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Decreased serpin C1 in extracellular vesicles predicts response to methotrexate treatment in patients with pulmonary sarcoidosis Respir. Res. (IF 5.8) Pub Date : 2024-04-16 Raisa Kraaijvanger, Montse Janssen Bonás, Jan C. Grutters, Ioanna Paspali, Marcel Veltkamp, Dominique P. V. de Kleijn, Coline H. M. van Moorsel
Sarcoidosis is a systemic granulomatous disease of unknown etiology primarily affecting the lungs. Treatment is needed when disease symptoms worsen and organ function deteriorates. In pulmonary sarcoidosis, prednisone and methotrexate (MTX) are the most common anti-inflammatory therapies. However, there is large inter-patient variability in response to treatment, and predictive response markers are
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Human genetic associations of the airway microbiome in chronic obstructive pulmonary disease Respir. Res. (IF 5.8) Pub Date : 2024-04-16 Jingyuan Gao, Yuqiong Yang, Xiaopeng Xiang, Huimin Zheng, Xinzhu Yi, Fengyan Wang, Zhenyu Liang, Dandan Chen, Weijuan Shi, Lingwei Wang, Di Wu, Shengchuan Feng, Qiaoyun Huang, Xueping Li, Wensheng Shu, Rongchang Chen, Nanshan Zhong, Zhang Wang
Little is known about the relationships between human genetics and the airway microbiome. Deeply sequenced airway metagenomics, by simultaneously characterizing the microbiome and host genetics, provide a unique opportunity to assess the microbiome-host genetic associations. Here we performed a co-profiling of microbiome and host genetics with the identification of over 5 million single nucleotide
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Effects of right ventricular remodeling in chronic thromboembolic pulmonary hypertension on the outcomes of balloon pulmonary angioplasty: a 2D-speckle tracking echocardiography study Respir. Res. (IF 5.8) Pub Date : 2024-04-15 Yaning Ma, Dichen Guo, Jianfeng Wang, Juanni Gong, Huimin Hu, Xinyuan Zhang, Yeqing Wang, Yuanhua Yang, Xiuzhang Lv, Yidan Li
Balloon pulmonary angioplasty (BPA) improves the prognosis of chronic thromboembolic pulmonary hypertension (CTEPH). Right ventricle (RV) is an important predictor of prognosis in CTEPH patients. 2D-speckle tracking echocardiography (2D-STE) can evaluate RV function. This study aimed to evaluate the effectiveness of BPA in CTEPH patients and to assess the value of 2D-STE in predicting outcomes of BPA
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Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen Respir. Res. (IF 5.8) Pub Date : 2024-04-15 Melissa A. Kovach, Ulrika Käck, Karlhans F Che, Bettina Brundin, Jon R. Konradsen, Anders Lindén
Interleukin (IL)-26 is produced by T helper type 17 (Type 17) cells and exerts immunomodulatory plus antimicrobial effects. Previous studies show that local IL-26 concentrations in the airways are higher in patients with uncontrolled than in those with controlled asthma, and that this intriguing cytokine bears biomarker potential. Here, we determined how systemic IL-26 relates to allergen sensitization
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Feasibility and acceptability of remotely monitoring spirometry and pulse oximetry as part of interstitial lung disease clinical care: a single arm observational study Respir. Res. (IF 5.8) Pub Date : 2024-04-15 Sarah Barth, Colin Edwards, Gauri Saini, Yussef Haider, Nicholas Paul Williams, Will Storrar, Gisli Jenkins, Iain Stewart, Melissa Wickremasinghe
Remote monitoring of patient-recorded spirometry and pulse oximetry offers an alternative approach to traditional hospital-based monitoring of interstitial lung disease (ILD). Remote spirometry has been observed to reasonably reflect clinic spirometry in participants with ILD but remote monitoring has not been widely incorporated into clinical practice. We assessed the feasibility of remotely monitoring
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Early-life house dust mite aeroallergen exposure augments cigarette smoke-induced myeloid inflammation and emphysema in mice Respir. Res. (IF 5.8) Pub Date : 2024-04-13 Nok Him Fung, Quynh Anh Nguyen, Catherine Owczarek, Nick Wilson, Nadeem Elahee Doomun, David De Souza, Kylie Quinn, Stavros Selemidis, Jonathan McQualter, Ross Vlahos, Hao Wang, Steven Bozinovski
Longitudinal studies have identified childhood asthma as a risk factor for obstructive pulmonary disease (COPD) and asthma-COPD overlap (ACO) where persistent airflow limitation can develop more aggressively. However, a causal link between childhood asthma and COPD/ACO remains to be established. Our study aimed to model the natural history of childhood asthma and COPD and to investigate the cellular/molecular
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Loss of ZNF451 mediates fibroblast activation and promotes lung fibrosis Respir. Res. (IF 5.8) Pub Date : 2024-04-10 Hong Peng, Yu Zhang, Jiali Min, Yuexin Tan, Shanshan Liu
No effective therapies for pulmonary fibrosis (PF) exist because of the unclear molecular pathogenesis and the lack of effective therapeutic targets. Zinc finger protein 451 (ZNF451), a transcriptional regulator, plays crucial roles in the pathogenesis of several diseases. However, its expression pattern and function in PF remain unknown. This study was designed to investigate the role of ZNF451 in
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Phenotypes and outcome of diffuse pulmonary non-amyloid light chain deposition disease Respir. Res. (IF 5.8) Pub Date : 2024-04-10 François Lestelle, Catherine Beigelman, David Rotzinger, Salim Si-Mohamed, Mouhamad Nasser, Lidwine Wemeau, Sandrine Hirschi, Grégoire Prevot, Antoine Roux, Vincent Bunel, Emmanuel Gomez, Laurent Sohier, Helene Morisse Pradier, Martine Reynaud Gaubert, Anne Gondouin, Romain Lazor, Jean-Charles Glerant, Françoise Thivolet Bejui, Magali Colombat, Vincent Cottin
Light chain deposition disease (LCDD) is a very rare entity. Clinical manifestations of LCDD vary according to the organs involved. Data on pulmonary LCDD are scarce and limited to small series or case reports. This study aimed to describe the characteristics and outcome of diffuse pulmonary non-amyloid LCDD localized to the lungs. A multicenter retrospective cohort study was conducted. Clinical characteristics
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GLUT3-mediated cigarette smoke-induced epithelial-mesenchymal transition in chronic obstructive pulmonary disease through the NF-kB/ZEB1 pathway Respir. Res. (IF 5.8) Pub Date : 2024-04-09 Yu Ding, Ziteng Wang, Zheming Zhang, Rong You, Yan Wu, Tao Bian
Airway remodelling plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Epithelial–mesenchymal transition (EMT) is a significant process during the occurrence of airway remodelling. Increasing evidence suggests that glucose transporter 3 (GLUT3) is involved in the epithelial mesenchymal transition (EMT) process of various diseases. However, the role of GLUT3
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Targeting transitioning lung monocytes/macrophages as treatment strategies in lung disease related to environmental exposures Respir. Res. (IF 5.8) Pub Date : 2024-04-09 Aaron D. Schwab, Todd A. Wyatt, Grace Moravec, Geoffrey M. Thiele, Amy J. Nelson, Angela Gleason, Oliver Schanze, Michael J. Duryee, Debra J. Romberger, Ted R. Mikuls, Jill A. Poole
Environmental/occupational exposures cause significant lung diseases. Agricultural organic dust extracts (ODE) and bacterial component lipopolysaccharide (LPS) induce recruited, transitioning murine lung monocytes/macrophages, yet their cellular role remains unclear. CCR2 RFP+ mice were intratracheally instilled with high concentration ODE (25%), LPS (10 μg), or gram-positive peptidoglycan (PGN, 100 μg)
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Use of non-small cell lung cancer multicellular tumor spheroids to study the impact of chemotherapy Respir. Res. (IF 5.8) Pub Date : 2024-04-05 Pauline Hulo, Sophie Deshayes, Judith Fresquet, Anne-Laure Chéné, Stéphanie Blandin, Nicolas Boisgerault, Jean-François Fonteneau, Lucas Treps, Marc G Denis, Jaafar Bennouna, Delphine Fradin, Elvire Pons-Tostivint, Christophe Blanquart
Lung cancers represent the main cause of cancer related-death worldwide. Recently, immunotherapy alone or in combination with chemotherapy has deeply impacted the therapeutic care leading to an improved overall survival. However, relapse will finally occur, with no efficient second line treatment so far. New therapies development based on the comprehension of resistance mechanisms is necessary. However
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Updated reference values for static lung volumes from a healthy population in Austria Respir. Res. (IF 5.8) Pub Date : 2024-04-03 Tobias Mraz, Shervin Asgari, Ahmad Karimi, Marie-Kathrin Breyer, Sylvia Hartl, Owat Sunanta, Alina Ofenheimer, Otto C. Burghuber, Angela Zacharasiewicz, Bernd Lamprecht, Caspar Schiffers, Emiel F. M. Wouters, Robab Breyer-Kohansal
Reference values for lung volumes are necessary to identify and diagnose restrictive lung diseases and hyperinflation, but the values have to be validated in the relevant population. Our aim was to investigate the Global Lung Function Initiative (GLI) reference equations in a representative healthy Austrian population and create population-derived reference equations if poor fit was observed. We analysed
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NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence Respir. Res. (IF 5.8) Pub Date : 2024-04-02 Ruyan Wan, Siqi Long, Shuaichen Ma, Peishuo Yan, Zhongzheng Li, Kai Xu, Hui Lian, Wenwen Li, Yudi Duan, Miaomiao Zhu, Lan Wang, Guoying Yu
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fatal, and aging-associated interstitial lung disease with a poor prognosis and limited treatment options, while the pathogenesis remains elusive. In this study, we found that the expression of nuclear receptor subfamily 2 group F member 2 (NR2F2), a member of the steroid thyroid hormone superfamily of nuclear receptors, was reduced in
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A WNT mimetic with broad spectrum FZD-specificity decreases fibrosis and improves function in a pulmonary damage model Respir. Res. (IF 5.8) Pub Date : 2024-04-02 Mehaben Patel, Yorick Post, Natalie Hill, Asmiti Sura, Jay Ye, Trevor Fisher, Nicholas Suen, Mengrui Zhang, Leona Cheng, Ariel Pribluda, Hui Chen, Wen-Chen Yeh, Yang Li, Hélène Baribault, Russell B. Fletcher
Wnt/β-catenin signaling is critical for lung development and AT2 stem cell maintenance in adults, but excessive pathway activation has been associated with pulmonary fibrosis, both in animal models and human diseases such as idiopathic pulmonary fibrosis (IPF). IPF is a detrimental interstitial lung disease, and although two approved drugs limit functional decline, transplantation is the only treatment
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Correction: Benefit of prompt initiation of single-inhaler fluticasone furoate, umeclidinium, and vilanterol (FF/UMEC/VI) in patients with COPD in England following an exacerbation: a retrospective cohort study Respir. Res. (IF 5.8) Pub Date : 2024-04-01 Afisi S. Ismaila, Kieran J. Rothnie, Robert P. Wood, Victoria L. Banks, Lucinda J. Camidge, Alexandrosz Czira, Chris Compton, Raj Sharma, Shannon N. Millard, Olivia Massey, David M. G. Halpin
Correction: Respiratory Research (2023) 24: 229 https://doi.org/10.1186/s12931-023-02523-1 Following publication of the original article [1], the Authors identified errors in the COPD-related total costs for prompt and delayed initiators and the associated exponentiated coefficient (95% confidence interval) and p-value in Fig. 8b. The corrected Fig. 8b is given below: These errors also impacted some
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The safety and potential efficacy of exosomes overexpressing CD24 (EXO-CD24) in mild-moderate COVID-19 related ARDS Respir. Res. (IF 5.8) Pub Date : 2024-04-01 Ioannis Grigoropoulos, Georgios Tsioulos, Artemis Kastrissianakis, Shiran Shapira, Orr Green, Vasiliki Rapti, Maria Tsakona, Thomas Konstantinos, Athina Savva, Dimitra Kavatha, Dimitrios Boumpas, Konstantinos Syrigos, Ioannis Xynogalas, Konstantinos Leontis, Vasileios Ntousopoulos, Vissaria Sakka, Zafeiris Sardelis, Andreas Fotiadis, Lamprini Vlassi, Chrysoula Kontogianni, Anastasia Levounets, Garyfalia
EXO-CD24 are exosomes genetically manipulated to over-express Cluster of Differentiation (CD) 24. It consists of two breakthrough technologies: CD24, the drug, as a novel immunomodulator that is smarter than steroids without any side effects, and exosomes as the ideal natural drug carrier. A randomized, single blind, dose-finding phase IIb trial in hospitalized patients with mild to moderate Coronavirus
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Longitudinal BMI change and outcomes in Chronic Obstructive Pulmonary Disease: a nationwide population-based cohort study Respir. Res. (IF 5.8) Pub Date : 2024-03-30 Taeyun Kim, Sun Hye Shin, Hyunsoo Kim, Yunjoo Im, Juhee Cho, Danbee Kang, Hye Yun Park
The association between longitudinal body mass index (BMI) change and clinical outcomes in patients with chronic obstructive pulmonary disease (COPD) has not fully investigated. This retrospective cohort study included 116,463 COPD patients aged ≥ 40, with at least two health examinations, one within 2 years before and another within 3 years after COPD diagnosis (January 1, 2014, to December 31, 2019)
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Clinical characterization and outcomes of impulse oscillometry-defined bronchodilator response: an ECOPD cohort-based study Respir. Res. (IF 5.8) Pub Date : 2024-03-30 Lifei Lu, Fan Wu, Jieqi Peng, Xiaohui Wu, Xiangqing Hou, Youlan Zheng, Huajing Yang, Zhishan Deng, Cuiqiong Dai, Ningning Zhao, Kunning Zhou, Qi Wan, Gaoying Tang, Jiangyu Cui, Shuqing Yu, Xiangwen Luo, Changli Yang, Shengtang Chen, Pixin Ran, Yumin Zhou
The clinical significance of the impulse oscillometry-defined small airway bronchodilator response (IOS-BDR) is not well-known. Accordingly, this study investigated the clinical characteristics of IOS-BDR and explored the association between lung function decline, acute respiratory exacerbations, and IOS-BDR. Participants were recruited from an Early Chronic Obstructive Pulmonary Disease (ECOPD) cohort
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Astaxanthin attenuates cigarette smoke-induced small airway remodeling via the AKT1 signaling pathway Respir. Res. (IF 5.8) Pub Date : 2024-03-30 Haidong Ding, Liming Yan, Yu Wang, Ye Lu, Mingming Deng, Yingxi Wang, Qiuyue Wang, Xiaoming Zhou
Astaxanthin (AXT) is a keto-carotenoid with a variety of biological functions, including antioxidant and antifibrotic effects. Small airway remodeling is the main pathology of chronic obstructive pulmonary disease (COPD) and is caused by epithelial-to-mesenchymal transition (EMT) and fibroblast differentiation and proliferation. Effective therapies are still lacking. This study aimed to investigate
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Novel insights and new therapeutic potentials for macrophages in pulmonary hypertension Respir. Res. (IF 5.8) Pub Date : 2024-03-30 Yifan Zuo, Boyang Li, Minglang Gao, Rui Xiong, Ruyuan He, Ning Li, Qing Geng
Inflammation and immune processes underlie pulmonary hypertension progression. Two main different activated phenotypes of macrophages, classically activated M1 macrophages and alternatively activated M2 macrophages, are both involved in inflammatory processes related to pulmonary hypertension. Recent advances suggest that macrophages coordinate interactions among different proinflammatory and anti-inflammatory
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A novel quinoline with airway relaxant effects and anti-inflammatory properties Respir. Res. (IF 5.8) Pub Date : 2024-03-30 Jesper Bergwik, Jielu Liu, Médea Padra, Ravi K. V. Bhongir, Lloyd Tanner, Yujiao Xiang, Mia Lundblad, Arne Egesten, Mikael Adner
In chronic pulmonary diseases characterized by inflammation and airway obstruction, such as asthma and COPD, there are unmet needs for improved treatment. Quinolines is a group of small heterocyclic compounds that have a broad range of pharmacological properties. Here, we investigated the airway relaxant and anti-inflammatory properties of a novel quinoline (RCD405). The airway relaxant effect of RCD405
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Patients’ evaluation of aftercare following hospitalization for COVID-19: satisfaction and unmet needs Respir. Res. (IF 5.8) Pub Date : 2024-03-29 Julia C. Berentschot, Willemijn A. de Ridder, L. Martine Bek, Majanka H. Heijenbrok-Kal, Gert-Jan Braunstahl, Sylvia C. Remerie, Yvonne Stuip, Gerard M. Ribbers, Joachim G. J. V. Aerts, Erwin Ista, Merel E. Hellemons, Rita J. G. van den Berg-Emons
Patient experiences with COVID-19 aftercare remain largely unknown. We evaluated COVID-19 aftercare from a patient perspective one year after hospitalization, assessing satisfaction and its associated factors, and unmet needs. The Satisfaction with COVID-19 Aftercare Questionnaire (SCAQ) was developed as part of a multicenter prospective cohort study and administered one year after hospital discharge
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Development of a nomogram based on the clinicopathological and CT features to predict the survival of primary pulmonary lymphoepithelial carcinoma patients Respir. Res. (IF 5.8) Pub Date : 2024-03-29 Kai Nie, Lin Zhu, Yuxuan Zhang, Yinan Chen, John Parrington, Hong Yu
The aim of this study was to develop a nomogram by combining chest computed tomography (CT) images and clinicopathological predictors to assess the survival outcomes of patients with primary pulmonary lymphoepithelial carcinoma (PLEC). 113 patients with stage I–IV primary PLEC who underwent treatment were retrospectively reviewed. The Cox regression analysis was performed to determine the independent
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Association between the ROX index and mortality in patients with acute hypoxemic respiratory failure: a retrospective cohort study Respir. Res. (IF 5.8) Pub Date : 2024-03-29 Kai Liu, Xin-Yi Ma, Hua Xiao, Wan-Jie Gu, Jun Lyu, Hai-Yan Yin
Although ROX index is frequently used to assess the efficacy of high-flow nasal cannula treatment in acute hypoxemic respiratory failure (AHRF) patients, the relationship between the ROX index and the mortality remains unclear. Therefore, a retrospective cohort study was conducted to evaluate the ability of the ROX index to predict mortality risk in patients with AHRF. Patients diagnosed with AHRF
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Respiratory entrainment related reverse triggering in mechanically ventilated children Respir. Res. (IF 5.8) Pub Date : 2024-03-25 Robert G.T. Blokpoel, Ruben B.R. Brandsema, Alette A. Koopman, Jefta van Dijk, Martin C.J. Kneyber
The underlying pathophysiological pathways how reverse triggering is being caused are not fully understood. Respiratory entrainment may be one of these mechanisms, but both terms are used interchangeably. We sought to characterize reverse triggering and the relationship with respiratory entrainment among mechanically ventilated children with and without acute lung injury. We performed a secondary phyiology
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Are there over 200 distinct types of interstitial lung diseases? Respir. Res. (IF 5.8) Pub Date : 2024-03-25 Joseph C. Cooley, Evans R. Fernández Pérez
Interstitial lung diseases (ILD) are a heterogeneous group of complex disorders with varying presentations, prognoses, and responsiveness to drugs. The review by Amati and colleagues elegantly illustrates how historically ILD recognition has evolved from a handful group of histological categories described in the 1960s to the 1990s first radiological-histological classification to today’s collection
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Early smoking lead to worse prognosis of COPD patients: a real world study Respir. Res. (IF 5.8) Pub Date : 2024-03-25 Jiankang Wu, Weiwei Meng, Yiming Ma, Zhiqi Zhao, Ruoyan Xiong, Jiayu Wang, Rui Zhao, Huihui Zeng, Yan Chen
Smoking remains a major risk factor for the development and progression of chronic obstructive pulmonary disease (COPD). Due to the adolescent smoking associated with worse health state, the age, at which an individual started smoking, might play a key role in shaping the trajectory of COPD development and the severity. We conducted an observational study from September 2016 through January 2023 of
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Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters Respir. Res. (IF 5.8) Pub Date : 2024-03-23 Yuan-Ting Hsu, Chao-Chien Wu, Chin-Chou Wang, Chau-Chyun Sheu, Yi-Hsin Yang, Ming-Yen Cheng, Ruay-Sheng Lai, Sum-Yee Leung, Chi-Cheng Lin, Yu-Feng Wei, Yung-Fa Lai, Meng-Hsuan Cheng, Huang-Chi Chen, Chih-Jen Yang, Chien-Jen Wang, Huei-Ju Liu, Hua-Ling Chen, Chih-Hsing Hung, Chon-Lin Lee, Ming-Shyan Huang, Shau-Ku Huang
DEHP, a common plasticizer known for its hormone-disrupting properties, has been associated with asthma. However, a significant proportion of adult asthma cases are “non-atopic”, lacking a clear etiology. In a case-control study conducted between 2011 and 2015, 365 individuals with current asthma and 235 healthy controls from Kaohsiung City were enrolled. The control group comprised individuals without
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The role of lung biopsy for diagnosis and prognosis of interstitial lung disease in systemic sclerosis: a systematic literature review Respir. Res. (IF 5.8) Pub Date : 2024-03-23 A Damiani, M Orlandi, C Bruni, G Bandini, G Lepri, C Scaletti, C Ravaglia, F Frassanito, S Guiducci, A Moggi-Pignone, M Matucci-Cerinic, V Poletti, L Tofani, TV Colby, S Bellando Randone, Sara Tomassetti
The prognostic and theragnostic role of histopathological subsets in systemic sclerosis interstitial lung disease (SSc-ILD) have been largely neglected due to the paucity of treatment options and the risks associated with surgical lung biopsy. The novel drugs for the treatment of ILDs and the availability of transbronchial cryobiopsy provide a new clinical scenario making lung biopsy more feasible
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Editorial for special issue—human precision cut lung slices: an Ex vivo platform for therapeutic target discovery and drug testing in lung disease Respir. Res. (IF 5.8) Pub Date : 2024-03-23 Cynthia J. Koziol-White, Reynold A. Panettieri Jr.
Publications utilizing precision cut lung slices (PCLS) steadily increased from the 1970’s, with a significant increase in 2010, to tripling by 2023. PCLS have been used to study a vast array of pulmonary diseases and exposures to pathogens and toxicants to understand pathogenesis of disease but also to examine basic cellular mechanisms that underly lung biology. This Special Issue will highlight new
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Correction: Silencing of CD147 inhibits cell proliferation, migration, invasion, lipid metabolism dysregulation and promotes apoptosis in lung adenocarcinoma via blocking the Rap1 signaling pathway Respir. Res. (IF 5.8) Pub Date : 2024-03-21 Ning Zhang, Zhouzhong Liu, Xuwang Lai, Shubin Liu, Yuli Wang
Correction: Respiratory Research (2023) 24:253 https://doi.org/10.1186/s12931-023-02532-0 Following publication of the original article [1], the authors identified that Figs. 1 and 2 were inadvertently swapped. Fig. 1 Silencing of CD147 inhibited the proliferation, migration, invasion, and lipid metabolism of LUAD cells. A The mRNA expression of CD147 in two LUAD cell lines (A549 and H1299 cells) and
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Evaluation of computed tomography in the diagnosis of ultrasound-proven diaphragm dysfunction Respir. Res. (IF 5.8) Pub Date : 2024-03-20 Pauline Lallement, Alain Boussuges, Paul Habert, Julien Bermudez, Martine Reynaud-Gaubert, Stéphane Delliaux, Fabienne Bregeon, Benjamin Coiffard
Computed tomography (CT) is routinely employed on the evaluation of dyspnea, yet limited data exist on its assessment of diaphragmatic muscle. This study aimed to determine the capability of CT in identifying structural changes in the diaphragm among patients with ultrasound-confirmed diaphragmatic dysfunction. Diaphragmatic ultrasounds conducted between 2018 and 2021 at our center in Marseille, France
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The role of sialidase Neu1 in respiratory diseases Respir. Res. (IF 5.8) Pub Date : 2024-03-19 Shiran Mei, Dingding Li, Aoyi Wang, Guoxue Zhu, Bingwen Zhou, Nian Li, Yi Qin, Yanliang Zhang, Shujun Jiang
Neu1 is a sialidase enzyme that plays a crucial role in the regulation of glycosylation in a variety of cellular processes, including cellular signaling and inflammation. In recent years, numerous evidence has suggested that human NEU1 is also involved in the pathogenesis of various respiratory diseases, including lung infection, chronic obstructive pulmonary disease (COPD), asthma, and pulmonary fibrosis
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Impact of smoking reduction on lung cancer risk in patients with COPD who smoked fewer than 30 pack-years: a nationwide population-based cohort study Respir. Res. (IF 5.8) Pub Date : 2024-03-18 Sun Hye Shin, Taeyun Kim, Hyunsoo Kim, Juhee Cho, Danbee Kang, Hye Yun Park
The effects of smoking reduction on the incidence of lung cancer in patients with chronic obstructive pulmonary disease (COPD) are not well known. This study aimed to investigate the effects of changes in smoking habits after COPD diagnosis on lung cancer development in patients who smoked less than 30 pack-years. This nationwide retrospective cohort study included 16,832 patients with COPD who smoked
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The additional value of 18F-FDG PET/CT imaging in guiding the treatment strategy of non-tuberculous mycobacterial patients Respir. Res. (IF 5.8) Pub Date : 2024-03-18 Donghe Chen, Yunbo Chen, Shuye Yang, Kanfeng Liu, Zhen Wang, Tingting Zhang, Guolin Wang, Kui Zhao, Xinhui Su
Non-tuberculous mycobacteria (NTM) infection is an increasing health problem due to delaying an effective treatment. However, there are few data on 18F-FDG PET/CT for evaluating the status of NTM patients. The aim of this study was to investigate the potential value of 18F-FDG PET/CT in guiding the treatment strategy of NTM patients. We retrospectively analyzed the cases of 23 NTM patients who underwent
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Two single lung transplantations from one donor: lung twinning in the LAS era Respir. Res. (IF 5.8) Pub Date : 2024-03-18 Frank Langer, Philipp M. Lepper, Bettina Weingard, Parviz Aliyev, Robert Bals, Heinrike Wilkens
The implementation of the Lung Allocation Score (LAS) in the Eurotransplant international collaborative framework decreased waiting list mortality, but organ shortage remains a significant problem. Transplantation of two single lungs from one donor into two recipients (lung twinning) may decrease waiting list mortality. We sought to analyze if this strategy can lead to an acceptable intermediate-term
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Tobacco use, self-reported professional dental cleaning habits, and lung adenocarcinoma diagnosis are associated with bronchial and lung microbiome alpha diversity Respir. Res. (IF 5.8) Pub Date : 2024-03-18 Alexa A. Pragman, Shane W. Hodgson, Tianhua Wu, Allison Zank, Rosemary F. Kelly, Cavan S. Reilly, Chris H. Wendt
The lung microbiome is an inflammatory stimulus whose role in the development of lung malignancies is incompletely understood. We hypothesized that the lung microbiome associates with multiple clinical factors, including the presence of a lung malignancy. To assess associations between the upper and lower airway microbiome and multiple clinical factors including lung malignancy. We conducted a prospective
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Lung tissue expression of epithelial injury markers is associated with acute lung injury severity but does not discriminate sepsis from ARDS Respir. Res. (IF 5.8) Pub Date : 2024-03-18 Natália de Souza Xavier Costa, Giovana da Costa Sigrist, Alexandre Santos Schalch, Luciano Belotti, Marisa Dolhnikoff, Luiz Fernando Ferraz da Silva
Acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in critically ill patients, and diffuse alveolar damage (DAD) is considered its histological hallmark. Sepsis is one of the most common aetiology of ARDS with the highest case-fatality rate. Identifying ARDS patients and differentiate them from other causes of acute respiratory failure remains a challenge. To address
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Cough flows as a criterion for decannulation of autonomously breathing patients with tracheostomy tubes Respir. Res. (IF 5.8) Pub Date : 2024-03-18 Jingyi Ge, Guangyu Niu, Qing Li, Yi Li, Bo Yang, Haiming Guo, Jianjun Wang, Bin Zhang, Chenxi Zhang, Ting Zhou, Zhanqi Zhao, Hongying Jiang
Adequate cough or exsufflation flow can indicate an option for safe tracheostomy decannulation to noninvasive management. Cough peak flow via the upper airways with the tube capped is an outcome predictor for decannulation readiness in patients with neuromuscular impairment. However, this threshold value is typically measured with tracheotomy tube removed, which is not acceptable culturally in China
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Exertional breathlessness related to medical conditions in middle-aged people: the population-based SCAPIS study of more than 25,000 men and women Respir. Res. (IF 5.8) Pub Date : 2024-03-16 Magnus Ekström, Josefin Sundh, Anders Andersson, Oskar Angerås, Anders Blomberg, Mats Börjesson, Kenneth Caidahl, Össur Ingi Emilsson, Jan Engvall, Erik Frykholm, Ludger Grote, Kristofer Hedman, Tomas Jernberg, Eva Lindberg, Andrei Malinovschi, André Nyberg, Eric Rullman, Jacob Sandberg, Magnus Sköld, Nikolai Stenfors, Johan Sundström, Hanan Tanash, Suneela Zaigham, Carl-Johan Carlhäll
Breathlessness is common in the population and can be related to a range of medical conditions. We aimed to evaluate the burden of breathlessness related to different medical conditions in a middle-aged population. Cross-sectional analysis of the population-based Swedish CArdioPulmonary bioImage Study of adults aged 50–64 years. Breathlessness (modified Medical Research Council [mMRC] ≥ 2) was evaluated
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Identifying a survival-associated cell type based on multi-level transcriptome analysis in idiopathic pulmonary fibrosis Respir. Res. (IF 5.8) Pub Date : 2024-03-15 Fei Xu, Yun Tong, Wenjun Yang, Yiyang Cai, Meini Yu, Lei Liu, Qingkang Meng
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a five-year survival rate of less than 40%. There is significant variability in survival time among IPF patients, but the underlying mechanisms for this are not clear yet. We collected single-cell RNA sequence data of 13,223 epithelial cells taken from 32 IPF patients and bulk RNA sequence data from 456 IPF patients in GEO. Based on
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Alterations of lung microbiota in lung transplant recipients with pneumocystis jirovecii pneumonia Respir. Res. (IF 5.8) Pub Date : 2024-03-14 Qiaoyan Lian, Xiuling Song, Juhua Yang, Lulin Wang, Peihang Xu, Xiaohua Wang, Xin Xu, Bin Yang, Jianxing He, Chunrong Ju
Increasing evidence revealed that lung microbiota dysbiosis was associated with pulmonary infection in lung transplant recipients (LTRs). Pneumocystis jirovecii (P. jirovecii) is an opportunistic fungal pathogen that frequently causes lethal pneumonia in LTRs. However, the lung microbiota in LTRs with P. jirovecii pneumonia (PJP) remains unknow. In this prospective observational study, we performed
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Efficacy and safety of Infliximab in systemic sarcoidosis according to GenPhenReSa organ-involvement phenotype: a retrospective study of 55 patients Respir. Res. (IF 5.8) Pub Date : 2024-03-14 Etienne Rivière, Wendy Jourde, Noémie Gensous, Xavier Demant, Emmanuel Ribeiro, Pierre Duffau, Patrick Mercié, Jean-François Viallard, Estibaliz Lazaro
Infliximab is currently recommended as a third-line treatment for refractory sarcoidosis. Data in function of clinical phenotype are currently lacking. We evaluated patients’ characteristics and responses to infliximab according to their GenPhenReSa cluster. We evaluated clinical and biological characteristics of patients diagnosed with sarcoidosis who received infliximab between September 2008 and
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Variables associated with antibiotic treatment tolerance in patients with Mycobacterium avium complex pulmonary disease Respir. Res. (IF 5.8) Pub Date : 2024-03-11 Meghan Marmor, Husham Sharifi, Susan Jacobs, Kiana Fazeli, Stephen Ruoss
Treatment of Mycobacterium avium complex pulmonary disease (MAC-PD) involves prolonged courses of multiple antibiotics that are variably tolerated and commonly cause adverse drug reactions (ADR). The purpose of this retrospective, single-center study was to identify demographic and disease-related variables associated with significant ADRs among patients treated with antibiotics against MAC-PD. We
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Associations of a plant-centered diet and lung function across early to mid-adulthood: The CARDIA Lung Study Respir. Res. (IF 5.8) Pub Date : 2024-03-11 Robert C. Wharton, Jing Gennie Wang, Yuni Choi, Elliot Eisenberg, Mariah K. Jackson, Corrine Hanson, Bian Liu, George R. Washko, Ravi Kalhan, David R. Jacobs, Sonali Bose
Lung function throughout adulthood predicts morbidity and mortality even among adults without chronic respiratory disease. Diet quality may represent a modifiable risk factor for lung function impairment later in life. We investigated associations between nutritionally-rich plant-centered diet and lung function across early and middle adulthood from the Coronary Artery Risk Development in Young Adults
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Cardiopulmonary exercise test to detect cardiac dysfunction from pulmonary vascular disease Respir. Res. (IF 5.8) Pub Date : 2024-03-11 Mona Alotaibi, Jenny Z. Yang, Demosthenes G. Papamatheakis, W. Cameron McGuire, Timothy M. Fernandes, Timothy A. Morris
Cardiac dysfunction from pulmonary vascular disease causes characteristic findings on cardiopulmonary exercise testing (CPET). We tested the accuracy of CPET for detecting inadequate stroke volume (SV) augmentation during exercise, a pivotal manifestation of cardiac limitation in patients with pulmonary vascular disease. We reviewed patients with suspected pulmonary vascular disease in whom CPET and
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Quercetin improves epithelial regeneration from airway basal cells of COPD patients Respir. Res. (IF 5.8) Pub Date : 2024-03-11 Elizabeth S. McCluskey, Nathan Liu, Abhimaneu Pandey, Nathaniel Marchetti, Steven G. Kelsen, Umadevi S. Sajjan
Airway basal cells (BC) from patients with chronic obstructive pulmonary disease (COPD) regenerate abnormal airway epithelium and this was associated with reduced expression of several genes involved in epithelial repair. Quercetin reduces airway epithelial remodeling and inflammation in COPD models, therefore we examined whether quercetin promotes normal epithelial regeneration from COPD BC by altering
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Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma Respir. Res. (IF 5.8) Pub Date : 2024-03-08 Runjin Cai, Xiaoxiao Gong, Xiaozhao Li, Yuanyuan Jiang, Shuanglinzi Deng, Jiale Tang, Huan Ge, Chendong Wu, Huan Tang, Guo Wang, Lei Xie, Xuemei Chen, Xinyue Hu, Juntao Feng
The pattern recognition receptor Dectin-1 was initially discovered to play a pivotal role in mediating pulmonary antifungal immunity and promoting neutrophil-driven inflammation. Recent studies have revealed that Dectin-1 is overexpressed in asthma, but the specific mechanism remains elusive. Additionally, Dectin-1 has been implicated in promoting pyroptosis, a hallmark of severe asthma airway inflammation
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Circulating miRNAs associate with historical childhood asthma hospitalization in different serum vitamin D groups Respir. Res. (IF 5.8) Pub Date : 2024-03-08 Xiaoning Hong, Mingye Jiang, Alvin T. Kho, Anshul Tiwari, Haiyan Guo, Alberta L. Wang, Michael J. McGeachie, Scott T. Weiss, Kelan G. Tantisira, Jiang Li
Vitamin D may help to alleviate asthma exacerbation because of its anti-inflammation effect, but the evidence is inconsistent in childhood asthma. MiRNAs are important mediators in asthma pathogenesis and also excellent non-invasive biomarkers. We hypothesized that circulating miRNAs are associated with asthma exacerbation and modified by vitamin D levels. We sequenced baseline serum miRNAs from 461
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MUC5AC concentrations in lung lavage fluids are associated with acute lung injury after cardiac surgery Respir. Res. (IF 5.8) Pub Date : 2024-03-07 Judith van Paassen, Pieter S. Hiemstra, Abraham C. van der Linden, Evert de Jonge, Jaap Jan Zwaginga, Robert J.M. Klautz, M. Sesmu Arbous
Heart surgery may be complicated by acute lung injury and adult respiratory distress syndrome. Expression and release of mucins MUC5AC and MUC5B in the lungs has been reported to be increased in acute lung injury. The aim of our study was to [1] investigate the perioperative changes of MUC5AC, MUC5B and other biomarkers in mini-bronchoalveolar lavage (minBAL), and [2] relate these to clinical outcomes
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Differences of respiratory mechanics in mechanical ventilation of acute respiratory distress syndrome between patients with COVID-19 and Influenza A Respir. Res. (IF 5.8) Pub Date : 2024-03-07 Eunki Chung, Ah Young Leem, Kyung Soo Chung, Young Ae Kang, Moo Suk Park, Young Sam Kim, Hye Jin Jang, Su Hwan Lee
Whether COVID-19-induced acute respiratory distress syndrome (ARDS) should be approached differently in terms of mechanical ventilation therapy compared to other virus-induced ARDS is debatable. Therefore, we aimed to ascertain whether the respiratory mechanical characteristics of COVID-19-induced ARDS differ from those of influenza A induced ARDS, in order to establish a rationale for mechanical ventilation
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Deciphering the molecular regulatory of RAB32/GPRC5A axis in chronic obstructive pulmonary disease Respir. Res. (IF 5.8) Pub Date : 2024-03-06 Yixing Wu, Binfeng He, Jianlan Hua, Weiping Hu, Yaopin Han, Jing Zhang
Chronic obstructive pulmonary disease (COPD) is a significant public health problem characterized by persistent airflow limitation. Despite previous research into the pathogenesis of COPD, a comprehensive understanding of the cell-type-specific mechanisms in COPD remains lacking. Recent studies have implicated Rab GTPases in regulating chronic immune response and inflammation via multiple pathways
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Association and mediation between educational attainment and respiratory diseases: a Mendelian randomization study Respir. Res. (IF 5.8) Pub Date : 2024-03-06 Guohui Lan, Mengying Xie, Jieli Lan, Zelin Huang, Xiaowei Xie, Mengdan Liang, Zhehui Chen, Xiannuan Jiang, Xiaoli Lu, Xiaoying Ye, Tingting Xu, Yiming Zeng, Xiaoxu Xie
Respiratory diseases are a major health burden, and educational inequalities may influence disease prevalence. We aim to evaluate the causal link between educational attainment and respiratory disease, and to determine the mediating influence of several known modifiable risk factors. We conducted a two-step, two-sample Mendelian randomization (MR) analysis using summary statistics from genome-wide
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Response to: are there over 200 distinct types of interstitial lung diseases? Respir. Res. (IF 5.8) Pub Date : 2024-03-06 Francesco Amati, Anna Stainer, Stefano Aliberti
We’d like to thank Cooley and Fernandez-Perez for their thoughtful comments and feedback on our article. The Authors underline that using standard classification schemes of interstitial lung disease (ILD) clinical diagnoses, the number of unique ILDs is far from exceeding 200. Moreover, the Authors noticed that this number is frequently reported in several papers. Depending on how you want to slice
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Disease trajectories in interstitial lung diseases – data from the EXCITING-ILD registry Respir. Res. (IF 5.8) Pub Date : 2024-03-06 Katharina Buschulte, Hans-Joachim Kabitz, Lars Hagmeyer, Peter Hammerl, Albert Esselmann, Conrad Wiederhold, Dirk Skowasch, Christoph Stolpe, Marcus Joest, Stefan Veitshans, Marc Höffgen, Phillen Maqhuzu, Larissa Schwarzkopf, Andreas Hellmann, Michael Pfeifer, Jürgen Behr, Rainer Karpavicius, Andreas Günther, Markus Polke, Philipp Höger, Vivien Somogyi, Christoph Lederer, Philipp Markart, Michael Kreuter
Interstitial lung diseases (ILD) comprise a heterogeneous group of mainly chronic lung diseases with different disease trajectories. Progression (PF-ILD) occurs in up to 50% of patients and is associated with increased mortality. The EXCITING-ILD (Exploring Clinical and Epidemiological Characteristics of Interstitial Lung Diseases) registry was analysed for disease trajectories in different ILD. The
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Self-administered at-home lung ultrasound with remote guidance in patients without clinical training Respir. Res. (IF 5.8) Pub Date : 2024-03-05 Nika Elmi, Yasmin Sadri, Frank Myslik, Jordan Chenkin, William Cherniak
Access to timely and accurate diagnostic imaging is essential for high-quality healthcare. Point-of-care ultrasound has been shown to be accessible and effective in many aspects of healthcare, including assessing changes in lung pathology. However, few studies have examined self-administered at-home lung ultrasound (SAAH-LUS), in particular performed by non-clinical patients (NCPs). Are NCPs able to
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Peroxiredoxin 3 has a crucial role in the macrophage polarization by regulating mitochondrial homeostasis Respir. Res. (IF 5.8) Pub Date : 2024-03-02 Wenhui Huang, Lianfang Wang, Zhipeng Huang, Zhichao Sun, Bojun Zheng
Acute lung injury (ALI) is one of the life-threatening complications of sepsis, and macrophage polarization plays a crucial role in the sepsis-associated ALI. However, the regulatory mechanisms of macrophage polarization in ALI and in the development of inflammation are largely unknown. In this study, we demonstrated that macrophage polarization occurs in sepsis-associated ALI and is accompanied by
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Prognosis of mechanically ventilated patients with COVID-19 after failure of high-flow nasal cannula: a retrospective cohort study Respir. Res. (IF 5.8) Pub Date : 2024-03-01 Dong-gon Hyun, Su Yeon Lee, Jee Hwan Ahn, Sang-Bum Hong, Chae-Man Lim, Younsuck Koh, Jin Won Huh
There is an argument whether the delayed intubation aggravate the respiratory failure in Acute respiratory distress syndrome (ARDS) patients with coronavirus disease 2019 (COVID-19). We aimed to investigate the effect of high-flow nasal cannula (HFNC) failure before mechanical ventilation on clinical outcomes in mechanically ventilated patients with COVID-19. This retrospective cohort study included
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FGF18 alleviates sepsis-induced acute lung injury by inhibiting the NF-κB pathway Respir. Res. (IF 5.8) Pub Date : 2024-02-28 Zhenyu Hu, Jindan Dai, Tianpeng Xu, Hui Chen, Guoxiu Shen, Jie Zhou, Hongfang Ma, Yang Wang, Litai Jin
Acute lung injury (ALI) is a devastating clinical disorder with a high mortality rate, and there is an urgent need for more effective therapies. Fibroblast growth factor 18 (FGF18) has potent anti-inflammatory properties and therefore has become a focus of research for the treatment of lung injury. However, the precise role of FGF18 in the pathological process of ALI and the underlying mechanisms have
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Immunomodulatory and clinical effects of receptor-interacting protein kinase 1 (RIPK1) inhibitor eclitasertib (SAR443122) in patients with severe COVID-19: a phase 1b, randomized, double-blinded, placebo-controlled study Respir. Res. (IF 5.8) Pub Date : 2024-02-28 Pierre-Francois Clot, Christine Farenc, Benjamin T. Suratt, Tillmann Krahnke, Agnes Tardat, Peter Florian, Robert Pomponio, Naimish Patel, Maria Wiekowski, Yong Lin, Benjamin Terrier, Heribert Staudinger
Targeting receptor-interacting serine/threonine protein kinase 1 could mitigate the devastating sequelae of the hyperinflammatory state observed in severe cases of COVID-19. This study explored the immunomodulatory and clinical effects of the receptor-interacting serine/threonine protein kinase 1 inhibitor SAR443122 (eclitasertib) in patients with severe COVID-19. In this Phase 1b, double-blinded,