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Transient pulmonary and gastric bleeding after iopamidol administration in a patient with marginal zone lymphoma: a case report BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-22 Weixian Xu, Miaozhen Chen, Songtao Liu, Yi Su, Yunhai Zhang
Iopamidol is a non-ionic, water-soluble iodine contrast agent that is considered safe for intravenous or intra-arterial administration and is widely used both in the general population and in patients undergoing oncological treatment. While adverse reactions to iopamidol have been documented, to date, no pulmonary and gastric hemorrhages induced by iopamidol have been reported in oncology patients
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Association between high-flow nasal cannula use and mortality in patients with sepsis-induced acute lung injury: a retrospective propensity score-matched cohort study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-22 Lijun Song, Min Li, Tianlong Zhang, Lei Huang, Jianjun Ying, Lan Ying
High-flow nasal cannula (HFNC) has emerged as a promising noninvasive method for delivering oxygen to critically ill patients, particularly those with sepsis and acute lung injury. However, uncertainties persist regarding its therapeutic benefits in this specific patient population. This retrospective study utilized a propensity score-matched cohort from the Medical Information Mart in Intensive Care-IV
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Effects and long-term outcomes of endurance versus resistance training as an adjunct to standard medication in patients with stable COPD: a multicenter randomized trial BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-22 Shilei Cui, Haiying Ji, Li Li, Huili Zhu, Xiangyang Li, Ying Gong, Yuanlin Song, Lijuan Hu, Xu Wu
Comparisons between endurance training (ET) and resistance training (RT) have produced equivocal findings in chronic obstructive pulmonary disease (COPD) patients. The purpose of our study is to investigate the effectiveness and long-term outcomes of adding ET and RT to conventional medical treatment in patients with COPD. A secondary objective is to investigate the clinical improvements resulting
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Abnormal expression of LCA and CD43 in SCLC: a rare case report and brief literature review BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-22 Zhe Cai, Linwei Zuo, Fangfang Hu, Huiyan You, Xiangtong Lu, Shousheng Liao, Fanrong Liu, Lixiang Li, Wenyong Huang
To present an unusual case of abnormal LCA expression and CD43 in SCLC and to review the reported literature to avoid potential diagnostic pitfalls. A 73-year-old male patient suffered from persistent back pain for more than one month. MRI revealed a compression fracture of the L1-L5 vertebra. A CT scan revealed multiple nodules and masses at the left root of the neck, lung hilum and mediastinum, and
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Unusual cause of muscle weakness, type II respiratory failure and pulmonary hypertension: a case report of ryanodine receptor type 1(RYR1)-related myopathy BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-22 Yinong Chen, Shuai Zhang, Xin Lu, Wanmu Xie, Chen Wang, Zhenguo Zhai
Patients with congenital myopathies may experience respiratory involvement, resulting in restrictive ventilatory dysfunction and respiratory failure. Pulmonary hypertension (PH) associated with this condition has never been reported in congenital ryanodine receptor type 1(RYR1)-related myopathy. A 47-year-old woman was admitted with progressively exacerbated chest tightness and difficulty in neck flexion
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Lung cancer in older patients with granulomatosis with polyangiitis: a report of three cases BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-22 Malgorzata Potentas-Policewicz, Malgorzata Szolkowska, Katarzyna Blasinska, Dariusz Gawryluk, Malgorzata Sobiecka, Justyna Fijolek
Granulomatosis with polyangiitis (GPA) is characterized by necrotizing granulomatous inflammation with necrotizing vasculitis predominantly affecting small to medium vessels. The survival rates have drastically improved; however, GPA can be lethal, with older patients having a worse prognosis and higher mortality than younger patients. Moreover, the incidence of various cancers has been reported to
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A pulmonary artery was embolized in a patient with an occluded pulmonary vein to manage massive hemoptysis BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-22 Dongping Xia, Wenhao Cao, Yi Hu
Stenosis and obliteration of the pulmonary vein can be developed by multiple diseases and might cause hemoptysis. Traditional therapy including surgical procedure and conservative treatments might be inappropriate choices to manage massive hemoptysis. A 64-year-old man, diagnosed with advanced stage IVA lung squamous cell carcinoma, presented with dyspnea and recurrent, massive hemoptysis. An initial
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Incidence and characteristics of aspiration pneumonia in the Nagasaki Prefecture from 2005 to 2019 BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-20 Iku Tomonaga, Hironobu Koseki, Chieko Imai, Takayuki Shida, Yuta Nishiyama, Daisuke Yoshida, Seiichi Yokoo, Makoto Osaki
Aspiration pneumoniae remains a major health concern, particularly in the older population and has poor prognosis; however, the concept itself remains vague worldwide. This study aimed to determine the actual situation and characteristics of aspiration pneumonia from 2005 to 2019 in Nagasaki Prefecture, Japan. Cases of aspiration pneumonia that occurred in the Nagasaki Prefecture between 2005 and 2019
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The role of colchicine in the management of COVID-19: a Meta-analysis BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-20 Kholoud Elshiwy, Ghada Essam El-Din Amin, Mohamed Nazmy Farres, Rasha Samir, Mohamed Farouk Allam
The Coronavirus disease 2019 (COVID-19) pandemic has robustly affected the global healthcare and economic systems and it was caused by coronavirus-2 (SARS-CoV-2). The clinical presentation of the disease ranges from a flu-like illness to severe pneumonia and death. Till September 2022, the cumulative number of cases exceeded 600 million worldwide and deaths were more than 6 million. Colchicine is an
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Asthma medication adherence, control, and psychological symptoms: a cross-sectional study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-19 Abdullah A. Alqarni, Abdulelah M. Aldhahir, Rayan A. Siraj, Jaber S. Alqahtani, Dana A. Alghamdi, Sarah K. Alghamdi, Abeer A. Alamoudi, Majduleen A. Mohtaseb, Mansour Majrshi, Abdulkareem A. AlGarni, Omaima I. Badr, Hassan Alwafi
Nonadherence to therapies and psychological disorders are associated with poor asthma control. This study aims to assess the prevalence of anxiety and depressive symptoms, asthma control, and adherence to inhalers and to investigate whether there is an association of anxiety and depressive symptoms with adherence to inhalers and asthma control. We measured anxiety and depressive symptoms using the
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A first look at the reliability, validity and responsiveness of L-PF-35 dyspnea domain scores in fibrotic hypersensitivity pneumonitis BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-19 Jeffrey J. Swigris, Kerri Aronson, Evans R. Fernández Pérez
Dyspnea impairs quality of life (QOL) in patients with fibrotic hypersensitivity pneumonitis (FHP). The Living with Pulmonary Fibrosis questionnaire (L-PF) assesses symptoms, their impacts and PF-related QOL in patients with any form of PF. Its scores have not undergone validation analyses in an FHP cohort. We used data from the Pirfenidone in FHP trial to examine reliability, validity and responsiveness
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Use of serum KL-6 and chest radiographic severity grade to predict 28-day mortality in COVID-19 patients with pneumonia: a retrospective cohort study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-18 Jing Zou, Yiping Shi, Shan Xue, Handong Jiang
Coronavirus disease 2019 (COVID-19) has had a global social and economic impact. An easy assessment procedure to handily identify the mortality risk of inpatients is urgently needed in clinical practice. Therefore, the aim of this study was to develop a simple nomogram model to categorize patients who might have a poor short-term outcome. A retrospective cohort study of 189 COVID-19 patients was performed
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Muscle loss phenotype in COPD is associated with adverse outcomes in the UK Biobank BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-17 Amy H. Attaway, Rocio Lopez, Nicole Welch, Annette Bellar, Umur Hatipoğlu, Joe Zein, Marielle PKJ Engelen, Srinivasan Dasarathy
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disorder with systemic consequences that can cause a muscle loss phenotype (MLP), which is characterized by the loss of muscle mass, muscle strength, or loss of both muscle and fat mass. There are limited data comparing the individual traits of MLP with clinical outcomes in a large unbiased cohort of COPD patients. Our aim was to
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Causal impact of gut microbiota and associated metabolites on pulmonary arterial hypertension: a bidirectional Mendelian randomization study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-17 Xin Li, Jiang-Shan Tan, Jing Xu, Zhihui Zhao, Qing Zhao, Yi Zhang, Anqi Duan, Zhihua Huang, Sicheng Zhang, Luyang Gao, Yue Jin Yang, Tao Yang, Qi Jin, Qin Luo, Yanmin Yang, Zhihong Liu
Patients with pulmonary arterial hypertension (PAH) exhibit a distinct gut microbiota profile; however, the causal association between gut microbiota, associated metabolites, and PAH remains elusive. We aimed to investigate this causal association and to explore whether dietary patterns play a role in its regulation. Summary statistics of gut microbiota, associated metabolites, diet, and PAH were obtained
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A prospective study on direct out-of-pocket expenses of hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease in a Philippine tertiary care center BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-17 Blake Warren Ang, Lenora Fernandez
Chronic obstructive pulmonary disease (COPD) is a frequent cause of morbidity and mortality in the Philippines and majority of the economic burden lies in hospitalizations during an exacerbation. Despite coverage of hospitalization cost with the national health insurance system (Phil-Health) for COPD exacerbations, patients often pay out-of-pocket. This study aimed to determine the demographic characteristics
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Abnormal heart rate responses to exercise in non-severe COPD: relationship with pulmonary vascular volume and ventilatory efficiency BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-17 Minghui Shi, Shiwei Qumu, Siyuan Wang, Yaodie Peng, Lulu Yang, Ke Huang, Ruoxi He, Feng Dong, Hongtao Niu, Ting Yang, Chen Wang
Despite being a prognostic predictor, cardiac autonomic dysfunction (AD) has not been well investigated in chronic obstructive pulmonary disease (COPD). We aimed to characterise computed tomography (CT), spirometry, and cardiopulmonary exercise test (CPET) features of COPD patients with cardiac AD and the association of AD with CT-derived vascular and CPET-derived ventilatory efficiency metrics. This
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Etiology of bacterial pneumonia and multi-drug resistance pattern among pneumonia suspected patients in Ethiopia: a systematic review and meta-analysis BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-16 Mihret Tilahun, Melaku Ashagrie Belete, Alemu Gedefie, Habtu Debash, Ermiyas Alemayehu, Daniel Gebretsadik, Hussein Ebrahim, Ousman Mohammed
Bacterial pneumonia can affect all age groups, but people with weakened immune systems, young children, and the elderly are at a higher risk. Streptococcus pneumoniae, Klebsiella pneumoniae, Haemophilus influenzae, and Pseudomonas aeruginosa are the most common causative agents of pneumonia, and they have developed high MDR in recent decades in Ethiopia. This systematic review and meta-analysis aimed
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Adenocarcinoma originating in the anterior mediastinum diagnosed by endobronchial ultrasound-guided transbronchial cryobiopsy: a case report BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-16 Hiroyuki Tsuchida, Yuji Matsumoto, Hideaki Furuse, Takaaki Tsuchida
Endobronchial ultrasound-guided transbronchial cryobiopsy (EBUS-cryobiopsy) is advantageous for collecting larger specimens with minimal crushing; however, it has not been widely used for mediastinal tumors. A 73-year-old woman with a history of left breast cancer underwent surgery followed by radiotherapy. Computed tomography showed a mass in the anterior mediastinum that was in extensive contact
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The association between frailty and survival in patients with pleural disease: a retrospective cohort study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-16 Eleanor Barton, A. Verduri, B. Carter, J. Hughes, J. Hewitt, N. A. Maskell
There are currently no data on the relationship between frailty and mortality in pleural disease. Understanding the relationship between frailty and outcomes is increasingly important for clinicians to guide decisions regarding investigation and management. This study aims to explore the relationship between all-cause mortality and frailty status in patients with pleural disease. In this retrospective
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Anti-synthase syndrome associated with SARS-Cov-2 infection BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-15 Xing-Yue Chen, Jun Chen, Li-Jia Zhi, Kun-Lan Long, Pei-Yang Gao
Anti-synthetase syndrome (AS) is a rare autoimmune idiopathic inflammatory myopathy (IIM) with diverse manifestations, including arthritis, interstitial lung disease (ILD), Raynaud’s phenomenon, unexplained persistent fever, and mechanic’s hands. We present the case of a 72-year-old woman, previously healthy, who was admitted to our hospital for treatment of cough and rapid breathing. The patient had
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The Fractional exhaled Nitric Oxide (FeNO)- test as add-on test in the diagnostic work-up of asthma: a study protocol BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-15 T. (Tuba) Kaya, G.J. (Gert-Jan) Braunstahl, J.C.C.M. (Johannes) in ’t Veen, J.H. (Jasper) Kappen, J.P.M. (Hanna) van der Valk
Asthma is a common disease characterized by chronic inflammation of the lower airways, bronchial hyperactivity, and (reversible) airway obstruction. The Global Initiative of Asthma Guideline recommends a flowchart to diagnose asthma with first-step spirometry with reversibility and a bronchial challenge test (BPT) with histamine or methacholine as a second step [1]. The BPT is considered burdensome
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Latent tuberculosis infection and infection-associated risk factors for miner workers with silicosis in eastern China BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-15 Xinsong Hu, Cheng Chen, Qianqian Gao, Lang Zhou, Yan Shao, Guoli Li, Honghuan Song, Qiao Liu, Lei Han, Limei Zhu
Silicosis people are at high risk of developing pulmonary tuberculosis. Whether silica exposure increases the likelihood of latent tuberculosis infection (LTBI) was not well understood, and potential factors involved in LTBI risk among silicosis people were not evaluated before. Thus, LTBI among silicosis people and potential risk factors for LTBI among silicosis people were evaluated in this study
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A prognostic model of idiopathic pulmonary fibrosis constructed based on macrophage and mitochondria-related genes BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-12 Yu Bao, Shiyuan Yang, Hailan Zhao, Yezhen Wang, Ke Li, Xue Liu, Wei Zhang, Xue Zhu
Studies have shown that mitochondrial function and macrophages may play a role in the development of idiopathic pulmonary fibrosis (IPF). However, the understanding of the interactions and specific mechanisms between mitochondrial function and macrophages in pulmonary fibrosis is still very limited. To construct a prognostic model for IPF based on Macrophage- related genes (MaRGs) and Mitochondria-related
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Lung adenocarcinoma discovered during the follow-up of lung-dominant connective tissue disease: a case report and literature review BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-12 Zi Heng Zhu, Yi Guo, Xiao Yin Wang, Xian Wen Sun
Interstitial lung disease (ILD) can lead to lung cancer, which brings great challenges to differential diagnosis and comprehensive treatment. However, the clinical features of lung-dominant connective tissue disease (LD-CTD) related ILD combined with lung cancer has not been validated. We report the case of an 80-year-old woman with LD-CTD treated regularly with nintedanib who presented progressive
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Impact of immune checkpoint inhibitors (ICIs) therapy on interferon-γ release assay (IGRA) and diagnostic value in non-small cell lung cancer (NSCLC) patients BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-12 Yijiao Xu, Qingwei Zhang, Zhisheng Chen, Shuwen Yang, Haiyan Chen, Xiong Xiao, Hongni Jiang
Tuberculosis (TB), a highly contagious respiratory disease, presents a significant global health threat, with a notable increase in incidence reported by the WHO in 2022. Particularly, the interplay between TB and non-small cell lung cancer (NSCLC) gains attention, especially considering the rising use of immune checkpoint inhibitors (ICIs) in cancer treatment. This interplay may influence TB diagnostics
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Extracellular vesicle dynamics in COPD: understanding the role of miR-422a, SPP1 and IL-17 A in smoking-related pathology BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-12 Zhihui Dai, Li Lin, Yanan Xu, Lifang Hu, Shiping Gou, Xinkai Xu
Chronic obstructive pulmonary disease (COPD) induced by smoking poses a significant global health challenge. Recent findings highlight the crucial role of extracellular vesicles (EVs) in mediating miRNA regulatory networks across various diseases. This study utilizes the GEO database to uncover distinct expression patterns of miRNAs and mRNAs, offering a comprehensive understanding of the pathogenesis
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Bronchiectasis-associated infections and outcomes in a large, geographically diverse electronic health record cohort in the United States BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-10 Samantha G Dean, Rebekah A Blakney, Emily E Ricotta, James D Chalmers, Sameer S Kadri, Kenneth N Olivier, D Rebecca Prevots
Bronchiectasis is a pulmonary disease characterized by irreversible dilation of the bronchi and recurring respiratory infections. Few studies have described the microbiology and prevalence of infections in large patient populations outside of specialized tertiary care centers. We used the Cerner HealthFacts Electronic Health Record database to characterize the nature, burden, and frequency of pulmonary
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Outcomes of coronary artery bypass grafting (CABG) in patients with OSA-COPD overlap syndrome versus COPD alone: an analysis of US Nationwide Inpatient Sample BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-08 Yen-Liang Yeh, Chien-Ming Lai, Hui-Pu Liu
Obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) are associated with unfavorable outcomes following coronary artery bypass grafting (CABG). The purpose of this study was to compare in-hospital outcomes of patients with COPD alone versus OSA-COPD overlap after CABG. Data of adults ≥ 18 years old with COPD who received elective CABG between 2005 and 2018 were extracted from
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A case of autoimmune pulmonary alveolar proteinosis during the course of treatment of rapidly progressive interstitial pneumonia associated with anti-MDA5 antibody-positive dermatomyositis BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-08 Masakiyo Yatomi, Keiichi Akasaka, Shintaro Sato, Mizuki Chida, Mio Kanbe, Hiru Sawada, Itaru Yokota, Ikuo Wakamatsu, Sohei Muto, Mari Sato, Kochi Yamaguchi, Yosuke Miura, Hiroaki Tsurumaki, Reiko Sakurai, Kenichiro Hara, Yasuhiko Koga, Noriaki Sunaga, Hideaki Yamakawa, Hidekazu Matsushima, Sahori Yamazaki, Yukie Endo, Sei-ichiro Motegi, Takeshi Hisada, Toshitaka Maeno
Autoimmune pulmonary alveolar proteinosis (APAP) is a diffuse lung disease that causes abnormal accumulation of lipoproteins in the alveoli; however, its pathogenesis remains unclear. Recently, APAP cases have been reported during the course of dermatomyositis. The combination of these two diseases may be coincidental; however, it may have been overlooked because differentiating APAP from a flare-up
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Physical activity and lung function association in a healthy community-dwelling European population BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-08 Sybile Collaud, Brice Touilloux, Christophe von Garnier, Pedro Marques-Vidal, Vanessa Kraege
The association of physical activity (PA) and lung function (LF) varies from no measurable effect to delayed LF decline. We assessed the association between accelerometery-assessed PA and LF in a sample of apparently healthy, community-dwelling subjects. We included two cross-sectional studies using data from the PneumoLaus study (2014–17 and 2018–21), conducted in Lausanne, Switzerland. PA was assessed
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Prior pneumococcal vaccination improves in-hospital mortality among elderly population hospitalized due to community-acquired pneumonia BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-08 Seohyun Kim, Moon Jin Kim, Jun-Pyo Myong, Yun-Hee Lee, Bo Yeon Kim, Ahyoung Hwang, Gui Ok Kim, Sung Hwan Jeong, Hyoung Kyu Yoon, Tai Joon An, Jeong Uk Lim
Pneumococcal vaccination is a preventive method to reduce pneumonia related mortality. However, real-world data on efficacy of the pneumococcal vaccine in reducing mortality is lacking, especially in elderly patients. This study was conducted to assess the effects of prior pneumococcal vaccination in elderly pneumonia patients. The data was procured from the Health Insurance Review and Assessment and
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Association of CCND1 rs9344 polymorphism with lung cancer susceptibility and clinical outcomes: a case-control study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-08 Chao Mei, Tian Wang, Baoli Xu, Sanlan Wu, Xuelin Zhang, Yongning Lv, Yu Zhang, Zhaoqian Liu, Weijing Gong
Cyclin D1 (CCND1) plays a pivotal role in cancer susceptibility and the platinum-based chemotherapy response. This study aims to assess the relationship between a common polymorphism (rs9344 G > A) in CCND1 gene with cancer susceptibility, platinum-based chemotherapy response, toxicities and prognosis of patients with lung cancer. This study involved 498 lung cancer patients and 213 healthy controls
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An immune-related adverse event of Behcet’s-like syndrome following pembrolizumab treatment BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-05 Qiao Chen, Deyu Li, Guifeng Zhang, Jiangming Zhong, Li Lin, Zhenhua Liu
In recent years, the emergence of immunotherapy has renewed therapeutic modality. Different from traditional anti-tumor therapy, immune-related adverse events of skin, gastrointestinal tract, liver, lung, endocrine glands commonly occurred. At present, only one case of immune-related adverse event of Behcet’s-like syndrome following pembrolizumab treatment was reported in USA, and no one is reported
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Effect of lung isolation with different airway devices on postoperative pneumonia in patients undergoing video-assisted thoracoscopic surgery: a propensity score-matched study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-04 Hongyi Xiao, Huan Zhang, Jiying Pan, Fangli Yue, Shuwen Zhang, Fanceng Ji
Postoperative pneumonia is one of the common complications after video-assisted thoracoscopic surgery. There is no related study on the effect of lung isolation with different airway devices on postoperative pneumonia. Therefore, in this study, the propensity score matching method was used to retrospectively explore the effects of different lung isolation methods on postoperative pneumonia in patients
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Patient experience with bronchoscopy: topical versus monitored anesthesia BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-04 Chun-Ta Huang, Rou-Jun Chou, Geng-Ning Hu, Tien-Cheng Lee, Yi-Ju Tsai, Chao-Chi Ho
This study aimed to compare patient experiences during bronchoscopy procedures using either topical anesthesia (TA) or monitored anesthesia care (MA). The goal was to identify circumstances where patients could achieve similar levels of tolerance and satisfaction using only TA, especially in resource-limited settings. This study included consecutive patients who underwent bronchoscopy with either TA
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Genetic association between smoking and DLCO in idiopathic pulmonary fibrosis patients BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-03 Ziheng Yuan, Wanyang Lei, Xiqian Xing, Xiaohua He, Xiaoxian Huang, Li Wei, Yuanyuan Lv, Shuyi Qiu, Ziyu Yuan, Jiyang Wang, Mei Yang
Observational studies have shown that smoking is related to the diffusing capacity of the lungs for carbon monoxide (DLCO) in individuals with idiopathic pulmonary fibrosis (IPF). Nevertheless, further investigation is needed to determine the causal effect between these two variables. Therefore, we conducted a study to investigate the causal relationship between smoking and DLCO in IPF patients using
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Endobronchial valves for emphysema and persistent air-leak: 10-year experience in an Asian country BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-03 Jin-Young Huh, Byeong-Ho Jeong, Ho il Yoon, Hojoong Kim, Young-Jae Cho, Changhwan Kim, Seung Jun Lee, Hwan hee Kim, Seung Won Ra, Ye Jin Lee, Beong Ki Kim, Sung Kyoung Kim, Ki Hyun Seo, Sei Won Lee
Endobronchial valve (EBV) therapy, a validated method for bronchoscopic lung volume reduction (BLVR) in severe emphysema, has been explored for persistent air-leak (PAL) management. However, its effectiveness and safety in the Asian population require further real-world evaluation. In this study, we assessed the outcomes of treatment with EBV within this demographic. We conducted a retrospective analysis
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Impact of recipient and donor pretransplantation body mass index on early postosperative complications after lung transplantation BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-03 E. Atchade, C. De Tymowski, E. Lepitre, N. Zappella, A. Snauwaert, S. Jean-Baptiste, A. Tran-Dinh, B. Lortat-Jacob, J. Messika, H. Mal, P. Mordant, Y. Castier, S. Tanaka, P. Montravers
Prior studies have assessed the impact of the pretransplantation recipient body mass index (BMI) on patient outcomes after lung transplantation (LT), but they have not specifically addressed early postoperative complications. Moreover, the impact of donor BMI on these complications has not been evaluated. The first aim of this study was to assess complications during hospitalization in the ICU after
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The effect of antifibrotic agents on acute respiratory failure in COVID-19 patients: a retrospective cohort study from TriNetX US collaborative networks BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-02 Hsin-Yi Wang, Shih-Chuan Tsai, Yi-Ching Lin, Jing-Uei Hou, Chih-Hao Chao
The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on global health and economies, resulting in millions of infections and deaths. This retrospective cohort study aimed to investigate the effect of antifibrotic agents (nintedanib and pirfenidone) on 1-year mortality in COVID-19 patients with acute respiratory failure. Data from 61 healthcare organizations in the TriNetX database
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Folate-modified liposomes mediate the co-delivery of cisplatin with miR-219a-5p for the targeted treatment of cisplatin-resistant lung cancer BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-01 Yuanlin Wu, Jiandong Zhang, Junjun Zhao, Bin Wang
Cisplatin (DDP) resistance, often leading to first-line chemotherapy failure in non-small cell lung cancer (NSCLC), poses a significant challenge. MiR-219a-5p has been reported to enhance the sensitivity of human NSCLC to DDP. However, free miR-219a-5p is prone to degradation by nucleases in the bloodstream, rendering it unstable. In light of this, our study developed an efficient nanodrug delivery
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Anti-synthetase syndrome in a child with pneumomediastinum: a case report and literature review BMC Pulm. Med. (IF 3.1) Pub Date : 2024-04-01 Jieqiong Lin, Yaowen Li, Qimeng Fan, Longwei Sun, Weisheng Sun, Xin Zhao, Hongwu Zeng
Anti-synthetase syndrome (ASS) is a group of rare clinical subtypes within inflammatory myopathies, predominantly affecting adult females. Instances of critical illness associated with ASS in children are even rarer. We report the case of a 7-year-old boy finally diagnosed with ASS, combined with pneumomediastinum. He presented with intermittent fever persisting for 12 days, paroxysmal cough for 11 days
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Impact of obesity on outcomes of extracorporeal membrane oxygenation support: a systematic review and meta-analysis BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-28 Xinhua Huang, Xiaoqing Lin
Extracorporeal membrane oxygenation (ECMO) is used when standard methods of standard treatment methods are not successful. Obese patients present unique challenges during ECMO due to large body size hindering sufficient flows, difficulties with patient positioning and anatomical landmark identification, and restricted radiology scans. This meta-analysis aims to investigate the impact of obesity on
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Clinical characteristics and effects of inhaled corticosteroid in patients with post-COVID-19 chronic cough during the Omicron variant outbreak BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-27 Pan-Pan Xie, Yue Zhang, Wen-Kai Niu, Bo Tu, Ning Yang, Yun Fang, Ying-Hui Shi, Fu-Sheng Wang, Xin Yuan
Chronic cough is a common symptom in patients post the coronavirus disease 2019 (COVID-19). In this study, we aimed to investigate the efficacy of inhaled corticosteroids (ICS) and the clinical characteristics of patients with post-COVID-19 chronic cough during the Omicron era. An ambispective, longitudinal cohort study was conducted that included patients with post-COVID-19 who attended the respiratory
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Immature central tumor tertiary lymphoid structures are associated with better prognosis in non-small cell lung cancer BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-26 Deng Xiaoxu, Xu Min, Cao Chengcheng
Tertiary lymphoid structures (TLSs) are predictive biomarkers of favorable clinical outcomes and immunotherapy response in several solid malignancies, including non-small cell lung cancer (NSCLC). However, the relationship between TLSs and NSCLC prognosis has not been eludicated from the aspects of location, density, and maturity. This study aimed to investigate the clinicopathological and prognostic
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Lung transcriptomics reveals the underlying mechanism by which aerobic training enhances pulmonary function in chronic obstructive pulmonary disease BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-26 Jian Li, Cai-tao Chen, Peijun Li, Xiaoyun Zhang, Xiaodan Liu, Weibing Wu, Wei Gu
Aerobic training is the primary method of rehabilitation for improving respiratory function in patients with chronic obstructive pulmonary disease (COPD) in remission. However, the mechanism underlying this improvement is not yet fully understood. The use of transcriptomics in rehabilitation medicine offers a promising strategy for uncovering the ways in which exercise training improves respiratory
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Screening and staging of chronic obstructive pulmonary disease with deep learning based on chest X-ray images and clinical parameters BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-26 XiaoLing Zou, Yong Ren, HaiLing Yang, ManMan Zou, Ping Meng, LiYi Zhang, MingJuan Gong, WenWen Ding, LanQing Han, TianTuo Zhang
Chronic obstructive pulmonary disease (COPD) is underdiagnosed with the current gold standard measure pulmonary function test (PFT). A more sensitive and simple option for early detection and severity evaluation of COPD could benefit practitioners and patients. In this multicenter retrospective study, frontal chest X-ray (CXR) images and related clinical information of 1055 participants were collected
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Efficacy of respiratory rehabilitation in patients with COVID-19: a retrospective study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-26 Zhiyou Zhang, Congcong Wang, Zhendong Li, Yueyang Liu, Yutong Nie, Jianwei Zhang, Dawei Li
The coronavirus disease 2019 (COVID-19) pandemic has resulted in millions of confirmed cases and deaths globally. The purpose of this study was to investigate the therapeutic effect of airway clearance technology combined with prone ventilation on patients infected with COVID-19. 38 patients with COVID-19 (severe) who were treated in the intensive rehabilitation group of Shengli Oilfield Central Hospital
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Occupational status and chronic respiratory diseases: a cross-sectional study based on the data of the Rafsanjan Cohort Study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-23 Zahra Bagheri-Hosseinabadi, Ali Bahreyni, Hosein Basirat, Parvin Khalili, Alireza Vakilian, Fatemeh Amin
The aim of the present study was to investigate the possible connection between occupational status and chronic respiratory diseases (CRDs) among the Iranian population. The present cross-sectional study was conducted on 9934 individuals aged 35–70 years enrolled in the Rafsanjan Cohort Study (RCS), a component of the Prospective Epidemiological Research Studies in Iran (PERSIAN). Detailed questionnaires
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Association between computed tomography-quantified respiratory muscles and chronic obstructive pulmonary disease: a retrospective study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-21 Ke Wang, Fan Wu, Hua He, Chengyi Hu, Xiaobang Chen, Jinglong Chen, Weitao Cao, Jun Liu, Jun Zhao, Ziwen Zhao, Zhuxiang Zhao
This study examined the association between chest muscles and chronic obstructive pulmonary disease (COPD) and the relationship between chest muscle areas and acute exacerbations of COPD (AECOPD). There were 168 subjects in the non-COPD group and 101 patients in the COPD group. The respiratory and accessory respiratory muscle areas were obtained using 3D Slicer software to analysis the imaging of computed
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Long-term multicenter comparison shows equivalent efficacy of monoclonal antibodies in severe asthma therapy BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-21 Moritz Z. Kayser, Hendrik Suhling, Jan Fuge, Christopher A. Hinze, Nora Drick, Nikolaus Kneidinger, Jürgen Behr, Christian Taube, Tobias Welte, Ina Haasler, Katrin Milger
Monoclonal antibodies (biologics) drastically changed severe asthma therapy. Mepolizumab (anti-interleukin (IL) 5), benralizumab (anti-IL5 receptor alpha), and dupilumab (anti-IL4/13) are the most used biologics in this context. While all biologics are efficient individually, the choice of biologic is complicated by insufficient data on their comparative long-term treatment efficacy. Here, we compare
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A RCT to explore the effectiveness of supporting adherence to nebuliser medication in adults with cystic fibrosis: fidelity assessment of study interventions BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-21 J. M. Bradley, M. Hutchings, M. A. Arden, A. O’Cathain, C. Maguire, M. J. Wildman
A multi-component self-management intervention ‘CFHealthHub’ was developed to reduce pulmonary exacerbations in adults with Cystic Fibrosis (CF) by supporting adherence to nebuliser medication. It was evaluated in a randomized controlled trial (RCT) involving 19 CF centres, with 32 interventionists, 305 participants in the intervention group, and 303 participants in the standard care arm. Ensuring
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Welding fume exposure and prevalence of chronic respiratory symptoms among welders in micro- and small-scale enterprise in Akaki Kality sub-city, Addis Ababa, Ethiopia: a comparative cross-sectional study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-20 Hager Badima, Abera Kumie, Bereket Meskele, Samson Wakuma Abaya
Exposure to welding fumes can lead to different respiratory health disorders, including lung cancer, due to long-term exposures. In Ethiopia, large numbers of people are engaged in the welding sector. Often, these workers are exposed to welding fumes at their workplaces, however, the level of exposure and its health effects have never been studied. To measure the level of personal welding fume exposure
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Virtual bronchoscopic navigation with intraoperative cone-beam CT for the diagnosis of peripheral pulmonary nodules BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-20 Jisong Zhang, Enguo Chen, Shan Xu, Li Xu, Huihui Hu, Liangliang Dong, Kejing Ying
Transbronchial biopsy is a safe manner with fewer complications than percutaneous transthoracic needle biopsy; however, the current diagnostic yield is still necessitating further improvement. We aimed to evaluate the diagnostic yield of using virtual bronchoscopic navigation (VBN) and cone-beam CT (CBCT) for transbronchial biopsy and to investigate the factors that affected the diagnostic sensitivity
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Exploring the causal relationship between immune cells and idiopathic pulmonary fibrosis: a bi-directional Mendelian randomization study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-20 Zhao He, Ruixin Wang, Chenghu Song, Jiwei Liu, Ruo Chen, Mingfeng Zheng, Weici Liu, Guanyu Jiang, Wenjun Mao
The potential pathogenic mechanism of idiopathic pulmonary fibrosis is widely recognized to involve immune dysregulation. However, the current pool of studies has yet to establish a unanimous agreement regarding the correlation between various types of immune cells and IPF. By conducting a two-sample Mendelian randomization analysis using publicly available genetic data, the study examined the causal
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The role of Neutrophil counts, infections and Smoking in mediating the Effect of Bronchiectasis on Chronic Obstructive Pulmonary Disease: a mendelian randomization study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-20 Lei Gu, Wei Liu, Jian-an Huang, Lujian Zhu, Xiaowen Hu, Jian Yue, Jing Lin
The causality of the relationship between bronchiectasis and chronic obstructive pulmonary disease (COPD) remains unclear. This study aims to investigate the potential causal relationship between them, with a specific focus on the role of airway inflammation, infections, smoking as the mediators in the development of COPD. We conducted a two-sample Mendelian randomization (MR) analysis to assess: (1)
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Design of the STRIVE-IPF trial- study of therapeutic plasma exchange, rituximab, and intravenous immunoglobulin for acute exacerbations of idiopathic pulmonary fibrosis BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-20 Tejaswini Kulkarni, Gerard J. Criner, Daniel J. Kass, Ivan O. Rosas, Mary Beth Scholand, Daniel F. Dilling, Ross Summer, Steven R. Duncan
Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) affect a significant proportion of patients with IPF. There are limited data to inform therapeutic strategies for AE-IPF, despite its high mortality. We discuss the rationale and design of STRIVE-IPF, a randomized, multi-center, open-label Phase IIb clinical trial to determine the efficacy of combined therapeutic plasma exchange (TPE), rituximab
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Diabetes mellitus and idiopathic pulmonary fibrosis: a Mendelian randomization study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-20 Quou Kang, Jing Ren, Jinpeng Cong, Wencheng Yu
The question as to whether or not diabetes mellitus increases the risk of idiopathic pulmonary fibrosis (IPF) remains controversial. This study aimed to investigate the causal association between type 1 diabetes (T1D), type 2 diabetes (T2D), and IPF using Mendelian randomization (MR) analysis. We used two-sample univariate and multivariate MR (MVMR) analyses to investigate the causal relationship between
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Association between nintedanib adherence trajectory and healthcare use among idiopathic pulmonary fibrosis patients BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-19 Mona Nili, Andrew J. Epstein, Dominic Nunag, Amy Olson, Bijan J Borah
Although inverse associations have been found between medication adherence and healthcare use and spending outcomes in many clinical settings, no studies to date have examined these relationships for patients with idiopathic pulmonary fibrosis (IPF) initiating nintedanib. We build on our prior study that used group-based trajectory modeling (GBTM) to compare inpatient hospitalization and medical care
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Vitamin C deficiency can lead to pulmonary hypertension: a systematic review of case reports BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-19 Harri Hemilä, Angelique M.E. de Man
In the early literature, unintentional vitamin C deficiency in humans was associated with heart failure. Experimental vitamin C deficiency in guinea pigs caused enlargement of the heart. The purpose of this study was to collect and analyze case reports on vitamin C and pulmonary hypertension. We searched Pubmed and Scopus for case studies in which vitamin C deficiency was considered to be the cause
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Virtual pulmonary rehabilitation approaches in patients with post COVID syndrome: a pilot study BMC Pulm. Med. (IF 3.1) Pub Date : 2024-03-18 Antonio Sarmento, Rachel Adodo, Greg Hodges, Sandra C. Webber, Diana C. Sanchez-Ramirez
The characteristics of optimal virtual pulmonary rehabilitation (PR) for individuals with post-COVID syndrome (PCS) have not been identified. This study aimed to assess the feasibility, safety, and satisfaction associated with a virtual PR program with the exercise component delivered through group or self-directed sessions. Adults with PCS-respiratory symptoms were randomly assigned to the video conference