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“Cell blocking” the parasitic imposter: In a rare case of isolated pulmonary cysticercosis Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-04-12 Kush Kumar Singh, Abhilasha Kochhar, Chakshu Bansal, Latika Gupta, Samir Malhotra
Isolated pulmonary cysticercosis is a rare manifestation of human cysticercosis which mainly affects central nervous system, skeletal muscles, eyes and subcutaneous tissues. Pulmonary involvement is usually a part of disseminated disease and mainly presents as bilateral pulmonary nodules. We report a rare case of isolated pulmonary cysticercosis presenting as lung cyst with pleural effusion. The diagnosis
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Diagnostic values of SurePath liquid‐based cytology versus conventional smear in thyroid aspiration samples: A 13‐year experience at a single institution Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-04-10 Wen‐Ying Lee, Hsiu‐Chu Wang, Lee‐E Huang, Min‐Hui Tseng, Shu‐Hui Chiang, Ching‐Chien Lee
BackgroundFine needle aspiration cytology (FNAC) is the most useful tool in the diagnosis of thyroid nodules. Liquid‐based cytology (LBC) is replacing the conventional smear (CS) for evaluation of thyroid FNAC. In our institution, thyroid FNAC preparation was changed from CS to LBC SurePath in July 2016. This study aimed to compare the diagnostic value of SurePath with that of CS in thyroid lesions
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Intraparotid plexiform neurofibroma: A rare diagnostic challenge Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-04-10 Adil Aziz Khan, Sana Ahuja, Sufian Zaheer
Isolated intraparotid neurofibromas are exceptionally rare and often associated with neurofibromatosis type 1 (NF1). Diagnosing these tumors proves challenging because of the clinical resemblance to primary salivary gland masses. This case report details an 18‐year‐old with a painful, enlarging parotid mass, diagnosed through fine needle aspiration biopsy (FNAB) revealing myxoid stroma and spindle
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Cytomorphology of metastatic colonic MXD4::NUTM1‐rearranged sarcoma Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-04-10 Zachary Alan Wilkinson, Maria Luisa C. Policarpio‐Nicolas
This report describes the cytologic features of a recently described MXD4::NUTM1‐rearranged colonic sarcoma metastatic to the midclavicular soft tissue. Thirteen years ago, a 65‐year‐old woman presented with a cecal mass and subsequent liver mass. The cecal mass was diagnosed as malignant undifferentiated spindled and epithelioid neoplasm based on morphology and lack of tumor immunoreactivity with
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A case series of thyroid fine needle aspiration biopsies diagnosed as follicular neoplasm with oncocytic features Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-04-06 Constance V. Chen, Vimal Krishnan, Nancy Y. Greenland
Oncocytic lesions of the thyroid are a heterogeneous group encompassing nonneoplastic and neoplastic entities ranging from benign to malignant and have traditionally been classified as separate entities in thyroid pathology. To illustrate the diversity of these thyroid lesions, we describe three cases of fine needle aspiration biopsies (FNAB) diagnosed as Bethesda Category IV: Follicular neoplasm,
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Ewing sarcoma of the mandible: A rare case report and literature review Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-04-06 Özgecan Gündoğar, Neslihan Komut, Sibel Bektaş, Fatih Tetik, Neşe Uçar
Ewing sarcoma (ES) usually arises from long bones and affects the head and neck region in only 1%–4% of cases. We reported clinical, radiographic, cytomorphologic, and histomorphologic findings of the ES in the mandible, because of its rarity and radiologically misinterpreted as a parotid gland tumor. A 26‐year‐old male patient presented with a history of painfull cheek swelling. On magnetic resonance
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Fine needle aspiration biopsy in low‐ and middle‐income countries Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-04-05 Nikka Khorsandi, Ron Balassanian, Poonam Vohra
Fine needle aspiration biopsy (FNAB) in low‐ and middle‐income countries (LMIC), can provide minimally invasive, cost‐effective tissue diagnosis with rapid assessment and specimen triage, which is advantageous in these resource‐limited settings. Nevertheless, challenges such as equipment shortages, reagents, and lack of trained personnel exist. This article discusses the effectiveness of FNAB for diagnosis
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Non‐small cell lung carcinoma with ectopic gonadotropin production: A case report and review of the literature Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-04-05 Sara L. Mosaffa, Georgie Eapen, Neda Kalhor, Nour Sneige
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest.
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Duodenal gastrointestinal stromal tumor masquerading as an uncinate process pancreatic neoplasm Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-04-02 Brijdeep Singh, Reetu Kundu, Suvradeep Mitra, Harish Bhujade, Ashwani Sood, Jayanta Samanta, Vikas Gupta
CONFLICT OF INTEREST STATEMENT The authors declare no conflicts of interest.
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Performance of preferentially expressed antigen in melanoma (PRAME) immunohistochemistry for metastatic melanoma in cytology specimens Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-04-01 Mohammed Saad, Richard Cantley, Wei Hao, Zixi Wang, Dafydd Thomas, Liron Pantanowitz, Xiaobing Jin
BackgroundPreferentially expressed antigen in melanoma (PRAME) has been introduced as a new melanoma marker and potential target for immunotherapy. While PRAME immunohistochemistry (IHC) is well documented in surgical pathology, similar data in cytology are limited. Metastatic melanoma is frequently diagnosed via cytology samples in which IHC plays an important role. We aimed to accordingly evaluate
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ThyroSeq overview on indeterminate thyroid nodules: An institutional experience Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-30 Sam Sirotnikov, Christopher C. Griffith, Daniel Lubin, Chao Zhang, Nabil F. Saba, Dehong Li, Amanda Kornfield, Amy Chen, Qiuying Shi
BackgroundMolecular triage of indeterminate thyroid aspirates offers the opportunity to stratify the risk of malignancy (ROM) more accurately. Here we examine our experience with ThyroSeq v3 testing.MethodsWe analyzed 276 of 658 (42%) fine needle aspiration samples classified as indeterminate thyroid nodules using ThyroSeq v3 (Sept 2017–Dec 2019). The test provides a ROM and detects specific mutations
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Ditch the stains and the microscope: Clues in an unstained lymph node cytology smear observed with the ×1 objective Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-28 Elisabetta Maffei, Iginio Donatiello, Pio Zeppa, Alessandro Caputo
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest.
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Cytomorphological features of sebaceous carcinoma of the breast Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-27 Ken Misawa, Mikiko Kobayashi, Tomoko Yamamoto, Atsushi Sato
Sebaceous carcinoma of the breast is an extremely rare histological subtype of breast cancer, with fewer than 30 cases reported to date. Because of its extremely rare histological presentation, there are few case reports that highlight its cytological findings. In this case report, the cytomorphological features of a sebaceous carcinoma of the breast are described in detail. Cytomorphological analysis
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Letter to “Correlation of immediate prevalence of cervical squamous cell precancers and cancers with HPV genotype and age in women with LSIL cytology” Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-27 Liqing Chen, Shuang Niu, Feng Zhou
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Diagnostic utility of cytology in a patient with Epstein-Barr virus-positive mucocutaneous ulcer in palatine tonsils: A case report Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-27 Mieko Doi, Mei Hamada, Keisuke Ishizawa, Naoki Fushimi, Yasuhiro Kase, Tetsuo Ikezono, Jun-ichi Tamaru, Taketo Yamada
Epstein-Barr virus-positive mucocutaneous ulcer (EBVMCU) is a newly established immunodeficiency-related disease. Herein, we report a case of EBVMCU and focus on its cytological usefulness for diagnosis. An 82-year-old man manifested pharyngalgia, dysphagia, and oral pain. His medical history included rheumatoid arthritis that had been treated with methotrexate. Clinically, peritonsillar abscess was
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Letter to “Correlation of immediate prevalence of cervical squamous cell precancers and cancers with HPV genotype and age in women with LSIL cytology” Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-27 Onur Yavuz, İbrahim Karaca
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Cytomorphology of monomorphic spindle epithelial tumor with thymus‐like elements: A case with local recurrence after subtotal resection Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-23 Asma Arshia, Lame Balikani, Christine N. Booth
Spindle epithelial tumor with thymus‐like elements (SETTLE) is a rare biphasic thyroid tumor with low malignant potential that has a distinct morphology. Despite fine needle aspiration (FNA) being a common method for evaluating thyroid nodules and lymph nodes, there are limited cytologic descriptions of SETTLE in the literature due to its rarity. As a result, SETTLE is frequently underdiagnosed or
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Improving cervical cancer classification in PAP smear images with enhanced segmentation and deep progressive learning‐based techniques Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-22 Priyanka Mahajan, Prabhpreet Kaur
ObjectiveCervical cancer, a prevalent and deadly disease among women, comes second only to breast cancer, with over 700 daily deaths. The Pap smear test is a widely utilized screening method for detecting cervical cancer in its early stages. However, this manual screening process is prone to a high rate of false‐positive outcomes because of human errors. Researchers are using machine learning and deep
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Liquid biopsy of wash samples obtained via endoscopic ultrasound‐guided fine‐needle biopsy: Comparison with liquid biopsy of plasma in pancreatic cancer Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-22 Hiroshi Ohyama, Yosuke Hirotsu, Kenji Amemiya, Hiroyuki Amano, Sumio Hirose, Toshio Oyama, Yuji Iimuro, Yuichiro Kojima, Rintaro Mikata, Hitoshi Mochizuki, Naoya Kato, Masao Omata
ObjectivesPancreatic cancer (PC) has a poor prognosis and limited treatment options. Liquid biopsy, which analyzes circulating tumor DNA (ctDNA) in blood, holds promise for precision medicine; however, low ctDNA detection rates pose challenges. This study aimed to investigate the utility of wash samples obtained via endoscopic ultrasound‐guided fine‐needle biopsy (EUS‐FNB) as a liquid biopsy for PC
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Respond to “Comments on ‘Diagnostic models for predicting malignancy in thyroid nodules classified as Bethesda category III in an endemic region’” Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-20 Zeliha Aydın Kasap, Burçin Kurt, Elif Özsağır, Mustafa Emre Ercin, Ali Güner
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An isolated sacral promyelocytic sarcoma in a child: A rare case report with emphasis on cytomorphology Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-18 Jeongeun Do, Talal Arshad, Juanita Emily Ferreira, Leonard Nsoyori Yenwongfai, Hafsa Nebbache, Derek Blake Allison, Dava West Piecoro, Melissa Vandyke Kesler
Myeloid sarcoma (MS) is an uncommon localized extramedullary tumor composed of immature myeloid precursor cells that can affect any organ. Promyelocytic sarcoma (PS), an extremely rare subtype of MS, is characterized by immature myeloid cells with features of acute promyelocytic leukemia (APL). We describe a case of pediatric PS that presented as a solitary sacral mass without any evidence of systemic
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Comments on “diagnostic models for predicting malignancy in thyroid nodules classified as Bethesda category III in an endemic region” Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-16 Archit Goel, Gargi Kapatia, Shruti Gupta, Vikasdeep Gupta, Shivani Sidana
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Solitary fibrous tumor of deep parotid gland preoperatively classified as salivary gland neoplasm of uncertain malignant potential by the Milan system for reporting salivary gland cytopathology: A common diagnosis for a rare entity Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-16 Hamza Numan Gokozan, Theresa Scognamiglio
Solitary fibrous tumor (SFT) is a rare fibroblastic tumor with spindle cell morphology, which is characterized by a prominent branching vasculature and a NAB2‐STAT6 gene rearrangement. SFT may occur in any anatomical site and may involve salivary glands, including the parotid gland. We present a young female with a primary parotid SFT diagnosed as “neoplasm—Salivary gland neoplasm of uncertain malignant
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The American Board of Pathology cytopathology board examination: Personal recollections of the first cytopathology board exam and a brief historical perspective Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-13 George G. Birdsong
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Endometrial cytological findings for a mesonephric‐like endometrial adenocarcinoma: A case report Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-08 Hirotaka Omine, Kazuyuki Ishida, Natsuki Sasaki, Hikaru Kato, Tamiko Nagai, Mihoko Ishikawa, Mina Takaoka, Shuhei Noda, Hadzki Matsuda, Akira Mitsuhashi
A mesonephric‐like endometrial adenocarcinoma (ML‐EAC) is very rare and has a worse prognosis than other endometrial carcinomas. We describe an ML‐EAC and report our endometrial cytological findings. A 76‐year‐old woman presented with irregular genital bleeding and a uterine mass. Endometrial cytology revealed atypical cylindrical or spindle‐shaped cells in the form of small aggregates or solitary
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A case of lung FNA with atypical squamous cells Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-04 Timothy Leif Helland, Vanda F. Torous
Fine‐needle aspiration (FNA) is a commonly employed method for initial diagnosis and work‐up of pulmonary nodules. Utilization of rapid on‐site evaluation (ROSE) has the added benefit of allowing for triaging of material as appropriate for ancillary studies including microbiology testing. While many pulmonary lesions are easily categorized by cytologic evaluation, more difficult cases exist. In particular
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Unveiling lipid‐rich (“clear cell”) pancreatic neuroendocrine tumor: A small series of two cases with literature review Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-03-01 Rong Xia, Laura H. Tang, Negin Shafizadeh, Yue Xue, Xiaoying Liu
This study presents two cases of lipid‐rich pancreatic neuroendocrine tumors (PanNETs), a rare variant posing significant diagnostic challenges in fine needle aspiration (FNA) cytology and small biopsies. The first case involves an elderly male with a pancreatic tumor, displaying distinct cytoplasmic vacuoles, while the second case is a middle‐aged male present with a pancreatic tail mass exhibiting
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Fine‐needle aspiration diagnosis of secondary malignant tumors of the thyroid gland: A single‐institution experience of 17 cases Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-28 Wei Zhang, Jianyuan Lei, Jie Chen, Wensheng Li
BackgroundFine‐needle aspiration (FNA) is the most commonly used preoperative pathological diagnostic tool for thyroid tumors. Secondary malignant tumors of the thyroid gland account for less than 3% of all thyroid malignancies. The aim of this study was to investigate the types and cytopathological features of secondary thyroid tumors, evaluate diagnostic pitfalls in FNA.MethodsCases of secondary
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Case of lung fine needle aspiration showing mucinous cells and extracellular mucin Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-27 Maelle Saliba, Marie C. Smithgall, Anjali Saqi, John P Crapanzano, Simon Sung
Mucinous neoplasm with extracellular mucin can be challenging to interpret on fine needle aspiration and core biopsies. Determining the biologic origin of the mucin/mucinous cells, that is, benign/incidental versus neoplasm, invasive versus in situ, and primary versus metastatic tumors, requires a thorough multidisciplinary evaluation. The work up of these lesions includes morphologic analysis with
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Metastatic upper tract urothelial carcinoma with nest-like features presenting as malignant pleural effusion Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-23 Francesca Arienzo, Alessandra Valenti, Paolo Ricci, Valeria Ascoli
Metastatic urothelial carcinoma is a rare cause of pleural effusions. We report a case of urothelial carcinoma of the upper urinary tract in an oldest-old male patient, a smoker, with situs inversus totalis, that presented uniquely with malignant pleural effusion at presentation without evidence of a primary tumor on imaging. Cytological smears of the massive left pleural effusion revealed epithelioid
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Gastrointestinal stromal tumors in fine-needle aspiration biopsies Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-23 Seyedreza Mousavi, Yuho Ono, Paul A. VanderLaan, Yaileen D. Guzmán-Arocho
Gastrointestinal stromal tumors (GISTs), although rare, are the most common mesenchymal neoplasms of the gastrointestinal tract. Their potential for malignancy underscores the significance of identifying them through cytomorphologic findings and pertinent immunohistochemical markers. GISTs can emerge anywhere along the gastrointestinal tract with a predilection for the stomach. The clinical manifestations
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Cytomorphology of metastatic dedifferentiated/undifferentiated melanoma to the gallbladder: A case report and review of literature Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-21 Shaymaa Hegazy, Zarine Kamaluddin, Rana Naous
Dedifferentiated/undifferentiated melanoma (DM/UM) is a distinct subtype of malignant melanoma that tends to lose all melanocytic markers of differentiation. DM/UM pose major diagnostic challenges as they could be easily confused with UM sarcoma or carcinoma, thus necessitating the use of molecular studies such as Next Generation Sequencing (NGS) for detecting melanoma-compatible mutations to confirm
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Are there specific cytologic features that can predict BRAFV600E mutational status of papillary thyroid carcinoma in fine‐needle aspiration specimens? Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-19 Juliann M. Mendes, Tarik M. Elsheikh, Jessica Di Marco, Jennifer Russell, Tatyana Gladkaya, Marlo M. Nicolas, Elisha Clapacs, James F. Bena, John L. McAfee, Maria Luisa C. Policarpio‐Nicolas
BackgroundBRAFV600E mutation is the most common molecular alteration found in papillary thyroid carcinoma (PTC) and has been linked to recurrent disease or possibly more aggressive behavior. Some studies have reported sickle‐shaped nuclei (SSN) and plump pink cells (PPC) to be predictive markers of BRAF mutation in FNA cytology. We aimed to evaluate the reproducibility of the aforementioned cytologic
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AIns (insulin) type amyloidoma of the extremity diagnosed by fine-needle aspiration Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-17 Nisha S. Ramani, Rhea A. Morani, Bhuvaneswari Krishnan
Amyloid is an extracellular deposition of Congo red positive material which shows apple green birefringence under polarized light. A cytopathologist can uncommonly encounter such cases. Among the reported cases, a fine-needle aspiration (FNA) of amyloid is frequently misinterpreted as acellular nondiagnostic material. We report a case of amyloidoma of the right upper arm in a 68-year-old man with history
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Calcium oxalate crystals in pulmonary aspergillosis Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-17 Gonçalo Martins Pereira, Miguel Cristóvão, Eugénia Dvindenko, Carla Pinheiro, Maria Manuel Lemos, Saudade André
CONFLICT OF INTEREST STATEMENT None of the authors have conflicts of interest to declare.
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Myxoid neurofibroma masquerading as lymphatic-venous malformation and poses a diagnostic challenge on fine needle aspiration biopsy Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-16 Nada Shaker, Hans Iwenofu, Nuha Shaker, Zofia Tynski, Omar P. Sangueza, Abdul Abid
Myxoid neurofibromas (NF) are uncommon, benign spindle cell tumors that originate from peripheral nerve sheaths, often posing a diagnostic challenge due to their hypocellularity on cytology specimens. Distinguishing myxoid spindle cell lesions can be challenging, given the broad range of potential differential diagnoses.
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Accuracy of endobronchial ultrasound-guided transbronchial needle aspiration for staging of non-small cell lung cancer Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-13 Kimberley Chung, Jacqueline Bentel, Andrew Laycock
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is routinely performed to confirm a lung cancer diagnosis and/or to clinically stage disease. EBUS-TBNA findings may be used to determine whether patients can be offered potentially curative surgery. In this study, we evaluated the reporting in our service of EBUS-TBNA cytology for early-stage (operable) non-small cell lung
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Synchronous hepatocellular carcinoma and renal cell carcinoma: A cytological marvel Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-13 Sivaranjani Selvaraj, Priya Dharmalingam, Soumya Alashetty, Usha Amirtham
Multiple primary synchronous tumours have always created an inquisitiveness among clinicians, radiologists and pathologists. The diagnosis invariably proposes a challenge to diagnosticians. The coexistence of a primary hepatocellular carcinoma (HCC) and renal cell carcinoma (RCC) is exceedingly rare, with countable number of cases being reported in literature. We report a pioneer case of 75-year-old
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Fungal infection mimicking soft tissue lesion: Role of on-site evaluation, special stain, and cellblock Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-13 Santosh Tummidi, Micheal Leonard Anthony, Jarang Rajesh Kumar, Arundhathi Shankaralinagappa, Naresh Kumar Pannerselvam, Prudhvinath A Reddy, Pavithra Balakrishna
Fine-needle aspiration (FNA) cytology is a basic diagnostic method used for the investigation of superficial and deep lesions. The implementation of rapid on-site evaluation (ROSE) in cytological analysis can help in reducing the inadequacy rate and obtaining proper samples for further tests/analysis.
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Insufficient endobronchial ultrasound-guided transbronchial needle aspiration specimens. When and why? The analysis of criteria and reasons behind the insufficient specimens Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-13 Antti Vuorisalo, Heini Huhtala, Timo Paavonen, Ivana Kholová
The classification terminology systems for pulmonary cytology specimens have recently emerged. Inadequate samples, classified as "nondiagnostic," raise challenges in determining the threshold of cell numbers and the risk of malignancy (ROM).
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Fusion of old and new: Employing touch imprint slides for next generation sequencing in solid tumors Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-09 Cisel Aydin Mericoz, Ozgur Can Eren, Ibrahim Kulac, Pinar Firat
Cytomorphological evaluation of tissue touch imprints during rapid on-site evaluation or intraoperative pathology consultation has crucial value. However, literature on their utility for molecular testing is limited. In this study, we emphasize a further benefit of touch imprint slides and scrutinize our institutional experience on their use in molecular testing, specifically next generation sequencing
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COVID and cytopathology training: Impact and innovations Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-07 Kasturi Das
Graduate medical education and training in Cytopathology faced numerous unexpected challenges during the COVID-19 pandemic of 2020. It was caused by the SARS-Co-V2 coronavirus and transmitted by breathing droplets or aerosol particles containing the virus and less commonly by contact with infected surfaces and fomites. To mitigate the rapid spread of disease non-essential services were closed, surgical
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Cytotechnology schools: Future outlook Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-02-03 Lois Rockson
Recent changes in the standard and guidelines governing the education of cytotechnologists herald in a new era of cytology education. The long-discussed move to master level education and name change of the professional to cytologist signifies an alignment with current and projected scope of mid-level diagnostic cytology practice. Cytotechnology programs going forward are charged with implementing
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Endometriosis first presenting in pleural fluid cytology Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-01-30 Heather I. Chen-Yost, Tao Huang, Kathleen O'Brien, William Weir, Rishindra M. Reddy, Richard Lieberman, Judy Pang
Most patients with thoracic endometriosis present with catamenial pneumothorax, a rare condition in which recurrent episodes occur within 72 h before or after the start of menstruation. We report a case of thoracic endometriosis presenting with recurrent bloody pleural effusions without pneumothorax diagnosed on pleural fluid cytology. We describe the cytomorphology and immunoprofile of thoracic endometriosis
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Trichilemmal carcinoma metastatic to parotid gland: First report of fine needle aspiration cytology features Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-01-29 Priya Jayakumar, Aanchal Kakkar, Sudheer Arava, Supriya Mallick
Trichilemmal carcinoma is a rare malignant cutaneous adnexal neoplasm arising from the outer root sheath of the hair follicle. Majority of cases occur on sun-exposed sites such as the face, scalp and neck, making them easily amenable to being biopsied and subjected to histological examination for definitive diagnosis. Thus, cytological features of trichilemmal carcinoma have not been described till
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Diagnostic models for predicting malignancy in thyroid nodules classified as Bethesda Category III in an endemic region Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-01-25 Zeliha Aydın Kasap, Burçin Kurt, Elif Özsağır, Mustafa Emre Ercin, Ali Güner
This study aims to develop a diagnostic model to help physicians determine whether thyroid nodules categorized as atypia of undetermined significance (AUS) in category III of the Bethesda system are benign or malignant preoperatively. To create a diagnostic model for predicting thyroid nodules' benign or malignant with AUS cytology based on clinical, ultrasonographic, and cytopathological findings
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The detection of PD-L1 expression on liquid-based cytology in pleural effusion of lung adenocarcinoma and its prognostic evaluation: Between paired liquid-based cytology and cell block samples Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-01-23 Haiyue Ma, Jia Jia, Zihan Sun, Xiaoyue Xiao, Shuo Liang, Linlin Zhao, Zhihui Zhang
Programmed death-ligand 1 (PD-L1) expression levels measured by immunohistochemistry have been proven to predict the outcome of immunotherapy in lung adenocarcinoma (LUAD). However, data on PD-L1 expression on liquid-based cytology (LBC) in malignant pleural effusion (MPE) is scarce.
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Rapid on-site evaluation improves diagnostic performance of fine-needle aspiration cytology for salivary lesions: Comparison of data from two cancer centers in southern China Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-01-23 Manbin Xu, Lifei Deng, Kunpeng Peng, Xiaolong Wei, Mei Xie, Muyuan Liu, Hanwei Peng
To evaluate the diagnostic performance of Milan system for reporting salivary gland cytopathology (MSRSGC) in two southern China tertiary cancer centers and investigate the impact of rapid on-site evaluation (ROSE) on FNAC performance.
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Investigation of MTAP and BAP1 staining loss and P16/CDKN2A deletion in pleural cytology specimens and its role in the diagnosis of mesothelioma Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-01-20 Nazli Sena Şeker, Emel Tekin, Güntülü Ak, Muzaffer Metintaş, Selma Metintaş, Emine Dündar
Mesothelioma is a malignant neoplasm with a poor survival rate. We aimed to investigate the importance of BAP1, MTAP (IHC), and p16/CDKN2A homozygous deletion (FISH) in cytologic material obtained from pleural effusion sampling, which is a less invasive procedure in the diagnosis of mesothelioma.
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Cytohistological findings and diagnostic challenges in rare pediatric pulmonary mesenchymal malignancies: A report of two cases Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-01-18 Karunagaran Balaji, Swalaha Sadaf Siddique, Ujjawal Khurana, Garima Goel, Ashwani Tandon, Deepti Joshi, Narendra Chaudhary, Alkesh Kumar Khurana, Abhishek Goyal
Pulmonary mesenchymal tumors are uncommon neoplasms and the data available on their clinical, cytohistomorphological, immunohistochemical, and molecular findings are limited, leading to difficulty in timely diagnosis and management. Case 1: A 12-year-old boy presented with a right endobronchial mass. Imprint smears from endobronchial biopsy revealed moderately pleomorphic spindle cell tumor arranged
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Fine needle aspiration of spindle cell lipoma—Lochkern cells as a clue for diagnosis: A case arising in the parotid gland Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-01-12 Mana Taweevisit, Paul Scott Thorner
Spindle cell lipoma (SCL) is a rare form of lipoma, typically occurring as a mass in the back, shoulder or posterior neck of adult males. Most cases present little diagnostic difficulty on fine needle aspiration (FNA), but can be problematic when the SCL is in an unusual location. The authors report a case in the parotid gland in a 75-year-old man. FNA was paucicellular and showed loose collections
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Cytomorphological comparison of ThinPrep and SurePath liquid-based cytology in thyroid fine-needle aspiration Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-01-12 Wen-Ying Lee, Hsiu-Chu Wang, Kai-Jen Tien
The two widely established systems for liquid-based cytology (LBC), ThinPrep and SurePath, employ different principles. The aim of this study was to compare the cytomorphology of thyroid lesions prepared by the two techniques.
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A comparison between conventional and the Paris systems of reporting urinary cytopathology with a literature update Diagn. Cytopathol. (IF 1.3) Pub Date : 2024-01-02 Narasimhapriyan Kannan, Debasis Gochhait, Manikandan Ramanitharan, Neelaiah Siddaraju
Owing to certain inherent limitations of earlier reporting systems, “The Paris System for Reporting Urinary Cytology (TPS)” was implemented in 2015 to standardize reporting urine cytology with more stringent cytomorphologic criteria. We share our post-TPS experience, comparing it with the conventional system (CS).
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Gastric-type adenocarcinoma of the uterine cervix presenting in urine cytology specimens: A case report and literature review Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-12-22 Kyung-Hwa Lee, Nah Ihm Kim, Jong-Hee Nam, Sung Sun Kim
Gastric-type endocervical adenocarcinoma (GEA) is a rare type adenocarcinoma of the uterine cervix that is unrelated to human papillomavirus (HPV). GEA is difficult to diagnose due to its bland-looking morphological characteristics and is therefore often underdiagnosed. Although abnormal cells may be seen on cervical cytology specimens, they are rarely diagnosed as malignant and are often classified
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Performance of non-formalin fixed paraffin embedded samples in hybrid capture and amplicon next-generation sequencing panels Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-12-20 Sibele Inácio Meireles, Mariana Vargas Cruz, Carla Daniele de Godoy, Leonardo de Testagrossa
Genomic profiling using next-generation sequencing (NGS) is fundamental for driving prognostic and therapy in cancer. Formalin-fixed paraffin embedded (FFPE) tissue is the widely used material, whereas non-FFPE may represent an alternative. However, studies comparing the NGS performance of non-FFPE materials to FFPE are still lacking in the literature. The objective of this study was to characterize
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Disseminated thymoma in pleural fluid: An unusual case Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-12-16 Kate Berry, Caroline Cooper
Thymic epithelial tumours show characteristic cytological features on fine-needle aspiration cytology, however the cytological features of thymoma in fluid cytology are not well described. We present the case of a 77 year-old-woman with known pleural dissemination of type B2/B3 thymoma presenting with shortness of breath and orthopnoea due to a pleural effusion. Cytological evaluation of the pleural
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PD-L1 expression in fine-needle aspiration cell blocks of head and neck squamous-cell carcinoma and its cytohistological concordance Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-12-14 Sandy Si Kei Lou, Heather Ruff, Scott MacDonald, Stephen M. Smith, Carol C. Cheung
PD-L1 immunoexpression in head and neck squamous-cell carcinoma (HNSCC) determines immunotherapy eligibility. Patients are often diagnosed using fine-needle aspiration (FNA) of metastatic lymph nodes, however, the cytohistologic correlation of the combined positive score (CPS) is largely unknown.
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Two-tier subclassification of the Bethesda category III (atypia of undetermined significance/follicular lesion of undetermined significance) in thyroid cytology Diagn. Cytopathol. (IF 1.3) Pub Date : 2023-12-14 Jay Alden, Denise Lambrou, Jack Yang
The Bethesda category III, AUS/FLUS, comprises a heterogeneous group of thyroid lesions with variable risk of malignancy (ROM). This study evaluates ROM in two subgroups of this category based on nuclear atypia and architectural atypia.