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Evaluation of the Quality of Life in Moroccan Patients Diagnosed with Hypoparathyroidism Int. J. Endocrinol. (IF 2.8) Pub Date : 2024-4-16 Mohammed-Amine Essafi, Samira Handa, Hayat Aynaou, Houda Salhi
Objective. Hypoparathyroidism (HPt) is a rare endocrine disorder often of postsurgical origin, resulting in hypocalcaemia. Several complications have been described including impairment of quality of life (QoL). Our study aims to evaluate the effect of hypoparathyroidism on the QoL of patients diagnosed with HPt. Methods. A cross-sectional study was conducted in the Department of Endocrinology, Diabetology
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Metabolomics of Mice with Type 2 Diabetes and Nonalcoholic Fatty Liver Treated by Acupuncture Int. J. Endocrinol. (IF 2.8) Pub Date : 2024-4-10 Yihui Guo, Liying Zhang, Mengyuan Li, Linan Lin, Fuyu Xue, Wanning Gao, Xiaoru Xu, Haipeng Huang
Introduction. To investigate the effects of acupuncture on endogenous metabolites in the liver of type 2 diabetes mellitus (T2DM) with nonalcoholic fatty liver disease (NAFLD) mice-based metabolomics. Methods. Proton nuclear magnetic resonance (1H-NMR) metabolomics combined with multivariate statistical analysis and univariate analysis were used to analyze the changes of endogenous metabolites in the
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Parathyroid Hormone is Negatively Correlated with Glycated Hemoglobin in Newly Diagnosed Type 2 Diabetic Patients Int. J. Endocrinol. (IF 2.8) Pub Date : 2024-4-1 Xueqing He, Man Liu, Xiaoyu Ding, Nannan Bian, Jiaxuan Wang, Guang Wang, Jia Liu
Objective. The growing evidence shows that parathyroid hormone (PTH) may affect glucose metabolism. However, the relationship between them is still controversial among diabetic patients. The current study aimed to investigate the relationship between PTH and glucose metabolism in the patients with newly diagnosed type 2 diabetes (T2D). Methods. A total of 532 participants, including 387 patients with
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Associations of Combined Exposure to Metabolic and Inflammatory Indicators with Thyroid Nodules in Adults: A Nested Case-Control Study Int. J. Endocrinol. (IF 2.8) Pub Date : 2024-3-27 Xin-Yi Zhu, Xing-Chen Meng, Bei-Jing Cheng, Chun Wang, Jia Wang, Tian-Lin Li, Hui Li, Ke Meng, Ran Liu
Objective. To explore associations of combined exposure to metabolic/inflammatory indicators with thyroid nodules. Methods. We reviewed personal data for health screenings from 2020 to 2021. A propensity score matching method was used to match 931 adults recently diagnosed with thyroid nodules in a 1 : 4 ratio based on age and gender. Conditional logistic regression and Bayesian kernel machine regression
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Coenzyme Q10: A Key Antioxidant in the Management of Diabetes-Induced Cardiovascular Complications—An Overview of Mechanisms and Clinical Evidence Int. J. Endocrinol. (IF 2.8) Pub Date : 2024-3-15 Fatemeh Samimi, Nasim Namiranian, Ali Sharifi-Rigi, Morvarid Siri, Omid Abazari, Sanaz Dastghaib
Background. Diabetes mellitus (DM) presents a significant global health challenge with considerable cardiovascular implications. Coenzyme Q10 (CoQ10) has gained recognition for its potential as a natural antioxidant supplement in the management of diabetes and its associated cardiovascular complications. Aim. This comprehensive review systematically examines the scientific rationale underlying the
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Association between Glycosylated Hemoglobin and Serum Uric Acid: A US NHANES 2011–2020 Int. J. Endocrinol. (IF 2.8) Pub Date : 2024-3-14 Huan Li, Mingliang Sun, Chengcheng Huang, Jingwu Wang, Yanqin Huang
Background. Serum uric acid (SUA) and glycosylated hemoglobin (HbA1c) were closely related to the body’s metabolism. This study aimed to investigate the relationship between HbA1c and SUA in adults. Methods. This study selected 7293 participants aged ≥20 from 2011 to 2020 in the National Health and Nutrition Examination Survey (NHANES). The multivariate linear regression model was used to test the
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Comparative Effectiveness of Antidiabetic Drugs as an Additional Therapy to Metformin in Women with Polycystic Ovary Syndrome: A Systematic Review of Metabolic Approaches Int. J. Endocrinol. (IF 2.8) Pub Date : 2024-3-11 Maryam Heidarpour, Mehrzad Mojarad, Sadegh Mazaheri-Tehrani, Ali Kachuei, Arash Najimi, Davood Shafie, Hassan Rezvanian
Background. Metformin is commonly prescribed to treat polycystic ovary syndrome (PCOS) patients, but in some cases, it may not be effective even at high doses or may cause intolerable side effects. Therefore, recent studies have examined the impact of combining metformin with other antidiabetic medications. Methods. A systematic search was performed in Scopus, PubMed, Web of Science, and Embase up
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Retrospective Analysis of the Efficacy and Safety of Ultrasound-Guided Radiofrequency Ablation in the Treatment of Papillary Thyroid Microcarcinoma: A Follow-Up Study of Continuous Postoperative Surveillance and Large-Sample Data Int. J. Endocrinol. (IF 2.8) Pub Date : 2024-3-6 Gongli Zhou, Xuefeng Zhang, Ke Xu, Beibei Zhang, Ruiqing Su, Tingting Cai, Wei Zhao, Feng Li
Objective. To retrospectively evaluate the efficacy and safety of ultrasound-guided radiofrequency ablation (RFA) in the treatment of papillary thyroid microcarcinoma (PTMC) through a follow-up study of continuous postoperative surveillance and large-sample data. Methods. The efficacy of ultrasound-guided RFA was evaluated by measuring the tumor volume reduction rate (VRR), tumor disappearance rate
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Prevalence of Hypogonadism and Associated Risk Factors among Newly Diagnosed ART Naïve HIV-Infected Males in Mwanza, Tanzania Int. J. Endocrinol. (IF 2.8) Pub Date : 2024-3-5 Shabani Iddi, Haruna Dika, Benson Kidenya, Samuel Kalluvya
Background. Hypogonadism is frequent among HIV-infected males and might have significant clinical impact leading to sexual impairment and metabolic derangement. There is limited information about the magnitude of hypogonadism and its associated factors among people living with HIV in Tanzania. We aimed to determine the prevalence of hypogonadism and associated risk factors among newly diagnosed ART
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Effect of the AADE7 Self-Care Behaviors Framework on Diabetes Education Management in a Shared Care Model Int. J. Endocrinol. (IF 2.8) Pub Date : 2024-3-1 Yunxia Liu, Chenhui Liu
Background. Diabetes self-management education (DSME) provides diabetic patients with knowledge of diabetes, requires attention and recording of dietary habits, and increases the frequency and accuracy of blood glucose monitoring. DSME also achieves better blood glucose control, thus benefiting diabetic patients and reducing the risk of diabetes complications. However, few studies have systematically
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Higher Atherogenic Index of Plasma Is Associated with Hyperuricemia: A National Longitudinal Study Int. J. Endocrinol. (IF 2.8) Pub Date : 2024-2-19 Feifei Xu, Chengyong Ma, Shouping Wang, Qin Li, Zhongwei Zhang, Min He
Background. The association between atherogenic index of plasma (AIP) and hyperuricemia remains indistinct. This study was aimed to examine the relationship between AIP and hyperuricemia among the middle-aged and the elderly Chinese population. Methods. Datasets were retrieved from the China Health and Retirement Longitudinal Study (CHARLS) survey conducted in 2011 and 2015. 13,021 participants in
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Relationship between Serum Indoxyl Sulfate and Klotho Protein and Vascular Calcification in Patients with Chronic Kidney Disease Stages 3–5 Int. J. Endocrinol. (IF 2.8) Pub Date : 2024-2-14 Yan Gao, Cong-Juan Zhao, Qiang Liu, Chen-chen Li, Zhe Li, Jing Li, Qian Wang, Li Zhang
Objective. This study aims to explore the relationships between serum indoxyl sulfate (IS) and Klotho protein levels with vascular calcification in patients with chronic kidney disease (CKD) stages 3–5. Methods. From December 2021 to January 2023, a total of 108 CKD patients in stages 3–5 were enrolled in this cross-sectional investigation. Demographic information and routine clinical biochemistry
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Effects of DPP4 Inhibitors as Neuroprotective Drug on Cognitive Impairment in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis and Systematic Review Int. J. Endocrinol. (IF 2.8) Pub Date : 2024-2-13 Yuting Yuan, Yue Zhang, Min Lei, Xiying Guo, Xiaosong Yang, Changhan Ouyang, Chao Liu, Qingjie Chen
Purpose. Type 2 diabetes mellitus is considered as one of the risk factors for cognitive impairment. DPP4 inhibitors are effective drugs for the treatment of type 2 diabetes mellitus. However, the relationship between DPP4 inhibitors and cognitive dysfunction remains unclear. Therefore, we used a meta-analysis to determine the association between DPP4 inhibitors and cognitive impairment in type 2 diabetes
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Light and Shadow of Na-Glucose Cotransporter 2 Inhibitors in the Treatment of Diabetes Mellitus: Points for Improvement Based on Our Clinical Experience Int. J. Endocrinol. (IF 2.8) Pub Date : 2024-1-25 Akihiro Sonoda, Toshio Shimada, Kohei Saito, Rieko Kosugi, Yoshitaka Taguchi, Tatsuhide Inoue
We analyzed the effect of Na-glucose cotransporter 2 inhibitors (SGLT2-I) in diabetic patients visiting our hospital. The study included 236 patients treated with SGLT2-I alone or with codiabetic drugs for at least two years. We analyzed overtime changes in glycosylated hemoglobin A1c (HbA1c) in the patients by repeated analyses of variance (ANOVA) and evaluated the therapeutic effect. HbA1c levels
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Whether Detection of Gene Mutations Could Identify Low- or High-Risk Papillary Thyroid Microcarcinoma? Data from 393 Cases Using the Next-Generation Sequencing Int. J. Endocrinol. (IF 2.8) Pub Date : 2024-1-16 Lei Jin, Liang Zhou, Jian-Biao Wang, Li Tao, Xiao-Xiao Lu, Na Yan, Qian-Ming Chen, Li-Ping Cao, Lei Xie
Objective. The objective of this study is to explore the utilization of next-generation sequencing (NGS) technology in evaluating the likelihood of identifying individuals with papillary thyroid microcarcinoma (PTMC ≤10 mm) who are at high or low risk. Design. NGS was used to analyze 393 formalin-fixed, paraffin-embedded tissues of PTC tumors, all of which were smaller than 15 mm. Results. The study
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Machine Learning for Predicting Distant Metastasis of Medullary Thyroid Carcinoma Using the SEER Database Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-12-30 Zhen-Tian Guo, Kun Tian, Xi-Yuan Xie, Yu-Hang Zhang, De-Bao Fang
Objectives. We aimed to establish an effective machine learning (ML) model for predicting the risk of distant metastasis (DM) in medullary thyroid carcinoma (MTC). Methods. Demographic data of MTC patients were extracted from the Surveillance, Epidemiology, and End Results (SEER) database of the National Institutes of Health between 2004 and 2015 to develop six ML algorithm models. Models were evaluated
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Expression and Clinical Significance of Plasma miR-223 in Patients with Diabetic Nephropathy Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-12-27 Xingrong Guo, Meiying Huang, Dawei Yang, Zuojie Luo
Background. MicroRNA-223 (miR-223) is associated with diabetes and kidney diseases and serves as a novel marker for diagnosing diabetic kidney disease (DKD). This study was conducted to investigate the plasma expression of miR-223 and its clinical significance in type 2 diabetes (T2DM) and diabetic nephropathy (DN) patients. Methods. In this research, 20 patients with T2DM and DN, 19 patients with
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Effects of a Novel Glucokinase Activator, Dorzagliatin, on Glycemic Control and Glucose Fluctuation in Drug-Naïve Patients with Type 2 Diabetes Mellitus Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-12-27 Yuming Wang, Xiaofei Su, Wenli Zhang, Yunting Zhou, Xiao Zhou, Wei Yang, Huiqin Li, Jianhua Ma
Aim. The prevalence rate of type 2 diabetes mellitus (T2DM) has been increasing and a large proportion of patients still do not achieve adequate or sustainable glycemic control on the basis of previous hypoglycemic treatment. In this present study, we explored whether dorzagliatin, a novel glucokinase activator (GKA), could improve glycemic control and lessen glucose fluctuation in drug-naïve patients
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Current Status of Metabolic Compliance and Risk of Cardiovascular Disease in Patients with Type 2 Diabetes in the Zhuang Population in China Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-12-22 Danqing Xu, Xia Dai, Qiong Yang, Xueying Li, Ying Xiao, Qiuhong Huang, undefined Qingqing Lou
Introduction. This study aimed to investigate the blood glucose, blood pressure, and blood lipid status in Zhuang patients with T2DM and to analyze the correlation between compliance with metabolic monitoring and cardiovascular risk factors. Methods. A total of 1975 Zhuang patients with T2DM were evaluated in four Class III Grade A hospitals in three prefecture-level cities in the Guangxi Zhuang Autonomous
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Adrenal Vein Sampling in the Management of Primary Aldosteronism: The Added Value of Intraprocedural Cortisol Assessment Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-12-21 Inês Manique, Sara Amaral, Alexandra Matias, Bruno Bouça, Salomé Serranito, João Torres, Olga Gutu, Tiago Bilhim, Élia Coimbra, Isaura Rodrigues, Conceição Godinho, Luísa Cortez, José Silva-Nunes
Introduction. Primary aldosteronism is the most common cause of secondary hypertension. Adrenal vein sampling is the gold standard for subtyping primary aldosteronism. However, this procedure is technically challenging and often has a low success rate. Our center is one of the very few performing this technique in our country with an increasing experience. Objective. The aim of this study was to evaluate
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Factors Influencing a Favorable Outcome for RFA of Huge Benign Thyroid Nodules: Preliminary Results and Short-Term Evaluation Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-12-14 Chun-Hua Chiu, Sheng-Dean Luo, Pi-Ling Chiang, An-Ni Lin, Cheng-Kang Wang, Chen-Kai Chou, Shun-Yu Chi, Meng-Hsiang Chen, Wei-Che Lin
Objective. This study aimed to investigate potentially favorable factors influencing the therapeutic success of radiofrequency ablation (RFA) of huge benign thyroid nodules (BTNs) (volume >100 ml) and to evaluate the feasibility of RFA as an alternative treatment modality for patients unable or unwilling to undergo surgery. Methods. This retrospective study evaluated a total of 868 patients, of which
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GLP1R rs3765467 Polymorphism Is Associated with the Risk of Early Onset Type 2 Diabetes Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-12-14 Yunyun Fang, Jingjing Zhang, Linlin Ji, Chaoyu Zhu, Yuanyuan Xiao, Qingge Gao, Wenjing Song, Li Wei
Objective. To investigate the relationship between glucagon-like peptide-1 receptor gene polymorphisms and susceptibility to early onset type 2 diabetes. Methods. Samples from 316 type 2 diabetes patients with early onset type 2 diabetes (n = 137) and late-onset type 2 diabetes (n = 179) and 145 nondiabetic individuals were analyzed. Multiplex PCR combined with resequencing Hi-Reseq technology was
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Action Mechanisms of Metformin Combined with Exenatide and Metformin Only in the Treatment of PCOS in Obese Patients Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-12-14 Jingwen Gan, Jie Chen, Rui-lin Ma, Yan Deng, Xue-song Ding, Shi-yang Zhu, Ai-jun Sun
Background. Polycystic ovary syndrome (PCOS) is the most common endocrine disease in women of reproductive age, whose clinical characteristics are hyperandrogenism (HA), ovulatory dysfunction, and polycystic ovary, often accompanied by insulin resistance (IR) and metabolic abnormalities. Glucagon-like peptide (GLP)-1 receptor agonists (GLP-1Ra), such as exenatide, can bind to specific receptors on
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Elevated Thyroglobulin Antibody Level is Associated with Decreased Anti-Müllerian Hormone in Women of Reproductive Age Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-12-13 Jazyra Zynat, Xinling Wang, Li Han, Shuqing Xing, Guzailinuer Jvlaiti, Qingqing Liu, Lingling Dong, Yanying Guo
Purpose. Women with Hashimoto’s thyroiditis (HT) have an increased risk of ovarian insufficiency. However, whether thyroid antibodies affect the ovarian reserve remains controversial. The aim of this study was to explore the possible relationship between anti-Müllerian hormone (AMH) and thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) levels in women of reproductive age. Methods
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Calcium Activation of the Androgen Receptor in Prostate Cells Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-12-13 Zeina W. Sharawi, Sawsan M. Khatrawi, Qiaochu Wang, Hongzhao Zhou, Kedra Cyrus, Gai Yan, Becky Hoxter, Bassem R. Haddad, Mary Beth Martin
Background. Although prostate cancer patients initially respond to androgen deprivation therapy, most patients progress to a resistant phenotype. Castration resistance is due, in part, to intratumoral and/or adrenal synthesis of androgens, overexpression or mutation of the androgen receptor (AR), stabilization of AR by chaperones, and ligand-independent activation of AR. Increasing evidence also links
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Vitamin D Deficiency and the Presentation of Primary Hyperparathyroidism: A Mini Review Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-12-11 Niharika Yedla, Hyon Kim, Anupa Sharma, Xiangbing Wang
The clinical presentation of primary hyperparathyroidism (PHPT) has evolved over the years from a symptomatic disorder to a predominantly asymptomatic condition. Altered vitamin D metabolism seems to play a role in the presentation of PHPT and may exacerbate the severity of disease. The epidemiology of PHPT differs in the developing versus the developed world, where more severe phenotypes occur in
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Progress in Prevention and Treatment of Acute Bone Loss in Orthopedics Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-11-30 Haoran Wang, Ji Wu, Boyao Wang, Hu Qin, Lei Fan, Yunhua Wang, Bin He
Orthopedic patients need to perform limb immobilization for several days to several weeks due to fracture or other special circumstances. When the function of a certain part or the whole body is restricted, the activity of osteoclasts will be enhanced and its life activity will surpass that of osteoblasts, so local or even whole body bone loss will occur. Acute bone loss usually occurs within a few
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Association between Sleep Duration and Left Ventricular Hypertrophy for Patients with Type 2 Diabetes Mellitus Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-11-28 Lin Mu, Chao Li, Wenying Zhao, Aihua Li, Dong Zhao, Baoyu Zhang
Objective. In this study, we aimed to estimate the impact of sleep duration on left ventricular hypertrophy (LVH) in type 2 diabetes mellitus (T2DM). Methods. Consecutive patients with T2DM undergoing transthoracic echocardiography (TTE) in our center from October 2017 to February 2021 were analyzed. The association of the risk of LVH in T2DM patients was evaluated using univariable and multivariable
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Variations in the Urinary Iodine Concentration and Urinary Iodine/Creatinine Ratio among Preschool Children Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-11-23 Dong An, Rui Yang, Yuping Du, Xuan Wang, Ying Yang, Wenxing Guo, Junhong Yang, Dongmei Meng, Weiwei Gao, Jiayi Zhang, Wen Chen, Wanqi Zhang
Variations in different urinary measurements for evaluating iodine status are concerning to clinicians and researchers. The present study aimed to analyze the interindividual and intraindividual variations in the urinary iodine concentration (UIC) and urinary iodine/creatinine (UI/Cr) ratio and evaluate their application in assessing the iodine nutrition of preschool children. Four repeated spot urine
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Diagnostic Accuracy of the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC): An Institution Experience Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-11-15 Karima Rai, Joseph Park, Shamika Gokhale, Fatima Irshaidat, Gurdeep Singh
The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is a standardized system which is used to classify results of thyroid fine-needle aspiration (FNA). This system is used to evaluate and determine which patients should get thyroid surgery. It was created in order to reduce the number of patients requiring surgery. The question remains as to whether this reporting system is accurate in
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Diabetes Mellitus across the Arabo-Islamic World: A Revolution Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-11-10 Mohamad Fleifel, Bassem Fleifel, Andrew El Alam
Background. Mankind continues to suffer from the ever-growing diabetes epidemic and the rapid rise of type 2 diabetes mellitus (T2DM). This metabolic disease has been studied since ancient civilizations. The Arabo-Islamic civilization excelled in establishing some of the most notable discoveries and teachings that remained the blueprint for years to come in the field of diabetology. Aim. This article
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The Association between Visit-to-Visit Variability of Blood Pressure and the Risk of Metabolic Syndrome: The Moderating Effect of Weight Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-10-27 Ruxue Li, Wuai Zhou, Xue Cai, Dan Luo, Huijing Zhang, Mingzi Li
Aims. Metabolic syndrome (MetS) affects approximately one-third of the global population. Visit-to-visit variability of blood pressure (VVV-BP) constitutes a substantial risk factor for numerous chronic conditions. Thus, this study aimed to assess the relationship between VVV-BP and MetS and identify potential moderating factors between these. Methods. Data were obtained from the China Health and Retirement
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Factors Associated with Vitamin D Deficiency and Their Relative Importance among Indian Adolescents: An Application of Dominance Analysis Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-10-17 Akif Mustafa, Chander Shekhar
Vitamin D deficiency is a serious issue in developing nations, including India. This study investigates the determinants of vitamin D deficiency among Indian adolescents and assesses their relative importance using dominance analysis. Data from the Comprehensive National Nutrition Survey (CNNS) conducted between 2016 and 2018 were utilized in this study. Vitamin D levels were assessed based on serum
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Analysis of Subclinical Thyroid Dysfunction and Metabolic Abnormality in 28568 Healthy People Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-10-16 Yan Xie, Zhixue Wang, Zongtao Chen
We analyzed the detection rates of metabolic syndrome (MetS) and subclinical thyroid dysfunction, including subclinical hyperthyroidism (SCHyper) and subclinical hypothyroidism (SCH), in healthy people, as well as their relationship. Clinical data were collected from 28,568 healthy individuals who underwent physical examinations. The detection rates of SCHyper, SCH, and MetS, as well as in different
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Sildenafil Enhances the Therapeutic Effect of Islet Transplantation for Diabetic Peripheral Neuropathy via mTOR/S6K1 Pathway Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-10-7 Xiandong Zhu, Shangjing Xie, Jiawei Chen, Qiaohong Lu, Xiaowu Wang, Feixiang Duan, Sinian Xu, Yan Zhang, Hongjian Huang, Yongqiang Wang, Hongwei Wang, Bicheng Chen, Huanjie Huang
Purpose. This study aimed to investigate the potential mechanism underlying the therapeutic effect of sildenafil in combination with islet transplantation for diabetic peripheral neuropathy. Methods. A streptozotocin-induced diabetic mouse model was established to evaluate the effects of islet transplantation and sildenafil intervention. The mice were subjected to different interventions for 6 weeks
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Incidence of Dysmagnesemia among Medically Hospitalized Patients and Associated Clinical Characteristics: A Prospective Cohort Study Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-10-4 Zahra Al Shukri, Juhaina Salim Al-Maqbali, Abdullah M. Al Alawi, Nafila Al Riyami, Sulaiman Al Riyami, Hiba Al Alawi, Qatiba Al Farai, Henrik Falhammar
Background. Magnesium (Mg) disorders are common among hospitalized patients and are linked to poor health outcomes. We aimed to determine the incidence of dysmagnesemia among medically hospitalized patients and to identify factors that are associated with dysmagnesemia. Methods. A prospective cohort study was conducted at Sultan Qaboos University Hospital (SQUH) from April 1st, 2022, to October 31st
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Adrenal Hemorrhage in Patients with Systemic Lupus Erythematosus and Antiphospholipid Syndrome: A Case Report and Literature Review Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-9-26 Weiwei Jiang, Danrui Chen, Daizhi Yang, Longyi Zeng, Wen Xu, Shuo Lin
Antiphospholipid syndrome (APS) is an autoimmune disorder while adrenal hemorrhage could be its rare complication. Herein, we report the case of a 32-year-old unmarried woman with a history of systemic lupus erythematosus (SLE) who was hospitalized after complaints of upper abdominal pain, limb weakness, and loss of appetite for 2 weeks. Laboratory examination revealed hyponatremia, low plasma cortisol
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Atypical Femoral Fracture in Hypophosphatasia: A Systematic Review Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-9-12 Nipith Charoenngam, Jerapas Thongpiya, Pitchaporn Yingchoncharoen, Ben Ponvilawan, Mehmet S. Marangoz, Jirat Chenbhanich, Patompong Ungprasert
Objective. To summarize the characteristics of all reported patients with hypophosphatasia (HPP) who sustained atypical femoral fracture (AFF) and identify all available evidence to quantify the rate of coexistence between HPP and AFF. Methods. Potentially eligible articles were identified from the MEDLINE and EMBASE databases from its inception to September 2022, using a search strategy consisting
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Identification of Risk Factors and Development of a Predictive Model for Postoperative Hypoglycemia among Diabetic Patients during the Perioperative Period Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-8-29 Zixuan Liu, Jing Dai, Xiaodie He, Jiaxi Li, Haixia Zhang, Cheng Ji
Objective. To explore the incidence and influencing factors of postoperative hypoglycemia in diabetic patients during the perioperative period and to construct a risk prediction model for postoperative hypoglycemia. Methods. Patients with T2DM admitted to the nonendocrinology department of Nanjing Drum Tower Hospital from December 2019 to January 2022 were included as research subjects. Basic information
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Composite Dietary Antioxidant Index Is Negatively Associated with Hyperuricemia in US Adults: An Analysis of NHANES 2007–2018 Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-8-17 Zhenzong Lin, Haokai Chen, Qiwen Lan, Yinghan Chen, Wanzhe Liao, Xuguang Guo
Hyperuricemia and its complications are severe risks to human health. Dietary intervention is considered an essential part of the management of hyperuricemia. Studies have reported that the intake of antioxidants has a positive effect on hyperuricemia. Here, we collected data from 8761 participants of the National Health and Nutrition Examination Survey for this analysis. Daily intakes of vitamins
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Dulaglutide Protects Mice against Diabetic Sarcopenia-Mediated Muscle Injury by Inhibiting Inflammation and Regulating the Differentiation of Myoblasts Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-8-7 Fengyi Deng, Wenyan Wu, Xingyu Fan, Xing Zhong, Nuojin Wang, Yue Wang, Tianrong Pan, Yijun Du
Background. Type 2 diabetes mellitus increases the risk of sarcopenia, which is characterized by decreased muscle mass, strength, and function. However, there are no effective drugs to treat diabetic sarcopenia, and its underlying mechanism remains unknown. Here, we aimed to determine whether the GLP-1 receptor agonist (GLP-1RA) dulaglutide (Dul) affects the progression of diabetic sarcopenia. Methods
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Glucose Metabolism Indices and the Development of Chronic Kidney Disease: A Cohort Study of Middle-Aged and Elderly Chinese Persons Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-8-2 Lili You, Xiaosi Hong, Qiling Feng, Kan Sun, Diaozhu Lin, Chulin Huang, Chaogang Chen, Chuan Wang, Guojuan Lao, Shengneng Xue, Juying Tang, Na Li, Yiqin Qi, Wanting Feng, Feng Li, Chuan Yang, Mingtong Xu, Yan Li, Li Yan, Meng Ren
Objective. Chronic kidney disease (CKD) has become a major global health issue, and abnormalities of glucose metabolism are a risk factor responsible for development of CKD. We aimed to investigate associations between glucose metabolism indices and CKD in a Chinese population and determine which index is superior for predicting incident CKD. Methods. We performed a community-based population on 5232
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Relationship between Uric Acid to High Density Lipoprotein Cholesterol Ratio and Nonalcoholic Fatty Liver Disease in Nonoverweight/Obese Patients with Type 2 Diabetes Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-8-1 Yuliang Cui, Zhenzhen Qu, Wenmei Hu, Haiyan Shi
Aims. To investigate the relationship between uric acid to high-density lipoprotein cholesterol ratio (UHR) levels and nonalcoholic fatty liver disease (NAFLD) in nonoverweight/obese patients with type 2 diabetes. Methods. A retrospective study was designed including a total of 343 inpatients with type 2 diabetes whose BMI<24 kg/m2. The population was divided into three groups as the UHR tertiles.
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Bone Turnover Markers in Adults with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-7-19 Chao Li, Yali Cui, Wenjie Zhou, Yiduo Zhang, Xiaocui Huang, Fan Yu
Objective. Previous studies suggested that the level of bone turnover markers (BTMs) could be altered in patients with nonalcoholic fatty liver disease (NAFLD). We aim to provide a comprehensive understanding on the associations between BTMs and NAFLD in adults with a meta-analysis. Methods. Articles published up to January 31, 2023, were systematically searched in PubMed, Web of Science, Cochrane
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Chemical Characterization and Ameliorating Effect of Centratherum anthelminticum Extract against Polycystic Ovary Syndrome in Wistar Rats Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-7-13 Moonis Shoaib, Ammara Saleem, Alam Zeb, Muhammad Imran Khan, Muhammad Furqan Akhtar
Polycystic ovary syndrome (PCOS) in females is an endocrine pathological condition of reproductive age which is usually caused by insulin resistance, hyperlipidemia, and oxidative stress. This research was aimed at evaluating the therapeutic effect of the Centratherum anthelminticum seed extract (CA) against PCOS in rodents as it is traditionally used to treat diabetes, inflammation, and gynecological
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Diabetic Ketoacidosis Associated with Sodium-Glucose Cotransporter 2 Inhibitors: Clinical and Biochemical Characteristics of 29 Cases Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-7-4 G. A. Stamatiades, P. D’Silva, M. Elahee, G. M. Viana, A. Sideri-Gugger, S. K. Majumdar
Context. Numerous reports suggest an association between SGLT2 inhibitors and DKA. Since the use of these drugs for diabetes has increased dramatically, identification of patients at greatest risk of this life-threatening complication is essential. Objective. To describe the clinical and biochemical characteristics of all reported cases of DKA associated with SGLT2 inhibitor use in patients with type
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Association of IGF-1 Level with Low Bone Mass in Young Patients with Cushing’s Disease Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-7-4 Wanwan Sun, Quanya Sun, Qiaoli Cui, Min He, Wei Wu, Yiming Li, Hongying Ye, Shuo Zhang
Purpose. Few related factors of low bone mass in Cushing’s disease (CD) have been identified so far, and relevant sufficient powered studies in CD patients are rare. On account of the scarcity of data, we performed a well-powered study to identify related factors associated with low bone mass in young CD patients. Methods. This retrospective study included 153 CD patients (33 males and 120 females
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DHA Supplementation during Pregnancy in Women with Obesity Normalizes IGF2R Levels in the Placenta of Male Newborns Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-6-27 Juan José Castro, Adriana Umana-Perez, Erika Castaño-Moreno, Paola Casanello, Ana María Ronco
Introduction. Insulin-like growth factor receptor 2 (IGF2R) regulates placental nutrient transport, and its soluble form is related to obesity in adults. If the placental expression of IGF2R is altered in women with obesity is unknown. Whether maternal supplementation with docosahexaenoic acid (DHA), a polyunsaturated fatty acid with anti-inflammatory properties, has a modulatory role in IGF2R’s function
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Association between the Triglyceride Glucose Index and Hyperuricemia in Patients with Primary Hypertension: A Cross-Sectional Study Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-6-15 Shanshan Liu, Zhixian Zhou, Miao Wu, Hao Zhang, Yao Xiao
Objective. The aim of this study was to investigate the association between the triglyceride glucose (TyG) index and hyperuricemia (HUA) in patients with grades 1–3 hypertension. Study Design. This is a cross-sectional study. A total of 1,707 patients from the cardiovascular department of Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine were studied. In this study, 899 patients
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Clinical and Functional Characterization of Novel AGL Variants in Two Families with Glycogen Storage Disease Type III Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-5-30 Tingting Yu, Hao Fu, Aoyu Yang, Yan Liang
Purpose. Glycogen storage disease type III (GSDIII) is a uncommon autosomal recessive inherited metabolic disorder, which is caused by variants in the AGL gene. The purpose of this study was to elucidate the clinical and functional features of two novel variants in two families with GSDIIIa. Methods. We collected the clinical and laboratory data of the two patients. Genetic testing was performed using
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Adiponectin Gene Polymorphisms and Possible Susceptibility to Metabolic Syndrome among the Sudanese Population: A Case-Control Study Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-4-27 Altaf S. Mosad, Ghada A. Elfadil, Alsadig Gassoum, Khanssa M. Elamin, Nazik Elmalaika Obaid Seid Ahmed Husain
Background and Aim. The adiponectin gene (ADIPQ) has been identified as a human adiposity marker of metabolic syndrome (MetS) in several ethnic cultures. This study aimed to determine the allelic genotypes and haplotypes distribution of the ADIPQ gene polymorphisms and its association with body mass index (BMI), waist circumference (WC), glycated hemoglobin (HbA1c), and lipid profile in MetS adult
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Surgical Management of Giant Prolactinomas: A Descriptive Study Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-4-25 Michelle D. Lundholm, Divya Yogi-Morren, Kevin M. Pantalone, Pablo F. Recinos, Varun R. Kshettry, Pratibha P. R. Rao
Introduction. Giant prolactinoma (GP) is a rare pituitary lactotropic cell tumor larger than 4 cm in its widest dimension, and is less likely than a smaller prolactinoma to achieve prolactin normalization on dopamine agonist (DA) monotherapy. There is a paucity of data on the circumstances and outcomes of second-line management of GP with surgery. Herein, our institution’s experience with the surgical
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Research Progress on Mesenchymal Stem Cells for the Treatment of Diabetes and Its Complications Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-4-24 Jiarui Zhang, Yongqin Zheng, Lichenlu Huang, Jundong He
Diabetes mellitus (DM) is a chronic disease that threatens human health. Although many drugs are available to treat DM, various complications caused by DM are unavoidable. As an emerging treatment for DM, mesenchymal stem cells (MSCs) have shown many advantages and are gradually gaining public attention. This review summarizes the clinical studies on the use of MSCs to treat DM and the potential mechanisms
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Severe Obesity in Women Can Lead to Worse Memory Function and Iron Dyshomeostasis Compared to Lower Grade Obesity Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-4-17 Jessica M. V. Pino, Vitória F. Silva, Marcos Mônico-Neto, Danielle C. Seva, Melissa Y. Kato, July N. Alves, Gabriela C. Pereira, Hanna Karen M. Antunes, Thales D. Galvao, Lia R. A. Bitterncourt, Sergio Tufik, Lysien I. Zambrano, Ana R. Dâmaso, Lila M. Oyama, David Thivel, Raquel M. S. Campos, Kil S. Lee
Objective. Obesity is one of the modifiable risk factors for dementia. Insulin resistance, the abundance of advanced glycated end-products, and inflammation are some of the mechanisms associated with the lower cognitive performance observed in obesity. This study aims to evaluate the cognitive function of subjects with distinct degrees of obesity, comparing class I and II obesity (OBI/II) to class
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MAFLD in Patients with Cushing’s Disease Is Negatively Associated with Low Free Thyroxine Levels Rather than with Cortisol or TSH Levels Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-4-12 Kuangyang Chen, Lijiao Chen, Jiarong Dai, Hongying Ye
Purpose. This study aims to analyze the clinical characteristic of metabolic associated fatty liver disease (MAFLD) in patients with active Cushing’s disease (CD) and determine associations of thyroid hormones with MAFLD. Methods. Patients with active CD were included in this cross-sectional study. All subjects were assessed for hepatic steatosis by abdominal ultrasonography and thyroid functions.
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Immunocytochemistry Profile of Benign Thyroid Nodules Not Responding to Thermal Ablation: A Retrospective Study Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-4-11 Stella Bernardi, Silvia Taccogna, Martina D’Angelo, Fabiola Giudici, Giovanni Mauri, Bruno Raggiunti, Doris Tina, Fabrizio Zanconati, Enrico Papini, Roberto Negro
Purpose. Thermal ablations (TA) are gaining ground as alternative options to conventional therapies for symptomatic benign thyroid nodules. Little is known about the impact of nodule biology on the outcomes of TA. The aim of our study was to evaluate the baseline immunocytochemistry profile of thyroid nodules that were poorly responsive to TA in order to identify potential predictors of the treatment
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Risk Factors for Granulocytopenia in Patients with Graves’ Disease Receiving Antithyroid Drugs Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-4-10 Jiaxi Li, Xiaowen Zhang, Lintong Li, Qiaoling Zhu, Weihong Ge, Cheng Ji
Objective. To study the risk factors for granulocytopenia caused by antithyroid drugs. Methods. Patients who were diagnosed with Graves’ hyperthyroidism and regularly treated with antithyroid drugs (ATDs) from January 2010 to July 2022 at Nanjing Drum Tower Hospital, aged >18 years, were selected for general information and laboratory tests and divided into two groups according to the occurrence of
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Effects of Growth Hormone on Adult Human Gonads: Action on Reproduction and Sexual Function Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-4-7 Xin-Yi Zhou, Jia-Ni Ma, Ya-Yin Shen, Xue-Rui Xie, Wei Ren
Growth hormone (GH), which is commonly considered to be a promoter of growth and development, has direct and indirect effects on adult gonads that influence reproduction and sexual function of humans and nonhumans. GH receptors are expressed in adult gonads in some species including humans. For males, GH can improve the sensitivity of gonadotropins, contribute to testicular steroidogenesis, influence
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Effects of 18 Months of Growth Hormone Replacement Therapy on Bone Mineral Density in Patients with Adult Growth Hormone Deficiency: A Retrospective Study Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-3-31 Ya-Yin Shen, Jia-Ni Ma, Zi-Yu Ren, Jie Liu, Xin-Yi Zhou, Xue-Rui Xie, Wei Ren
Objective. The effect of physiological dose growth hormone (GH) replacement therapy on bone mineral density (BMD) in adults with growth hormone deficiency (GHD) is not well defined. We aimed to investigate the effects of 18 months of treatment with recombinant human growth hormone (rhGH) at physiological doses on BMD, body composition (BC), and quality of life (QoL). Methods. Sixty-eight patients diagnosed
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Diagnosis and Treatment of Nonfunctioning Pituitary Adenomas with Thyroid Disorders Int. J. Endocrinol. (IF 2.8) Pub Date : 2023-3-27 Xu Wang, Mingchu Li, Xiaohai Liu, Jiantao Liang, Hongchuan Guo, Ge Chen
Objective. Patients with nonfunctioning pituitary adenoma (NFPA) can present with different types of thyroid disorders, which are easily misdiagnosed or missed and can even result in serious clinical consequences. This study was to summarize the different types of thyroid disorders in patients with NFPA with the aim of providing references for the diagnosis and treatment of such patients. Materials