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Association between extrapolated time in range and large for gestational age infants in pregnant women with type 1 diabetes J. Diabetes its Complicat. (IF 3.0) Pub Date : 2024-03-19 Enio A.M. Santos, Tatiana A. Zaccara, Cristiane F. Paganoti, Stela V. Peres, Rossana P.V. Francisco, Rafaela A. Costa
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Analysis of the therapeutic potential of miR-124 and miR-16 in non-alcoholic fatty liver disease J. Diabetes its Complicat. (IF 3.0) Pub Date : 2024-03-12 Ali Mahmoudi, Amin Jalili, Seyed Hamid Aghaee-Bakhtiari, Reza Kazemi Oskuee, Alexandra E. Butler, Manfredi Rizzo, Amirhossein Sahebkar
Non-alcoholic fatty liver disease (NAFLD) is a common condition affecting >25 % of the population worldwide. This disorder ranges in severity from simple steatosis (fat accumulation) to severe steatohepatitis (inflammation), fibrosis and, at its end-stage, liver cancer. A number of studies have identified overexpression of several key genes that are critical in the initiation and progression of NAFLD
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Association between obstructive coronary disease and diabetic retinopathy: Cross-sectional study of coronary angiotomography and multimodal retinal imaging J. Diabetes its Complicat. (IF 3.0) Pub Date : 2024-03-06 Andre Chateaubriand Campos, Eduardo Gomes Lima, Peter Karl Jacobsen, Louis Arnould, Simao Lottenberg, Renata Martins Maia, Livia Silva Conci, Tomas Minelli, Andrea Morato, Roberto Nery Dantas-Jr, Cesar Higa Nomura, Pedro Rissoli, Sergio Gianotti Pimentel, Carlos Vicente Serrano Junior
To investigate the association between diabetic retinopathy (DR) and coronary artery disease (CAD) using coronary angiotomography (CCTA) and multimodal retinal imaging (MMRI) with ultra-widefield retinography and optical coherence tomography angiography and structural domain. Single-center, cross-sectional, single-blind. Patients with diabetes who had undergone CCTA underwent MMRI. Uni and multivariate
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Effect of denosumab on inflammation and bone health in active Charcot foot: A phase II randomised controlled trial J. Diabetes its Complicat. (IF 3.0) Pub Date : 2024-03-05 Joel Willem Johan Lasschuit, Jacqueline Ruth Center, Jerry Richard Greenfield, Katherine Thuy Trang Tonks, Charcot Foot Quantitative Ultrasound and Denosumab Study (CRUSADES) Investigators
We aimed to investigate the effect of denosumab on pedal bone health and clinical resolution in active Charcot foot (CN). This multicentre open-label phase 2 randomised controlled trial recruited adults with diabetes mellitus and active CN within 3 months of onset. Participants were randomised to standard care alone, or with denosumab 60 mg subcutaneously. Denosumab was administered at baseline and
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Gestational diabetes and risk of future diabetes in a multi-ethnic population J. Diabetes its Complicat. (IF 3.0) Pub Date : 2024-03-04 Noa Tsur, Meir Frankel, Avivit Cahn, Anat Tsur
To investigate ethnic disparities in risk of gestational diabetes-mellitus (GDM) and future diabetes. A population-based retrospective cohort study of women who underwent a 100-g oral glucose-tolerance-test (oGTT) during pregnancy between 2007 and 2017 in Clalit-Health-Services of the Jerusalem district. Univariate and multivariate logistic regression analyses were used to compare the risk of GDM in
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Multidisciplinary management of diabetic foot infection associated with improved 8-year overall survival J. Diabetes its Complicat. (IF 3.0) Pub Date : 2024-03-03 Miska Vuorlaakso, Verna Karèn, Juha Kiiski, Jorma Lahtela, Ilkka Kaartinen
Diabetic foot syndrome is a global challenge best managed through multidisciplinary collaboration. This study aimed to investigate the effect of a systematic multidisciplinary team (MDT) on the overall survival and major amputation-free survival of hospitalized patients with diabetic foot infection (DFI). This retrospective cohort study was conducted at Tampere University Hospital. Cohorts of hospitalized
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Increased skeletal muscle mass index was involved in glycemic efficacy following diabetes treatment, and changes in fat mass index correlated with the changes in the lipid ratio in type 2 diabetes J. Diabetes its Complicat. (IF 3.0) Pub Date : 2024-02-27 Shun Matsuura, Soichiro Nagata, Koji Shibazaki, Reiko Uchida, Yukiko Imai, Shoko Shibata, Hiroshi Morita
This study aimed to investigate the association between changes in body composition, glycated hemoglobin, and lipid ratio during the treatment of patients with type 2 diabetes mellitus (T2DM). This retrospective analysis used data from outpatients with T2DM who had confirmed body composition and measured laboratories at administration and after treatment. The baseline characteristics and prescribed
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Relationship between adiponectin and muscle mass in patients with metabolic syndrome and obesity J. Diabetes its Complicat. (IF 3.0) Pub Date : 2024-02-21 Daniel de Luis, David Primo, Olatz Izaola, Juan José Lopez Gomez
Adiponectin is one of the most important adipokines in human beings. Obesity and sarcopenia are associated with a low-level chronic inflammatory status, and adiponectin plays an anti-inflammatory role. The objective of the current work was to study the association between muscle mass, determined via bioelectrical impedance (BIA), and circulating adiponectin levels among obese patients with metabolic
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Outcomes associated with a variable rate insulin infusion diabetic ketoacidosis protocol J. Diabetes its Complicat. (IF 3.0) Pub Date : 2024-02-15 Anojian Koneshamoorthy, Dilan Seneviratne Epa, David N. O'Neal, Melissa H. Lee, John D. Santamaria, Richard J. MacIsaac
To relate adverse events with glucose correction rates in diabetic ketoacidosis (DKA) using variable rate intravenous insulin-infusions (VRIII). Retrospective, observational study in adults with DKA who received insulin infusions between 2012 and 2017 at St Vincent's Hospital, Melbourne. Early correction of hyperglycaemia (<10 mmol/L) was evaluated for association with hypoglycaemia (<4.0 mmol/L),
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Early glucose abnormalities revealed by continuous glucose monitoring associate with lung function decline in cystic fibrosis: A five-year prospective study J. Diabetes its Complicat. (IF 3.0) Pub Date : 2024-02-14 Luc Rakotoarisoa, Laurence Weiss, François Lefebvre, Michele Porzio, Benjamin Renaud-Picard, Bruno Ravoninjatovo, Michel Abely, Isabelle Danner-Boucher, Séverine Dubois, Françoise Troussier, Anne Prevotat, Gilles Rault, Romain Kessler, Laurence Kessler
Cystic fibrosis related diabetes (CFRD) is commonly associated with declining lung function and nutritional status. We aimed to evaluate the pulmonary impact of early glucose abnormalities by using 2-h standard oral glucose tolerance testing (OGTT) and continuous glucose monitoring (CGM) in people with cystic fibrosis (PwCF). PwCF aged ≥10 years old without known CFRD were included in a five-year prospective
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The incidence of retinopathy in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness study (GRADE) J. Diabetes its Complicat. (IF 3.0) Pub Date : 2024-02-05 Daniel S. Hsia, Naji Younes, Heidi Krause-Steinrauf, Laure Sayyed Kassem
Based on self-report in the GRADE diabetes study, cumulative incidence of retinopathy was low over 5 years (3.7 %; 184 of 4098 participants) and did not differ among the 4 treatment groups (glargine 4.0 %, glimepiride 3.2 %, liraglutide 3.7 %, sitagliptin 3.8 %). There were no differences in retinopathy with specific therapies in GRADE.
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Disease-modifying therapies for diabetic peripheral neuropathy: A systematic review and meta-analysis of randomized controlled trials J. Diabetes its Complicat. (IF 3.0) Pub Date : 2024-02-01 Gui-Lin Ran, Yan-Ping Li, Li-Chin Lu, Shao-Huan Lan
Alpha-lipoic acid, epalrestat, and mecobalamin are widely used as monotherapies for diabetic peripheral neuropathy. However, whether a triple-combination therapy with these three drugs is superior to monotherapy or dual therapy remains debatable. Nine randomized controlled trials were identified through a search on electronic databases such as PubMed, Web of Science, and Cochrane Library. The trial
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Delayed prandial insulin boluses are an important determinant of blood glucose control and relate to fear of hypoglycemia in people with type 1 diabetes on advanced technologies J. Diabetes its Complicat. (IF 3.0) Pub Date : 2024-01-17 Giovanni Annuzzi, Raffaella Triggiani, Raffaele De Angelis, Carmen Rainone, Alessandra Corrado, Giuseppe Scidà, Roberta Lupoli, Lutgarda Bozzetto
Aims Automated insulin delivery systems improve blood glucose control in patients with type 1 diabetes (T1D). However, optimizing their performance requires patient's proper compliance to meal insulin bolus administration. We explored real-life prevalence of delayed prandial boluses (DBs) in adults with T1D on advanced technologies, and their association with glycemic control and fear of hypoglycemia
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Autologous platelet-rich plasma (APRP) in diabetes foot disease: a meta-analysis J. Diabetes its Complicat. (IF 3.0) Pub Date : 2024-01-19 Maria Ruiz-Muñoz, Francisco-Javier Martinez-Barrios, Raul Fernandez-Torres, Eva Lopezosa-Reca, Ana Marchena-Rodriguez
Introduction This study will explore the effectiveness of autologous platelet-rich plasma in the treatment of diabetic foot disease compared to conventional treatments, based on the ulcer healing rate. Methods The electronic databases of PubMed, EMBASE, and WOS internet were searched. Evaluated outcome rate of complete ulcer healing. Statistical analysis was performed with RevMan 5.0 software and SPSS
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Dapagliflozin attenuates renal fibrosis by suppressing angiotensin II/TGFβ signaling in diabetic mice J. Diabetes its Complicat. (IF 3.0) Pub Date : 2024-01-16 Mingwang Jiang, Zhichen Yang, Lu Lyu, Meng Shi
Aims Diabetic nephropathy (DN) complicates diabetes Mellitus and intimately relates to intrarenal renin–angiotensin system (RAS) activity. Dapagliflozin, a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2), has been validated to improve renal outcomes in diabetic patients from clinical research by elusive mechanisms. This study explored the presumption that the eagerness activity of intrarenal
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Novel gene-based therapeutic approaches for the management of hepatic complications in diabetes: Reviewing recent advances J. Diabetes its Complicat. (IF 3.0) Pub Date : 2024-01-11 Qingzhu Yan, Dongfu Li, Shengnan Jia, Junling Yang, Jingru Ma
Diabetes mellitus is a chronic metabolic disorder marked by hyperglycemia and systemic complications, including hepatic dysfunction, significantly contributing to disease progression and morbidity. This article reviews recent advances in gene-based therapeutic strategies targeting hepatic complications in diabetes, offering a promising approach for precision medicine by addressing underlying molecular
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Reduced skeletal muscle mass to visceral fat area ratio is independently associated with reduced cognitive function in type 2 diabetes mellitus J. Diabetes its Complicat. (IF 3.0) Pub Date : 2024-01-03 Serena Low, Tze Pin Ng, Kiat Sern Goh, Angela Moh, Jonathon Khoo, Keven Ang, Philip Yap, Chin Yee Cheong, Wern Ee Tang, Ziliang Lim, Tavintharan Subramaniam, Chee Fang Sum, Su Chi Lim
Aim Skeletal muscle mass to visceral fat area ratio (SVR) has been recognised as an index of sarcopenic obesity. SVR is associated with type 2 diabetes mellitus (T2DM), metabolic syndrome and arterial stiffness which are known risk factors for cognitive dysfunction. We aimed to investigate association between SVR and cognitive function in patients with T2DM. Methods This was a cross-sectional study
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Corrigendum to “Cumulative incidence of and risk factors for herpes zoster among patients with diabetes mellitus: Results from a 10-year nested case-control study” [J Diabetes Complicat., Volume 36, Issue 5, May 2022, 108168] J. Diabetes its Complicat. (IF 3.0) Pub Date : 2024-01-05 Nalinee Chuanchaiyakul, Nuntakorn Thongtang, Pinyo Rattanaumpawan
Abstract not available
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The effects of semaglutide, empagliflozin and their combination on the kidney sodium signal from magnetic resonance imaging: A prespecified, secondary analysis from a randomized, clinical trial J. Diabetes its Complicat. (IF 3.0) Pub Date : 2024-01-05 Søren Gullaksen, Liv Vernstrøm, Steffen S. Sørensen, Steffen Ringgaard, Christoffer Laustsen, Henrik Birn, Kristian L. Funck, Per L. Poulsen, Esben Laugesen
Aims To evaluate the effect of treatment with semaglutide and empagliflozin on the cortico-medullary sodium gradient (MCR; medulla/cortex ratio), urine sodium/creatinine ratio (UNACR), and estimated plasma volume (ePV) and to compare the MCR between persons with and without type 2 diabetes. Methods Using the 23Na magnetic resonance imaging (23Na-MRI) technique, we investigated the effects of 32 weeks
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Prevalence and predictors of erectile dysfunction among men in the diabetes prevention program outcomes study J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-12-29 Yooni A. Blair, Lindsay Doherty, Marinella Temprosa, Rodica Pop-Busui, Kishore M. Gadde, Prachi Singh, Arthur H. Owora, Hunter Wessells, Aruna V. Sarma
Objective To determine burden and identify correlates of erectile dysfunction (ED) among men with prediabetes (PreD) and type 2 diabetes (T2D) enrolled in the Diabetes Prevention Program (DPP) Outcomes Study (DPPOS). Research design and methods The 2017 DPPOS visit included administration of the International Index of Erectile Function. Of 648 male participants, 88 % (n = 568) completed the survey
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Systemic and ocular outcomes in patients with young-onset type 2 diabetes J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-12-22 Adrian Au, Bryce T. Bajar, Brittany M. Wong, Lauren P. Daskivich, Hamid Hosseini, Pradeep S. Prasad
Purpose To analyze the systemic and ocular outcomes in patients with young-onset type 2 diabetes (YO-DM2) based on grade of presenting diabetic retinopathy (DR). Methods Retrospective cohort study analysis of empaneled patients with type 2 diabetes <40 years old with retinopathy screening within the Los Angeles Department of Health Services between 01/01/2017–07/01/2021 were included. Patients were
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The handgrip test – A historical test for diabetic autonomic neuropathy or a marker of something else? J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-12-21 Anna Erzsébet Körei, Zsuzsanna Putz, Orsolya Erzsébet Vági, Dóra Zsuzsanna Tordai, Adrienn Menyhárt, Ildikó Istenes, Viktor József Horváth, Péter Kempler
Cardiovascular autonomic neuropathy (CAN) is a frequent complication of diabetes mellitus and is associated with increased morbidity and mortality in patients with diabetes. Hence, early and correct diagnosis of CAN is crucial. Standard cardiovascular reflex rests (CARTs) have been the gold standard of CAN assessment. Originally, CARTs consisted of five reflex tests, but measuring diastolic blood pressure
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Roles and mechanisms of umbilical cord mesenchymal stem cells in the treatment of diabetic foot: A review of preclinical and clinical studies J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-12-21 Haorui Zhang, Yuanrui Gu, Ke Zhang, Yanxia Tu, Chenxi Ouyang
Aims Growing preclinical and clinical evidence has suggested the potential method of umbilical cord mesenchymal stem cell (UCMSC) therapy for diabetic foot. Thus, the authors provided an outline of the application of UCMSCs in the treatment of diabetic foot and further summarized the roles and mechanisms of this therapy. Data synthesis With no time limitations, the authors searched the Web of Science
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Diabetic ketosis vs ketoacidosis as initial presentation of pediatric type 1 diabetes mellitus. Associated features and rate of progression during the first two years after diagnosis J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-12-21 Aristeidis Giannakopoulos, Natasa Chrysanthakopoulou, Alexandra Efthymiadou, Dionisios Chrysis
Aims In this study we described the clinical and laboratory features of children presented with diabetic ketosis or diabetic ketoacidosis at diagnosis of type 1 diabetes (T1DM) and evaluated its course up to 2 years after initial diagnosis to investigate the progression rate of T1DM in both groups. Methods This was a prospective longitudinal cohort study that included 59 children and adolescents presented
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Program ACTIVE II: 6- and 12-month outcomes of a treatment approach for major depressive disorder in adults with type 2 diabetes J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-12-21 Chandan K. Saha, Jay H. Shubrook, W. Guyton Hornsby, Ziyi Yang, Yegan Pillay, Kieren J. Mather, Mary de Groot
Aims To evaluate the long-term effects of behavioral treatments on glycemic and psychological outcomes for patients with major depressive disorder (MDD) and type 2 diabetes (T2D). Methods Program ACTIVE II was a multicenter randomized controlled comparative effectiveness trial of cognitive behavioral therapy (CBT), exercise (EXER), combination treatment (CBT + EXER) and usual care (UC) for adults with
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Lower extremity arterial plaque in patients with type 2 diabetes mellitus: A cross-sectional study of 25-(OH)D3 and other risk factors J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-12-14 Xuechun Hang, Xiaohua Yu, Shengyu Fan
Objective The occurrence of chronic vascular complications in individuals with type 2 diabetes mellitus(T2DM) is influenced by multiple factors. This study aims to analyze the correlation between serum 25-(OH)D3 levels and other risk factors with the formation and severity of arterial plaques in the lower extremities, and explore its role in clinical diagnosis and treatment. Methods A total of 628
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Soluble urokinase plasminogen activator receptor, platelet aggregation, and carotid plaque thickness in diabetes: A cross-sectional analysis J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-11-29 Viktor Rotbain Curovic, Juliette Tavenier, Luis F. Ferreira-Divino, Christina G. Poulsen, Morten B. Houlind, Oliver B. Pedersen, Lærke Urbak, Tine W. Hansen, Henrik Sillesen, Marie Frimodt-Møller, Anne-Mette Hvas, Peter Rossing
Background Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory biomarker strongly linked with cardiovascular disease in diabetes. By investigating its association with platelet aggregation levels and carotid plaque thickness, we can potentially improve the characterization of cardiovascular pathophysiology in type 1 (T1D) and type 2 diabetes (T2D). Methods SuPAR was measured
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Von Willebrand factor hyperactivity affects the outcome of lower limb revascularization in subjects with type 2 diabetes mellitus complicated by diabetic foot vasculopathy: An observational pilot study J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-11-25 Pitocco Dario, Popolla Valentina, Rizzi Alessandro, Lancellotti Stefano, Tartaglione Linda, Sacco Monica, Viti Luca, Mazzotta Francesco Antonio, Iezzi Roberto, Santoliquido Angelo, Caputo Salvatore, Flex Andrea, Pontecorvi Alfredo, De Cristofaro Raimondo
Aim of this study is to evaluate any differences in VWF antigen, VWF activity and ADAMTS-13 activity before and after successful and non-successful Percutaneous Transluminal Angioplasty (PTA) in subjects with type 2 diabetes (T2DM) complicated by Chronic limb-threatening ischemia (CLTI) in diabetic foot vasculopathy. Methods In this prospective observational pilot study, we enrolled 35 T2DM subjects
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“It changed everything we do”: A mixed methods study of youth and parent experiences with a pilot exercise education intervention following new diagnosis of type 1 diabetes J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-11-24 Molly L. Tanenbaum, Ananta Addala, Sarah Hanes, Victor Ritter, Franziska K. Bishop, Ana L. Cortes, Erica Pang, Korey K. Hood, David M. Maahs, Dessi P. Zaharieva
Aims This pilot study delivered a comprehensive exercise education intervention to youth with new-onset type 1 diabetes (T1D) and their parents to increase knowledge and confidence with physical activity (PA) shortly after diagnosis. Methods Youth initiated continuous glucose monitoring (CGM) and PA trackers within 1 month of diagnosis. Youth and their parents received the 4-session intervention over
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Beyond pounds: What else could be lost? J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-11-19 Thaer Idrees, Guillermo E. Umpierrez
Abstract not available
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Inhibition of IL-33 signaling ameliorate hepatic fibrosis with decreasing MCP-1 in a mouse model of diabetes and non-alcoholic steatohepatitis; comparison for luseogliflozin, an SGLT2 inhibitor J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-11-23 Sho Wakamatsu, Teruo Jojima, Masaaki Hashiguchi, Haruka Kishi, Takafumi Niitani, Shintaro Sakurai, Toshie Iijima, Takahiko Kogai, Takuya Tomaru, Isao Usui, Yoshimasa Aso
Non-alcoholic fatty liver disease (NAFLD) is increasing globally, and seeking therapeutic molecule targets is urgent. Several studies have demonstrated that IL-33 plays an important role in the progression of Non-alcoholic steatohepatitis (NASH) with fibrosis and the proliferation of hepatocellular carcinoma (HCC). However, whether the inhibition of IL-33 signaling prevents NAFLD from progressing to
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SGLT2 inhibitor improves kidney function and morphology by regulating renal metabolism in mice with diabetic kidney disease J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-11-21 Chunru Yang, Cheng Xiao, Xiaojun Zhai, Jieying Liu, Miao Yu
Background Diabetic kidney disease (DKD) is a secondary complication of diabetes mellitus and a leading cause of chronic kidney disease. Aim To investigate the impact of long-term canagliflozin treatment on DKD and elucidate its underlying mechanism. Methods DKD model was established using high-fat diet and streptozotocin in male C57BL/6J mice (n = 30). Mice were divided into five groups and treated
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Fasting and postprandial plasma glucose contributions to hemoglobin A1c and time in range in people with diabetes on multiple daily injection insulin therapy: Results from the PRONTO-T1D and PRONTO-T2D clinical trials J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-11-16 Carolina Piras de Oliveira, Mary Anne Dellva, Juliana Bue-Valleskey, Annette M. Chang, Birong Liao
Aims To investigate contributions of changes in fasting plasma glucose (FPG) and postprandial glucose (PPG) to changes in hemoglobin A1c (HbA1c) and time-in-range (TIR, 70–180 mg/dL) in people with type 1 diabetes (T1D) and type 2 diabetes (T2D) treated with multiple daily injections (MDI) of insulin lispro (rapid/ultra-rapid formulations). Methods Multivariate regression models were used to quantify
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GLP-1 and dual GIP/GLP-1 receptor agonists in overweight/obese patients for atherosclerotic cardiovascular disease prevention: Where are we now? J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-11-07 Emir Muzurović, Volkan Demirhan Yumuk, Manfredi Rizzo
Abstract not available
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Comparative evaluation of LDL-CT, non-HDL/HDL ratio, and ApoB/ApoA1 in assessing CHD risk among patients with type 2 diabetes mellitus J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-10-27 Ioana Păunică, Andrada Doina Mihai, Simona Ștefan, Anca Pantea- Stoian, Cristian Serafinceanu
Background Research proved the importance of dosing apolipoprotein B (ApoB) over LDL cholesterol as a predictor of cardiovascular events. In this study, we aimed to observe the input apolipoprotein A1 (ApoA1) and ApoB, primarily if its ratio could provide in patients with type 2 diabetes mellitus (T2DM) without known atherosclerotic events regarding the coronary heart disease (CHD) risk. Methods We
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24-h ambulatory blood pressure readings and associations with albuminuria in youth with type 2 diabetes: A cross sectional analysis from the iCARE cohort J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-10-30 Allison B. Dart, Elizabeth A.C. Sellers, Jonathan McGavock, Melissa Del Vecchio, Brenden Dufault, Jill Hamilton, M. Constantine Samaan, Josephine Ho, Sydnee Monias, Brandy Wicklow
Aims To evaluate associations between 24-h ambulatory blood pressure monitor (ABPM) data vs. single casual blood pressure (BP) and albuminuria in youth with type 2 diabetes. Methods A cross-sectional analysis of youth with type 2 diabetes 10–<18 yrs. from the iCARE cohort. Main exposures: daytime HTN (+/− nocturnal), isolated nocturnal HTN and single casual BP. Main outcome: non-orthostatic urine albumin:
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Systemic biomarkers of microvascular alterations in type 1 diabetes associated neuropathy and nephropathy - A prospective long-term follow-up study J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-10-26 Evangelia Baldimtsi, Per A. Whiss, Jeanette Wahlberg
Introduction This study aimed to investigate circulating biomarkers associated with the risk of developing diabetic peripheral neuropathy (DPN) and nephropathy in type 1 diabetes (T1D). Materials and methods Patients with childhood-onset T1D (n = 49, age 38.3 ± 3.8 yrs.) followed prospectively were evaluated after 30 years of diabetes duration. DPN was defined as an abnormality in nerve conduction
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Understanding the mechanisms mediating cardi-renal benefit of empagliflozin in type 2 diabetes mellitus J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-10-23 Dimitrios Patoulias, Ali H. Eid, Manfredi Rizzo
Abstract not available
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Insights from insulin resistance pathways: Therapeutic approaches against Alzheimer associated diabetes mellitus J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-10-18 Ayesha Fauzi, Ewen Se Thoe, Tang Yin Quan, Adeline Chia Yoke Yin
Alzheimer Associated Diabetes Mellitus, commonly known as Type 3 Diabetes Mellitus (T3DM) is a distinct subtype of diabetes with a pronounced association with Alzheimer's disease (AD). Insulin resistance serves as a pivotal link between these two conditions, leading to diminished insulin sensitivity, hyperglycemia, and impaired glucose uptake. The brain, a vital organ in AD context, is also significantly
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The effect of sodium-glucose cotransporter 2 inhibitors as an adjunct to insulin in patients with type 1 diabetes assessed by continuous glucose monitoring: A systematic review and meta-analysis J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-10-21 Mengnan Li, Zi'ang Liu, Xifeng Yang, Jiaxin Zhang, Minmin Han, Yi Zhang, Yunfeng Liu
Aims Patients undergoing insulin-based therapy for type 1 diabetes often experience poor glycemic control characterized by significant fluctuations. This study was undertaken to analyze the effect of sodium-glucose cotransporter 2 inhibitors (SGLT2Is), as an adjunct to insulin, on time in range (TIR) and glycemic variability in patients with type 1 diabetes, using continuous glucose monitoring (CGM)
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Dapagliflozin ameliorated retinal vascular permeability in diabetic retinopathy rats by suppressing inflammatory factors J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-10-17 Chengye Xu, Hongxue Li, Qian Xu, Kangqi Zhao, Ming Hao, Wenjian Lin, Xuefei Ma, Xinyuan Gao, Hongyu Kuang
Background Diabetic retinopathy is a common microvascular complication of diabetes and one of the major causes of blindness in the working-age population. Emerging evidence has elucidated that inflammation drives the key mechanism of diabetes-mediated retinal disturbance. As a new therapeutic drug targeting diabetes, whether dapagliflozin could improve vascular permeability from the perspective of
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Shifts in KDIGO CKD risk groups with empagliflozin: Kidney-protection from SGLT2 inhibition across the spectrum of risk J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-10-10 Robert Weingold, Bernard Zinman, Michaela Mattheus, Anne Pernille Ofstad, Dominik Steubl, Christoph Wanner, Silvio E. Inzucchi
T2D is a well-established risk factor for development and progression of CKD. KDIGO recommends categorization of risk by likelihood of progression to ESKD. Compared to placebo, empagliflozin decreases likelihood of worsening (OR 0.70, 95 % CI 0.62–0.78) and increases likelihood of improvement (OR 1.56, 95 % CI 1.30–1.86) in KDIGO risk category.
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Utilization and impact of SLGT2 inhibitors among diabetes patients in a nationally representative survey: Findings from NHANES 2013–2020 J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-10-03 Tsung-Hua Shen, Joel F. Farley
Background and aims The purpose of this study is to examine patterns of utilization for antidiabetic medications among a nationally representative sample of the US population following the introduction of SGLT2 inhibitors in 2013. Methods The study utilized National Health and Nutrition Examination Survey (NHANES) data from 2013 to 2020 to identify adult patients with diabetes using antidiabetic medication
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Effects of advanced glycation end-products, diabetes and metformin on the osteoblastic transdifferentiation capacity of vascular smooth muscle cells: In vivo and in vitro studies J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-10-04 María Silvina Molinuevo, Ana María Cortizo, Claudia Sedlinsky
Aims Our objective was to study the vascular smooth muscle cells (VSMC) osteoblastic transdifferentiation in AGE exposed cells or those from diabetic animals, and its response to metformin treatment. Methods VSMC were obtained from non-diabetic rats, grown with or without AGE; while VSMC of in vivo-ex vivo studies were obtained from non-diabetic control animals (C), diabetic (D), C treated with metformin
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Targeting of insulin receptor endocytosis as a treatment to insulin resistance J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-09-27 Bryce Tim, Valentina L. Kouznetsova, Santosh Kesari, Igor F. Tsigelny
Background Insulin resistance is the decreased effectiveness of insulin receptor function during signaling of glucose uptake. Insulin receptors are regulated by endocytosis, a process that removes receptors from the cell surface to be marked for degradation or for re-use. Objectives Our goal was to discover insulin-resistance-related genes that play key roles in endocytosis which could serve as potential
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Asprosin, a novel glucogenic adipokine implicated in type 2 diabetes mellitus J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-09-25 Hongcui Diao, Xue Li, Yeqiu Xu, Xiuli Xing, Shuguang Pang
Asprosin, encoded by penultimate two exons (exon 65 and exon 66) of the gene Fibrillin 1 (FBN1), has been recently discovered to be a novel hormone secreted by white adipose tissues during fasting. The glucose metabolism disorders are often accompanied by increased asprosin level. Previous research suggests that asprosin may contribute to the development of diabetes by regulating glucose homeostasis
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Usefulness of glucose management indicator derived from continuous glucose monitoring to assess glycemic condition in hospitalized patients with diabetic kidney disease treated with insulin pumps J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-09-18 Yi Lu, Qian Zhang, Xiangyu Wang, Ya Jiang, Yaoming Xue
Background and objective This study described the relationship of HbA1c and continuous glucose monitoring (CGM) derived glucose management indicator (CGM-derived GMI) and developed a model to estimate GMI based on clinical parameters (clinical-parameter GMI) for hospitalized DKD treated with insulin pump. Methods This observational study collected clinical data of hospitalized DKD treated with insulin
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Corrigendum to “The PanGut-study: Evoked potentials following rectal balloon distention, a way of evaluating diabetic autonomic neuropathy in the gut?” [J. Diabetes Complicat., Volume 37, Issue 5, May 2023, 108452] J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-09-09 Sondre Meling, Erling Tjora, Heike Eichele, Rasmus Bach Nedergaard, Niels Ejskjaer, Christina Brock, Eirik Søfteland
Abstract not available
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Dipeptidyl peptidase-4 inhibitor-related renal disease J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-09-01 Atsuhiko Suenaga, Naoki Sawa, Yuki Oba, Daisuke Ikuma, Akinari Sekine, Eiko Hasegawa, Hiroki Mizuno, Tatsuya Suwabe, Sara Ikeda, Tetsuro Tsujimoto, Kei Kono, Yukako Shintani-Domoto, Keiichi Kinowaki, Kenichi Ohashi, Motoaki Miyazono, Yutaka Yamaguchi, Yoshifumi Ubara
Background Dipeptidyl peptidase-4 (DPP-4) inhibitors are widely used to treat type 2 diabetes (T2D). Lowering blood glucose is expected also to reduce the progression of diabetic nephropathy. We experienced a patient with T2D who achieved good glycemic control with a DPP-4 inhibitor but experienced rapid deterioration of renal function. Therefore, we performed a retrospective study of similar patients
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Vitamin D deficiency and development of complications in individuals with type 1 and type 2 diabetes: A cohort study J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-09-06 Ninna Hahn Tougaard, Tine Willum Hansen, Peter Rossing
Aims To investigate vitamin D deficiency as a risk marker for complications in individuals with type 1 and type 2 diabetes. Methods A cohort study including 1448 adults with type 1 and 770 with type 2 diabetes. Individuals in the decile with lowest vitamin D level were classified as vitamin D deficient. Outcomes based on medical records and registers included mortality, major adverse cardiovascular
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Association of insomnia with incident chronic cognitive impairment in older adults with type 2 diabetes mellitus: A prospective study of the Hong Kong Diabetes Register J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-09-04 Chun-Kwan O, Brian Wai-Hei Siu, Vanessa Wai-Shan Leung, Yuan-yuan Lin, Chen-zhao Ding, Eric Siu-Him Lau, Jamie Cheung, Andrea On-Yan Luk, Elaine Yee-Kwan Chow, Ronald Ching-Wan Ma, Juliana Chung-Ngor Chan, Rachel Ngan-Yin Chan, Yun Kwok Wing, Alice Pik-Shan Kong
Aims To examine the risk association of insomnia with incident chronic cognitive impairment in older adults with type 2 diabetes mellitus (T2D). Methods Between July 2010 and June 2015, patients with T2D aged ≥60 years enrolled in the Hong Kong Diabetes Register completed the Insomnia Severity Index (ISI) questionnaire. Patients were considered having insomnia if they had ISI score > 14. We prospectively
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Effect of dapagliflozin on liver and pancreatic fat in patients with type 2 diabetes and non-alcoholic fatty liver disease J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-09-01 Mengran Shi, Hao Zhang, Wei Wang, Xiao Zhang, Jiawei Liu, Qixian Wang, Yuan Wang, Chunlin Zhang, Xiaoqin Guo, Qiao Qiao, Chun Cui, Jing Xu, Jian Wang
Aims To evaluate the effect of dapagliflozin on liver fat content (LFC) and pancreatic fat content (PFC). Materials and methods 84 patients with type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD) were randomly assigned to receive either dapagliflozin (n = 42) or serve as controls (n = 42). The primary endpoint is changes in LFC and PFC using magnetic resonance imaging estimated proton
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Protective effect of evolocumab on Müller cells in the rat retina under hyperglycaemic and hypoxic conditions J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-08-30 Qing Zhou, Huan Tang, Shuting Li
Aims In this study, rat retinal Müller cells (RMCs) were cultured in vitro to investigate the protective mechanism of evolocumab on rat RMCs in diabetes mellitus (DM) and the expression of relevant inflammatory factors. Methods The expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) in the retinal tissues of diabetic rats was detected by immunohistochemistry. Sprague-Dawley (SD) rats
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Design and rationale of the myocardial infarction and new treatment with metformin study (MIMET) - Study protocol for a registry-based randomised clinical trial J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-08-30 Viveca Ritsinger, Emil Hagström, Kristina Hambraeus, Stefan James, Tomas Jernberg, Bo Lagerqvist, Margrét Leosdottir, Pia Lundman, John Pernow, Ollie Östlund, Anna Norhammar
Aims To investigate if addition of metformin to standard care (life-style advice) reduces the occurrence of cardiovascular events and death after myocardial infarction (MI) in patients with newly detected prediabetes. Methods The Myocardial Infarction and new treatment with Metformin study (MIMET) is a large multicentre registry-based randomised clinical trial (R-RCT) within the SWEDEHEART registry
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Elevated risk of developing type 2 diabetes in people with a psychiatric disorder: What is the role of health behaviors and psychotropic medication? J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-08-26 Nanna Lindekilde, Lars J. Diaz, Mathias Lasgaard, Jan Erik Henriksen, Stine H. Scheuer, Gregers S. Andersen, Katrine H. Rubin, Frans Pouwer
Aims Several psychiatric disorders are linked with an increased risk of developing type 2 diabetes (T2D), but the mediating mechanisms are unclear. We aimed to investigate health behaviors, obesity, psychotropic medication use, and comorbidity as potential mediating mechanisms explaining these associations. Methods We combined data from a large population-based survey with register-based data and followed
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Environmental exposures and blood pressure in adolescents and adults in the T1D exchange clinic registry J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-08-25 Stephanie Griggs, Grant Pignatiello, Issam Motairek, Jorden Rieke, Quiana Howard, Sybil L. Crawford, Sanjay Rajagopalan, Sadeer Al-Kindi, Ronald L. Hickman
Aims To examine the associations between environmental determinants of health and blood pressure and whether age, sex, or race moderated the associations among 18,754 adolescents and adults from the type 1 diabetes (T1D) Exchange Clinic Registry. Methods We used multivariable linear regression. Environmental determinants included exposure to ambient fine particulate matter (PM2.5, obtained from an
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Increased intracellular miR-142 in adults with Type 1 diabetes J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-08-25 Li Huang, Andrzej S. Januszewski, Yusuke Takahashi, David N. O'Neal, Jian-Xing Ma, Alicia J. Jenkins
microRNAs (miRs), including miR-142, modulate gene expression and processes implicated in vascular damage and may serve as therapeutic targets and agents, including in Type 1 diabetes (T1D). The project aimed to assess whether miR-142 levels differ between people with and without T1D, and to analyse miR-142 associations with cardiovascular (CVD) risk factors. Intracellular miRs were isolated from whole
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Longitudinal bidirectional associations between diabetic retinopathy and diagnosed depression: Results from a Danish nationwide registry-based cohort study J. Diabetes its Complicat. (IF 3.0) Pub Date : 2023-08-24 Frederik N. Pedersen, Lonny Stokholm, Nis Andersen, Jens Andresen, Toke Bek, Javad N. Hajari, Steffen Heegaard, Kurt Højlund, Ryo Kawasaki, Sören Möller, Caroline S. Laugesen, Katja C. Schielke, Anne S. Thykjær, Tunde Peto, Frans Pouwer, Jakob Grauslund
Objective Diabetic retinopathy (DR) is a feared complication and a leading course of visual impairment, but the connection between DR and depression including the direction has never been studied in a nationwide cohort. We aimed to assess, whether the associations between DR and diagnosed depression are bidirectional. Methods We performed a national register-based cohort study of individuals with type