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Global research trends and emerging opportunities for integrin adhesion complexes in cardiac repair: a scientometric analysis Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-18 Jiayu Lv, Zhenyue Fu, Haoran Zheng, Qingqiao Song
ObjectiveCardiac regenerative medicine has gained significant attention in recent years, and integrins are known to play a critical role in mediating cardiac development and repair, especially after an injury from the myocardial infarction (MI). Given the extensive research history and interdisciplinary nature of this field, a quantitative retrospective analysis and visualization of related topics
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Natural products in atherosclerosis therapy by targeting PPARs: a review focusing on lipid metabolism and inflammation Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-18 Yan Zhang, Xue-Ying Zhang, Shan-Rui Shi, Chao-Nan Ma, Yun-Peng Lin, Wen-Gang Song, Shou-Dong Guo
Inflammation and dyslipidemia are critical inducing factors of atherosclerosis. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors and control the expression of multiple genes that are involved in lipid metabolism and inflammatory responses. However, synthesized PPAR agonists exhibit contrary therapeutic effects and various side effects in atherosclerosis
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Predictive value of the inconsistency between the residual and post-PCI QFR for prognosis in PCI patients Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-17 Lihua Chen, Jiaxin Zhong, Ruijin Hong, Yuxiang Chen, Beilei Li, Laicheng Wang, Yuanming Yan, Lianglong Chen, Qin Chen, Yukun Luo
IntroductionTo investigate the prognostic value of the consistency between the residual quantitative flow ratio (QFR) and postpercutaneous coronary intervention (PCI) QFR in patients undergoing revascularization.MethodsThis was a single-center, retrospective, observational study. All enrolled patients were divided into five groups according to the ΔQFR (defined as the value of the post-PCI QFR minus
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Effects of high-intensity interval exercise on arterial stiffness in individuals at risk for cardiovascular disease: a meta-analysis Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-17 Ping Luo, Ruoshan Wu, Weifeng Gao, Weiyi Yan, Ruixue Wang, Yufang Ye
ObjectiveThe purpose of this meta-analysis was to investigate the effect of high-intensity interval training (HIIT) on arterial stiffness (AS) and vascular function in persons at high risk of cardiovascular disease (CVD).MethodsWe conducted a comprehensive search of randomized controlled trials (RCTs) published in electronic databases (PubMed, Web of Science, Cochrane, Embase, and Ebsco) since their
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Longitudinal change of serum exosomal miR-186-5p estimates major adverse cardiac events in acute myocardial infarction patients receiving percutaneous coronary intervention Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-17 Lingyun Ren, Wei Liu, Shanshan Chen, Haibo Zeng
ObjectiveOur recently published study discovers that exosomal microRNA (miR)-186-5p promotes vascular smooth muscle cell viability and invasion to facilitate atherosclerosis. This research aimed to explore the prognostic implication of serum exosomal miR-186-5p in acute myocardial infarction (AMI) patients receiving percutaneous coronary intervention (PCI).MethodsOne hundred and fifty AMI patients
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Molecular mechanisms and potential therapeutic targets in the pathogenesis of hypertension in visceral adipose tissue induced by a high-fat diet Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-16 Zhenyang Su, Jin-Yu Sun, Min Gao, Wei Sun, Xiangqing Kong
BackgroundHypertension (HTN) presents a significant global public health challenge with diverse causative factors. The accumulation of visceral adipose tissue (VAT) due to a high-fat diet (HFD) is an independent risk factor for HTN. While various studies have explored pathogenic mechanisms, a comprehensive understanding of impact of VAT on blood pressure necessitates bioinformatics analysis.MethodsDatasets
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A Case Report of Mycoplasma pneumoniae-induced fulminant myocarditis in a 15-year-old male leading to cardiogenic shock and electrical storm Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-16 Chengrui Zhu, Bo Hu, Xiaotong Li, Weiying Han, Yingjian Liang, Xiaochun Ma
Mycoplasma pneumoniae (M. pneumoniae) is a well-recognized pathogen primarily associated with respiratory tract infections. However, in rare instances, it can lead to extrapulmonary manifestations, including myocarditis. We present a case of a 15-year-old male who developed fulminant myocarditis, cardiogenic shock, and cardiac electrical storm attributed to M. pneumoniae infection. He underwent a combination
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Signal-averaged electrocardiography as a noninvasive tool for evaluating the ventricular substrate in patients with nonischemic cardiomyopathy: reassessment of an old tool Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-16 Dinh Son Ngoc Nguyen, Chin-Yu Lin, Fa-Po Chung, Ting-Yung Chang, Li-Wei Lo, Yenn-Jiang Lin, Shih-Lin Chang, Yu-Feng Hu, Ta-Chuan Tuan, Tze-Fan Chao, Jo-Nan Liao, Ling Kuo, Chih-Min Liu, Shin-Huei Liu, Cheng-I Wu, Ming-Jen Kuo, Guan-Yi Li, Yu-Shan Huang, Shang-Ju Wu, Yoon Kee Siow, Jose Antonio L. Bautista, Dat Tran Cao, Shih-Ann Chen
IntroductionSignal-averaged electrocardiography (SAECG) provides diagnostic and prognostic information regarding cardiac diseases. However, its value in other nonischemic cardiomyopathies (NICMs) remains unclear. This study aimed to investigate the role of SAECG in patients with NICM.Methods and resultsThis retrospective study included consecutive patients with NICM who underwent SAECG, biventricular
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Atrial fibrillation and COVID-19: an analysis of the ambulatory database Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-16 Zhanna M. Sizova, Valeria L. Zakharova, Natalya N. Shindryaeva, Natalia I. Lapidus, Mariya V. Melnik, Evgenia V. Shikh, Ludmila Y. Grebenshchikova, Alexandra V. Beloborodova, Ivan P. Polovikov
Atrial fibrillation (AF) is the most common heart rhythm disorder in clinical practice. It worsens the quality of life of patients, leads to an increase in the mortality rate because of its association with a high risk of thromboembolic complications. The current pandemic of a new coronavirus infection, which began in March 2020, was marked by an increase in cardiovascular diseases, including an increase
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The relative potential contribution of volume load and vascular mechanisms to hypertension in non-dialysis and dialysis chronic kidney disease patients Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-15 Grace Tade, Hon-Chun Hsu, Chanel Robinson, Noluntu Dlongolo, Gloria Teckie, Ahmed Solomon, Patrick Hector Dessein
BackgroundHypertension is highly prevalent and particularly difficult to treat adequately in patients with chronic kidney disease (CKD). The relative contribution of volume overload and vascular mechanisms to blood pressure measures in CKD and whether these effects differ in non-dialysis compared to dialysis patients is unknown.MethodsWe determined the potential impact of volume load (stroke volume)
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Diagnostic and prognostic value of angiography-derived index of microvascular resistance: a systematic review and meta-analysis Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-15 Dayang Wang, Xiaoming Li, Wei Feng, Hufang Zhou, Wenhua Peng, Xian Wang
BackgroundThe angiography-derived index of microvascular resistance (A-IMR) is a novel tool for diagnosing coronary microvascular dysfunction (CMD) addressing limitation of unavailability. However, the clinical value of A-IMR remains controversial.MethodsA systematic review and meta-analysis was conducted. PubMed, EMBASE, Cochrane Library and Web of Science were searched for relevant studies. Studies
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Electrocardiographic approach strategies in patients with Parkinson disease treated with deep brain stimulation Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-12 Carlos Rafael Sierra-Fernández, Luis Rodrigo Garnica-Geronimo, Alejandra Huipe-Dimas, Jorge A. Ortega-Hernandez, María Alejandra Ruiz-Mafud, Amin Cervantes-Arriaga, Ana Jimena Hernández-Medrano, Mayela Rodríguez-Violante
Deep brain stimulation (DBS) is an interdisciplinary and reversible therapy that uses high-frequency electrical stimulation to correct aberrant neural pathways in motor and cognitive neurological disorders. However, the high frequency of the waves used in DBS can interfere with electrical recording devices (e.g., electrocardiogram, electroencephalogram, cardiac monitor), creating artifacts that hinder
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Effect of orthostatic hypotension on long-term prognosis of elderly patients with stable coronary artery disease: a retrospective cohort study Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-12 Jiaman Hu, Jianing Chi, Hua Cai, Ningxia Wu, Pengfei Li, Yuekang Huang, Cailong Lin, Yingying Lai, Jianyu Huang, Weihua Li, Peng Su, Min Li, Zhongqiu Lin, Lin Xu
BackgroundThe long-term prognosis of patients with stable coronary artery disease (CAD) combined with orthostatic hypotension (OH) has rarely been reported. This research was designed to examine whether OH increases the risk of all-cause mortality and cardiovascular death among patients with stable CAD.MethodsWe retrospectively analyzed retired military personnel over 65 years of age who were hospitalized
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Neurocognitive function in procedures correcting severe aortic valve stenosis: patterns and determinants Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-12 L. Ranucci, L. Brischigiaro, V. Mazzotta, M. Anguissola, L. Menicanti, F. Bedogni, M. Ranucci
BackgroundNeurocognitive changes occurring after a surgical aortic valve replacement (SAVR) or transcatheter aortic valve implantation (TAVI) procedure for the correction of severe aortic stenosis (AS) have not been widely addressed and, if addressed, have produced conflicting results. The purpose of this study is to identify the pre-procedural neurocognitive pattern and its determinants in a setting
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Sudden death associated with delayed cardiac rupture: case report and literature review Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-12 Lopsong Tinzin, Xuefei Gao, Hui Li, Shuquan Zhao
Cardiac injury plays a critical role in the process of thoracic trauma-related fatal outcomes. Historically, most patients who suffer a cardiac rupture typically die at the scene of occurrence or in the hospital, despite prompt medical intervention. Delayed cardiac rupture, although rare, may occur days after the initial injury and cause sudden unexpected death. Herein, we present the clinical details
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New-onset atrial fibrillation following arteriovenous fistula increases adverse clinical events in dialysis patients with end-stage renal disease Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-12 Wenhui Song, Lizhou Wu, Chong Sun, Xianglei Kong, Haiyan Wang
BackgroundEnd-stage renal disease (ESRD) patients have a high potential cardiovascular burden, and cardiovascular disease (CVD) is the leading cause of death in maintenance haemodialysis (MHD) patients. Arteriovenous fistula (AVF) is the preferred vascular access for MHD patients, but AVF significantly affects the haemodynamics of the cardiovascular system, leading to or exacerbating CVD, including
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Case Report: An unusual case of a transposition of the great arteries with a double aortic arch: a highly complex fetal diagnosis with an unpredictable outcome Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-12 M. Masci, A. Missineo, C. M. Campanale, P. Moras, M. C. Colucci, L. Pasquini, A. Toscano
Published data estimate the prevalence of the vascular ring at approximately 7 per 10,000 live births. The association of a double aortic arch with a D-transposition of the great arteries has been rarely described in the literature. In this study, we report the prenatal diagnosis of a 28-year-old woman. A fetal echocardiography at a gestational age of 24 weeks + 6 days showed a D-transposition of the
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Treatment options for isolated aortic valve insufficiency: a review Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-11 Salem Argaw, Nasim Azizgolshani, David Blitzer, Hiroo Takayama, Isaac George, Luigi Pirelli
Aortic insufficiency (AI) is a valvular disease with increasing prevalence in older patients. The modern era provides numerous options for the management of AI which is explored here. Traditional interventions included aortic valve replacement with either mechanical or bioprosthetic aortic valves. While the former is known for its durability, it has grown out of favor due to the potential complications
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A case report of successful rescue using veno-arterial extracorporeal membrane oxygenation: managing cerebral-cardiac syndrome Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-11 Zheng Wang, Qi-Feng Zhang, Miao Guo, Xiao-Xia Qi, Xiao-Hui Xing, Gang Li, Shuang-Long Zhang
IntroductionThe presence of cerebral-cardiac syndrome, wherein brain diseases coincide with heart dysfunction, significantly impacts patient prognosis. In severe instances, circulatory failure may ensue, posing a life-threatening scenario necessitating immediate life support measures, particularly effective circulatory support methods. The application of extracorporeal membrane oxygenation (ECMO) is
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A causal association between amyotrophic lateral sclerosis and atrial fibrillation: a two-sample Mendelian randomization study Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-11 Yiren Yao, Hongyang Liu, Yang Gu, Xiaojin Xu, Xiwen Zhang
ObjectivesTo look into the connection between amyotrophic lateral sclerosis (ALS) and atrial fibrillation (AF) using Mendelian randomization (MR).MethodsTwo-sample MR was performed using genetic information from genome-wide association studies (GWAS). Genetic variants robustly associated with ALS and AF were used as instrumental variables. GWAS genetic data for ALS (n = 138,086, ncase = 27,205) and
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Interferons and interferon-related pathways in heart disease Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-11 Duc Tin Tran, Sri Nagarjun Batchu, Andrew Advani
Interferons (IFNs) and IFN-related pathways play key roles in the defence against microbial infection. However, these processes may also be activated during the pathogenesis of non-infectious diseases, where they may contribute to organ injury, or function in a compensatory manner. In this review, we explore the roles of IFNs and IFN-related pathways in heart disease. We consider the cardiac effects
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Prevalence of uncontrolled hypertension and contributing factors in Ethiopia: a systematic review and meta-analysis Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-10 Mengistie Yirsaw Gobezie, Minimize Hassen, Nuhamin Alemayehu Tesfaye, Tewodros Solomon, Mulat Belete Demessie, Teklehaimanot Fentie Wendie, Getachew Tadesse, Tesfaye Dessale Kassa, Fentaw Tadese Berhe
BackgroundUncontrolled hypertension (HTN) is a major risk factor for cardiovascular and cerebrovascular disease. The prevalence of HTN in the Ethiopian adult population is almost 20%.This study aimed to determine the prevalence of uncontrolled HTN and its contributing factors among patients with HTN in Ethiopia undergoing treatment.MethodsElectronic bibliographic databases such as PubMed, Google Scholar
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Systematic review of cardiovascular neurocristopathy—contemporary insights and future perspectives Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-10 Osama Soliman, Yogesh Acharya, Martine Gilard, Garry Duffy, William Wijns, Venkatesh Kannan, Sherif Sultan
IntroductionNeural crest cells (NCCs) are multipotent and are attributed to the combination of complex multimodal gene regulatory mechanisms. Cardiac neural crest (CNC) cells, originating from the dorsal neural tube, are pivotal architects of the cardio-neuro-vascular domain, which orchestrates the embryogenesis of critical cardiac and vascular structures. Remarkably, while the scientific community
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Time course of cardiac rupture after acute myocardial infarction and comparison of clinical features of different rupture types Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-10 Chendi Liang, Xiaoxia Wang, Peng Yang, Ru Zhao, Li Li, Zhixin Wang, Yanqing Guo
ObjectiveThis study aimed to investigate the time course of cardiac rupture (CR) after acute myocardial infarction (AMI) and the differences among different rupture types.MethodWe retrospectively analyzed 145 patients with CR after AMI at Shanxi Cardiovascular Hospital from June 2016 to September 2022. Firstly, according to the time from onset of chest pain to CR, the patients were divided into early
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Comparison of infection and complication rates associated with transvenous vs. subcutaneous defibrillators in patients with stage 4 chronic kidney disease: a multicenter long-term retrospective follow-up Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-10 Fabian Schiedat, Benjamin Meuterodt, Magnus Prull, Assem Aweimer, Michael Gotzmann, Stephen O’Connor, Christian Perings, Johannes Korth, Thomas Lawo, Ibrahim El-Battrawy, Christoph Hanefeld, Andreas Mügge, Axel Kloppe
BackgroundPatients with progressive chronic kidney disease (CKD) are at higher risk of infections and complications from cardiac implantable electronic devices (CIED). In patients with a primary or secondary prophylactic indication, implantable cardiac defibrillators (ICD) can prevent sudden cardiac deaths (SCD). We retrospectively compared transvenous-ICD (TV-ICD) and intermuscularly implanted subcutaneous-ICD
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Ductal stenting vs. surgical shunting in late presenting duct-dependent pulmonary circulation: a single-center experience Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-09 Radityo Prakoso, Christine Nathalina Sinaga Simanjorang, Yovi Kurniawati, Brian Mendel, Budi Rahmat, Rita Zahara, Estu Rudiktyo, Damba Dwisepto Aulia Sakti, Renan Sukmawan
IntroductionPDA stenting is an option to mBTT shunt for younger patients; nevertheless, few reports of this palliative approach have been made for the late presenter population, especially for patients who are older than 30 days but under 5 years. This study aimed to evaluate the clinical result and intra-hospital costs of ductal stenting in late-presenting patients in comparison to surgical shunting
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Five-year outcomes of double kissing mini-culotte stenting vs. mini-culotte stenting using drug-eluting stents for the treatment of true coronary bifurcation lesions Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-09 Sheng Tu, Linlin Zhang, Qingqing Tian, Fudong Hu, Ying Wang, Lianglong Chen
ObjectiveThis study aimed to compare the clinical outcomes of double kissing mini-culotte (DKMC) stenting with those of mini-culotte (MC) stenting in treating patients with true coronary bifurcation lesions (CBLs) in the clinical real world.MethodsThis retrospective observational cohort study included 180 consecutive patients with true CBLs (Medina type 1,1,1; 1,0,1; 0,1,1). All eligible patients underwent
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Serum albumin levels and risk of atrial fibrillation: a Mendelian randomization study Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-09 Bohang Chen, Chuqiao Wang, Wenjie Li
ObjectiveAlthough several observational studies have linked serum albumin to cardiovascular disease and considered it as an important biomarker, little is known about whether increasing or maintaining serum albumin levels can effectively improve the prognosis of patients with atrial fibrillation. Therefore, this study aims to further explore the causal relationship between serum albumin and atrial
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Chronic lead exposure and burden of cardiovascular disease during 1990–2019: a systematic analysis of the global burden of disease study Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-09 Peizhu Dang, Manyun Tang, Heze Fan, Junjun Hao
BackgroundCardiovascular diseases (CVD) are the leading causes of death and disability worldwide. Lead exposure is an important risk factor for CVD. In our study, we aimed to estimate spatial and temporal trends in the burden of cardiovascular disease associated with chronic lead exposure.MethodsThe data collected for our study were obtained from Global Burden of Disease (GBD) study 2019 and analyzed
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A history of cardiovascular magnetic resonance imaging in clinical practice and population science Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-08 Mihir M. Sanghvi, João A. C. Lima, David A. Bluemke, Steffen E. Petersen
Cardiovascular magnetic resonance (CMR) imaging has become an invaluable clinical and research tool. Starting from the discovery of nuclear magnetic resonance, this article provides a brief overview of the key developments that have led to CMR as it is today, and how it became the modality of choice for large-scale population studies.
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The causal relationship between obesity, obstructive sleep apnea and atrial fibrillation: a study based on mediated Mendelian randomization Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-08 Tianyu Li, Li Rong, Yanlin Gao, Wei Cheng
BackgroundAtrial fibrillation (AF) is a common cardiac arrhythmia that is associated with obesity and obstructive sleep apnea syndrome (OSA). Obesity and OSA may increase the risk of AF by affecting cardiovascular health.MethodsThe study used the Mendelian randomization (MR) approach, combined with two-sample and multivariable analyses, to assess the relationships between obesity, OSA, and AF. The
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High serum copper as a risk factor of all-cause and cause-specific mortality among US adults, NHANES 2011–2014 Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-08 Xianghui Zeng, Lanqian Zhou, Qingfeng Zeng, Hengqing Zhu, Jianping Luo
BackgroundSeveral studies have shown that serum copper levels are related to coronary heart disease, diabetes, and cancer. However, the association of serum copper levels with all-cause, cause-specific [including cardiovascular disease (CVD) and cancer] mortality remains unclear.ObjectivesThis study aimed to prospectively examine the association of copper exposure with all-cause, CVD, and cancer mortality
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The mechanics of congenital heart disease: from a morphological trait to the functional echocardiographic evaluation Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-08 Martina Avesani, Jolanda Sabatino, Nunzia Borrelli, Irene Cattapan, Isabella Leo, Giulia Pelaia, Sara Moscatelli, Francesco Bianco, PierPaolo Bassareo, Francesco Martino, Benedetta Leonardi, Lilia Oreto, Paolo Guccione, Giovanni Di Salvo
Advances in pediatric cardiac surgery have resulted in a recent growing epidemic of children and young adults with congenital heart diseases (CHDs). In these patients, congenital defects themselves, surgical operations and remaining lesions may alter cardiac anatomy and impact the mechanical performance of both ventricles. Cardiac function significantly influences outcomes in CHDs, necessitating regular
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Research progress on the improvement of cardiovascular diseases through the autonomic nervous system regulation of the NLRP3 inflammasome pathway Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-08 Yuchi Hu, Songyuan Dai, Lulu Zhao, Ling Zhao
Cardiovascular disease stands as a leading global cause of mortality. Nucleotide-binding Oligomerization Domain-like Receptor Protein 3 (NLRP3) inflammasome is widely acknowledged as pivotal factor in specific cardiovascular disease progression, such as myocardial infarction, heart failure. Recent investigations underscore a close interconnection between autonomic nervous system (ANS) dysfunction and
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Single-cell RNA sequencing and ATAC sequencing identify novel biomarkers for bicuspid aortic valve-associated thoracic aortic aneurysm Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-08 Xu-Wen Liu, Pei Wang, Li Zhang, Yu Zhu, Jun-Yu Zhai, Chang-Nan Wang, Jun Li, Jian Xiao
IntroductionBicuspid aortic valve (BAV) is the most prevalent congenital cardiovascular defect and known to cause thoracic aortic aneurysms (TAAs). To improve our understanding of BAV pathogenesis, we characterized the cellular composition of BAV tissues and identified molecular changes in each cell population.MethodsTissue samples from two patients with BAV and two heart transplant donors were analyzed
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CHD-CXR: a de-identified publicly available dataset of chest x-ray for congenital heart disease Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-08 Li Zhixin, Luo Gang, Ji Zhixian, Wang Sibao, Pan Silin
Congenital heart disease is a prevalent birth defect, accounting for approximately one-third of major birth defects. The challenge lies in early detection, especially in underdeveloped medical regions where a shortage of specialized physicians often leads to oversight. While standardized chest x-rays can assist in diagnosis and treatment, their effectiveness is limited by subtle cardiac manifestations
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Predictors, clinical impact, and management strategies for conduction abnormalities after transcatheter aortic valve replacement: an updated review Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-08 Qingyun Yu, Qingan Fu, Yunlei Xia, Yanqing Wu
Transcatheter aortic valve replacement (TAVR) has increasingly become a safe, feasible, and widely accepted alternative surgical treatment for patients with severe symptomatic aortic stenosis. However, the incidence of conduction abnormalities associated with TAVR, including left bundle branch block (LBBB) and high-degree atrioventricular block (HAVB), remains high and is often correlated with risk
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Prediction of longitudinal clinical outcomes after acute myocardial infarction using a dynamic machine learning algorithm Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-05
Several regression-based models for predicting outcomes after acute myocardial infarction (AMI) have been developed. However, prediction models that encompass diverse patient-related factors over time are limited. This study aimed to develop a machine learning-based model to predict longitudinal outcomes after AMI. This study was based on a nationwide prospective registry of AMI in Korea (n = 13,104)
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The role of tubular cells in the pathogenesis of Fabry nephropathy Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-05
The pathophysiology of Fabry nephropathy (FN) is induced by galactosidase A deficiency with a chronic exposure of glycolipids to every lineage of renal cells. Tissue damage is attributed to the activation of molecular pathways, resulting in tissue fibrosis and chronic kidney disease. Podocytes have been the primary focus in clinical pathophysiological research because of the striking accumulation of
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A follow-up program in patients after hospitalization for heart failure: long-term health related quality of life and associated factors Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-05
BackgroundThe well-being of individuals with chronic heart failure (HF) is significantly influenced by their health-related quality of life (HRQoL), which serves as a crucial measure indicating how HF affects their daily activities. Monitoring programs aimed at reducing the number of hospitalizations and improving functional conditions are currently being offered to patients with chronic HF.The objectiveTo
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Effect of anticoagulation on the incidence of venous thromboembolism, major bleeding, and mortality among hospitalized COVID-19 patients: an updated meta-analysis Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-05
ObjectiveAnticoagulation is crucial for patients hospitalized with coronavirus disease 2019 (COVID-19) due to the high risk of venous thromboembolism (VTE). However, the optimal anticoagulation regimen needs further exploration. Therefore, we evaluated the efficacy and safety of diverse anticoagulation dosage dosages for COVID-19.MethodsAn updated meta-analysis was performed to assess the effect of
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Inhaled NO at a crossroads in cardiac surgery: current need to improve mechanistic understanding, clinical trial design and scientific evidence Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-05
Inhaled nitric oxide (NO) has been used in pediatric and adult perioperative cardiac intensive care for over three decades. NO is a cellular signaling molecule that induces smooth muscle relaxation in the mammalian vasculature. Inhaled NO has the unique ability to exert its vasodilatory effects in the pulmonary vasculature without any hypotensive side-effects in the systemic circulation. In patients
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Inhaled NO at a crossroads in cardiac surgery: current need to improve mechanistic understanding, clinical trial design and scientific evidence Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-05 Stefan Muenster, Iratxe Zarragoikoetxea, Andrea Moscatelli, Joan Balcells, Philippe Gaudard, Philippe Pouard, Nandor Marczin, Stefan P. Janssens
Inhaled nitric oxide (NO) has been used in pediatric and adult perioperative cardiac intensive care for over three decades. NO is a cellular signaling molecule that induces smooth muscle relaxation in the mammalian vasculature. Inhaled NO has the unique ability to exert its vasodilatory effects in the pulmonary vasculature without any hypotensive side-effects in the systemic circulation. In patients
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A follow-up program in patients after hospitalization for heart failure: long-term health related quality of life and associated factors Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-05 R. Paleckiene, D. Zaliaduonyte, V. Dambrauskiene, J. Macijauskiene
BackgroundThe well-being of individuals with chronic heart failure (HF) is significantly influenced by their health-related quality of life (HRQoL), which serves as a crucial measure indicating how HF affects their daily activities. Monitoring programs aimed at reducing the number of hospitalizations and improving functional conditions are currently being offered to patients with chronic HF.The objectiveTo
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The role of tubular cells in the pathogenesis of Fabry nephropathy Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-05 Paula Rozenfeld, Sandro Feriozzi, Fabian Braun
The pathophysiology of Fabry nephropathy (FN) is induced by galactosidase A deficiency with a chronic exposure of glycolipids to every lineage of renal cells. Tissue damage is attributed to the activation of molecular pathways, resulting in tissue fibrosis and chronic kidney disease. Podocytes have been the primary focus in clinical pathophysiological research because of the striking accumulation of
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Prediction of longitudinal clinical outcomes after acute myocardial infarction using a dynamic machine learning algorithm Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-05 Joo Hee Jeong, Kwang-Sig Lee, Seong-Mi Park, So Ree Kim, Mi-Na Kim, Shung Chull Chae, Seung-Ho Hur, In Whan Seong, Seok Kyu Oh, Tae Hoon Ahn, Myung Ho Jeong
Several regression-based models for predicting outcomes after acute myocardial infarction (AMI) have been developed. However, prediction models that encompass diverse patient-related factors over time are limited. This study aimed to develop a machine learning-based model to predict longitudinal outcomes after AMI. This study was based on a nationwide prospective registry of AMI in Korea (n = 13,104)
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Effect of anticoagulation on the incidence of venous thromboembolism, major bleeding, and mortality among hospitalized COVID-19 patients: an updated meta-analysis Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-05 Xinwang Chen, Suyun Zhang, Haiyu Liu, Qianyuan Zhang, Jinghan Chen, Qixian Zheng, Ningjing Guo, Yuanyuan Cai, Qiong Luo, Qian Xu, Sheng Yang, Xiangqi Chen
ObjectiveAnticoagulation is crucial for patients hospitalized with coronavirus disease 2019 (COVID-19) due to the high risk of venous thromboembolism (VTE). However, the optimal anticoagulation regimen needs further exploration. Therefore, we evaluated the efficacy and safety of diverse anticoagulation dosage dosages for COVID-19.MethodsAn updated meta-analysis was performed to assess the effect of
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Biomechanics-mediated endocytosis in atherosclerosis Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-04
Biomechanical forces, including vascular shear stress, cyclic stretching, and extracellular matrix stiffness, which influence mechanosensitive channels in the plasma membrane, determine cell function in atherosclerosis. Being highly associated with the formation of atherosclerotic plaques, endocytosis is the key point in molecule and macromolecule trafficking, which plays an important role in lipid
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Prevalence and outcomes of atrial fibrillation in patients suffering prostate cancer: a national analysis in the United States Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-04
PurposeAlthough the adverse effects of atrial fibrillation (AF) on cancers have been well reported, the relationship between the AF and the adverse outcomes in prostate cancer (PC) remains inconclusive. This study aimed to explore the prevalence of AF and evaluate the relationship between AF and clinical outcomes in PC patients.MethodsPatients diagnosed with PC between 2008 and 2017 were identified
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A novel approach for denoising electrocardiogram signals to detect cardiovascular diseases using an efficient hybrid scheme Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-04
BackgroundElectrocardiogram (ECG) signals are inevitably contaminated with various kinds of noises during acquisition and transmission. The presence of noises may produce the inappropriate information on cardiac health, thereby preventing specialists from making correct analysis.MethodsIn this paper, an efficient strategy is proposed to denoise ECG signals, which employs a time-frequency framework
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Characterization of myocardial injury phenotype by thermal liquid biopsy Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-04
Background and aimsWith the advent and implementation of high-sensitivity cardiac troponin assays, differentiation of patients with distinct types of myocardial injuries, including acute thrombotic myocardial infarction (TMI), acute non-thrombotic myocardial injury (nTMi), and chronic coronary atherosclerotic disease (cCAD), is of pressing clinical importance. Thermal liquid biopsy (TLB) emerges as
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Extending heart preservation to 24 h with normothermic perfusion Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-04
Cold static storage (CSS) for up to 6 h is the gold standard in heart preservation. Although some hearts stored over 6 h have been transplanted, longer CSS times have increased posttransplant morbimortality. Transmedics® Organ Care System (OCS™) is the only FDA-approved commercial system that provides an alternative to CSS using normothermic ex situ heart perfusion (NEHP) in resting mode with aortic
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Case Report: Abdominal surgery with the support of Impella (SURGELLA), a new frontier to be explored Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-04
A 74-year-old man with advanced heart failure was admitted to the hospital with a diagnosis of colorectal cancer, and he underwent surgery. To maintain stable hemodynamics, the Impella CP device was used. The patient was weaned from the device shortly after surgery, and he had an uneventful postoperative course. This case may pave the way for non-procrastinating surgery in patients with poorly stable
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Oral nitrate-reducing bacteria as potential probiotics for blood pressure homeostasis Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-04
Hypertension is a leading cause of morbidity and mortality worldwide and poses a major risk factor for cardiovascular diseases and chronic kidney disease. Research has shown that nitric oxide (NO) is a vasodilator that regulates vascular tension and the decrease of NO bioactivity is considered one of the potential pathogenesis of essential hypertension. The L-arginine-nitric oxide synthase (NOS) pathway
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Case Report: Abdominal surgery with the support of Impella (SURGELLA), a new frontier to be explored Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-04 Stefano Guarracini, Pierluigi Di Sebastiano, Fabio Francesco Di Mola, Raffaella Di Renzo, Lorenzo Mazzocchetti, Antonio M. Calafiore, Michele Di Mauro
A 74-year-old man with advanced heart failure was admitted to the hospital with a diagnosis of colorectal cancer, and he underwent surgery. To maintain stable hemodynamics, the Impella CP device was used. The patient was weaned from the device shortly after surgery, and he had an uneventful postoperative course. This case may pave the way for non-procrastinating surgery in patients with poorly stable
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Characterization of myocardial injury phenotype by thermal liquid biopsy Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-04 Karita C. F. Lidani, Robert Buscaglia, Patrick J. Trainor, Shubham Tomar, Alagammai Kaliappan, Andrew P. DeFilippis, Nichola C. Garbett
Background and aimsWith the advent and implementation of high-sensitivity cardiac troponin assays, differentiation of patients with distinct types of myocardial injuries, including acute thrombotic myocardial infarction (TMI), acute non-thrombotic myocardial injury (nTMi), and chronic coronary atherosclerotic disease (cCAD), is of pressing clinical importance. Thermal liquid biopsy (TLB) emerges as
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A novel approach for denoising electrocardiogram signals to detect cardiovascular diseases using an efficient hybrid scheme Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-04 Pinging Bing, Wei Liu, Zhixing Zhai, Jianghao Li, Zhiqun Guo, Yanrui Xiang, Binsheng He, Lemei Zhu
BackgroundElectrocardiogram (ECG) signals are inevitably contaminated with various kinds of noises during acquisition and transmission. The presence of noises may produce the inappropriate information on cardiac health, thereby preventing specialists from making correct analysis.MethodsIn this paper, an efficient strategy is proposed to denoise ECG signals, which employs a time-frequency framework
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Extending heart preservation to 24 h with normothermic perfusion Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-04 Brianna L. Spencer, Spencer K. Wilhelm, Christopher Stephan, Kristopher A. Urrea, Daniela Pelaez Palacio, Robert H. Bartlett, Daniel H. Drake, Alvaro Rojas-Pena
Cold static storage (CSS) for up to 6 h is the gold standard in heart preservation. Although some hearts stored over 6 h have been transplanted, longer CSS times have increased posttransplant morbimortality. Transmedics® Organ Care System (OCS™) is the only FDA-approved commercial system that provides an alternative to CSS using normothermic ex situ heart perfusion (NEHP) in resting mode with aortic
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Oral nitrate-reducing bacteria as potential probiotics for blood pressure homeostasis Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-04 Xiaofen Chai, Libing Liu, Feng Chen
Hypertension is a leading cause of morbidity and mortality worldwide and poses a major risk factor for cardiovascular diseases and chronic kidney disease. Research has shown that nitric oxide (NO) is a vasodilator that regulates vascular tension and the decrease of NO bioactivity is considered one of the potential pathogenesis of essential hypertension. The L-arginine-nitric oxide synthase (NOS) pathway
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Prevalence and outcomes of atrial fibrillation in patients suffering prostate cancer: a national analysis in the United States Front. Cardiovasc. Med. (IF 3.6) Pub Date : 2024-04-04 Zhemin Pan, Xiao Xu, Xi Xu, Shengyong Wu, Zhensheng Zhang, Suxuan Liu, Zhijian Liu, Boxiang Tu, Chenxin Chen, Yingyi Qin, Jia He
PurposeAlthough the adverse effects of atrial fibrillation (AF) on cancers have been well reported, the relationship between the AF and the adverse outcomes in prostate cancer (PC) remains inconclusive. This study aimed to explore the prevalence of AF and evaluate the relationship between AF and clinical outcomes in PC patients.MethodsPatients diagnosed with PC between 2008 and 2017 were identified