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The Cross Talk between Cancer Stem Cells/Cancer Initiating Cells and Tumor Microenvironment: The Missing Piece of the Puzzle for the Efficient Targeting of these Cells with Immunotherapy. Cancer Microenviron. Pub Date : 2019-11-22 Shilpa Ravindran,Saad Rasool,Cristina Maccalli
Cancer Stem Cells/Cancer Initiating Cells (CSCs/CICs) is a rare sub-population within a tumor that is responsible for tumor formation, progression and resistance to therapies. The interaction between CSCs/CICs and tumor microenvironment (TME) can sustain “stemness” properties and promote their survival and plasticity. This cross-talk is also pivotal in regulating and modulating CSC/CIC properties.
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Cross-Talk Between circRNAs and mRNAs Modulates MiRNA-mediated Circuits and Affects Melanoma Plasticity. Cancer Microenviron. Pub Date : 2019-11-16 Maria Rita Fumagalli,Maria Chiara Lionetti,Stefano Zapperi,Caterina A M La Porta
CircularRNAs (circRNAs) are non-coding RNAs which compete for microRNA (miRNA) binding, influencing the abundance and stability of other RNA species. Herein we have investigated the effect of circRNAs on the mir200-ZEB1 feedback loop in relationship with the aggressiveness of human melanoma cells. We first compared the level of expression of key factors in the mir200-ZEB1 feedback loop in primary human
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The Concomitant Expression of Human Endogenous Retroviruses and Embryonic Genes in Cancer Cells under Microenvironmental Changes is a Potential Target for Antiretroviral Drugs. Cancer Microenviron. Pub Date : 2019-11-05 Alessandro Giovinazzo,Emanuela Balestrieri,Vita Petrone,Ayele Argaw-Denboba,Chiara Cipriani,Martino Tony Miele,Sandro Grelli,Paola Sinibaldi-Vallebona,Claudia Matteucci
In our genomes there are thousands of copies of human endogenous retroviruses (HERVs) originated from the integration of exogenous retroviruses that infected germ line cells millions of years ago, and currently an altered expression of this elements has been associated to the onset, progression and acquisition of aggressiveness features of many cancers. The transcriptional reactivation of HERVs is
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8th International conference on Tumor Microenvironment, Lisbon, Portugal June 10-14, 2018. Cancer Microenviron. Pub Date : 2018-05-21 Pedro Baleia
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Matrix Metalloproteinase 8: Could it Benefit the CAR-T Cell Therapy of Solid Tumors?- a- Commentary on Therapeutic Potential. Cancer Microenviron. Pub Date : 2018-03-29 Alireza Mardomi,Saeid Abediankenari
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Erratum to: Separation and Characterization of Epithelial and Mesenchymal-like Murine Mammary Tumor Cells Reveals Epithelial Cell Differentiation Plasticity and Enhanced Tumorigenicity of Epithelial-enriched Tumor Cells. Cancer Microenviron. Pub Date : 2016-01-10 Katie A Palen,Weiqing Jing,James J Weber,Sara B Tilkens,Andrew M Chan,Bryon D Johnson,Jill A Gershan
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Tumor-Infiltrating Immunosuppressive Cells in Cancer-Cell Plasticity, Tumor Progression and Therapy Response. Cancer Microenviron. Pub Date : 2019-10-03 Laura Lorenzo-Sanz,Purificación Muñoz
In most tumors, cancer cells show the ability to dynamically transit from a non-cancer stem-like cell to a cancer stem-like cell (CSC) state and vice versa. This cell plasticity has been associated with the epithelial-to-mesenchymal transition program (EMT) and can be regulated by tumor cell-intrinsic mechanisms and complex interactions with various tumor microenvironment (TME) components. These interactions
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Kinins in Glioblastoma Microenvironment. Cancer Microenviron. Pub Date : 2019-08-16 Mona N Oliveira,Barbara Breznik,Micheli M Pillat,Ricardo L Pereira,Henning Ulrich,Tamara T Lah
Tumour progression involves interactions among various cancer cell clones, including the cancer stem cell subpopulation and exogenous cellular components, termed cancer stromal cells. The latter include a plethora of tumour infiltrating immunocompetent cells, among which are also immuno-modulatory mesenchymal stem cells, which by vigorous migration to growing tumours and susequent transdifferentiation
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Pleiotropic Effects of Epithelial Mesenchymal Crosstalk on Head and Neck Cancer: EMT and beyond. Cancer Microenviron. Pub Date : 2019-07-11 T B Steinbichler,D Savic,D Dejaco,A Romani,B Kofler,I I Skvortsova,H Riechelmann,J Dudas
Epithelial mesenchymal crosstalk (EMC) describes the interaction of the tumor stroma and associated fibroblasts with epithelial cancer cells. In this study we analysed the effects of EMC on head and neck cancer cells. In tumor cell lines EMC was induced using media conditioned from a mix-culture of cancer cells and fibroblasts. Cell proliferation and chemotherapy response were assessed using direct
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Ascites from Ovarian Cancer Induces Novel Fucosylated Proteins. Cancer Microenviron. Pub Date : 2019-07-02 Dulce Rosario Alberto-Aguilar,Verónica Ivonne Hernández-Ramírez,Juan Carlos Osorio-Trujillo,Dolores Gallardo-Rincón,Alfredo Toledo-Leyva,Patricia Talamás-Rohana
Ovarian cancer is considered to be the most lethal type of gynecological cancer. During the advanced stages of ovarian cancer, an accumulation of ascites is observed. Fucosylation has been classified as an abnormal post-translational modification that is present in many diseases, including ovarian cancer. Ovarian cancer cells that are cultured with ascites stimulation change their morphology; concomitantly
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Pyruvate Kinase M2: a Metabolic Bug in Re-Wiring the Tumor Microenvironment. Cancer Microenviron. Pub Date : 2019-06-10 Mohd Rihan,Lakshmi Vineela Nalla,Anil Dharavath,Amit Shard,Kiran Kalia,Amit Khairnar
Metabolic reprogramming is a newly emerged hallmark of cancer attaining a recent consideration as an essential factor for the progression and endurance of cancer cells. A prime event of this altered metabolism is increased glucose uptake and discharge of lactate into the cells surrounding constructing a favorable tumor niche. Several oncogenic factors help in promoting this consequence including, pyruvate
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Immunosuppressive Tumor Microenvironment Status and Histological Grading of Endometrial Carcinoma. Cancer Microenviron. Pub Date : 2019-05-27 Julie Antomarchi,Damien Ambrosetti,Charlotte Cohen,Jérôme Delotte,Anne Chevallier,Babou Karimdjee-Soilihi,Mélanie Ngo-Mai,Annie Schmid-Alliana,Heidy Schmid-Antomarchi
The recent successes of new cancer immunotherapy approaches have led to investigate their relevance in the context of the Endometrial Carcinoma (EC). These therapies, that take the tumor-induced immunosuppressive microenvironment into account, target the tumor immune escape, in particular the inhibitory receptors involved in the regulation of the effector T cells’ activity (immune checkpoints). The
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Targeting Hyaluronan Interactions for Glioblastoma Stem Cell Therapy. Cancer Microenviron. Pub Date : 2019-05-11 Joline S Hartheimer,Seungjo Park,Shreyas S Rao,Yonghyun Kim
Even with rigorous treatments, glioblastoma multiforme (GBM) has an abysmal median survival rate, greatly due to the drug-resistant glioblastoma stem cell (GSC) population. GSCs are known to remodel their microenvironment, but the precise role of extracellular matrix components hyaluronic acid (HA) and hyaluronidases (HAases) on the GSC population is still largely unknown. Our objective was to determine
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Cancer-Associated Fibroblasts Enhance Survival and Progression of the Aggressive Pancreatic Tumor Via FGF-2 and CXCL8. Cancer Microenviron. Pub Date : 2019-04-26 Mohammad Awaji,Mitsuru Futakuchi,Tayla Heavican,Javeed Iqbal,Rakesh K Singh
Pancreatic ductal adenocarcinoma remains one of the most challenging human cancers. Desmoplasia is predominant in this disease exhibiting a strong stromal reaction with an abundance of the cancer-associated fibroblasts (CAFs). We aimed in this study to investigate the reciprocal interaction between the tumor cells and the CAFs and its effect on tumor cells survival. We hypothesized that the survival
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Mechanobiology of Cancer Stem Cells and Their Niche. Cancer Microenviron. Pub Date : 2019-04-19 Ankit Roy Choudhury,Surabhi Gupta,Pradeep Kumar Chaturvedi,Neeraj Kumar,Deepak Pandey
Though the existence of cancer stem cells remained enigmatic initially, over the time their participation in tumorigenesis and tumor progression has become highly evident. Today, they are also appreciated as the causal element for tumor heterogeneity and drug-resistance. Cancer stem cells activate a set of molecular pathways some of which are triggered by the unique mechanical properties of the tumor
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Altered T Cell Migratory Capacity in the Progression from Barrett Oesophagus to Oesophageal Adenocarcinoma. Cancer Microenviron. Pub Date : 2019-03-04 Maria E Kavanagh,Melissa J Conroy,Niamh E Clarke,Niamh T Gilmartin,Ronan Feighery,Finbar MacCarthy,Dermot O'Toole,Narayanasamy Ravi,John V Reynolds,Jacintha O' Sullivan,Joanne Lysaght
Oesophageal adenocarcinoma (OAC) is an inflammation-driven cancer with poor prognosis and incidence is increasing rapidly. OAC arises from gastro-oesophageal reflux disease (GORD) and reflux-induced Barrett oesophagus (BO). The role of T cells in this disease progression is not yet fully understood. We have previously demonstrated higher proportions of pro-tumour Th2 cells in BO tissue, implicating
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The Tumor Microenvironment in Post-Transplant Lymphoproliferative Disorders. Cancer Microenviron. Pub Date : 2019-01-24 Lukas Marcelis,Thomas Tousseyn
Post-transplant lymphoproliferative disorders (PTLDs) cover a broad spectrum of lymphoproliferative lesions arising after solid organ or allogeneic hematopoietic stem cell transplantation. The composition and function of the tumor microenvironment (TME), consisting of all non-malignant constituents of a tumor, is greatly impacted in PTLD through a complex interplay between 4 factors: 1) the graft organ
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Hypoxia Induces the Acquisition of Cancer Stem-like Phenotype Via Upregulation and Activation of Signal Transducer and Activator of Transcription-3 (STAT3) in MDA-MB-231, a Triple Negative Breast Cancer Cell Line. Cancer Microenviron. Pub Date : 2018-09-25 Hoda Soleymani Abyaneh,Nidhi Gupta,Abdulraheem Alshareef,Keshav Gopal,Afsaneh Lavasanifar,Raymond Lai
The finding that hypoxia can induce cancer stemness in various experimental models is in agreement with the conceptual basis of cancer cell plasticity. Here, we aimed to gain insights into the molecular basis of hypoxia-induced cancer cell plasticity in triple negative breast cancer (TNBC). To achieve this goal, we employed our previously published in-vitro model of TNBC, in which a small subset of
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T-Cell Clustering in Neoplastic Follicles of Follicular Lymphoma. Cancer Microenviron. Pub Date : 2018-09-11 Patrick Schnotalle,Karoline Koch,Rex K H Au-Yeung,Sarah Reinke,Karsten Winter,Markus Loeffler,Ulf-Dietrich Braumann,Wolfram Klapper
The nonneoplastic microenvironment is abundant in follicular lymphoma. Its composition has been reported to be associated with the course of the disease. Lack of animal models hampers studies of interaction between lymphoma and bystander cells. We aimed to identify indicators of cellular interaction exemplified by nonrandom distribution of cell types within neoplastic follicles. Physiological germinal
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Cerebrospinal Fluid Hyaluronan and Neurofibromatosis Type 2. Cancer Microenviron. Pub Date : 2018-08-25 Prasanth S Ariyannur,Narendranath Vikkath,Ashok B Pillai
Neurofibromatosis type 2 (NF-2) is associated with mainly three types of recurrent benign tumors restricted to the central nervous system: schwannoma, meningioma and ependymoma. The absence of the protein NF2/Merlin causes an uninterrupted cell proliferation cascade originating from an abnormal interaction between an extracellular mucopolysaccharide, hyaluronan (HA), and schwann cell surface CD44 receptor
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Skewed Signaling through the Receptor for Advanced Glycation End-Products Alters the Proinflammatory Profile of Tumor-Associated Macrophages. Cancer Microenviron. Pub Date : 2018-08-08 Armando Rojas,Paulina Araya,Jacqueline Romero,Fernando Delgado-López,Ileana Gonzalez,Carolina Añazco,Ramon Perez-Castro
Tumors are complex tissues composed of variable amounts of both non-cellular components (matrix proteins) and a multitude of stromal cell types, which are under an active cross-talk with tumor cells. Tumor-associated macrophages (TAMs) are the major leukocyte population among the tumor-infiltrating immune cells. Once they are infiltrated into tumor stroma they undergo a polarized activation, where
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Ascites IL-10 Promotes Ovarian Cancer Cell Migration. Cancer Microenviron. Pub Date : 2018-07-23 Denis Lane,Isabelle Matte,Perrine Garde-Granger,Paul Bessette,Alain Piché
Ovarian cancer (OC) ascites is an inflammatory and immunosuppressive tumor environment characterized by the presence of various cytokines, chemokines and growth factors. The presence of high concentrations of these cytokines/chemokines in ascites is associated with a more aggressive tumor phenotype. IL-10 is an immunosuppressive cytokine for which high expression has been associated with poor prognosis
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Tumor-Associated T-Lymphocytes and Macrophages are Decreased in Endometrioid Endometrial Carcinoma with MELF-Pattern Stromal Changes. Cancer Microenviron. Pub Date : 2018-07-14 Dmitry Aleksandrovich Zinovkin,Md Zahidul Islam Pranjol,Il'ya Andreevich Bilsky,Valeriya Alexandrovna Zmushko
Microcystic, elongated, fragmented (MELF)-pattern is an unusual morphology of myometrial invasive front in endometrioid endometrial carcinoma (EA). The aim of the study was to investigate potential correlation between MELF-pattern and peritumoral inflammatory immune response. A total of 96 out of 368 patients were included in this study. CD3, CD20, CD57. CD68 and S100 markers were used for the detection
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Exosomes: Definition, Role in Tumor Development and Clinical Implications. Cancer Microenviron. Pub Date : 2018-05-03 Alberto Carretero-González,Irene Otero,Lucía Carril-Ajuria,Guillermo de Velasco,Luis Manso
Exosomes are microvesicles released by cells in both physiological and pathological situations. They are surrounded by a lipid bilayer with proteins derived from the origin cell, and contain a variety of molecules, such as nucleic acids. They represent an emerging mechanism of intercellular communication, and they play an important role in the pathogenesis of cancer, stimulating proliferation and aggressiveness
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The Influence of Breast Tumour-Derived Factors and Wnt Antagonism on the Transformation of Adipose-Derived Mesenchymal Stem Cells into Tumour-Associated Fibroblasts. Cancer Microenviron. Pub Date : 2018-04-10 Malini Visweswaran,Kevin N Keane,Frank Arfuso,Rodney J Dilley,Philip Newsholme,Arun Dharmarajan
Within the tumour stroma, a heterogeneous population of cell types reciprocally regulates cell proliferation, which considerably affects the progression of the disease. In this study, using tumour conditioned medium (TCM) derived from breast tumour cell lines – MCF7 and MDA MB 231, we have demonstrated the differentiation of adipose-derived mesenchymal stem cells (ADSCs) into tumour-associated fibroblasts
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Peripheral Blood Cell Interactions of Cancer-Derived Exosomes Affect Immune Function. Cancer Microenviron. Pub Date : 2018-03-30 Heather R Ferguson Bennit,Amber Gonda,James R W McMullen,Janviere Kabagwira,Nathan R Wall
Cancer-derived exosomes are constitutively produced and secreted into the blood and biofluids of their host patients providing a liquid biopsy for early detection and diagnosis. Given their ubiquitous nature, cancer exosomes influence biological mechanisms that are beneficial to the tumor cells where they are produced and the microenvironment in which these tumors exist. Accumulating evidence suggests
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Role of the Nervous System in Tumor Angiogenesis. Cancer Microenviron. Pub Date : 2018-03-04 Nyanbol Kuol,Lily Stojanovska,Vasso Apostolopoulos,Kulmira Nurgali
The development of cancer involves an intricate process, wherein many identified and unidentified factors play a role. Tumor angiogenesis, growth of new blood vessels, is one of the major prerequisites for tumor growth as tumor cells rely on adequate oxygen and nutrient supply as well as the removal of waste products. Growth factors including VEGF orchestrate the development of angiogenesis. In addition
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Extracellular ATP is Differentially Metabolized on Papillary Thyroid Carcinoma Cells Surface in Comparison to Normal Cells. Cancer Microenviron. Pub Date : 2018-02-17 Ana Paula Santin Bertoni,Rafael Paschoal de Campos,Marisa Tsao,Elizandra Braganhol,Tania Weber Furlanetto,Márcia Rosângela Wink
The incidence of differentiated thyroid cancer has been increasing. Nevertheless, its molecular mechanisms are not well understood. In recent years, extracellular nucleotides and nucleosides have emerged as important modulators of tumor microenvironment. Extracellular ATP is mainly hydrolyzed by NTPDase1/CD39 and NTPDase2/CD39L1, generating AMP, which is hydrolyzed by ecto-5′-nucleotidase (CD73) to
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Recovery of Immunoglobulin VJ Recombinations from Pancreatic Cancer Exome Files Strongly Correlates with Reduced Survival. Cancer Microenviron. Pub Date : 2018-02-05 Jacob C Kinskey,Yaping N Tu,Wei Lue Tong,John M Yavorski,George Blanck
We assessed pancreatic cancer, lymphocyte infiltrates with a computational genomics approach. We took advantage of tumor-specimen exome files available from the cancer genome atlas to mine T- and B-cell immune receptor recombinations, using highly efficient, scripted algorithms established in several previous reports. Surprisingly, the results indicated that pancreatic cancer exomes represent one of
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Immunogenomics: A Negative Prostate Cancer Outcome Associated with TcR-γ/δ Recombinations. Cancer Microenviron. Pub Date : 2018-01-22 Yaping N Tu,Wei Lue Tong,John M Yavorski,George Blanck
We developed a scripted algorithm, based on previous, earlier editions of the algorithm, to mine prostate cancer exome files for T-cell receptor (TcR) recombination reads: Reads representing TcR gene recombinations were identified in 497 prostate cancer exome files from the cancer genome atlas (TCGA). As has been reported for melanoma, co-detection of productive TcR-α and TcR-β recombination reads
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Positive Correlation between Matrix Metalloproteinases and Epithelial-to-Mesenchymal Transition and its Association with Clinical Outcome in Bladder Cancer Patients. Cancer Microenviron. Pub Date : 2018-01-18 R Singh,A Mandhani,V Agrawal,Minal Garg
Involvement of matrix metalloproteinases (MMPs) in the pathogenesis of urothelial carcinoma elects them to be sensitive marker for clinical and prognostic implications. MMPs regulate tumor growth and invasion by inducing epithelial-to-mesenchymal transition (EMT) which is characterized by the complex reprogramming of epithelial cells and ultimately bring about major changes in the structural organization
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Three-Dimensional Cellular Arrangement in Epithelial Ovarian Cancer Cell Lines TOV-21G and SKOV-3 is Associated with Apoptosis-Related miRNA Expression Modulation. Cancer Microenviron. Pub Date : 2018-01-06 Aline Brito de Lima,Luciana Maria Silva,Nikole Gontijo Gonçales,Maria Raquel Santos Carvalho,Agnaldo Lopes da Silva Filho,Letícia da Conceição Braga
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, and the lack of chemoresistance biomarkers contributes to the poor prognosis. Cancer stem cells (CSC) have been investigated in EOC to understand its relationship with chemoresistance and recurrence. In this context, in vitro cultivation-models are important tools for CSC studies. MicroRNAs (miRNAs) play key roles in cancer
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SR 11302, an AP-1 Inhibitor, Reduces Metastatic Lesion Formation in Ex Vivo 4D Lung Cancer Model. Cancer Microenviron. Pub Date : 2017-11-24 Dhruva Kumar Mishra,Min P Kim
Activator protein (AP) -1 is a transcription factor, plays important role in cell differentiation, proliferation and apoptosis. Analysis of tumor cells grown on ex vivo 4D lung cancer model shows increase in components of AP-1, c-Fos and c-Jun in circulating tumor cells (CTC) compared to primary tumor. Our aim was to determine whether the AP-1 inhibitor SR11302 reduces metastatic lesion formation in
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Prognostic Prediction of Oral Squamous Cell Carcinoma by E-Cadherin and N-Cadherin Expression in Overall Cells in Tumor Nests or Tumor Cells at the Invasive Front. Cancer Microenviron. Pub Date : 2017-11-02 Yuu Ozaki-Honda,Sachiko Seki,Mutsunori Fujiwara,Masaaki Matsuura,Shuichi Fujita,Hisazumi Ikeda,Masahiro Umeda,Takao Ayuse,Tohru Ikeda
Epithelial-mesenchymal transition (EMT) is a significant process in the invasion and metastasis of cancers including oral squamous cell carcinoma (OSCC), and the cadherin switch has been identified as one of the hallmarks of EMT. The aim of the present study was to evaluate the significance of the cadherin switch in the prognosis of OSCC and generate a model for prognostic predictions. Seventy-six
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Correlation of Circulating CD64+/CD163+ Monocyte Ratio and stroma/peri-tumoral CD163+ Monocyte Density with Human Papillomavirus Infected Cervical Lesion Severity. Cancer Microenviron. Pub Date : 2017-10-24 Piyawut Swangphon,Chamsai Pientong,Nuchsupha Sunthamala,Sureewan Bumrungthai,Miyuki Azuma,Pilaiwan Kleebkaow,Thumwadee Tangsiriwatthana,Ussanee Sangkomkamhang,Bunkerd Kongyingyoes,Tipaya Ekalaksananan
HPV infected cervical cells secrete mediators that are gradually changed and have influence on infiltrating M2 phenotypic monocytes in cervical lesions. However, profiles of circulating immune cells in women with cervical lesions and M2 phenotypic monocyte activity in HPV infected cervical lesions are limited. This study aimed to investigate circulating monocyte populations correlated with M2 phenotype
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Upregulation of Treg-Related Genes in Addition with IL6 Showed the Significant Role for the Distant Metastasis in Colorectal Cancer. Cancer Microenviron. Pub Date : 2017-09-03 L D Miteva,N S Stanilov,G М Cirovski,Spaska Angelova Stanilova
T helper 17 (Th17) and T regulatory (Treg) cytokines appear to be contributing greatly to colorectal cancer (CRC) development and progression. The aim of the current study was to investigate the expression of Foxp3; IL10; TGFB1; IL17A; IL6 and NOS2 genes in tumor tissue, regional positive lymph nodes and distant metastasis obtained from 26 patients with advanced CRC. Quantitative real-time polymerase
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Expression Profiling of the MAP Kinase Phosphatase Family Reveals a Role for DUSP1 in the Glioblastoma Stem Cell Niche. Cancer Microenviron. Pub Date : 2017-08-18 Bradley N Mills,George P Albert,Marc W Halterman
The dual specificity phosphatases (DUSPs) constitute a family of stress-induced enzymes that provide feedback inhibition on mitogen-activated protein kinases (MAPKs) critical in key aspects of oncogenic signaling. While described in other tumor types, the landscape of DUSP mRNA expression in glioblastoma (GB) remains largely unexplored. Interrogation of the REpository for Molecular BRAin Neoplasia
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Effects of Vacuolar H+-ATPase Inhibition on Activation of Cathepsin B and Cathepsin L Secreted from MDA-MB231 Breast Cancer Cells. Cancer Microenviron. Pub Date : 2017-08-02 Andrew Uhlman,Kelly Folkers,Jared Liston,Harshida Pancholi,Ayana Hinton
Studies indicate secreted cathepsins are involved in metastasis. V-ATPases, which are necessary for activating intracellular cathepsins, also play a role in metastasis and are targeted to the plasma membrane of metastatic breast cancer cells. We are interested in a connection between cell surface V-ATPases, activation of secreted cathepsins and the metastatic phenotype of MDA-MB231 cells. We investigated
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Human Metaplastic Breast Carcinoma and Decorin. Cancer Microenviron. Pub Date : 2017-06-26 Pia Boström,Annele Sainio,Natalja Eigėlienė,Anne Jokilammi,Klaus Elenius,Ilkka Koskivuo,Hannu Järveläinen
Metaplastic breast carcinoma (MBC) is a rare subtype of invasive breast cancer and has poor prognosis. In general, cancers are heterogeneous cellular masses comprised of different cell types and their extracellular matrix (ECM). However, little is known about the composition of the ECM and its constituents in MBC. Decorin is a ubiquitous ECM macromolecule known of its oncosuppressive activity. As such
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Participation of Tumor-Associated Myeloid Cells in Progression of Amelanotic Melanoma (RMM Tumor Line) in F344 Rats, with Particular Reference to MHC Class II- and CD163-Expressing Cells. Cancer Microenviron. Pub Date : 2017-06-16 A Bondoc,H M Golbar,M Pervin,C Katou-Ichikawa,M Tanaka,T Izawa,M Kuwamura,J Yamate
Tumor progression is often influenced by infiltration of myeloid cells; depending on the M1- or M2-like activation status, these cells may have either inhibitory or promoting effects on tumor growth. We investigated the properties of tumor-associated myeloid cells in a previously established homotransplantable amelanotic melanoma (RMM tumor line) in F344 rats. RMM tumor nodules were allowed to reach
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Epithelial Mesenchymal Transition (EMT) in Metastatic Breast Cancer in Omani Women. Cancer Microenviron. Pub Date : 2017-05-19 Ritu Lakhtakia,Adil Aljarrah,Muhammad Furrukh,Shyam S Ganguly
Breast cancer (BC) in Oman affects younger women and has a more aggressive course. Clinical and biological variables like age, pregnancy, tumor size, type, grade, receptor expression and proliferation predict disease aggression but there is no direct predictor of metastasis except lymphovascular invasion. Epithelial-mesenchymal transition (EMT) is characterized by epithelial cells losing epithelial
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The Impact of Microenvironment on the Synovial Sarcoma Transcriptome. Cancer Microenviron. Pub Date : 2017-04-13 Huifeng Jin,Jared J Barrott,Matthew G Cable,Michael J Monument,Daniel M Lerman,Kyllie Smith-Fry,Dakota Nollner,Kevin B Jones
Synovial sarcoma (SS) is initiated by a t(X;18) chromosomal translocation and resultant SS18-SSX fusion oncogene. Only a few SS cell lines exist. None has been compared to its source tumor. In order to compare matched tumor and cell line pairs, we performed RNAseq on 3 tumor/cell line pairs from a genetically engineered mouse model of SS, as well as 2 pairs from human SS tumors. Transcriptomes of mouse
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HFE Variants and the Expression of Iron-Related Proteins in Breast Cancer-Associated Lymphocytes and Macrophages. Cancer Microenviron. Pub Date : 2016-12-27 Oriana Marques,Ana Rosa,Luciana Leite,Paula Faustino,Alexandra Rêma,Berta Martins da Silva,Graça Porto,Carlos Lopes
The association of HFE (High Iron FE) major variants with breast cancer risk and behavior has been a matter of discussion for a long time. However, their impact on the expression of iron-related proteins in the breast cancer tissue has never been addressed. In the present study, hepcidin, ferroportin 1, transferrin receptor 1 (TfR1), and ferritin expressions, as well as tissue iron deposition were
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Density-Dependent Regulation of Glioma Cell Proliferation and Invasion Mediated by miR-9. Cancer Microenviron. Pub Date : 2016-12-14 Mark Katakowski,Nicholas Charteris,Michael Chopp,Evgeniy Khain
The phenotypic axis of invasion and proliferation in malignant glioma cells is a well-documented phenomenon. Invasive glioma cells exhibit a decreased proliferation rate and a resistance to apoptosis, and invasive tumor cells dispersed in brain subsequently revert to proliferation and contribute to secondary tumor formation. One miRNA can affect dozens of mRNAs, and some miRNAs are potent oncogenes
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Neuropeptide Levels as well as Neprilysin Activity Decrease in Renal Cell Carcinoma. Cancer Microenviron. Pub Date : 2016-10-19 Nuray Erin,Tümay İpekçi,Bahar Akkaya,İrem Hicran Özbudak,Mehmet Baykara
Calcitonin Gene-related Peptide (CGRP), Vasoactive Intestinal Peptide (VIP) and Substance P (SP) are sensory neuropeptides which may alter cancer growth through modulation of chronic inflammation. We recently reported that SP suppresses breast cancer growth and metastasis through neuroimmune modulation. These neuropeptides are hydrolyzed by Neprilysin (NEP) to bioactive fragments. Decreased activity
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Stiffened Extracellular Matrix and Signaling from Stromal Fibroblasts via Osteoprotegerin Regulate Tumor Cell Invasion in a 3-D Tumor in Situ Model. Cancer Microenviron. Pub Date : 2016-09-21 Joshua S McLane,Lee A Ligon
Several changes have been described in the stroma surrounding a tumor, including changes in cellular composition, altered extracellular matrix composition and organization, and increases in stiffness. Tumor cells are influenced by the composition, organization, and mechanical properties of the microenvironment, and by signals from stromal cells. Here we sought to test whether signaling from stromal
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Investigating Effects of Acidic pH on Proliferation, Invasion and Drug-Induced Apoptosis in Lymphoblastic Leukemia. Cancer Microenviron. Pub Date : 2016-07-25 Mahbobeh Bohloli,Amir Atashi,Masoud Soleimani,Saeid Kaviani,Azadeh Anbarlou
Some studies have shown that extracellular pH in tumors, which results in tumor progression, is less than that in normal tissues. The aim of this study was to investigate the effects of extracellular acidic pH on proliferation, invasion, and drug-induced apoptosis in acute lymphoblastic cells. The cells were cultured in different pH (pH 6.6 and pH 7.4) for 12 days. Cell proliferation was assessed by
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Biopathological Significance of TLR9 Expression in Cancer Cells and Tumor Microenvironment Across Invasive Breast Carcinomas Subtypes. Cancer Microenviron. Pub Date : 2016-07-09 Didier Meseure,Sophie Vacher,Kinan Drak Alsibai,Martine Trassard,André Nicolas,Renaud Leclere,Florence Lerebours,Jean Marc Guinebretiere,Elisabetta Marangoni,Rosette Lidereau,Ivan Bieche
Toll-like receptors (TLRs) are pattern recognition receptors mainly expressed by cells of the immune system but also by epithelial tumor cells. Little is known about expression patterns of TLR genes in breast tumors, and their clinical significance is unclear. The aim of our study was to investigate expression of TLRs pathway components in pre-invasive breast lesions and invasive breast carcinomas
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Active Secretion of Dimerized S100A11 Induced by the Peroxisome in Mesothelioma Cells. Cancer Microenviron. Pub Date : 2016-06-22 Satomi Saho,Hiroki Satoh,Eisaku Kondo,Yusuke Inoue,Akira Yamauchi,Hitoshi Murata,Rie Kinoshita,Ken-Ichi Yamamoto,Junichiro Futami,Endy Widya Putranto,I Made Winarsa Ruma,I Wayan Sumardika,Chen Youyi,Ken Suzawa,Hiromasa Yamamoto,Junichi Soh,Shuta Tomida,Yoshihiko Sakaguchi,Ken Saito,Hidekazu Iioka,Nam-Ho Huh,Shinichi Toyooka,Masakiyo Sakaguchi
S100A11, a small Ca2+ binding protein, acts extracellularly as a mediator of cancer progression. That raises the question of how a protein that lacks the classical secretory signal is able to be secreted outside cells without being damaged. Some insights into this question have been obtained, and there has been accumulating evidence indicating a pivotal role of a non-classical vesicle-mediated pathway
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Potential Role of TRAIL in Metastasis of Mutant KRAS Expressing Lung Adenocarcinoma. Cancer Microenviron. Pub Date : 2016-04-23 Shyama Pal,Prayag J Amin,K B Sainis,Bhavani S Shankar
Apo2L/tumor necrosis factor (TNF)-α-related apoptosis-inducing ligand (TRAIL, TNFSF10) is an important cytokine in the tumor microenvironment and plays a major role in the balance of cell survival/death pathways. Bioinformatic analyses of 839 adenocarcinoma (AC) and 356 squamous cell lung carcinoma patient data (SCC) by cBioPortal (genomic analyses) shows that TRAIL expression leads to differential
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Review: the Contribution of both Nature and Nurture to Carcinogenesis and Progression in Solid Tumours. Cancer Microenviron. Pub Date : 2016-04-11 Iain Joseph Hyndman
Cancer is a leading cause of mortality worldwide. Cancer arises due to a series of somatic mutations that accumulate within the nucleus of a cell which enable the cell to proliferate in an unregulated manner. These mutations arise as a result of both endogenous and exogenous factors. Genes that are commonly mutated in cancer cells are involved in cell cycle regulation, growth and proliferation. It
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Influence of Immune Myeloid Cells on the Extracellular Matrix During Cancer Metastasis. Cancer Microenviron. Pub Date : 2016-03-09 David Jiang,Su Yin Lim
The extracellular matrix (ECM) is one of the most important components within the tumor microenvironment that supports cancer development and metastasis. Under normal physiological conditions, the ECM is a tightly regulated network providing structural and biochemical support. However, the ECM becomes highly disorganized during neoplastic progression and consequently, stimulates cancer cell transformation
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Stomach Cancer: Interconnection between the Redox State, Activity of MMP-2, MMP-9 and Stage of Tumor Growth. Cancer Microenviron. Pub Date : 2016-02-23 Anatoly P Burlaka,Irina I Ganusevich,Marat R Gafurov,Sergey M Lukin,Evgeny P Sidorik
High levels of reactive oxygen (ROS) and nitrogen (RNS) species can lead to the destruction of extracellular matrix facilitating tumor progression. ROS can activate matrix metalloproteinases (MMP), damage DNA and RNA. Therefore, the levels of MMP, ROS and RNS can serve as additional prognostic markers and for the estimation of the effectiveness of tumor therapy. Concerning gastric cancer, the prognostic
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Angiopoietins Modulate Survival, Migration, and the Components of the Ang-Tie2 Pathway of Chronic Lymphocytic Leukaemia (CLL) Cells In Vitro. Cancer Microenviron. Pub Date : 2016-02-05 Luis Mario Aguirre Palma,Hanna Flamme,Iris Gerke,Karl-Anton Kreuzer
In actuality, chronic lymphocytic leukaemia (CLL) remains an incurable haematopoietic malignancy of high prevalence amongst elderly populations in the West. Malignant CLL cells characteristically accumulate in the peripheral blood, bone marrow, lymph nodes, and spleen of CLL patients. There is evidence that CLL cells express Ang2 and Tie1, two central components of the Ang-Tie2 pro-angiogenic pathway