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Application of bedside HINTS, ABCD2 score and truncal ataxia to differentiate cerebellar–brainstem stroke from vestibular neuritis in the emergency room Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-03-25 Xinmin Liu, Zhaoxia Li, Yi Ju, Xingquan Zhao
Background and purpose Acute vestibular syndrome (AVS) typically manifests as isolated dizziness or vertigo with no apparent neurological impairments. However, distinguishing life-threatening stroke from innocuous peripheral vestibular lesions in the emergency room (ER) remains challenging. This study aimed to explore the ability of the head impulse-nystagmus-test of skew (HINTS) combined with truncal
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TIMP1 protects against blood-brain barrier disruption after subarachnoid haemorrhage by inhibiting ubiquitination of astrocytic β1-integrin Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-03-14 Tianchi Tang, Huaijun Chen, Libin Hu, Jingya Ye, Chaohui Jing, Chaoran Xu, Xinyan Wu, Yike Chen, Zihang Chen, Hang Zhou, Linfeng Fan, Xiongjie Fu, Cong Qian, Jingsen Chen, Zhongju Tan, Jing Liu, Hanhai Zeng, Gao Chen, Fuyi Liu
Background Astrocytes regulate blood-brain barrier (BBB) integrity, whereas subarachnoid haemorrhage (SAH) results in astrocyte dysregulation and BBB disruption. Here, we explored the involvement of tissue inhibitor of matrix metalloprotease-1 (TIMP1) in astrocyte-mediated BBB protection during SAH, along with its underlying mechanisms. Methods C57BL/6J mice were used to establish a model of SAH. The
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Rationale and design of Treatment of Acute Ischaemic Stroke with Edaravone Dexborneol II (TASTE-2): a multicentre randomised controlled trial Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-03-11 Chunjuan Wang, Hong-Qiu Gu, Qiang Dong, Anding Xu, Ning Wang, Yi Yang, Feng Wang, Yongjun Wang
Background Edaravone dexborneol is believed to be a novel cytoprotective drug, demonstrating a synergistic combination of antioxidative and anti-inflammatory properties in animal models. The Treatment of Acute Ischaemic Stroke with Edaravone Dexborneol (TASTE) trial demonstrated its superior efficacy over edaravone alone for acute ischaemic stroke (AIS) patients. However, its efficacy in individuals
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Isolated anterior cerebral artery occlusion: an atypical form of moyamoya disease Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-03-09 Si-Meng Liu, Gan Gao, Fang-bin Hao, Shi-tong Liu, Ri-miao Yang, Hou-di Zhang, Min-Jie Wang, Zheng-xing Zou, Dan Yu, Qian Zhang, Qing-Bao Guo, Xiao-Peng Wang, He-guan Fu, Jing-Jie Li, Cong Han, Lian Duan
Background The relationship between anterior cerebral artery (ACA) occlusion and moyamoya disease (MMD) has rarely been studied. In this study, we focused on a special type of MMD: isolated ACA-occlusive MMD. We investigated clinical attributes, genotypes and progression risk factors in patients with ACA-occlusive MMD, providing initial insights into the relationship between ACA occlusion and MMD.
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Intracerebral haemorrhage in patients taking different types of oral anticoagulants: a pooled individual patient data analysis from two national stroke registries Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-02-08 Bernhard M Siepen, Elisabeth Forfang, Mattia Branca, Boudewijn Drop, Madlaine Mueller, Martina B Goeldlin, Mira Katan, Patrik Michel, Carlo Cereda, Friedrich Medlin, Nils Peters, Susanne Renaud, Julien Niederhauser, Emmanuel Carrera, Timo Kahles, Georg Kägi, Manuel Bolognese, Stephan Salmen, Marie-Luise Mono, Alexandros A Polymeris, Susanne Wegener, Werner Z'Graggen, Johannes Kaesmacher, Michael Schaerer
Background We investigated outcomes in patients with intracerebral haemorrhage (ICH) according to prior anticoagulation treatment with Vitamin K antagonists (VKAs), direct oral anticoagulants (DOACs) or no anticoagulation. Methods This is an individual patient data study combining two prospective national stroke registries from Switzerland and Norway (2013–2019). We included all consecutive patients
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Bilateral effect of acupuncture on cerebrum and cerebellum in ischaemic stroke patients with hemiparesis: a randomised clinical and neuroimaging trial Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-02-08 Tianzhu Chen, Tianyan Chen, Yong Zhang, Kang Wu, Yihuai Zou
Background Acupuncture involving the limb region may be effective for stroke rehabilitation clinically, but the visualised and explanatory evidence is limited. Our objectives were to assess the specific effects of acupuncture for ischaemic stroke (IS) patients with hemiparesis and investigate its therapy-driven modification in functional connectivity. Methods IS patients were randomly assigned (2:1)
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Prediction of futile recanalisation after endovascular treatment in acute ischaemic stroke: development and validation of a hybrid machine learning model Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-02-08 Ximing Nie, Jinxu Yang, Xinxin Li, Tianming Zhan, Dongdong Liu, Hongyi Yan, Yufei Wei, Xiran Liu, Jiaping Chen, Guoyang Gong, Zhenzhou Wu, Zhonghua Yang, Miao Wen, Weibin Gu, Yuesong Pan, Yong Jiang, Xia Meng, Tao Liu, Jian Cheng, Zixiao Li, Zhongrong Miao, Liping Liu
Background Identification of futile recanalisation following endovascular therapy (EVT) in patients with acute ischaemic stroke is both crucial and challenging. Here, we present a novel risk stratification system based on hybrid machine learning method for predicting futile recanalisation. Methods Hybrid machine learning models were developed to address six clinical scenarios within the EVT and perioperative
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Efficacy and safety of Y-2 sublingual tablet for patients with acute ischaemic stroke: protocol of a phase III randomised double-blind placebo-controlled multicentre trial Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-02-01 Yu Fu, Renhong Tang, Rong Chen, Anxin Wang, Jinsheng Ren, Shunwei Zhu, Xiaofei Feng, Dongsheng Fan
Background and purpose Clinical studies have demonstrated that edaravone dexborneol can improve the functional outcomes in patients with acute ischaemic stroke (AIS). The present clinical trial aimed at testing the efficacy and safety of Y-2 sublingual tablet on 90-day functional outcome in patients with AIS. Methods and design This is a randomised, double-blind, placebo-controlled, multicentre, parallel-group
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Prehospital transdermal glyceryl trinitrate for ultra-acute ischaemic stroke: data from the RIGHT-2 randomised sham-controlled ambulance trial Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-02-01 Jason Philip Appleton, Lisa J Woodhouse, Craig S Anderson, Sandeep Ankolekar, Lesley Cala, Mark Dixon, Timothy J England, Kailash Krishnan, Grant Mair, Keith W Muir, John Potter, Christopher I Price, Marc Randall, Thompson G Robinson, Christine Roffe, Else C Sandset, Jeffrey L Saver, Angela Shone, Aloysius Niroshan Siriwardena, Joanna M Wardlaw, Nikola Sprigg, Philip M Bath
Background The effect of transdermal glyceryl trinitrate (GTN, a nitrovasodilator) on clinical outcome when administered before hospital admission in suspected stroke patients is unclear. Here, we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaemic stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2).
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Early anticoagulation in patients with stroke and atrial fibrillation is associated with fewer ischaemic lesions at 1 month: the ATTUNE study Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-02-01 Angelos Sharobeam, Longting Lin, Christina Lam, Carlos Garcia-Esperon, Yash Gawarikar, Ronak Patel, Matthew Lee-Archer, Andrew Wong, Michael Roizman, Amanda Gilligan, Andrew Lee, Kee Meng Tan, Susan Day, Christopher Levi, Stephen M Davis, Mark Parsons, Bernard Yan
Background The optimal time to commence anticoagulation in patients with atrial fibrillation (AF) after ischaemic stroke or transient ischaemic attack (TIA) is unclear, with guidelines differing in recommendations. A limitation of previous studies is the focus on clinically overt stroke, rather than radiologically obvious diffusion-weighted imaging ischaemic lesions. We aimed to quantify silent ischaemic
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Rationale and design of Tenecteplase Reperfusion Therapy in Acute Ischaemic Cerebrovascular Events III (TRACE III): a randomised, phase III, open-label, controlled trial Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-02-01 Yunyun Xiong, Bruce C V Campbell, Marc Fisher, Lee H Schwamm, Mark Parsons, Hao Li, Yuesong Pan, Xia Meng, Xingquan Zhao, Yongjun Wang
Background and purpose Recombinant human TNK tissue-type plasminogen activator (rhTNK-tPA) was not inferior to alteplase for ischaemic stroke within 4.5 hours. Our study aimed to investigate the efficacy and safety of rhTNK-tPA in patients who had an ischaemic stroke due to large vessel occlusion (LVO) of anterior circulation beyond 4.5 hours. Methods and design Tenecteplase Reperfusion Therapy in
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Clinical features, treatment strategies and outcomes of craniocervical junction arteriovenous fistulas: a cohort study of 193 patients Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-02-01 Yongjie Ma, Zihao Song, Yinqing Wang, Jiachen Wang, Chuan He, Guilin Li, Peng Zhang, Tao Hong, Liyong Sun, Peng Hu, Ming Ye, Hongqi Zhang
Background Craniocervical junction (CCJ) arteriovenous fistulas (AVFs) are rare. The current treatment strategies for AVFs with different angioarchitecture need to be clarified. The present study aimed to analyse the correlation between angioarchitecture and clinical characteristics, share our experience in treating this disease and identify risk factors associated with subarachnoid haemorrhage (SAH)
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Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis (BASIS): protocol of a prospective, multicentre, randomised, controlled trial Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-02-01 Xuan Sun, Ming Yang, Dapeng Sun, Guangge Peng, Yiming Deng, Xingquan Zhao, Liping Liu, Ning Ma, Feng Gao, Dapeng Mo, Wengui Yu, Yongjun Wang, Yilong Wang, Zhongrong Miao
Background The superiority of balloon angioplasty plus aggressive medical management (AMM) to AMM alone for symptomatic intracranial artery stenosis (sICAS) on efficacy and safety profiles still lacks evidence from randomised controlled trials (RCTs). Aim To demonstrate the design of an RCT on balloon angioplasty plus AMM for sICAS. Design Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis
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Intra-arterial tenecteplase during thrombectomy for acute stroke (BRETIS-TNK II): rationale and design Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-02-01 Zi-Ai Zhao, Jing Qiu, Wei Li, Thanh Nguyen, Shouchun Wang, Huaizhang Shi, Ming Wei, Feng Wang, Di Li, Hui-Sheng Chen
Background Our recent pilot study suggests intra-arterial tenecteplase (TNK) during the first pass of endovascular treatment (EVT) seems safe, may increase first-pass reperfusion and good outcome in acute ischaemic stroke (AIS) patients with large-vessel occlusion (LVO). Aims To determine the efficacy and safety of intra-arterial TNK administration during EVT in AIS-LVO patients presenting up to 24
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Rationale and design of ProUrokinase in Mild IsChemic strokE (PUMICE): a multicentre, prospective, randomised, open-label, blinded-endpoint controlled trial Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-01-31 Yunyun Xiong, Manjun Hao, Yuesong Pan, Chunmiao Duan, Xueyan Feng, Hao Li, Na Wu, Liyuan Wang, Xia Meng, Xingquan Zhao, Yongjun Wang
Background and purpose Recombinant human prourokinase (rhPro-UK) is a new generation of specific plasminogen activator, that is non-inferior to alteplase in acute ischemic stroke. We aimed to investigate the efficacy and safety of rhPro-UK compared with standard medical treatment in acute mild ischemic stroke within 4.5 hours of symptom onset. Methods and design Prourokinase in mild ischemic stroke
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Intravenous tenecteplase compared with alteplase for minor ischaemic stroke: a secondary analysis of the AcT randomised clinical trial Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-01-31 Radhika Nair, Nishita Singh, Mahesh Kate, Negar Asdaghi, Robert Sarmiento, Fouzi Bala, Shelagh B Coutts, MacKenzie Horn, Alexandre Y Poppe, Heather Williams, Ayoola Ademola, Ibrahim Alhabli, Faysal Benali, Houman Khosravani, Gary Hunter, Aleksander Tkach, Herbert Alejandro Manosalva Alzate, Aleksandra Pikula, Thalia Field, Anurag Trivedi, Dar Dowlatshahi, Luciana Catanese, Ashfaq Shuaib, Andrew Demchuk
Background In ischaemic stroke, minor deficits (National Institutes of Health Stroke Scale (NIHSS) ≤5) at presentation are common but often progress, leaving patients with significant disability. We compared the efficacy and safety of intravenous thrombolysis with tenecteplase versus alteplase in patients who had a minor stroke enrolled in the Alteplase Compared to Tenecteplase in Patients With Acute
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Thrombolysis for ischaemic stroke despite direct oral anticoagulation Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-01-31 Jan C. Purrucker, Thomas R. Meinel, Duncan Wilson, Ying Xian, Teddy Y. Wu, David J. Seiffge
Intravenous thrombolysis is not recommended in anticoagulated patients receiving direct oral anticoagulants (DOACs) and a recent intake within the last 48 hours in US and European guidelines. However, three observational studies now suggest safety of thrombolysis in patients with recent intake of DOACs, and thus support previous experimental data. In this perspective, the current evidence and practical
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Risk stratification of delayed causative aneurysm detection and long-term outcome in angiographically negative spontaneous subarachnoid haemorrhage Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-01-31 Jie Wang, Jian-Feng Meng, Shuo Wang, Ji-Zong Zhao, Yong Cao
Background The risk factors of aetiology and poor outcome in angiographically negative subarachnoid haemorrhage (anSAH) were unclearly. Methods The authors performed a retrospective review of a prospectively maintained database for anSAH patients between 2014 and 2018. AnSAH was defined as SAH presents in CT with no underlying vascular abnormality on initial digital subtraction angiography (DSA) within
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Trendelenburg position for acute anterior circulation ischaemic stroke with large artery atherosclerosis aetiology (HOPES 3): rationale and design Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-01-31 Xiaoqiu Li, Zhenni Guo, Lu Wang, Yue Wang, Thanh Nguyen, Yi Yang, Hui-Sheng Chen
Rationale The effect of the head position as a non-pharmacological therapy on acute ischaemic stroke (AIS) remains inconclusive. Our recent Head dOwn-Position for acutE moderate ischaemic Stroke with large artery atherosclerosis (HOPES 2) suggested the safety, feasibility and potential benefit of the head-down position (HDP) in AIS. Aim To investigate the benefit of HDP in acute moderate ischaemic
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Gut Microbiome and Stroke: a Bidirectional Mendelian Randomisation Study in East Asian and European Populations Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-01-31 Shiyao Cheng, Hao Zheng, Yuandan Wei, Xingchen Lin, Yuqin Gu, Xinxin Guo, Zhe Fan, Hao Li, Si Cheng, Siyang Liu
Background and aims Observational studies have implicated the involvement of gut microbiome in stroke development. Conversely, stroke may disrupt the gut microbiome balance, potentially causing systemic infections exacerbated brain infarction. However, the causal relationship remains controversial or unknown. To investigate bidirectional causality and potential ethnic differences, we conducted a bidirectional
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Anti-stroke biologics: from recombinant proteins to stem cells and organoids Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-01-29 Zhu-Wei Miao, Zhi Wang, Si-Li Zheng, Shu-Na Wang, Chao-Yu Miao
The use of biologics in various diseases has dramatically increased in recent years. Stroke, a cerebrovascular disease, is the second most common cause of death, and the leading cause of disability with high morbidity worldwide. For biologics applied in the treatment of acute ischaemic stroke, alteplase is the only thrombolytic agent. Meanwhile, current clinical trials show that two recombinant proteins
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Discontinuation of antiplatelet therapy after stent-assisted coil embolisation of cerebral aneurysm: a nationwide cohort study Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-01-29 Minyoul Baik, Jimin Jeon, Jinkwon Kim, Joonsang Yoo
Introduction Stent-assisted coil embolisation (SACE) for the treatment of unruptured cerebral aneurysms has been increasingly used. Long-term advantages of antiplatelet therapy (APT) post-SACE treatment are still not well understood. We investigated the long-term effects of APT on clinical prognosis after SACE. Patients and methods We conducted a retrospective study using nationwide health insurance
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Reteplase versus alteplase for acute ischaemic stroke within 4.5 hours (RAISE): rationale and design of a multicentre, prospective, randomised, open-label, blinded-endpoint, controlled phase 3 non-inferiority trial Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-01-29 Shuya Li, Hong-Qiu Gu, Hongguo Dai, Guozhi Lu, Yongjun Wang
Background and purpose Reteplase is the third generation of alternative thrombolytic agent. We hypothesis that reteplase will be non-inferior to alteplase in achieving excellent functional outcome at 90 days among eligible patients with acute ischaemic stroke. Methods and design Reteplase versus alteplase for acute ischaemic stroke within 4.5 hours (RAISE) trial is a multicentre, prospective, randomised
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CSA declaration of next-generation reperfusion therapy for ischaemic stroke Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-01-17 Chinese Stroke Association
Cerebrovascular disease is a significant health concern that threatens people’s health and life. About 80% of its burden comes from ischaemic stroke. Early reperfusion therapy is the key to timely restore blood flow to salvageable ischaemic brain tissue. Reviewing the history of reperfusion therapy for ischaemic stroke, there have been two major breakthroughs: in 1995, following the publication of
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Low-intensity focused ultrasound stimulation promotes stroke recovery via astrocytic HMGB1 and CAMK2N1 in mice Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-01-08 Lin Qi, Cheng Wang, Lidong Deng, Jia-Ji Pan, Qian Suo, Shengju Wu, Lin Cai, Xudong Shi, Junfeng Sun, Yongting Wang, Yaohui Tang, Weibao Qiu, Guo-Yuan Yang, Jixian Wang, Zhijun Zhang
Background Low-intensity focused ultrasound stimulation (LIFUS) has been developed to enhance neurological repair and remodelling during the late acute stage of ischaemic stroke in rodents. However, the cellular and molecular mechanisms of neurological repair and remodelling after LIFUS in ischaemic stroke are unclear. Methods Ultrasound stimulation was treated in adult male mice 7 days after transient
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Real-world analysis of two ischaemic stroke and TIA systolic blood pressure goals on 12-month mortality and recurrent vascular events Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-01-08 Jason J Sico, Xin Hu, Laura J Myers, Deborah Levine, Dawn M Bravata, Greg W Arling
Introduction Whether obtaining the more intensive goal systolic blood pressure (SBP) of <130 mm Hg, rather than a less intensive SBP goal of <140 mm Hg poststroke/transient ischaemic attack (TIA) is associated with incremental mortality and recurrent vascular event benefit is largely unexplored using real-world data. Lowering SBP excessively may result in poorer outcomes. Methods This is a retrospective
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Safety and efficacy of glibenclamide on cerebral oedema following aneurysmal subarachnoid haemorrhage: a randomised, double-blind, placebo-controlled clinical trial Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2024-01-08 Xuebing Feng, Tongyu Zhang, Ning Wang, Xin Qu, Meng Qi, Hao Zhao, Hongqi Zhang, Yueqiao Xu
Background Glibenclamide has garnered attention due to its multifaceted neuroprotective effects in cases of acute central nervous system injury. We initiated a trial to explore the effectiveness and safety of a high dose of glibenclamide in the management of cerebral oedema following aneurysmal subarachnoid haemorrhage (aSAH). Methods This trial constituted a single-centre, randomised clinical study
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Real-world evaluation of Brainomix e-Stroke software Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-12-22 Dermot Mallon, Matthew Fallon, Eirini Blana, Cillian McNamara, Arathi Menon, Chak Lam Ip, Jack Garnham, Tarek Yousry, Peter Cowley, Robert Simister, David Doig
Background and purpose Brainomix e-Stroke is an artificial intelligence-based decision support tool that aids the interpretation of CT imaging in the context of acute stroke. While e-Stroke has the potential to improve the speed and accuracy of diagnosis, real-world validation is essential. The aim of this study was to prospectively evaluate the performance of Brainomix e-Stroke in an unselected cohort
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When treating acute ischaemic stroke of LVO type, time window prevails over tissue window Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-12-21 Xiaochuan Huo, Aoming Jin, Zhongrong Miao, Yongjun Wang, David Wang
Time is brain. How fast an occluded cerebral artery can be reopened is directly related to how many brain cells can be saved. The identification of a tissue window as indicated by the presence of a penumbra on multimodality imaging study has opened the time window of treatment to 24 hours after the onset.1 From 2019 to 2022, the issue of direct intra-arterial (IA) mechanical thrombectomy (MT) is non-inferior
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Treatment practice of vasospasm during endovascular thrombectomy: an international survey Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-12-19 Jessica Jesser, Thanh Nguyen, Adam A Dmytriw, Hiroshi Yamagami, Zhongrong Miao, Louisa Johanna Sommer, Andrea Stockero, Johannes Alex Rolf Pfaff, Johanna Ospel, Mayank Goyal, Aman B Patel, Vitor Mendes Pereira, Uta Hanning, Lukas Meyer, Wim H van Zwam, Martin Bendszus, Martin Wiesmann, Markus Möhlenbruch, Charlotte Sabine Weyland
Background and aim The clinical importance and management of vasospasm as a complication during endovascular stroke treatment (EVT) has not been well studied. We sought to investigate current expert opinions in neurointervention and therapeutic strategies of iatrogenic vasospasm during EVT. Methods We conducted an anonymous international online survey (4 April 2023 to 15 May 2023) addressing treatment
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Prestroke physical activity is associated with admission haematoma volume and the clinical outcome of intracerebral haemorrhage Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-12-01 Adam Viktorisson, Dongni Buvarp, Anna Danielsson, Thomas Skoglund, Katharina S Sunnerhagen
Background Prestroke physical activity (PA) has been linked to improved outcomes after intracerebral haemorrhage (ICH), but its association with ICH volume is unknown. We aimed to investigate associations of prestroke PA with location-specific haematoma volume and the clinical outcome of ICH. Methods All patients with primary ICH, admitted to three hospitals between 2014 and 2019, were included. Patients
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Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia/macrophages Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-12-01 Ruiyi Zhang, Yifei Dong, Yang Liu, Dorsa Moezzi, Samira Ghorbani, Reza Mirzaei, Brian M Lozinski, Jeff F Dunn, V Wee Yong, Mengzhou Xue
Background Inflammation-exacerbated secondary brain injury and limited tissue regeneration are barriers to favourable prognosis after intracerebral haemorrhage (ICH). As a regulator of inflammation and lipid metabolism, Liver X receptor (LXR) has the potential to alter microglia/macrophage (M/M) phenotype, and assist tissue repair by promoting cholesterol efflux and recycling from phagocytes. To support
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Development of machine learning-based models to predict 10-year risk of cardiovascular disease: a prospective cohort study Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-12-01 Jia You, Yu Guo, Ju-Jiao Kang, Hui-Fu Wang, Ming Yang, Jian-Feng Feng, Jin-Tai Yu, Wei Cheng
Background Previous prediction algorithms for cardiovascular diseases (CVD) were established using risk factors retrieved largely based on empirical clinical knowledge. This study sought to identify predictors among a comprehensive variable space, and then employ machine learning (ML) algorithms to develop a novel CVD risk prediction model. Methods From a longitudinal population-based cohort of UK
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Preclinical evaluation of ZL006-05, a new antistroke drug with fast-onset antidepressant and anxiolytic effects Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-12-01 Haiyin Wu, Zhenquan Huang, Xuan Wang, Mingyu Chen, Wei Chen, Yao Hua, Jian Ren, Luyao Shen, Yixuan Song, Ying Zhou, Chunxia Luo, Yuhui Lin, Yilong Wang, Lei Chang, Fei Li, Dongya Zhu
Background Poststroke depression and anxiety, independent predictor of poor functional outcomes, are common in the acute phase of stroke. Up to now, there is no fast-onset antidepressive and anxiolytic agents suitable for the management of acute stroke. ZL006-05, a dual-target analgesic we developed, dissociates nitric oxide synthase from postsynaptic density-95 while potentiates α2-containing γ-aminobutyric
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Photochemically induced thalamus infarction impairs cognition in a mouse model Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-12-01 Chen Zhang, Shiping Li, Yongjun Wang, Jiong Shi
Background Small subcortical infarcts account for up to 25% of ischaemic strokes. Thalamus is one of the subcortical structures that commonly manifest with lacunar infarcts on MRI of the brain. Studies have shown that thalamus infarction is associated with cognitive decline. However, due to the lack of proper animal models, little is known about the mechanism. We aimed to establish a focal thalamus
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Cerebral haemodynamics in symptomatic intracranial atherosclerotic disease: a narrative review of the assessment methods and clinical implications Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-12-01 Yuying Liu, Shuang Li, Xuan Tian, Thomas W Leung, Liping Liu, David S Liebeskind, Xinyi Leng
Intracranial atherosclerotic disease (ICAD) is a common cause of ischaemic stroke and transient ischaemic attack (TIA) with a high recurrence rate. It is often referred to as intracranial atherosclerotic stenosis (ICAS), when the plaque has caused significant narrowing of the vessel lumen. The lesion is usually considered ‘symptomatic ICAD/ICAS’ (sICAD/sICAS) when it has caused an ischaemic stroke
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Somatic GJA4 mutation in intracranial extra-axial cavernous hemangiomas Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-12-01 Ran Huo, Yingxi Yang, Hongyuan Xu, Shaozhi Zhao, Dong Song, Jiancong Weng, Ruochen Ma, Yingfan Sun, Jie Wang, Yuming Jiao, Junze Zhang, Qiheng He, Ruolei Wu, Shuo Wang, Ji-Zong Zhao, Junting Zhang, Jiguang Wang, Yong Cao
Objective Extra-axial cavernous hemangiomas (ECHs) are sporadic and rare intracranial occupational lesions that usually occur within the cavernous sinus. The aetiology of ECHs remains unknown. Methods Whole-exome sequencing was performed on ECH lesions from 12 patients (discovery cohort) and droplet digital polymerase-chain-reaction (ddPCR) was used to confirm the identified mutation in 46 additional
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Association between Life’s Essential 8 and Cerebral Small Vessel Disease Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-11-20 Dandan Liu, Xueli Cai, Yingying Yang, Suying Wang, Lerong Mei, Jing Jing, Shan Li, Mengxing Wang, Yun Chen, Xia Meng, Tiemin Wei, Yongjun Wang, Yilong Wang, Yuesong Pan
Background Given that associations of Life’s Essential 8 (LE8) and cerebral small vessel disease (CSVD) or its imaging markers were unclear, we examined relationship between them. Methods The cross-sectional study included community residents from the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events study. We calculated the total LE8 score, medical LE8 score and behavioural score
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Association between Life’s Essential 8 and Cerebral Small Vessel Disease Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-11-20 Dandan Liu, Xueli Cai, Yingying Yang, Suying Wang, Lerong Mei, Jing Jing, Shan Li, Mengxing Wang, Yun Chen, Xia Meng, Tiemin Wei, Yongjun Wang, Yilong Wang, Yuesong Pan
Background Given that associations of Life’s Essential 8 (LE8) and cerebral small vessel disease (CSVD) or its imaging markers were unclear, we examined relationship between them. Methods The cross-sectional study included community residents from the PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events study. We calculated the total LE8 score, medical LE8 score and behavioural score
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Cerebral small vessel disease modifies outcomes after minimally invasive surgery for intracerebral haemorrhage Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-11-10 Yunke Li, Sung-Min Cho, Radhika Avadhani, Hassan Ali, Yi Hao, Santosh B Murthy, Joshua N Goldstein, Fan Xia, Xin Hu, Natalie L Ullman, Issam Awad, Daniel Hanley, Wendy C Ziai
Background Minimally invasive surgery (MIS) for spontaneous supratentorial intracerebral haemorrhage (ICH) is controversial but may be beneficial if end-of-treatment (EOT) haematoma volume is reduced to ≤15 mL. We explored whether MRI findings of cerebral small vessel disease (CSVD) modify the effect of MIS on long-term outcomes. Methods Prespecified blinded subgroup analysis of 288 subjects with qualified
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Surgical timing and long-term outcomes in patients with severe haemorrhagic spinal cord cavernous malformations Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-11-10 An Tian, Ziwei Cui, Jian Ren, Yeqing Ren, Ming Ye, Guilin Li, Chuan He, Xiaoyu Li, Gao Zeng, Peng Hu, Yongjie Ma, Jiaxing Yu, Jingwei Li, Lisong Bian, Fan Yang, Qianwen Li, Feng Ling, Tao Hong, Liyong Sun, Hongqi Zhang
Background Surgical resection of the lesions remains the main treatment method for most symptomatic spinal cord cavernous malformations (SCCMs) to eliminate the occupation and associated subsequent lifelong haemorrhagic risk. However, the timing of surgical intervention remains controversial, especially for patients in the acute stage after severe haemorrhage. Methods Patients diagnosed with SCCMs
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Combined effect of cortical superficial siderosis and cerebral microbleed on short-term and long-term outcomes after intracerebral haemorrhage Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-11-10 Yujia Jin, Yu-hui Huang, Yu-ping Chen, Yao-dan Zhang, Jiawen Li, Kai-cheng Yang, Xianghua Ye, Lu-hang Jin, Jian Wu, Chang-zheng Yuan, Feng Gao, Lu-sha Tong
Background and purpose Cortical superficial siderosis (cSS) and cerebral microbleed (CMB) have distinct effects on intracerebral haemorrhage (ICH). We aim to investigate the combined effect of cSS and CMB on outcomes after ICH. Methods Based on a single-centre stroke registry database, patients with spontaneous ICH who had CT scan within 48 hours after ictus and MRI subsequently were identified. Eligible
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Cerebral small vessel disease modifies outcomes after minimally invasive surgery for intracerebral haemorrhage Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-11-10 Yunke Li, Sung-Min Cho, Radhika Avadhani, Hassan Ali, Yi Hao, Santosh B Murthy, Joshua N Goldstein, Fan Xia, Xin Hu, Natalie L Ullman, Issam Awad, Daniel Hanley, Wendy C Ziai
Background Minimally invasive surgery (MIS) for spontaneous supratentorial intracerebral haemorrhage (ICH) is controversial but may be beneficial if end-of-treatment (EOT) haematoma volume is reduced to ≤15 mL. We explored whether MRI findings of cerebral small vessel disease (CSVD) modify the effect of MIS on long-term outcomes. Methods Prespecified blinded subgroup analysis of 288 subjects with qualified
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Surgical timing and long-term outcomes in patients with severe haemorrhagic spinal cord cavernous malformations Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-11-10 An Tian, Ziwei Cui, Jian Ren, Yeqing Ren, Ming Ye, Guilin Li, Chuan He, Xiaoyu Li, Gao Zeng, Peng Hu, Yongjie Ma, Jiaxing Yu, Jingwei Li, Lisong Bian, Fan Yang, Qianwen Li, Feng Ling, Tao Hong, Liyong Sun, Hongqi Zhang
Background Surgical resection of the lesions remains the main treatment method for most symptomatic spinal cord cavernous malformations (SCCMs) to eliminate the occupation and associated subsequent lifelong haemorrhagic risk. However, the timing of surgical intervention remains controversial, especially for patients in the acute stage after severe haemorrhage. Methods Patients diagnosed with SCCMs
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Combined effect of cortical superficial siderosis and cerebral microbleed on short-term and long-term outcomes after intracerebral haemorrhage Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-11-10 Yujia Jin, Yu-hui Huang, Yu-ping Chen, Yao-dan Zhang, Jiawen Li, Kai-cheng Yang, Xianghua Ye, Lu-hang Jin, Jian Wu, Chang-zheng Yuan, Feng Gao, Lu-sha Tong
Background and purpose Cortical superficial siderosis (cSS) and cerebral microbleed (CMB) have distinct effects on intracerebral haemorrhage (ICH). We aim to investigate the combined effect of cSS and CMB on outcomes after ICH. Methods Based on a single-centre stroke registry database, patients with spontaneous ICH who had CT scan within 48 hours after ictus and MRI subsequently were identified. Eligible
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Time to treat the climate and nature crisis as one indivisible global health emergency Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-25 Chris Zielinski
Over 200 health journals call on the United Nations (UN), political leaders and health professionals to recognise that climate change and biodiversity loss are one indivisible crisis and must be tackled together to preserve health and avoid catastrophe. This overall environmental crisis is now so severe as to be a global health emergency. The world is currently responding to the climate crisis and
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Time to treat the climate and nature crisis as one indivisible global health emergency Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-25 Chris Zielinski
Over 200 health journals call on the United Nations (UN), political leaders and health professionals to recognise that climate change and biodiversity loss are one indivisible crisis and must be tackled together to preserve health and avoid catastrophe. This overall environmental crisis is now so severe as to be a global health emergency. The world is currently responding to the climate crisis and
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Longitudinal associations of cardiovascular health and vascular events with incident dementia Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-21 Ya-Nan Ou, Kevin Kuo, Liu Yang, Ya-Ru Zhang, Shu-Yi Huang, Shi-Dong Chen, Yue-Ting Deng, Yu Guo, Rui-Qi Zhang, Bang-Sheng Wu, Lan Tan, Qiang Dong, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Introduction Evidence supporting cardiovascular diseases could increase the risk of dementia remains fragmented. A comprehensive study to illuminate the distinctive associations across different dementia types is still lacking. This study is sought to: (1) determine the clinical validity of Framingham General Cardiovascular Risk Score (FGCRS) for dementia assessment and (2) examine the associations
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Longitudinal associations of cardiovascular health and vascular events with incident dementia Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-21 Ya-Nan Ou, Kevin Kuo, Liu Yang, Ya-Ru Zhang, Shu-Yi Huang, Shi-Dong Chen, Yue-Ting Deng, Yu Guo, Rui-Qi Zhang, Bang-Sheng Wu, Lan Tan, Qiang Dong, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Introduction Evidence supporting cardiovascular diseases could increase the risk of dementia remains fragmented. A comprehensive study to illuminate the distinctive associations across different dementia types is still lacking. This study is sought to: (1) determine the clinical validity of Framingham General Cardiovascular Risk Score (FGCRS) for dementia assessment and (2) examine the associations
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Incidence and predictors of futile recanalisation after endovascular therapy in acute vertebrobasilar artery occlusion patients: insight from the ANGEL-ACT registry Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-12 Dapeng Sun, Xinguang Yang, Xiaochuan Huo, Raynald, Baixue Jia, Xu Tong, Anxin Wang, Ning Ma, Feng Gao, Dapeng Mo, Zhongrong Miao
Objectives To identify the occurrence rate and predictors of futile recanalisation after endovascular therapy (EVT) for acute vertebrobasilar artery occlusion (VBAO). Methods Participants of the Endovascular Treatment Key Technique and Emergency Workflow Improvement of Acute Ischaemic Stroke (ANGEL-ACT) registry were selected for the analysis. Futile recanalisation was defined as patients did not achieve
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Reperfusion and cytoprotective agents are a mutually beneficial pair in ischaemic stroke therapy: an overview of pathophysiology, pharmacological targets and candidate drugs focusing on excitotoxicity and free radical Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-13 Xiumei Xu, Mingyu Chen, Dongya Zhu
Stroke is the second-leading cause of death and the leading cause of disability in much of the world. In particular, China faces the greatest challenge from stroke, since the population is aged quickly. In decades of clinical trials, no neuroprotectant has had reproducible efficacy on primary clinical end points, because reperfusion is probably a necessity for neuroprotection to be clinically beneficial
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Incidence and predictors of futile recanalisation after endovascular therapy in acute vertebrobasilar artery occlusion patients: insight from the ANGEL-ACT registry Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-12 Dapeng Sun, Xinguang Yang, Xiaochuan Huo, Raynald, Baixue Jia, Xu Tong, Anxin Wang, Ning Ma, Feng Gao, Dapeng Mo, Zhongrong Miao
Objectives To identify the occurrence rate and predictors of futile recanalisation after endovascular therapy (EVT) for acute vertebrobasilar artery occlusion (VBAO). Methods Participants of the Endovascular Treatment Key Technique and Emergency Workflow Improvement of Acute Ischaemic Stroke (ANGEL-ACT) registry were selected for the analysis. Futile recanalisation was defined as patients did not achieve
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Is intraprocedural intravenous aspirin safe for patients who require emergent extracranial stenting during mechanical thrombectomy? Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-06 Adam Ingleton, Marko Raseta, Rui-En Chung, Kevin Jun Hui Kow, Jake Weddell, Sanjeev Nayak, Changez Jadun, Zafar Hashim, Noman Qayyum, Phillip Ferdinand, Indira Natarajan, Christine Roffe
Background Intraoperative antiplatelet therapy is recommended for emergent stenting during mechanical thrombectomy (MT). Most patients undergoing MT are also given thrombolysis. Antiplatelet agents are contraindicated within 24 hours of thrombolysis. We evaluated outcomes and complications of patients stented with and without intravenous aspirin during MT. Methods All patients who underwent emergent
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Is intraprocedural intravenous aspirin safe for patients who require emergent extracranial stenting during mechanical thrombectomy? Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-06 Adam Ingleton, Marko Raseta, Rui-En Chung, Kevin Jun Hui Kow, Jake Weddell, Sanjeev Nayak, Changez Jadun, Zafar Hashim, Noman Qayyum, Phillip Ferdinand, Indira Natarajan, Christine Roffe
Background Intraoperative antiplatelet therapy is recommended for emergent stenting during mechanical thrombectomy (MT). Most patients undergoing MT are also given thrombolysis. Antiplatelet agents are contraindicated within 24 hours of thrombolysis. We evaluated outcomes and complications of patients stented with and without intravenous aspirin during MT. Methods All patients who underwent emergent
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Src inhibition rescues FUNDC1-mediated neuronal mitophagy in ischaemic stroke Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-04 Tianchi Tang, Li-bin Hu, Chao Ding, Zhihua Zhang, Ning Wang, Tingting Wang, Hang Zhou, Siqi Xia, Linfeng Fan, Xiong-jie Fu, Feng Yan, Xiangnan Zhang, Gao Chen, Jianru Li
Background Ischaemic stroke triggers neuronal mitophagy, while the involvement of mitophagy receptors in ischaemia/reperfusion (I/R) injury-induced neuronal mitophagy remain not fully elucidated. Here, we aimed to investigate the involvement of mitophagy receptor FUN14 domain-containing 1 (FUNDC1) and its modulation in neuronal mitophagy induced by I/R injury. Methods Wild-type and FUNDC1 knockout
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Stroke depression: a concept with clinical applicability Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-04 Jun Mu, Arun V Ravindran, Pim Cuijpers, Yiqing Shen, Wensong Yang, Qi Li, Xinyu Zhou, Peng Xie
Stroke is a common neurological condition and among the leading causes of death and disability worldwide. Depression is both a risk factor for and complication of stroke, and the two conditions may have a complex reciprocal relationship over time. However, the secondary effects of depression on stroke are often overlooked, resulting in increased morbidity and mortality. In the previous concept of ‘poststroke
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Retinal artery/arteriole occlusion risks after endovascular treatment for unruptured intracranial aneurysm Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-04 Hae Rang Kim, Min Jeoung Kim, Sunyeup Kim, Myung Soo Chang, Dong Joon Kim, Byung Moon Kim, Keun Young Park, Yong Bae Kim, Christopher Seungkyu Lee, Suk Ho Byeon, Sung Soo Kim, Seung Won Lee, Yong Joon Kim
Background To evaluate the association between retinal artery/arteriole occlusion (RAO) and unruptured intracranial aneurysm (UIA). Methods Incident UIA patients from a nationwide cohort (n=253 240) were categorised into three groups based on subsequent treatment: observation (n=208 993), microsurgical clipping (n=14 168) and endovascular treatment (EVT) groups (n=30 079). The incidence and the incident
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Src inhibition rescues FUNDC1-mediated neuronal mitophagy in ischaemic stroke Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-04 Tianchi Tang, Li-bin Hu, Chao Ding, Zhihua Zhang, Ning Wang, Tingting Wang, Hang Zhou, Siqi Xia, Linfeng Fan, Xiong-jie Fu, Feng Yan, Xiangnan Zhang, Gao Chen, Jianru Li
Background Ischaemic stroke triggers neuronal mitophagy, while the involvement of mitophagy receptors in ischaemia/reperfusion (I/R) injury-induced neuronal mitophagy remain not fully elucidated. Here, we aimed to investigate the involvement of mitophagy receptor FUN14 domain-containing 1 (FUNDC1) and its modulation in neuronal mitophagy induced by I/R injury. Methods Wild-type and FUNDC1 knockout
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Stroke depression: a concept with clinical applicability Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-04 Jun Mu, Arun V Ravindran, Pim Cuijpers, Yiqing Shen, Wensong Yang, Qi Li, Xinyu Zhou, Peng Xie
Stroke is a common neurological condition and among the leading causes of death and disability worldwide. Depression is both a risk factor for and complication of stroke, and the two conditions may have a complex reciprocal relationship over time. However, the secondary effects of depression on stroke are often overlooked, resulting in increased morbidity and mortality. In the previous concept of ‘poststroke
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Retinal artery/arteriole occlusion risks after endovascular treatment for unruptured intracranial aneurysm Stroke Vasc. Neurol. (IF 5.9) Pub Date : 2023-10-04 Hae Rang Kim, Min Jeoung Kim, Sunyeup Kim, Myung Soo Chang, Dong Joon Kim, Byung Moon Kim, Keun Young Park, Yong Bae Kim, Christopher Seungkyu Lee, Suk Ho Byeon, Sung Soo Kim, Seung Won Lee, Yong Joon Kim
Background To evaluate the association between retinal artery/arteriole occlusion (RAO) and unruptured intracranial aneurysm (UIA). Methods Incident UIA patients from a nationwide cohort (n=253 240) were categorised into three groups based on subsequent treatment: observation (n=208 993), microsurgical clipping (n=14 168) and endovascular treatment (EVT) groups (n=30 079). The incidence and the incident