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Therapeutic Effects of Lifei Decoction in a Murine Model of COPD Induced by LPS and Cigarette Smoke Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-04-18 Liguo Lu, Chengdong Zhu, Jian Xu, Yulan Hu, Juxiang Dai, Sheng Wang, Tao Wei
Introduction: The Lifei Decoction (LD) is a commonly utilized Chinese medicine for the treatment of sepsis and bronchial inflammation. However, its therapeutic potential in chronic obstructive pulmonary disease (COPD) remains unknown. Therefore, the objective of this study was to investigate the therapeutic efficacy and underlying mechanism of LD in a mouse model of COPD induced by cigarette smoke
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Characteristics of Users and New Initiators of Single- and Multiple-Inhaler Triple Therapy for Chronic Obstructive Pulmonary Disease in Germany Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-04-17 Kai-Michael Beeh, Kieran J Rothnie, Jing Claussen, Fränce Hardtstock, Rachel K Knapp, Thomas Wilke, Alexandrosz Czira, Chris Compton, Afisi S Ismaila
Purpose: To assess patient characteristics of users and new initiators of triple therapy for chronic obstructive pulmonary disease (COPD) in Germany. Patients and Methods: Retrospective cohort study of patients with COPD and ≥ 1 prescription for single-inhaler triple therapy (SITT; fluticasone furoate/umeclidinium/vilanterol [FF/UMEC/VI] or beclomethasone dipropionate/glycopyrronium bromide/formoterol
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Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR) and Monocyte-to-Lymphocyte Ratio (MLR) as Biomarkers in Diagnosis Evaluation of Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective, Observational Study Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-04-15 Chuang Cai, Wentan Zeng, Hongwei Wang, Shuqi Ren
Purpose: Hierarchical management is advocated in China to effectively manage chronic obstructive pulmonary disease (COPD) patients and reduce the incidence and mortality of acute exacerbation of COPD (AE-COPD). However, primary and community hospitals often have limited access to advanced equipment and technology. Complete blood count (CBC), which is commonly used in these hospitals, offers the advantages
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Correlation Between HIF1-A Expression and Airway Remodeling in COPD Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-04-13 Lingfang Tan, Xuefeng Yang, Jianxin Zhang, Kebing Zhou
Background: Airway remodeling is a significant pathological characteristic of chronic obstructive pulmonary disease (COPD). In recent years, hypoxia-inducible factor 1-α (HIF-1α), a member of the hypoxia-inducible factor protein family, has gained attention. However, the potential correlation between HIF-1α and COPD airway remodeling remains unclear. Objective: This study explored the expression patterns
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Association of Frailty with Patient-Report Outcomes and Major Clinical Determinants in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-04-12 Mengjiao Yang, Yang Liu, Yangyang Zhao, Ziwei Wang, Jie He, Yali Wang, Tokie Anme
Purpose: This study aimed to explore the correlation of frailty status with disease characteristics and patient-reported outcomes (PROs) in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and determine the sensitivity and specificity of modified COPD PRO scale (mCOPD-PRO) for detecting frailty. Patients and Methods: This cross-sectional study surveyed 315 inpatients
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Neutrophil/Lymphocyte Ratio as a Predictive Biomarker of NIV Failure in AECOPD: The Unveiled Facts [Letter] Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-04-11 Dipasri Bhattacharya, Antonio M Esquinas, Mohanchandra Mandal
Letter for the article The Neutrophil/Lymphocyte Ratio Could Predict Noninvasive Mechanical Ventilation Failure in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Retrospective Observational Study
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Prevalence and Risk Factors of Chronic Obstructive Pulmonary Disease Among Users of Primary Health Care Facilities in Morocco [Letter] Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-04-10 Song Wang, Jing Song, Xiaolian Jiang
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Long-Term SGRQ Stability in a Cohort of Individuals with Alpha-1 Antitrypsin Deficiency-Associated Lung Disease Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-04-10 Radmila Choate, Kristen E Holm, Robert A Sandhaus, David M Mannino, Charlie Strange
Background: Health-related quality of life (HRQoL) assessments such as St. George’s Respiratory Questionnaire (SGRQ) are often used as outcome measures to evaluate patient-perceived changes in health status among individuals with lung disease. Several factors have been linked to deterioration in SGRQ, including symptoms (dyspnea, wheezing) and exercise intolerance. Whether these findings apply to individuals
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Prevalence and Associated Factors of Chronic Obstructive Pulmonary Disease among Adults in Neno District, Malawi: A Cross-Sectional Analytical Study [Response To Letter] Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-04-06 Haules Robbins Zaniku, Emilia Connolly, Moses Banda Aron, Beatrice Lydia Matanje, Myness Kasanda Ndambo, George Complex Talama, Fabien Munyaneza, Todd Ruderman, Jamie Rylance, Luckson Wandani Dullie, Rejani Lalitha, Ndaziona Peter Kwanjo Banda, Adamson S Muula
Response to Letter in regards to Prevalence and Associated Factors of Chronic Obstructive Pulmonary Disease Among Adults in Neno District, Malawi: A Cross-Sectional Analytical Study [Letter]
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Promising Intestinal Microbiota Associated with Clinical Characteristics of COPD Through Integrated Bioinformatics Analysis Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-04-05 Tianwen Lai, Chaole Luo, Yalian Yuan, Jia Fang, Yun Wang, Xiantong Tang, Lihuan Ouyang, Keyan Lin, Bin Wu, Weimin Yao, Ruina Huang
Introduction: Chronic obstructive pulmonary disease (COPD), an incurable chronic respiratory disease, has become a major public health problem. The relationship between the composition of intestinal microbiota and the important clinical factors affecting COPD remains unclear. This study aimed to identify specific intestinal microbiota with high clinical diagnostic value for COPD. Methods: The fecal
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Multidimensional Frailty Instruments Can Predict Acute Exacerbations Within One Year in Patients with Stable Chronic Obstructive Pulmonary Disease: A Retrospective Longitudinal Study Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-04-04 Lujie Wei, Pingyang Li, Xiaofeng Liu, Yuxia Wang, Zhengping Tang, Hang Zhao, Lu Yu, Kaixiu Li, Jianping Li, Min Du, Xinzhu Chen, Xin Zheng, Yixiong Zheng, Yao Luo, Jing Chen, Xiamin Jiang, Xiaobing Chen, Huaicong Long
Background: Chronic obstructive pulmonary disease (COPD) is closely associated with frailty, and prevention of acute exacerbations is important for disease management. Moreover, COPD patients with frailty experience a higher risk of acute exacerbations. However, the frailty instruments that can better predict acute exacerbations remain unclear. Purpose: (1) To explore the factors influencing frailty
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Can the ADO Index Be Used as a Predictor of Mortality from COVID-19 in Patients with COPD? Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-04-04 Esra Ertan Yazar, Gulsah Gunluoglu, Burcu Arpinar Yigitbas, Mukadder Calikoglu, Gazi Gulbas, Nilgün Yılmaz Demirci, Nurhan Sarioglu, Fulsen Bozkus, Nevin Taci Hoca, Nalan Ogan, Seda Tural Onur, Muzaffer Onur Turan, Filiz Kosar, Evrim Eylem Akpinar, Burak Mete, Can Ozturk
Background: Several studies have shown that the risk of mortality due to COVID-19 is high in patients with COPD. However, evidence on factors predicting mortality is limited. Research Question: Are there any useful markers to predict mortality in COVID-19 patients with COPD?. Study Design and Methods: A total of 689 patients were included in this study from the COPET study, a national multicenter observational
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Use of Ecological Momentary Assessment to Measure Dyspnea in COPD Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-28 Sarah N Miller, Michelle Nichols, Ronald J Teufel II, Erin P Silverman, Marta Walentynowicz
Abstract: Dyspnea is an unpredictable and distressing symptom of chronic obstructive pulmonary disease (COPD). Dyspnea is challenging to measure due to the heterogeneity of COPD and recall bias associated with retrospective reports. Ecological Momentary Assessment (EMA) is a technique used to collect symptoms in real-time within a natural environment, useful for monitoring symptom trends and risks
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Comparison of the Application of Vibrating Mesh Nebulizer and Jet Nebulizer in Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta‐analysis Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-28 Zhouzhou Feng, Zhengcai Han, Yaqin Wang, Hong Guo, Jian Liu
Objective: To comparison of the application of Vibrating Mesh Nebulizer and Jet Nebulizer in chronic obstructive pulmonary disease (COPD). Research Methods: This systematic review and meta-analysis was conducted following the Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) statements. The primary outcome measures analyzed included: The amount of inhaler in the urine sample
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Silencing KLF6 Alleviates Cigarette Smoke Extract-Induced Mitochondrial Dysfunction in Bronchial Epithelial Cells by SIRT4 Upregulation Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-23 Menghong Wan, Chen Wang, Jiamin Cui, Qing Xia, Lei Zhang
Background: The incidence of chronic obstructive pulmonary disease (COPD) is increasing year by year. Kruppel-like factor 6 (KLF6) plays an important role in inflammatory diseases. However, the regulatory role of KLF6 in COPD has not been reported so far. Methods: The viability of human bronchial epithelial cells BEAS-2B induced by cigarette smoke extract (CSE) was detected by CCK-8 assay. The protein
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Network Pharmacology and Experimental Verification Reveal the Regulatory Mechanism of Chuanbeimu in Treating Chronic Obstructive Pulmonary Disease Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-21 Meilan Xian, Jiaoyuan Xu, Yamei Zheng, Lei Zhang, Jie Zhao, Jie Chen, Siguang Li, Lingsang Lin, Yi Zhong, Zehua Yang, Tian Xie, Linhui Huang, Yipeng Ding
Background: Chronic obstructive pulmonary disease (COPD) is a common respiratory disorder in pulmonology. Chuanbeimu (CBM) is a traditional Chinese medicinal herb for treating COPD and has been widely utilized in clinical practice. However, the mechanism of CBM in the treatment of COPD remains incompletely understood. This study aims to investigate the underlying therapeutic mechanism of CBM for COPD
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Circular RNA Expression of Peripheral Blood Mononuclear Cells Associated with Risk of Acute Exacerbation in Smoking Chronic Obstructive Pulmonary Disease Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-20 Xu-Rui Shen, Ying-Ying Liu, Rui-Qi Qian, Wei-Yun Zhang, Jian-An Huang, Xiu-Qin Zhang, Da-Xiong Zeng
Purpose: Circular RNAs (circRNAs) are newly identified endogenous non-coding RNAs that function as crucial gene modulators in the development of several diseases. By assessing the expression levels of circRNAs in peripheral blood mononuclear cells (PBMCs) from patients with chronic obstructive pulmonary disease (COPD), this study attempted to find new biomarkers for COPD screening. Patients and Methods:
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Inhibitory Effect of P22077 on Airway Inflammation in Rats with COPD and Its Mechanism Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-20 Di Zeng, Wenbo Zhang, Xiaoju Chen, Guochun Ou, Yuewei Huang, Chengxiu Yu
Purpose: Here, we studied the pharmacological effect of P22077 on airway inflammation induced by lipopolysaccharide and cigarette smoke and explored the therapeutic mechanism of P22077 in COPD model RAT. Patients and Methods: The COPD model was established by lipopolysaccharide combined with fumigation; animals were treated with vehicle or P22077. Serum, bronchoalveolar lavage fluid (BALF), and lung
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A Cross-Sectional Study Evaluating the Association of Brachial Artery Flow Mediated Vasodilation with Physical Activity Measured by Accelerometry in Patients with the Overlap of Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-19 Madalina Macrea, Atul Malhotra, Richard ZuWallack, Krisann Oursler, Richard Casaburi
Abstract: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in Overlap Syndrome (OS), the co-occurrence of Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease. Clustering of patients in subgroups with similar pre-clinical manifestations (ie, endothelial dysfunction) may identify relevant therapeutic phenotype categories for patients with OS who are at high risk
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High Blood Eosinophil Count at Stable State is Not Associated with Airway Microbiota Distinct Profile in COPD Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-18 Jeanne-Marie Perotin, Anaëlle Muggeo, Quentin Lecomte-Thenot, Audrey Brisebarre, Sandra Dury, Claire Launois, Julien Ancel, Valérian Dormoy, Thomas Guillard, Gaëtan Deslee
Purpose: The heterogeneity of clinical features in COPD at stable state has been associated with airway microbiota. Blood eosinophil count (BEC) represents a biomarker for a pejorative evolution of COPD, including exacerbations and accelerated FEV1 decline. We aimed to analyse the associations between BEC and airway microbiota in COPD at stable state. Patients and Methods: Adult COPD patients at stable
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Preserved Ratio Impaired Spirometry (PRISm): A Global Epidemiological Overview, Radiographic Characteristics, Comorbid Associations, and Differentiation from Chronic Obstructive Pulmonary Disease Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-15 Jia Huang, Wenjun Li, Yecheng Sun, Zhutang Huang, Rong Cong, Chen Yu, Hongyan Tao
Abstract: Preserved Ratio Impaired Spirometry (PRISm) manifests notable epidemiological disparities across the globe, with its prevalence and influential factors showcasing pronounced diversities among various geographical territories and demographics. The prevalence of PRISm fluctuates considerably among regions such as Latin America, the United States, and Asian nations, potentially correlating with
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Severe COPD: Multidisciplinary Consultation to Get the Right Care at the Right Place Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-14 Pieter-Paul Hekking, Monique van Meggelen, W Johan Lie, Rogier Arnaud Sebastiaan Hoek, Dirk van Ranst, Stephan Cornelis Johan van der Kleij, Leonard Seghers, Jasper Kappen, Gert-Jan Braunstahl, Johannes In 't Veen
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Unveiling the Knowledge Frontier: A Scientometric Analysis of COPD with Sarcopenia Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-12 Jingfeng Zou, Wen Peng
Objective: Numerous articles and reviews addressing the intersection of Chronic Obstructive Pulmonary Disease (COPD) with sarcopenia have been documented. However, a significant gap exists in the literature concerning scientometric analysis in this field. This study aimed to concentrate on recent research and elucidate emerging research areas through the examination of COPD with sarcopenia. Methods:
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Automated Quantification of QT-Intervals by an Algorithm: A Validation Study in Patients with Chronic Obstructive Pulmonary Disease Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-12 Dario Kohlbrenner, Maya Bisang, Sayaka S Aeschbacher, Emanuel Heusser, Silvia Ulrich, Konrad E Bloch, Michael Furian
Study Objectives: To assess the diagnostic accuracy of a purpose-designed QTc-scoring algorithm versus the established hand-scoring in patients with chronic obstructive pulmonary disease (COPD) undergoing sleep studies. Methods: We collected 62 overnight electrocardiogram (ECG) recordings in 28 COPD patients. QT-intervals corrected for heart rate (QTc, Bazett) were averaged over 1-min periods and quantified
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Efficacy of Acupuncture in Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-11 Chunyan Yang, Hao Tian, Guixing Xu, Qin Luo, Mingsheng Sun, Fanrong Liang
Purpose: The effect of acupuncture as adjunctive therapy for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) was controversial. Thus, we aimed to evaluate the effects of acupuncture for treating AECOPD. Methods: Eight databases were searched from database inception to July 30, 2023. All RCTs compared acupuncture plus conventional western medicine with conventional western medicine
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The Changing and Predicted Trends in Chronic Obstructive Pulmonary Disease Burden in China, the United States, and India from 1990 to 2030 Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-08 Baojun Guo, Hui Gan, Mingshan Xue, Zhifeng Huang, Zhiwei Lin, Shiyun Li, Peiyan Zheng, Baoqing Sun
Background: This study analyzed the burden of chronic obstructive pulmonary disease (COPD) in China, the United States, and India from 1990 to 2019 and projected the trends for the next decade. Methods: This study utilized the GBD 2019 to compare the age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), age-standardized disability-adjusted life years (DALYs) rate, and the
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Acute Exacerbation of Chronic Obstructive Pulmonary Disease Due to Carbapenem-Resistant Klebsiella pneumoniae-Induced Pneumonia: Clinical Features and Prognostic Factors Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-07 Pengwen Ouyang, Zhijie Zhou, Chanyuan Pan, Peijuan Tang, Sheng Long, Xiangjian Liao, Qiong Liu, Liangyi Xie
Purpose: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is closely related to respiratory tract infection. The aim of this study was to investigate the clinical features and prognostic factors of CRKP-induced pneumonia in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients. Methods: A single-centre, retrospective case-control study on COPD patients hospitalized for acute
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Respiratory Oscillometry and Functional Performance in Different COPD Phenotypes Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-06 Elayne Moura Teixeira, Caroline Oliveira Ribeiro, Agnaldo José Lopes, Pedro Lopes de Melo
Purpose: Chronic obstructive pulmonary disease (COPD) phenotypes may introduce different characteristics that need to be known to improve treatment. Respiratory oscillometry provides a detailed analysis and may offer insight into the pathophysiology of COPD. In this paper, we used this method to evaluate the differences in respiratory mechanics of COPD phenotypes. Patients and Methods: This study investigated
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Prevalence and Associated Factors of Chronic Obstructive Pulmonary Disease Among Adults in Neno District, Malawi: A Cross-Sectional Analytical Study [Letter] Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-05 Elanda Fikri
Letter for the article Prevalence and Associated Factors of Chronic Obstructive Pulmonary Disease Among Adults in Neno District, Malawi: A Cross-Sectional Analytical Study
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The Dosing Strategy to Improve Adherence to Roflumilast in Treatment for Chronic Obstructive Lung Disease: A Systemic Review and Meta-Analysis Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-05 Jonghoo Lee, Jae-Uk Song
Background: The clinical efficacy of roflumilast, an oral phosphodiesterase-4 inhibitor, has been demonstrated in patients with severe chronic obstructive pulmonary disease (COPD). However, roflumilast has shown frequent adverse drug reactions (ADRs). This study was performed to investigate the dosing strategy that will improve adherence to roflumilast in COPD. Methods: We conducted a systematic review
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Genetic Insights into the Gut-Lung Axis: Mendelian Randomization Analysis on Gut Microbiota, Lung Function, and COPD Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-04 Zi-Xuan Cheng, Jian-Lan Hua, Zhi-Jun Jie, Xing-Jing Li, Jing Zhang
Background: Chronic obstructive pulmonary disease (COPD) is a respiratory disorder with a complex etiology involving genetic and environmental factors. The dysbiosis of gut microbiota has been implicated in COPD. Mendelian Randomization (MR) provides a tool to investigate causal links using genetic variants as instrumental variables. This study aims to employ MR analysis to explore the causal relationship
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Common Pathogeneses Underlying Asthma and Chronic Obstructive Pulmonary Disease -Insights from Genetic Studies Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-04 Nobuyuki Hizawa
Abstract: Neither asthma nor chronic obstructive pulmonary disease (COPD) is a single disease consisting of a uniform pathogenesis; rather, they are both syndromes that result from a variety of basic distinct pathogeneses. Many of the basic pathogeneses overlap between the two diseases, and multiple basic pathogeneses are simultaneously involved at varying proportions in individual patients. The specific
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Prognostic Value of Leukocyte-Based Risk Model for Acute Kidney Injury Prediction in Critically Ill Acute Exacerbation of Chronic Obstructive Pulmonary Disease Patients Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-04 Min Cai, Yue Deng, Tianyang Hu
Purpose: Acute kidney injury (AKI) is a common complication of acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and inflammation is the potential link between AKI and AECOPD. However, little is known about the incidence and risk stratification of AKI in critically ill AECOPD patients. In this study, we aimed to establish risk model based on white blood cell (WBC)-related indicators
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Exacerbation Burden in COPD and Occurrence of Mortality in a Cohort of Italian Patients: Results of the Gulp Study Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-03-01 Pierachille Santus, Fabiano Di Marco, Fulvio Braido, Marco Contoli, Angelo Guido Corsico, Claudio Micheletto, Girolamo Pelaia, Dejan Radovanovic, Paola Rogliani, Laura Saderi, Nicola Scichilone, Silvia Tanzi, Manlio Vella, Silvia Boarino, Giovanni Sotgiu, Paolo Solidoro
Objective: To describe the burden of moderate to severe exacerbations and all-cause mortality; the secondary objectives were to analyze treatment patterns and changes over follow-up. Design: Observational, multicenter, retrospective, cohort study with a three year follow-up period. Setting: Ten Italian academic secondary- and tertiary-care centers. Participants: Patients with a confirmed diagnosis
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Analysis of Key Genes and miRNA-mRNA Networks Associated with Glucocorticoids Treatment in Chronic Obstructive Pulmonary Disease Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-28 Jian-Jun Wu, Ping-An Zhang, Ming-Zhe Chen, Yi Zhang, Wei-Sha Du, Xiao-Ning Li, Guo-Chao Ji, Liang-Duo Jiang, Yang Jiao, Xin Li
Background: Some patients with chronic obstructive pulmonary disease (COPD) benefit from glucocorticoid (GC) treatment, but its mechanism is unclear. Objective: With the help of the Gene Expression Omnibus (GEO) database, the key genes and miRNA-mRNA related to the treatment of COPD by GCs were discussed, and the potential mechanism was explained. Methods: The miRNA microarray dataset (GSE76774) and
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Association Between Serum Anion Gap and Mortality in Critically Ill Patients with COPD in ICU: Data from the MIMIC IV Database Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-29 Xiaojing Chen, Qilin Yang, Li Gao, Weinan Chen, Xiaoyu Gao, Yameng Li, Liying Ao, Dejun Sun
Background: Serum anion gap (AG) has been proven to be associated with prognosis in critically ill patients. However, few studies have investigated the association between AG and all-cause mortality in critically ill patients with chronic obstructive pulmonary disease (COPD). Objective: We hypothesized that the initial AG level would predict the mortality risk in critically ill patients with COPD.
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Extrapulmonary Comorbidities Associated with Chronic Obstructive Pulmonary Disease: A Review Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-29 Yurong Xiang, Xiaobin Luo
Abstract: Most patients with chronic obstructive pulmonary disease (COPD) suffer from at least one additional, clinically relevant chronic disease. To a degree, the high global prevalence and mortality rate of COPD is closely related to its extrapulmonary effects. Moreover, the various of comorbidities of COPD and itself interact with each other, resulting in diverse clinical manifestations and individual
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Respiratory Infection Triggering Severe Acute Exacerbations of Chronic Obstructive Pulmonary Disease Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-27 Georges Abi Abdallah, Sylvain Diop, Matthieu Jamme, Stéphane Legriel, Alexis Ferré
Background: Data are scarce on respiratory infections during severe acute exacerbation of chronic obstructive pulmonary disease (COPD). This study aimed to investigate respiratory infection patterns in the intensive care unit (ICU) and identify variables associated with infection type and patient outcome. Methods: A retrospective, single-centre cohort study. All patients admitted (2015– 2021) to our
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Association Between Serum Klotho and Chronic Obstructive Pulmonary Disease in US Middle-Aged and Older Individuals: A Cross-Sectional Study from NHANES 2013–2016 Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-26 Yushan Shi, Zhangmeng Xu, Shuangshuang Pu, Kanghong Xu, Yanan Wang, Chunlai Zhang
Purpose: This study sought to examine the potential association between serum Klotho levels and the prevalence of COPD in the United States. Patients and Methods: This study was a cross-sectional analysis involving 4361 adults aged 40– 79 years participating in the US National Health and Nutrition Examination Survey (NHANES) conducted between 2013 and 2016. Our investigation utilized multivariate logistic
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Lack of Evidence Regarding Markers Identifying Acute Heart Failure in Patients with COPD: An AI-Supported Systematic Review Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-23 Sanne HB van Dijk, Marjolein GJ Brusse-Keizer, Charlotte C Bucsán, Eline H Ploumen, Wendy JC van Beurden, Job van der Palen, Carine JM Doggen, Anke Lenferink
Background: Due to shared symptoms, acute heart failure (AHF) is difficult to differentiate from an acute exacerbation of COPD (AECOPD). This systematic review aimed to identify markers that can diagnose AHF underlying acute dyspnea in patients with COPD presenting at the hospital. Methods: All types of observational studies and clinical trials that investigated any marker’s ability to diagnose AHF
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Acute Exacerbation and Longitudinal Lung Function Change of Preserved Ratio Impaired Spirometry Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-23 Si Mong Yoon, Kwang Nam Jin, Hyo Jin Lee, Hyun Woo Lee, Tae Yun Park, Eun Young Heo, Deog Kyeom Kim, Jung-Kyu Lee
Background: Preserved ratio impaired spirometry (PRISm) is a heterogeneous disease entity. Limited data are available regarding its prevalence, clinical course, or prognosis. We aimed to evaluate the longitudinal clinical course of patients with PRISm compared with chronic obstructive pulmonary disease (COPD). Methods: A retrospective study enrolled PRISm and COPD patients who underwent chest computed
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Platelet-to-Lymphocyte Ratio (PLR), Neutrophil-to-Lymphocyte Ratio (NLR), Monocyte-to-Lymphocyte Ratio (MLR), and Eosinophil-to-Lymphocyte Ratio (ELR) as Biomarkers in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-23 Qian-Qian Liao, Yan-Ju Mo, Ke-Wei Zhu, Feng Gao, Bin Huang, Peng Chen, Feng-Tian Jing, Xuan Jiang, Hong-Zhen Xu, Yan-Feng Tang, Li-Wei Chu, Hai-Ling Huang, Wen-Li Wang, Fang-Ning Wei, Dan-Dan Huang, Bin-Jing Zhao, Jia Chen, Hao Zhang
Purpose: The study comprehensively evaluated the prognostic roles of the platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), basophil-to-lymphocyte ratio (BLR), and eosinophil-to-lymphocyte ratio (ELR) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Patients and Methods: Six hundred and nineteen patients
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GSTP1 rs4147581 C>G and NLRP3 rs3806265 T>C as Risk Factors for Chronic Obstructive Pulmonary Disease: A Case-Control Study Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-22 Honge Li, Raorao Wang, Xueyan Wei, Chunyan Zhang, Wenhui Pei, Xuhui Zhang, Zhen Yang, Zhi Li, Yuhuan Zhang, Yanli Shi, Yunchao Wang, Xinhua Wang
Background: Chronic obstructive pulmonary disease (COPD) is a chronic respiratory ailment influenced by a blend of genetic and environmental factors. Inflammatory response and an imbalance in oxidative-antioxidant mechanisms constitute the primary pathogenesis of COPD. Glutathione S-transferase P1(GSTP1) plays a pivotal role as an antioxidant enzyme in regulating oxidative-antioxidant responses in
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TRITRIAL: The Impact of Fixed Triple Therapy with Beclometasone/Formoterol/Glycopyrronium on Health Status and Adherence in Chronic Obstructive Pulmonary Disease in an Italian Context of Real Life Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-23 Luca Richeldi, Pietro Schino, Elena Bargagli, Alberto Ricci, Alberto Rocca, Francesca Marchesani, Alfio Pennisi, Gianna Camiciottoli, Maria D'Amato, Francesco Macagno, Ulrica Scaffidi Argentina, Eleonora Ingrassia, Alessio Piraino
Purpose: The TRITRIAL study assessed the effects of beclometasone dipropionate/formoterol fumarate/glycopyrronium (BDP/FF/G) fixed combination in patients with chronic obstructive pulmonary disease (COPD) in a real-world setting, focusing on patient’s experience and perspective through the use of patients reported outcomes. Patients and Methods: TRITRIAL was a multicenter, prospective, observational
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Relationship Between Systemic Immune-Inflammation Index and Risk of Respiratory Failure and Death in COPD: A Retrospective Cohort Study Based on the MIMIC-IV Database Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-19 Ye Zhang, Xiaoli Tan, Shiyu Hu, Zhifang Cui, Wenyu Chen
Purpose: Chronic obstructive pulmonary disease (COPD) concurrent with respiratory failure (RF) is devastating, and may result in death and disability. Systemic immune-inflammation index (SII) is a new prognostic biomarker linked to unfavorable outcomes of acute coronary syndrome, ischemic stroke, and heart failure. Nonetheless, its role in COPD is rarely investigated. Consequently, this study intends
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Case-Finding and Treatment Effects in COPD: Secondary Analysis of an Interdisciplinary Intervention Trial Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-14 Kate Petrie, Michael J Abramson, Johnson George
Background: US Preventive Services Taskforce recommends against screening for COPD in asymptomatic adults due to limited evidence on the efficacy of treatments for this population. However, global and Australian guidelines recommend a case-finding approach where those with symptoms and/or risk factors, including smoking, are screened. This study aims to explore patient characteristics by time of COPD
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Inpatient Admissions and Re-Admissions in Medicare Beneficiaries Initiating Umeclidinium/Vilanterol or Tiotropium Therapy Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-13 Michael Bogart, Gary Yat-Hung Leung, Anissa Cyhaniuk, Kristi DiRocco
Purpose: Patients with chronic obstructive pulmonary disease (COPD) who are hospitalized are more likely to die from their illness and have increased likelihood of re-admission than those who are not. Subsequent re-admissions further increase the burden on healthcare systems. This study compared inpatient admission rates and time-to-first COPD-related inpatient admission among Medicare beneficiaries
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Glucocorticoid Use in Patients Hospitalized with Chronic Obstructive Pulmonary Disease Exacerbations Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-12 Songsong Yu, Shuang Li, Jie Zhang, Qiuhong Fang
Objective of the Study: Systemic glucocorticoid therapy can improve the outcomes of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The study tried to investigate the use of glucocorticoids in AECOPD patients and the factors associated with the physicians’ choice. Methodology: Patients with AECOPD over two periods were divided by the year of 2017 when GOLD and ERS/ATS Guideline
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Identification and Characterization of a ceRNA Regulatory Network Involving LINC00482 and PRRC2B in Peripheral Blood Mononuclear Cells: Implications for COPD Pathogenesis and Diagnosis Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-08 Wenjie Huang, Ting Luo, Mengqiu Lan, Wenting Zhou, Ming Zhang, Lihong Wu, Zhenni Lu, Li Fan
Purpose: Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide, characterized by intense lung infiltrations of immune cells (macrophages and monocytes). While existing studies have highlighted the crucial role of the competitive endogenous RNA (ceRNA) regulatory network in COPD development, the complexity and characteristics of the ceRNA network in monocytes remain
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Lianhua Qingke Preserves Mucociliary Clearance in Rat with Acute Exacerbation of Chronic Obstructive Pulmonary Disease by Maintaining Ciliated Cells Proportion and Protecting Structural Integrity and Beat Function of Cilia Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-07 Xiaoqi Wang, Yuanjie Hao, Yujie Yin, Yunlong Hou, Ningxin Han, Yi Liu, Zhen Li, Yaru Wei, Kun Ma, Jiaojiao Gu, Yan Ma, Hui Qi, Zhenhua Jia
Purpose: Acute Exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) is a sudden worsening of symptoms in patients with Chronic Obstructive Pulmonary Disease (COPD), such as cough, increased sputum volume, and sputum purulence. COPD and AECOPD are characterized by damage to cilia and increased mucus secretion. Mucociliary clearance (MCC) functions as part of the primary innate system of the
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Prevalence and Associated Factors of Chronic Obstructive Pulmonary Disease Among Adults in Neno District, Malawi: A Cross-Sectional Analytical Study Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-05 Haules Robbins Zaniku, Emilia Connolly, Moses Banda Aron, Beatrice Lydia Matanje, Myness Kasanda Ndambo, George Complex Talama, Fabien Munyaneza, Todd Ruderman, Jamie Rylance, Luckson Wandani Dullie, Rejani Lalitha, Ndaziona Peter Kwanjo Banda, Adamson S Muula
Introduction: Chronic obstructive pulmonary disease (COPD) continues to pose a global public health challenge. However, literature is scarce on the burden of COPD in Malawi. We assessed the prevalence and risk factors for COPD among adults in Neno, Malawi. Methodology: We conducted a population-based analytical cross-sectional study in Neno District between December 2021 and November 2022. Using a
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Prevalence and Risk Factors of Chronic Obstructive Pulmonary Disease Among Users of Primary Health Care Facilities in Morocco Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-05 Nadia Al wachami, Maryem Arraji, Younes Iderdar, Yassmine Mourajid, Karima Boumendil, Fatima Zahra Bouchachi, Samira Jaouhar, Morad Guennouni, Fatimazahra Laamiri, Noureddine Elkhoudri, Lahcen Bandadi, Mohamed Lahbib Louerdi, Abderraouf Hilali, Mohamed Chahboune
Background: Chronic obstructive pulmonary disease (COPD) is a major public health problem. In Morocco, few studies have focused on COPD in primary health care facilities, whose main mission is prevention. The aim of our work is thus to assess the prevalence of COPD and to study the factors associated with this silent disease among users of health care facilities in Morocco. Methods: This is a cross-sectional
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Circular RNA_0025843 Alleviated Cigarette Smoke Extract Induced Bronchoalveolar Epithelial Cells Ferroptosis Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-03 Jia Chen, Xiaoyu Deng, Hansheng Xie, Caiyun Wang, Jiefeng Huang, Ningfang Lian
Purpose: Circular RNA (circRNA) plays an important role in various biological processes. However, their functions in cigarette smoke extract (CSE) induced human normal lung epithelial cells (BEAS-2B) injury remain vague. The study aimed to explore circRNA expression profiles and reveal their potential roles in CSE-treated BEAS-2B cells. Methods: 5% CSE exposure for 24 hours were used to build the BEAS-2B
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Alpha-1 Antitrypsin Gene Variants in Patients without Severe Deficiency Diagnosed with Pulmonary Emphysema on Chest CT Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-03 Eduardo Laviña, Sara Lumbreras, Lara Bravo, Joan B Soriano, José Luis Izquierdo, Jose Miguel Rodríguez
Introduction: Although pulmonary involvement due to alpha-1 antitrypsin (AAT) deficiency has been widely described, most studies focus on the genotypes causing severe deficiency (< 60 mg/dL). Objective: The aim of this study was to analyze the prevalence of the different AAT gene variants that do not cause severe deficiency in patients with pulmonary emphysema diagnosed by thoracic computed tomography
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Association of Chronic Obstructive Pulmonary Disease with Risk of Psychiatric Disorders: A Two-Sample Mendelian Randomization Study Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-01 Qinxia Zhang, Haifu Zhang, Qinxing Xu
Background: Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory disorder often accompanied by comorbidities. Although the past few years have witnessed significant scientific progress, the potential relationship between COPD and mental illness remains a subject of debate. Materials and Methods: We retrieved COPD data from the genome-wide association studies (GWAS) directory and
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Addressing Barriers to Chronic Obstructive Pulmonary Disease (COPD) Care: Three Innovative Evidence-Based Approaches: A Review Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-02-01 Damian Chi Hong Siu, Liat Gafni-Lachter
Abstract: Chronic obstructive pulmonary disease (COPD) is a preventable yet widespread and profoundly debilitating respiratory condition, exerting substantial personal and global health ramifications alongside significant economic implications. The first objective of this literature review was to identify reviews the barriers to optimal COPD care, categorizing them into personal patient factors, professional
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Lung Ultrasound Assessment of Lung Hyperinflation in Patients with Stable COPD: An Effective Diagnostic Tool Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-27 Yongjian Chen, Jingyun Li, Zhixing Zhu, Guorong Lyu
Purpose: To evaluate the degree of lung hyperinflation (LH) in patients with stable chronic obstructive pulmonary disease (COPD) by lung ultrasound score (LUS) and assess its value. Patients and Methods: We conducted a study of 149 patients with stable COPD and 100 healthy controls recruited by the Second Affiliated Hospital of Fujian Medical University. The pleural sliding displacement (PSD) was measured
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ApoA1, ApoB, ApoA1/B for Pathogenic Prediction of Chronic Obstructive Pulmonary Disease Complicated by Acute Lower Respiratory Tract Infection: A Cross-Sectional Study Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-26 Jiaqi Meng, Weichang Yang, Ziyong Chen, Caixia Pei, Xinmin Peng, Can Li, Fengyuan Li
Purpose: To investigate the value of apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), and ApoA1/B ratio in pathogenic diagnosis of chronic obstructive pulmonary disease (COPD) complicated by acute lower respiratory tract infection, assisting comprehensive disease assessment. Patients and Methods: The study enrolled 171 COPD patients with acute lower respiratory tract infections, 35 COPD patients
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Exploring a Potential Causal Link Between Dietary Intake and Chronic Obstructive Pulmonary Disease: A Two-Sample Mendelian Randomization Study Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-26 Chenwei Zhang, Lu Yu, Tao Xiong, Yukai Zhang, Juan Liu, Jingfen Zhang, Peiyun He, Yujia Xi, Yi Jiang
Background: Chronic Obstructive Pulmonary Disease (COPD), the most prevalent chronic respiratory condition, significantly impairs patients’ quality of life. The pivotal element in disease management lies in prevention, underscoring the paramount importance of employing a scientific approach to investigate early prevention strategies for COPD. Methods: This study delved into the causal link between
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Real-World Disease Burden and Healthcare Resource Utilization Among Patients with COPD and Asthma Using Triple Therapy (FF/UMEC/VI) in the United States Int. J. Chronic Obstruct. Pulm. Dis. (IF 2.8) Pub Date : 2024-01-25 Emmeline Igboekwe, Sumit Verma, Rosirene Paczkowski
Purpose: Chronic obstructive pulmonary disease (COPD) and asthma are associated with chronic inflammation of the respiratory tract; despite some overlap of symptoms, they are considered separate disorders. Triple therapy is recommended for patients with COPD and asthma whose symptoms remain uncontrolled despite dual therapy. There are limited real-world studies evaluating outcomes among patients with