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Comparative study of venous thromboembolic prophylaxis strategies in hemorrhagic stroke: a systematic review and network meta-analysis Int. J. Stroke (IF 6.7) Pub Date : 2024-04-09 Giorgio Maraziti, Maria Giulia Mosconi, Maurizio Paciaroni
Background:Venous thromboembolic events, including deep vein thrombosis (DVT) and pulmonary embolism (PE), are frequent complications in patients with intracerebral hemorrhage (ICH). Various prophylactic strategies have been employed to mitigate this risk, such as heparin, intermittent pneumatic compression (IPC), and graduated compression stockings (GCS). The optimal thromboembolic prophylaxis approach
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Early REperfusion Therapy with Intravenous Alteplase for Recovery of VISION in Acute Central Retinal Artery Occlusion (REVISION): Study Protocol of a Phase III Trial Int. J. Stroke (IF 6.7) Pub Date : 2024-04-09 Sven Poli, Carsten Grohmann, Daniel A. Wenzel, Khouloud Poli, Johannes Tuennerhoff, Max Nedelmann, Jens Fiehler, Hansjürgen Agostini, Bruce Campbell, Dominik M. Fischer, Marek Sykora, Brian Mac Grory, Nicolas Feltgen, David J Seiffge, Daniel Strbian, Maximilian Schultheiß, Martin S. Spitzer
Rationale:Meta-analyses of case series of non-arteritic central retinal artery occlusion (CRAO) indicate beneficial effects of intravenous thrombolysis when initiated early after symptom onset. Randomized data is lacking to address this question.Aims:REVISION investigates intravenous alteplase within 4.5 hours of monocular vision loss due to acute CRAO.Methods:Randomized (1:1), double-blind, placebo-controlled
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Clinical Change During Inter-Hospital Transfer For Thrombectomy: Incidence, Associated Factors and Relationship With Outcome Int. J. Stroke (IF 6.7) Pub Date : 2024-04-05 Pierre Seners, Adrien Ter Schiphorst, Anke Wouters, Nicole Yuen, Michael Mlynash, Caroline Arquizan, Jeremy J. Heit, Stephanie Kemp, Soren Christensen, Denis Sablot, Anne Wacongne, Thibault Lalu, Vincent Costalat, Gregory W Albers, Maarten G Lansberg
Background:Patients with acute ischemic stroke with a large vessel occlusion (LVO) admitted to non endovascular-capable centers often require inter-hospital transfer for thrombectomy. We aimed to describe the incidence of substantial clinical change during transfer, the factors associated with clinical change, and its relationship with 3-month outcome.Methods:We analyzed data from two cohorts of acute
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Global, regional, and national burden of stroke from 1990 to 2019: a temporal trend analysis based on the Global Burden of Disease Study 2019 Int. J. Stroke (IF 6.7) Pub Date : 2024-04-03 Liwei Zhang, Hao Lu, Chunhua Yang
Background:Stroke is the second leading cause of death and the leading cause of disability worldwide. However, how the the prevalence of stroke varies across the world is uncertain.Aims:The aim of this study was to and analyze temporal trends of prevalence for Stroke, including Ischemic stroke (IS), Intracerebral hemorrhage (ICH), and Subarachnoid hemorrhage (SAH) at the global, regional, and national
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Baseline clinical and neuroradiological predictors of outcome in patients with large ischemic core undergoing mechanical thrombectomy: a retrospective multicenter study Int. J. Stroke (IF 6.7) Pub Date : 2024-03-28 Andrea Alexandre, Mauro Monforte, Valerio Brunetti, Luca Scarcia, Luigi Cirillo, Andrea Zini, Irene Scala, Vincenzo Nardelli, Francesco Arbia, Giuseppe Arbia, Giovanni Frisullo, Erwah Kalsoum, Arianna Camilli, Davide De Leoni, Colò Francesca, Serena Abruzzese, Mariangela Piano, Claudia Rollo, Antonio Macera, Maria Ruggiero, Elvis Lafe, Joseph Domenico Gabrieli, Giacomo Cester, Nicola Limbucci, Francesco
BackgroundRecent randomized trials have shown the benefit of mechanical thrombectomy (MT) also in patients with an established large ischemic core.AimThe purpose of this study was to define baseline predictors of clinical outcome in patients with large vessel occlusion (LVO) in the anterior circulation and an Alberta Stroke Program Early CT score (ASPECTS) ≤ 5, undergoing MT.Material and methodsThe
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An automated flowchart for the Modified Rankin Scale assessment: a multicenter inter-rater agreement analysis Int. J. Stroke (IF 6.7) Pub Date : 2024-03-28 Joao Brainer Clares de Andrade, Terence Joseph Quinn, Leonardo Augusto Carbonera, Vinicius Montanaro, Alexandre Robles, Rafael Padua, Saulo Ribeiro, Gisele Sampaio Silva
Background and objectiveThe Modified Rankin Scale (mRS) is a widely adopted scale for assessing stroke recovery. Despite limitations, the mRS has been adopted as primary outcome in most recent clinical acute stroke trials. Designed to be used by multidisciplinary clinical staff, the congruency of this scale is not consistent, which may lead to mistakes in clinical or research application. We aimed
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Predicting post-stroke cognitive impairment using electronic health record data Int. J. Stroke (IF 6.7) Pub Date : 2024-03-28 Jeffrey M Ashburner, Yuchiao Chang, Bianca Porneala, Sanjula D Singh, Nirupama Yechoor, Jonathan M Rosand, Daniel E Singer, Christopher D Anderson, Steven J Atlas
Background:Secondary prevention interventions to reduce post-stroke cognitive impairment (PSCI) can be aided by the early identification of high-risk individuals who would benefit from risk factor modification.Aims:To develop and evaluate a predictive model to identify patients at increased risk of PSCI over 5 years using data easily accessible from electronic health records.Methods:Cohort study that
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Are Central and Systemic Inflammation associated with Fatigue in Cerebral Small Vessel Disease? Int. J. Stroke (IF 6.7) Pub Date : 2024-03-27 Amy A Jolly, Robin B Brown, Daniel J Tozer, Young T Hong, Tim D Fryer, Franklin Aigbirhio, John O'brien, Hugh S Markus
BackgroundFatigue is a common symptom in cerebral small vessel disease (SVD), but its pathogenesis is poorly understood. It has been suggested that inflammation may play a role. We determined whether central (neuro) inflammation and peripheral inflammation were associated with fatigue in SVD.Methods36 patients with moderate to severe SVD underwent neuropsychometric testing, combined PET-MRI and blood
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A randomised controlled trial of medication adherence and management of risk factors for secondary prevention of stroke (MaMoRS) using a smartphone-based application. Int. J. Stroke (IF 6.7) Pub Date : 2024-03-27 Veena Babu, P.N. Sylaja, Biju Soman, Ravi Prasad Varma, Manju M S, G L Geethu, Suresh Kumar
Background:There is little data on the use of smartphone-based applications for medication adherence and risk-factor control for the secondary prevention of stroke in low-and-middle-income countries (LMIC).Aims:To determine whether a smartphone-based app improved medication adherence, risk-factor control, and provided health education to stroke survivors for lifestyle and behavioural modifications
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Treating inflammation to reduce stroke risk, non-motor symptoms after stroke, cerebral microinfarcts in cancer, and prognosis in cervical dissection Int. J. Stroke (IF 6.7) Pub Date : 2024-03-25 Hugh S Markus
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Post-stroke emotionalism; diagnosis, pathophysiology, and treatment Int. J. Stroke (IF 6.7) Pub Date : 2024-03-20 Niall Broomfield, Joshua Blake, Fergus Gracey, Tom Steverson
Post-stroke emotionalism affects 1 in 5 stroke sufferers 6 months after their stroke, but despite its frequency remains a poorly understood stroke symptom. The literature is limited, especially compared to other frequently observed neurological conditions such as aphasia and visual neglect. This narrative review presents a summary of this literature, to inform clinical practice and future research
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Large vessel occlusive stroke with milder baseline severity show better collaterals and reduced harm from thrombectomy transfer delays Int. J. Stroke (IF 6.7) Pub Date : 2024-03-20 Hannah R. Rowling, Dominic Italiano, Leonid Churilov, Logesh Palanikumar, Jackson Harvey, Timothy Kleinig, Mark Parsons, Peter Mitchell, Stephen M Davis, Nyika Kruyt, Bruce Campbell, Henry Zhao
Background:Patients with large vessel occlusion (LVO) stroke presenting with milder baseline clinical severity are common and require endovascular thrombectomy. However, such patients are difficult to recognize using pre-hospital severity-based triage tools and therefore are likely to require a secondary inter-hospital transfer if transported to a non-thrombectomy center. Given the potential for milder
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Reducing the global burden of cerebral venous thrombosis: an international research agenda Int. J. Stroke (IF 6.7) Pub Date : 2024-03-18 Jonathan M. Coutinho, Anita van de Munckhof, Diana Aguiar de Sousa, Sven Poli, Sanjith Aaron, Antonio Arauz-Góngora, Adriana Conforto, Katarzyna Krzywicka, Sini Hiltunen, Erik Lindgren, Mayte Sanchez van Kammen, Liqi Shu, Tamam Bakchoul, Rosalie Belder, Rene van den Berg, Elisheva Boumans, Suzanne Cannegieter, Vanessa Cano-Nigenda, Thalia Shoshana Field, Isabel Fragata, Mirjam R Heldner, María Hernández-Pérez
BackgroundDue to the rarity of cerebral venous thrombosis (CVT), performing high-quality scientific research in this field is challenging. Providing answers to unresolved research questions will improve prevention, diagnosis, and treatment, and ultimately translate to a better outcome of patients with CVT. We present an international research agenda, in which the most important research questions in
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Trigger Factors In Patients With A Patent Foramen Ovale Associated Stroke: A Case-Crossover Study Int. J. Stroke (IF 6.7) Pub Date : 2024-03-18 Maikel Immens, Merel Sanne Ekker, Esmee Verburgt, Jamie Verhoeven, Mijntje Schellekens, Nina Hilkens, Esther Boot, Mayte van Alebeek, Paul J.A.M. Brouwers, Renate Arntz, Gert van Dijk, Rob Gons, Inge van Uden, Tom den Heijer, Paul L.M. de Kort, K de Laat, Anouk GW van Norden, Sarah E Vermeer, Marian van Zagten, Robert J. van Oostenbrugge, Marieke Wermer, Paul J Nederkoorn, Henk Kerkhoff, F Rooyer,
Background:Patent foramen ovale (PFO) is a congenital anatomical variant which is associated with strokes in young adults. Contrary to vascular risk factors and atherosclerosis, a PFO is present from birth. However, it is completely unknown how an anatomical structure that is already present at birth in a large proportion of the population, can convert into a PFO that causes stroke in a few. Recent
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Individual patient data meta-analysis of the effects of fluoxetine on functional outcomes after acute stroke Int. J. Stroke (IF 6.7) Pub Date : 2024-03-18 Gillian Elizabeth Mead, Catriona Graham, Erik Lundström, Graeme J Hankey, Maree L Hackett, Laurent Billot, Per Näsman, John Forbes, Martin Dennis
BackgroundThree large randomised controlled trials of fluoxetine for stroke recovery have been performed. We perfomed an individual patient data meta-analysis (IPDM) on the combined data.MethodsFixed effects meta-analyses was performed on the combined data set, for the primary outcome (modified Rankin scale (mRS) at 6 months), and secondary outcomes common to the individual trials. As a sensitivity
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18th UK Stroke Forum conference, 4 - 6 December 2023, ICC Birmingham, UK Int. J. Stroke (IF 6.7) Pub Date : 2024-03-16
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Safety and Efficacy of Tight Versus Loose Glycemic Control in Acute Stroke Patients: A Meta-Analysis of Randomized Controlled Trials Int. J. Stroke (IF 6.7) Pub Date : 2024-03-13 Shuangzhe Wu, Yuke Mao, Sijia Chen, Peiyan Pan, Huiying Zhang, Siqi Chen, Jue Liu, Donghua Mi
Background:Hyperglycemia is associated with worse stroke outcomes but it is uncertain whether tight glycaemic control during the acute stroke period is associated with a better outcome. We conducted a meta-analysis to compare the effect of tight glycemic control versus loose glycemic control in the acute phase of stroke patients.Methods:A literature search was performed to identify randomized controlled
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Sensitivity of the Boston Criteria Version 2.0 in Dutch-Type Hereditary Cerebral Amyloid Angiopathy Int. J. Stroke (IF 6.7) Pub Date : 2024-03-06 Reinier van der Zwet, Emma Koemans, Sabine Voigt, Rosemarie van Dort, Ingeborg Rasing, Kanishk Kaushik, Thijs van Harten, Manon Schipper, Gisela M Terwindt, Thijs van Osch, Marianne AA van Walderveen, Ellis van Etten, Marieke Wermer
Background and aim:The revised Boston criteria v2.0 for cerebral amyloid angiopathy (CAA) add two radiological markers to the existing criteria: severe visible perivascular spaces in the centrum semiovale and white matter hyperintensities (WMH) in a multispot pattern. This study aims to determine the sensitivity of the updated criteria in mutation carriers with Dutch-type hereditary CAA (D-CAA) in
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Edoxaban for the Treatment of Hypercoagulability and Cerebral Thromboembolism Associated with Cancer: A randomized clinical trial of biomarker targets Int. J. Stroke (IF 6.7) Pub Date : 2024-03-02 Jong-Won Chung, Jaechun Hwang, Hyung Jun Kim, Woo-Keun Seo, Myung-Ju Ahn, Jeffrey L. Saver, Oh Young Bang
Background:This study aimed compare efficacy of edoxaban and enoxaparin upon biomarkers of hypercoagulability in patients with cancer-related embolic stroke of undetermined source (ESUS).Methods:In this open-label, randomized, pilot trial, patients with cancer-related ESUS within 30 days of diagnosis were randomly assigned (1:1) to receive edoxaban (60mg once daily) or enoxaparin (1mg/kg twice daily)
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Association of LDL-cholesterol <1.8 mmol/L and statin use with the recurrence of intracerebral hemorrhage Int. J. Stroke (IF 6.7) Pub Date : 2024-03-02 Tsz Ching LEE, William CY Leung, Chun Ho, Megan WL Chiu, Ian YH Leung, Yuen Kwun Wong, Roxanna K.C. Liu, Christopher HF Sum, David TW Lui, Raymond Cheung, Gilberto Ka Kit Leung, Koon Ho Chan, Kay-Cheong Teo, G K K Lau
Background:Recent intensive LDL-C lowering trials, including FOURIER, ODYSSEY OUTCOMES, and TST trials, have mostly refuted the concern surrounding statin use, low-density lipoprotein cholesterol (LDL-C) lowering, and intracerebral hemorrhage (ICH) risk. However, the results from these trials may not be fully applied to ICH survivors, as the populations studied were mainly patients without prior ICH
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Post-stroke cognitive impairment remains highly prevalent and disabling despite state-of-the-art stroke treatment Int. J. Stroke (IF 6.7) Pub Date : 2024-03-01 Laura Gallucci, Christoph Sperber, Adrian G Guggisberg, Christoph P Kaller, Mirjam R Heldner, Andreas U Monsch, Arsany Hakim, Norbert Silimon, Urs Fischer, Marcel Arnold, Roza Umarova
Background:State-of-the-art stroke treatment significantly reduces lesion size and stroke severity, but it remains unclear whether these therapeutic advances have diminished the burden of post-stroke cognitive impairment (PSCI).Aims:In a cohort of patients receiving modern state-of-the-art stroke care including endovascular therapy, we assessed the frequency of PSCI and the pattern of domain-specific
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Global, Regional, and National Burden of Stroke Attributable to Extreme Low Temperatures, 1990-2019: A Global Analysis Int. J. Stroke (IF 6.7) Pub Date : 2024-03-01 Lue Zhou, Yujie Wei, Yahao Ge, Yapeng Li, Kai Liu, Yuan Gao, Bo Song, Yusheng Li, Daping Zhang, Yacong Bo, Junxi Zhang, Yuming Xu, Xiaoran Duan
Background:Extreme ambient temperatures have been linked to increased risks of stroke morbidity and mortality. However, global estimates of the burden of stroke due to extreme low temperatures are not well-defined.Aims:This study aimed to determine the global burden of stroke due to extreme low temperatures and its spatiotemporal trend from 1990 to 2019.Methods:Based on the Global Burden of Disease
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Reperfusion therapy for stroke: From improving global access, to thrombectomy beyond 24 hours Int. J. Stroke (IF 6.7) Pub Date : 2024-02-29 Hugh S Markus
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Thanks to our reviewers, and editorial board changes Int. J. Stroke (IF 6.7) Pub Date : 2024-02-29 Hugh Markus
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Global, Regional, and National Temporal Trends of Diet-related Ischemic Stroke Mortality and Disability from 1990 to 2019 Int. J. Stroke (IF 6.7) Pub Date : 2024-02-28 Rongguang Ge, Shoujiang You, Danni Zheng, Zengli Zhang, Yongjun Cao, Jie Chang
Background:Stroke is the second-leading cause of death and the third-leading cause of disability in the general population worldwide. However, the changing trend of ischemic stroke burden attributable to various dietary risk factors has not been fully revealed and may contribute to a better understanding of stroke epidemiology.Aims:Our paper aimed to evaluate the temporal trend of diet-related ischemic
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Stroke and High-risk TIAs Outcomes with Reduction of Treatment duration when treatment initiated in Emergency Rooms. (SHORTER-Study) Int. J. Stroke (IF 6.7) Pub Date : 2024-02-24 Adel Alhazzani, Fahad AlAjlan, Ali Alkhathaami, Fahmi Mohammed Al-Senani, Taim Muayqil, Saeed Alghamdi, Ammar AlKawi, Saeed AlZahrani, Majid Bakheet, Mohammed Aljohani, Nouran taher, Abdulkarim Almutairi, Mustafa AlQarni, Sadiq Alsalman, Saeed Alqahtani, Nouf Almansour, Laila Abukhamsin, Amr Mouminah, Nehal Bekheet AlModarra, Gamal Mohamed, Meshal Almodhy, Eid Ali Albogumi, Mohamed AlZawahmah, Abdulrahman
Background:Following TIA and minor stroke, the risk of recurrent stroke can be significantly reduced with short duration dual antiplatelet therapy (DAPT). We wish to investigate if 10 days of DAPT is as effective as 21 days treatment.Study design:This is an open-label, randomized, parallel-group study comparing whether 10 days of DAPT treatment (ASA+Clopidogrel) is non-inferior to 21-day of DAPT. in
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Dabigatran etexilate versus warfarin in cerebral venous thrombosis in Chinese patients (CHOICE-CVT): an open-label, randomized controlled trial Int. J. Stroke (IF 6.7) Pub Date : 2024-02-14 Hongrui Ma, Yaqin Gu, Tingting Bian, Haiqing Song, Zhi Liu, Xunming Ji, Jiangang Duan
Background:The efficacy and safety of dabigatran etexilate for Chinese patients with cerebral venous thrombosis (CVT) has not been well established.Methods:CHOICE-CVT was an exploratory, single-center, randomized, open-label study in the National Center for Neurological Disorders involving Chinese patients with CVT aged 18 to 80 years who were randomly assigned (1:1) to either dabigatran etexilate
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The MAPSTROKE project: a Computational Strategy to Improve Access to Acute Stroke Care Int. J. Stroke (IF 6.7) Pub Date : 2024-02-13 Leonardo Augusto Carbonera, Julián Alejandro Rivillas, Gillian Gordon Perue, LEONARDO da Luz DA LUZ DORNELES, Mateus Boiani, Ana Claudia de Souza, Gisele Sampaio Silva, Márcio Dorn, Sheila Cristina Ouriques Martins
Background:Global access to acute stroke treatment is variable worldwide, with notable gaps in low and middle-income countries (LMIC), especially in rural areas. Ensuring a standardized method for pinpointing the existing regional coverage and proposing potential sites for new stroke centers is essential to change this scenario.Aims:To create and apply computational strategies (CS) to determine optimal
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Telemedical stroke care significantly improves patient outcome in rural areas – long-term analysis of the German NEVAS network. Int. J. Stroke (IF 6.7) Pub Date : 2024-02-13 Ilias Masouris, Lars Kellert, Cauchy Pradhan, Johannes Wischmann, Roman Schniepp, Robert Müller, Leonard Fuhry, Gerhard F Hamann, Thomas Pfefferkorn, Jan Rémi, Florian Schöberl
Background.Comprehensive stroke centers (CSC) offer state-of-the-art stroke care in metropolitan centers. However, in rural areas sufficient stroke expertise is much scarcer. Recently, telemedical stroke networks have offered instant consultation by stroke experts, enabling immediate administration of intravenous thrombolysis (IVT) on-site and decision on thrombectomy. While these immediate decisions
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Efficacy and safety of NeuroEndoscopic Surgery for IntraCerebral Hemorrhage: A randomized, controlled, open-label, blinded endpoint trial (NESICH) Int. J. Stroke (IF 6.7) Pub Date : 2024-01-31 Long Wang, Tengyuan Zhou, Pangbo Wang, Shuixian Zhang, Yi Yin, Lin Chen, Haijun Duan, Na Wu, Hua Feng, Rong Hu
Background:Neuroendoscopy is a minimally invasive procedure for clot evacuation in intracerebral hemorrhage (ICH) which may have advantages compared with open surgical evacuation procedures. The application of neuroendoscopy in ICH has attracted increasing attention in recent years. However, it remains unclear whether it could improve outcomes in patients with ICH.Objective:The aim of this study is
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ANDEXANET ALFA VS NON-SPECIFIC TREATMENTS FOR INTRACEREBRAL HEMORRHAGE IN PATIENTS TAKING FACTOR XA INHIBITORS – INDIVIDUAL PATIENT DATA ANALYSIS OF ANNEXA-4 AND TICH-NOAC Int. J. Stroke (IF 6.7) Pub Date : 2024-01-24 Bernhard Matthias Siepen, Alexandros A Polymeris, Ashkan Shoamanesh, Stuart Connolly, Thorsten Steiner, Sven Poli, Robin Lemmens, Martina Beatrice Goeldlin, Madlaine Müller, Mattia Branca, Janis Rauch, Thomas Meinel, Johannes Kaesmacher, Werner J Z’Graggen, Marcel Arnold, Urs Fischer, Nils Peter, Stefan Engelter, Philippe A Lyrer, David J Seiffge
Background:Data comparing the specific reversal agent andexanet alfa with non-specific treatments in patients with non-traumatic intracerebral hemorrhage (ICH) associated with factor-Xa inhibitor (FXaI) use are scarce.Aim:To determine the association between use of andexanet alfa (compared to non-specific treatments) with rate of hematoma expansion and thromboembolic complications in patients with
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Type of anesthesia for endovascular therapy in acute ischemic stroke: A literature review and meta-analysis Int. J. Stroke (IF 6.7) Pub Date : 2024-01-18 Yitong Jia, Yao Feng, Yanhui Ma, Guang Feng, Na Xu, Meng Li, Miao Liu, Zhen Fan, Tianlong Wang
Background:Endovascular thrombectomy (EVT) has been proven as the standard treatment for acute ischemic stroke (AIS) patients due to large vessel occlusion (LVO). However, the ideal anesthetic strategy during EVT still remains unclear. Therefore, this systematic review and meta-analysis aimed to determine the optimal anesthetic modality for patients with AIS undergoing EVT based on current randomized
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Association between high-resolution magnetic resonance vessel wall imaging characteristics and recurrent stroke in patients with intracranial atherosclerotic steno-occlusive disease: A prospective multicenter study Int. J. Stroke (IF 6.7) Pub Date : 2024-01-17 Weizhuang Yuan, Xiaoyun Liu, Zhongrui Yan, Bo Wu, Baoquan Lu, Beilei Chen, Daishi Tian, Ailian Du, Litao Li, Changyun Liu, Guangzhi Liu, Tao Gong, Zhimin Shi, Feng Feng, Caiyan Liu, Yao Meng, Qianqian Lin, Mingli Li, Wei-Hai Xu
Background:High-resolution magnetic resonance vessel wall imaging (HRMR-VWI) is a promising technique for identifying intracranial vulnerable plaques beyond lumen narrowing. However, the association between HRMR-VWI characteristics and recurrent stroke remains uncertain.Aims:This study aimed to investigate the association between HRMR-VWI characteristics and recurrent ipsilateral stroke in patients
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Variations in the prevalence of atrial fibrillation, and in the strength of its association with ischemic stroke, in countries with different income levels: INTERSTROKE case–control study Int. J. Stroke (IF 6.7) Pub Date : 2024-01-11 Robert Murphy, Albertino Damasceno, Catriona Reddin, Graeme J Hankey, Helle K Iversen, Shahram Oveisgharan, Fernando Lanas, Anna Czlonkowska, Peter Langhorne, Adesola Ogunniyi, Mohammad Wasay, Zvonko Rumboldt, Conor Judge, Aytekin Oguz, Charles Mondo, Yaroslav Winter, Annika Rosengren, Nana Pogosova, Alvaro Avezum, Yongchai Nilanont, Ernesto Penaherrera, Denis Xavier, Patricio Lopez-Jaramillo, Xingyu
Background:The contribution of atrial fibrillation (AF) to the etiology and burden of stroke may vary by country income level.Aims:We examined differences in the prevalence of AF and described variations in the magnitude of the association between AF and ischemic stroke by country income level.Methods:In the INTERSTROKE case–control study, participants with acute first ischemic stroke were recruited
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Diagnosing cancer-associated ischemic stroke: A systematic review of hematological biomarkers Int. J. Stroke (IF 6.7) Pub Date : 2024-01-09 Mai Erritzøe-Jervild, Jonathan Wenstrup, Bjørn Holger Hougaard, Christina Kruuse
Background and aim:Patients suffering from cancer are reported to have an increased risk of ischemic stroke (IS). We aimed to identify cancer-associated biomarkers found to differentiate between IS associated with cancer from those not associated with cancer.Summary of review:We performed a systematic search of PubMed and EMBASE databases according to Preferred Reporting Items for Systematic Reviews
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Stroke Characteristics and Outcomes in Urban Tanzania: Data from the Prospective Lake Zone Stroke Registry. Int. J. Stroke (IF 6.7) Pub Date : 2023-11-30 Sarah Shali Matuja,Joshua Ngimbwa,Lilian Andrew,Jemima Shindika,Goodluck Nchasi,Anna Kasala,Innocent Kitandu Paul,Mary Ndalahwa,Akili Mawazo,Fredrick Kalokola,Patrick Ngoya,Ladius Rudovick,Semvua Kilonzo,Bahati Wajanga,Fabian Massaga,Samuel Kalluvya,Patricia Munseri,Mohamed Mnacho,Kigocha Okeng'o,Henrika Kimambo,Mohamed Manji,Paschal Ruggajo,Tumaini Nagu,Rashid Ali Ahmed,Faheem Sheriff,Karim M Mahawish
BACKGROUND Stroke is a second leading cause of death globally, with an estimated one in four adults suffering a stroke in their lifetime. We aimed to describe the clinical characteristics, quality of care and outcomes in adults with stroke in urban Northwestern Tanzania. METHODS We analyzed de-identified data from a prospective stroke registry from Bugando Medical Center in Mwanza, the second largest
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Identifying the optimal time period for detection of atrial fibrillation after ischaemic stroke and TIA: An updated systematic review and meta-analysis of randomized control trials. Int. J. Stroke (IF 6.7) Pub Date : 2023-11-30 Mrinal Thakur,Ahmed Alsinbili,Rahul Chattopadhyay,Elizabeth A Warburton,Kayvan Khadjooi,Isuru Induruwa
BACKGROUND Atrial fibrillation (AF) is a major risk factor for ischaemic stroke (IS) and transient ischaemic attack (TIA). The timely detection of first-diagnosed or "new" AF (nAF) would prompt a switch from antiplatelets to anticoagulation to reduce the risk of stroke recurrence; however, the optimal timing and duration of rhythm monitoring to detect nAF remains unclear. AIMS We searched MEDLINE,
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Epidemiology and outcomes of intracerebral hemorrhage associated with oral anticoagulation over 10 years in a population-based stroke registry. Int. J. Stroke (IF 6.7) Pub Date : 2023-11-24 Francesca Gabriele,Matteo Foschi,Francesco Conversi,Davide Ciuffini,Federica De Santis,Berardino Orlandi,Federico De Santis,Raffaele Ornello,Simona Sacco
BACKGROUND Recent years have seen a change in the use of anticoagulants in the general population due to both the availability of direct oral anticoagulants (DOACs) as an alternative to vitamin K antagonists (VKAs), and the increased detection of atrial fibrillation. It is important to have updated epidemiological data to understand how this change is impacting on the occurrence and outcome of intracerebral
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Prognostic value of recanalization attempts in endovascular therapy for M2 segment middle cerebral artery occlusions. Int. J. Stroke (IF 6.7) Pub Date : 2023-11-22 Laurens Winkelmeier,Christian Heitkamp,Tobias D Faizy,Gabriel Broocks,Helge Kniep,Lukas Meyer,Maxim Bester,Caspar Brekenfeld,Maximilian Schell,Uta Hanning,Götz Thomalla,Jens Fiehler,Fabian Flottmann
BACKGROUND There is growing evidence suggesting efficacy of endovascular therapy for M2 occlusions of the middle cerebral artery. More than one recanalization attempt is often required to achieve successful reperfusion in M2 occlusions, associated with general concerns about the safety of multiple maneuvers in these medium vessel occlusions. AIM The aim of this study was to investigate the association
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Association of multimorbidity with mortality after stroke stratified by age, severity, etiology, and prior disability. Int. J. Stroke (IF 6.7) Pub Date : 2023-11-22 Matthew B Downer,Ramon Luengo-Fernandez,Lucy E Binney,Sergei Gutnikov,Louise E Silver,Aubretia McColl,Peter M Rothwell
BACKGROUND Multimorbidity is common in patients with stroke and is associated with increased medium- to long-term mortality, but its value for clinical decision-making and case-mix adjustment will depend on other factors, such as age, stroke severity, etiological subtype, prior disability, and vascular risk factors. AIMS In the absence of previous studies, we related multimorbidity to long-term post-stroke
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Sleep disorders as both risk factors for, and a consequence of, stroke: A narrative review. Int. J. Stroke (IF 6.7) Pub Date : 2023-11-20 Lukas Mayer-Suess,Abubaker Ibrahim,Kurt Moelgg,Matteo Cesari,Michael Knoflach,Birgit Högl,Ambra Stefani,Stefan Kiechl,Anna Heidbreder
BACKGROUND AND PURPOSE Sleep disorders are increasingly implicated as risk factors for stroke, as well as a determinant of stroke outcome. They can also occur secondary to the stroke itself. In this review, we describe the variety of different sleep disorders associated with stroke and analyze their effect on stroke risk and outcome. METHODS A search term-based literature review ("sleep," "insomnia
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Chronic ischemic lesions and presence of patent foramen ovale in young adults with embolic stroke of undetermined source - Results of the Young ESUS Patient Registry. Int. J. Stroke (IF 6.7) Pub Date : 2023-11-19 Thomas Raphael Meinel,Kate Tsiplova,Amanda Taylor,Elena Meseguer,Karl Georg Häusler,Robert G Hart,Marcel Arnold,Kanjana S Perera
BACKGROUND Chronic ischemic lesions (CIL) are frequent findings in patients with acute ischemic stroke, but their phenotypes and relevance in young adults with embolic stroke of undetermined source (Y-ESUS) remains uncertain. We aimed to compare Y-ESUS patients with CIL to those without CIL and assessed the association of CIL and its phenotypes with the presence of patent foramen ovale (PFO). METHODS
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Association of circulating CD34+ cells level and prognosis after ischemic stroke. Int. J. Stroke (IF 6.7) Pub Date : 2023-11-18 Takafumi Mizuno,Takao Hoshino,Kentaro Ishizuka,Sono Toi,Shuntaro Takahashi,Sho Wako,Satoko Arai,Kazuo Kitagawa
BACKGROUND CD34 is a transmembrane phosphoglycoprotein and a marker of hematopoietic and nonhematopoietic stem/progenitor cells. In experimental studies, CD34+ cells are rich sources of endothelial progenitor cells and can promote neovascularization and endothelial repair. The potential role of CD34+ cells in stroke patients remains unclear. AIMS We aimed to assess the prognostic effect of circulating
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Lung cancer is associated with acute ongoing cerebral ischemia. Int. J. Stroke (IF 6.7) Pub Date : 2023-11-18 Jonathan Naftali,Rani Barnea,Ruth Eliahou,Keshet Pardo,Assaf Tolkovsky,Meital Adi,Vadim Khasminsky,Walid Saliba,Sivan Bloch,Guy Raphaeli,Avi Leader,Eitan Auriel
BACKGROUND AND OBJECTIVES Cerebral microinfarcts (CMI) are the most common type of brain ischemia, however they are extremely rare in the general population. CMI can be detected by Magnetic resonance diffusion-weighted imaging (MRI-DWI) only for a very short period of approximately 2 weeks after their formation, and are associated with an increased stroke risk and cognitive impairment. We aimed to
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Effect of abnormal body weight on mortality and functional recovery in adults after stroke: An umbrella review. Int. J. Stroke (IF 6.7) Pub Date : 2023-11-18 Stephanie A Holland,Ian Wellwood,Suzanne Kuys
BACKGROUND Several published systematic reviews have drawn conflicting conclusions on the effect of abnormal body weight (i.e. being underweight, overweight or obese) on outcomes following stroke. The 'obesity paradox' seen in several diseases (wherein obesity, often associated with mortality and morbidity, appears to be protective and improve outcomes) may be evident after stroke, but inconsistent
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Cerebral Microbleeds and Asundexian in Non-cardioembolic Ischemic Stroke: Secondary Analyses of the PACIFIC-STROKE Randomized Trial. Int. J. Stroke (IF 6.7) Pub Date : 2023-11-10 Pargol Balali,Robert G Hart,Eric Edward Smith,Feryal Saad,Pablo Colorado,Robin Lemmens,Gian Marco De Marchis,Valeria Caso,Lizhen Xu,Laura Heenan,Stuart Connolly,Hardi Mundl,Ashkan Shoamanesh
BACKGROUND AND AIMS Cerebral microbleeds are MRI markers of hemorrhage-prone cerebral small-vessel disease that predict future risk of ischemic stroke and intracranial hemorrhage (ICrH). There exists concerns about the net benefit of antithrombotic therapy in patients with microbleeds. We aimed to investigate the effects of an oral factor-XIa inhibitor (asundexian), that is hypothesized to inhibit
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Long-term stroke risk in moyamoya disease. Int. J. Stroke (IF 6.7) Pub Date : 2023-11-10 Peter Birkeland,Victoria Hansen,Vinosha Tharmabalan,Jens Lauritsen,Troels Halfeld Nielsen,Thomas Clement Truelsen,Sverre Rosenbaum,Paul von Weitzel-Mudersbach
BACKGROUND Moyamoya disease is considered a progressive disease with an ongoing risk of recurrent stroke. However, there is a lack of long-term observational data to quantify the extent of the stroke risk. METHODS This study aimed to provide insight into the long-term stroke risk in MMD and explore possible risk factors for stroke. Records from all patients diagnosed with MMD in 13 clinical departments
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Prevalence, patterns, and predictors of patient-reported non-motor outcomes at 30 days after acute stroke: prospective observational hospital cohort study. Int. J. Stroke (IF 6.7) Pub Date : 2023-11-10 Hatice Ozkan,Gareth Ambler,Gargi Banerjee,Simone Browning,Alex P Leff,Nick S Ward,Robert Simister,David Werring
BACKGROUND Adverse non-motor outcomes are common after acute stroke and likely to substantially affect quality of life, yet few studies have comprehensively assessed their prevalence, patterns, and predictors across multiple health domains. AIMS We aim to identify the prevalence, patterns and the factors associated with non-motor outcomes 30 days after stroke. METHODS This prospective observational
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Endovascular treatment for acute ischemic stroke beyond the 24-h time window: Selection by target mismatch profile. Int. J. Stroke (IF 6.7) Pub Date : 2023-11-03 Trung Quoc Nguyen,Mai Hoang Tran,Hai Ngoc Phung,Khang Vinh Nguyen,Hang T Minh Tran,Silke Walter,Dinh C Bao Hoang,Binh Nguyen Pham,Anh Le Tuan Truong,Vu Thanh Tran,Thanh N Nguyen,An Le Pham,Huy-Thang Nguyen
INTRODUCTION Endovascular treatment for acute ischemic stroke patients with large vessel occlusion (LVO) has been established as a promising clinical intervention within a late time window of 6-24 h after symptom onset. Patients with slow progression, however, may still benefit from endovascular treatment beyond the 24-h time window (very late window). AIM The aim of this study is to report insight
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Is telestroke more effective than conventional treatment for acute ischemic stroke? A systematic review and meta-analysis of patient outcomes and thrombolysis rates. Int. J. Stroke (IF 6.7) Pub Date : 2023-10-27 Ahmed Mohamed,Salah Elsherif,Brittney Legere,Nida Fatima,Ashfaq Shuaib,Maher Saqqur
BACKGROUND Telestroke systems operate through remote communication, providing distant stroke evaluation through expert healthcare providers. The aim of this study was to assess whether the implementation of a telestroke system influenced stroke treatment outcomes in acute ischemic stroke (AIS) patients compared with conventional in-person treatment. AIMS The study group evaluated multiple studies from
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Targeting inflammation to reduce recurrent stroke. Int. J. Stroke (IF 6.7) Pub Date : 2023-10-19 Annaelle Zietz,Sarah Gorey,Peter J Kelly,Mira Katan,John J McCabe
BACKGROUND Approximately one in four stroke patients suffer from recurrent vascular events, underlying the necessity to improve secondary stroke prevention strategies. Immune mechanisms are causally associated with coronary atherosclerosis. However, stroke is a heterogeneous disease and the relative contribution of inflammation across stroke mechanisms is not well understood. The optimal design of
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Global Stroke Statistics 2023: Availability of reperfusion services around the world. Int. J. Stroke (IF 6.7) Pub Date : 2023-10-18 Joosup Kim,Muideen T Olaiya,Deidre Anne De Silva,Bo Norrving,Jackie Bosch,Diana Aguiar de Sousa,Hanne Christensen,Anna Ranta,Geoffrey Donnan,Valery L Feigin,Sheila Martins,Lee Schwamm,David Werring,George Howard,Mayowa Owolabi,Jeyaraj Durai Pandian,Robert Mikulik,Tharshanah Thayabaranathan,Dominique Cadilhac
BACKGROUND Disparities in the availability of reperfusion services for acute ischaemic stroke are considerable globally, and require urgent attention. Contemporary data on the availability of reperfusion services in different countries provide the necessary evidence to prioritise where access to acute stroke treatment is needed. AIMS To provide a snapshot of published literature on the provision of
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Duration of dual-antiplatelet therapy after stent-assisted coil for unruptured intracranial aneurysm: A nationwide cohort study. Int. J. Stroke (IF 6.7) Pub Date : 2023-10-18 Minyoul Baik,Jimin Jeon,Seok-Jae Heo,Joonsang Yoo,Jinkwon Kim
BACKGROUND Stent-assisted coil (SAC) is increasingly used to treat unruptured intracranial aneurysm (UIA). However, the optimal duration of dual-antiplatelet therapy (DAPT) after SAC insertion remains unknown. AIM To assess the time-dependent effect of DAPT on the risk of ischemic and hemorrhagic complications after SAC. METHODS This is a retrospective cohort study among patients with UIA treated with
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Changes in anticoagulation practice in subjects admitted with stroke associated with atrial fibrillation, following introduction of direct oral anticoagulants over 2013-2021. Int. J. Stroke (IF 6.7) Pub Date : 2023-10-14 Joseph Harbison,Joan McCormack,Olga Brych,Ronan Collins,Niamh O'Connell,Mary Randles,Cormac Kennedy,Peter J Kelly,Tim Cassidy
BACKGROUND The adoption of direct oral anticoagulants (DOACs) has changed practice in prevention of stroke in atrial fibrillation (AF). We used Irish data national data on stroke and anticoagulation therapy over 9 years to investigate changes in anticoagulation practice and potential consequences on stroke prevalence and thrombolysis. METHODS AF, anticoagulation, thrombolysis, and stroke data from
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Control intervention design for preclinical and clinical trials: Consensus-based core recommendations from the third Stroke Recovery and Rehabilitation Roundtable. Int. J. Stroke (IF 6.7) Pub Date : 2023-10-12 Kathryn S Hayward,Emily J Dalton,Jessica Barth,Marian Brady,Leora R Cherney,Leonid Churilov,Andrew N Clarkson,Jesse Dawson,Sean P Dukelow,Peter Feys,Maree Hackett,Steve R Zeiler,Catherine E Lang
Control comparator selection is a critical trial design issue. Preclinical and clinical investigators who are doing trials of stroke recovery and rehabilitation interventions must carefully consider the appropriateness and relevance of their chosen control comparator as the benefit of an experimental intervention is established relative to a comparator. Establishing a strong rationale for a selected
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Standardized measurement of balance and mobility post-stroke: Consensus-based core recommendations from the third Stroke Recovery and Rehabilitation Roundtable. Int. J. Stroke (IF 6.7) Pub Date : 2023-10-12 Tamaya Van Criekinge,Charlotte Heremans,Jane Burridge,Judith E Deutsch,Ulrike Hammerbeck,Kristen Hollands,Suruliraj Karthikbabu,Jan Mehrholz,Jennifer L Moore,Nancy M Salbach,Jonas Schröder,Janne M Veerbeek,Vivian Weerdesteyn,Karen Borschmann,Leonid Churilov,Geert Verheyden,Gert Kwakkel
BACKGROUND Mobility is a key priority for stroke survivors. Worldwide consensus of standardized outcome instruments for measuring mobility recovery after stroke is an essential milestone to optimize the quality of stroke rehabilitation and recovery studies and to enable data synthesis across trials. METHODS Using a standardized methodology, which involved convening of 13 worldwide experts in the field
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A translational roadmap for transcranial magnetic and direct current stimulation in stroke rehabilitation: Consensus-based core recommendations from the third stroke recovery and rehabilitation roundtable. Int. J. Stroke (IF 6.7) Pub Date : 2023-10-12 Jodi D Edwards,Adan Ulises Dominguez-Vargas,Charlotte Rosso,Meret Branscheidt,Lisa Sheehy,Fanny Quandt,Simon A Zamora,Melanie K Fleming,Valentina Azzollini,Ronan A Mooney,Charlotte J Stagg,Chiristian Gerloff,Simone Rossi,Leonardo G Cohen,Pablo Celnik,Michael A Nitsche,Cathrin M Buetefisch,Numa Dancause
BACKGROUND AND AIMS The purpose of this Third Stroke Recovery and Rehabilitation Roundtable (SRRR3) was to develop consensus recommendations to address outstanding barriers for the translation of preclinical and clinical research using the non-invasive brain stimulation (NIBS) techniques Transcranial Magnetic Stimulation (TMS) and Transcranial Direct Current Stimulation (tDCS) and provide a roadmap
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Clinical, imaging, and management features of symptomatic carotid web: Insight from CAROWEB registry. Int. J. Stroke (IF 6.7) Pub Date : 2023-10-09 Stephane Olindo,Nicolas Gaillard,Nicolas Chausson,Cedric Turpinat,Cyril Dargazanli,Quentin Bourgeois-Beauvais,Aissatou Signate,Julien Joux,Mehdi Mejdoubi,Michel Piotin,Mickael Obadia,Jean-Philippe Desilles,François Delvoye,Quentin Holay,Benjamin Gory,Sébastien Richard,Christian Denier,Emmanuelle Robinet-Borgomano,Xavier Carle,Hubert Desal,Benoit Guillon,Alain Viguier,Matthias Lamy,Fernando Pico,Anne
BACKGROUND Although carotid web (CaW) is increasingly diagnosed as a cause of cryptogenic stroke, data are still limited to monocentric small sample cohort. To broaden knowledge on symptomatic CaW, CAROWEB registry has been recently implemented. AIMS In a large cohort of symptomatic CaW patients, we described epidemiologic characteristics, admission clinical and imaging features, and the current management
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Safety and efficacy of tenecteplase versus alteplase in stroke patients with carotid tandem lesions: Results from the AcT trial. Int. J. Stroke (IF 6.7) Pub Date : 2023-10-06 Fouzi Bala,Mohammed Almekhlafi,Nishita Singh,Ibrahim Alhabli,Ayoola Ademola,Shelagh B Coutts,Yan Deschaintre,Houman Khosravani,Ramana Appireddy,Francois Moreau,Stephen Phillips,Gord Gubitz,Aleksander Tkach,Luciana Catanese,Dar Dowlatshahi,George Medvedev,Jennifer Mandzia,Aleksandra Pikula,Jay Shankar,Heather Williams,Thalia S Field,Alejandro Manosalva,Muzaffar Siddiqui,Atif Zafar,Oje Imoukhoude,Gary
BACKGROUND Carotid tandem lesions ((TL) ⩾70% stenosis or occlusion) account for 15-20% of acute stroke with large vessel occlusion. AIMS We investigated the safety and efficacy of intravenous tenecteplase (0.25 mg/kg) versus intravenous alteplase (0.9 mg/kg) in patients with carotid TL. METHODS This is a substudy of the alteplase compared with the tenecteplase trial. Patients with ⩾70% stenosis of