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Early growth response 1 regulates dual‑specificity protein phosphatase 1 and inhibits cell migration and invasion of tongue squamous cell carcinoma. Oncol. Lett. (IF 2.9) Pub Date : 2024-04-03 Longxun Zhou, Yuqun Shan, Jun Li, Min Li, Zhen Meng, Na Guo
Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors in the head and neck, and among the OSCCs, tongue squamous cell carcinoma (TSCC) is one of the most common types. Although therapy strategies have recently advanced, the prognosis of TSCC has not substantially improved. Metastasis is one of the main causes of patient mortality in TSCC; therefore, it is necessary to elucidate
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Efficacy of consolidation of immune checkpoint inhibitor after chemoradiation for unresectable, locally advanced PD‑L1 negative non‑small cell lung cancer: A systematic review and meta‑analysis. Oncol. Lett. (IF 2.9) Pub Date : 2024-04-03 Sunyin Rao, Li Min, Jie Zhao, Juan Su, Lianhua Ye
Chemoradiotherapy (CRT) followed by consolidation of immune checkpoint inhibitors (ICIs), such as durvalumab or pembrolizumab, for patients with unresectable, locally advanced non-small cell lung cancer (NSCLC) with tumor PD-L1 expression <1% remains a topic of controversy. Previous studies from PubMed, Cochrane Library and Embase databases were searched for a meta-analysis. A total of 16 studies were
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Prognostic significance of connective tissue growth factor expression in stromal cells in patients with diffuse‑type gastric cancer. Oncol. Lett. (IF 2.9) Pub Date : 2024-04-03 Yuichiro Miki, Mami Yoshii, Ryoko Miyauchi, Hiroaki Kasashima, Tatsunari Fukuoka, Tatsuro Tamura, Masatsune Shibutani, Takahiro Toyokawa, Shigeru Lee, Masakazu Yashiro, Kiyoshi Maeda
Connective tissue growth factor (CTGF) is a target gene of the Hippo signaling pathway. Its differential role in the histological types of gastric cancer (GC) remains unknown; therefore, the present study aimed to confirm the clinical significance of CTGF expression in cancer and stromal cells in patients with GC depending on the histological type. The present study enrolled 589 patients with GC.
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[Retracted] Downregulation of long non‑coding RNA GAS5 promotes cell proliferation, migration and invasion in esophageal squamous cell carcinoma. Oncol. Lett. (IF 2.9) Pub Date : 2024-04-02 Ke Ke, Zhanwen Sun, Zhengjun Wang
[This retracts the article DOI: 10.3892/ol.2018.8797.].
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Assessment and prognostic significance of a serum cytokine panel in diffuse large B‑cell lymphoma. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-28 Shufang Xie, Lifen Zhu, Lei Wang, Shibing Wang, Xiangmin Tong, Wanmao Ni
The objective of the present study was to assess the levels of circulating cytokines in patients with diffuse large B-cell lymphoma (DLBCL), and to examine the associations between the cytokine levels, clinicopathological manifestations and patient prognosis. The study enrolled 49 patients with DLBCL, 11 patients with chronic lymphocytic leukemia/small lymphocytic lymphoma and 67 healthy controls from
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Glycolysis‑related lncRNA may be associated with prognosis and immune activity in grade II‑III glioma. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-28 Tao Yang, Ruiguang Zhang, Zhenfen Cui, Bowen Zheng, Xiaowei Zhu, Xinyu Yang, Qiang Huang
Glucose metabolism, as a novel theory to explain tumor cell behavior, has been intensively studied in various tumors. The present study explored the long non-coding RNAs (lncRNAs) related to glycolysis in grade II-III glioma, aiming to provide a promising target for further research. Pearson correlation analysis was used to identify glycolysis-related lncRNAs. Univariate/multivariate Cox regression
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Postoperative long‑term outcomes of acute normovolemic hemodilution in pancreatic cancer: A propensity score matching analysis. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-27 Taiichi Wakiya, Keinosuke Ishido, Norihisa Kimura, Hayato Nagase, Taishu Kanda, Shunsuke Kubota, Hiroaki Fujita, Yoshiya Takahashi, Takeshi Yamamoto, Kohei Chida, Junichi Saito, Kazuyoshi Hirota, Kenichi Hakamada
Acute normovolemic hemodilution (ANH) is a useful intraoperative blood conservation technique. However, the impact on long-term outcomes in pancreatic ductal adenocarcinoma (PDAC) remains unclear. The present study investigated the impact of ANH on long-term outcomes in patients with PDAC undergoing radical surgery. Data from 155 resectable PDAC cases were collected. Patients were categorized according
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Circulating tumor cells help differentiate benign ovarian lesions from cancer before surgery: A literature review and proof of concept study using flow cytometry with fluorescence imaging. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-26 Yung-Chia Kuo, Chi-Hsi Chuang, Hsuan-Chih Kuo, Cheng-Tao Lin, Angel Chao, Huei-Jean Huang, Hung-Ming Wang, Jason Chia-Hsun Hsieh, Hung-Hsueh Chou
Current tools are insufficient for distinguishing patients with ovarian cancer from those with benign ovarian lesions before extensive surgery. The present study utilized a readily accessible platform employing a negative selection strategy, followed by flow cytometry, to enumerate circulating tumor cells (CTCs) in patients with ovarian cancer. These counts were compared with those from patients with
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Fusobacteria alterations are associated with colorectal cancer liver metastasis and a poor prognosis. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-26 Min Jin, Qilin Fan, Fumei Shang, Tao Zhang, Shuji Ogino, Hongli Liu
Liver metastasis is a major cause of mortality in patients with advanced stages of colorectal cancer (CRC). The gut microbiota has been demonstrated to influence the progression of liver diseases, potentially providing novel perspectives for diagnosis, treatment and research. However, the gut microbial characteristics in CRC with liver metastasis (LM) and with no liver metastasis (NLM) have not yet
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Diagnostic value of HPV E6/E7 mRNA in screening for cervical intraepithelial neoplasia grade 2 or worse: A systematic review and meta‑analysis. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-26 Fengsheng Xu, Tianfu Ran, Qiangang Wei, Rirun Pan, Shangzhong Chen, Jing Luo
Histology is considered the gold standard for diagnosing the pathological progress of cervical cancer development, while cervical intraepithelial neoplasia of grade 2 or worse (CIN2+) is the cutoff for intervention in clinical practice. The diagnostic value of human papillomavirus (HPV) E6/E7 mRNA in screening for CIN2+ has not been systematically summarized. A meta-analysis was conducted as part of
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[Retracted] Predictors of efficacy of anamorelin in patients with non‑small cell lung cancer and cachexia: A retrospective study. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-26 Yoshiko Ishioka, Hisashi Tanaka, Tomonori Makiguchi, Syunsuke Fujishima, Yasuhito Nunomura, Hiroaki Sakamoto, Toshihiro Shiratori, Kageaki Taima, Sadatomo Tasaka
[This retracts the article DOI: 10.3892/ol.2023.14154.].
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Skipped sentinel lymph node basin in a patient with forearm cutaneous melanoma: A case report. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-26 Olivier F Noel, James Clune
Sentinel lymph node biopsy is an important tool in the management of malignant melanoma, particularly in predicting micrometastasis to regional lymph nodes. Cases of secondary drainage to lymph nodes outside of conventional nodal basins and overall unusual lymph node localization have been reported. The present study reports a unique case of a 'skipped sentinel lymph node basin' pattern in a patient
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FOXP2 inhibits the aggressiveness of lung cancer cells by blocking TGFβ signaling. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-26 Wenya Su, Song Hu, Lin Zhou, Hui Bi, Zhiying Li
Lung cancer is associated with high morbidity and mortality rates. Forkhead box P2 (FOXP2) functions as an antitumor gene in various cancers. However, its role in lung cancer remains to be elucidated. The present study explored the potential role of FOXP2 in lung cancer. mRNA levels and protein expression were determined using RT-qPCR and western blotting, respectively. Functional analysis was performed
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Low‑dose venetoclax combined with azacitidine in older and frail patients with newly diagnosed acute myeloid leukaemia. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-26 Chunmeng Rong, Fang Yang, Yalu Chen, Ming Wang, Cheng Ai, Yuqing Luo, Panpan Gao, Yiqin Weng, Xiaguang Huang, Meier Gu, Weiping Huang, Yongming Xia
In the present study, the aim was to evaluate the clinical efficacy and safety of low-dose venetoclax combined with azacitidine for the treatment of older and frail patients with newly diagnosed acute myeloid leukaemia (AML). Data of 26 older patients with newly diagnosed AML admitted to Yuyao People's Hospital (Yuyao, China) between January 2021 and May 2023 were retrospectively analysed. The treatment
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Drug resistance‑related gene targets and molecular mechanisms in the A2780/Taxol‑resistant epithelial ovarian cancer cell line. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-26 Ruihui Yang, Huainian Zhang, Zexin Chen, Tao Zhang, Peng Wei, Huaguo Liang, Yaoyao He, Changtao Zheng, Xicheng Wang, Yongli Zhang
Epithelial ovarian cancer (EOC) is a fatal gynecological malignant tumor with a low 5-year survival rate. The use of the first-line chemotherapeutic drug, paclitaxel, for the treatment of EOC is associated with resistance, often leading to treatment failure. The present study investigated the gene targets in an A2780 paclitaxel-resistant EOC cell line (A2780/Taxol), and the potential underlying mechanisms
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Ketogenic metabolic therapy in conjunction with standard treatment for glioblastoma: A case report. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-26 Matthew C L Phillips, Ziad Thotathil, Prashanth Hari Dass, Fouzia Ziad, Ben G Moon
Glioblastoma (GBM) is the most common primary malignant brain tumour in adults. The standard of care consists of surgical resection and concurrent chemoradiation, followed by adjuvant temozolomide chemotherapy. This protocol is associated with a median survival of 12-15 months, and <5% of patients survive >3 years. Ketogenic metabolic therapy (KMT) targets cancer cell metabolism by restricting glucose
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Molecular mechanism of formation and destruction of a pseudo‑capsule in clear cell renal cell carcinoma. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-22 Takuto Shimizu, Makito Miyake, Kota Iida, Sayuri Onishi, Tomomi Fujii, Yusuke Iemura, Kazuki Ichikawa, Chihiro Omori, Fumisato Maesaka, Mitsuru Tomizawa, Tatsuki Miyamoto, Nobumichi Tanaka, Kiyohide Fujimoto
The process and molecular mechanisms underlying the formation and destruction of a pseudo-capsule (PC) in clear cell renal cell carcinoma (ccRCC) are poorly understood. In the present study, the PCs of surgical specimens from primary tumors and metastatic lesions in 169 patients with ccRCC, and carcinogen-induced ccRCC rat models were semi-quantified using the invasion of PC (i-Cap) score system. This
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Simultaneous blastic plasmacytoid dendritic cell neoplasm and myelofibrosis: A case report. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-22 Fuyi Luo, Bingjie Li, Jing Li, Yan Li
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an extremely rare and aggressive tumor with an unknown pathogenesis. Myelofibrosis (MF) is a type of myeloproliferative neoplasm. MF can be secondary to several hematological malignancies, including chronic myeloid leukemia, myelodysplastic syndrome and hairy cell leukemia. In the present report, a rare case of BPDCN secondary to MF is described
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LncRNA HOXA‑AS2 is a prognostic and clinicopathological predictor in patients with cancer: A meta‑analysis. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-22 Tijun Xiao, An Yan, Lifang Tan, Hongwei Zhu, Wenzhe Gao
Elevated expression of long non-coding RNA homeobox A cluster antisense RNA 2 (lncRNA HOXA-AS2) is known to have prognostic value in various solid tumors. The present meta-analysis aimed to comprehensively quantify its prognostic significance across a wider spectrum of malignancies and to provide an updated synthesis of evidence that could refine prognostic models. To achieve this aim, multiple databases
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MicroRNA‑373‑3p inhibits the proliferation and invasion of non‑small‑cell lung cancer cells by targeting the GAB2/PI3K/AKT pathway. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-22 Xunxia Zhu, Xiaoyu Chen, Xuelin Zhang, Liting Zhao, Xiaoyong Shen
MicroRNAs (miRNAs) were previously demonstrated to be involved in the pathogenesis of non-small-cell lung cancer (NSCLC); however, the roles of certain miRNAs in NSCLC remain to be elucidated. The present study aimed to investigate the functions of screened miRNAs in NSCLC and the potential mechanisms. First, expression profiles of miRNAs were downloaded from the Gene Expression Omnibus (dataset no
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Efficacy and survival outcomes of alectinib vs. crizotinib in ALK‑positive NSCLC patients with CNS metastases: A retrospective study. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-22 Qing Liu, Ying Fu, Jun Guo, Chunqiu Fu, Ning Tang, Chufeng Zhang, Xiao Han, Zhehai Wang
Anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) have transformed the treatment paradigm for patients with ALK-positive non-small cell lung cancer (NSCLC). Yet the differential efficacy between alectinib and crizotinib in treating patients with NSCLC and central nervous system (CNS) metastases has been insufficiently studied. A retrospective analysis was conducted of clinical outcomes
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Successful treatment of severe splenic lymphoma‑associated hemophagocytic syndrome by splenectomy and subsequent chemotherapy: A case report. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-22 Hideyuki Masui, Maki Shindo, Yuta Inoue, Maki Sugiyama, Atsushi Ueda, Takero Shindo, Kae Okoshi, Koichi Kinoshita
Hemophagocytic lymphohistiocytosis (HLH) represents a fatal immunopathology derived from excessive inflammatory reactions. In particular, lymphoma-associated hemophagocytic syndrome (LAHS) is associated with a dismal prognosis. The current study presented a challenging case of splenic LAHS. A 71-year-old man presented with fatigue and anorexia. Laboratory test results revealed anemia, thrombocytopenia
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A fully validated LC‑MS/MS method for quantifying bevacizumab in plasma samples from patients with NSCLC and its implications in therapeutic drug monitoring. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-22 Bo Li, Meng Yang, Xiaoxue Wang, Wenqian Chen, Hongkai Lu, Guan Wang, Liang Sun, Xiaoyang Liu, Xianbo Zuo, Pengmei Li, Lihong Liu, Xianglin Zhang
Given the increasing use of bevacizumab in combinatorial drug therapy for a multitude of different cancer types, there is a need for therapeutic drug monitoring to analyze the possible correlation between drug trough concentration, and therapeutic effect and adverse reactions. An ultra-performance liquid chromatography tandem-mass spectrometry method was then developed and validated to determine bevacizumab
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Internal mammary node abnormality in imaging studies and treatment outcomes in patients with breast cancer. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-21 Kenji Makita, Yasushi Hamamoto, Hiromitsu Kanzaki, Kei Nagasaki, Kenjiro Aogi
The clinical significance of mild internal mammary node (IMN) enlargement (Mild-IMN) is uncertain. This study aimed to evaluate the relationship between treatment outcomes and IMN status in patients with breast cancer who underwent postmastectomy radiation therapy between January 2010 and December 2018. Overall, 250 patients were categorized based on IMN status: Clinically normal IMN (Normal-IMN; n=172)
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Intrapleural perfusion hyperthermia improves the efficiency of anti‑PD1 antibody‑based therapy for lung adenocarcinoma: A case report. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-21 Xiaolei Wang, Jin Song, Ling Hu, Guanying Ren, Nan Geng, Zizheng Song
Chemotherapy based on intrapleural perfusion hyperthermia (IPH) can markedly improve the sensitivity of lung adenocarcinoma cells to anti-programmed cell death receptor 1 (PD1) antibody adjuvant chemotherapy and enhance the clinical response of a patient. In the present study, a unique case of a patient who failed to respond to immunotherapy combined with chemotherapy but achieved prolonged stable
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hsa‑miR‑455‑3P as a predictive biomarker of anemia in patients with non‑small cell lung cancer treated with carboplatin plus paclitaxel. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-21 Pedro Eduardo Nascimento Silva Vasconcelos, Cecília Souto Seguin, Aristóteles de Souza Barbeiro, Lair Zambon, Helen Naemi Honma, Maurício Wesley Perroud, Murilo Vieira Geraldo, Eder de Carvalho Pincinato, Patricia Moriel
Lung cancer is the leading cause of cancer-related morbidity and mortality worldwide. The initial treatment of lung cancer depends on the definition of the tumor type and its staging. The most common treatment is chemotherapy, and the first-line treatment is a combination of carboplatin and paclitaxel. Although this treatment has good efficacy, there is a high prevalence of adverse events, particularly
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Effect of different preoperative nutritional treatments on postoperative recovery and clinical outcomes in patients with gastric cancer and early gastric outlet obstruction. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-19 Caixia Wang, Dameng Yang
Patients with gastric cancer and early gastric outlet obstruction often experience malnutrition and require various nutritional support strategies. This study aimed to evaluate the impact of different preoperative nutritional treatments on their postoperative recovery and prognosis. The present retrospective study collected data from 467 patients with gastric cancer and early gastric outlet obstruction
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[Retracted] Serum miR‑338‑5p has potential for use as a tumor marker for retinoblastoma. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-19 Peng Zhou, Xuemin Li
[This retracts the article DOI: 10.3892/ol.2019.10331.].
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PYCR1 regulates TRAIL‑resistance in non‑small cell lung cancer cells by regulating the redistribution of death receptors. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-19 Chengcheng You, Jinlan He, Chunyu Cao, Deqiao Sheng, Lin Wang, Zhixian Huang, Xiaoling Zhang, Changjun Yi, Yingming Sun, Yiling Huang
Although recombinant human TNF-related apoptosis-inducing ligand (TRAIL) protein exhibits antitumor activity in a number of lung and liver cancer cells and tumor-bearing animals, TRAIL resistance has substantially restricted its clinical application. Pyrroline-5-carboxylate reductase 1 (PYCR1) is a key enzyme in the regulation of proline synthesis. PYCR1 is highly expressed in various types of malignant
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Clinicopathological features of cholangiolocarcinoma and impact of tumor heterogeneity on prognosis: A single institution retrospective study. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-15 Hiroaki Sugita, Shinichi Nakanuma, Ryosuke Gabata, Tomokazu Tokoro, Ryohei Takei, Mitsuyoshi Okazaki, Kaichiro Kato, Satoshi Takada, Isamu Makino, Kazuto Kozaka, Kenichi Harada, Shintaro Yagi
Cholangiolocarcinoma (CLC) is an extremely rare tumor classified as a subtype of small duct-type intrahepatic cholangiocarcinoma (iCCA). There are few detailed reports on CLC and the prognostic impact of tumor heterogeneity is not clear. Between April 2006 and June 2022, of the 774 primary liver cancer resection cases who presented at Kanazawa University Hospital, 14 patients were pathologically diagnosed
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The expression of trefoil factor family member 2 in increased at an acidic pH. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-15 Yui Masumoto, Suzuka Matsuo, Natsuno Kinjou, Yuka Narieda, Morimasa Wada, Kyoko Fujimoto
Trefoil factor family member 2 (Tff2) is significantly involved in intestinal tumor growth in ApcMin/+ mice, which can be used as a human colon cancer model. TFF2, which encodes TFF2 (spasmolytic protein 1) is highly expressed in human cancer tissues, including the pancreas, colon and bile ducts, as well as in normal gastric and duodenum tissues. By contrast, TFF2 exhibits low expression levels in
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p160 nuclear receptor coactivator family members and their role in rare fusion‑driven neoplasms (Review). Oncol. Lett. (IF 2.9) Pub Date : 2024-03-14 Danilo Segovia, Polona Safaric Tepes
Gene fusions with translocations involving nuclear receptor coactivators (NCoAs) are relatively common among fusion-driven malignancies. NCoAs are essential mediators of environmental cues and can modulate the transcription of downstream target genes upon binding to activated nuclear receptors. Therefore, fusion proteins containing NCoAs can become strong oncogenic drivers, affecting the cell transcriptional
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Secondary hematological malignancies in patients with sarcoma: A single‑center retrospective study. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-14 Yoon Jung Jang, Hong Kyu Jeong, Chang-Bae Kong, Won Seok Song, Wan Hyeong Cho, Dae Geun Jeon, Heyjin Kim, Sung Hyun Yang, Im Il Na, Hyo-Rak Lee, Hye Jin Kang
The present retrospective study investigated the clinical features and prognosis of secondary hematological malignancies (SHMs) in patients with sarcoma at Korea Cancer Center Hospital (Seoul, South Korea). Patients who had been diagnosed with SHMs after having received treatment for sarcoma between January 2000 and May 2023 were enrolled. Clinical data were collected from the patients' medical records
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Use of ultra-high performance liquid chromatography-high-resolution mass spectroscopy to profile the metabolites from the serum of patients with breast cancer. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-14 Qinqin Zhang, Rongzhao Lu, Ying Wu, Yong Hong, Ningxia Wang, Cunchuan Wang
Breast cancer (BC) is the most common type of malignancy and the leading cause of cancer-associated mortality in women worldwide. As such, assessing the metabolic changes during human breast carcinogenesis is key for developing disease prevention methods and treatment. In the present study, non-targeted metabolomics with chemometrics based on ultra-high performance liquid chromatography-high-resolution
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Misdiagnosis of multiple myeloma as postoperative bone metastasis of rectal cancer: A case report and literature review. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-14 Yuanqi Huang, Zhengquan Chen, Kunming Wen
Multiple myeloma (MM) and bone metastases are both common malignant tumors of the skeleton that share similar clinical manifestations and radiological features. The development of MM following rectal cancer surgery is relatively rare in clinical practice and is easily misdiagnosed as bone metastasis. The present study reported on a patient with MM and postoperative rectal cancer. A 65-year-old man
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Characteristics and prognostic value of gut microbiota in follicular lymphoma. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-13 Zhuo-Fan Xu, Danqing Zhao, Chong Wei, Wei Wang, Yan Zhang, Wei Zhang, Daobin Zhou
The pathogenesis and progression of follicular lymphoma (FL) depends on immune evasion mechanisms. The gut microbiota has been reported to be associated with the development and outcome of several human diseases by modulating host immunity. Thus, the present study investigated the characteristics and prognostic value of the gut microbiota in FL. Fecal samples from treatment-naïve patients with FL (n=28)
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Urothelial carcinoma masquerading as retroperitoneal fibrosis: A case report. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-05 David Luengo, Ángela Salmerón, Antonio Medina, Javier Pastor, Mercedes Caba
Retroperitoneal fibrosis, a rare and often idiopathic condition, poses significant diagnostic challenges. While most cases are considered idiopathic or immune-mediated, a small but important proportion are associated with malignant neoplasms, with implications for prognosis and management. The present study describes the case of a 69-year-old man who presented to the emergency department of the Virgen
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Apatinib plus chemotherapy is associated with an improved tumor response, survival and tolerance compared with chemotherapy alone for advanced lung adenocarcinoma treatment. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-05 Hua Ye, Wenwen Yu, Yangyang Ni, Xiaoqiong Bao, Xie Zhang, Yunlei Li, Ali Chen, Jifa Li, Long Zheng
Apatinib plus chemotherapy demonstrates good efficacy in multiple advanced carcinomas; however, its use in patients with advanced lung adenocarcinoma (LUAD) has not yet been assessed. The present study evaluated the potential benefits of apatinib plus chemotherapy in patients with advanced LUAD. A total of 145 patients with advanced LUAD and negative driver genes who received apatinib plus chemotherapy
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Safety and efficacy of pyrotinib for HER‑2‑positive breast cancer in the neoadjuvant setting: A systematic review and meta‑analysis. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-04 Qian Ma, Bai Wei, Bi-Cheng Wang, Ganxin Wang, Xuan Zhou, Yan Wang
As a novel tyrosine kinase inhibitor (TKI), pyrotinib can irreversibly block dual pan-ErbB receptors and has been used in the treatment of advanced or metastatic human epidermal growth factor receptor 2 (HER2)-positive breast cancer. However, there are limited data on the use of pyrotinib in early breast cancer. Therefore, the present meta-analysis was conducted to evaluate the safety and efficacy
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Prognostic biomarker HIF1α and its correlation with immune infiltration in gliomas. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-04 Zihan Ding, Jiaming Zhang, Lin Li, Chunliang Wang, Jinhong Mei
Certain glioma subtypes, such as glioblastoma multiforme or low-grade glioma, are common malignant intracranial tumors with high rates of relapse and malignant progression even after standard therapy. The overall survival (OS) is poor in patients with gliomas; hence, effective prognostic prediction is crucial. Herein, the present study aimed to explore the potential role of hypoxia-inducible factor
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[Retracted] Correlation of SOX9 and NM23 genes with the incidence and prognosis of prostate cancer. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-04 Ming Xi, Song Wan, Wei Hua, Yulin Zhou, Wencong Jiang, Jianxin Hu
[This retracts the article DOI: 10.3892/ol.2018.9828.].
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Integrative analysis and risk model construction for super‑enhancer‑related immune genes in clear cell renal cell carcinoma. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-01 Zhenyu Bi, Jinghao Zhou, Yan Ma, Qingxin Guo, Boyang Ju, Haoran Zou, Zuhao Zhan, Feihong Yang, Han Du, Xiuguo Gan, Erlin Song
Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer associated with poor prognosis, and accounts for the majority of RCC-related deaths. The lack of comprehensive diagnostic and prognostic biomarkers has limited further understanding of the pathophysiology of ccRCC. Super-enhancers (SEs) are congregated enhancer clusters that have a key role in tumor processes such as
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Prognostic value of tumor‑associated CD177+ neutrophils in lung adenocarcinoma. Oncol. Lett. (IF 2.9) Pub Date : 2024-03-01 Jinhua Zhou, Qingxia Xu, Huan Liu, Jianlong Miao, Cuixia Bian, Yutao Wei, Wei Wang, Shulong Jiang
The aim of the present study was to detect CD177+ neutrophils in tumor tissues and analyze their association with the clinical characteristics and prognosis of patients with lung adenocarcinoma (LUAD). Immunohistochemistry was used to detect CD177+ neutrophils in tumors and adjacent tissues of 16 patients with LUAD who underwent curative surgical resection. A total of 120 patients with LUAD were recruited
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Diagnostic performance of 18F‑DCFPyL PET vs. 68Ga‑PSMA PET/CT in patients with suspected prostate cancer: A systemic review and meta‑analysis. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-29 Zhibing Jiang, Jinjing Guo, Liang Hu, Siyu Yang, Bin Meng, Qun Tang
In this systematic review and meta-analysis, the diagnostic performance of 68Ga-prostate-specific membrane antigen (PSMA) positron emission tomography (PET)/CT was compared with that of 18F-DCFPyL PET for patients with suspected prostate cancer (PCa). Up to September 2023, the PubMed, Embase and Web of Science databases were thoroughly searched for relevant papers. Studies examining the diagnostic
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Adrenal ganglioneuroblastoma with metastasis near the renal hilum in an adult female: A case report and review of the literature. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-29 Xinzhang Zhang, Yiwen Zhang, Dan Peng, Xin Shi, Zhuorui Zhang, Junfeng Wang, Xue Zhang, Jinjun Leng, Wei Li
Ganglioneuroblastoma (GNB), predominantly observed in children, is an uncommon malignant tumor in adults, with established treatment protocols notably lacking. The present study details the case of a 20-year-old woman who presented with a left adrenal gland mass, identified during a physical examination. Additionally, an unidentified mass was noted near the renal hilum in the preoperative evaluation
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Identification and prognostic analysis of ferroptosis‑related gene HSPA5 to predict the progression of lung squamous cell carcinoma. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-29 Di Guo, Yonghai Feng, Peijie Liu, Shanshan Yang, Wenfei Zhao, Hongyun Li
Ferroptosis, an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, is implicated in the development and therapeutic responses of cancer. However, the role of ferroptosis-related gene profiles in lung squamous cell carcinoma (LSCC) remains largely unknown. The present study aimed to identify the prognostic roles of ferroptosis-related genes in LSCC. Sequencing data from
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Cushing's syndrome caused by adrenocortical oncocytoma: A case report. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-28 Chengren Gou, Qingsong Jian, Maoqiang Tian, Jinghai Li, Yi Zhang, Zhenyu Guo
Adrenal cortical eosinophilic adenoma usually presents as non-functional adrenal tumor but may lead to Cushing's syndrome in patients. The present article reports a patient with Cushing's syndrome caused by right adrenocortical oncocytoma. The patient was treated in Urology Department of Wuchuan People's Hospital (Zunyi, China) in November 2022 because of hirsutism, weight gain and hypertension. A
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Influence of Zika virus on the cytotoxicity, cell adhesion, apoptosis and inflammatory markers of glioblastoma cells. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-28 Daniel Rodrigo Marinowic, Gabriele Goulart Zanirati, Pamella Nunes Azevedo, Ângela Zanatta, Ismael Plentz, Allan Marinho Alcará, Fernanda Bueno Morrone, Thamiris Becker Scheffel, Angélica Regina Cappellari, Paulo Michel Roehe, Ana Paula Muterle Varela, Denise Cantarelli Machado, Fabiana Spillari Viola, Jaderson Costa Da Costa
Glioblastoma (GBM) is one of the most common types of brain tumor in adults. Despite the availability of treatments for this disease, GBM remains one of the most lethal and difficult types of tumors to treat, and thus, a majority of patients die within 2 years of diagnosis. Infection with Zika virus (ZIKV) inhibits cell proliferation and induces apoptosis, particularly in developing neuronal cells
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Association between the MDR1 rs1045642 polymorphism and breast cancer risk: An updated meta‑analysis. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-28 Lili Gong, Gang Hu, Lihua Xu, Yajuan Chen, Na Wang
Multidrug resistance 1 (MDR1) is a transmembrane transporter on the cell membrane. As an ATP-dependent efflux pump, MDR1 is mainly responsible for the adsorption, distribution, metabolism, excretion and transportation of anticancer drugs to cancer cells. Mutations of the MDR1 gene may be associated with the incidence of cancer. In the past decade, associations found between the MDR1 rs1045642 polymorphism
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The landscape of 8q24 cytoband in gastric cancer (Review). Oncol. Lett. (IF 2.9) Pub Date : 2024-02-28 Violeta Larios-Serrato, Hilda-Alicia Valdez-Salazar, Martha-Eugenia Ruiz-Tachiquín
Worldwide, gastric cancer (GC) is estimated to be the fifth most common type of cancer type in both sexes, ranking sixth for new cases, with >640,850 cases per year, and fourth in terms of mortality rate. Cancer presents numerical and structural alterations in chromosomes, often through gains and losses of regions. In GC, there are multiple genetic alterations, in which those located in cytoband 8q24
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Liquid biopsy utilizing miRNA in patients with advanced breast cancer treated with cyclin‑dependent kinase 4/6 inhibitors. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-28 Marcin Kubeczko, Patrycja Tudrej, Tomasz Tyszkiewicz, Aleksandra Krzywon, MaŁgorzata Oczko-Wojciechowska, MichaŁ JarzĄb
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6is) are the mainstay of treatment of hormone receptor+/human epidermal growth factor receptor 2-patients with advanced breast cancer (ABC). Despite improvements in overall survival, most patients experience disease progression. Biomarkers derived from a liquid biopsy are appealing for their potential to detect resistance to treatment earlier than computed
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Multi‑parameter quantitative magnetic resonance imaging in the early assessment of radiation‑induced parotid damage in patients with nasopharyngeal carcinoma following intensity‑modulated radiotherapy. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-28 Xianhai Zhang, Zhifeng Xu, Yabin Jin, Linwen Huang, Wenxiu Wu, Mingyong Gao
The present study aimed to investigate the value of intravoxel incoherent motion imaging (IVIM) and three-dimensional pulsed continuous arterial spin labeling (ASL) in assessing dynamic changes of the parotid gland in patients with nasopharyngeal carcinoma (NPC) following radiotherapy (RT). A total of 18 patients with NPC who underwent intensity-modulated RT were enrolled in the present study. All
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[Retracted] miR‑133b induces chemoresistance of osteosarcoma cells to cisplatin treatment by promoting cell death, migration and invasion. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-26 Yonggen Zou, Jiexiang Yang, Jian Wu, Cheng Luo, Yuanshuai Huang
[This retracts the article DOI: 10.3892/ol.2017.7432.].
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A meta‑ and bioinformatics analysis of maspin expression levels influencing the prognosis of patients with breast cancer. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-23 Shuai Shi, Zhi-Gang Zhang, Yin-Zhou Sang, Jie Sun, Hong-Yan Ma
Maspin is a serine protease inhibitor that is encoded by the human SERPINB5 gene. As a tumor inhibitor, it can inhibit the growth of tumor cells, increase adhesion between tumor cells and inhibit tumor angiogenesis. In the present study, a meta- and bioinformatics analysis was performed through the PubMed and China National Knowledge Infrastructure databases including entries added until up to March
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Fisetin enhances cisplatin sensitivity in renal cell carcinoma via the CDK6/PI3K/Akt/mTOR signaling pathway. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-20 Tingting Jiang, Yan Liang, Yenan Ji, Yin Xue
Cisplatin resistance is ubiquitous among patients with renal cell carcinoma (RCC). The present study assessed the role of fisetin in regulating cisplatin sensitivity and increasing the efficacy of chemotherapy for patients with RCC. Cell Counting Kit-8 and colony formation assays were used to assess the proliferation of RCC cells after fisetin and cisplatin treatment. The mRNA expression levels of
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Myelodysplastic syndrome with IgG4‑related disease: A case report. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-20 Lina Wang, Xi Pang, Zirui Hong, Baodong Ye, Zhiping Hu, Chunli Zhang, Shuyan Liu
At present, to the best of our knowledge, there are only a few case reports of IgG4-related disease (IgG4-RD) involving myelodysplastic syndrome (MDS), yet the incidence of MDS and IgG4-RD is increasing in middle-aged and elderly people. The present study presents a case of MDS combined with IgG4-RD admitted to Zhejiang Provincial Hospital of Chinese Medicine in September 2022. The (66-year-old; male)
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[Retracted] Long non‑coding RNA MALAT‑1 contributes to maintenance of stem cell‑like phenotypes in breast cancer cells. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-19 Linghuan Zeng, Ying Cen, Junjie Chen
[This retracts the article DOI: 10.3892/ol.2017.7557.].
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Indolent growth of low‑grade myofibroblastic sarcoma of the knee with the resemblance of a benign lesion: A case report. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-19 Tao Cheng, Shaohua Liang, Jinli Zhang, Wen Wang
Low-grade myofibroblastic sarcoma (LGMS) is a rare soft-tissue malignant neoplasm originating from the stromal cells that is predominantly comprised of atypical myofibroblasts. The present study reports the case of a patient with low-grade myofibroblastic sarcoma in the soft tissue of the knee. The patient exhibited a soft, painless mass on the medial side of the left knee. During surgery, a yellow-white
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Prognostic role of primary tumor size in Wilms tumor. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-19 Kai Li, Ke Zhang, Hexing Yuan, Caibin Fan
Wilms tumor (WT) is the most common childhood malignant kidney tumor. The aim of the present study was to determine the impact of primary tumor size on the survival of patients with WT. The data of 1,523 patients diagnosed with WT between 2000 and 2017 were retrieved from the Surveillance, Epidemiology, and End Results database. Receiver operating characteristic curves were plotted to determine the
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Repeated high‑intensity focused ultrasound combined with iodine‑125 seed interstitial brachytherapy offers improved quality of life and pain control for patients with advanced pancreatic cancer: A 52‑patient retrospective study. Oncol. Lett. (IF 2.9) Pub Date : 2024-02-16 Yumei Liu, Yongshuo Ji, Junqiu Zhu, Linglin Zhu, Yanfei Zhu, Zhijun Bao, Hong Zhao
Patients diagnosed with pancreatic cancer who have 5-year survival rates of ~5% are typically in the advanced stage. Pancreatic cancer has become the third leading cause of cancer-related death in the United States and there is still a lack of effective treatments to improve patient survival rate. Hence, the purpose of the present retrospective study was to assess the potential clinical impact of repeated