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The distribution of the depth of aortic dissection and the correlation of the dissection depth index with other parameters Cardiovasc. Pathol. (IF 3.7) Pub Date : 2024-03-28 Youping Chen, Wei Qu, Zhenlu Zhang, Mengya Li, Yang Wu
In patients with aortic dissection, the aortic wall is separated into two layers along a dissection plane. In this study, a survey was performed to investigate the distribution of the depth of dissection plane and its correlation with other clinical and pathological parameters to help understand and expand the current knowledge of aortic dissection. Pathology information system were searched for patients
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Cellular and molecular mechanisms driving cardiac tissue fibrosis: On the precipice of personalized and precision medicine Cardiovasc. Pathol. (IF 3.7) Pub Date : 2024-03-19 Ali Fatehi Hassanabad, Anna N. Zarzycki, Paul W.M. Fedak
Cardiac fibrosis is a significant contributor to heart failure, a condition that continues to affect a growing number of patients worldwide. Various cardiovascular comorbidities can exacerbate cardiac fibrosis. While fibroblasts are believed to be the primary cell type underlying fibrosis, recent and emerging data suggest that other cell types can also potentiate or expedite fibrotic processes. Over
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Subclinical Maternal Autoimmune Disease Leading to Congenital High Degree Atrioventricular Block: Case Report and Review of the Literature Cardiovasc. Pathol. (IF 3.7) Pub Date : 2024-03-18 Shelby E Walcott, Dr. Christian H Tan, Dr. Jason Wicker, Dr. Silvio Litovsky
Maternal autoimmune disease is the most common cause of congenital heart block (CHB), a rare illness characterized by fibrosis and calcification of the fetal atrioventricular (AV) node due to maternal autoantibodies anti-SSA/Ro and anti-SSB/La. We report the full autopsy and clinical information on a female neonate with high degree AV block and calcification in the AV node, atrial approaches to the
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Frequent protein kinase A regulatory subunit A1 mutations but no GNAS mutations as potential driver in sporadic cardiac myxomas Cardiovasc. Pathol. (IF 3.7) Pub Date : 2024-03-15 Annette Zimpfer, Liza M. Abel, Anthony Alozie, Christian D. Etz, Björn Schneider
Cardiac myxomas (CMs) are the second most common benign primary cardiac tumors, mainly originating within the left atrium. Approximately 5% of CM cases are associated with Carney Complex (CNC), an autosomal dominant multiple neoplasia syndrome often caused by germline mutations in the protein kinase A regulatory subunit 1A (). Data concerning alterations in sporadic myxomas are variable and sparse
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Sudden death with cardiac involvement in a neonate with carnitine-acylcarnitine translocase deficiency Cardiovasc. Pathol. (IF 3.7) Pub Date : 2024-03-14 Jiayu Jing, Cui Zhang, Sihao Du, Xiaohui Tan, Xia Yue, Dongfang Qiao
A female neonate born with normal Apgar scores at 38+2 weeks of gestational age unexpectedly passed away within less than 30 hours after birth. The situation mirrored her brother's earlier demise within 24 hours post-delivery, suggesting a possible genetic disorder. Gross examination revealed widespread cyanosis and distinct yellowish changes on the cardiac ventricles. Histopathological examination
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Sudden Unexpected Intrapartum Death and Left Ventricular Noncompaction involving the Right Ventricle Cardiovasc. Pathol. (IF 3.7) Pub Date : 2024-03-12 Giulia Ottaviani, Tobia Tomasello, Francesca Boggio, Letterio Runza, Alessandro Del Gobbo, L. Maximilian Buja
Left ventricular noncompaction (LVNC), involving mainly the right ventricle, is a rare form of congenital heart disorder characterized by a developmental arrest in myocardial compaction, resulting in a spongy appearance of the myocardium, mainly of the right ventricle, rarely detected in fetuses. We report the case of a female fetus with a gestational age of 41 weeks who came to our attention for intrapartum
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Aortic valve fibroelastoma presenting with myocardial infarction with non-obstructive coronary arteries (MINOCA): a case report and review of the literature Cardiovasc. Pathol. (IF 3.7) Pub Date : 2024-03-10 Martino Pepe, Rocco Tritto, Maria Ludovica Naccarati, Simona Quarta, Andrea Marzullo, Marco Matteo Ciccone
Cardiac papillary fibroelastomas (CPFs) are rare benign cardiac tumors more often involving the left-sided valves and related with threatening embolic complications. We report the case of a 35-year-old woman presenting with relapsing-remitting chest pain and elevated cardiac troponins. After a negative coronary angiography, an integrated imaging assessment based on echocardiography and cardiac magnetic
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The potential involvement of glycocalyx disruption in abdominal aortic aneurysm pathogenesis Cardiovasc. Pathol. (IF 3.7) Pub Date : 2024-03-09 Bibi Rabia, Shivshankar Thanigaimani, Jonathan Golledge
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3D models of the cardiac conduction system in healthy neonatal human hearts Cardiovasc. Pathol. (IF 3.7) Pub Date : 2024-03-06 Brian Cottle, Karl Schriewer, Sarthak Tiwari, Dylan Miller, Aditya Kaza, Robert Hitchcock, Frank B. Sachse
Iatrogenic damage to the cardiac conduction system (CCS) remains a significant risk during congenital heart surgery. Current surgical best practice involves using superficial anatomical landmarks to locate and avoid damaging the CCS. Prior work indicates inherent variability in the anatomy of the CCS and supporting tissues. This study introduces high-resolution, 3D models of the CCS in normal pediatric
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Multisystem Erdheim-Chester disease presenting with pericardial effusion confirmed by the effusion cytology specimen Cardiovasc. Pathol. (IF 3.7) Pub Date : 2024-02-28 Shishuo Dai, Xueying Su, Wei-ping Liu, Yu Wu
Erdheim-Chester disease (ECD) is a rare histiocytosis characterized by the foamy CD68+CD1a- histiocytes infiltrating multiple organs and tissues. ECD might be asymptomatic or present with variable manifestations. The diagnosis of ECD requires characteristic radiological findings and pathological features. Herein, we described a 52-year-old female patient who was admitted to our hospital for recurrent
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Transthyretin-derived amyloid (ATTR) and sarcoidosis: Does ATTR deposition cause a granulomatous inflammatory response in older adults with sarcoidosis? Cardiovasc. Pathol. (IF 3.7) Pub Date : 2024-02-25 Shojiro Ichimata, Yukiko Hata, Kazuhiro Nomoto, Naoki Nishida
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Rare primary cardiac myxofibrosarcoma in adolescence: diagnostic challenges and surgical insights. Cardiovasc. Pathol. (IF 3.7) Pub Date : 2024-02-17 Jesús Machuca-Aguado, Rosa Rendón García, Alessia Miraglia, Juan Carlos Téllez-Cantero, Álvaro Gutiérrez-Domingo
This article presents a unique case of primary myxofibrosarcoma, an exceptionally rare cardiac neoplasm, in a 16-year-old girl. With fewer than 40 documented cases, this tumor's occurrence in adolescence is particularly uncommon. The patient presented with right-sided paraesthesia and subsequent right hemiparesis and dysarthria, along with bilateral pleural effusion. Imaging tests revealed a cerebral
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The Minimal Criteria for Active Arteritis in a Temporal Artery Biopsy Cardiovasc. Pathol. (IF 3.7) Pub Date : 2024-02-15 James R. Stone, Vidhya Nair, Gregory A. Fishbein
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Re: Nair et al. Consensus Statement on the Processing, Interpretation and Reporting of Temporal Artery Biopsy for Arteritis [1] Cardiovasc. Pathol. (IF 3.7) Pub Date : 2024-02-14 Dr Dilek Taze
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Are telocytes related to maintenance of vascular homeostasis in normal and pathological aorta? Cardiovasc. Pathol. (IF 3.7) Pub Date : 2024-02-01 Luciano Figueiredo Borges, Rafael Souza Pereira Falcão, Sebastião Roberto Taboga, Paulo Sampaio Gutierrez, Jean-Baptiste Michel
The telocyte (TC) is a new interstitial cell type described in a wide variety of organs and loose connective tissues around small vessels, but its presence in large arteries remains unexplored. TCs have small cell bodies and remarkably thin, long, moniliform processes called telopods (Tps). Using transmission electron microscopy and immunofluorescence, we identified TCs in normal human thoracic aortas
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BICUSPID AORTIC VALVE: THE MOST FREQUENT AND NOT SO BENIGN CONGENITAL HEART DISEASE Cardiovasc. Pathol. (IF 3.7) Pub Date : 2024-01-20 Gaetano Thiene, Stefania Rizzo, Cristina Basso
Bicuspid aortic valve (BAV) is the most frequent congenital heart disease, with an incidence of approximately 1%. It can be silent and associated with normal valve function. However, a series of complications, even catastrophic, may occur with time: valve incompetence, valve stenosis by dystrophic calcification, infective endocarditis, progressive dilatation of the ascending aorta, aortic dissection
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Neovascularization of native cardiac valves, and correlation with histopathologic, clinical, and radiologic features Cardiovasc. Pathol. (IF 3.7) Pub Date : 2024-01-19 Simona Pichler Sekulic, Miroslav Sekulic
Native cardiac valves in the setting of chronic injury undergo remodeling that includes fibrous thickening and dystrophic calcification, as well as neovascularization, that result in abnormal valve function. In order to characterize the presence of neovascularization in valves, a retrospective review of 1246 sequentially reviewed native cardiac valves of all types was performed, with correlation with
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Commotio cordis: Another cardiac arrest “sine materia”. The 1707 early report and interpretation by Giovanni Maria Lancisi Cardiovasc. Pathol. (IF 3.7) Pub Date : 2024-01-21 Daniela Marrone, Cristina Basso, Gaetano Thiene
Sudden death by commotio cordis is rare. It is the consequence of a blunt trauma of the chest overlying the heart.
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Variations in subtle cystic tumors of the atrioventricular node: five autopsy cases Cardiovasc. Pathol. (IF 3.7) Pub Date : 2024-01-20 Hisanori Muramatsu, Kumiko Asakura, Tadashi Hosoya, Akira Kurosu
Cystic tumor of the atrioventricular node (CTAVN) is the most common primary cardiac tumor cause of sudden death but is rarely found during forensic autopsy. We present five autopsy cases of sudden death from undiagnosed CTAVN. The tumors varied in their histological appearance, which may be related to their variation in clinical presentation. Some of the cases had been diagnosed with epilepsy before
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Society for Cardiovascular Pathology Journal Club: Fulminant Myocarditis Proven by Early Biopsy and Outcomes Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-12-15 Carla Giordano
Abstract not available
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A cardiac intimal sarcoma mimicking infective endocarditis Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-12-13 Emma Bergonzoni, Monica De Gaspari, Augusto D'Onofrio, Giorgia Cibin, Stefania Rizzo, Cristina Basso, Gino Gerosa
Primary malignant cardiac tumors are rare and usually misdiagnosed because they can mimic more common intracardiac lesions, therefore, in clinical practice it is important to always consider even uncommon diseases in order to avoid delayed diagnosis and to plan the most appropriate therapeutic strategy in a timely fashion. We report a case of a 73-year-old man with clinical signs and imaging findings
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Detailed study of collagen, vasculature, and innervation in the human cardiac conduction system Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-12-16 Denis Depes, Ari Mennander, Timo Paavonen, Mary N. Sheppard, Ivana Kholová
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A fetal rat model of ventricular noncompaction caused by intrauterine hyperglycemia Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-12-10 Fanglu Wang, Songbo Han, Ligang Fang, Xue Lin
Background This study aims to develop a fetal rat model of ventricular noncompaction (NVM) using streptozotocin (STZ)-induced gestational hyperglycemia and compare it with a retinoic acid (RA) model. Methods Female SD rats were categorized into STZ, RA, and normal control (NC) groups. The STZ group was given a high-fat diet pre-pregnancy and 35 mg/kg of 2% STZ postpregnancy. The RA group received a
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Carney complex: A clinicopathologic study on a single family from several Canadian provinces Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-12-10 Alexandra Lao, Julio Silva, Brian Chiu, Consolato M. Sergi
Carney syndrome is an autosomal dominant complex involving endocrinopathy, mucocutaneous hyperpigmentation, and different tumors, including cardiac myxomas. We report on a single family with several members affected with Carney syndrome. Family and individual medical histories were investigated in several Canadian provinces. The histology slides were also reviewed. Four family members (two young women
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COVER 4: Table of Contents/Barcode PMS 200 Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-12-08
Abstract not available
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Sudden unexpected death of a young adult due to subarachnoid hemorrhage associated with polyarteritis nodosa: Clinicopathological appearance and literature review Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-12-09 Shojiro Ichimata, Yukiko Hata, Koji Yoshida, Ryo Tanaka, Naoki Nishida
A 28-year-old male was found dead in his bedroom. There were no anomalies in his birth and medical history, and there was no family history of sudden unexpected death (SUD). Autopsy showed subarachnoid hemorrhage (SAH) with basilar top inflammatory pseudoaneurysm rupture accompanied by fibrinoid necrosis in the aneurysm wall. Active and healed arteritides in small- to medium-sized arteries were identified
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Subendocardial “ischemic-like” state in patients with severe aortic stenosis: Insights from myocardial histopathology and ultrastructure Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-11-28 João Abecasis, Sergio Maltês, Rita Reis Santos, Pedro Lopes, Rita Theias Manso, Victor Gil, Nuno Cardim, Sancia Ramos, Ana Félix
Background Myocardial adaptation to severe aortic stenosis (AS) is a complex process that involves myocardial fibrosis (MF) beyond cardiomyocyte hypertrophy. Perfusion impairment is believed to be involved in myocardial remodeling in chronic pressure overload. Aim To describe morphological and ultrastructural myocardial changes at endomyocardial tissue sampling, possibly reflecting subendocardial ischemia
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Characteristics of Lambl excrescences of aortic and pulmonary valves in healthy hearts Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-11-19 Abhinav Goyal, Andrew J. Layman, Melanie C. Bois, Joseph J. Maleszewski
Lambl excrescences (LEs) were initially described in the mid-1800s during autopsies of human hearts, and their significance and biology have been debated ever since. LEs are typically found on aortic and pulmonary valve (semilunar) cusps. There is debate concerning whether LEs are a significant cause of thromboembolic events, or whether they are harmless growths. However, there have not been many reports
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Fetal cystic and solid tumor of the atrioventricular node: Autopsy diagnosis at 12 weeks of gestational age Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-11-04 Rosete Nogueira, Beatriz Marinho-Cardoso, Marcos Gomes, Graça Amorim
Primary cardiac tumors are uncommon clinical entities with an incidence of 0.0017% to 0.03% of all autopsies. Cystic tumor of the atrioventricular node (CTAVN) comprises of 2.7% of cardiac tumors causing sudden death associated with complete heart block. CTAVN is a congenital benign cystic and solid mass located in the triangle of Koch in atrioventricular nodal region of the heart. It has been described
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Digital pathology in cardiac transplant diagnostics: from biopsies to algorithms Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-11-03 Martin Kveton, Lukas Hudec, Ivan Vykopal, Matej Halinkovic, Miroslav Laco, Andrea Felsoova, Wanda Benesova, Ondrej Fabian
In the field of heart transplantation, the ability to accurately and promptly diagnose cardiac allograft rejection is crucial. This comprehensive review explores the transformative role of digital pathology and computational pathology, especially through machine learning, in this critical domain. These methodologies harness large datasets to extract subtle patterns and valuable information that extend
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COVER 4: Table of Contents/Barcode PMS 200 Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-10-18
Abstract not available
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Society for Cardiovascular Pathology Journal Club: Obesity-related heart disease Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-10-14 Joseph Westaby
Abstract not available
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GDF5 deficiency prevents cardiac rupture following acute myocardial infarction in mice Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-10-13 Eric A. Shikatani, Tao Wang, Luke S. Dingwell, Colin White-Dzuro, Abdul Momen, Mansoor Husain
Background We previously showed that growth differentiation factor 5 (GDF5) limits infarct expansion post-myocardial infarction (MI). We now examine the acute post-MI role of GDF5 in cardiac rupture. Methods and Results Following permanent ligation of the left anterior descending artery, GDF5 deficiency (i.e., GDF5 knockout mice) reduced the incidence of cardiac rupture (4/24 vs. 17/24; P < .05), and
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Characterization of heart disease in mucopolysaccharidosis type II mice Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-09-18 Angela Maria Vicente Tavares, Esteban Alberto Gonzalez, Isabelle Souza Viana, Fernanda Visioli, Luisa Natalia Pimentel Vera, Guilherme Baldo
Mucopolysaccharidosis type II (MPSII) is a progressive lysosomal storage disease caused by mutations in the IDS gene, that leads to iduronate 2-sulfatase (IDS) enzyme deficiency. The enzyme catalyzes the first step of degradation of two glycosaminoglycans (GAGs), heparan sulfate (HS) and dermatan sulfate (DS). The consequences of MPSII are progressively harmful and can lead to death by cardiac failure
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Primary myocardial fibrosis — a distinct entity characterized by heterogeneous histology Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-09-06 Lasse Pakanen, Henrik Appel, Anne Ahtikoski, Pernille Heimdal Holm, Mervi Kreus, Kristine Boisen Olsen, Jytte Banner, Bo Gregers Winkel, Heikki Huikuri, Riitta Kaarteenaho, Juhani Junttila
Primary myocardial fibrosis (PMF), defined as myocardial fibrosis in the absence of identifiable causes, may represent a common alternative phenotype in various cardiomyopathies and contribute to sudden cardiac death (SCD). No previous definitions of histopathological characteristics exist for PMF. We aimed to evaluate whether common features of fibrosis could be identified. PMF cases (n = 28) were
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Consensus statement on the processing, interpretation and reporting of temporal artery biopsy for arteritis Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-09-06 Vidhya Nair, Gregory A. Fishbein, Robert Padera, Michael A. Seidman, Mathieu Castonguay, Charles Leduc, Carmela D. Tan, E Rene Rodriguez, Joseph J. Maleszewski, Dylan Miller, Maria Romero, Jon Lomasney, Giulia d'Amati, Monica De Gaspari, Stefania Rizzo, Annalisa Angelini, Cristina Basso, Silvio Litovsky, Louis Maximilian Buja, James R. Stone, John P. Veinot
Giant cell arteritis (GCA) is the most common systemic vasculitis in adults in Europe and North America, typically involving the extra-cranial branches of the carotid arteries and the thoracic aorta. Despite advances in noninvasive imaging, temporal artery biopsy (TAB) remains the gold standard for establishing a GCA diagnosis. The processing of TAB depends largely on individual institutional protocol
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In memoriam William Clifford Roberts, MD (September 11, 1932 June 15, 2023) Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-08-23 Louis Maximilian Buja
Abstract not available
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COVER 4: Table of Contents/Barcode PMS 200 Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-08-16
Abstract not available
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The microenvironment of the atheroma expresses phenotypes of plaque instability Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-08-16 Angela Yan, Avrum I. Gotlieb
Data from histopathology studies of human atherosclerotic tissue specimens and from vascular imaging studies support the concept that the local arterial microenvironment of a stable atheroma promotes destabilizing conditions that result in the transition to an unstable atheroma. Destabilization is characterized by several different plaque phenotypes that cause major clinical events such as acute coronary
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Seeing beyond apoptosis: ultrastructural aspects of necrosis in human atherosclerosis Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-07-14 Ida Perrotta
In recent years, there has been an explosive growth of research to decipher the pathobiologic relevance of cell death in the development and progression of various cardiovascular disorders such as arterial remodeling and atherosclerosis. High rates of cell death have been reported in animal models, particularly following balloon catheter injury. Also, in humans there is considerable evidence indicating
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The heart is the sun of the microcosm: William Harvey revolution Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-07-08 Daniela MARRONE, Cristina BASSO, Gaetano THIENE
Abstract not available
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Necrotizing plasma cell-rich aortitis and sudden cardiac death: Late sequelae of COVID-19? Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-07-05 Paul J. Boor, Mukund Srinivasan, Heather L. Stevenson, Bin Gong, Emmanuel Nyong, Jianli Dong, Vsevolod Popov, Michael Sherman, Nathen Bopp, Michelle M. Felicella, Bihong Zhao, Maximilian Buja, Jacklyn Nickels, Judith F. Aronson
The ongoing epidemic caused by the coronavirus SARS-CoV-2 is characterized by a variety of pathologic processes within the syndrome of COVID-19. Usually beginning as an upper respiratory infection with potential progression to a pneumonitis, many cases of COVID-19 that show minimal signs or symptoms initially may develop adverse systemic sequelae later, such as widespread thrombo-embolic phenomena
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Characteristics of aortic and pulmonary valve cusp fenestrations in healthy hearts Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-06-30 Abhinav Goyal, Andrew J. Layman, Melanie C. Bois, Joseph J. Maleszewski
Fenestrations in semilunar valves of human hearts have been incidentally described during autopsies since the 1800s, and were thought to be a degenerative process of the valve cusps. Due to the nature of autopsy, prior literature has primarily examined these fenestrations in pathologic hearts, and has implicated them in leading to valve insufficiency, regurgitation, and cusp rupture. More recent studies
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Histological evidence of a connection between true and false lumen in spontaneous coronary artery dissection Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-06-29 Charlotte A. Houck, Gilles F.H. Diercks, David Adlam, Mary N. Sheppard, Aryan Vink
The pathophysiological mechanism underlying spontaneous coronary artery dissection remains unclear. Although an endothelial-intimal disruption is assumed to be involved as either a primary or secondary event, the presence of a tear in the coronary intima has not been histologically presented, to our knowledge. We present three autopsy cases of spontaneous coronary artery dissection in which histopathological
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Current cardiovascular manuscripts: Society for Cardiovascular Pathology journal club Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-06-18 Marc K. Halushka
Abstract not available
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Smooth muscle differentiation of coronary intima in autopsy tissues after sirolimus-eluting stent implantation Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-06-13 Atsushi Kurata, Yuichiro Harada, Koji Fujita, Shin-ichiro Ohno, Masakatsu Takanashi, Saeko Yoshizawa, Yoji Nagashima, Toshitaka Nagao, Junichi Yamaguchi, Masahiko Kuroda
Background In coronary atherosclerotic disease, the proliferation of intimal smooth muscle cells (SMCs) is regarded as beneficial with respect to stable and unstable plaques, but is thought detrimental in discussions on coronary stent restenosis. To resolve this discrepancy, we focused on the quality, not quantity, of intimal SMCs in coronary atherosclerotic disease. Methods Autopsied coronary artery
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Atheroprotective effect of myocardial bridge sustains in aging: Autopsy study on subjects with dual left anterior descending coronary artery type 3 Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-06-13 Aleksa Leković, Slobodan Nikolić
Background The atheroprotective role of the myocardial bridge (MB) on a tunneled segment is already demonstrated in subjects with dual left anterior descending coronary artery (dual LAD) type 3 anomaly, but the dynamics of changes and whether this protective effect sustains during aging is unknown. Methods The retrospective autopsy study included cases of dual LAD type 3 anomaly identified over 18
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COVER 4: Table of Contents/Barcode PMS 200 Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-05-30
Abstract not available
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Is carotid web an arterial wall dysplasia? A histological series Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-05-30 Louise Z Wang, David Calvet, Pierre Julia, Valérie Domigo, Nassim Mohamedi, Jean-Marc Alsac, Salma El Batti, Emmanuel Messas, Tristan Mirault, Patrick Bruneval, Guillaume Goudot
Introduction Described for 60 years under various names, the carotid web is a suspected cause of cryptogenic stroke, especially in young patients. The web creates an intraluminal protrusion that may contribute to turbulent flow and thrombus embolization into cerebral arteries. Although the carotid web has frequently been related to arterial fibrodysplasia, its natural history and pathological description
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Postmortem diagnosis of Takotsubo syndrome on autoptic findings: is it reliable? A systematic review Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-05-09 Simone Grassi, Oscar Campuzano, Francesca Cazzato, Mònica Coll, Alessandra Puggioni, Massimo Zedda, Vincenzo Arena, Anna Iglesias, Georgia Sarquella-Brugada, Vilma Pinchi, Ramon Brugada, Antonio Oliva
Takotsubo syndrome (TTS) is a cardiac syndrome characterized by transient left ventricular systolic dysfunction in the absence of significant obstructive coronary artery disease. At the autopsy, its diagnosis is often challenging, since it is generally thought that it relates to no characteristic macroscopic or microscopic findings. In order to verify this last statement, we performed a systematic
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Quantitative assessment of myocardial fibrosis by digital image analysis: An adjunctive tool for pathologist “ground truth” Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-04-29 João Abecasis, Nuno Cortez-Dias, Daniel Gomes Pinto, Pedro Lopes, Márcio Madeira, Sancia Ramos, Victor Gil, Nuno Cardim, Ana Félix
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Primary cardiac lipoblastoma of the right atrium Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-04-29 Miroslav Koblizek, William Golas, Lenka Krskova, Jan Kovanda, Petr Bukovsky, Josef Zamecnik
Lipoblastoma is a rare neoplasm of the embryonal white fat. It occurs most commonly in children under the age of 3 years and usually inflicts the superficial soft tissues of trunk and extremities. We present the case of a 3-year-old male patient with a successfully resected primary cardiac right-atrial lipoblastoma with COL1A2::PLAG1 gene fusion.
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Pathology Musings - Society for Cardiovascular Pathology Distinguished Achievement awardee lecture 2023 Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-04-27 John P. Veinot
Abstract not available
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Molecular genetic characterization of sudden deaths due to thoracic aortic dissection or rupture Cardiovasc. Pathol. (IF 3.7) Pub Date : 2023-04-27 Sarah Saxton, Gregory Dickinson, Dawei Wang, Bo Zhou, Sung Yon Um, Ying Lin, Lisa Rojas, Barbara A. Sampson, Jason K. Graham, Yingying Tang
Background Sudden deaths due to thoracic aortic dissection or rupture (TADR) are often investigated by forensic pathologists in the United States. Up to a quarter of reported TADR result from a highly penetrant autosomal dominant single gene variant. Testing genes associated with familial TADR provides an underlying etiology for the cause of death and informs effective sudden death prevention for at-risk