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Autophagy in cancer immunotherapy: Perspective on immune evasion and cell death interactions Cancer Lett. (IF 9.7) Pub Date : 2024-04-05 Qiang Yu, Jiajun Ding, Shisen Li, Yunlong Li
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SOD1-high fibroblasts derived exosomal miR-3960 promotes cisplatin resistance in triple-negative breast cancer by suppressing BRSK2-mediated phosphorylation of PIMREG Cancer Lett. (IF 9.7) Pub Date : 2024-04-04 Kangdi Li, Han Lin, Anyi Liu, Cheng Qiu, Zejun Rao, Zhihong Wang, Siqi Chen, Xiaowei She, Shengyu Zhu, Pengcheng Li, Lang Liu, Qi Wu, Guihua Wang, Feng Xu, Shaotang Li
Platinum-based neoadjuvant therapy represented by cisplatin is widely employed in treating Triple-Negative Breast Cancer (TNBC), a particularly aggressive subtype of breast cancer. Nevertheless, the emergence of cisplatin resistance presents a formidable challenge to clinical chemotherapy efficacy. Herein, we revealed the critical role of tumor microenvironment (TME) derived exosomal miR-3960 and phosphorylation
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Colorectal cancer initiation: Understanding early-stage disease for intervention Cancer Lett. (IF 9.7) Pub Date : 2024-04-03 Chao Jiang, Qiujing Zhou, Ke Yi, Ying Yuan, Xin Xie
How tumors arise or the cause of precancerous lesions is a fundamental question in cancer biology. It is generally accepted that tumors originate from normal cells that undergo uncontrolled proliferation owing to genetic alterations. At the onset of adenoma formation, cancer driver mutations confer clonal growth advantage, enabling mutant cells to outcompete and eliminate the surrounding healthy cells
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CDK inhibition results in pharmacologic BRCAness increasing sensitivity to olaparib in BRCA1-WT and olaparib resistant in Triple Negative Breast Cancer Cancer Lett. (IF 9.7) Pub Date : 2024-04-03 Esin Orhan, Carolina Velazquez, Imene Tabet, Lise Fenou, Geneviève Rodier, Béatrice Orsetti, William Jacot, Claude Sardet, Charles Theillet
One in three Triple Negative Breast Cancer (TNBC) is Homologous Recombination Deficient (HRD) and susceptible to respond to PARP inhibitor (PARPi), however, resistance resulting from functional HR restoration is frequent. Thus, pharmacologic approaches that induce HRD are of interest. We investigated the effectiveness of CDK-inhibition to induce HRD and increase PARPi sensitivity of TNBC cell lines
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LncRNA RGMB-AS1 inhibits HMOX1 ubiquitination and NAA10 activation to induce ferroptosis in non-small cell lung cancer Cancer Lett. (IF 9.7) Pub Date : 2024-04-02 Gui-Bin Gao, Liang Chen, Jia-Feng Pan, Tao Lei, Xin Cai, Zhexue Hao, Qi Wang, Ge Shan, Jin Li
Ferroptosis, an iron-dependent regulated cell death caused by excessive lipid peroxide accumulation, has emerged as a promising therapeutic target in various cancers, including non-small cell lung cancer (NSCLC). In this study, we identified the long non-coding RNA RGMB-AS1 as a key regulator of ferroptosis in NSCLC. Mechanistically, RGMB-AS1 interacted with heme oxygenase 1 (HMOX1) and prevented its
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JAML promotes the antitumor role of tumor-resident CD8+ T cells by facilitating their innate-like function in human lung cancer Cancer Lett. (IF 9.7) Pub Date : 2024-04-01 Zhixing Hao, Zhongwei Xin, Yongyuan Chen, Zheyu Shao, Wei Lin, Wenxuan Wu, Mingjie Lin, Qinyuan Liu, Di Chen, Dang Wu, Pin Wu
Tissue-resident memory CD8+T cells (CD8+TRMs) are thought to play a crucial role in cancer immunosurveillance. However, the characteristics of CD8+TRMs in the tumor microenvironment (TME) of human non-small cell lung cancer (NSCLC) remain unclear. Here, we report that CD8+TRMs accumulate explicitly and exhibit a unique gene expression profile in the TME of NSCLC. Interestingly, these tumor-associated
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Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer Cancer Lett. (IF 9.7) Pub Date : 2024-03-30 Yi Zhou, Huali Li, Yaxin Zhang, Enen Zhao, Chengmei Huang, Xingyan Pan, Feng Shu, Zhihao Liu, Na Tang, Fengtian Li, Wenting Liao
Despite the approval of immune checkpoint blockade (ICB) therapy for various tumor types, its effectiveness is limited to only approximately 15% of patients with microsatellite instability-high (MSI-H) or mismatch repair deficiency (dMMR) colorectal cancer (CRC). Approximately 80%–85% of CRC patients have a microsatellite stability (MSS) phenotype, which features a rare T-cell infiltration. Thus, elucidating
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PGR-KITLG signaling drives a tumor-mast cell regulatory feedback to modulate apoptosis of breast cancer cells Cancer Lett. (IF 9.7) Pub Date : 2024-03-30 Zeyu Yang, Hongdan Chen, Supeng Yin, Hongbiao Mo, Fan Chai, Peng Luo, Yao Li, Le Ma, Ziying Yi, Yizeng Sun, Yan Chen, Jie Wu, Weihua Wang, Tingjie Yin, Junping Zhu, Chunmeng Shi, Fan Zhang
The immune microenvironment constructed by tumor-infiltrating immune cells and the molecular phenotype defined by hormone receptors (HRs) have been implicated as decisive factors in the regulation of breast cancer (BC) progression. Here, we found that the infiltration of mast cells (MCs) informed impaired prognoses in HR(+) BC but predicted improved prognoses in HR(−) BC. However, molecular features
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Is it time to discard the diagnostic and Statistical Manual of mental disorders (DSM) in psycho-oncology? Cancer Lett. (IF 9.7) Pub Date : 2024-03-28 Darren Haywood, Roman Kotov, Robert F. Krueger, Aidan G.C. Wright, Miriam K. Forbes, Evan Dauer, Frank D. Baughman, Susan L. Rossell, Nicolas H. Hart
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IL-1α facilitates GSH synthesis to counteract oxidative stress in oral squamous cell carcinoma under glucose-deprivation Cancer Lett. (IF 9.7) Pub Date : 2024-03-27 Yikang Ji, Zhen Zhang, Xinran Zhao, Zhiyin Li, Xin Hu, Mi Zhang, Xinhua Pan, Xu Wang, Wantao Chen
Understanding the intrinsic mechanisms underpinning cancer metabolism and therapeutic resistance is of central importance for effective nutrition-starvation therapies. Here, we report that () mRNA and IL-1α protein facilitate glutathione (GSH) synthesis to counteract oxidative stress and resistance against nutrition-starvation therapy in oral squamous cell carcinoma (OSCC). The expression of mRNA was
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Circular RNA circTATDN3 promotes the Warburg effect and proliferation in colorectal cancer Cancer Lett. (IF 9.7) Pub Date : 2024-03-27 Jiatong Lin, Wenhui Zhong, Zejian Lyu, Jingwen Peng, Yi Rong, Kejing Zeng, Jianguo Lai, Deqing Wu, Junjiang Wang, Yong Li, Jun Zheng, Jianwei Zhang, Zihao Pan
As one of the key metabolic enzymes in the glycolytic pathway, lactate dehydrogenase A (LDHA) might be linked to tumor proliferation by driving the Warburg effect. Circular RNAs (circRNAs) are widely implicated in tumor progression. Here, we report that circTATDN3, a circular RNA that interacts with LDHA, plays a critical role in proliferation and energy metabolism in CRC. We found that circTATDN3
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The emerging role of lactate in tumor microenvironment and its clinical relevance Cancer Lett. (IF 9.7) Pub Date : 2024-03-26 Sihan Chen, Yining Xu, Wei Zhuo, Lu Zhang
In recent years, the significant impact of lactate in the tumor microenvironment has been greatly documented. Acting not only as an energy substance in tumor metabolism, lactate is also an imperative signaling molecule. It plays key roles in metabolic remodeling, protein lactylation, immunosuppression, drug resistance, epigenetics and tumor metastasis, which has a tight relation with cancer patients’
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Activation of the FOXM1/ASF1B/PRDX3 axis confers hyperproliferative and antioxidative stress reactivity to gastric cancer Cancer Lett. (IF 9.7) Pub Date : 2024-03-26 Zhou Zhao, Zhaolun Cai, Su Zhang, Xiaonan Yin, Tianxiang Jiang, Chaoyong Shen, Yuan Yin, Hao Sun, Zhixin Chen, Junhong Han, Bo Zhang
Nucleosome assembly during DNA replication is dependent on histone chaperones. Recent studies suggest that dysregulated histone chaperones contribute to cancer progression, including gastric cancer (GC). Further studies are required to explore the prognostic and therapeutic implications of histone chaperones and their mechanisms of action in GC progression. Here we identified histone chaperone ASF1B
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USP40 promotes hepatocellular carcinoma progression through a YAP/USP40 positive feedback loop Cancer Lett. (IF 9.7) Pub Date : 2024-03-26 Huanye Mo, Runtian Li, Nan Yang, Jiaqi Han, Xuelian Xiao, Yilei Zhang, Zhengtao Xiao, Lianying Jiao, Qiuran Xu, Kangsheng Tu
Yes-associated protein (YAP) is an essential driver of hepatocellular carcinoma (HCC) progression and the ubiquitin-proteasome system controls its abundance. However, the role of ubiquitin-specific protease 40 (USP40) in YAP stability remains unclear. Here, USP40 was first identified as a novel regulator of YAP abundance and its target genes in HCC cells. USP40 interacted with YAP to remove the lysine
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OH2 oncolytic virus: A novel approach to glioblastoma intervention through direct targeting of tumor cells and augmentation of anti-tumor immune responses Cancer Lett. (IF 9.7) Pub Date : 2024-03-25 Yi Zheng, Xiaomin Wang, Qiang Ji, Aizhong Fang, Lairong Song, Xiaoying Xu, Yi Lin, Yichen Peng, Jianyu Yu, Lei Xie, Feng Chen, Xiaojie Li, Sipeng Zhu, Botao Zhang, Lili Zhou, Chunna Yu, YaLi Wang, Liang Wang, Han Hu, Ziyi Zhang, Binlei Liu, Zhen Wu, Wenbin Li
Glioblastoma (GBM), the deadliest central nervous system cancer, presents a poor prognosis and scant therapeutic options. Our research spotlights OH2, an oncolytic viral therapy derived from herpes simplex virus 2 (HSV-2), which demonstrates substantial antitumor activity and favorable tolerance in GBM. The extraordinary efficacy of OH2 emanates from its unique mechanisms: it selectively targets tumor
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Hexavalent chromium exposure activates the non-canonical nuclear factor kappa B pathway to promote immune checkpoint protein programmed death-ligand 1 expression and lung carcinogenesis Cancer Lett. (IF 9.7) Pub Date : 2024-03-23 Po-Shun Wang, Zulong Liu, Osama Sweef, Abdullah Farhan Saeed, Thomas Kluz, Max Costa, Kenneth R. Shroyer, Kazuya Kondo, Zhishan Wang, Chengfeng Yang
Lung cancer is the leading cause of cancer-related death worldwide; however, the mechanism of lung carcinogenesis has not been clearly defined. Chronic exposure to hexavalent chromium [Cr(VI)], a common environmental and occupational pollutant, causes lung cancer, representing an important lung cancer etiology factor. The mechanism of how chronic Cr(VI) exposure causes lung cancer remains largely unknown
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LncRNA GAS6-AS1 contributes to 5-fluorouracil resistance in colorectal cancer by facilitating the binding of PCBP1 with MCM3 Cancer Lett. (IF 9.7) Pub Date : 2024-03-22 Zhonglin Zhu, Minghan Li, Junyong Weng, Shanbao Li, Tianan Guo, Yang Guo, Ye Xu
5-Fluorouracil (5-FU) resistance has always been a formidable obstacle in the adjuvant treatment of advanced colorectal cancer (CRC). In recent years, long non-coding RNAs have emerged as key regulators in various pathophysiological processes including 5-FU resistance. TRG is a postoperative pathological score of the chemotherapy effectiveness for CRC, of which TRG 0–1 is classified as chemotherapy
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Pharmacological suppression of HHLA2 glycosylation restores anti-tumor immunity in colorectal cancer Cancer Lett. (IF 9.7) Pub Date : 2024-03-22 Dongze Zhang, Jinjing Xie, Fangxin Sun, Ruyan Xu, Wenjun Liu, Jia Xu, Xue Huang, Guangbo Zhang
Immunotherapy aimed at inhibiting the negative co-stimulatory molecule programmed cell death-ligand 1 (PD-L1) has limited effectiveness, with clinical response rates remaining below 10%–15%. Therefore, new immune checkpoints need to be explored. Our study focused on human endogenous retrovirus H long terminal repeat–associating protein 2 (HHLA2), a highly glycosylated member of the B7 family that is
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Targeting tumor-intrinsic SLC16A3 to enhance anti-PD-1 efficacy via tumor immune microenvironment reprogramming Cancer Lett. (IF 9.7) Pub Date : 2024-03-22 Ting Yu, Zhaoyun Liu, Qingxu Tao, Xin Xu, Xinyang Li, Yang Li, Minxin Chen, Rufei Liu, Dawei Chen, Meng Wu, Jinming Yu
Immunotherapy, especially immune checkpoint inhibitors, has revolutionized clinical practice within the last decade. However, primary and secondary resistance to immunotherapy is common in patients with diverse types of cancer. It is well-acknowledged that tumor cells can facilitate the formation of immunosuppressive microenvironments via metabolism reprogramming, and lactic acid, the metabolite of
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Microenvironmental changes in familial adenomatous polyposis during colorectal cancer carcinogenesis Cancer Lett. (IF 9.7) Pub Date : 2024-03-21 Kyoko Hisano, Yusuke Mizuuchi, Kenoki Ohuchida, Jun Kawata, Nobuhiro Torata, Jinghui Zhang, Naoki Katayama, Chikanori Tsutsumi, Shoichi Nakamura, Sho Okuda, Yoshiki Otsubo, Koji Tamura, Kinuko Nagayoshi, Naoki Ikenaga, Koji Shindo, Kohei Nakata, Yoshinao Oda, Masafumi Nakamura
Familial adenomatous polyposis (FAP) is a heritable disease that increases the risk of colorectal cancer (CRC) development because of heterozygous mutations in Little is known about the microenvironment of FAP. Here, single-cell RNA sequencing was performed on matched normal tissues, adenomas, and carcinomas from four patients with FAP. We analyzed the transcriptomes of 56,225 unsorted single cells
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Treatments on the horizon for locally advanced basal cell carcinoma Cancer Lett. (IF 9.7) Pub Date : 2024-03-21 Munir H. Idriss, Carolyn M. Stull, Michael R. Migden
Basal cell carcinoma (BCC) is one of the most common human cancers. Most cases of BCC are amenable to surgical and topical treatments with excellent prognosis if diagnosed timely and managed appropriately. However, in a small percentage of cases, it could be locally advanced BBC (laBCC) and not amenable to surgery or radiation, including recurrent, large tumors or tumors that invade deeper tissue.
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Disparities in mortality risk after diagnosis of hematological malignancies in 185 countries: A global data analysis Cancer Lett. (IF 9.7) Pub Date : 2024-03-19 Jing Yang, Xin Liu, Qiu-Zi Zhong, Yong Yang, Tao Wu, Si-Ye Chen, Bo Chen, Yong-Wen Song, Hui Fang, Shu-Lian Wang, Yue-Ping Liu, Jing Jin, Ning Li, Ning-Ning Lu, Hao Jing, Yuan Tang, Fan Chen, Xi-Mei Zhang, Wenwen Zhang, Yirui Zhai, Shu-Nan Qi, Ye-Xiong Li
This study was to report proxy measures for mortality risk in patients with hematological malignancies across 185 countries globally and explore its association with their socioeconomic status and treatment. The incidence, mortality, and 5-year prevalence data were extracted from the GLOBOCAN database. The data regarding the human development index (HDI), gross national income (GNI), vulnerability
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Candida albicans-myeloid cells-T lymphocytes axis in the tumor microenvironment of oral tumor-bearing mice Cancer Lett. (IF 9.7) Pub Date : 2024-03-17 Xu Wang, Tiansong Xu, Shuangshuang Wu, Linman Li, Xinjia Cai, Feng Chen, Zhimin Yan
() is associated with the development of oral cancer. Here, we report the altered tumor microenvironment in oral tumor-bearing mice caused by infection. Single-cell RNA sequencing showed that . infection influenced the tumor microenvironment significantly. Specifically, infection reduced the CD8 T cells but increased the IL-17A CD4 T cells and IL-17A γδ T cells in oral tumor. The neutralization of
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Patient-derived tumoroid models of pulmonary large-cell neuroendocrine carcinoma: a promising tool for personalized medicine and developing novel therapeutic strategies Cancer Lett. (IF 9.7) Pub Date : 2024-03-16 Etsuko Yokota, Miki Iwai, Takuro Yukawa, Yoshio Naomoto, Minoru Haisa, Yasumasa Monobe, Nagio Takigawa, Takuya Fukazawa, Tomoki Yamatsuji
Pulmonary large-cell neuroendocrine carcinoma (LCNEC), a disease with poor prognosis, is classified as pulmonary high-grade neuroendocrine carcinoma, along with small-cell lung cancer. However, given its infrequent occurrence, only a limited number of preclinical models have been established. Here, we established three LCNEC tumoroids for long-term culture. Whole-exome sequencing revealed that these
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An effective two-stage NMBzA-induced rat esophageal tumor model revealing that the FAT-Hippo-YAP1 axis drives the progression of ESCC Cancer Lett. (IF 9.7) Pub Date : 2024-03-16 Wei Zheng, Hui Yuan, Yuxia Fu, Guodong Deng, Xuejing Zheng, Lei Xu, Hongjun Fan, Wei Jiang, Xiying Yu
Rat model of N-nitrosomethylbenzylamine (NMBzA)-induced esophageal squamous cell carcinoma (ESCC) is routinely used to study ESCC initiation, progression and new therapeutic strategies. However, the model is time-consuming and malignant tumor incidences are low. Here, we report the usage of multi-kinase inhibitor sorafenib as a tumor promoter to establish an efficient two-stage NMBzA-induced rat ESCC
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Engineered bacteria in tumor immunotherapy Cancer Lett. (IF 9.7) Pub Date : 2024-03-15 Hua Chen, Yinrui Zhu, Chonghai Zhang, Lin Hu, Kai Yang
As the limitations of cancer immunotherapy become increasingly apparent, there is considerable anticipation regarding the utilization of biological tools to enhance treatment efficacy, particularly bacteria and their derivatives. Leveraging advances in genetic and synthetic biology technologies, engineered bacteria now play important roles far beyond those of conventional immunoregulatory agents, and
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Biodistribution and therapeutic efficacy of a gold nanoparticle-based targeted drug delivery system against pancreatic cancer Cancer Lett. (IF 9.7) Pub Date : 2024-03-15 Chandra Kumar Elechalawar, Suresh Kumar Gulla, Ram Vinod Roy, Nicolas Means, Yushan Zhang, Sima Asifa, David J. Robertson, Chao Xu, Resham Bhattacharya, Priyabrata Mukherjee
Pancreatic cancer is characterized by desmoplasia; crosstalk between pancreatic cancer cells (PCCs) and pancreatic stellate cells (PSCs) leads to the deposition of extracellular matrix proteins in the tumor environment resulting in poor vascularity. Targeting either PCCs or PSCs individually has produced mixed results, and there is currently no effective strategy to target both cell types simultaneously
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Systematic identification of a synthetic lethal interaction in brain-metastatic lung adenocarcinoma Cancer Lett. (IF 9.7) Pub Date : 2024-03-15 Jin Woo Moon, Beom-Jin Hong, Seon-Kyu Kim, Min-Seok Park, Hohyeon Lee, JiWon Lee, Mi-Young Kim
Metastatic lung adenocarcinoma (LuAC) presents a significant clinical challenge due to the short latency and the lack of efficient treatment options. Therefore, identification of molecular vulnerabilities in metastatic LuAC holds great importance in the development of therapeutic drugs against this disease. In this study, we performed a genome-wide siRNA screening using poorly and highly brain-metastatic
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Poly-pharmacology of existing drugs: How to crack the code? Cancer Lett. (IF 9.7) Pub Date : 2024-03-14 Baptiste Mouysset, Marion Le Grand, Luc Camoin, Eddy Pasquier
Drug development in oncology is highly challenging, with less than 5% success rate in clinical trials. This alarming figure points out the need to study in more details the multiple biological effects of drugs in specific contexts. Indeed, the comprehensive assessment of drug poly-pharmacology can provide insights into their therapeutic and adverse effects, to optimize their utilization and maximize
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Super-enhancer mediated upregulation of MYEOV suppresses ferroptosis in lung adenocarcinoma Cancer Lett. (IF 9.7) Pub Date : 2024-03-13 Shuimei Luo, Yang Luo, Ziming Wang, Haofeng Yin, Qing Wu, Xiaowei Du, Xianhe Xie
Super-enhancers (SEs) exerted a crucial role in regulating the transcription of oncogenes across various malignancies while the roles of SEs driven genes and the core regulatory elements remain elusive in LUAD. In this study, cancer-specific-SE-genes of lung adenocarcinoma (LUAD) were profiled through H3K27ac ChIP-seq data of cancer cell lines and normal lung tissues, which enriched in in biological
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EPIC-0628 abrogates HOTAIR/EZH2 interaction and enhances the temozolomide efficacy via promoting ATF3 expression and inhibiting DNA damage repair in glioblastoma Cancer Lett. (IF 9.7) Pub Date : 2024-03-13 Eryan Yang, Biao Hong, Yunfei Wang, Qixue Wang, Jixing Zhao, Xiaoteng Cui, Ye Wu, Shixue Yang, Dongyuan Su, Xiaomin Liu, Chunsheng Kang
The efficacy of temozolomide (TMZ) treatment in glioblastoma (GBM) is influenced by various mechanisms, mainly including the level of O-methylguanine-DNA methyltransferase (MGMT) and the activity of DNA damage repair (DDR) pathways. In our previous study, we had proved that long non-coding RNA HOTAIR regulated the GBM progression and mediated DDR by interacting with EZH2, the catalytic subunit of PRC2
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Chromatin activation with H3K36me2 and compartment shift in metastatic castration-resistant prostate cancer Cancer Lett. (IF 9.7) Pub Date : 2024-03-13 Sanji Kanaoka, Atsushi Okabe, Manato Kanesaka, Bahityar Rahmutulla, Masaki Fukuyo, Motoaki Seki, Takayuki Hoshii, Hiroaki Sato, Yusuke Imamura, Shinichi Sakamoto, Tomohiko Ichikawa, Atsushi Kaneda
Epigenetic modifiers are upregulated during the process of prostate cancer, acquiring resistance to castration therapy and becoming lethal metastatic castration-resistant prostate cancer (CRPC). However, the relationship between regulation of histone modifications and chromatin structure in CRPC has yet not fully been validated. Here, we reanalyzed publicly available clinical transcriptome and clinical
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Three-dimensional chromatin analysis reveals Sp1 as a mediator to program and reprogram HPV-host epigenetic architecture in cervical cancer Cancer Lett. (IF 9.7) Pub Date : 2024-03-11 Canhui Cao, Qian Xu, Zhixian Zhu, Miaochun Xu, Ye Wei, Shitong Lin, Sheng Cheng, Wenhua Zhi, Ping Hong, Xingyu Huang, Da Lin, Gang Cao, Yifan Meng, Ping Wu, Ting Peng, Juncheng Wei, Wencheng Ding, Xiaoyuan Huang, WingKin Sung, Gang Chen, Ding Ma, Guoliang Li, Peng Wu
Human papillomavirus (HPV) is predominantly associated with HPV-related cancers, however, the precise mechanisms underlying the HPV-host epigenetic architectures in HPV carcinogenesis remain elusive. Here, we employed high-throughput chromosome conformation capture (Hi-C) to comprehensively map HPV16/18-host chromatin interactions. Our study identified the transcription factor Sp1 as a pivotal mediator
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Lactate enhances NMNAT1 lactylation to sustain nuclear NAD+ salvage pathway and promote survival of pancreatic adenocarcinoma cells under glucose-deprived conditions Cancer Lett. (IF 9.7) Pub Date : 2024-03-11 Huimin Huang, Shitong Wang, Hongping Xia, Xingling Zhao, Kaiyuan Chen, Guihua Jin, Shipeng Zhou, Zhaoliang Lu, Tongke Chen, Huajun Yu, Xiaoqun Zheng, Haishan Huang, Linhua Lan
The aim of this study was to investigate the underlying molecular mechanism behind the promotion of cell survival under conditions of glucose deprivation by -lactate. To accomplish this, we performed tissue microarray and immunohistochemistry staining to analyze the correlation between the abundance of pan-Lysine lactylation and prognosis. evaluations of tumor growth were conducted using the KPC and
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Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma Cancer Lett. (IF 9.7) Pub Date : 2024-03-11 Honghao Zhang, Hao Wang, Yuxing Hu, Yang Gao, Jianyu Chen, Yabo Meng, Yingqi Qiu, Rong Hu, Peiyun Liao, Meifang Li, Yanjie He, Zhao Liang, Xiaoling Xie, Yuhua Li
Multiple myeloma (MM) is a hematological malignancy that remains incurable, primarily due to the high likelihood of relapse or development of resistance to current treatments. To explore and discover new medications capable of overcoming drug resistance in MM, we conducted cell viability inhibition screens of 1504 FDA-approved drugs. Lomitapide, a cholesterol-lowering agent, was found to exhibit effective
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Hypoxia-induced TREM1 promotes mesenchymal-like states of glioma stem cells via alternatively activating tumor-associated macrophages Cancer Lett. (IF 9.7) Pub Date : 2024-03-11 Minhai Dong, Xiaolin Zhang, Peng Peng, Zirong Chen, Yang Zhang, Lijun Wan, Wang Xiang, Guohao Liu, Yang Guo, Qungen Xiao, Baofeng Wang, Dongsheng Guo, Min Zhu, Xingjiang Yu, Feng Wan
The mesenchymal subtype of glioblastoma (GBM) cells characterized by aggressive invasion and therapeutic resistance is thought to be dependent on cell-intrinsic alteration and extrinsic cellular crosstalk. Tumor-associated macrophages (TAMs) are pivotal in tumor progression, chemo-resistance, angiogenesis, and stemness maintenance. However, the impact of TAMs on the shifts in glioma stem cells (GSCs)
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Characterization of the distinct immune microenvironments between hepatocellular carcinoma and intrahepatic cholangiocarcinoma Cancer Lett. (IF 9.7) Pub Date : 2024-03-11 Siao Jiang, Hao Lu, Yingwei Pan, Aiqing Yang, Ainiwaer Aikemu, Hao Li, Rongjiao Hao, Qilin Huang, Xin Qi, Zongjian Tao, Yinglong Wu, Cheng Quan, Gangqiao Zhou, Yiming Lu
As two major types of primary liver cancers, the tumor immune microenvironment (TIME) of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) have been well studied separately. However, a systemic assessment of the similarities and differences between the TIME of HCC and ICC is still lacking. In this study, we pictured a landscape of combined TIME of HCC and ICC by sequencing and
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Intratumoral injection of interferon gamma promotes the efficacy of anti-PD1 treatment in colorectal cancer Cancer Lett. (IF 9.7) Pub Date : 2024-03-11 Yang Tang, Jingsun Wei, Xiaoxu Ge, Chengxuan Yu, Wei Lu, Yucheng Qian, Hang Yang, Dongliang Fu, Yimin Fang, Xinyi Zhou, Zhanhuai Wang, Qian Xiao, Kefeng Ding
Immune checkpoint inhibitors (ICIs) offer new options for the treatment of patients with solid cancers worldwide. The majority of colorectal cancers (CRC) are proficient in mismatch-repair (pMMR) genes, harboring fewer tumor antigens and are insensitive to ICIs. These tumors are often found to be immune-deserted. We hypothesized that forcing immune cell infiltration into the tumor microenvironment
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PCTA, a pan-cancer cell line transcriptome atlas Cancer Lett. (IF 9.7) Pub Date : 2024-03-09 Siyuan Cheng, Lin Li, Xiuping Yu
A substantial volume of RNA sequencing data have been generated from cancer cell lines. However, it requires specific bioinformatics skills to compare gene expression levels across cell lines. This has hindered non-bioinformaticians from fully utilizing these valuable datasets in their research. To bridge this gap, we established a curated Pan-cancer Cell Line Transcriptome Atlas (PCTA) dataset. This
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Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction Cancer Lett. (IF 9.7) Pub Date : 2024-03-09 Philip Weidner, Daniel Saar, Michaela Söhn, Torsten Schroeder, Yanxiong Yu, Frank G. Zöllner, Norbert Ponelies, Xiaobo Zhou, André Zwicky, Florian N. Rohrbacher, Vijaya R. Pattabiraman, Matthias Tanriver, Alexander Bauer, Hazem Ahmed, Simon M. Ametamey, Philipp Riffel, Rony Seger, Jeffrey W. Bode, Rebecca C. Wade, Matthias P.A. Ebert, Birthe B. Kragelund, Elke Burgermeister
Inhibition of K-RAS effectors like B-RAF or MEK1/2 is accompanied by treatment resistance in cancer patients via re-activation of PI3K and Wnt signaling. We hypothesized that myotubularin-related-protein-7 (MTMR7), which inhibits PI3K and ERK1/2 signaling downstream of RAS, directly targets RAS and thereby prevents resistance. Using cell and structural biology combined with animal studies, we show
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LRP1 induces anti-PD-1 resistance by modulating the DLL4-NOTCH2-CCL2 axis and redirecting M2-like macrophage polarisation in bladder cancer Cancer Lett. (IF 9.7) Pub Date : 2024-03-08 Hansen Lin, Liangmin Fu, Xinwei Zhou, Anze Yu, Yuhang Chen, Wuyuan Liao, Guannan Shu, Lizhen Zhang, Lei Tan, Hui Liang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Zhenhua Chen, Jinhuan Wei, Jiazheng Cao, Wei Chen, Xiaofei Li, Pengju Li, Jun Lu, Junhang Luo
The tumour microenvironment (TME) drives bladder cancer (BLCA) progression. Targeting the TME has emerged as a promising strategy for BLCA treatment in recent years. Furthermore, checkpoint blockade therapies are only beneficial for a minority of patients with BLCA, and drug resistance is a barrier to achieving significant clinical effects of anti-programmed cell death protein-1 (PD-1)/programmed death
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The mast cell-T lymphocyte axis impacts cancer: Friend or foe? Cancer Lett. (IF 9.7) Pub Date : 2024-03-08 Vinicius Kannen, Denis M. Grant, Jason Matthews
Crosstalk between mast cells (MCs) and T lymphocytes (TLs) releases specific signals that create an environment conducive to tumor development. Conversely, they can protect against cancer by targeting tumor cells for destruction. Although their role in immunity and cancer is complex, their potential in anticancer strategies is often underestimated. When peripheral MCs are activated, they can affect
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Induction of IFIT1/IFIT3 and inhibition of Bcl-2 orchestrate the treatment of myeloma and leukemia via pyroptosis Cancer Lett. (IF 9.7) Pub Date : 2024-03-08 Yuanming He, Shuoyi Jiang, Yaoli Cui, Jingpei Liang, Yueya Zhong, Yuening Sun, Michael F. Moran, Zhenqian Huang, Guisong He, Xinliang Mao
Induction of pyroptosis is proposed as a promising strategy for the treatment of hematological malignancies, but little is known. In the present study, we find clioquinol (CLQ), an anti-parasitic drug, induces striking myeloma and leukemia cell pyroptosis on a drug screen. RNA sequencing reveals that the interferon-inducible genes IFIT1 and IFIT3 are markedly upregulated and are essential for CLQ-induced
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Unlocking c-MET: A comprehensive journey into targeted therapies for breast cancer Cancer Lett. (IF 9.7) Pub Date : 2024-03-08 Parham Jabbarzadeh Kaboli, Hsiao-Fan Chen, Ali Babaeizad, Kiarash Roustai Geraylow, Hirohito Yamaguchi, Mien-Chie Hung
Breast cancer is the most common malignancy among women, posing a formidable health challenge worldwide. In this complex landscape, the c-MET (cellular-mesenchymal epithelial transition factor) receptor tyrosine kinase (RTK), also recognized as the hepatocyte growth factor (HGF) receptor (HGFR), emerges as a prominent protagonist, displaying overexpression in nearly 50% of breast cancer cases. Activation
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A unique circulating microRNA pairs signature serves as a superior tool for early diagnosis of pan-cancer Cancer Lett. (IF 9.7) Pub Date : 2024-03-07 Peng Wu, Dongyu Li, Chaoqi Zhang, Bing Dai, Xiaoya Tang, Jingjing Liu, Yue Wu, Xingwu Wang, Ao Shen, Jiapeng Zhao, Xiaohui Zi, Ruirui Li, Nan Sun, Jie He
Cancer remains a major burden globally and the critical role of early diagnosis is self-evident. Although various miRNA-based signatures have been developed in past decades, clinical utilization is limited due to a lack of precise cutoff value. Here, we innovatively developed a signature based on pairwise expression of miRNAs (miRPs) for pan-cancer diagnosis using machine learning approach. We analyzed
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Potential therapeutic strategy for cancer: Multi-dimensional cross-talk between circRNAs and parental genes Cancer Lett. (IF 9.7) Pub Date : 2024-03-06 Xiaoyu Sun, Xinyi Zhao, Yan Xu, Yuanyuan Yan, Li Han, Minjie Wei, Miao He
In many ways, circular RNAs (circRNAs) have been demonstrated to be crucial in the onset and advancement of cancer throughout the last ten years and have become a new focus of intense research in the field of RNAs. Accumulating studies have demonstrated that circRNAs can regulate parental gene expression a variety of biological pathways. Furthermore, research into the complex interactions between circRNAs
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Association of preoperative aspartate aminotransferase to platelet ratio index with outcomes and tumour microenvironment among colorectal cancer with liver metastases Cancer Lett. (IF 9.7) Pub Date : 2024-03-06 Qichen Chen, Yiqiao Deng, Yuan Li, Jinghua Chen, Rui Zhang, Lang Yang, Rui Guo, Baocai Xing, Peirong Ding, Jianqiang Cai, Hong Zhao
This study aims to investigate applicable robust biomarkers that can improve prognostic predictions for colorectal liver metastasis (CRLM) patients receiving simultaneous resection. A total of 1323 CRLM patients from multiple centres were included. The preoperative aspartate aminotransferase to platelet ratio index (APRI) level from blood of patients were obtained. Patients were stratified into a high
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Molecular mechanisms in regulation of autophagy and apoptosis in view of epigenetic regulation of genes and involvement of liquid-liquid phase separation Cancer Lett. (IF 9.7) Pub Date : 2024-03-06 Subhajit Chakraborty, Piyasa Nandi, Jagdish Mishra, Niharika, Ankan Roy, Soumen Manna, Tirthankar Baral, Prahallad Mishra, Pradyumna Kumar Mishra, Samir Kumar Patra
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Conquering chemoresistance in pancreatic cancer: Exploring novel drug therapies and delivery approaches amidst desmoplasia and hypoxia Cancer Lett. (IF 9.7) Pub Date : 2024-03-06 Pavan Kumar Chintamaneni, Sai Kiran S.S. Pindiprolu, Swati Swagatika Swain, Veera Venkata Satyanarayana Reddy Karri, Jerry Nesamony, Selvam Chelliah, Mahendran Bhaskaran
Pancreatic cancer poses a significant challenge within the field of oncology due to its aggressive behaviour, limited treatment choices, and unfavourable outlook. With a mere 10% survival rate at the 5-year mark, finding effective interventions becomes even more pressing. The intricate relationship between desmoplasia and hypoxia in the tumor microenvironment further complicates matters by promoting
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Tumor-associated macrophages drive glycolysis through the IL-8/STAT3/GLUT3 signaling pathway in pancreatic cancer progression Cancer Lett. (IF 9.7) Pub Date : 2024-03-06 Ziyi Zhong, Kege Yang, Yunlong Li, Shurui Zhou, Hanming Yao, Yue Zhao, Yuzhou Huang, Jinmao Zou, Yaqing Li, Jiajia Li, Guoda Lian, Kaihong Huang, Shaojie Chen
Glycolytic metabolism is a hallmark of pancreatic ductal adenocarcinoma (PDAC), and tumor-associated stromal cells play important roles in tumor metabolism. We previously reported that tumor-associated macrophages (TAMs) facilitate PDAC progression. However, little is known about whether TAMs are involved in regulating glycolysis in PDAC. Here, we found a positive correlation between CD68 TAM infiltration
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Hypoxia effects on glioblastoma progression through YAP/TAZ pathway regulation Cancer Lett. (IF 9.7) Pub Date : 2024-03-06 Carolina Castillo, Maddalena Grieco, Stefania D'Amone, Maria Grazia Lolli, Ornella Ursini, Barbara Cortese
The resistance of glioblastomas (GBM) to standard therapies poses a clinical challenge with limited survival despite interventions. The tumor microenvironment (TME) orchestrates GBM progression, comprising stromal and immune cells and is characterized by extensive hypoxic regions. Hypoxia activates the hypoxia-inducible factor 1 alpha (HIF-1α) pathway, interacting with the Hippo pathway (YAP/TAZ) in
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TGF-β1/SMAD3-driven GLI2 isoform expression contributes to aggressive phenotypes of hepatocellular carcinoma Cancer Lett. (IF 9.7) Pub Date : 2024-03-05 Jia Ding, Yong-Yu Yang, Peng-Tao Li, Yue Ma, Li Zhang, Yuan Zhou, Cheng Jin, Hui-Yan Li, Yuan-Fei Zhu, Xiu-Ping Liu, Zheng-Jin Liu, Hu-Liang Jia, Ping-Guo Liu, Jian Wu
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CRISPR/Cas9 screenings unearth protein arginine methyltransferase 7 as a novel essential gene in prostate cancer metastasis Cancer Lett. (IF 9.7) Pub Date : 2024-03-02 Maria Rodrigo-Faus, Africa Vincelle-Nieto, Natalia Vidal, Javier Puente, Melchor Saiz-Pardo, Alejandra Lopez-Garcia, Marina Mendiburu-Eliçabe, Nerea Palao, Cristina Baquero, Paula Linzoain-Agos, Angel M. Cuesta, Hui-Qi Qu, Hakon Hakonarson, Monica Musteanu, Armando Reyes-Palomares, Almudena Porras, Paloma Bragado, Alvaro Gutierrez-Uzquiza
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Engineered lactococcus lactis intrapleural therapy promotes regression of malignant pleural effusion by enhancing antitumor immunity Cancer Lett. (IF 9.7) Pub Date : 2024-03-02 Yue Fan, Aoxing Chen, Junmeng Zhu, Rui Liu, Yi Mei, Lin Li, Xiaoxuan Sha, Xiaonan Wang, Wei Ren, Lifeng Wang, Baorui Liu
Intrapleural immunotherapies have emerged as a prominent field in treating malignant pleural effusion (MPE). Among these, bacteria-based intrapleural therapy has exerted an anti-MPE effect by immuno-stimulating or cytotoxic properties. We previously engineered a probiotic (FOLactis) expressing a fusion protein of Fms-like tyrosine kinase 3 and co-stimulator OX40 ligands. FOLactis activates tumor antigen-specific
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The stromal microenvironment endows pancreatic neuroendocrine tumors with spatially specific invasive and metastatic phenotypes Cancer Lett. (IF 9.7) Pub Date : 2024-03-02 Zeng Ye, Qiang Li, Yuheng Hu, Haifeng Hu, Junfeng Xu, Muzi Guo, Wuhu Zhang, Xin Lou, Yan Wang, Heli Gao, Desheng Jing, Guixiong Fan, Yi Qin, Yue Zhang, Xuemin Chen, Jie Chen, Xiaowu Xu, Xianjun Yu, Mingyang Liu, Shunrong Ji
Cancer-associated fibroblasts (CAFs) play an important role in a variety of cancers. However, the role of tumor stroma in nonfunctional pancreatic neuroendocrine tumors (NF-PanNETs) is often neglected. Profiling the heterogeneity of CAFs can reveal the causes of malignant phenotypes in NF-PanNETs. Here, we found that patients with high stromal proportion had poor prognosis, especially for that with
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Glutamine inhibition combined with CD47 blockade enhances radiotherapy-induced ferroptosis in head and neck squamous cell carcinoma Cancer Lett. (IF 9.7) Pub Date : 2024-03-01 An Song, Lei Wu, Bo-Xin Zhang, Qi-Chao Yang, Yuan-Tong Liu, Hao Li, Liang Mao, Dian Xiong, Hai-Jun Yu, Zhi-Jun Sun
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Investigating autophagy and intricate cellular mechanisms in hepatocellular carcinoma: Emphasis on cell death mechanism crosstalk Cancer Lett. (IF 9.7) Pub Date : 2024-03-01 Gang Wang, Xiaodi Jiang, Pedram Torabian, Zhi Yang
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K48-linked deubiquitination of VGLL4 by USP15 enhances the efficacy of tumor immunotherapy in triple-negative breast cancer Cancer Lett. (IF 9.7) Pub Date : 2024-02-29 Xuehui Wang, Xiaochong Deng, Jiashu Hu, Wenfang Zheng, Danrong Ye, Xiqian Zhou, Lin Fang
Immunotherapy based on PD-1/PD-L1 antagonists has been demonstrated to be efficacious in inducing tumor remission in patients with triple-negative breast cancer (TNBC). However, tumor immune evasion caused by the PD-1/PD-L1 pathway inhibits the immunotherapeutic effect of PD-1/PD-L1 inhibitors against TNBC. Therefore, identifying potential targets for blocking the PD-1/PD-L1 pathway is a compelling
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Improved antitumor effects elicited by an oncolytic HSV-1 expressing a novel B7H3nb/CD3 BsAb Cancer Lett. (IF 9.7) Pub Date : 2024-02-29 Zongliang Zhang, Nian Yang, Huaqing Lu, Yongdong Chen, Long Xu, Zeng Wang, Qizhong Lu, Kunhong Zhong, Zhixiong Zhu, Guoqing Wang, Hexian Li, Meijun Zheng, Weiwei Zhang, Hui Yang, Xingchen Peng, Liangxue Zhou, Aiping Tong
Oncolytic viruses have emerged as a promising modality for cancer treatment due to their unique abilities to directly destroy tumor cells and modulate the tumor microenvironment. Bispecific T-cell engagers (BsAbs) have been developed to activate and redirect cytotoxic T lymphocytes, enhancing the antitumor response. To take advantage of the specific infection capacity and carrying ability of exogenous
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Pharmacological approaches for targeting lysosomes to induce ferroptotic cell death in cancer Cancer Lett. (IF 9.7) Pub Date : 2024-02-29 Ji Feng, Zi-Xuan Wang, Jin-Lian Bin, Yong-Xin Chen, Jing Ma, Jing-Huan Deng, Xiao-Wei Huang, Jing Zhou, Guo-Dong Lu