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Treatment of elderly patients with head and neck cancer in an aging society: Focus on geriatric assessment and surgical treatment Auris Nasus Larynx (IF 1.7) Pub Date : 2024-04-16 Ryo Ishii, Akira Ohkoshi, Yukio Katori
Previous studies of the treatment of elderly head and neck cancer (HNC) patients were very limited and sometimes controversial. Although conclusions differ across various reports, it is often concluded that advanced chronological age does not directly affect prognosis, but that comorbidities and declines in physical and cognitive functions promote the occurrence of adverse events, especially with surgical
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A Nationwide survey of safety protocols and chemosensory assessments by Japanese clinicians pre- and post-COVID-19 pandemic Auris Nasus Larynx (IF 1.7) Pub Date : 2024-04-15 Ayaho Yoshino, Ryosuke Murakami, Kei Hosoya, Taro Komachi, Eri Mori, Tomomi Nin, Mehmet K. Mahmut, Kimihiro Okubo
There has been an increase of attention and awareness of smell and taste loss due to the impact of COVID-19. However, little is known about the influence of COVID-19 on the number of psychophysical tests performed, the timing of these tests, or the protection protocols employed to protect against virus transmission. A survey was distributed to 404 institutes of the Oto-Rhino Laryngological Society
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Sinonasal manifestations of granulomatosis with polyangiitis: A retrospective analysis Auris Nasus Larynx (IF 1.7) Pub Date : 2024-04-15 Kaori Tateyama, Shingo Umemoto, Shohei Iwano, Takashi Hirano, Masashi Suzuki
This study aimed to examine the characteristics of nasal and imaging findings of sinonasal lesions in granulomatosis with polyangiitis (GPA) patients and how these lesions change over time in both the active and remission phases of the disease. We retrospectively reviewed GPA patients with sinonasal lesions who were followed up at our department between January 2005 and December 2020. The following
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Post-treatment magnetic resonance imaging predicts outcomes of maxillary sinus cancer treatment using super-selective intra-arterial infusion of high-dose cisplatin with concomitant radiotherapy (RADPLAT) Auris Nasus Larynx (IF 1.7) Pub Date : 2024-04-15 Hideomi Yamauchi, Akira Baba, Nobuhiro Ogino, Satoshi Matsushima, Hirokazu Ashida, Masato Nagaoka, Hiroya Ojiri
This study aimed to evaluate the prognostic value of magnetic resonance imaging (MRI) findings in predicting local recurrence in patients with maxillary sinus cancer treated with super-selective intra-arterial infusion of high-dose cisplatin with concomitant radiotherapy (RADPLAT). This single-center retrospective study included consecutive patients with maxillary sinus squamous cell carcinoma, who
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Post-earthquake dizziness and its psychiatric comorbidities among adolescents following the 2023 Kahramanmaraş earthquakes in Turkey Auris Nasus Larynx (IF 1.7) Pub Date : 2024-04-15 Seda Bozduman Çelebi, Berhan Akdağ
Natural disasters, such as earthquakes, have detrimental effects on mental health. The occurrence of dizziness following earthquakes, termed post-earthquake dizziness syndrome (PEDS), has been noted in the epicenter and surrounding areas. The current study aimed to explore the prevalence of PEDS and its association with psychiatric disorders among adolescents. The sample consisted of 100 adolescents
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Impact of COVID-19 pandemic on the number of otolaryngologic surgeries in Japan Auris Nasus Larynx (IF 1.7) Pub Date : 2024-04-01 Megumi Koizumi, Hiroyuki Ohbe, Sayaka Suzuki, Yohei Hashimoto, Hiroki Matsui, Kiyohide Fushimi, Tatsuya Yamasoba, Hideo Yasunaga
Previous studies show that the COVID-19 pandemic affected the number of surgeries performed. However, data on the association between the COVID-19 pandemic and otolaryngologic surgeries according to subspecialties are lacking. This study was performed to evaluate the impact of the COVID-19 pandemic on various types of otolaryngologic surgeries. Methods. We retrospectively identified patients who underwent
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Safety of cricotracheostomy with skin and tracheal membrane flaps for severe COVID-19 patients Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-29 Kosuke Tochigi, Hikaru Sakamoto, Kazuhiro Omura, Hisashi Kessoku, Teppei Takeda, Ryoji Oguro, Hiromi Kojima, Yasuhiro Tanaka
Airway surgery is performed for COVID-19 patients who require long-term tracheal intubation and mechanical ventilation. Tracheostomy sometimes causes postoperative complications represented by bleeding at a relatively high rate in COVID-19 patients. As an alternative surgical procedure to tracheostomy, cricotracheostomy may reduce these complications, but few studies have examined its safety. Data
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Recent advances in Otology: Current landscape and future direction Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-29 Makoto Hosoya, Sho Kurihara, Hajime Koyama, Noritaka Komune
Hearing is an essential sensation, and its deterioration leads to a significant decrease in the quality of life. Thus, great efforts have been made by otologists to preserve and recover hearing.
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Prognostic value of electroneurography using the midline method for predicting the development of synkinesis after peripheral facial palsy Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-29 Aishi Okazaki, Haruki Nakano, Shin-Ichi Haginomori, Yusuke Ayani, Yuko Inaka, Akiko Ozaki, Yusuke Kikuoka, Takaki Inui, Ayumi Nakazawa, Shin-Ichi Wada, Ryo Kawata
The prognostic value of electroneurography (ENoG) for predicting the incidence of synkinesis is reportedly about 40 % using the formal standard method (ENoG-SM). However, the prognostic value of ENoG using the newly developed midline method (ENoG-MM) has not been determined. The aim of this study was to demonstrate the optimal prognostic value and advantages of ENoG-MM for predicting the incidence
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Persistent postural-perceptual dizziness: A functional neuro-otologic disorder Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-29 Chihiro Yagi, Akira Kimura, Arata Horii
Persistent postural-perceptual dizziness (PPPD) is a functional neuro-otologic disorder that is the most frequent cause of chronic vestibular syndrome. The core vestibular symptoms include dizziness, unsteadiness, and non-spinning vertigo, which are exacerbated by an upright posture or walking, active or passive motion, and exposure to moving or complex visual stimuli. PPPD is mostly precipitated by
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Complications including dysphagia following transoral non-robotic surgery for pharyngeal and laryngeal squamous cell carcinoma: A retrospective multicenter study Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-27 Koji Ushiro, Yoshiki Watanabe, Yo Kishimoto, Yoshitaka Kawai, Shintaro Fujimura, Ryo Asato, Takashi Tsujimura, Ryusuke Hori, Yohei Kumabe, Kaori Yasuda, Hisanobu Tamaki, Takehiro Iki, Yoshiharu Kitani, Keisuke Kurata, Tsuyoshi Kojima, Kuniaki Takata, Shinpei Kada, Shinji Takebayashi, Shogo Shinohara, Kiyomi Hamaguchi, Masakazu Miyazaki, Tadashi Ikenaga, Toshiki Maetani, Hiroyuki Harada, Tomoyuki Haji
Transoral surgery is a minimally invasive treatment but may cause severe dysphagia at a lower rate than chemoradiotherapy. We compared clinical information, surgical complications, and swallowing function in patients who underwent transoral nonrobotic surgery for laryngo-pharyngeal squamous cell carcinoma between 2015 and 2021 in a multicenter retrospective study. Six hundred and forty patients were
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Prediction of the efficacy of proton-pump inhibitors in patients with contact granuloma using 24-hour combined dual channel pH/impedance monitoring Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-27 Bo Hae Kim, Hanaro Park, Cheol Min Shin, Gene Huh, Young Ho Jung, Woo-Jin Jeong
We aimed to evaluate the treatment outcomes of proton-pump inhibitors (PPIs) in patients with contact granuloma (CG) and to investigate the parameters of 24 h combined dual channel pH/impedance (24 h pH/MII) monitoring, which are reliable for predicting the response to PPI of CG patients. We reviewed the medical records of patients with CG who had been treated with PPIs and had completed more than
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Practical guide for the diagnosis and management of primary ciliary dyskinesia Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-27 Kazuhiko Takeuchi, Miki Abo, Hiroshi Date, Shimpei Gotoh, Atsushi Kamijo, Takeshi Kaneko, Naoto Keicho, Satoru Kodama, Goro Koinuma, Mitsuko Kondo, Sawako Masuda, Eri Mori, Kozo Morimoto, Mizuho Nagao, Atsuko Nakano, Kaname Nakatani, Naoya Nishida, Tomoki Nishikido, Hirotatsu Ohara, Yosuke Okinaka, Hiroshi Sakaida, Koji Shiraishi, Isao Suzaki, Ichiro Tojima, Yasuhiro Tsunemi, Keigo Kainuma, Nobuo Ota
Primary ciliary dyskinesia (PCD) is a relatively rare genetic disorder that affects approximately 1 in 20,000 people. Approximately 50 genes are currently known to cause PCD. In light of differences in causative genes and the medical system in Japan compared with other countries, a practical guide was needed for the diagnosis and management of Japanese PCD patients. An ad hoc academic committee was
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Pre- and post-operative semicircular canal function evaluated by video head impulse test in patients with vestibular schwannoma Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-26 Keishi Fujiwara, Shinya Morita, Hiroaki Motegi, Shigeru Yamaguchi, Yukitomo Ishi, Kimiko Hoshino, Atsushi Fukuda, Makoto Kobayashi, Yuji Nakamaru, Miki Fujimura, Akihiro Homma
To evaluate pre- and post-operative semicircular canal function in patients with vestibular schwannoma (VS) by the video Head Impulse Test (vHIT). Nineteen patients with VS who underwent surgery were enrolled in this study. The gain in vestibulo-ocular reflex (VOR) and the degree of scatter in catch-up saccades were examined pre- and post-operatively for the semicircular canals in VS patients. Ten
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The error patterns of phonemes in children with prelingual hearing loss: A comparison between hearing aid and cochlear implant users Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-26 Yuri Nishiyama, Shujiro Minami, Ryoko Ijuin, Tomoko Kuroki, Ayako Tendo, Yuko Kusui, Satoko Wakabayashi, Kimitaka Kaga
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Usefulness of endoscopic endonasal underwater surgery using a combination of coblation and a lens-cleaning system for hemostasis in hereditary hemorrhagic telangiectasia Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-23 Hiroshi Sakaida, Masayoshi Kobayashi, Kazuhiko Takeuchi
Hemostatic procedures for controlling nasal bleeding in refractory diseases such as hereditary hemorrhagic telangiectasia (HHT) can be challenging. In this report, we present a novel technique for underwater endoscopic endonasal hemostatic surgery, which was performed on a 69-year-old man with HHT. The patient had been experiencing frequent episodes of nasal bleeding and had many telangiectasias in
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Effects of the Kahramanmaras, Turkey 2023 earthquakes on balance perception, dizziness and post-traumatic stress: A relational screening model between subjective balance problems and post-traumatic stress Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-23 Deniz Uğur Cengiz, Feyza İnceoğlu, Ercan Karababa, Anı Parabakan Polat, Tuğba Yılmaz, Berna Deniz Kuntman, Asya Fatma Men, Evren Hızal
The aim of the present study was to investigate the effects of the February 6, 2023, earthquakes in Turkey and recurrent aftershocks on balance and post-traumatic stress in surviving victims. Our study included 1004 participants aged 18–65 years who were exposed to the February 6 earthquakes and aftershocks in Turkey. After obtaining online consent from all participants, the Vertigo Symptom Scale (VSS)
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Current management of carotid body tumors Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-23 Hiroyuki Ozawa
Carotid body tumors (CBTs) are neoplasms that occur at the bifurcation of the carotid artery and are pathologically classified as paragangliomas. In the 4th edition of the WHO classification, paragangliomas are categorized as neoplasms with malignant potential. Clinically, about 5% of CBTs present with malignant features such as metastasis. Currently, it is challenging to distinguish between tumors
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Histological changes in the olfactory bulb and rostral migratory stream due to interruption of olfactory input Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-23 Yukari Nakamura, Takaki Miwa, Hideaki Shiga, Hiromi Sakata, Daichi Shigeta, Toshihisa Hatta
Periglomerular and granule cells in the adult mammalian olfactory bulb modulate olfactory signal transmission. These cells originate from the subventricular zone, migrate to the olfactory bulb via the Rostral Migratory Stream (RMS), and differentiate into mature cells within the olfactory bulb throughout postnatal life. While the regulation of neuroblast development is known to be affected by external
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Otologic disease trends in Japan post-COVID-19 outbreak: A retrospective time-series analysis Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-23 Keisuke Kondo, Keiji Honda, Keiichi Goshima, Norihiko Inoue, Daisuke Shinjo, Takeshi Tsutsumi, Kiyohide Fushimi
To evaluate the potential impact of coronavirus disease 2019 (COVID-19) and vaccinations on otologic diseases, including facial nerve paralysis (including Ramsay Hunt syndrome), vestibular neuritis, sudden sensorineural hearing loss, and Meniere's disease. In this retrospective study, we conducted a time-series analysis employing a causal impact algorithm on a large-scale inpatient database in Japan
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Potential application of electronic odor diffuser in olfaction testing Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-23 Tadashi Ishimaru, Hitomi Ishimaru
Different olfactory tests have been performed by otorhinolaryngologists in different parts of the world. For example, the University of Pennsylvania Smell Identification Test (UPSIT) has been used in the U.S., whereas the Sniffin’ Sticks Test has been used in Europe, and similarly, T&T olfactometry is used in Japan. Although audiometers with electronic oscillators have long been used in hearing tests
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The effect of increased listening effort on the balance performance of patients with compensated vestibular lesion Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-23 Nashwa Nada, Mai Mohammed El-Gohary, Wessam Mostafa Essawy
This study investigated the effects of listening effort (LE) on balance in patients with compensated vestibular deficits compared to healthy peers. The subjects included two main groups: a control group of 15 healthy subjects and a study group of 19 patients with compensated vestibular pathology. The computerized dynamic posturography test (CDP) was conducted without the speech-in-noise task as a baseline
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Novel evaluation method for facial nerve palsy using 3D facial recognition system in iPhone Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-22 Koki Hasebe, Tsuyoshi Kojima, Yusuke Okanoue, Ryohei Yuki, Hirotaka Yamamoto, Shuya Otsuki, Shintaro Fujimura, Ryusuke Hori
While subjective methods like the Yanagihara system and the House-Brackmann system are standard in evaluating facial paralysis, they are limited by intra- and inter-observer variability. Meanwhile, quantitative objective methods such as electroneurography and electromyography are time-consuming. Our aim was to introduce a swift, objective, and quantitative method for evaluating facial movements. We
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Evaluation of quality of life for patients with resolved facial nerve palsy Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-22 Keishi Fujiwara, Shinya Morita, Atsushi Fukuda, Kimiko Hoshino, Makoto Kobayashi, Yuji Nakamaru, Yasushi Furuta, Akihiro Homma
The quality of life (QOL) for patients with resolved facial nerve palsy has not been evaluated adequately. The objective of this study is to investigate QOL for patients with resolved facial nerve palsy. Forty-seven patients with resolved facial nerve palsy were included and the patients’ QOL was evaluated using the Facial Clinimetric Evaluation Scale (FaCE Scale). Twenty-two of the 47 patients (46
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Antiviral treatment for Ramsay Hunt syndrome: A systematic review and meta-analysis Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-22 Takashi Fujiwara, Kensuke Uraguchi
This study aimed to reveal the efficacy and safety of antivirals in patients with Ramsay Hunt syndrome. A literature search was conducted in PubMed, Ichushi-Web, and Cochrane Central Register of Controlled Trials. Published randomized controlled trials and observational studies, which compared antivirals versus placebo/no treatment for Ramsay Hunt syndrome, were included in the meta-analysis. The primary
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Simultaneous disturbance of NHE1 and LOXL2 decreases tumorigenicity of head and neck squamous cell carcinoma Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-22 Yuji Hayashi, Shoko Miyoshi, Itaru Watanabe, Nagomi Yano, Kodai Nagashio, Mihiro Kaneko, Teppei Kaminota, Tomoyoshi Sanada, Yuki Hosokawa, Takashi Kitani, Sohei Mitani, Mohammed E Choudhury, Hajime Yano, Junya Tanaka, Naohito Hato
Although there have been brilliant advancements in the practical application of therapies targeting immune checkpoints, achieving success in targeting the microenvironment remains elusive. In this study, we aimed to address this gap by focusing on Na / H exchanger 1 (NHE1) and Lysyl Oxidase Like 2 (LOXL2), which are upregulated in head and neck squamous cell carcinoma (HNSCC) cells. The malignancy
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Update on pediatric tracheostomy Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-22 Manabu Komori
Pediatric tracheostomy has been widely performed since the 1800s, and in recent years, with advances in neonatal medicine, it has been performed at younger ages, starting at 0. In addition, advances in surgical techniques and postoperative tube management have reduced complications.
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Risk of COVID-19 in pediatric population and the effects of COVID-19 vaccination: A retrospective cohort study Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-22 Kassandra Corona, Janisah Amirah I. Saripada, Kendall Wermine, Sydney Seavey, Bibiana Toro Figueira, Joshua J. LaHaye, Yuki Yoshiyasu, Shiva Daram, Brian McKinnon
Prior studies have demonstrated the adverse effects of upper respiratory infections on the pediatric population, such as increased risk for acute otitis media (AOM). Other studies have noted decreased otitis media complaints during the COVID-19 pandemic. This project aims to identify whether individuals who tested positive for COVID-19 at the Emergency Department (ED) visit had an increased risk of
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Surgical management of secondary acquired cholesteatoma depends on its characteristics Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-22 Yoshihiko Esu, Satoru Tamii, Hiromi Kanazawa, Yukiko Iino, Naohiro Yoshida
Cholesteatoma secondary to tympanic perforation, known as “secondary acquired cholesteatoma” may progress slower than a retraction pocket cholesteatoma, with less bone destruction and fewer intracranial complications. However, complete surgical removal remains difficult because the pathological epithelium on the marginal side of the extension is not covered by the subepithelial layer of the cholesteatoma
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Relationship between olfactory and gustatory functions: The Iwaki health promotion project 2019 Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-22 Kazutaka Yamauchi, Daisuke Matsushita, Nami Shimizume, Reiko Kudo, Yusuke Kohama, Akiko Miyazaki, Hiromu Taguchi, Takashi Hirao, Fuminori Kawabata, Yuko Kawabata, Keisuke Sanematsu, Shingo Takai, Junichi Yamazoe, Kenichi Anabuki, Ken Aoshima, Yoshiko Takahashi, Shinichi Goto, Akira Sasaki, Noriatsu Shigemura, Atsushi Matsubara
Olfactory and gustatory functions are important sensory aspects in humans. Although they are believed to influence each other, their interrelationship is not well understood. In this study, we aimed to investigate the relationship between the olfactory and gustatory functions based on the results of a large-scale epidemiological study (Iwaki Health Promotion Project) of the general local population
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Acquired tracheobronchomalacia developed following voice prosthesis implantation Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-22 Hirofumi Omori, Takahiro Wakasaki, Takahiro Hongo, Fumihide Rikimaru, Satoshi Toh, Yuichiro Higaki, Muneyuki Masuda
Acquired tracheobronchomalacia (ATBM) is a condition in which the tracheobronchial wall and cartilage progressively lose their rigidity, resulting in dynamic collapse during exhalation. In this report, we present a case of ATBM that developed following voice prosthesis implantation. To the best of our knowledge, this is the first documented case of such a condition in the medical English literature
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Effectiveness of antibiotic therapy for early recurrence of peritonsillar cellulitis and abscesses: A retrospective cohort study Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-22 Keisuke Kondo, Norihiko Inoue, Keiji Honda, Kiyohide Fushimi
Short-term recurrence is common in patients with peritonsillar cellulitis and abscesses, leading to socioeconomic problems. Early switching from intravenous to oral antibiotics is feasible for treating certain diseases. However, reports on early switching and total antibiotic administration duration in peritonsillar cellulitis and abscesses are limited. This study aimed to determine the appropriate
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Effects of submucoperichondrial application of platelet-rich plasma on nasal mucosal healing after septoplasty Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-22 Senem Kurt Dizdar, Uğur Doğan, Mehmet Ece, Kerem Sami Kaya, Nurullah Seyhun, Suat Turgut
Our aim is to investigate the effects of the submucoperichondrial application of Platelet Rich Plasma (PRP) on nasal mucosal healing after septoplasty surgery. This prospective randomized observational study was conducted between July 2019 and February 2021, with 40 patients aged 18–60 years who underwent closed the only septoplasty operation for similar septal deviations. Patient divided into two
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Functional vagal paraganglioma developing 15 years after resection of a retroperitoneal paraganglioma Auris Nasus Larynx (IF 1.7) Pub Date : 2024-03-22 Fumiya Kojima, Kazuchika Ohno, Naoki Fushimi, Ryosuke Takahashi, Akihisa Tasaki, Takahiro Asakage
The patient, a 40-year-old woman, was diagnosed as having a functional right vagal paraganglioma (PGL) 15 years after undergoing resection for a retroperitoneal PGL. I-MIBG scintigraphy showed no accumulation, but as the blood noradrenaline and urinary normetanephrine concentrations were elevated, the tumor was judged as being functional, and surgery was scheduled. The patient was started on doxazosin
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Withdrawal notice to: “Listening handicap in tinnitus patients by controlling extended high frequencies - Effort or fatigue?” [Auris Nasus Larynx 51 (2024) 198-205] Auris Nasus Larynx (IF 1.7) Pub Date : 2024-02-26 Eser Sendesen, Didem Turkyilmaz
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Corrigendum to “Long-term changes in serum squamous cell carcinoma antigen levels after surgery in patients with sinonasal inverted papilloma” [Auris Nasus Larynx volume 49 (2022) 697–702] Auris Nasus Larynx (IF 1.7) Pub Date : 2024-01-03 Yoshiaki Kitamura, Seiichiro Kamimura, Tatsuya Fujii, Ryo Kanamura, Junya Fukuda, Eiji Kondo, Takahiro Azuma, Go Sato, Noriaki Takeda
Abstract not available
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From research to clinical practice: An analysis of 226 Hz-probe tone tympanometry to identify otitis media with effusion in children Auris Nasus Larynx (IF 1.7) Pub Date : 2023-12-21 Kátia de Freitas Alvarenga, Alana Ribeiro de Melo, Marina Saes Rays, Alice Andrade Lopes Amorim, Lilian Cássia Bórnia Jacob, Eliene Silva Araújo
(1) To calculate the sensitivity and specificity of tympanometry with a 226 Hz probe to identify middle ear condition in children; (2) To propose the intersection range of static compliance and tympanometric peak pressure values obtained in ears with and without middle ear effusion. 224 children's ears without middle ear alteration, with a mean age of 1 year and 4 months (GI), and 56 children's ears
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Vestibular compensation: Neural mechanisms and clinical implications for the treatment of vertigo Auris Nasus Larynx (IF 1.7) Pub Date : 2023-12-19 Noriaki Takeda, Kazunori Matsuda, Junya Fukuda, Go Sato, Atsuhiko Uno, Tadashi Kitahara
After unilateral peripheral vestibular lesions, the neural activity of neurons in the ipsi-lesional medial vestibular nucleus (ipsi-MVe) are markedly decreased, resulting in static and dynamic asymmetries of the vestibulo-ocular and vestibulo-spinal reflexes. Consequently, static vestibular symptoms such as spontaneous nystagmus and postural deviation and dynamic vestibular symptoms such as oscillopsia
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Long term effects of cochlear implant surgery on vestibular system in pediatric population Auris Nasus Larynx (IF 1.7) Pub Date : 2023-12-08 Ata Alperen Erşahan, Hasan Mervan Değer, Merve Durgut, Murat Öztürk, Fatih Mutlu
The aim was to evaluate the vestibular system of children who had undergone cochlear implant surgery and to compare them with the healthy population by vestibulo-ocular reflex (VOR) gains in unilateral and bilateral implant users, with the implants both on and off. Patients older than 5 years who had undergone cochlear implant surgery between 2012 and 2020 and who were cochlear implant users for at
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Efficacy, safety, and tissue penetration of solithromycin in Japanese patients with otorhinolaryngological infections Auris Nasus Larynx (IF 1.7) Pub Date : 2023-12-07 Yuichi Kurono, Fumiyo Kudo, Akira Watanabe, Takahiro Yamatake, Satoshi Shimada, Kenji Suzuki
To assess the efficacy, safety, and tissue penetration of solithromycin for the treatment of otorhinolaryngological infections, we conducted three studies: a tissue penetration study with patients scheduled to undergo otorhinolaryngological tissue removal, an open-label study comprising patients with otitis media, pharyngitis, laryngitis, and tonsillitis, and a non-inferiority study compared with high-dose
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Sinonasal microbiome and inflammatory profiles in fungal ball and chronic rhinosinusitis Auris Nasus Larynx (IF 1.7) Pub Date : 2023-12-06 Daeyoung Roh, Ji-Hyeon Shin, Soo Whan Kim, Sung Won Kim, Byung-Guk Kim, Jin-Hee Cho, Yong-Jin Park, Do Hyun Kim
Fungal balls (FB) are the main form of non-invasive fungal rhinosinusitis found in immunocompetent hosts. Bacterial coinfection affects clinical symptoms. We investigated the sinonasal microbiome and inflammatory profiles in FB and chronic rhinosinusitis (CRS) patients. Thirty-three participants were prospectively recruited. Nasal swab samples and sinonasal tissues were collected from controls, and
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Peritonsillar abscess caused by Mycoplasma hominis and Fusobacterium necrophorum following oral sex Auris Nasus Larynx (IF 1.7) Pub Date : 2023-12-02 Hiroshi Morioka, Hideyuki Kaida, Mitsuru Nishio, Kenji Suga
is a bacterium that colonizes the genital tract of some females and males, as well as their respiratory tracts. Although only two cases of deep neck infection have been reported, the associations between the onset and sexual intercourse have not been reported. A healthy 19-year-old female was diagnosed with a left peritonsillar abscess. The patient had sexual intercourse with a new partner, including
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Understanding hereditary hemorrhagic telangiectasia: From genetic anomalies to systemic manifestations, quality of life, and epistaxis management—Exploring the otolaryngologist's integral role Auris Nasus Larynx (IF 1.7) Pub Date : 2023-11-25 Masaki Hayama, Yohei Maeda, Sho Obata, Takeshi Tsuda, Kazuya Takeda, Takeo Nishida, Hidenori Inohara
Hereditary hemorrhagic telangiectasia (HHT), also known as Osler–Rendu–Weber syndrome, is a rare autosomal dominant disorder characterized by vascular malformations. This comprehensive review aimed to provide an overview and summarize various aspects of HHT, including the genetic abnormalities, complications associated with visceral arteriovenous malformations (AVMs), prognosis of HHT, quality of life
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Lipids and sudden sensorineural hearing loss: A bidirectional two-sample Mendelian randomization analysis Auris Nasus Larynx (IF 1.7) Pub Date : 2023-11-22 Kunlin Pu, Li Li, Yan Qiu, Hongmei Song
While numerous observational studies have indicated an association between lipids and Sudden Sensorineural Hearing Loss (SSNHL), it remains uncertain whether dyslipidemia serves as a causal risk factor for SSNHL. Our objective is to elucidate the potential causal relationship between lipid levels and SSNHL through Mendelian randomization analysis. The primary and secondary lipid data used in this study
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Effectiveness of FEES with artificial intelligence-assisted computer-aided diagnosis Auris Nasus Larynx (IF 1.7) Pub Date : 2023-11-18 Mitsuyoshi Imaizumi, Weihao Weng, Xin Zhu, Shigeyuki Murono
FEES is a standard procedure for diagnosing dysphagia. However, appropriate evaluation of FEES findings is difficult for inexperienced evaluators. Recent progress in deep learning has highlighted the use of artificial intelligence-assisted computer-aided diagnosis (AI-assisted CAD) in medical applications. We investigated the detection accuracy of FEES findings evaluated by inexperienced evaluators
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Useful combination of Gehanno method, polyglycolic acid sheet and fibrin glue for prevention of postoperative dysfunction after soft palate resection with TORS Auris Nasus Larynx (IF 1.7) Pub Date : 2023-11-18 Kiyoaki Tsukahara, Kenji Hanyu, Akira Shimizu
Oropharyngeal cancer requiring combined resection of the soft palate is relatively out of indication for transoral robotic surgery (TORS) due to postoperative functional problems. We report the case of a patient with oropharyngeal cancer in which half of the soft palate was resected, and good function was maintained using the Gehanno method, polyglycolic acid (PGA) sheet and fibrin glue. The patient
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New insights into chronic rhinosinusitis associated with IgG4-related disease Auris Nasus Larynx (IF 1.7) Pub Date : 2023-11-14 Kenichi Takano, Ryuta Kamekura, Tsuyoshi Okuni, Keisuke Yamamoto
IgG4-related disease (IgG4-RD) is a chronic inflammatory disorder characterized by elevated IgG4 serum levels, abundant IgG4-positive plasmacyte infiltration, and fibrosis of various organs, including the head and neck. We aimed to provide an overall review of IgG4-RD in the sinonasal region and propose a novel entity and criteria of chronic rhinosinusitis (CRS) associated with IgG4-RD as “IgG4-CRS
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Targeted next-generation sequencing of Japanese patients with sinonasal mucosal melanomas identifies frequent NRAS and CTNNB1 mutations Auris Nasus Larynx (IF 1.7) Pub Date : 2023-11-10 Nayuta Tsushima, Satoshi Kano, Kanako C. Hatanaka, Takayoshi Suzuki, Seijiro Hamada, Hiroshi Idogawa, Yuji Nakamaru, Masanobu Suzuki, Yutaka Hatanaka, Akihiro Homma
Mucosal melanoma is a rare malignancy; however, the reported incidence rate of mucosal melanoma is higher in Asians than in Caucasians. Sinonasal mucosal melanoma (SNMM) is an aggressive malignancy with a poor prognosis due to distant metastasis. Systemic therapy with BRAF inhibitor and MEK inhibitor is one of the standards of care for cutaneous melanoma patients with BRAF V600 mutations. However,
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Central node dissection from the perspective of lateral neck node metastasis in papillary thyroid carcinoma Auris Nasus Larynx (IF 1.7) Pub Date : 2023-11-07 Masataka Taniuchi, Ryo Kawata, Tetsuya Terada, Masaaki Higashino, Teruhito Aihara, Tsuyoshi Jinnin
Controversy exists on how to handle central lymph nodes in papillary thyroid carcinoma, particularly regarding indications for prophylactic central neck dissection (CND). Central node metastases are more difficult to diagnose preoperatively than lateral node metastases. We enrolled 493 patients with papillary thyroid carcinoma treated at our department in the past 22 years. Metastatic lymph nodes were
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Safety and efficacy of high tracheostomy with inferior retraction of the thyroid isthmus Auris Nasus Larynx (IF 1.7) Pub Date : 2023-11-04 Daisuke Iokura, Yusuke Okanoue, Shuya Otsuki, Kengo Oe, Kuniaki Takata, Akihito Tarui, Tsuyoshi Kojima
In typical surgical tracheostomy, the thyroid isthmus is divided or retracted superiorly and preserved. However, at our institution, the thyroid isthmus is retracted inferiorly and preserved. Thereafter, a tracheal incision is made above the thyroid isthmus. This method, hereinafter defined as high tracheostomy, has the advantage of facilitating immediate access to the trachea in a superficial position;
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Risk factors for occurrence and progression of external auditory canal cholesteatoma Auris Nasus Larynx (IF 1.7) Pub Date : 2023-11-02 Saori Seki, Tomonori Sugiyama, Saori Kikuchi, Yukiko Iino
External auditory canal cholesteatoma (EACC) is characterized by retained squamous debris within the external canal and variable amounts of localized bone destruction. The etiology of primary EACC remains incompletely understood. This study was conducted to analyze the clinical features and backgrounds of patients with primary EACC and to clarify the risk factors for the occurrence and progression
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Effects on hearing after long-term use of iron chelators in beta-thalassemia: Over twenty years of longitudinal follow-up Auris Nasus Larynx (IF 1.7) Pub Date : 2023-10-29 Mirko Aldè, Umberto Ambrosetti, Marianna Giuditta, Elena Cassinerio, Gioia Piatti
The role of iron chelation in causing hearing loss (HL) is still unclear. The present study assessed the prevalence of HL among transfusion-dependent thalassemia (TDT) patients who underwent audiological follow-up over a 20-year period. We retrospectively analyzed clinical records and audiological tests from January 1990 (T0) to December 2022 (T22) of a group of TDT patients who received iron chelation
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Outcomes of regenerative treatment for over 200 patients with tympanic membrane perforation Auris Nasus Larynx (IF 1.7) Pub Date : 2023-10-25 Rie Kanai, Shin-ichi Kanemaru, Tomoya Yamaguchi, Shin-ichiro Kita, Toru Miwa, Akiko Kumazawa, Jun Okamoto, Misaki Yoshida, Hiroyuki Harada, Toshiki Maetani
To evaluate outcomes of a regenerative treatment (RT) for over 200 patients with tympanic membrane perforation (TMP). The RT-TMP method involves a gelatin sponge, basic fibroblast growth factor (bFGF) and fibrin glue. The study population included 216 patients and 234 ears (male: female =100:116; age 1–93 years). All enrolled patients were treated with RT-TMP in which TMP edges were disrupted mechanically
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The construction and validation of prognostic prediction model for sudden sensorineural hearing loss in middle-aged and elderly people Auris Nasus Larynx (IF 1.7) Pub Date : 2023-10-21 Zhiqiang Zhang, Changxu Yu, Xueyan Wang, Sitong Ge, Guanhong Zhai, Shurui Si, Tianyi Ma, Fuyao Li, Zhezhu Cui, Xianghua Jin, Yulian Jin
Idiopathic sudden sensorineural hearing loss (ISSNHL), as an otologic emergency, is commonly encountered and its prevalence has been climbing every year recently. To our knowledge, the prognosis of middle-aged and elderly patients is worse than that of young patients. Previous researches mainly focused on the adult population, which was considered as prognostic models who performed hearing recovery
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Estimated incidence and characteristics of vestibular neuritis in Japan: A nationwide survey Auris Nasus Larynx (IF 1.7) Pub Date : 2023-10-13 Shinichi Iwasaki, Takuya Kawahara, Takenori Miyashita, Susumu Shindo, Masahito Tsubota, Aki Inoue, Kishiko Sunami, Hideo Shojaku, Committee for Epidemiology of the Japan Society for Equilibrium Research
To assess the annual incidence of vestibular neuritis (VN) in the Japanese population. We conducted a mail-based survey targeting otolaryngologic clinics and hospitals across Japan to estimate the annual number of patients who were newly-diagnosed with VN during the one-year period of 2021. Using a stratified sampling method, we selected 1,107 departments and asked them to report the number of new
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Clinical characteristics in Japanese patients with chronic rhinosinusitis who underwent endoscopic sinus surgery Auris Nasus Larynx (IF 1.7) Pub Date : 2023-10-13 Natsuki Inoue, Tomomitsu Hirota, Akihiro Hatano, Mika Nakano, Daiki Nakashima, Tsuguhisa Nakayama, Mayumi Tamari, Mamoru Yoshikawa
There is heterogeneity in the pathophysiology of chronic rhinosinusitis (CRS). Obtaining a detailed understanding of patient profiles in specific regions can provide valuable information not only for clinical practice but also future research plans. The aim of this study was to investigate the characteristics of patients who underwent endoscopic sinus surgery (ESS) for CRS. This retrospective, single-center
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Botulinum toxin injection for abductor spasmodic dysphonia under cervical ultrasonography guidance Auris Nasus Larynx (IF 1.7) Pub Date : 2023-10-12 Chikako Kunieda, Fumiaki Nin, Toshimitsu Ohashi, Kiyohito Hosokawa, Yusuke Watanabe, Takenori Ogawa, Tomohiro Mori, Takeharu Kanazawa
Ultrasound (US) imaging effectively provides real-time anatomical information for clinical examinations. In otolaryngology, US imaging can visualize laryngeal muscles as well as cervical muscles. Here we present the case where US imaging was used while injecting botulinum toxin (BT) for the treatment of abductor spasmodic dysphonia, which provided definite results. We could visualize not only the injection
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Artificial intelligence-based diagnosis of the depth of laryngopharyngeal cancer Auris Nasus Larynx (IF 1.7) Pub Date : 2023-10-12 Kohei Yumii, Tsutomu Ueda, Daisuke Kawahara, Nobuyuki Chikuie, Takayuki Taruya, Takao Hamamoto, Sachio Takeno
Transoral surgery (TOS) is a widely used treatment for laryngopharyngeal cancer. There are some difficult cases of setting the extent of resection in TOS, particularly in setting the vertical margins. However, positive vertical margins require additional treatment. Further, excessive resection should be avoided as it increases the risk of bleeding as a postoperative complication and may lead to decreased
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Improvements in blood IGF-1 and skeletal age following adenotonsillectomy for growth delay in children with obstructive sleep apnea Auris Nasus Larynx (IF 1.7) Pub Date : 2023-10-08 Yuma Yoshioka, Shoji Matsune, Kuwon Sekine, Mariko Ishida, Nozomu Wakayama, Satoshi Yamaguchi, Kimihiro Okubo
In children with obstructive sleep apnea (OSA) who underwent adenotonsillectomy (AT), we measured body height and weight using standard deviation (SD) scores, insulin-like growth factor 1 (IGF-1), and skeletal age using carpal radiography. We then compared these values before and after surgery with the aim of investigating postoperative improvements in growth hormone (GH) deficiency. Subjects comprised
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Characteristics of pure tone audiogram in patients with untreated sporadic vestibular schwannoma: Analysis of audiometric shape and interaural differences stratified by age and mode of onset Auris Nasus Larynx (IF 1.7) Pub Date : 2023-10-01 Nobuyoshi Tsuzuki, Tsubasa Kitama, Koichiro Wasano, Takeshi Wakabayashi, Makoto Hosoya, Takanori Nishiyama, Hiroyuki Ozawa, Naoki Oishi