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Hsa_circ_0101050 accelerates the progression of Colon cancer by targeting the miR-140–3 p/MELK axis Transl. Oncol. (IF 5.0) Pub Date : 2024-04-04 Kuoju Cheng, Hao Chen, Bin Chen, Jing Li, Caibo Fan, Huan Yan, Wei Huang, Ting Zhao, Yun Luo, Lei Peng
Circular RNAs (circRNAs) are involved in the progression of colon cancer (CC). This study aimed to examine the role of a new circRNA circ_0101050 in CC. Dual-luciferase reporter and RNA immunoprecipitation analyses were performed to validate the target relationships among maternal embryonic leucine zipper kinase (MELK), microRNA (miR)-140–3 p, and circ_0101050. Expression levels were calculated using
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miRNA patterns in male LUSC patients - the 3-way mirror: Tissue, plasma and exosomes Transl. Oncol. (IF 5.0) Pub Date : 2024-04-01 Cecilia Bica, Ancuta Jurj, Antonia Harangus, Cristina Ciocan, Alin Moldovan, Oana Zanoaga, Claudia Burz, Manuela Ferracin, Lajos Raduly, Ioana Berindan-Neagoe
Lung cancer remains one of the leading causes of cancer-related deaths worldwide. It is classified into two main histological groups: non-small cell lung cancer (NSCLC) and small cell lung cancer. Improving the outcome of cancer patients could be possible by enhancing the early diagnosis. In the current study, we evaluated the levels of three microRNAs - miR-21-5p, miR-155-5p, and miR-181a-5p in tumor
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Expression of KCNN4 in adult-type diffuse gliomas and its correlations with clinicopathological features and patient prognosis Transl. Oncol. (IF 5.0) Pub Date : 2024-03-30 Jun Yang, Zhuonan Pu, Xiaorong Tao, Jiajia Liu, Ke Li, Jiawei Shi, Hui Qiao, Xing Fan
The KCa3.1 channel (KCNN4) is extensively investigated as an oncogene in human cancers. The current study aimed to explore the clinicopathological significance of KCNN4 expression in patients with primary adult-type diffuse gliomas. Demographic, RNA-seq, and follow-up data of 477 patients were retrospectively reviewed. Patients were divided into the experimental and validation groups (278 and 199)
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Metformin as anticancer agent and adjuvant in cancer combination therapy: Current progress and future prospect Transl. Oncol. (IF 5.0) Pub Date : 2024-03-30 Lin Zhu, Kaiqing Yang, Zhe Ren, Detao Yin, Yubing Zhou
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Identification of a cisplatin resistant-based prognostic immune related gene signature in MIBC Transl. Oncol. (IF 5.0) Pub Date : 2024-03-30 Yunfei Wu, Zhijie Xu, Guanghou Fu, Xiaoyi Chen, Junjie Tian, Hairong Cai, Peng Jiang, Baiye Jin
Cisplatin resistance plays a significant role in the dismal prognosis and progression of muscle-invasive bladder cancer (MIBC). However, the strategies to predict prognosis and cisplatin resistance are inefficient, and it remains unclear whether cisplatin resistance is associated with tumor immunity. In this study, we integrated the transcriptional data from cisplatin-resistant cell lines and a TCGA-MIBC
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An advanced nomogram model using deep learning radiomics and clinical data for predicting occult lymph node metastasis in lung adenocarcinoma Transl. Oncol. (IF 5.0) Pub Date : 2024-03-29 Guanchao Ye, Chi Zhang, Yuzhou Zhuang, Hong Liu, Enmin Song, Kuo Li, Yongde Liao
To evaluate the effectiveness of deep learning radiomics nomogram in distinguishing the occult lymph node metastasis (OLNM) status in clinical stage IA lung adenocarcinoma. A cohort of 473 cases of lung adenocarcinomas from two hospitals was included, with 404 cases allocated to the training cohort and 69 cases to the testing cohort. Clinical characteristics and semantic features were collected, and
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High-dimensional deconstruction of ovarian cancer at single-cell precision reveals HEBP2 that reshape the TIME and drive carboplatin resistance Transl. Oncol. (IF 5.0) Pub Date : 2024-03-29 BiKang Yang, Miao Dai
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Machine learning analysis reveals tumor stiffness and hypoperfusion as biomarkers predictive of cancer treatment efficacy Transl. Oncol. (IF 5.0) Pub Date : 2024-03-28 Demetris Englezos, Chrysovalantis Voutouri, Triantafyllos Stylianopoulos
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Low NT5DC2 expression predicts favorable prognosis and suppresses soft tissue sarcoma progression via ECM-receptor interaction pathway Transl. Oncol. (IF 5.0) Pub Date : 2024-03-27 Zhen Huang, Enjie Xu, Xiaolong Ma, Yongjie Wang, Jiazhuang Zhu, Kunpeng Zhu, Jianping Hu, Chunlin Zhang
Soft tissue sarcoma, a malignant tumor arising from mesenchymal tissues with poor prognosis. 5′-Nucleotidase Domain Containing 2 (NT5DC2) is a novel oncogene, and the precise involvement of NT5DC2 in soft tissue sarcoma were still undefined. Hence, our study aims to investigate NT5DC2 functions in soft tissue sarcoma progression. The tumor immune single-cell hub 2 (TISCH2) website, The Cancer Genome
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A regionally based precision medicine implementation initiative in North Africa:The PerMediNA consortium Transl. Oncol. (IF 5.0) Pub Date : 2024-03-26 Yosr Hamdi, Maroua Boujemaa, Jihenne Ben Aissa-Haj, Fouzia Radouani, Meriem Khyatti, Najah Mighri, Mariem Hannachi, Kais Ghedira, Oussema Souiai, Chaima Hkimi, Mohamed Selim Kammoun, Nesrine Mejri, Hanen Bouaziz, Mohamed Amine Beloufa, Hicham Charoute, Abdelhamid Barakat, Imène Najjar, Hiroaki Taniguchi, Natalia Pietrosemoli, PerMediNA Consortium, Abdellatif benider, Adil El-hamouchi, AIT YOUNES Sonia
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Assessment of targeted therapy opportunities in sinonasal cancers using patient-derived functional tumor models Transl. Oncol. (IF 5.0) Pub Date : 2024-03-23 Noora Lehtinen, Janne Suhonen, Kiesha Rice, Eetu Välimäki, Mervi Toriseva, Johannes Routila, Perttu Halme, Melissa Rahi, Heikki Irjala, Ilmo Leivo, Markku Kallajoki, Matthias Nees, Teijo Kuopio, Sami Ventelä, Juha K. Rantala
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Development of a novel prostate Cancer-Stroma Sphere (CSS) model for In Vitro tumor microenvironment studies Transl. Oncol. (IF 5.0) Pub Date : 2024-03-22 Aigul R. Rakhmatullina, Maria A. Zolotykh, Yulia V. Filina, Rimma N. Mingaleeva, Aisylu R. Sagdeeva, Eugenia A. Boulygina, Dina U. Gafurbaeva, Emil R. Bulatov, Albert A. Rizvanov, Regina R. Miftakhova
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NUF2 regulated the progression of hepatocellular carcinoma through modulating the PI3K/AKT pathway via stabilizing ERBB3 Transl. Oncol. (IF 5.0) Pub Date : 2024-03-20 Yiwei Liu, Yuming Wang, Jifei Wang, Wangjie Jiang, Yananlan Chen, Jijun Shan, Xiao Li, Xiaofeng Wu
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FEN1 upregulation mediated by SUMO2 via antagonizing proteasomal degradation promotes hepatocellular carcinoma stemness Transl. Oncol. (IF 5.0) Pub Date : 2024-03-20 Zhenxiang Peng, Shuling Wang, Diguang Wen, Zhechuan Mei, Hao Zhang, Shengtao Liao, Lin Lv, Chuanfei Li
Metastasis of hepatocellular carcinoma (HCC) critically impacts the survival prognosis of patients, with the pivotal role of hepatocellular carcinoma stem cells in initiating invasive metastatic behaviors. The Flap Endonuclease 1 (FEN1) is delineated as a metallonuclease, quintessential for myriad cellular processes including DNA replication, DNA synthesis, DNA damage rectification, Okazaki fragment
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Specific vaginal and gut microbiome and the anti-tumor effect of butyrate in cervical cancer women Transl. Oncol. (IF 5.0) Pub Date : 2024-03-19 Mengzhen Han, Na Wang, Wenjie Han, Xiaolin Liu, Tao Sun, Junnan Xu
To investigate the vaginal and gut microbes changes during the carcinogenesis of cervical and the auxiliary diagnostic value. To investigate the effect of microbiome-specific metabolites butyric on cervical cancer cells. We studied 416 vaginal 16S rRNA sequencing data and 116 gut sequencing data. Reads were processed using VSEARCH. We used Shannon index, Chao1 index, Simpson diversity index, β diversity
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Predictive value of peripheral blood leukocytes-based methylation of Long non-coding RNA MALAT1 and H19 in the chemotherapy effect and prognosis of gastric cancer Transl. Oncol. (IF 5.0) Pub Date : 2024-03-16 Fang Wang, Dingtao Hu, Xiaoqi Lou, Linlin Wang, Yuhua Wang, Tingyu Zhang, Ziye Yan, Nana Meng, Yu Lei, Yanfeng Zou
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Exploring the role of disulfidptosis-related signatures in immune microenvironment, prognosis and therapeutic strategies of cervical cancer Transl. Oncol. (IF 5.0) Pub Date : 2024-03-15 Tianzhe Jin, Taotao Yin, Ruiyi Xu, Hong Liu, Shuo Yuan, Yite Xue, Jianwei Zhang, Hui Wang
Cervical cancer is characterized by a complex immunosuppressive tumor microenvironment (TME). Disulfidptosis is a recently identified form of programmed cell death that has emerged as a crucial factor in tumorigenesis. However, the research on the specific involvement of disulfidptosis within the TME is still in its early stages. Under glucose starvation, SiHa and HeLa cells underwent experiments employing
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Insights into the role of the N6-methyladenosine reader IGF2BP3 in the progression of oral squamous cell carcinoma and its connection to cell-cycle control Transl. Oncol. (IF 5.0) Pub Date : 2024-03-15 Dandan Song, Xiaofeng Dai, Minna Fu, Yang Sun, Xingwen Wu, Qianrong Zhou, Wei Bi, Jian Sun, Fei Yang, Youcheng Yu
The genome of oral squamous cell carcinoma (OSCC) has been extensively characterized via bulk sequencing, revealing a multitude of genetic changes. The gene IGF2BP3, which encodes for the insulin-like growth factor 2 mRNA-binding protein 3, has been observed to be highly expressed in several types of cancer. This finding suggests that IGF2BP3 may play a significant role in the initiation and advancement
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Efficacy and delivery strategies of the dual Rac/Cdc42 inhibitor MBQ-167 in HER2 overexpressing breast cancer Transl. Oncol. (IF 5.0) Pub Date : 2024-03-15 Luis E. Velázquez-Vega, Michael Rivera-Robles, Annelis O. Sánchez-Álvarez, Pablo E. Vivas-Mejía, Miciely Aponte-Reyes, Ailed M. Cruz-Collazo, Nilmary Grafals-Ruiz, Stephanie Dorta-Estremera, Eliud Hernández-O'Farrill, Cornelis P Vlaar, Suranganie Dharmawardhane
Trastuzumab and trastuzumab-based treatments are the standard of care for breast cancer patients who overexpress the human epidermal growth factor receptor 2 (HER2). However, patients often develop resistance to trastuzumab via signaling from alternative growth factor receptors that converge to activate guanine nucleotide exchange factors (GEFs) that in turn activate the Rho GTPases Rac and Cdc42.
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Ovarian cancer ascites confers platinum chemoresistance to ovarian cancer cells Transl. Oncol. (IF 5.0) Pub Date : 2024-03-14 Yifat Koren Carmi, Abed Agbarya, Hazem Khamaisi, Raymond Farah, Yelena Shechtman, Roman Korobochka, Jacob Gopas, Jamal Mahajna
Ovarian cancer (OC), the second most common form of gynecologic malignancy, has a poor prognosis and is often discovered in the late stages. Platinum-based chemotherapy is the first line of therapy. Nevertheless, treatment OC has proven challenging due to toxicity and the development of acquired resistance to therapy. Tumor microenvironment (TME) has been associated with platinum chemoresistance.
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Single-cell sequencing revealed metabolic reprogramming and its transcription factor regulatory network in prostate cancer Transl. Oncol. (IF 5.0) Pub Date : 2024-03-06 Guojiang Wei, Hongcai Zhu, Yupeng Zhou, Yang Pan, Bocun Yi, Yangkai Bai
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CCR7 affects the tumor microenvironment by regulating the activation of naïve CD8+ T cells to promote the proliferation of oral squamous cell carcinoma Transl. Oncol. (IF 5.0) Pub Date : 2024-03-02 Cong Yan, Weidong Du, Keith L. Kirkwood, Yao Wang, Wanhang Zhou, Zhenning Li, Yuan Tian, Shanfeng Lin, Li Zheng, Maged Ali Al-Aroomi, Jiaxing Gao, Sheng Jiang, Changfu Sun, Fayu Liu
Head and neck cancer is the sixth most common malignancy worldwide, and oral squamous cell carcinoma (OSCC) is the most common head and neck cancer, being one of the leading causes of cancer morbidity and mortality worldwide. CC Chemokine receptor 7(CCR7) is a multifunctional G protein-coupled trans-membrane chemokine that affects immune cell chemotaxis, migration, and cancer progression through its
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Genomic profiles and their relationships with clinical characteristics and immune features in cervical cancer Transl. Oncol. (IF 5.0) Pub Date : 2024-03-02 Zinan Lu, Peiwen Fan, Wen Huo, Yaning Feng, Ruozheng Wang
This study aimed to investigate the genomic alteration profiles of cervical cancer patients, examine the correlation between mutation patterns and clinical and immune attributes, and discover novel targets for treatment of individuals with cervical cancer. We performed targeted next-generation sequencing of tumor tissues and blood samples obtained from 45 cervical cancer patients to analyze somatic
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Cell-free DNA in plasma and ascites as a biomarker of bevacizumab response- a translational research sub-study of the REZOLVE (ANZGOG-1101) clinical trial Transl. Oncol. (IF 5.0) Pub Date : 2024-02-27 Bonnita Werner, Katrin M Sjoquist, David Espinoza, Sonia Yip, Garry Chang, Michelle M Cummins, Linda Mileshkin, Sumitra Ananda, Catherine Shannon, Michael Friedlander, Kristina Warton, Caroline E. Ford
To investigate cell-free DNA (cfDNA) in plasma and ascites and its association with clinical outcomes (paracentesis-free interval, overall survival) and CA125 level in participants with advanced ovarian cancer, treated with palliative intraperitoneal bevacizumab to delay re-accumulation of ascites. cfDNA was extracted from 0.3 to 1 mL samples from 20/24 participants of the REZOLVE trial. Standard and
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The highly selective and oral phosphoinositide 3-kinase delta (PI3K-δ) inhibitor roginolisib induces apoptosis in mesothelioma cells and increases immune effector cell composition Transl. Oncol. (IF 5.0) Pub Date : 2024-02-27 Claudia Kalla, German Ott, Francesca Finotello, Karolina Niewola-Staszkowska, Giusy Di Conza, Michael Lahn, Lars van der Veen, Julia Schüler, Roger Falkenstern-Ge, Joanna Kopecka, Chiara Riganti
Targeting aberrantly expressed kinases in malignant pleural mesothelioma (MPM) is a promising therapeutic strategy. We here investigated the effect of the novel and highly selective Phosphoinositide 3-kinase delta (PI3K-δ) inhibitor roginolisib (IOA-244) on MPM cells and on the immune cells in MPM microenvironment.
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Prediction of immunotherapy responsiveness in melanoma through single-cell sequencing-based characterization of the tumor immune microenvironment Transl. Oncol. (IF 5.0) Pub Date : 2024-02-27 Yucheng Dong, Zhizhuo Chen, Fan Yang, Jiaxin Wei, Jiuzuo Huang, Xiao Long
Immune checkpoint inhibitors (ICB) therapy have emerged as effective treatments for melanomas. However, the response of melanoma patients to ICB has been highly heterogenous. Here, by analyzing integrated scRNA-seq datasets from melanoma patients, we revealed significant differences in the TiME composition between ICB-resistant and responsive tissues, with resistant or responsive tissues characterized
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XIAP overexpressing inflammatory breast cancer patients have high infiltration of immunosuppressive subsets and increased TNFR1 signaling targetable with Birinapant Transl. Oncol. (IF 5.0) Pub Date : 2024-02-27 Christophe Van Berckelaer, Steven Van Laere, Seayoung Lee, Michael A Morse, Joseph Geradts, Luc Dirix, Mark Kockx, François Bertucci, Peter Van Dam, Gayathri R Devi
To assess the expression pattern of X-linked inhibitor of apoptosis protein (XIAP), a cellular stress sensor, and delineate the associated changes in the tumor immune microenvironment (TiME) for prognostic value and new therapeutic targets in inflammatory breast cancer (IBC). Immunohistochemistry was conducted to assess the spatial localization of immune subsets, XIAP, and PDL1 expression in IBC and
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Loss of p53 epigenetically modulates epithelial to mesenchymal transition in colorectal cancer Transl. Oncol. (IF 5.0) Pub Date : 2024-02-27 Shreya Sharma, Harsha Rani, Yeshwanth Mahesh, Mohit Kumar Jolly, Jagannath Dixit, Vijayalakshmi Mahadevan
Wild type p53 binding sites are associated with promoters of SATB1 and with the loss of p53, these promoters are occupied by repressive histone marks H3K27me3 correlating with decreased expression of SATB1 (unpublished work from the lab). Expression of SATB1 antagonistically relates with EZH2 which correlates with our findings. Upon EMT induction with TGF-β treatment, the expression of SATB1 increases
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Preclinical evaluation of engineered L-asparaginase variants to improve the treatment of Acute Lymphoblastic Leukemia Transl. Oncol. (IF 5.0) Pub Date : 2024-02-26 Soumika Sengupta, Mainak Biswas, Khushboo A. Gandhi, Saurabh Kumar Gupta, Poonam B. Gera, Vikram Gota, Avinash Sonawane
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Comprehensive analysis and experimental verification of the mechanism of action of T cell-mediated tumor-killing related genes in Colon adenocarcinoma Transl. Oncol. (IF 5.0) Pub Date : 2024-02-26 Jing Chen, Zhengfang Wang, Qin Zhu, Shiqi Ren, Yanhua Xu, Guangzhou Wang, Lin Zhou
Colorectal cancer (CRC) is a prevalent malignancy of the digestive tract. A new prognostic scoring model for colon adenocarcinoma (COAD) is developed in this study based on the genes involved in tumor cell-mediated killing of T cells (GSTTKs), accurately stratifying COAD patients, thus improving the current status of personalized treatment. The GEO and TCGA databases served as the sources of the data
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Comprehensive genomic and clinical analyses identify APOBEC mutational signatures as a brain metastasis risk factor in lung adenocarcinoma patients Transl. Oncol. (IF 5.0) Pub Date : 2024-02-24 Qiang Li, Meng Jiang, Shiqiang Hong, Jing Yang, Xiaoying Wu, Jiaohui Pang, Yedan Chen, Xiaotian Zhao, Xiao Ding
Lung adenocarcinoma is the most common source of brain metastasis (BM), resulting in significant morbidity and mortality. We aimed to identify patients with high BM risk who possibly benefit from brain-penetrant drugs, prophylactic cranial irradiation, or close brain magnetic resonance imaging surveillance. Metastatic lung adenocarcinoma patients with extracranial tumor samples profiled by a next-generation
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CT-guided high dose rate brachytherapy can induce multiple systemic proteins of proliferation and angiogenesis predicting outcome in HCC Transl. Oncol. (IF 5.0) Pub Date : 2024-02-23 Lukas Salvermoser, Shraga Nahum Goldberg, Marianna Alunni-Fabbroni, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Jan Niklas Schäfer, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Agnese Petrera, Moritz Wildgruber, Jens Ricke, Matthias Stechele
To determine the potential prognostic value of proliferation and angiogenesis plasma proteins following CT-guided high dose rate brachytherapy (HDR-BT) of hepatocellular carcinoma (HCC). For this prospective study, HDR-BT (1 × 15 Gy) was administered to 24 HCC patients. Plasma was obtained and analyzed using an Olink proteomics Target-96 immuno-oncology-panel that included multiple markers of angiogenesis
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Apigenin enhances sorafenib anti-tumour efficacy in hepatocellular carcinoma Transl. Oncol. (IF 5.0) Pub Date : 2024-02-22 Deepti Singh, Mohammad Afsar Khan, Dhruv Mishra, Aditya Goel, Mairaj Ahmed Ansari, Kafil Akhtar, Hifzur R. Siddique
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Machine learning developed an intratumor heterogeneity signature for predicting prognosis and immunotherapy benefits in cholangiocarcinoma Transl. Oncol. (IF 5.0) Pub Date : 2024-02-22 Xu Chen, Bo Sun, Yu Chen, Yili Xiao, Yinghui Song, Sulai Liu, Chuang Peng
Cholangiocarcinoma is a kind of epithelial cell malignancy with high mortality. Intratumor heterogeneity (ITH) is involved in tumor progression, aggressiveness, treatment resistance, and disease recurrence. Integrative machine learning procedure including 10 methods (random survival forest, elastic network, Lasso, Ridge, stepwise Cox, CoxBoost, partial least squares regression for Cox, supervised principal
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Genetic testing for hereditary cancer syndromes in Tunisian patients: Impact on health system Transl. Oncol. (IF 5.0) Pub Date : 2024-02-21 Nouha Jandoubi, Maroua Boujemaa, Najah Mighri, Nesrine Mejri, Sonia Ben Nasr, Hanen Bouaziz, Yosra Berrazega, Haifa Rachdi, Nouha Daoud, Aref Zribi, Jihene Ayari, Houda El Benna, Soumaya Labidi, Abderazzek Haddaoui, Ridha Mrad, Slim Ben Ahmed, Hamouda Boussen, Sonia Abdelhak, Samir Boubaker, Yosr Hamdi
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Multi-omics analysis-based macrophage differentiation-associated papillary thyroid cancer patient classifier Transl. Oncol. (IF 5.0) Pub Date : 2024-02-20 Hanlin Sun, Zhengyan Chang, Hongqiang Li, Yifeng Tang, Yihao Liu, Lixue Qiao, Guicheng Feng, Runzhi Huang, Dongyan Han, De-tao Yin
The reclassification of Papillary Thyroid Carcinoma (PTC) is an area of research that warrants attention. The connection between thyroid cancer, inflammation, and immune responses necessitates considering the mechanisms of differential prognosis of thyroid tumors from an immunological perspective. Given the high adaptability of macrophages to environmental stimuli, focusing on the differentiation characteristics
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Polyene phosphatidylcholine enhances the therapeutic response of oxaliplatin in gastric cancer through Nrf2/HMOX1 mediated ferroptosis Transl. Oncol. (IF 5.0) Pub Date : 2024-02-19 Peijie Lei, Lianjing Cao, Hongjun Zhang, Jialei Fu, Xiaojuan Wei, Fei Zhou, Jingjing Cheng, Jie Ming, Haijun Lu, Tao Jiang
Oxaliplatin (OXA)-based chemotherapy is one of the first-line treatments for advanced gastric cancer. However, the potential risk for chemotherapy-induced hepatic injury can hinder its effectiveness. Polyene phosphatidylcholine (PPC) is often used as a hepatoprotective agent to counter OXA-induced hepatic injury; however, its impact on the antitumour effectiveness of OXA remains uncertain. Our retrospective
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Revealing underlying regulatory mechanisms of LINC00313 in Osimertinib-resistant LUAD cells by ceRNA network analysis Transl. Oncol. (IF 5.0) Pub Date : 2024-02-19 Dandan Ding, Chenguang Xu, Jufeng Zhang, Ying Zhang, Lipeng Xue, Jingjing Song, Zhiming Luo, Xiaoyu Hong, Jian Wang, Weicheng Liang, Xingyang Xue
Osimertinib, a third-generation epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), is the preferred treatment for EGFR-mutated lung cancer. However, acquired resistance inevitably develops. While non-coding RNAs have been implicated in lung cancer through various functions, the molecular mechanisms responsible for osimertinib resistance remain incompletely elucidated. RNA-sequencing
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Graphene therapy-related lncRNAs as prognostic and immune microenvironmental biomarkers in hepatocellular carcinoma Transl. Oncol. (IF 5.0) Pub Date : 2024-02-17 Weilong Ye, Hui Li, Juan Zhao, Deshuai Lu, Tao Tao, Xiao Zhu
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HNRNPL facilitates ferroptosis in hepatocellular carcinoma cells by promoting S100A9 expression Transl. Oncol. (IF 5.0) Pub Date : 2024-02-17 Lanfang Yang, Zhibo Zhang, Xiangqing Yao, Xukun Wu, Zhao Zhang
This study probed into the effect of HNRNPL on ferroptosis in hepatocellular carcinoma (HCC) cells and related molecular mechanisms. Expression patterns of HNRNPL, Recombinant S100 Calcium Binding Protein A9 (S100A9) were analyzed in HCC tissues or cells. Following transfection, HCC cell activity was analyzed, followed by detection of levels of ROS, iron content, LPO, MDA, and GSH as well as the expression
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Peptide-based inhibitors targeting the PD-1/PD-L1 axis: potential immunotherapeutics for cancer Transl. Oncol. (IF 5.0) Pub Date : 2024-02-14 Magdalena Bojko, Katarzyna Węgrzyn, Emilia Sikorska, Piotr Ciura, Claire Battin, Peter Steinberger, Katarzyna Magiera-Mularz, Grzegorz Dubin, Adam Kulesza, Adam K. Sieradzan, Marta Spodzieja, Sylwia Rodziewicz-Motowidło
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Tenascin-C as a potential biomarker and therapeutic target for esophageal squamous cell carcinoma Transl. Oncol. (IF 5.0) Pub Date : 2024-02-14 Yang Liu, Li-Yan Yang, Ding-Xiong Chen, Chen Chang, Qing Yuan, Yu Zhang, Yan Cai, Wen-Qiang Wei, Jia-Jie Hao, Ming-Rong Wang
To establish a prognostic model of esophageal squamous cell carcinoma (ESCC) patients based on tenascin-C (TNC) expression level and clinicopathological characteristics, and to explore the therapeutic potential of TNC inhibition. The expression of TNC was detected using immunohistochemistry (IHC) in 326 ESCC specimens and 50 normal esophageal tissues. Prognostic factors were determined by Cox regression
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Up-regulation of MIC19 promotes growth and metastasis of hepatocellular carcinoma by activating ROS/NF-κB signaling Transl. Oncol. (IF 5.0) Pub Date : 2024-02-13 Zhanbing Meng, Shixia Cheng, Weifang Wang, Zhouxia Wei, Zheng Guo, Xuying Zhao, Bing Wu, Hulin Chang, Nan Wang
Mitochondrial malfunction has been well-recognized as a critical step in the pathogenesis of many types of diseases, including cancer. MIC19 is a core a subunit of the MICOS complex that plays a critical role in maintaining the normal function of mitochondria. However, the biological functions of MIC19 in human hepatocellular carcinoma (HCC) remain unclear. The expression level of MIC19 in HCC was
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RNA-binding protein IGF2BP2 suppresses metastasis of clear cell renal cell carcinoma by enhancing CKB mRNA stability and expression Transl. Oncol. (IF 5.0) Pub Date : 2024-02-10 Junwu Ren, Bo Huang, Wei Li, Yongquan Wang, Xiaojuan Pan, Qiang Ma, Yuying Liu, Xiaolin Wang, Ce Liang, Yuying Zhang, Shimin Wang, Feifei Yang, Haiping Li, Hao Ning, Yan Jiang, Changhong Qin, Ai Ran, Bin Xiao
Clear cell renal cell carcinoma (ccRCC) is the most prevalent kidney cancer, with a highly aggressive phenotype and poor prognosis. RNA binding proteins (RBPs) play crucial roles in post-transcriptional gene regulation and have been implicated in tumorigenesis. RBPs have the potential to become a new therapeutic target for ccRCC. In this study, we screened and validated that insulin-like growth factor
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Insights into molecular mechanisms of chemotherapy resistance in cancer Transl. Oncol. (IF 5.0) Pub Date : 2024-02-10 Animesh Kar, Shivam Agarwal, Agrata Singh, Avinash Bajaj, Ujjaini Dasgupta
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Prognostic value of circulating short-length DNA fragments in unresected glioblastoma patients Transl. Oncol. (IF 5.0) Pub Date : 2024-02-09 Arthur Daban, Ludivine Beaussire-Trouvay, Émilie Lévêque, Cristina Alexandru, Isabelle Tennevet, Olivier Langlois, Ovidiu Veresezan, Florent Marguet, Florian Clatot, Frédéric Di Fiore, Nasrin Sarafan-Vasseur, Maxime Fontanilles
Liquid biopsy application is still challenging in glioblastoma patients and the usefulness of short-length DNA (slDNA) fragments is not established. The aim was to investigate slDNA concentration as a prognostic marker in unresected glioblastoma patients. Patients with unresected glioblastoma and treated by radiochemotherapy (RT/TMZ) were included. Plasmas were prospectively collected at three times:
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Mitochondria-related chemoradiotherapy resistance genes-based machine learning model associated with immune cell infiltration on the prognosis of esophageal cancer and its value in pan-cancer Transl. Oncol. (IF 5.0) Pub Date : 2024-02-06 Ziyu Liu, Zahra Zeinalzadeh, Tao Huang, Yingying Han, Lushan Peng, Dan Wang, Zongjiang Zhou, DIABATE Ousmane, Junpu Wang
Esophageal cancer, known for its high incidence and low five-year survival rate, poses significant treatment challenges. A key aspect of this challenge is the close link between mitochondria and resistance to chemoradiotherapy (CRT). Currently, there is a scarcity of biomarkers for predicting CRT response and prognosis in esophageal cancer. Our study addresses this gap by developing a prognostic model
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Development and validation of a deep learning signature for predicting lymphovascular invasion and survival outcomes in clinical stage IA lung adenocarcinoma: A multicenter retrospective cohort study Transl. Oncol. (IF 5.0) Pub Date : 2024-02-06 Kunfeng Liu, Xiaofeng Lin, Xiaojuan Chen, Biyun Chen, Sheng Li, Kunwei Li, Huai Chen, Li Li
The presence of lymphovascular invasion (LVI) influences the management and outcomes of patients with clinical stage IA lung adenocarcinoma. The objective was the development of a deep learning (DL) signature for the prediction of LVI and stratification of prognosis. A total of 2077 patients from three centers were retrospectively enrolled and divided into a training set ( = 1515), an internal validation
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Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture Transl. Oncol. (IF 5.0) Pub Date : 2024-02-05 Joseph Zenga, Musaddiq Awan, Anne Frei, Jamie Foeckler, Rachel Kuehn, Oscar Villareal Espinosa, Jennifer Bruening, Becky Massey, Stuart Wong, Aditya Shreenivas, Monica Shukla, Julia Kasprzak, Yunguang Sun, Md Shaheduzzaman, Fanghong Chen, Tyce Kearl, Heather A. Himburg
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ARID5A stabilizes Indoleamine 2,3-dioxygenase expression and enhances CAR T cell exhaustion in colorectal cancer Transl. Oncol. (IF 5.0) Pub Date : 2024-02-04 Dandan Wu, Guijun Wang, Shuang Wen, Xian Liu, Qiang He
Resistance to chimeric antigen receptor (CAR) T-cell therapy remains a significant challenge in the treatment of solid tumors. This resistance is attributed to various factors, including antigen loss, immunosuppressive tumor microenvironment, and upregulated checkpoint molecules. Indoleamine 2,3-dioxygenase 1 (IDO1) is an immunosuppressive enzyme that promotes immune escape in tumors. In this study
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Distinct leukocyte populations and cytokine secretion profiles define tumoral and peritumoral areas in renal cell carcinoma Transl. Oncol. (IF 5.0) Pub Date : 2024-02-03 Martina Borcinova, Robin Bartolini, Lily Koumbas Foley, Vojtech Novak, Pavla Taborska, Dmitry Stakheev, Michal Rataj, Daniel Smrz, Martina Fialova, Jaromir Hacek, Martin Komarc, Stepan Vesely, Marek Babjuk, Ilja Striz, Jirina Bartunkova, Tomas Buchler, Zuzana Ozaniak Strizova
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Transforming growth factor-β1 and soluble co-inhibitory immune checkpoints as putative drivers of immune suppression in patients with basal cell carcinoma Transl. Oncol. (IF 5.0) Pub Date : 2024-02-02 Mahlatse C.M. Kgokolo, Nonkululeko Z. Malinga, Helen C. Steel, Pieter W.A. Meyer, Teresa Smit, Ronald Anderson, Bernardo L. Rapoport
The current study compared the levels and possible associations between systemic soluble immune checkpoints (sICPs, = 17) and a group of humoral modulators of immune suppressor cells ( = 7) in a cohort of patients with basal cell carcinoma (BCC, = 40) and a group of healthy control subjects ( = 20).
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Corresponding ctDNA and tumor burden dynamics in metastatic melanoma patients on systemic treatment Transl. Oncol. (IF 5.0) Pub Date : 2024-02-02 Michael E. Egger, Evan Alexander, Tracy Van Meter, Maiying Kong, Aye Aye Maung, Roland Valdes, Melissa Barousse Hall, Mark W. Linder
Radiographic imaging is the current standard for monitoring progression of tumor-burden and therapeutic resistance in patients with metastatic melanoma. Plasma circulating tumor DNA (ctDNA) has shown promise as a survelience tool, but longitudinal data on the dynamics between plasma ctDNA concentrations and radiographic imaging is lacking. We evaluated the relationship between longitudinal radiographic
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A novel clinical nomogram for predicting cancer-specific survival in patients with non-serous epithelial ovarian cancer: A real-world analysis based on the Surveillance, Epidemiology, and End Results database and external validation in a tertiary center Transl. Oncol. (IF 5.0) Pub Date : 2024-02-02 Hui Zheng, Jingjing Chen, Jimiao Huang, Huan Yi, Shaoyu Zhang, Xiangqin Zheng
Currently, there is a lack of prognostic evaluation methods for non-serous epithelial ovarian cancer (EOC). We collected patients with non-serous EOC diagnosed between 2010 and 2017 from the Surveillance, Epidemiology, and End Results (SEER) database into a training cohort ( = 2078) and an internal validation cohort ( = 891). Meanwhile, patients meeting the criteria were screened from the Fujian Provincial
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PARVB promotes malignant melanoma progression and is enhanced by hypoxic conditions Transl. Oncol. (IF 5.0) Pub Date : 2024-02-01 Ting Wang, Zhiqiang Wu, Yifeng Bi, Yao Wang, Chenglong Zhao, Haitao Sun, Zhipeng Wu, Zhen Tan, Hao Zhang, Haifeng Wei, Wangjun Yan
Beta-Parvin (PARVB) is an actin-binding protein with functionality in extracellular matrix binding. Recent studies suggest its potential as a biomarker for various cancers, given its role in governing several malignancies. Yet, its involvement and modulatory mechanisms in malignant melanoma remain under-explored. In this research, we undertook a comprehensive pan-cancer analysis centered on PARVB.
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The role of tertiary lymphoid structure and B cells in nasopharyngeal carcinoma: Based on bioinformatics and experimental verification Transl. Oncol. (IF 5.0) Pub Date : 2024-01-31 Chujun Chen, Yan Zhang, Xiaoting Wu, Juan Shen
Transcriptomic characteristics and prognosis of tertiary lymphoid structures (TLS) and infiltrating B cells in nasopharyngeal carcinoma (NPC) remain unclear. Here, NPC transcriptomic data and clinical samples were used to investigate the role of infiltrating B cells and TLS in NPC. We investigated the gene expression and infiltrating immune cells of NPC patients and further investigated the clinical
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Small molecule agents for triple negative breast cancer: Current status and future prospects Transl. Oncol. (IF 5.0) Pub Date : 2024-01-29 Yan Ou, Mengchao Wang, Qian Xu, Binxu Sun, Yingjie Jia
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Identification of HSPD1 as a novel invasive biomarker associated with mitophagy in pituitary adenomas Transl. Oncol. (IF 5.0) Pub Date : 2024-01-29 Yu Zhang, Xin Ma, Congyu Liu, Zhixu Bie, Gemingtian Liu, Pinan Liu, Zhijun Yang
Background The crucial role of mitophagy in tumor progression has been recognized. Therefore, our study aimed to investigate the potential correlation between pituitary adenoma invasiveness and the mitophagy processes. Methods In this study, we used transcriptomics of postoperative tissue from 32 patients and quantitative proteomics of 19 patients to screen for mitophagy-related invasion genes in pituitary
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Clinical utility of Next Generation Sequencing of plasma cell-free DNA for the molecular profiling of patients with NSCLC at diagnosis and disease progression Transl. Oncol. (IF 5.0) Pub Date : 2024-01-29 Marzia Del Re, Giovanna Irene Luculli, Iacopo Petrini, Andrea Sbrana, Vieri Scotti, Diego de Miguel Perez, Lorenzo Livi, Stefania Crucitta, Mauro Iannopollo, Francesca Mazzoni, Martina Ruglioni, Carmelo Tibaldi, Emanuela Olmetto, Irene Stasi, Editta Baldini, Giacomo Allegrini, Lorenzo Antonuzzo, Franco Morelli, Andrea Pierini, Nicola Panzeri, Romano Danesi
Background The present study evaluates the utility of NGS analysis of circulating free DNA (cfDNA), which incorporates small amounts of tumor DNA (ctDNA), at diagnosis or at disease progression (PD) in NSCLC patients. Methods Comprehensive genomic profiling on cfDNA by NGS were performed in NSCLC patients at diagnosis (if tissue was unavailable/insufficient) or at PD to investigate potential druggable
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Pan-cancer analysis of ABCC1 as a potential prognostic and immunological biomarker Transl. Oncol. (IF 5.0) Pub Date : 2024-01-29 Tiantian Wang, Dean Rao, Chenan Fu, Yiming Luo, Junli Lu, Huifang Liang, Limin Xia, Wenjie Huang
ABCC1 belongs to the ATP-binding cassette (ABC) superfamily, which encompasses a total of 48 constituent members. ABCC1 has been shown to be associated with the growth, progression, and drug resistance of various types of cancer. However, the impact of ABCC1 on cancer immune infiltration and pan-cancer prognosis has been rarely studied. Our comprehensive pan-cancer analysis unveiled elevated ABCC1