
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Development and Validation of a Machine Learning-Based Model Used for Predicting Hepatocellular Carcinoma Risk in Patients with Hepatitis B-Related Cirrhosis: A Retrospective Study OncoTargets Ther. (IF 4.0) Pub Date : 2024-03-23 Yixin Hou, Jianguo Yan, Ke Shi, Xiaoli Liu, Fangyuan Gao, Tong Wu, Peipei Meng, Min Zhang, Yuyong Jiang, Xianbo Wang
Object: Our objective was to estimate the 5-year cumulative risk of HCC in patients with HBC by utilizing an artificial neural network (ANN). Methods: We conducted this study with 1589 patients hospitalized at Beijing Ditan Hospital of Capital Medical University and People’s Liberation Army Fifth Medical Center. The training cohort consisted of 913 subjects from Beijing Ditan Hospital of Capital Medical
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Progerin Inhibits the Proliferation and Migration of Melanoma Cells by Regulating the Expression of Paxillin OncoTargets Ther. (IF 4.0) Pub Date : 2024-03-22 Weixian Liu, Xinxian Huang, Weizhao Luo, Xinguang Liu, Weichun Chen
Objective: Progerin, the underlying cause of Hutchinson-Gilford Progeria Syndrome (HGPS), has been extensively studied for its impact on normal cells and premature aging patients. However, there is a lack of research on its specific effects on tumor cells. Melanoma is one of the most common malignant tumors with high morbidity and mortality. This study aimed to elucidate the potential therapeutic role
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Apolipoprotein E is a Potential Biomarker for Predicting Cancer Prognosis and is Correlated with Immune Infiltration OncoTargets Ther. (IF 4.0) Pub Date : 2024-03-19 Jinji Chen, Herong Zhu, Shaohua Chen, Hua Mi
Background: Apolipoprotein E (APOE) is a polymorphic protein that plays a role in lipoprotein transformation and metabolism. It is involved in numerous physiological processes within the body and is closely associated with tumor growth and metastasis. However, the role of APOE in pan-cancer has yet to be evaluated. Therefore, studying the association between APOE and various cancer types is crucial
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Taking the Next Step in Double Refractory Disease: Current and Future Treatment Strategies for Chronic Lymphocytic Leukemia OncoTargets Ther. (IF 4.0) Pub Date : 2024-03-08 Manabu Hayama, John C Riches
Abstract: Chronic lymphocytic leukemia (CLL) is a monoclonal B-cell lymphoproliferative disease with a high annual incidence in Western countries. As B-cell receptor (BCR) signaling and intrinsic apoptotic resistance play critical roles in the development and survival of CLL cells, therapeutic approaches targeting these pathways have been extensively investigated to tackle this incurable disease. Over
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TSC22D2 Regulates ACOT8 to Delay the Malignant Progression of Colorectal Cancer OncoTargets Ther. (IF 4.0) Pub Date : 2024-03-05 Nana Zhou, Chaoqin Guo, Jingyang Du, Xu Zhang, Qiuran Xu, Xiaoliang Zheng, Linglan Tu
Purpose: Colorectal cancer (CRC) is one of the cancers with high incidence and mortality rates worldwide. In China, there are approximately 400,000 new CRC cases each year, seriously endangering people’s life and health. Transforming growth factor β-stimulated clone 22 domain family, member 2 (TSC22D2) is widely expression in cancers, but the role of TSC22D2 in CRC are still unknown. Methods: Real‑time
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Treatment of Abdominal Desmoplastic Small Round Cell Tumor Induces Acute Myeloid Leukemia-M5: A Case Report and Literature Review OncoTargets Ther. (IF 4.0) Pub Date : 2024-02-27 Lan Liu, Meizuo Zhong, Xuan Zhou, Fanhua Kang, Yong Long, Junfeng Li
Abstract: Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive malignancy. Most patients are diagnosed at a late stage with poor prognosis. The treatment usually includes combined intensive chemotherapy, cytoreductive surgery, radiotherapy, and targeted therapy. Due to the low incidence rate and dismal survival, there is currently a lack of case reports on DSRCT with concurrent
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SIRT6 Overexpression Induces Apoptosis of Nasopharyngeal Carcinoma by Inhibiting NF-κB Signaling [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2024-02-24 Lei Ouyang, Liang Yi, Jingkun Li, Shijiang Yi, Shisheng Li, Peng Liu, Xinming Yang
Retraction for the article SIRT6 overexpression induces apoptosis of nasopharyngeal carcinoma by inhibiting NF-κB signaling
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LncRNA HCP5 Promotes Cell Invasion and Migration by Sponging miR-29b-3p in Human Bladder Cancer [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2024-02-23 Cheng Zhao, Yangle Li, Xiheng Hu, Ruizhe Wang, Wei He, Long Wang, Lin Qi, Shiyu Tong
Retraction for the article LncRNA HCP5 Promotes Cell Invasion and Migration by Sponging miR-29b-3p in Human Bladder Cancer
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Applications of Yttrium-90 (90Y) in Hepatocellular Carcinoma OncoTargets Ther. (IF 4.0) Pub Date : 2024-02-23 ZhongHao Jiang, Fan Yang, WanXiang Wang
Abstract: Hepatocellular carcinoma (HCC) is the most common primary liver cancer, affecting millions of people worldwide. Due to the lack of systemic radiation therapy in hepatocellular carcinoma, researchers have been investigating the use of yttrium-90 (90Y) radioembolization for local-regional tumor control since the 1960s. With the development of glass and resin 90Y microspheres and the durable
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The lncRNA LINC01194/miR-486-5p Axis Facilitates Malignancy in Non-Small Cell Lung Cancer via Regulating CDK4 [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2024-02-23 Zhiwei Xing, Zhihua Zhang, Yanjun Gao, Xun Zhang, Xianglong Kong, Jianwu Zhang, Hongzhong Bai
Retraction for the article The lncRNA LINC01194/miR-486-5p Axis Facilitates Malignancy in Non-Small Cell Lung Cancer via Regulating CDK4
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Coronin 3 Promotes the Development of Oncogenic Properties in Glioma Through the Wnt/β-Catenin Signaling Pathway [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2024-02-23 Min Wang, Qi Li, Shengyuan Yu, Zexiang Zhang, Peng Qiu, Yubao Zhang, Wei Yang, Guangming Xu, Tongjiang Xu
Retraction for the article Coronin 3 Promotes the Development of Oncogenic Properties in Glioma Through the Wnt/β-Catenin Signaling Pathway
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Prognostic Factors and Construction of Nomogram Prediction Model of Lung Cancer Patients Using Clinical and Blood Laboratory Parameters OncoTargets Ther. (IF 4.0) Pub Date : 2024-02-21 Yamin Zhang, Wei Wan, Rui Shen, Bohao Zhang, Li Wang, Hongyi Zhang, Xiaoyue Ren, Jie Cui, Jinpeng Liu
Objective: This work aimed to explore the prognostic risk factors of lung cancer (LC) patients and establish a line chart prediction model. Methods: A total of 322 LC patients were taken as the study subjects. They were randomly divided into a training set (n = 202) and a validation set (n = 120). Basic information and laboratory indicators were collected, and the progression-free survival (PFS) and
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MicroRNA-126 Inhibit Viability of Colorectal Cancer Cell by Repressing mTOR Induced Apoptosis and Autophagy [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2024-02-20 Li Wei, Zhanhong Chen, Na Cheng, Xing Li, Jie Chen, Donghao Wu, Min Dong, Xiangyuan Wu
Retraction for the article MicroRNA-126 Inhibit Viability of Colorectal Cancer Cell by Repressing mTOR Induced Apoptosis and Autophagy
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Exosome-Delivered EGFR Induced by Acidic Bile Salts Regulates Macrophage M2 Polarization to Promote Esophageal Adenocarcinoma Cell Proliferation OncoTargets Ther. (IF 4.0) Pub Date : 2024-02-16 Chuangui Chen, Jinsheng Ding, Zhao Ma, Yongjie Xie, Linhua Zhang, Dunwan Zhu
Purpose: Chronic gastroesophageal reflux disease (GERD) causes the abnormal reflux of acid and bile salts, which would induce Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC). EGFR, as one of main components of the exosome, plays an important role in cancer progression. Here, we investigated the role of acidic bile salts (ABS)-induced exosomal EGFR in EAC cell proliferation. Methods: Electronic
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miR-136 Targets MIEN1 and Involves the Metastasis of Colon Cancer by Suppressing Epithelial-to-Mesenchymal Transition [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2024-02-15 Haipeng Ren, Yuanling Qi, Xiaoyan Yin, Jianfeng Gao
Retraction for the article miR-136 targets MIEN1 and involves the metastasis of colon cancer by suppressing epithelial-to-mesenchymal transition
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Mst1-Hippo Pathway Triggers Breast Cancer Apoptosis via Inducing Mitochondrial Fragmentation in a Manner Dependent on JNK–Drp1 Axis [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2024-02-15 Hui Ouyang, Enxiang Zhou, Huan Wang
Retraction for the article Mst1-Hippo pathway triggers breast cancer apoptosis via inducing mitochondrial fragmentation in a manner dependent on JNK–Drp1 axis
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Thyroid Metastases from Triple-Negative Breast Cancer with High PD-L1 Expression – A Rare Presentation OncoTargets Ther. (IF 4.0) Pub Date : 2024-02-14 Wenjuan Meng, Qingxia Guo, Gaoyan Tang, Guiyan Han, Guikai Ma, Qingyun Zhang, Rui Li, Shuzhen Liu, Guohua Yu
Abstract: Thyroid metastases secondary to triple-negative breast cancer are sporadic. Diagnosis usually requires fine needle aspiration biopsy (FNAB) and immunohistochemistry. There are no treatment guidelines for this type of cancer, and to date, reports of chemotherapy combined with immunotherapy in thyroid metastases are very rare. Here, we first report the effectiveness of anti-PD-1 inhibitor in
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miR-182 Promotes Tumor Growth and Increases Chemoresistance of Human Anaplastic Thyroid Cancer by Targeting Tripartite Motif 8 [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2024-02-13 Yao Liu, Bing Zhang, Tiefeng Shi, Huadong Qin
Retraction for the article miR-182 promotes tumor growth and increases chemoresistance of human anaplastic thyroid cancer by targeting tripartite motif 8
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Kanglaite Reverses Multidrug Resistance of HCC by Inducing Apoptosis and Cell Cycle Arrest via PI3K/AKT Pathway [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2024-02-13 Chendong Yang, Aihua Hou, Chunfeng Yu, Lingling Dai, Wen Wang, Kangle Zhang, Hongmin Shao, Jinghua Ma, Wenjuan Xu
Retraction for the article Kanglaite reverses multidrug resistance of HCC by inducing apoptosis and cell cycle arrest via PI3K/AKT pathway
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METTL3/MALAT1/ELAVL1 Axis Promotes Tumor Growth in Ovarian Cancer OncoTargets Ther. (IF 4.0) Pub Date : 2024-02-08 Jian Xiong, Wenqin Lian, Rui Zhao, Kefei Gao
Background: Studies increasingly recognize the role of N6-methyladenosine (m6A) modification in cancer occurrence and development. METTL3 is a core catalytic subunit of m6A-modified methyltransferases complex, but its regulatory mechanism in ovarian cancer (OC) is not clear. Methods: In this study, GEPIA 2.0 database was applied for expression analysis, survival analysis and correlation analysis for
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Response to Savolitinib in a Patient with Advanced Poorly Differentiated Lung Carcinoma Positive for a Novel EML4-MET Gene Fusion OncoTargets Ther. (IF 4.0) Pub Date : 2024-01-30 Ganlu Ouyang, Pei Shu, Yinyin Xue, Feng Luo, Yan Li
Background: Cellular-mesenchymal to epithelial transition factor (c-MET) alterations have significant therapeutic implications in non-small cell lung cancer (NSCLC). Although MET fusion is a rare genomic event, advances in detection technologies have enabled the identification of various MET fusion partner genes. However, standard therapeutic options for MET fusion in NSCLC cases remain undefined.
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Amplifying Curcumin’s Antitumor Potential: A Heat-Driven Approach for Colorectal Cancer Treatment OncoTargets Ther. (IF 4.0) Pub Date : 2024-01-30 Janviere Kabagwira, Ryan N Fuller, Paul A Vallejos, Chase S Sugiono, Vola-Masoandro Andrianarijaona, Jazmine Brianna Chism, Michael P O'Leary, David Caba Molina, William Langridge, Maheswari Senthil, Nathan R Wall
Introduction: Peritoneal metastases from colorectal cancer (CRC) present a significant clinical challenge with poor prognosis, often unresponsive to systemic chemotherapy. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment approach for select patients. The use of curcumin, a natural compound with antitumor properties, in HIPEC is of interest due
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SIM2: Its Prognostic Significance and Oncogenic Role in Endometrial Carcinoma OncoTargets Ther. (IF 4.0) Pub Date : 2024-01-26 Yunfang Wei, Xianlei Zhao, Hong Tang, Jin Ma, Yongfeng Wang, Linxia Li
Background: Endometrial carcinoma ranks as the second most widespread malignancy affecting the reproductive system in females. Effective prognostic biomarkers are required to further improve survival rates for patients. Single-minded homolog 2 (SIM2) is known to participate in neurogenesis as a transcription factor. However, the potential role of SIM2 in endometrial carcinoma remains elusive. Methods:
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Uterine Burkitt Lymphoma with Rare Extranodal Deposits in the Bone, Breast, and Sacral Canal: A Case Report OncoTargets Ther. (IF 4.0) Pub Date : 2024-01-26 Xu-Sheng Liu, Chao Liu, Yi-Jia Chen, Dao-Bing Zeng, Ya-Lan Wang, Zhi-Jun Pei
Abstract: Burkitt lymphoma is a highly invasive non-Hodgkin lymphoma. Sporadic Burkitt’s lymphoma is commonly found in the abdomen. However, Burkitt lymphoma infiltrating the uterus is uncommon in occurrence. We report the results of 18F-FDG PET/CT examination of a 36-year-old woman. The report indicates that in addition to the strong uptake of FDG imaging agent in the uterus, bilateral cervical and
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Mannose Suppresses the Proliferation and Metastasis of Lung Cancer by Targeting the ERK/GSK-3β/β-Catenin/SNAIL Axis [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2024-01-25 Qingsong Luo, Bei Li, Gang Li
Retraction for the article Mannose Suppresses the Proliferation and Metastasis of Lung Cancer by Targeting the ERK/GSK-3β/β-Catenin/SNAIL Axis
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LINC00894 Enhances the Progression of Breast Cancer by Sponging miR-429 to Regulate ZEB1 Expression [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2024-01-26 De-feng Meng, Hua Shao, Chuan-bo Feng
Retraction for the article LINC00894 Enhances the Progression of Breast Cancer by Sponging miR-429 to Regulate ZEB1 Expression
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Long Non-Coding RNA LINC01089 Enhances the Development of Gastric Cancer by Sponging miR-145-5p to Mediate SOX9 Expression [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2024-01-26 Fengyong Wang, Qiong Yang
Retraction for the article Long Non-Coding RNA LINC01089 Enhances the Development of Gastric Cancer by Sponging miR-145-5p to Mediate SOX9 Expression
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Metformin Suppresses the Proliferation and Promotes the Apoptosis of Colon Cancer Cells Through Inhibiting the Expression of Long Noncoding RNA-UCA1 [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2024-01-26 Jianbo Guo, Yan Li, He Duan, Lu Yuan
Retraction for the article Metformin Suppresses the Proliferation and Promotes the Apoptosis of Colon Cancer Cells Through Inhibiting the Expression of Long Noncoding RNA-UCA1
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Clinical Response of Advanced Lung Adenocarcinoma with Class III BRAF G466V Missense Mutation to Dabrafenib and Trametinib: A Case Report OncoTargets Ther. (IF 4.0) Pub Date : 2024-01-23 Ruoxin Fang, Sha Xu, Jun Gong, Zhengkai Liao
Aim: BRAF is a pivotal driver gene in cancer development. Based on this, the combination of dabrafenib and trametinib was approved for treating NSCLC patients with BRAFV600E mutations. However, the majority of BRAF mutations in lung cancer are non-V600E variants, particularly class III mutants, which currently lack targeted therapeutic options and result in unfavorable clinical outcomes. Case Presentation:
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Crosstalk Between circRNA and Tumor Microenvironment of Hepatocellular Carcinoma: Mechanism, Function and Applications OncoTargets Ther. (IF 4.0) Pub Date : 2024-01-22 Chenxi Xie, Xiaopei Hao, Hao Yuan, Chongyu Wang, Razinah Sharif, Haibo Yu
Abstract: Hepatocellular carcinoma (HCC) is one of the most common aggressive tumors in the world. Despite the availability of various treatments, its prognosis remains poor due to the lack of specific diagnostic indicators and the high heterogeneity of HCC cases. CircRNAs are noncoding RNAs with stable and highly specific expression. Extensive research evidence suggests that circRNAs mediate the pathogenesis
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UPF1 Participates in the Progression of Endometrial Cancer by Inhibiting the Expression of lncRNA PVT1 [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2024-01-19 Tian-rong Xing, Ping Chen, Jia-mei Wu, Li-li Gao, Wei Yang, Yu Cheng, Li-bo Tong
Retraction for the article UPF1 Participates in the Progression of Endometrial Cancer by Inhibiting the Expression of lncRNA PVT1
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LEF1-AS1, a Long Non-Coding RNA, Promotes Malignancy in Glioblastoma [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2024-01-19 Jin Wang, Xiaoyang Liu, Changsheng Yan, Jie Liu, Songtao Wang, Yongzhi Hong, Aihua Gu, Peng Zhao
Retraction for the article LEF1-AS1, a long non-coding RNA, promotes malignancy in glioblastoma
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Licorice (Glycyrrhiza Glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects [Corrigendum] OncoTargets Ther. (IF 4.0) Pub Date : 2024-01-17 Hardeep Singh Tuli, Vivek Kumar Garg, Jinit K Mehta, Ginpreet Kaur, Ranjan K Mohapatra, Kuldeep Dhama, Katrin Sak, Ajay Kumar, Mehmet Varol, Diwakar Aggarwal, Uttpal Anand, Jagjit Kaur, Ross Gillan, Gautam Sethi, Anupam Bishayee
Corrigendum for the article Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
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The LINC01260 Functions as a Tumor Suppressor via the miR-562/CYLD/NF-κB Pathway in Non-Small Cell Lung Cancer [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2023-12-24 Yangming Chen, Yujie Lei, Jianbin Lin, Yunchao Huang, Jiguang Zhang, Kai Chen, Shihui Sun, Xing Lin
Retraction for the article The LINC01260 Functions as a Tumor Suppressor via the miR-562/CYLD/NF-κB Pathway in Non-Small Cell Lung Cancer
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Inhibition of ATM with KU-55933 Sensitizes Endometrial Cancer Cell Lines to Olaparib OncoTargets Ther. (IF 4.0) Pub Date : 2023-12-19 Anqing Zhang, Liqin Zhang, Xia Xie, Dan Liu
Background: Endometrial cancer (EC) is one of the most prevalent gynecologic cancers, which poses a serious threat to women’s health worldwide. Olaparib, the first FDA-approved PARP inhibitor for the treatment of BRCA-mutated breast, ovarian and pancreatic cancers, triggers apoptosis of cancer cells through synthetic lethality by inhibiting PARP1/2 enzymatic activity and BRCA1/2-dependent homologous
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Post-HSCT Maintenance Treatment Using Entrectinib for an AML Patient Accompanied with ETV6::NTRK3: A Case Report OncoTargets Ther. (IF 4.0) Pub Date : 2023-12-18 Xiaoli Zhao, Mengze Hao, Xiaoyu Zhang, Jialin Wei, Sizhou Feng, Yi He, Erlie Jiang, Mingzhe Han
Abstract: The neurotrophic receptor tyrosine kinase (NTRK) gene fusions occur in a large number of solid tumors and tropomyosin receptor kinase (TRK) inhibitors exhibit attractive antitumor activity. However, the occurrence of NTRK fusions is rare in hematological malignancies, and just a few cases or pre-clinical researches have been reported. This case report presents a refractory acute myeloid leukemia
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ST6GAL2 Downregulation Inhibits Cell Adhesion and Invasion and is Associated with Improved Patient Survival in Breast Cancer [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2023-12-15 Junchi Cheng, Rong Wang, Guansheng Zhong, Xi Chen, Yun Cheng, Wei Li, Yunshan Yang
Retraction for the article ST6GAL2 Downregulation Inhibits Cell Adhesion and Invasion and is Associated with Improved Patient Survival in Breast Cancer
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MLPH Accelerates the Epithelial–Mesenchymal Transition in Prostate Cancer [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2023-12-15 Tianbiao Zhang, Yangyang Sun, Tao Zheng, Rui Wang, Donghui Jia, Weixing Zhang
Retraction for the article MLPH Accelerates the Epithelial–Mesenchymal Transition in Prostate Cancer
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Epithelioid Subtype Gastrointestinal Stromal Tumors of Stomach in an Endoscopic Biopsy: A Potential Diagnostic Pitfall OncoTargets Ther. (IF 4.0) Pub Date : 2023-12-12 Wenfeng Xu, Hao Tang, Ying Chen, Jiashuang Wang, Zhongjiao Chen, Yujuan Xu, Deyu Guo
Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract with a broad morphological spectrum. Although epithelioid GISTs account for 20% of GISTs, their morphological features may pose a diagnostic pitfall for pathologists due to their morphological similarities to poorly differentiated adenocarcinoma and lymphoma. Case Presentation: Herein
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Investigating the Diagnostic and Therapeutic Potential of SREBF2-Related Lipid Metabolism Genes in Colon Cancer OncoTargets Ther. (IF 4.0) Pub Date : 2023-12-11 Yuteng Ma, Zhe Wang, Jian Sun, Jingtong Tang, Jianping Zhou, Ming Dong
Purpose: Colon cancer is one of the leading causes of death worldwide, and screening of effective molecular markers for the diagnosis is prioritised for prevention and treatment. This study aimed to investigate the diagnostic and predictive potential of genes related to the lipid metabolism pathway, regulated by a protein called sterol-regulatory element-binding transcription Factor 2 (SREBF2), for
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miR-188-5p Promotes Tumor Growth by Targeting CD2AP Through PI3K/AKT/mTOR Signaling in Children with Acute Promyelocytic Leukemia [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2023-12-07 Dao Wang, Jiao Chen, Yanjie Ding, Huimin Kong, Hongliang You, Yanting Zhao, Huixia Wei, Yufeng Liu
Retraction for the article miR-188-5p Promotes Tumor Growth by Targeting CD2AP Through PI3K/AKT/mTOR Signaling in Children with Acute Promyelocytic Leukemia
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MicroRNA-503 Inhibits Non-Small Cell Lung Cancer Progression by Targeting PDK1/PI3K/AKT Pathway [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2023-12-07 Yingying Wei, Yuanfan Liao, Yu Deng, Yukun Zu, Bo Zhao, Fan Li
Retraction for the article MicroRNA-503 Inhibits Non-Small Cell Lung Cancer Progression By Targeting PDK1/PI3K/AKT Pathway
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Hsa_circ_0008945 Promoted Breast Cancer Progression by Targeting miR-338-3p [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2023-12-01 Li Zhang, Fengping Ding
Retraction for the article Hsa_circ_0008945 promoted breast cancer progression by targeting miR-338-3p
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Sustained Clinical Response to 4th-Line Therapy with Selpercatinib in RET Fusion-Positive Combined Small Cell Lung Cancer OncoTargets Ther. (IF 4.0) Pub Date : 2023-11-29 Yan Huang, Shuang Dai, Wenlian Yin, Feng Luo, Yan Li
Objective: Combined small cell lung cancer (C-SCLC) is a relatively rare subtype of small cell lung cancer (SCLC) which combines SCLC and any component of non-small cell carcinoma (NSCLC). Patients diagnosed with C-SCLC are currently recommended to receive the same treatment as SCLC cases in the absence of clear evidence suggesting different strategies. The genomic profiling of C-SCLC is rarely studied
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LncRNA FTX Promotes Proliferation and Invasion of Gastric Cancer via miR-144/ZFX Axis [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2023-11-28 Hongbo Li, Guoliang Yao, Jingming Zhai, Dingwen Hu, Yonggang Fan
Retraction for the article LncRNA FTX Promotes Proliferation and Invasion of Gastric Cancer via miR-144/ZFX Axis
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Optimizing the Continuum of Care in Gastric Cancer OncoTargets Ther. (IF 4.0) Pub Date : 2023-11-23 Beatrice Riccò, Giulio Martinelli, Camilla Bardasi, Massimo Dominici, Andrea Spallanzani, Massimiliano Salati
Abstract: Gastric cancer (GC) still ranks as the fifth most common malignancy and the fourth leading cause of cancer-related death worldwide. Despite the recent progress in the therapeutic algorithm of the advanced disease with the advent of immune checkpoint inhibitors (ICIs) and next-generation HER2-directed therapies, survival rates remain poor, with a median survival hardly exceeding 12 months
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Anti-Glioma Effects of Ligustilide or n-Butylphthalide on Their Own and the Synergistic Effects with Temozolomide via PI3K/Akt Signaling Pathway OncoTargets Ther. (IF 4.0) Pub Date : 2023-11-22 Zi-Qi Li, Guo-Song Zhang, Ri-Qun Liu, Shu-Yuan Shuai, Peng-Yi Hu, Qin Zheng, Shu-Hua Xiao
Background: Ligustilide (LIG) and n-butylphthalide (NBP) have neuroprotective effects in cerebral ischemia; however, their roles in gliomas are not well-known.This study aimed to explore the anti-glioma effects of LIG and NBP individually and the synergistic effects of temozolomide (TMZ) via the PI3K/Akt Signaling Pathway. Materials and Methods: Cytotoxicity of LIG and NBP alone and in combination
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Cancer and the Vasopressin Gene: Radioimmunoassay Values and Commentary on Copeptin as a Plasma Marker OncoTargets Ther. (IF 4.0) Pub Date : 2023-11-20 William G North
Background: Vasopressin gene expression has been demonstrated to be a common feature of all small-cell lung cancer (SCLC) and breast cancer. Provasopressin (ProVP) is a component of the cancer cell membrane and a likely target for treatment. However, a measurable fraction of this cancer provasopressin is also normally processed and products are released into the circulation. Vasopressin (VP) and v
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Oral Anlotinib Maintenance Therapy for an Advanced Malignant Peritoneal Mesothelioma Diagnosed by Laparoscopy After Initial Misdiagnosis to Obtain Longer Progression-Free Survival: Case Report and Literature Review OncoTargets Ther. (IF 4.0) Pub Date : 2023-11-15 Fan-Jie Qu, Yi Zhou, Hai Wang
Abstract: Malignant peritoneal mesothelioma (MPeM) is a rare and highly invasive malignant tumor with a lack of specificity in clinical manifestations, which can easily lead to misdiagnosis and missed diagnosis. Due to the difficulty of early diagnosis, most patients are already in the advanced stage when diagnosed, and the prognosis is poor. At present, there is no standard treatment strategy, and
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Predictive Significance of Systemic Immune-Inflammation Index in Patients with Breast Cancer: A Retrospective Cohort Study OncoTargets Ther. (IF 4.0) Pub Date : 2023-11-16 Yunxiang Zhou, Xianan Guo, Lu Shen, Kexin Liu, Qunan Sun, Yali Wang, Hui Wang, Wenyu Fu, Yihan Yao, Shijie Wu, Huihui Chen, Jili Qiu, Tao Pan, Yongchuan Deng
Background: Peripheral blood inflammation indices, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII), have become research hotspots in the diagnosis, treatment, and prognosis prediction of breast cancer, whereas existing research findings remain controversial. Methods: Data pertaining to 1808 breast cancer patients were
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miR-765 Acts as a Tumor Promoter and Indicates Poor Prognosis in Non-Small Cell Lung Cancer [Retraction] OncoTargets Ther. (IF 4.0) Pub Date : 2023-11-10 Jiying Wang, Li Wang, Congjun Zhang
Retraction for the article miR-765 Acts as a Tumor Promoter and Indicates Poor Prognosis in Non-Small Cell Lung Cancer
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Safety and Efficacy Analysis of PD-1 Inhibitors in Combination with Gemcitabine Plus Nab-Paclitaxel for Advanced Pancreatic Cancer: A Real-World, Single-Center Study OncoTargets Ther. (IF 4.0) Pub Date : 2023-11-09 Zhitao Chen, Yahui He, Chenchen Ding, Jun Chen, Yangjun Gu, Min Xiao, Qiyong Li
Background: Pancreatic cancer is a deadly disease with a low five years survival rate, and chemotherapy remains the standard treatment for advanced cases. However, the efficacy of chemotherapy alone is limited, and there is a need for new treatment options. Recently, immune checkpoint inhibitors (ICIs), particularly programmed death-1 (PD-1) inhibitors, have shown promising results in various cancers
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GW4869 Can Inhibit Epithelial-Mesenchymal Transition and Extracellular HSP90α in Gefitinib-Sensitive NSCLC Cells OncoTargets Ther. (IF 4.0) Pub Date : 2023-11-08 Xuan Wan, Yuting Fang, Jiangzhou Du, Shaoxi Cai, Hangming Dong
Objective: GW4869 is an exosomal inhibitor. It is necessary to delay the occurrence of gefitinib resistance during non-small-cell lung cancer (NSCLC) treatment. This study aimed to investigate the anti-tumor effects of GW4869 on epithelial-mesenchymal transition (EMT) and expression of extracellular heat shock protein 90α (eHSP90α) that contributes to acquired resisitance. Our study provides a new
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Successful Treatment of Concurrent Follicular Lymphoma and Triple-Negative Breast Cancer Using Rituximab Plus Nab-Paclitaxel and Cisplatin: A Case Report and Literature Review OncoTargets Ther. (IF 4.0) Pub Date : 2023-11-01 Zhou Zhu, Na Zhou, Shuangni Yu, Xin Gao, Xin Cheng, Yingyi Wang, Chunmei Bai
Background: Co-occurrence of breast cancer and non-Hodgkin’s lymphoma is a rare condition with diagnostic and therapeutic challenges. The coexistence of follicular lymphoma (FL) and triple-negative breast cancer (TNBC) has not been described previously. Case Presentation: A 46-year-old woman, already suffering a history of untreated, advanced-stage, high tumor burden FL, was admitted for a rapidly
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Galectin-9 Expression is Correlated to Cervical Squamous Cell Carcinoma Progression and Overall Survival OncoTargets Ther. (IF 4.0) Pub Date : 2023-10-31 Victoriano Mendieta-Carmona, Guadalupe Delgado-López, Julio Reyes-Leyva, Claudia Teresita Gutiérrez-Quiroz, Víctor Javier Vazquez-Zamora, Denisse Alejandra Picazo-Mendoza, Alvaro José Montiel-Jarquín, Laura Patricia Martinez-Morales, Verónica Vallejo-Ruiz
Purpose: To determine whether galectin-9 gene (LGALS9) expression is correlated with cervical cancer progression, clinicopathological characteristics, and overall survival. To determine the biological processes and the abundance of tumour infiltrating immune cells related to the expression of LGALS9. Patients and Methods: The study was conducted in two phases: 1) The expression level of LGALS9 was
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Immunotherapy Combined with Chemotherapy in Relapse Metaplastic Breast Cancer OncoTargets Ther. (IF 4.0) Pub Date : 2023-10-30 Ling Chen, Zhe Meng, Zhiguo Zhou, Xiaomin Li, Liyan Zhao, Zhaohui Jia, Jingli Chen, Ye Tian, Qingju Meng, Yibing Liu
Abstract: Metaplastic breast cancer (MBC) is a rare disease, and there was rarely reported the treatment after recurrence and metastasis. Here, we report the treatment of an adult patient who suffered from MBC with lung, lymph nodes and left pleura metastasis after radical surgery. The next-generation sequencing result demonstrated that it had tumor mutational burden (TMB) of 12.0 Muts/Mb and microsatellite
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B7 Induces Apoptosis in Colorectal Cancer Cells by Regulating the Expression of Caspase-3 and Inhibits Autophagy OncoTargets Ther. (IF 4.0) Pub Date : 2023-10-27 Xinyi Zhang, Fengxi Li, Rong Li, Nan Zhao, Dianfeng Liu, Yuelin Xu, Lei Wang, Dongxu Wang, Ruihong Zhao
Purpose: Heterocyclic compounds are organic compounds with heterocyclic structures, which are common in drug molecules. They include pyrazines with diverse functions, including anti-cancer, antimicrobial, antidiabetic, and anticholinergic activities. In this study a new small molecular compound B7 based on tetrazolium substituted pyrazine was synthesized and its effect on the progression of colorectal
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HOXC Cluster Antisense RNA 3, a Novel Long Non-Coding RNA as an Oncological Biomarker and Therapeutic Target in Human Malignancies OncoTargets Ther. (IF 4.0) Pub Date : 2023-10-24 Yunhe Xie, Jiarong Ye, Hongliang Luo
Abstract: HOXC cluster antisense RNA 3 (HOXC-AS3) is a novel long noncoding RNA (lncRNA) that exhibits aberrant expression patterns in various cancer types. Its expression is closely related to clinicopathological features, demonstrating significant clinical relevance across multiple tumors. And HOXC-AS3 plays multifaceted roles in tumor progression, impacting cell proliferation, apoptosis, migration