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Blood rheology and vascular function in sickle cell trait and sickle cell disease: From pathophysiological mechanisms to clinical usefulness Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2024-02-22 Philippe Connes
Sickle cell disease (SCD) is an autosomal recessive disorder. Although the molecular mechanisms at the origin of SCD have been well characterized, its clinical expression is highly variable. SCD is characterized by blood rheological abnormalities, increased inflammation and oxidative stress, and vascular dysfunction. Individuals with only one copy of the mutated β-globin gene have sickle cell trait
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History of the cutaneous microcirculation from antiquity to modern times Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2024-02-22 F. Jung
This review spans a wide arc from the first observations of the early anatomists to the present day. William Harvey was the first to describe the heart as the centre of the large and small circulatory system. He thus replaced the previously valid system of Galenos, It was Marcello Malpighi who first described that the capillary system connects the arteries with the veins. In 1688 Antoni van Leeuwenhoek
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Hepatic steatosis using ultrasound-derived fat fraction: First technical and clinical evaluation Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2024-02-22 Yun-Lin Huang, Juan Cheng, Ying Wang, Xin-Liang Xu, Shi-Wen Wang, Li Wei, Yi Dong
OBJECTIVES: To explore the technical and clinical evaluation of ultrasound-derived fat fraction (UDFF) measurement in adult patients in whom fatty liver was suspected. MATERIALS AND METHODS: In this prospective study, 41 participants were initially enrolled in our hospital between October 2022 andDecember 2022 and received UDFF assessment using Siemens ACUSON Sequoia system equipped with DAX transducer
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Free neurovascular toe-(joint)-transfers compared to alternative reconstructive procedures for amputation injuries of two and tripartite fingers with substance loss Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2024-02-22 E. Brix, L. Prantl, A. Anker, S. Klein, A. Kehrer
BACKGROUND:Complex injuries of the hand frequently result in loss of essential functional features. Common reconstructive procedures for soft tissue defects of the thumb or phalanges are locoregional flaps like Moberg-, Foucher-, Cross-Finger- or Littler flaps. Microneurovascular toe (joint-) transfers complete the arsenal of operative reconstructive procedures and allow for most detailed reconstructions
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Initial description of the novel handheld wireless ultrasound device TE Air with Doppler and Color Duplex imaging Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2024-02-22 Ernst Michael Jung, Friedrich Jung, Yi Dong, Ulrich Kaiser
Abstract OBJECTIVE: To test and initially describe a new handheld wireless ultrasound technique (TE Air) for clinical use. METHODS: In this pilot study, the new ultrasound device TE Air from Mindray was used to examine the hepatic and renal vessels of healthy volunteers for first impressions. The probe has a sector transducer with a frequency range of 1.8–4.5 MHz. The B-mode and color-coded doppler
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The shear rate promotes pinocytosis of extracellular dextran in platelets Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2024-02-20 Masataka Inoue, Masahiro Ohwada, Nobuo Watanabe
Abstract BACKGROUND: Several conventional studies focused on platelet pinocytosis for possible utilization as drug delivery systems. Although platelet pinocytosis is important in such utilization, the impact of the shear rate on pinocytosis is unclear. OBJECTIVE: Our objective was to investigate the relationship between shear rate and platelet pinocytosis in vitro. In addition, this study addressed
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Multimodal ultrasonic manifestations of secretory carcinoma of the breast: A case description Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2024-02-20 Zehong Wu, Manli Liao, Huajuan Li, Shengchao Huang, Xin Liang, Bohan Chen, Guoli Zhang, Yuping Yang, Xiaohong Xu
Secretory carcinoma of the breast (SCB) is a rare and specific type of breast cancer. Owing to its rarity, the number of SCB reports available is limited, with most of them focusing on clinical and pathological characteristics but no reports on its multimodal ultrasound (US) features. Thus, we present a rare case of SCB, retrospectively analyzing manifestations of US and contrast-enhanced US, as well
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Sonographic methods to predict type 2 diabetes patients with sarcopenia: B mode ultrasound and shear wave elastography Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2024-02-16 Shengqiao Wang, Xinliang Xu, Siqi Cao, Juan Cheng, Ying Wang, Yi Dong
BACKGROUND:Type 2 diabetes accelerates the loss of muscle mass and strength. Sarcopenia is also one of the chronic complications of diabetes. OBJECTIVE:To investigate the clinical value of B mode ultrasound (BMUS) and shear wave elastography (SWE) for predicting type 2 diabetic sarcopenia. METHODS:We recorded Skeletal Muscle Mass Index (ASMI), grip strength, muscle thickness (MT), pinna angle (PA)
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Perfluorobutane application value in microwave ablation of Small Hepatocellular Carcinoma (<3 cm) Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2024-01-24 Yanghong Pan, Delin Liu, Fei Liang, Zixiang Kong, Xu Zhang, Qinqin Ai
BACKGROUND:No studies have been retrieved comparing perfluorobutane with sulfur hexafluoride for microwave ablation (MWA) in small hepatocellular carcinoma(sHCC). OBJECTIVE:To retrospective investigate the value of perfluorobutane ultrasonography contrast agent in ultrasonography (US)-guided MWA ofsHCC. METHODS:We conducted a retrospective clinical controlled study about US-guided percutaneous MWA
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Circ_CHMP5 aggravates oxidized low-density lipoprotein-induced damage to human umbilical vein endothelial cells through miR-516b-5p/TGFβR2 axis Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-12-27 Yueru Wang, Ping Liu, Xiaoyan Chen, Wuxiao Yang
BACKGROUND: Atherosclerosis (AS) was one of the main causes of death in the elderly, and lesions in human umbilical vein endothelial cells (HUVECs) could lead to AS. CircRNA-charged multivesicular body protein 5 (circ_CHMP5) was reported to participate in the progression of AS. METHODS: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to analyze the levels of circ_CHMP5, miR-516b-5p
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Dynamic contrast-enhanced ultrasound characteristics of renal tumors: VueBox™ quantitative analysis Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-12-27 Ning Li, Ziyue Hu, Yang Liu, Jianmin Ding, Pengcheng Han, Xiang Jing, Yanmin Kan
BACKGROUND:VueBoxtrademark has been used for contrast analysis in DCE-US-based quantitative research. OBJECTIVE:Aim of this study was to use the enhancement-mode and VueBoxtrademark parameters to further evaluate the differential diagnostic value of DCE-US for renal tumors. METHODS:24 patients withrenal tumors, including 7 benign and 17 malignant, were retrospectively analyzed.The DCE-US enhancement-mode
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CircRBM33 induces endothelial dysfunction by targeting the miR-6838-5p/PDCD4 axis affecting blood-brain barrier in mice with cerebral ischemia-reperfusion injury Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-12-27 Yanbin Zhang, Xiaodong Yuan, Jie Xu, Huafen Gu
BACKGROUND:circRNAs (circRNAs) are involved in the process of cerebral ischemia-reperfusion injury (CI/RI). Our study aims to explore circRBM33 in the endothelial function of the blood-brain barrier (BBB). METHODS:The mouse middle cerebral artery occlusion model (MCAO) was established and restoredto perfusion, and OGD/R-induced endothelial cells were used to simulate CI/RI. circRBM33, miR-6838-5p and
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Blood-based protein biomarkers and red blood cell aggregation in pancreatic cancer Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-12-27 Maciej Wiewiora, Janusz Jopek, Elżbieta Świętochowska, Gregorczyn Sławomir, Jerzy Piecuch Jr., Mateusz Gąska, Jerzy Piecuch
BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is highly malignant with a low 5-year survival rate. Blood biomarkers may be of value for the noninvasive diagnosis of pancreatic cancer. OBJECTIVE:This study assessed blood-based biomarkers and disturbances in red blood cell aggregation associatedwith pancreatic cancer. METHODS:We studied 61 patients who underwent pancreatic resection. Of these 61
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Effectiveness of an online/offline mixed-mode Tai Chi cardiac rehabilitation program on microcirculation in patients with coronary artery disease: A randomized controlled study Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-12-27 Shaojun Lyu, Zaihao Chen, Meize Cui, Qiuyang Wei, Yameng Li, Hui Fang, Mingyu Liu, Linli Liu, Jiahao Fu, Jianwei Zhang
OBJECTIVE:We explored the effectiveness of an online/offline mixed-mode Tai Chi cardiac rehabilitation program on the microcirculation of patients with coronary artery disease (CAD). DESIGN:Prospective, randomized controlled study. SETTING:It was conducted in a tertiary hospital. SUBJECTS:Twenty-six patients who met the diagnostic criteria for coronary artery disease were recruited. INTERVENTIONS:Patients
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Comparison of the diagnostic performance of three ultrasound thyroid nodule risk stratification systems for follicular thyroid neoplasm: K-TIRADS, ACR -TIRADS and C-TIRADS Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-12-27 Hua-Juan Li, Yu-Ping Yang, Xin Liang, Zhi Zhang, Xiao-Hong Xu
OBJECTIVE:To explore the diagnostic performance of the currently used ultrasound-based thyroid nodule risk stratification systems (K-TIRADS, ACR -TIRADS, and C-TIRADS) in differentiating follicular thyroid adenoma (FTA) from follicular thyroid carcinoma (FTC). METHODS:Clinical data and preoperativeultrasonographic images of 269 follicular thyroid neoplasms were retrospectively analyzed. All of them
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Predicting glypican-3 expression in hepatocellular carcinoma: A comprehensive analysis using combined contrast-enhanced ultrasound and clinical factors Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-12-27 Nana Li, Tiantian Dong, Peihua Wang, Qi Li, Fang Nie
OBJECTIVE: Glypican-3 (GPC3) has emerged as a significant marker for the diagnosis and prognosis of hepatocellular carcinoma (HCC) and has garnered considerable attention as an immunotherapeutic target. In this study, we propose a combination of preoperative contrast-enhanced ultrasound (CEUS) imaging features and clinical factors to predict the positive expression of GPC3 in HCC patients. METHODS:
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Differential diagnosis between pancreatic solid pseudopapillary tumors and pancreatic neuroendocrine tumors based on contrast enhanced ultrasound imaging features Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-12-27 Qi Zhang, Yi-Jie Qiu, Dao-Hui Yang, Xiu-Yun Lu, Sheng Chen, Yi Dong, Wen-Ping Wang
PURPOSES:To evaluate the application of contrast enhanced ultrasound (CEUS) in preoperatively differential diagnosis between pancreatic solid pseudopapillary tumors (SPTs) and pancreatic neuroendocrine tumors (pNETs). PATIENTS AND METHODS:This retrospective study was approved by Institutional Review Board. Patients with surgical resection and histopathological diagnosis as SPTs and pNETs were included
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Correlation between conventional ultrasound features combined with contrast-enhanced ultrasound patterns and pathological prognostic factors in malignant non-mass breast lesions Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-12-27 Tong Wang, Wenjuan Guo, Xuemei Zhang, Ji Ma, Fang Li, Siqi Zheng, Miao Zhu, Yi Dong, Min Bai
OBJECTIVE:To investigate the correlation between ultrasound performance and prognostic factors in malignant non-mass breast lesions (NMLs). MATERIALS AND METHODS:This study included 106 malignant NMLs in 104 patients. Different US features and contrast enhancement patterns were evaluated. Prognostic factors, including histological types and grades, axillary lymph node and peritumoral lymphovascular
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Contrast-enhanced ultrasound features of hepatic sarcomatoid carcinoma different from hepatocellular carcinoma Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-12-27 Qiannan Zhao, Zhengbiao Ji, Yanling Chen, Kun Wang, Yijie Qiu, Xiaofan Tian, Yuli Zhu, Hong Qin, Hong Han, Haixia Yuan, Yi Dong, Wenping Wang
BACKGROUND: Hepatic sarcomatoid carcinoma (HSC) is a rare malignancy of the liver. The ultrasound and clinical features of HSC have not been determined. OBJECTIVE: To investigate and compare the ultrasound and clinical features of HSC and hepatocellular carcinoma (HCC), and to reveal the valuable features of HSC. METHODS: The ultrasound features and clinical data of pathologically proven HSC (n = 37)
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Changes in the pulmonary circulation due to gravitational loads in high altitude conditions Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-12-15 Venera Absatirova, Assylbek Shandaulov, Kureysh Khamchiyev, Firuz Shukurov, Fariza Khalimova
BACKGROUND: The impact of gravity on the existence of all living things has long been of interest to scientists. The force of the Earth’s gravity combined with hypoxia significantly affects blood circulation and blood accumulation in various parts of the human and animal body. To date, the relationship between body position and blood circulation in pulmonary circulation under hypobaric hypoxia has
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A nomogram based on the risk factors of cervical lymph node metastasis in papillary thyroid carcinoma coexistent with Hashimoto’s thyroiditis Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-12-12 Huanhuan Miao, Jingwen Zhong, Xuesha Xing, Jiawei Sun, Jiaqi Wu, Chengwei Wu, Yan Yuan, Xianli Zhou, Hongbo Wang
OBJECTIVE:The purpose of this study was to explore the risk factors of cervical lymph node metastasis(LNM) in papillary thyroid carcinoma(PTC) coexistent with Hashimoto’s thyroiditis(HT). METHODS:The clinical data of patients who underwent thyroid operation between November 2016 and January 2020 inour hospital were analyzed retrospectively. The association between sonographic features and the risk
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Comparison of microvascular flow imaging and contrast-enhanced ultrasound for blood flow analysis of cervical lymph node lesions Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-12-12 Tianqi Wang, Mingda Xu, Changyu Xu, Yuqing Wu, Xiaoqiu Dong
OBJECTIVE:To compare the diagnostic value of microvascular flow imaging (MVFI) with that of contrast-enhanced ultrasound (CEUS) for the analysis of blood flow in benign and malignant cervical lymph nodes. MATERIAL AND METHODS:As a prospective study, 95 cervical enlarged lymph nodes (43 benign and 52 malignant) were observed in 95 patients using conventional ultrasonography (including gray and Color
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A combination of ultrasound and contrast-enhanced ultrasound improves diagnostic accuracy for the differentiation of cervical tuberculous lymphadenitis from primary lymphoma Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-12-12 Naxiang Liu, Yijie Chen, Yaoqin Wang, Weiqin Huang, Lili Zhan, Zhongshi Du, Zhaoming Zhong, Zhougui Wu, Youhong Shen, Xiaohong Deng, Shixiong Ni, Lina Tang
OBJECTIVES:To present a method combining ultrasound (US) and contrast-enhanced ultrasound (CEUS) features for differential diagnosis of cervical tuberculous lymphadenitis (CTL) and primary lymphoma. METHODS:A total of 155 patients with CTL (n = 49) and lymphoma (n = 106) who underwent US and CEUS were retrospectively included. The features extracted from US and CEUS and the significant clinical data
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Thrombosis density ratio can predict the occurrence of pulmonary embolism and post-thrombotic syndrome in lower-extremity deep vein thrombosis patients Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-12-07 Miao-Miao Yao, Ting-Ting Lin, Xu Shi, Mei-Gui Chen, Jia-Xiang Wu, Yan-Ping Zhao, Bao-Shan Lin
Abstract OBJECTIVE: Deep vein thrombosis (DVT) formation of lower extremities can lead to serious complications including pulmonary embolism (PE) and chronic post-thrombotic syndrome (PTS). We aimed to explore the relationship between the ratio of thrombotic density and the occurrence of PE and PTS in patients with DVT of the lower extremities. METHODS: A retrospective analysis was conducted in patients
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The regulatory role and mechanism of USP14 in endothelial cell pyroptosis induced by coronary heart disease Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-12-07 Jie Gao, Zhao Gao
OBJECTIVE:The present study probes into the role and mechanism of ubiquitin specific peptidase 14 (USP14) in coronary heart disease (CHD)-triggered endothelial cell pyroptosis. METHODS:An in vitro CHD model was established by inducing human coronary artery endothelial cells (HCAECs) with oxidized low-density lipoprotein (ox-LDL). HCAECs were transfected with si-USP14, followed by evaluation of cell
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The discriminatory diagnostic value of multimodal ultrasound combined with blood cell analysis for granulomatous lobular mastitis and invasive ductal carcinoma of the breast Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-11-24 Yan-hao Zeng, Yu-ping Yang, Li-juan Liu, Jun Xie, Hai-xia Dai, Hong-lian Zhou, Xing Huang, Rong-li Huang, Er-qiu Liu, Yi-jing Deng, Hua-juan LI, Jia-jian Wu, Guo-li Zhang, Man-li Liao, Xiao-hong Xu
OBJECTIVE: To explore the discriminatory diagnostic value of multimodal ultrasound(US) combined with blood cell analysis(BCA) for Granulomatous Lobular Mastitis (GLM) and Invasive Ductal Carcinoma(IDC) of the breast. METHODS: A total of 157 breast disease patients were collected and divided into two groups based on postoperative pathological results: the GLM group(57 cases with 57 lesions) and the
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Antibiotic therapy in reconstructive surgery of deep sternal wound infections. Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-11-22 P Unbehaun,L Prantl,S Langer,N Spindler
The choice of antibiotics and length of administration in the treatment of deep sternal wound infections (DSWI) is unclear. The reason for this is the lack of studies and local differences in resistance. An increase in resistance can be observed in gram-positive cocci, which are the most frequently detected in deep sternal infections. The duration of administration is often 2- 6 weeks or longer, although
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Foreign body accompanied with thrombosis in the right internal jugular vein: A case report. Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-11-18 Nan Luo,Xiao-Yu Liang,Lu Li,Xiao Zhang,Chun-Mei Zang,Xi Liu,Xiao-Zhou Fan
A rare foreign body accompanied by thrombosis in the right internal jugular vein was accidentally observed. We collected the medical history of this special patient, analyzed the causes and characteristics of the foreign body and thrombosis formation, and subsequently observed the changes in thrombosis. Finally, we discussed the diagnostic value of ultrasound for such rare intravascular lesions.
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Wireless handheld ultrasound for internal jugular vein assessment in pediatric patients. Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-11-17 Barbara Greiner,Ulrich Kaiser,Katharina Maurer,Christian Stroszczynski,Ernst Michael Jung
BACKGROUND Rapid evolution of ultrasound technology has allowed widespread use of handheld ultrasound devices (HHUDs) for many possible applications. Along with the adult population, the use of HHUDs for Point of Care Ultrasound (POCUS) in pediatric medicine has been increasing over the last few years. However, pediatric-specific literature is still scarce on mobile vascular ultrasound. OBJECTIVE To
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The immune response to systemically administered endotoxin in the murine intestinal microcirculation under pentobarbital versus isoflurane anesthesia. Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-11-16 Daniel Neira Agonh,Cassidy Scott,Purvi Trivedi,Kayle Dickson,Hannah White,Juan Zhou,Christian Lehmann
BACKGROUND Pentobarbital and isoflurane are commonly used veterinary anesthetics. Due to the dangers of overdose by repeat-bolus regimen of pentobarbital, isoflurane has been recommended. However, literature suggests isoflurane-induced inhibition of cytokine and adhesion molecule release, impacting leukocyte adhesion. OBJECTIVE This study aims to characterize the impacts of pentobarbital versus isoflurane
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Whether the use of intravenous contrast-enhanced ultrasound can improve the accuracy of T stage diagnosis of gastric cancer? Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-11-16 Nan Wang,Xueliang Yan,Zhiqi Zhang,Luping Liu,Ju Zhu,Xiao Huang,Fang Nie
OBJECTIVE To explore whether the use of intravenous contrast-enhanced ultrasound (CEUS) can improve the diagnostic accuracy of T stage of gastric cancer on the basis of oral contrast-enhanced ultrasound (OCEUS). METHODS Eighty-one patients with gastric cancer who underwent preoperative CEUS. Criteria for T staging was AJCC Stage 8th Edition. To compare the diagnostic accuracy, sensitivity and specificity
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Predictive value for axillary lymph node metastases in early breast cancer: Based on contrast-enhanced ultrasound characteristics of the primary lesion and sentinel lymph node Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-11-07 Wenjing Pang, Yao Wang, Yangyang Zhu, Yingying Jia, Fang Nie
OBJECTIVE:To evaluate the value of contrast-enhanced ultrasound (CEUS) characteristics based on primary lesion combined with lymphatic contrast-enhanced ultrasound (LCEUS) patterns of SLN in predicting axillary lymph node metastasis (ALNM) with T1-2N0 breast cancer. METHODS:A retrospective study was conducted in 118 patients with clinically confirmed T1-2N0 breast cancer. Conventional ultrasound (CUS)
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Application of ultrasound microbubble contrast to evaluate the effect of sitaxentan on renal microvascular perfusion in beagles undergoing cardiopulmonary bypass Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-10-30 Lu Yang, Liqun Mo, Fuyu Li, Fuzu Zhu, Yiping Bai
BACKGROUND & OBJECTIVE:We aimed to evaluate the effect of sitaxentan on renal microvascular perfusion via application of ultrasound microbubble contrast. METHODS:Male beagles were randomly divided into: Sham, cardiopulmonary bypass (CPB) and sitaxentan-infused (Sit) groups (n = 6). The ascending slope rate (ASR), area under the curve (AUC), derived peak intensity, and time to peak (TTP) were obtained
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Virtual touch tissue imaging for differential diagnosis in ACR TI-RADS category 3-4 thyroid nodules: Conservative and aggressive methods Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-10-30 Kai-Mei Lian, Teng Lin
PURPOSE:Many Thyroid Imaging Reporting and Data System (TI-RADS) category 3-4 nodules are benign. Our study aimed to add virtual touch tissue imaging (VTI) to TI-RADS using two methods, namely conservative and aggressive, and to explore which method had better diagnostic performance and which method avoided more unnecessary biopsies. METHODS:From January 2016 to December 2021, we included 121 thyroid
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Protection of the endothelium and endothelial glycocalyx by hydrogen against ischaemia-reperfusion injury in a porcine model of cardiac arrest Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-10-30 David Astapenko, Radomir Hyspler, Alena Ticha, Adela Tomasova, Pavel Navratil, Marek Zrzavecky, Bhavya Byreddy, Petr Sedlacek, Vera Radochova, Roman Skulec, Robert G. Hahn, Christian Lehmann, Manu L.N.G. Malbrain, Vladimir Cerny
BACKGROUND:Hydrogen is a potent antioxidant agent that can easily be administered by inhalation. The aim of the study was to evaluate whether hydrogen protects the endothelial glycocalyx layer after successful cardiopulmonary resuscitation (CPR). METHODS:Fourteen anesthetized pigs underwent CPR after induced ventricular fibrillation. During CPR and return of spontaneous circulation, 2% hydrogen gas
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Ultrasound and clinicopathological characteristics of breast cancer for predicting axillary lymph node metastasis Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-10-30 Xiaofang Bai, Yunyue Wang, Ruxi Song, Shangan Li, Yan Song, Huan Wang, Xiaoning Tong, Wei Wei, Litao Ruan, Qiaoling Zhao
Abstract OBJECTIVES: The goal of this study was to assess the clinicopathological and ultrasound (US) features of breast cancer for predicting the risk of axillary lymph node metastasis. METHODS: Patients with breast cancer were included in this retrospective, monocentric, observational study. Their preoperative ultrasound features, clinical data, laboratory results and postoperative pathologic results
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Sublingual microcirculation in healthy pediatric population using the sidestream dark-field imaging method Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-10-30 Vlasta Krausova, David Neumann, Jaroslav Kraus, Vlasta Dostalova, Pavel Dostal
BACKGROUND:The sidestream dark-field imaging method is used to study microcirculation. Normal values of sublingual microcirculation parameters in healthy children of different age and gender categories are unknown. OBJECTIVE:The study’s main goal was to determine normal values of selected parameters of sublingual microcirculation in healthy children of different age and gender categories. METHODS:40
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Circ_0003575 knockdown alleviates ox-LDL-induced human aortic endothelial cell dysfunction in atherosclerosis by miR-637/TRAF6 axis Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-10-30 Zhanshuai Zhang, Shaoqiang Qin, Rui Wang, Zhiqin Fang, Yaling Wang, Fangjiang Li
BACKGROUND:Circular RNAs (circRNAs) are involved in the progression of atherosclerosis (AS). The present study aimed to determine the functions and mechanism of circ_0003575 in AS. METHODS:Oxidized low-density lipoprotein (ox-LDL) was used to induce human aortic endothelial cells (HAECs) to establish an AS cell model. Cell Counting Kit-8 (CCK-8) assay and 5’-ethynyl-2’-deoxyuridine (EdU) assay were
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Refractory immune thrombocytopenic purpura (ITP) after accessory splenectomy: A case report and literature review Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-10-30 Asad Riaz, Hossam Tharwat Ali, Fawad Ali, Jawad Ali
Immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by a platelet count of less than 100 x 109 /L, resulting from antibody-mediated platelet destruction. Treatment for ITP typically involves steroids, and intravenous immunoglobulins (IVIG) can be added. Splenectomy is performed in cases with refractory ITP. Rituximab can suppress immunity but has limited efficacy in ITP cases
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Colorectal liver metastases: Correlations of contrast-enhanced ultrasound features with tumor clinicopathological factors and clinical outcomes following conversion therapy. Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-10-31 Xiao-Long Zhang,Hang-Tao Wang,Yang Tang,Qing Lu,Hai-Xia Yuan,Xi Wang,Li-Heng Liu,De-Xiang Zhu,Wen-Ping Wang
OBJECTIVE To explore the prognostic impact of contrast-enhanced ultrasound (CEUS) features for initially unresectable colorectal liver metastases (CLMs) in a clinical setting of conversion therapy. METHODS Between March 2015 and November 2020, consecutive patients with CLMs who received conversion treatment were prospectively enrolled. All participants underwent liver CEUS at baseline. The primary
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Preoperative ultrasound radiomics for predicting clinically relevant postoperative pancreatic fistula after pancreatectomy. Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-10-31 Yun-Lin Huang,Xiao-Fan Tian,Yi-Jie Qiu,Wen-Hui Lou,Ernst-Michael Jung,Yi Dong,Han-Zhang Wang,Wen-Ping Wang
OBJECTIVES To evaluate the efficacy of the radiomics model based on preoperative B-mode ultrasound (BMUS) and shear wave elastography (SWE) for predicting the occurrence of clinically relevant-postoperative pancreatic fistula (CR-POPF). METHODS Patients who were scheduled to undergo pancreatectomy were prospectively enrolled and received ultrasound assessment within one week before surgery. The risk
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Multiple techniques to evaluate the relationship between carotid artery plaque and acute stroke. Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-10-31 Jianghong Chen,Bingshuang Wang,Jianshi Song,Zhengqin Qi,Yandong Deng
AIM To evaluate the important characteristics of the plaque vulnerability using multimodal ultrasound imaging methods (2D, contrast-enhanced ultrasound, and elastography), and to explore the relationship between plaque and acute stroke. METHODS A total of 244 patients with carotid plaque were enrolled, including 104 patients with acute stroke ipsilateral to the plaque as the case group and 140 patients
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Forces of interaction of red blood cells and endothelial cells at different concentrations of fibrinogen: Measurements with laser tweezers in vitro. Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-10-28 Petr B Ermolinskiy,Matvey K Maksimov,Alexey V Muravyov,Andrei E Lugovtsov,Olga N Scheglovitova,Alexander V Priezzhev
Blood microrheology depends on the constituents of blood plasma, the interaction between blood cells resulting in red blood cell (RBC) and platelets aggregation, and adhesion of RBC, platelets and leukocytes to vascular endothelium. The main plasma protein molecule -actuator of RBC aggregation is fibrinogen. In this paper the effect of interaction between the endothelium and RBC at different fibrinogen
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Zinc improved erythrocyte deformability and aggregation in patients with beta-thalassemia: An in vitro study Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-10-03 Mukaddes Sinan, Ozlem Yalcin, Zeynep Karakas, Evrim Goksel, Nesrin Zeynep Ertan
BACKGROUND:Thalassemia patients have reduced red cell deformability and decreased plasma zinc levels in their blood. OBJECTIVE:This study aimed to evaluate the effects of zinc (Zn) on the hemorheological parameters and antioxidant enzyme activities in β-thalassemia major (TM) and healthy volunteers(HV). METHODS:Hemorheological parameters were measured using LORCA (laser-assisted optical rotational
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LncRNA HCG18 loaded by polymorphonuclear neutrophil-secreted exosomes aggravates sepsis acute lung injury by regulating macrophage polarization Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-10-03 LiJun Zhu, YuLong Yu, HuiJun Wang, MingCang Wang, MinJuan Chen
Polymorphonuclear neutrophils (PMNs) exert significant roles in septic acute lung injury (ALI). Accumulating evidence suggests that PMN-derived exosomes (PMN-exo) are a novel subcellular entity that is the fundamental link between PMN-driven inflammation and tissue damage. However, the role of PMN-exo in septic ALI and the underlying mechanisms remain unclear. Tumor necrosis factor-α (TNF-α), a key
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Relationship between blood viscosity and thrombus burden in ST-segment elevation myocardial infarction Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-10-03 Mustafa Kaplangoray, Kenan Toprak, Yusuf Cekici, Arafat Yildirim, Ozge Ozcan Abacioglu
BACKGROUND:İncreased whole blood viscosity (WBV) is associated with increased infarct area, impaired microvascular circulation and mortality in patients with ST-elevation myocardial infarction (STEMI). OBJECTIVES:We aimed to analyze the association between the WBV and thrombus burden (TB) in STEMIpatients. METHODS:This cross-sectional study included 167 STEMI patients who received primary percutaneous
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Polymorphonuclear phenotypical expression of CD18, at baseline and after in vitro activation, in several clinical disorders: Revision of our case series Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-10-03 Gregorio Caimi, Rosalia Lo Presti, Caterina Carollo, Maria Montana, Melania Carlisi
BACKGROUND:In relation to the different and important roles of the beta2 integrins, we have revisited the expression of polymorphonuclear leukocyte CD18 in several clinical disorders, at baseline and after in vitro activation. SUBJECTS:we have examined subjects with type 1 diabetes mellitus, vascular atherosclerotic disease, type 2 diabetes mellitus without and with macrovascular complications, chronic
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Correlation between lipid-lowering therapy and cerebral microbleeds Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-10-03 Miao-Ping Hong, Wei-Fen Chen, Jie-Hao Wu, Tai-Shan Kang, Shun-Po He, Qing-Wei Yang
OBJECTIVE:To investigate if there is a correlation between lipid-lowering treatment with statins and the occurrence, number, and location of cerebral microbleeds (CMBs) among patients with ischemic cerebrovascular disease (ICVD), and also to compare treatment with atorvastatin and rosuvastatin in terms of the occurrence of CMBs and their differences. METHODS:In this retrospective study, we included
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Qualitative and quantitative features of deep endometriosis in contrast-enhanced ultrasound: An initial experience and literature review Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-10-03 Zijie Zheng, Shen Zhang, Cheng Zheng, Ruxue Wang, Yanping Zhang, Peixin Chen, Shanglan Zhou, Baoming Luo, Na Di
PURPOSE:This research aims to present the findings of contrast-enhanced ultrasound (CEUS) in a series of patients with proven deep endometriosis (DE) and provide an updated literature review. MATERIALS AND METHODS:Between January 2018 and October 2022, seven patients with DE lesions had their imaging and medical records retrospectively reviewed. Clinical data, recorded images of a standardized conventional
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Use of contrast-enhanced ultrasound in preoperative planning before resection of a second branchial cleft fistula Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-10-03 Maximilian Rink, Ernst-Michael Jung, Christopher Bohr, Julian Künzel
In the head and neck area, a large proportion of clinically relevant fistulas occur in childhood. The present case describes the use of contrast enhanced ultrasound with intraductal administration of the contrast medium for preoperative visualization of the fistula duct in the case of a second brachial cleft fistula. This provided the surgeon with important additional information, such as the detailed
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Intraoperative ultrasound in minimally invasive thoracic surgery for the detection of pulmonary tumors: First intrathoracic application of TE9 and laparoscopic probe Lap 13-4cs (Mindray) Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-10-03 Martin Ignaz Schauer, Ernst Michael Jung, Hans-Stefan Hofmann, Michael Ried
AIM:To apply intraoperative ultrasound (IO-US) for the first time using a laparascopic probe to detect malignancy-susceptible solitary pulmonary nodules (SPN) and assess macrovascularization using color-coded doppler sonography or power doppler. Description of technical feasibility. METHODS:Technical description on intrathoracic endoscopic ultrasound. A positive ethics vote from the local ethics committee
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Pathogens and their resistance behavior in necrotizing fasciitis. Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-09-30 Vanessa Brébant,Elisabeth Eschenbacher,Florian Hitzenbichler,Sylvia Pemmerl,Lukas Prantl,Michael Pawlik
BACKGROUND Necrotizing fasciitis (NF) is a rare but life-threatening condition in which extensive soft tissue destruction can occur very quickly if left untreated. Therefore, timely broad-spectrum antibiotic administration is of prognostic importance in addition to radical surgical debridement. AIM This study evaluates the cases of NF in our hospital during the last ten years retrospectively with respect
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Which sub-compartments of fat mass and fat-free mass are related to blood viscosity factors? Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-09-28 Jean-Frédéric Brun,Emmanuelle Varlet-Marie,Justine Myzia,Laurent Vachoud,Bénédicte Marion,Céline Roques,Eric Raynaud de Mauverger,Jacques Mercier
The size of body compartments is a determinant of several factors of blood viscosity. Red cell aggregation is proportional to fat mass while hematocrit is proportional to both fat-free mass and abdominal adiposity, but which parts of these body components are involved in this relationship is not known. Segmental bioelectrical impedance analysis (sBIA) provides a possibility to delineate the relationships
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Effects of anthracycline chemotherapy and Kuan-Sin-Yin on the spectral indices of arterial pulse waveforms in breast cancer patients Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-09-20 Chao-Tsung Chen, Tzu-Wei Huang, Yi-Sheng Chou, Chi-Feng Cheng, Hung-Bo Wu, Chung-Hua Hsu, Hsin Hsiu
The vascular structure and function are potentially useful biomarkers for tumor detection. Treatment with chemotherapeutic agents may impair vascular function and increase the risk of cardiovascular disease. This study aimed to use noninvasive pulse waveform measurements to identify differences inthe frequency-domain indices of the pulse waveform in breast-cancer patients following anthracycline chemotherapy
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JAK2 V617F mutation and circulating extracellular vesicles in essential thrombocythemia Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-09-20 Mohamed Hussam Aswad, Jarmila Kissova, Petra Ovesna, Lucie Říhová, Miroslav Penka
The clinical course of essential thrombocythemia (ET) is complicated with thrombosis which significantly impacts patients’ mortality. Studies have identified JAK2V617F mutation as an independent risk factor for thrombosis. Circulating extracellular vesicles (EVs) were evaluated in several studies regarding myeloproliferative neoplasms and thrombosis as potential biomarkers. The present study investigates
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The role of plasma in the yield stress of blood Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-09-20 U. Windberger, A. Sparer, K. Elsayad
BACKGROUND:Yielding and shear elasticity of blood are merely discussed within the context of hematocrit and erythrocyte aggregation. However, plasma might play a substantial role due its own viscoelasticity. OBJECTIVE:If only erythrocyte aggregation and hematocrit would determine yielding, blood ofdifferent species with comparable values would present comparable yield stresses. METHODS:rheometry (SAOS:
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Hemodynamics and cutaneous microcirculation during induction of general anesthesia with and without esketamine Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-09-20 Sarah Berger Veith, Rosa Nickl, Thomas Rössel, Björn Lachmann, Thea Koch, Torsten Richter
OBJECTIVE:Currently, there are limited data on the effect of macrocirculatory hemodynamic changes on human microcirculation, especially during the induction of general anesthesia (GA). METHODS:We performed a non-randomized observational trial on patients receiving GA for elective surgery. In the control group (CG), for GA induction sufentanil, propofol, and rocuronium was administered. Patients assigned
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Diagnostic performance of endorectal ultrasound combined with shear wave elastography for rectal tumors staging Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-09-20 Xue-Ying Dong, Qiang-Mei Li, Wei-Li Xue, Jia-Wei Sun, Hang Zhou, Ye Han, Xian-Li Zhou, Xiu-Juan Hou
OBJECTIVE:This study aims to analyze the performance of endorectal ultrasound (ERUS) combined with shear wave elastography (SWE) for rectal tumor staging. METHODS:Forty patients with rectal tumors who had surgery were enrolled. They underwent ERUS and SWE examinations before surgery. Pathological results were used as the gold standard for tumor staging. The stiffness values of the rectal tumor, peritumoral
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Washout appearance of hepatocellular carcinomas using standardized contrast-enhanced ultrasound (CEUS) including an extended late phase observation – Real-world data from the prospective multicentre DEGUM study Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-09-20 Barbara Meitner-Schellhaas, Daniel Jesper, Rüdiger Stephan Goertz, Sebastian Zundler, Deike Strobel
BACKGROUND:Non-invasive diagnosis of hepatocellular carcinoma (HCC) in contrast-enhanced ultrasound (CEUS) is based on the combination of arterial phase hyperenhancement (APHE) and subsequent late (>60 seconds) and mild contrast washout (WO). Whereas APHE is seen in the majority of HCC, wash-out pattern may vary in onset and intensity. In some HCC lesions, even no washout is seen at all. OBJECTIVE:Our
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Long period changes of hippocampal cerebral blood flow and its correlation with anxiety-like behavior and inflammation after incomplete cerebral ischemia reperfusion in rats Clin. Hemorheol. Microcirc. (IF 2.1) Pub Date : 2023-09-20 Lan Fu, Lin-Na Guan
OBJECTIVE:This study was designed to summarize the changes of cerebral blood flow (CBF) in the bilateral hippocampal CA1 region of the hemorrhagic shock reperfusion (HSR) model of rats and their correlation with anxiety-like behavior and inflammation. METHODS:Rats were randomly divided into the HSRgroup and the Sham group. 30 rats in each group were subdivided into 5 time points (1 w, 2 w, 4 w, 8 w